CN109998977A

CN109998977A - A kind of more effect oral cavity nursing agents and preparation method thereof rich in nanometer calcium

Info

Publication number: CN109998977A
Application number: CN201910227894.0A
Authority: CN
Inventors: 唐铁君
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-03-25
Filing date: 2019-03-25
Publication date: 2019-07-12

Abstract

The present invention relates to oral care techniques fields, more particularly to a kind of more effect oral cavity nursing agents and preparation method thereof rich in nanometer calcium, formula is made of 50-70 parts of deionized waters, 5-8 parts of lauryl glucosides, 0.05-0.2 parts of sodium fluorides, 0.1-0.3 parts of protease liquid, 0.05-0.25 parts of nanometer calcium composite powders, 1-4 parts of blown castor oils, 22-40 parts of lubricants, 0.1-0.3 parts of plant extracts, 0.03-0.08 parts of pH adjusting agents, 0.1-0.2 parts of sweeteners and 0.3-1 parts of essence.The present invention is under protease combination nanoscale calcium, several mineral materials, the effectively sodium fluoride of pre- anti-caries and the synergistic effect of multiple natural plant extraction object, have effects that realize clean tooth, breath freshening, nursing oral cavity and the multi-efficiency replenished the calcium well in terms of improving canker sore and swelling and aching of gum.

Description

A kind of more effect oral cavity nursing agents and preparation method thereof rich in nanometer calcium

Technical field

The present invention relates to oral care techniques fields, and in particular to a kind of more effect oral cavity nursing agents rich in nanometer calcium and Preparation method.

Background technique

With the quickening pace of modern life, the increase of operating pressure and various undesirable living habits cause gum red and swollen Or the oral problems such as bleeding, saprodontia, periodontitis, canker sore are more and more, oral care seems particularly important.People are daily For oral care the most commonly used is toothpaste, toothpaste mainly has transparent and opaque two types, wherein opaque toothpaste usually contains The rubbing agent of calcium carbonate, transparent toothpaste then usually contain silica as rubbing agent, and rubbing agent, which plays, wipes dental surface tooth Dirt mitigates the effect of tooth stain, plaque, calculus dentalis, but rubbing agent can cause to damage if being excessively used to tooth and gum Evil.The current most common toothpaste with fluoride contains fluoride, and main function is bactericidal, but Calcium carbonate rubbing agent cannot It is well matched with use with fluoride, and calcium ion content is few in existing toothpaste with fluoride, calcium ion and fluorine element are difficult to inhale Attached calcium ion is lost greatly on tooth surfaces, is unfavorable for the remineralization of tooth, and pre- anti-caries, remove implication at cleaning tooth Effect is poor；Furthermore existing toothpaste is required to be rinsed well using a large amount of mouthwashes, brushes teeth gargle every time after brushing teeth Time it is longer, it is inconvenient to use.

Summary of the invention

It is an object of the invention to aiming at the shortcomings in the prior art, and provide a kind of more effect oral cavities rich in nanometer calcium Care agent and preparation method thereof, the oral cavity nursing agent have clean tooth, breath freshening, nursing oral cavity and the multiple function replenished the calcium Effect.

The purpose of the present invention is achieved through the following technical solutions:

A kind of more effect oral cavity nursing agents rich in nanometer calcium are provided, are made of raw material from the following weight:

Preferably, a kind of more effect oral cavity nursing agents rich in nanometer calcium, are made of raw material from the following weight:

Preferably, the nanometer calcium composite powder is by 30-50 parts of mica ores, 8-15 portions of mother-of-pearls, 10-15 parts of oyster shells It is made with 22-28 parts of oyster shellfishes.

Preferably, the chemical characteristic of the protease liquid is: it is 1.230~1.245 in 27 DEG C of specific gravity, viscosity It is 12.8~14 for 2.875~2.930, pH, boiling point is 102~104 degree.

Preferably, the lubricant is compounded by glycerol and poloxamer188.

Preferably, the plant extract be by propolis extract, chamomile extract and Echinacea extract compounding and At.

Preferably, the sweetener is saccharin sodium, and the pH adjusting agent is citric acid.

Preferably, the essence is at least one of eucalyptus quintessence oil, tea tree ethereal oil and Peppermint essential oil.

The present invention also provides a kind of above-mentioned preparation methods of more effect oral cavity nursing agents rich in nanometer calcium, including following step It is rapid:

Step a, protease liquid is prepared:

A1 plant mixture) is taken, is separately added into lactic acid bacterial liquid 0.02~0.06%, streptococcus lactis by percent by volume Bacterium solution 0.01~0.05%, acetobacter bacterium solution 0.01~0.04% and Kluyveromyces marxianus bacterium solution 0.02~0.06%, After mixing, heap fermentation 15~30 days, the plant mixture after being fermented at 30~50 DEG C；

The plant mixture is Banana Leaf, sweet potato rhizome, jacket, sea sedge, grape branches and leaves, Dracaena palpus dish, emperor Two or more mixtures in beans rhizome and fig rhizome；

A2) by after fermentation plant mixture and deep ocean water according to weight ratio 1:(8~10) Hybrid Heating extract 2~ 3 times, merging filtrate obtains protease liquid；

Step b, nanometer calcium composite powder is prepared:

B1 30-50 parts of mica ore, 8-15 parts of mother-of-pearl, 10-15 parts of oyster shell and oyster shellfish 22-28) are weighed respectively by part Part, each raw material is uniformly mixed, and the dirt on removal raw material surface is cleaned by the way of high-pressure sand blast；

B2) mixed material grinding after cleaning is made to 250-350 μm of particle, be then freeze-dried；

B3) under an inert atmosphere, the particle after freeze-drying is first heated to 500-600 DEG C and carries out thermal decomposition 1.5-2h, It then proceedes to be warming up to 850-1100 DEG C of thermal decomposition 2.5-3h；

B4) mixed material after thermal decomposition is first ground into 30-50 μm of rule particle, be then further ground into partial size For 0.2-0.8nm nano particle to get arrive nanometer calcium composite powder；

Step c, it mixes:

C1 formula ratio) is pressed, lauryl glucoside, blown castor oil and essence are sufficiently dissolved in stirring container, Obtain emulsion；

C2 formula ratio) is pressed, under agitation by deionized water, sodium fluoride, protease liquid and plant extract It is mixed, nanometer calcium composite powder is then added while stirring, lubricant and sweetener are added until completely dissolved, continued Be uniformly mixing to obtain transparent clear solution, be eventually adding pH adjusting agent be adjusted to required pH value to get to described rich in nanometer The oral cavity nursing agent of calcium.

Preferably, in step b1, high-pressure sand blast is the granite using natural sand or crushing, mixing account for natural sand or The water for crushing total amount 8-12%, uses nozzle under the conditions of pressure is 1.0-1.5 gpm for 75-85psi, flow velocity to raw material It is sprayed, injecting time 5-10min；In step b2, the temperature of freeze-drying is -25~-30 DEG C.

Beneficial effects of the present invention:

A kind of preparation method of more effect oral cavity nursing agents rich in nanometer calcium of the invention, formula are gone by 50-70 parts Ionized water, 5-8 part lauryl glucoside, 0.05-0.2 parts of sodium fluorides, 0.1-0.3 parts of protease liquid, 0.05-0.25 parts Nanometer calcium composite powder, 1-4 part blown castor oil, 22-40 parts of lubricants, 0.1-0.3 parts of plant extracts, 0.03-0.08 parts of pH Regulator, 0.1-0.2 part sweetener and 0.3-1 parts of essence are made, wherein protease liquid is using rich in sodium potassium ion Various plants the deep ocean water rich in various trace elements and minerals be added after heap fermentation obtained by extraction , using nanometer calcium composite powder instead of conventional friction agent, it also added various plants extract.Compared with prior art, originally Invention has the advantage that

(1) nanometer calcium composite powder is used in inventive formulation instead of the abrasive of the prior art, the nanometer calcium is compound Powder is processed into using the high shellfish of calcium content and mica ore by special process such as grinding, thermal decompositions, the nanoscale being rich in Calcium can be reacted with various acid compounds, more reach the effect of oral cavity is replenished the calcium on the basis of original friction clear tooth, favorably In the remineralization of enhancing tooth, and nanometer calcium is easy to be adsorbed in dental surface, and good absorption effect compares existing friction Agent, it is only necessary to which considerably less dosage reaches more preferable cleaning and effect of supplemented calcium；

(2) it is added to the protease rich in sodium potassium ion in inventive formulation, is capable of providing high alkalinity environment, And it is easy water completely, the sodium potassium ion being rich in forms sodium potassium pump, can accelerate the chemical reaction of contact material, has catalysis chemical combination special Property, can decompose oral peculiar smell moment and continue to maintain, and penetration is strong, be conducive to the element that compound is reduced into needs and It is absorbed；The sodium fluoride and multiple day of the protease combination nanoscale calcium, several mineral materials, effectively pre- anti-caries The synergistic effect of right plant extract, has effects that well, to realize cleaning in terms of improving canker sore and swelling and aching of gum Tooth, breath freshening, nursing oral cavity and the multi-efficiency replenished the calcium；

(3) in preparation process of the present invention, prepared nanometer calcium composite powder is that original is cleaned by the way of high pressure liquid sandblast Material surface layer can remove rapidly heavy metal and the pollution for being attached to surface layer, and nanoscale is made using thermal decomposition and grinding technics Grain, it is easier to be absorbed, keep the reaction for neutralizing acidic materials more thorough, and avoid secondary pollution；In addition, each component disperses It is uniformly mixed, preparation process is simple, easily controllable, it can be achieved that large-scale production；

(4) oral cavity nursing agent of the invention, the transparent liquid of appearance are extruded in toothbrush as the careful bubble of mousse by pump Foam, deutostoma of normally brushing teeth is containing the effect of reaching removal implication of gargling, and similar dry-cleaning is not required to a large amount of water and gargles when use, very It is convenient.

Specific embodiment

The invention will be further described with the following Examples.

Embodiment 1:

A kind of preparation method of more effect oral cavity nursing agents rich in nanometer calcium of the present embodiment, include the following steps (with Lower each component is in parts by weight):

Step a, protease liquid is prepared:

A1) weighing 80 parts of Banana Leaf, 80 parts of jacket, 60 parts of sweet potato rhizome and 50 parts of Dracaena respectively must dish The plant mixture of composition is separately added into lactic acid bacterial liquid 0.04%, the lactic acid chain that concentration is 180cfu/ml by percent by volume Coccus bacterium solution 0.03%, acetobacter bacterium solution 0.03% and Kluyveromyces marxianus bacterium solution 0.04%, after mixing, at 42 DEG C Heap fermentation 20 days, the plant mixture after being fermented；

A2) by after fermentation plant mixture and deep ocean water according to weight ratio 1:9 Hybrid Heating extract 2 times, merge Filtrate obtains protease liquid.

The chemical characteristic of the protease liquid is: being 1.235 in 27 DEG C of specific gravity, viscosity 2.883, pH is 13.1, boiling point is 103 degree, in which: sodium ions content 42000mg/kg, the content of potassium ion are 13750mg/kg, calcium ion Content is 462mg/kg, iron ion content 86mg/kg, magnesium ion content 120mg/kg.

Step b, nanometer calcium composite powder is prepared:

B1 38 parts of mica ore, 10 parts of mother-of-pearl, 12 parts of oyster shell and 26 parts of oyster shellfish) are weighed respectively by part, by each raw material It is uniformly mixed, and cleans the dirt on removal raw material surface by the way of high-pressure sand blast；High-pressure sand blast be using natural sand or The granite of crushing, mixing account for natural sand or crush the water of total amount 11%, use the nozzle to be for 75-psi, flow velocity in pressure Raw material is sprayed under the conditions of 1.0 gpms, injecting time 10min；

B2) mixed material grinding after cleaning is made to 250 μm of particle, be then freeze-dried at -25 DEG C；

B3) under an inert atmosphere, the particle after freeze-drying is first heated to 500 DEG C and carries out thermal decomposition 2h, then proceeded to It is warming up to 850 DEG C of thermal decomposition 3h；

B4) mixed material after thermal decomposition is first ground into 30 μm of rule particle, being then further ground into partial size is The nano particle of 0.2nm to get arrive nanometer calcium composite powder.

Step c, it mixes:

C1) 5 parts of lauryl glucosides, 1 part of blown castor oil, 0.1 part of eucalyptus quintessence oil and 0.2 part of tea tree ethereal oil are being stirred It mixes in container and is sufficiently dissolved, obtain emulsion；

C2) by 50 parts of deionized waters, 0.05 part of sodium fluoride, 0.2 part of protease liquid, 0.02 part of propolis extract, 0.06 part of chamomile extract and 0.02 part of Echinacea extract, are mixed under agitation, then. while stirring 0.05 part of nanometer calcium composite powder is added, 10 parts of glycerol, 12 parts of poloxamer188s and 0.1 part of saccharin sodium are added until completely dissolved, Continue to be uniformly mixing to obtain transparent clear solution, is eventually adding 0.03 part of citric acid and is adjusted to required pH value to get to rich in receiving The oral cavity nursing agent of rice calcium.

Embodiment 2:

Step a, protease liquid is prepared

A1 the plant for) weighing 80 parts of Banana Leaf, 60 parts of sweet potato rhizome and 50 parts of emperor's beans rhizome composition respectively is mixed Object is closed, being separately added into concentration by percent by volume is the lactic acid bacterial liquid 0.03% of 150cfu/ml, streptococcus lactis bacterium solution 0.01%, acetobacter bacterium solution 0.02% and Kluyveromyces marxianus bacterium solution 0.02%, after mixing, the heap fermentation at 37 DEG C 25 days, the plant mixture after being fermented；

A2) by after fermentation plant mixture and deep ocean water according to weight ratio 1:8 Hybrid Heating extract 2 times, merge Filtrate obtains protease liquid.

Chemical characteristic in the protease liquid is: being 1.241 in 27 DEG C of specific gravity, viscosity 2.914, pH is 13.5, boiling point is 103 degree, in which: sodium ions content 37000mg/kg, the content of potassium ion are that 21360mg/kg calcium ion contains Amount is 520mg/kg, iron ion content 92mg/kg, magnesium ion content 131mg/kg.

Step b, nanometer calcium composite powder is prepared

B1 30 parts of mica ore, 8 parts of mother-of-pearl, 15 parts of oyster shell and 22 parts of oyster shellfish) are weighed respectively by part, each raw material is mixed It closes uniformly, and cleans the dirt on removal raw material surface by the way of high-pressure sand blast；High-pressure sand blast is using natural sand or powder Broken granite, mixing account for natural sand or crush total amount 10% water, use nozzle pressure for 85psi, flow velocity be 1.5 plus Logical sequence/point under the conditions of raw material is sprayed, injecting time 5min；

B2) mixed material grinding after cleaning is made to 300 μm of particle, be then freeze-dried at -30 DEG C；

B3) under an inert atmosphere, the particle after freeze-drying is first heated to 530 DEG C and carries out thermal decomposition 1.8h, then after It is continuous to be warming up to 950 DEG C of thermal decomposition 2.8h；

B4) mixed material after thermal decomposition is first ground into 40 μm of rule particle, being then further ground into partial size is The nano particle of 0.5nm to get arrive nanometer calcium composite powder；

Step c, it mixes:

C1) by 8 parts of lauryl glucosides, 4 parts of blown castor oils, 0.2 part of eucalyptus quintessence oil, 0.3 part of tea tree ethereal oil and 0.5 Part Peppermint essential oil is sufficiently dissolved in stirring container, obtains emulsion；

C2) by 70 parts of deionized waters, 0.2 part of sodium fluoride, 0.3 part of protease liquid, 0.1 part of propolis extract, 0.1 Part chamomile extract and 0.1 part of Echinacea extract are mixed under agitation, are then added while stirring 20 parts of glycerol, 20 parts of poloxamer188s and 0.2 part of saccharin sodium is added in 0.25 part of nanometer calcium composite powder until completely dissolved, continues It is uniformly mixing to obtain transparent clear solution, 0.08 part of citric acid is eventually adding and is adjusted to required pH value to get to rich in nanometer calcium Oral cavity nursing agent.

Embodiment 3:

Step a, protease liquid is prepared

A1 80 parts of Banana Leafs, 80 parts of jackets, 60 parts of sweet potato rhizomes, 30 portions of sea sedges, 50 parts of grape branches) are weighed respectively The plant mixture of leaf, 60 parts of emperor's beans rhizomes and 50 parts of Dracaena palpus dish compositions, being separately added into concentration by percent by volume is Lactic acid bacterial liquid 0.06%, streptococcus lactis bacterium solution 0.04%, acetobacter bacterium solution 0.01% and the Marx gram of 120cfu/ml Tie up yeast liquid 0.03%, after mixing, heap fermentation 30 days, the plant mixture after being fermented at 30 DEG C in Shandong；

The plant mixture includes Banana Leaf, sweet potato rhizome, jacket, sea sedge, grape branches and leaves, Dracaena palpus dish, emperor Two or more mixtures in Supreme Being's beans rhizome and fig rhizome；

A2) by after fermentation plant mixture and deep ocean water according to weight ratio 1:10 Hybrid Heating extract 3 times, merge Filtrate obtains protease liquid.

Chemical characteristic in the protease liquid is: being 1.230 in 27 DEG C of specific gravity, viscosity 2.876, pH is 12.8, boiling point is 102 degree, in which: sodium ions content 53500mg/kg, the content of potassium ion are that 31300mg/kg calcium ion contains Amount is 550mg/kg, iron ion content 102mg/kg, magnesium ion content 139mg/kg.

Step b, nanometer calcium composite powder is prepared

B1 45 parts of mica ore, 15 parts of mother-of-pearl, 13 parts of oyster shell and 24 parts of oyster shellfish) are weighed respectively by part, by each raw material It is uniformly mixed, and cleans the dirt on removal raw material surface by the way of high-pressure sand blast；High-pressure sand blast be using natural sand or The granite of crushing, mixing account for natural sand or crush the water of total amount 8%, use nozzle in pressure for 78psi, flow velocity 1.2 Raw material is sprayed under the conditions of gpm, injecting time 8min；

B2) mixed material grinding after cleaning is made to 350 μm of particle, be then freeze-dried at -28 DEG C；

B3) under an inert atmosphere, the particle after freeze-drying is first heated to 600 DEG C and carries out thermal decomposition 1.5h, then after It is continuous to be warming up to 1100 DEG C of thermal decomposition 2.5h；

B4) mixed material after thermal decomposition is first ground into 50 μm of rule particle, being then further ground into partial size is The nano particle of 0.8nm to get arrive nanometer calcium composite powder；

Step c, it mixes:

C1) 7 parts of lauryl glucosides, 3 parts of blown castor oils and 0.5 part of tea tree ethereal oil and 0.3 part of Peppermint essential oil are being stirred It mixes in container and is sufficiently dissolved, obtain emulsion；

C2) by 65 parts of deionized waters, 0.15 part of sodium fluoride, 0.1 part of protease liquid and 0.06 part of propolis extract, 0.05 part of chamomile extract and 0.09 part of Echinacea extract are mixed under agitation, are then added while stirring Enter 0.12 part of nanometer calcium composite powder, 12 parts of glycerol, 23 parts of poloxamer188s and 0.13 part of saccharin sodium be added until completely dissolved, Continue to be uniformly mixing to obtain transparent clear solution, is eventually adding 0.05 part of citric acid and is adjusted to required pH value to get to rich in receiving The oral cavity nursing agent of rice calcium.

Embodiment 4:

Step a, protease liquid is prepared

A1 the plant of 80 parts of Banana Leafs, 40 portions of sea sedges, 50 parts of grape branches and leaves and 60 parts of emperor's beans rhizomes composition) is weighed respectively Mixture, being separately added into concentration by percent by volume is the lactic acid bacterial liquid 0.02% of 200cfu/ml, streptococcus lactis bacterium solution 0.05%, acetobacter bacterium solution 0.02% and Kluyveromyces marxianus bacterium solution 0.06%, after mixing, the heap fermentation at 50 DEG C 15 days, the plant mixture after being fermented；

A2) by after fermentation plant mixture and deep ocean water according to weight ratio 1:8.5 Hybrid Heating extract 3 times, close And filtrate, obtain protease liquid.

Chemical characteristic in the protease liquid is: being 1.245 in 27 DEG C of specific gravity, viscosity 2.930, pH is 14, boiling point is 104 degree, in which: sodium ions content 66000mg/kg, the content of potassium ion are 26180mg/kg calcium ion content For 430mg/kg, iron ion content 108mg/kg, magnesium ion content 150mg/kg.

Step b, nanometer calcium composite powder is prepared

B1 50 parts of mica ore, 12 parts of mother-of-pearl, 10 parts of oyster shell and 28 parts of oyster shellfish) are weighed respectively by part, by each raw material It is uniformly mixed, and cleans the dirt on removal raw material surface by the way of high-pressure sand blast；High-pressure sand blast be using natural sand or The granite of crushing, mixing account for natural sand or crush the water of total amount 12%, use nozzle in pressure for 82psi, flow velocity 1.3 Raw material is sprayed under the conditions of gpm, injecting time 6min；

B2) mixed material grinding after cleaning is made to 320 μm of particle, be then freeze-dried at -26 DEG C；

B3) under an inert atmosphere, the particle after freeze-drying is first heated to 580 DEG C and carries out thermal decomposition 1.6h, then after It is continuous to be warming up to 1000 DEG C of thermal decomposition 2.6h；

B4) mixed material after thermal decomposition is first ground into 45 μm of rule particle, being then further ground into partial size is The nano particle of 0.5nm to get arrive nanometer calcium composite powder；

Step c, it mixes:

C1) by 6 parts of lauryl glucosides, 2 parts of blown castor oils and 0.1 part of eucalyptus quintessence oil, 0.2 part of tea tree ethereal oil and 0.2 part of Peppermint essential oil is sufficiently dissolved in stirring container, obtains emulsion；

C2) by 58 parts of deionized waters, 0.1 part of sodium fluoride, 0.25 part of protease liquid and 0.16 part of plant extract 0.03 part of propolis extract, 0.07 part of chamomile extract and 0.06 part of Echinacea extract are mixed under agitation, Then 0.2 part of nanometer calcium composite powder is added while stirring, 10 parts of glycerol, 18 parts of poloxamers are added until completely dissolved 407 and 0.17 parts of saccharin sodiums continue to be uniformly mixing to obtain transparent clear solution, are eventually adding needed for 0.06 part of citric acid is adjusted to PH value to get arrive the oral cavity nursing agent rich in nanometer calcium.

The present embodiment is merely illustrative of the technical solution of the present invention, rather than limiting the scope of the invention, although ginseng The present invention is explained in detail according to preferred embodiment, those skilled in the art should understand that, it can be to the present invention Technical solution be modified or replaced equivalently, without departing from the spirit and scope of technical solution of the present invention.

Claims

1. a kind of more effect oral cavity nursing agents rich in nanometer calcium, it is characterised in that: be made of raw material from the following weight:

2. a kind of more effect oral cavity nursing agents rich in nanometer calcium according to claim 1, it is characterised in that: by following heavy The raw material of amount part is made:

3. a kind of more effect oral cavity nursing agents rich in nanometer calcium according to claim 1 or 2, it is characterised in that: described Nanometer calcium composite powder is made of 30-50 parts of mica ores, 8-15 portions of mother-of-pearls, 10-15 parts of oyster shells and 22-28 parts of oyster shellfishes.

4. a kind of more effect oral cavity nursing agents rich in nanometer calcium according to claim 1 or 2, it is characterised in that: described The chemical characteristic of protease liquid is: being 1.230~1.245 in 27 DEG C of specific gravity, viscosity is that 2.875~2.930, pH is 12.8~14, boiling point is 102~104 degree.

5. a kind of more effect oral cavity nursing agents rich in nanometer calcium according to claim 1 or 2, it is characterised in that: described Lubricant is compounded by glycerol and poloxamer188.

6. a kind of more effect oral cavity nursing agents rich in nanometer calcium according to claim 1 or 2, it is characterised in that: described Plant extract is compounded by propolis extract, chamomile extract and Echinacea extract.

7. a kind of more effect oral cavity nursing agents rich in nanometer calcium according to claim 1 or 2, it is characterised in that: described Sweetener is saccharin sodium, and the pH adjusting agent is citric acid.

8. a kind of more effect oral cavity nursing agents rich in nanometer calcium according to claim 1 or 2, it is characterised in that: described Essence is at least one of eucalyptus quintessence oil, tea tree ethereal oil and Peppermint essential oil.

9. a kind of preparation method of more effect oral cavity nursing agents rich in nanometer calcium as described in claim 1 to 8 any one, It is characterized by comprising following steps:

Step a, protease liquid is prepared:

A1 plant mixture) is taken, is separately added into lactic acid bacterial liquid 0.02~0.06%, streptococcus lactis bacterium solution by percent by volume 0.01~0.05%, acetobacter bacterium solution 0.01~0.04% and Kluyveromyces marxianus bacterium solution 0.02~0.06% mix Afterwards, heap fermentation 15~30 days at 30~50 DEG C, the plant mixture after being fermented；

The plant mixture is Banana Leaf, sweet potato rhizome, jacket, sea sedge, grape branches and leaves, Dracaena palpus dish, emperor's beans root Two or more mixtures in stem and fig rhizome；

A2) by after fermentation plant mixture and deep ocean water according to weight ratio 1:(8~10) Hybrid Heating extract 2~3 times, Merging filtrate obtains protease liquid；

Step b, nanometer calcium composite powder is prepared:

B1 30-50 parts of mica ore, 8-15 parts of mother-of-pearl, 10-15 parts of oyster shell and 22-28 parts of oyster shellfish) are weighed respectively by part, it will Each raw material is uniformly mixed, and the dirt on removal raw material surface is cleaned by the way of high-pressure sand blast；

B3) under an inert atmosphere, the particle after freeze-drying is first heated to 500-600 DEG C and carries out thermal decomposition 1.5-2h, then It is continuously heating to 850-1100 DEG C of thermal decomposition 2.5-3h；

B4) mixed material after thermal decomposition is first ground into 30-50 μm of rule particle, being then further ground into partial size is The nano particle of 0.2-0.8nm to get arrive nanometer calcium composite powder；

Step c, it mixes:

C1 formula ratio) is pressed, lauryl glucoside, blown castor oil and essence are sufficiently dissolved in stirring container, obtained Emulsion；

C2 formula ratio) is pressed, deionized water, sodium fluoride, protease liquid and plant extract are carried out under agitation Mixing, is then added nanometer calcium composite powder while stirring, and lubricant and sweetener are added until completely dissolved, continues to stir Uniformly obtain transparent clear solution, be eventually adding pH adjusting agent be adjusted to required pH value to get to described rich in nanometer calcium Oral cavity nursing agent.

10. a kind of preparation method of more effect oral cavity nursing agents rich in nanometer calcium according to claim 9, feature exist In: in step b1, high-pressure sand blast is the granite using natural sand or crushing, and mixing accounts for natural sand or crushes total amount 8- 12% water uses nozzle to spray under the conditions of pressure is 1.0-1.5 gpm for 75-85psi, flow velocity raw material, spray Penetrating the time is 5-10min；In step b2, the temperature of freeze-drying is -25~-30 DEG C.