CN109985208B - 一种消痞膏贴的中药组合物 - Google Patents

一种消痞膏贴的中药组合物 Download PDF

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CN109985208B
CN109985208B CN201910241957.8A CN201910241957A CN109985208B CN 109985208 B CN109985208 B CN 109985208B CN 201910241957 A CN201910241957 A CN 201910241957A CN 109985208 B CN109985208 B CN 109985208B
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付艳霞
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Fu Bichi
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Abstract

本发明涉及一种具有消痞功效的中药膏贴,由以下重量份的原料制备而成:大戟1~2份、肉桂1~2份、草河车1~2份、蓬莪术1~2份、白芥子1~2份、半夏1~2份、胆南星1~2份、生牡蛎1~2份、土元1~2份、僵蚕1~2份、橘核1~2份、柴胡0.25‑0.5份、麻黄0.25~0.5份、郁金1‑2份、木香1~2份、川芎1~2份、芒硝1‑2份、天花粉1~2份、玄参1~2份、甘遂0.25~0.5份、夏枯草1~2份、全蝎0.25~0.5份、川乌0.25~0.5份、紫石英1~2份、茯神1~2份、天冬1~2份、南沙参1‑2份、黄丹0.5~1份、麻油1~2份,适用于结节、乳腺增生、颈及锁骨下淋巴结肿大等。

Description

一种消痞膏贴的中药组合物
技术领域
近数十年来,药物经皮经络渗透技术领先世界外界法潮流。例如从最早避孕药贴臂部、胰岛素泵调量调时、妇科更年期阴道给药等。至2019年01月,帕金森症手腕贴已进入国内十市场。痞,为中医病症名。痞之痞结,为气滞痰瘀结,经久不愈之义。其治疗在于手术、放疗、化疗、靶向、中药内服等方法,疗效有一定限制,只能缓解部分症状,副作用明显,胃肠道反应重,肝肾多有损伤,或价格昂贵。人们很难找到完美方案。中西医结合中的药外治制剂的独特疗效,逐渐走入视野。
本发明的目的及达到的技术效果:提出一种新的中药组合物综合处方,安全无毒副作用,价格实惠,临床疗效可靠。
背景技术
北宋窦材《扁鹊心书》、清代吴师机《理瀹骈文》外用膏貼剂型的理论和实践,应视为开拓先河之神笔。万春消痞贴的上市,是在国家大健康战略里中医中药难得的发展机遇下,在民间发掘足贴腰贴背贴泥沙莫辨激流中,以学院派人为主导,承古创新,励精图治的外用膏贴剂,在迄今为止的6、7十种中成药中独树一帜。之前组方都分类复杂,局限内服。外用仅是药粉,布局狭小。
例如分类号A61K36/9066;A61P15/14;A61K35/646;A61K35/583;A61K35/64;A61K35/62;A61K35/648公开了一种治疗乳癖的中药组合物,由以下质量份组成:蜈蚣 25~30、全蝎10~15、炒土元18~22、炒天龙18~22、炒水蛭18~22、象贝13~18、蒸晒三棱13~18、蒸晒莪术8~12、蒸晒夏枯球18~22。本发明组方软坚散结,活血消痛。用于痰结所致的乳癖、乳痛、乳房结节、乳房结块,乳腺增生。对子宫肌瘤初期,输卵管囊肿有一定预防和疗效,对乳腺癌、子宫癌有一定防治作用。
另有分类号为A61K36/904;A61P35/00;A61K35/648;公开了一种治疗肺癌的中药组合物,由以下重量配比的原料药组成:南沙参10-18份、北沙参10-18份、天冬10-20 份、麦冬10-20份、黄芪15-60份、白英15-30份、百合10-30份、白茅根 30-50份、白花蛇舌草15-30份、鱼腥草15-30份、铁树叶15-30份、生薏仁 15-30份、橘红10-20份、陈皮10-15份、焦白术10-30份、半夏10-15份、石见穿10-30份、紫草10-30份、百部10-30份、徐长卿10-20份、三七10-30份、全蝎3-10份、干蜈蚣5-25份;本发明疗效显著,药性平和,作用可靠,未出现毒副作用,有效控制病情继续恶化。
另有分类号A61K36/9066;A61K35/618;A61P15/14;A61P35公开了一种治疗乳腺癌的中药组合物,属中药领域。该中药组合物由党参20-60份、红花10-40份、没药10-30 份、川牛膝10-30份、板蓝根5-15份、茵陈蒿10-30份、月见草10-30份、瓦楞子5- 15份、车前草5-15份、枳壳5-20份、川贝10-30份、郁金10-30份、王不留行20-40 份、仙灵脾10-30份、青钱柳叶10-30份制成。本发明的中药组合物中各药协同作用,治疗乳腺癌的效果显著,总有效率可达88%,治愈率可达76%,且治愈后不易复发。
发明内容
药品组成
一种消痞膏貼的中药组合物,有以下重量份的组分组成:必要:大戟1-2份 肉桂1-2份 草河车1-2份 蓬莪术1-2份 白芥子1-2份 胆南星1-2份 半夏1-2份 生牡蛎1-2份 僵蚕1-2份 土元1-2份 天花粉1-2份 橘核1-2份 柴胡0.25-0.5份 麻黄0.25-0.5份 郁金1-2份 木香1-2份 川芎1-2份 芒硝1-2份 玄参1-2份。非必要:南沙参甘遂0.25-0.5份 夏枯草1-2份、全蝎0.25-0.5份 川乌0.25-0.5份 天冬1-2份 紫石英1-2份 茯神1-2份 南沙参1-2份 黄丹0.5-1份 麻油1-2份。
制备方法:
打细粉,过筛,炼油,炸药,下丹,下粉,泡洗,晾晒,压片,切片,贴片,装袋,打码,装盒,装箱,打包,发货。
用途:
适用于结节、乳腺增生、乳腺纤维腺瘤、甲状腺肿、颈及锁骨淋巴结肿大、各种肿瘤见痞症小于3厘米者。具有治疗及辅助治疗作用。
原理:方中大戟苦寒峻猛,泻水逐饮,消肿散结,肉桂补元阳、暖脾胃、除积冷、通血脉,草河车清热解毒、消肿止痛,蓬莪术行气破血,消积止痛,4药共为君药;辅以白芥子温化寒痰、通络止痛,半夏燥湿化痰、消痞满、降逆气,胆南星清热燥湿、散结消肿,牡蛎化痰软坚4药共为臣药;土元、僵蚕、橘核、芒硝逐瘀软坚、消肿收敛,既有前两味脂溶性通透血脉,又因后两味协助攻邪,共为佐,辅助君药发挥治疗作用;妙在麻黄、柴胡辛温发散,透皮吸收,促进组织体液代谢,川芎、郁金行气解郁止痛,天花粉、玄参润燥养阴缓急为使药。麻油、黄丹为引经之品。
剂型:
膏贴
用法:
外用,每次1贴,每日1次,每次6-12小时,用时揭下盖衬帖敷患处,或灸1至2小时。
讨论与结论:
中医学之痞,早见于《伤寒论》五个“泻心汤”之热证、寒热错杂证、水证、痰证、食证,主要归肝、脾、胃、心经,是因气滞而痰食水瘀结于局部形成。北宋窦材《扁鹊心书》与明朝陈实功的《外科正宗》记载的和荣散坚丸、阿魏化痞膏对外治法已有探索,清代吴师机《理瀹骈文》对膏贴剂型进行了大量的临床理论和实践,悬壶济世,恩泽至今。根据临床证侯,痞积、肿瘤形成病因复杂多变,多涉五脏六腑,故在化痰通络、散结消肿的基础上,辅以扶正、解毒、凉血、养阴、行气、止痛、安神之品组方,较恰适病机,当为妥善虑选。
临床试验:
1.一般资料:本发明人甄选对100例病例进行临床观察,其中男23例,女77例;年龄最小16岁,最大82岁;乳腺增生34例,乳腺结节22例,乳腺腺瘤5例,甲状腺结节7例,颈淋巴结肿大14例,锁骨下淋巴结肿大7例,乳腺癌术后锁骨下淋巴结转移 4例,乳腺癌术后放疗后肋骨转移3例,乳腺癌胸壁转移1例,霍奇金氏淋巴瘤腹股沟转移2例,肾母细胞瘤术后放疗后骨转移1例。
2.治疗方法:每人每天贴敷万春消痞贴,临睡前贴,每次8-12小时。1日1次,2周为一疗程。
3.疗效评定标准:
治愈:临床症状完全消失,恢复正常生活。
有效:全部或主要症状明显消除,只部分恢复正常生活。
无效:症状体征无明显变化。
4.治疗结果:如表所示
Figure BSA0000181057100000031
5.典型病例:
5.1陈某,女,43岁,月经错后不规则加左侧乳腺增生伴小结节3个,分别在12点位1个和3点位2个。经内服中药加贴敷万春消痞贴30贴,2个月小结节完全消失。
5.2谢某,女,56岁,2018年6月17日就诊。乳腺癌术后1年,经规范放疗6次,骨扫描示和X线DR数字显影双侧肋骨转移。经内服中药调解免疫加间歇贴敷万春消痞45贴3 个月,骨扫描肋骨转移显示完全消失。

Claims (1)

1.一种具有消痞功效的中药膏贴,其特征在于:由以下重量份的原料制备而成:大戟1~2份、肉桂1~2份、草河车1~2份、蓬莪术1~2份、白芥子1~2份、半夏1~2份、胆南星1~2份、生牡蛎1~2份、土元1~2份、僵蚕1~2份、橘核1~2份、柴胡0.25-0.5份、麻黄0.25~0.5份、郁金1-2份、木香1~2份、川芎1~2份、芒硝1-2份、天花粉1~2份、玄参1~2份、甘遂0.25~0.5份、夏枯草1~2份、全蝎0.25~0.5份、川乌0.25~0.5份、紫石英1~2份、茯神1~2份、天冬1~2份、南沙参1-2份、黄丹0.5~1份、麻油1~2份。
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CN102240382A (zh) * 2011-07-12 2011-11-16 张俊波 一种治疗乳腺增生的药物
CN105943770A (zh) * 2016-06-22 2016-09-21 叶龙海 一种治疗乳腺癌、乳腺增生的中药组合物及其制备方法

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CN102240382A (zh) * 2011-07-12 2011-11-16 张俊波 一种治疗乳腺增生的药物
CN105943770A (zh) * 2016-06-22 2016-09-21 叶龙海 一种治疗乳腺癌、乳腺增生的中药组合物及其制备方法

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