CN109985136A - 治疗股骨头坏死的中药组合物 - Google Patents
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Abstract
本发明利用狗脊、补骨脂、骨碎补、续断、三七、丹参、防己、香薷、泽泻、茯苓、郁李仁等原料药并通过它们之间各成分的不同配比,形成治疗股骨头坏死的中药组合物,该组合物具有活血化瘀、祛风除湿、补肾强骨的效果并能够进一步改善人体骨骼的胶原结构,从而起到很好的促进骨愈合及软骨细胞再生的效果,针对各种原因造成的股骨头坏死进行治疗,效果显著且无任何副作用,对股骨头坏死患者治愈率有明显的提升。
Description
技术领域
本发明涉及一种用于治疗股骨头坏死的中药组合物。
背景技术
股骨头坏死是一种常见的免疫性疾病,其属于因多种原因导致的股骨头局部血运不良,从而引起骨细胞进一步缺血和坏死而造成骨小梁断裂、股骨头塌陷等症的一种病变,并导致关节畸形和功能丧失,给患者日常生活带来很多不便和极大的困扰。在现有技术中,针对股骨头坏死疾病,西医主要采取西药抗菌消炎并配合激素类物质对骨关节进行刺激,采用该疗法,虽然可提高股骨头血流量,改善骨组织结构,并起到到消炎为止痛的效果,但不能阻止股骨头病变的过程,且长期使用激素类物质对肝肾会造成很大的损伤,所以,很难达到理想的治疗效果;而中医治疗股骨头坏死通常采用淫羊藿、狗脊、补骨脂当归、丹参等中药制成汤剂和药膏内服外敷进行治疗,虽然采取此方式可以缓解股骨头坏死病症,但产生股骨头坏死的原因绝大部分是免疫功能下降和血液粘稠度下降以及受骨组织病变影响造成骨内微细血管阻塞,骨质合成减少,钙吸收障碍,骨质疏松等症状所以,要想达到理想的治疗效果应该从提高骨组织自身功能和人体免疫力方面下手,并使关节能够免受风寒侵袭,此时,采用能够清热解毒、活血化瘀、消肿止痛的中药进行治疗是关键。
为此,中国专利104161823A号公开的名称为“一种治疗股骨头无菌性坏死的中药”提出一种方案。该中药内服中药颗粒是由淫羊藿,补骨脂,续断,鹿衔草,黄芪,当归,丹参,延胡索,鹿角霜,牛膝,透骨草,伸筋草,羌活,独活,三七,蜈蚣,威灵仙制成;外敷药物是由血竭,自然铜,红花,狗脊,制马钱子,烫骨碎补,黄连,草乌,醋乳香,醋没药,猪脂所制成,虽然该专利所提出的中药具有添精益髓,强壮筋骨,活血化淤,通经活络,消肿止痛,养血生骨的作用,但其仅仅无菌性股骨头坏死这类病症进行治疗,实施范围窄,且没有从提高骨组织自身功能和人体免疫力等方面着手治疗,所以,其治疗效果还有待于进一步探讨。
发明内容
本发明的目的是利用原料药并通过它们之间各成分的不同配比,产生祛风除湿、通络止痛的效果形成一种治疗股骨头坏死的中药组合物,该组合物采用内服外敷的方式从提高骨组织自身功能和人体免疫力方面着手,对股骨头坏死进行治疗效果明显且无任何副作用。
本发明所提出的治疗股骨头坏死的中药组合物包括以下质量百分比的原料药:狗脊20-40%,补骨脂10-30%,骨碎补10-30%,续断5-20%,三七5-15%,丹参3-12%,防己2-10%,香薷2-8%,泽泻1-5%,茯苓1-5%,郁李仁1-5%。其中狗脊具有祛风除湿,强腰健肾的功效,可祛风湿、健腰脚、利关节,是治疗风湿痹痛、腰膝酸软的重要药材;补骨脂补肾壮阳、补脾健胃,含有补骨脂素成分,可以增强人体自身免疫力,预防多种疾病的发生;骨碎补有补肾强骨、续伤止痛之功效,并具有抗细胞退行性变的作用,其能够增加体内钙与磷的含量,有助于消除胀痛和体内的积液,针对骨组织变形以及骨内微细血管阻塞,骨质合成减少,钙吸收障碍,骨质疏松等症进行治疗最为适合;续断有补肝肾、强筋骨、续折伤、止崩漏的功效,其富含的总皂苷及其它成分,能促进身体内抗体多糖生成,加快身体内血液循环及免疫细胞再生速度,并增强体内抗体活性,进一步提高身体免疫力并增强体内抗体活性,从而改善人体骨骼的胶原结构,起到很好的促进骨愈合及软骨细胞再生的效果,在股骨头坏死方面有奇效;三七散瘀止血、消肿定痛,有消炎止痛、强身健体之功效;丹参具有活血祛瘀、通经止痛、凉血消痈之功效,其能扩张外周血管,进一步增加心肌血流量并刺激中枢神经,有效地促进血液循环与组织修复再生,同时,还可以有效调节机体新陈代谢并增强细胞营养,从而显著增强骨组织的特异性功能;防己具有祛风止痛、利水消肿的功效,专治由风寒所引起的外感表证、风湿痹痛、脾虚湿盛和骨节酸痛等症;香薷具有发汗解表、化湿和中、利水消肿之功效,其所含有的江香薷及青香薷挥发成分能促进肾脏血管扩张充血并进一步刺激中枢神经,针对大肠杆菌、金黄色葡萄球菌、脑膜炎双球菌、伤寒杆菌等多种病菌有很强的抑制作用,并具有调节血液循环和免疫功能及控制机体平衡的作用,还可增强对骨组织的刺激调节和机体对非特异性刺激的防御功能;泽泻具有利水去囊肿水肿的性能和抑制免疫及抗炎之功效,同时,还可以迅速降低人体肝脏内脂肪量,对人体血液之中的脂肪及甘油三酯等含量也有很好的控制及调节作用,从而进一步促进消化并改善病患自身体质,针对骨损伤、骨组织病变及钙磷代谢失常等脑瘫及脑积水患者股骨头坏死病症进行治疗作为适合;茯苓具有利水渗湿、益脾和胃、宁心安神之功效,其能够增强机体免疫能力,从而进一步促进细胞生长并提高生物活性;郁李仁富含多种有机酸、纤维素及油酸等成分,具有润燥滑肠,下气行滞,利水消肿之功效,可泄肝胆实火、除下焦湿热,且除湿止痛效果显著,配合香薷一起使用效果更佳;
为了更好地提升治疗效果,还可以在组合物中添加金果榄,熟地黄,当归,党参,黄芪,大蓟,桔梗,鱼腥草,牛膝。金果揽是一种祛苦寒和清热解毒及消炎散结的良药,其抗菌消炎效果明显且迅速止痛,有很好的刺激机体促肾上腺皮质分泌作用,可有效促进血液循环与组织修复再生,配合三七一起使用效果更佳;熟地黄是养血滋阴的良药,具有养肝益肾、补血滋阴之功效,其富含的熟地黄多糖成分能参与并改善机体新陈代谢,提升体内免疫细胞增殖速度,从而进一步增强自身免疫力及抵抗力;当归属于一种常见的补血活血的中药药材,可解除痉挛从而消肿止痛,对风寒湿痹、项强筋急、骨节酸痛等病症最为适合;党参补中益气、健脾润肺,其富含多种糖类、酚类、甾醇、挥发油、黄芩素葡萄糖甙、皂甙及微量生物碱等成分,在增强免疫力、扩张血管、改善微循环及增强造血功能等方面作用明显;黄芪不仅能提高免疫功能,调节血压循环系统,还能够延缓细胞衰老;大蓟可凉血止血,祛瘀消肿,同时其还含有多种天然抗炎成分,针对体内的多种炎症和病毒进行治疗效果显著;桔梗有抗炎和免疫增强作用及镇咳平喘之功效,抗病菌效果突出,且能针对骨细胞产生局部刺激并具有很好的溶血功能;鱼腥草中含有大量对身体有益的营养元素,除了一般的蛋白质、氨基酸、维生素、脂肪、多糖之外,还有黄酮类、有机酸和大量的微量元素,具有清热解毒及抗菌消炎作用,其可促进组织细胞再生,从而进一步增强人体免疫力;牛膝通经活血,强筋骨、补肝肾,特别适合腰膝疼痛、筋骨无力、下肢萎软等情况;
添加后各原料药的质量百分比为:狗脊20-40%,补骨脂10-30%,骨碎补10-30%,续断5-20%,三七5-15%,丹参3-12%,防己2-10%,香薷2-8%,泽泻1-5%,茯苓1-5%,郁李仁1-5%,金果榄5-15%,熟地黄5-15%,当归3-15%,党参3-10%,黄芪2-10%,大蓟2-8%,桔梗1-5%,鱼腥草1-5%,牛膝1-5%。
另外,还可以添加龟甲,柴胡,透骨草,川穹,升麻,甘草,路路通。龟甲具有滋阴潜阳、益肾强骨、退热除蒸、养血补心之功效,其提取物能增强毛细血管抵抗力,并能促进骨髓的造血功能,进一步提高人体免疫功能;柴胡有和解表里、疏肝升阳之功效,主治肝郁气滞、胸肋胀痛,其所含有的柴胡多糖成分可增强细胞的吞噬功能,利于消除体内病毒且解热镇痛效果突出;透骨草活血止痛、解毒化疹,是民间一种镇痛、抗风湿、治跌打损伤的良药;川芎具有下行,活血化瘀和通络止痛的功效,可祛风除湿、通达气血,进一步刺激和调节人类免疫系统,从而对细胞免疫产生抑制及对抗作用;升麻消肿拔毒、镇静解痉、祛风活血,有散瘀、止痛、镇静之功效,对风湿关节痛、跌打瘀痛和风寒效果明显;甘草具有润肿解毒的功效,可补脾益气、缓急止痛、抗菌消炎,能显著增强治疗挛急疼痛的疗效并有效刺激中枢神经,从而起到提高免疫力和保护心脑血管的作用;路路通祛风利水、散结通络,对关节痹痛、腰腿酸痛、麻木痉挛、水肿胀满有奇效。
添加后各原料药的质量百分比为:狗脊20-40%,补骨脂10-30%,骨碎补10-30%,续断5-20%,三七5-15%,丹参3-12%,防己2-10%,香薷2-8%,泽泻1-5%,茯苓1-5%,郁李仁1-5%,龟甲5-15%,柴胡3-15%,透骨草3-8%,川穹2-7%,升麻1-5%,甘草1-3%,路路通1-3%。
也可以为:狗脊20-30%,补骨脂10-20%,骨碎补10-20%,续断5-15%,三七5-10%,丹参3-10%,防己2-8%,香薷2-5%,泽泻1-3%,茯苓1-3%,郁李仁1-3%,金果榄5-10%,熟地黄5-10%,当归3-10%,党参3-8%,黄芪2-7%,大蓟2-5%,桔梗1-3%,鱼腥草1-3%,牛膝1-3%,龟甲5-10%,柴胡3-10%,透骨草3-8%,川穹2-5%,升麻1-5%,甘草1-3%,路路通1-3%。
本发明是利用原料药并通过它们之间各成分的不同配比,产生祛风除湿、补肾强骨、续伤止痛的效果形成一种治疗股骨头坏死的中药组合物,使用该中药组合物,不但能够增加体内钙与磷的含量,有助于消除胀痛和体内的积液,还可以进一步提高身体免疫力并增强体内抗体活性,从而改善人体骨骼的胶原结构,起到很好的促进骨愈合及软骨细胞再生的效果,对针对骨组织变形以及骨内微细血管阻塞,骨质合成减少,钙吸收障碍,骨质疏松等症进行治疗效果明显且无任何副作用。
实施例1
取狗脊400g,补骨脂100g,骨碎补100g,续断50g,三七50g,丹参50g,防己50g,香薷80g,泽泻20g,茯苓50g,郁李仁50g,将组合物研磨成粉末状,制成胶囊口服,每天3次,每次1粒;
然后取狗脊400g,补骨脂100g,骨碎补100g,续断50g,三七50g,丹参50g,防己50g,香薷80g,泽泻20g,茯苓50g,郁李仁50g,将原料放入容器,加冷水漫过药面,浸泡5-10分钟,再加水没过药面采用大火煎煮,沸后用文火熬制10-20分钟后做成膏药外敷在股骨头部位。
实施例2
取狗脊200g,补骨脂300g,骨碎补300g,续断50g,三七50g,丹参30g,防己20g,香薷20g,泽泻10g,茯苓10g,郁李仁10g,按实施例1方式使用。
实施例3
取狗脊250g,补骨脂150g,骨碎补150g,续断80g,三七100g,丹参70g,防己100g,香薷50g,泽泻10g,茯苓20g,郁李仁20g,按实施例1方式使用。
实施例4
取狗脊300g,补骨脂130g,骨碎补120g,续断150g,三七60g,丹参40g,防己70g,香薷30g,泽泻50g,茯苓40g,郁李仁10g,按实施例1方式使用。
实施例5
取狗脊300g,补骨脂100g,骨碎补100g,续断50g,三七50g,丹参30g,防己20g,香薷20g,泽泻10g,茯苓10g,郁李仁10g,金果榄50g,熟地黄50g,当归30g,党参30g,黄芪20g,大蓟20g,桔梗40g,鱼腥草40g,牛膝20g,将组合物研磨成粉末状,制成胶囊口服,每天3次,每次1粒;
然后取狗脊300g,补骨脂100g,骨碎补100g,续断50g,三七50g,丹参30g,防己20g,香薷20g,泽泻10g,茯苓10g,郁李仁10g,金果榄50g,熟地黄50g,当归30g,党参30g,黄芪20g,大蓟20g,桔梗40g,鱼腥草40g,牛膝20g,将原料放入容器,加冷水漫过药面,浸泡5-10分钟,再加水没过药面采用大火煎煮,沸后用文火熬制10-20分钟后做成膏药外敷在股骨头部位。
实施例6
取狗脊200g,补骨脂100g,骨碎补150g,续断100g,三七60g,丹参40g,防己20g,香薷20g,泽泻20g,茯苓20g,郁李仁10g,金果榄50g,熟地黄50g,当归30g,党参30g,黄芪20g,大蓟50g,桔梗10g,鱼腥草10g,牛膝10g,按实施例5方式使用。
实施例7
取狗脊200g,补骨脂100g,骨碎补100g,续断50g,三七50g,丹参30g,防己20g,香薷20g,泽泻10g,茯苓10g,郁李仁10g,龟甲150g,柴胡50g,透骨草50g,川穹50g,升麻50g,甘草30g,路路通20g,将组合物研磨成粉末状,制成胶囊口服,每天3次,每次1粒;
然后取狗脊200g,补骨脂100g,骨碎补100g,续断50g,三七50g,丹参30g,防己20g,香薷20g,泽泻10g,茯苓10g,郁李仁10g,龟甲150g,柴胡50g,透骨草50g,川穹50g,升麻50g,甘草30g,路路通20g,将原料放入容器,加冷水漫过药面,浸泡5-10分钟,再加水没过药面采用大火煎煮,沸后用文火熬制10-20分钟后做成膏药外敷在股骨头部位。
实施例8
取狗脊250g,补骨脂110g,骨碎补140g,续断80g,三七70g,丹参30g,防己20g,香薷50g,泽泻10g,茯苓40g,郁李仁50g,龟甲70g,柴胡100g,透骨草30g,川穹20g,升麻10g,甘草10g,路路通10g,按实施例7方式使用。
实施例9
取狗脊200g,补骨脂100g,骨碎补100g,续断50g,三七50g,丹参30g,防己20g,香薷20g,泽泻10g,茯苓10g,郁李仁10g,金果榄50g,熟地黄50g,当归30g,党参30g,黄芪20g,大蓟20g,桔梗20g,鱼腥草20g,牛膝20g,龟甲50g,柴胡30g,透骨草30g,川穹20g,升麻20g,甘草20g,路路通20g,将组合物研磨成粉末状,制成胶囊口服,每天3次,每次1粒;
然后取狗脊200g,补骨脂100g,骨碎补100g,续断50g,三七50g,丹参30g,防己20g,香薷20g,泽泻10g,茯苓10g,郁李仁10g,金果榄50g,熟地黄50g,当归30g,党参30g,黄芪20g,大蓟20g,桔梗20g,鱼腥草20g,牛膝20g,龟甲50g,柴胡30g,透骨草30g,川穹20g,升麻20g,甘草20g,路路通20g,将原料放入容器,加冷水漫过药面,浸泡5-10分钟,再加水没过药面采用大火煎煮,沸后用文火熬制10-20分钟后做成膏药外敷在股骨头部位。
实施例10
取狗脊250g,补骨脂100g,骨碎补100g,续断50g,三七50g,丹参30g,防己20g,香薷20g,泽泻10g,茯苓10g,郁李仁10g,金果榄50g,熟地黄50g,当归30g,党参30g,黄芪20g,大蓟20g,桔梗10g,鱼腥草10g,牛膝10g,龟甲50g,柴胡10g,透骨草30g,川穹20g,升麻20g,甘草20g,路路通20g,按实施例9方式使用。
Claims (6)
1.治疗股骨头坏死的中药组合物,其特征在于包括以下质量百分比的原料药:狗脊20-40%,补骨脂10-30%,骨碎补10-30%,续断5-20%,三七5-15%,丹参3-12%,防己2-10%,香薷2-8%,泽泻1-5%,茯苓1-5%,郁李仁1-5%。
2.根据权利要求1所述的中药组合物,其特征在于:该组合物的原料药中还包括金果榄,熟地黄,当归,党参,黄芪,大蓟,桔梗,鱼腥草,牛膝。
3.根据权利要求2所述的中药组合物,其特征在于该组合物中各原料药的质量百分比为:狗脊20-40%,补骨脂10-30%,骨碎补10-30%,续断5-20%,三七5-15%,丹参3-12%,防己2-10%,香薷2-8%,泽泻1-5%,茯苓1-5%,郁李仁1-5%,金果榄5-15%,熟地黄5-15%,当归3-15%,党参3-10%,黄芪2-10%,大蓟2-8%,桔梗1-5%,鱼腥草1-5%,牛膝1-5%。
4.根据权利要求1所述的中药组合物,其特征在于:该组合物的原料药中还包括龟甲,柴胡,透骨草,川穹,升麻,甘草,路路通。
5.根据权利要求2所述的中药组合物,其特征在于该组合物中各原料药的质量百分比为:狗脊20-40%,补骨脂10-30%,骨碎补10-30%,续断5-20%,三七5-15%,丹参3-12%,防己2-10%,香薷2-8%,泽泻1-5%,茯苓1-5%,郁李仁1-5%,龟甲5-15%,柴胡3-15%,透骨草3-8%,川穹2-7%,升麻1-5%,甘草1-3%,路路通1-3%。
6.根据权利要求2所述的中药组合物,其特征在于该组合物中各原料药的重量百分比为:狗脊20-30%,补骨脂10-20%,骨碎补10-20%,续断5-15%,三七5-10%,丹参3-10%,防己2-8%,香薷2-5%,泽泻1-3%,茯苓1-3%,郁李仁1-3%,金果榄5-10%,熟地黄5-10%,当归3-10%,党参3-8%,黄芪2-7%,大蓟2-5%,桔梗1-3%,鱼腥草1-3%,牛膝1-3%,龟甲5-10%,柴胡3-10%,透骨草3-8%,川穹2-5%,升麻1-5%,甘草1-3%,路路通1-3%。
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