CN109984773A - Tiny blood vessels inspection and identifying system and method - Google Patents
Tiny blood vessels inspection and identifying system and method Download PDFInfo
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- CN109984773A CN109984773A CN201910233513.XA CN201910233513A CN109984773A CN 109984773 A CN109984773 A CN 109984773A CN 201910233513 A CN201910233513 A CN 201910233513A CN 109984773 A CN109984773 A CN 109984773A
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- A61B8/06—Measuring blood flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0891—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5207—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of raw data to produce diagnostic data, e.g. for generating an image
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Abstract
The invention discloses a kind of tiny blood vessels inspection and identifying system and method, which includes: multiple frequency ultrasonic blood vessel imaging probe, multiple selector, T/R change-over switch, user's control input system, adjustable pulse transmitter, echo receiver, time gain compensation unit, converter, Beam synthesis unit, signal processing unit, image processing unit, vascular test identifying system and display system.Tiny blood vessels inspection and identifying system of the invention detects tiny blood vessels using high frequency ultrasound probe, and use multi-frequency detection probe and supper-fast complex Doppler imaging technique, the detection of extremely low flow velocity tiny blood vessels can be realized woth no need to contrast agent, and it can be according to the needs of different detection zone and different imaging resolution/velocity sensitivities, select different working frequency and operating mode, and there is how general rate dynamic to review and blood vessel micro-structural 3 D Reconstruction of The Function, just doctor observes assessment repeatedly, facilitates diagnosis.
Description
Technical field
The present invention relates to medical instruments field, in particular to a kind of tiny blood vessels inspection and identifying system and method.
Background technique
The existing structure imaging detection to human vas is mainly realized using ultrasound perfusion radiography, and blood flow velocity is adopted more
With ultrasonic Doppler technology.But due to being influenced by supersonic frequency, the blood flow velocity of detection can not generally detect the capillary of low speed
Blood vessel.And clinical research shows to show by small blood flow can determine that tumour and the good malignant nature of lymph node, assesses oncotherapy
Effect；And plaque stability can determine whether by new vessels situation in carotid plaques, that is, judge risk of stroke.But at present
Ultrasonic contrast is relied primarily on to the monitoring of the new vessels of carotid plaques, ultrasonic contrast is a kind of invasive inspection method, valence
About every 650 yuan of lattice, and acoustic contrast agent can cause allergic reaction；By toe position microcirculation situation, the course of disease can be evaluated
Progress and therapeutic evaluation.Therefore, it realizes the imaging of tiny capillaries, and then realizes and it is identified with detection with very heavy
The clinical meaning wanted, social and economic benefit.
Conventional Doppler technology is unable to measure the blood vessel of low flow velocity, in order to realize the speed of the small blood flow of ultrasound detection, closely
Related scholar proposes supper-fast complex Doppler imaging technique (Ultrafast Compound Doppler over year
Imaging).The basic principle is that replacing the focus detection wave in traditional doppler Method using the plane wave of multi-angle transmitting
Beam realizes the high speed measurement to doppler information in a wide range of area-of-interest.And it realizes based on this micro- in tissue
The detection of blood circumstance and the calculating of blood volume (blood volume) in thin vessels (UFFC vol.58, no.1, pp134:
147January 2011)。
Existing ultrasound blood vessel imaging mostly can only be to the high speeds blood flow imaging such as human aortic/vein, and can not be to fine
Capillary imaging.One being since capillary size is small, and existing ultrasonic image-forming system can not be differentiated.Two being due to capillary
Vascular flow rate it is low can not, conventional Doppler method is accurately measured.It is imaged according to contrast agent perfusion, is also only able to detect
Blood vessel signal, and accurately can not be measured and be statisticallyd analyze, seriously hinder the diagnostic analysis of related disease.
Summary of the invention
In view of the above-mentioned deficiencies in the prior art, the technical problem to be solved by the present invention is that providing a kind of tiny blood vessels
It checks and identifying system and method.
In order to solve the above technical problems, the technical solution adopted by the present invention is that: a kind of tiny blood vessels inspection and identifying system,
It include: multiple frequency ultrasonic blood vessel imaging probe, multiple selector, T/R change-over switch, user's control input system, adjustable pulse hair
Emitter, echo receiver, time gain compensation unit, converter, Beam synthesis unit, signal processing unit, image procossing
Unit, vascular test identifying system and display system；
The vascular test identifying system includes mode selection module, blood vessel recognition module, blood flow velocity measurement module, more
General Le playback module, microvessel structure three-dimensional reconstruction module and data calculate analysis and statistical module.
Preferably, the mode selection module includes carrying out check point, detection range, the choosing for checking lesion type
It selects.
Preferably, the blood vessel recognition module includes blood vessel diameter measurement module, blood vessel number statistical module and blood vessel
Distribution measuring module, the distribution for diameter, blood vessel number and blood vessel to blood vessel measure；
The dynamic playback that Doppler's playback module measures for realizing flow Doppler；
The microvessel structure three-dimensional reconstruction module is for realizing the three-dimensional reconstruction for measuring blood vessel.
Preferably, the data calculate analysis and are used for statistical module to blood vessel recognition module, blood flow velocity measurement mould
Block, Doppler's playback module, the processing result of microvessel structure three-dimensional reconstruction module are for statistical analysis, and pass through the display
System shows statistic analysis result.
Preferably, the multiple frequency ultrasonic blood vessel imaging probe includes multiple energy converter groups with different center frequency.
Preferably, each energy converter group parallel arrangement, or in a ring or parallelogram or hexagon or intersection
Line arrangement.
Preferably, the energy converter group list array element, linear array, convex battle array, phased array or face battle array probe；
Preferably, the operating mode of multiple frequency ultrasonic blood vessel imaging probe includes single group mode and multiple groups mode,
In, under multiple groups mode, either whole energy converter groups all work, specific energy converter group work can also be chosen.
Preferably, the tiny blood vessels inspection and the inspection recognition methods of identifying system the following steps are included:
1) first by user according to the position that need to be detected, the multiple frequency ultrasonic is selected by the user's control input system
The operating mode of blood vessel imaging probe, and then joined by the work of adjustable pulse transmitter described in preset process control
Number, the corresponding energy converter group work of multiple selector control, excites the energy converter group transmitting ultrasonic wave；
2) echo-signal of ultrasonic wave is popped one's head in through the multiple frequency ultrasonic blood vessel imaging receives and is converted into electric signal, through T/R
Enter echo receiver after switch to be filtered and enhanced processing, and by the time gain compensation module gain, converter
After conversion enter the Beam synthesis unit complete Beam synthesis, then through the signal processing unit and image processing unit at
After reason, into the vascular test identifying system；
3) as needed by operation doctor, it is carried out by parameter of the vascular test identifying system to the blood vessel in image
The three-dimensional reconstruction of measurement blood vessel is realized in measurement by three-dimensional reconstruction module, then calculates analysis and system by the data
It is for statistical analysis to the measurement result of vascular test identifying system to count module, is as a result shown by the display system；
Wherein, the parameter of blood vessel includes the distribution of blood flow velocity, the diameter of blood vessel, blood vessel number and blood vessel.
Preferably, the running parameter of the adjustable pulse transmitter include driving pulse pulsewidth, centre frequency, amplitude,
Driving pulse pulsewidth and repetition rate.
The beneficial effects of the present invention are: tiny blood vessels inspection of the invention is examined with identifying system using high frequency ultrasound probe
The tiny blood vessels at the positions such as blood vessel, superficial lymph knot, inside tumor are perfused in survey carotid atheroma, between toes, flesh, and adopt
With multi-frequency detection probe and supper-fast complex Doppler imaging technique, the small blood of extremely low flow velocity can be realized woth no need to contrast agent
The detection of pipe, and different works can be selected according to the needs of different detection zone and different imaging resolution/velocity sensitivities
Working frequency and operating mode, and have how general rate dynamic review with blood vessel micro-structural 3 D Reconstruction of The Function, just doctor observes repeatedly
Assessment, facilitates diagnosis.
Detailed description of the invention
Fig. 1 is the structural block diagram of tiny blood vessels inspection of the invention and identifying system；
Fig. 2 is the structural block diagram of vascular test identifying system of the invention；
Fig. 3 is arrangement signal of the energy converter group on multiple frequency ultrasonic blood vessel imaging probe in a kind of embodiment of the invention
Figure.
Description of symbols:
10-multiple frequency ultrasonic blood vessel imagings probe；20-energy converter groups.
Specific embodiment
The present invention will be further described in detail below with reference to the embodiments, to enable those skilled in the art referring to specification
Text can be implemented accordingly.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein are not precluded one or more
The presence or addition of a other elements or combinations thereof.
As shown in Figure 1, a kind of tiny blood vessels inspection and identifying system of the present embodiment, comprising: multiple frequency ultrasonic blood vessel imaging
Probe, multiple selector (MUX), T/R change-over switch, user's control input system, adjustable pulse transmitter, echo receiver,
Time gain compensation unit (TGC), converter, Beam synthesis unit, signal processing unit, image processing unit, blood vessel inspection
Look into identifying system and display system.
Referring to Fig. 2, the vascular test identifying system includes mode selection module, blood vessel recognition module, blood flow velocity survey
It measures module, Doppler's playback module, microvessel structure three-dimensional reconstruction module and data and calculates analysis and statistical module.
Wherein, the mode selection module includes carrying out check point, detection range, the selection for checking lesion type.
Wherein, the blood vessel recognition module includes blood vessel diameter measurement module, blood vessel number statistical module and vascular distribution
Measurement module, the distribution (vessel density etc.) for diameter, blood vessel number and blood vessel to blood vessel measure；
The dynamic playback that Doppler's playback module measures for realizing flow Doppler is commented so that doctor observes repeatedly
Estimate；
The microvessel structure three-dimensional reconstruction module is for realizing the three-dimensional reconstruction for measuring blood vessel.
Wherein, the data calculate analysis and statistical module and are used for blood vessel recognition module, blood flow velocity measurement module, more
General Le playback module, the processing result of microvessel structure three-dimensional reconstruction module are for statistical analysis, and pass through the display system
Show statistic analysis result.
In one embodiment, the multiple frequency ultrasonic blood vessel imaging probe includes multiple transducings with different center frequency
Device group.
In one embodiment, each energy converter group parallel arrangement (such as Fig. 3,4 energy converter groups including parallel arrangement
1,2,3,4), or in a ring or parallelogram or hexagon or cross spider arrangement.Wherein, the energy converter group list array element,
Linear array, convex battle array, phased array or face battle array probe.
In one embodiment, the central frequency range of energy converter are as follows: 1MHz-60MHz.The array number of each energy converter group
Are as follows: 1-512.
In one embodiment, the material of energy converter can be piezoelectric ceramics PZT, piezoelectric monocrystal PMN-PT, AlN etc..
In one embodiment, the operating mode of the multiple frequency ultrasonic blood vessel imaging probe includes single group mode and multiple groups mould
Formula, wherein under multiple groups mode, either whole energy converter groups all work, specific energy converter group work can also be chosen.
In one embodiment, the tiny blood vessels inspection and the inspection recognition methods of identifying system the following steps are included:
1) first by user according to position, detection range, inspection lesion type and the imaging resolution that need to be detected/speed spirit
The specific requirements such as sensitivity select the Working mould of the multiple frequency ultrasonic blood vessel imaging probe by the user's control input system
Formula, and then pass through the running parameter of adjustable pulse transmitter described in preset process control (driving pulse pulsewidth, center frequency
Rate, amplitude, driving pulse pulsewidth and repetition rate etc.), the corresponding energy converter group work of multiple selector control swashs
Transmitting ultrasonic wave of sending out energy converter group described；
2) echo-signal of ultrasonic wave is popped one's head in through the multiple frequency ultrasonic blood vessel imaging receives and is converted into electric signal, through T/R
Enter echo receiver after switch to be filtered and enhanced processing, and by the time gain compensation module gain, converter
After conversion enter the Beam synthesis unit complete Beam synthesis, then through the signal processing unit and image processing unit at
After reason, into the vascular test identifying system；
3) as needed by operation doctor, by the vascular test identifying system to the parameter (blood of the blood vessel in image
The parameter of pipe includes blood flow velocity, the diameter of blood vessel, blood vessel number and distribution of blood vessel etc.) it measures, it is modeled by Three-dimensional Gravity
Block realizes the three-dimensional reconstruction of measurement blood vessel, then calculates analysis and statistical module by the data and identifies to vascular test
The measurement result of system is for statistical analysis, is as a result shown by the display system, uses for diagnosis, wherein Doppler
Playback module is able to achieve the dynamic playback of flow Doppler measurement, and is shown by the display system, can be so as to doctor repeatedly
Observation assessment；
Existing ultrasound blood vessel imaging mostly can only be to the high speeds blood flow imaging such as human aortic/vein, and can not be to fine
Capillary imaging.One being since capillary size is small, and existing ultrasonic image-forming system can not be differentiated.Two being due to capillary
Vascular flow rate it is low can not, conventional Doppler method is accurately measured.It is imaged according to contrast agent perfusion, is also only able to detect
Blood vessel signal, and accurately can not be measured and be statisticallyd analyze, seriously hinder the diagnostic analysis of related disease.The present invention mentions
Tiny blood vessels inspection and identifying system out detects the tiny blood vessels at the positions such as neck, acra using multifrequency high frequency ultrasound probe
Perfusion, and can be according to different detection zones, it can be achieved that the detection of extremely low flow velocity tiny blood vessels can be realized woth no need to contrast agent
With the needs of different imaging resolution/velocity sensitivities, different working frequency and operating mode are selected, and has how general rate dynamic
State is reviewed and the functions such as blood vessel micro-structural 3 D reconstruction.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details.
Claims (10)
1. a kind of tiny blood vessels inspection and identifying system characterized by comprising multiple frequency ultrasonic blood vessel imaging probe, multichannel choosing
Select device, T/R change-over switch, user's control input system, adjustable pulse transmitter, echo receiver, time gain compensation unit,
Converter, Beam synthesis unit, signal processing unit, image processing unit, vascular test identifying system and display system；
The vascular test identifying system includes mode selection module, blood vessel recognition module, blood flow velocity measurement module, Doppler
Playback module, microvessel structure three-dimensional reconstruction module and data calculate analysis and statistical module.
2. tiny blood vessels inspection according to claim 1 and identifying system, which is characterized in that the mode selection module packet
It includes and carries out check point, detection range, the selection for checking lesion type.
3. tiny blood vessels inspection according to claim 2 and identifying system, which is characterized in that the blood vessel recognition module packet
Blood vessel diameter measurement module, blood vessel number statistical module and vascular distribution measurement module are included, for diameter, the blood vessel number to blood vessel
And the distribution of blood vessel measures；
The dynamic playback that Doppler's playback module measures for realizing flow Doppler；
The microvessel structure three-dimensional reconstruction module is for realizing the three-dimensional reconstruction for measuring blood vessel.
4. tiny blood vessels inspection according to claim 3 and identifying system, which is characterized in that the data calculate analysis with
Statistical module is used for blood vessel recognition module, blood flow velocity measurement module, Doppler's playback module, microvessel structure three-dimensional reconstruction
The processing result of module is for statistical analysis, and shows statistic analysis result by the display system.
5. tiny blood vessels inspection according to claim 1 and identifying system, which is characterized in that the multiple frequency ultrasonic blood vessel at
As probe includes multiple energy converter groups with different center frequency.
6. tiny blood vessels inspection according to claim 5 and identifying system, which is characterized in that each energy converter group is parallel
Arrangement, or in a ring or parallelogram or hexagon or cross spider arrangement.
7. tiny blood vessels inspection according to claim 6 and identifying system, which is characterized in that the energy converter group Dan Zhen
Member, linear array, convex battle array, phased array or face battle array probe；
8. tiny blood vessels inspection according to claim 5 and identifying system, which is characterized in that the multiple frequency ultrasonic blood vessel at
As the operating mode of probe includes single group mode and multiple groups mode, wherein under multiple groups mode, either whole energy converter groups
It all works, specific energy converter group work can also be chosen.
9. tiny blood vessels inspection according to claim 8 and identifying system, which is characterized in that the tiny blood vessels inspection with
The inspection recognition methods of identifying system the following steps are included:
1) first by user according to the position that need to be detected, the multiple frequency ultrasonic blood vessel is selected by the user's control input system
The operating mode of imaging probe, and then pass through the running parameter of adjustable pulse transmitter described in preset process control, institute
The corresponding energy converter group work of multiple selector control is stated, the energy converter group transmitting ultrasonic wave is excited；
2) echo-signal of ultrasonic wave is popped one's head in through the multiple frequency ultrasonic blood vessel imaging receives and is converted into electric signal, switchs through T/R
Enter echo receiver afterwards to be filtered and enhanced processing, and is converted by the time gain compensation module gain, converter
Enter the Beam synthesis unit afterwards and complete Beam synthesis, is then handled through the signal processing unit and image processing unit
Afterwards, into the vascular test identifying system；
3) as needed by operation doctor, the parameter of the blood vessel in image is surveyed by the vascular test identifying system
Amount realizes the three-dimensional reconstruction of measurement blood vessel by three-dimensional reconstruction module, then calculates analysis and statistics by the data
Module is for statistical analysis to the measurement result of vascular test identifying system, is as a result shown by the display system；
Wherein, the parameter of blood vessel includes the distribution of blood flow velocity, the diameter of blood vessel, blood vessel number and blood vessel.
10. tiny blood vessels inspection according to claim 1 and identifying system, which is characterized in that the adjustable pulse transmitting
The running parameter of device includes driving pulse pulsewidth, centre frequency, amplitude, driving pulse pulsewidth and repetition rate.
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| CN113476078A (en) * | 2021-07-30 | 2021-10-08 | 江苏医药职业学院 | Vascular nerve detector and vascular nerve detection method under blind surgery |
| US11178494B2 (en) | 2018-01-10 | 2021-11-16 | Goertek Inc. | Sound generating device |
| CN114533127A (en) * | 2022-01-13 | 2022-05-27 | 南京易云医疗设备科技有限公司 | Doppler ultrasonic system for detecting blood vessels |
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Application publication date: 20190709 |