CN106901777A - A kind of multifunction supersonic probe and capilary imaging and VPV detection method - Google Patents
A kind of multifunction supersonic probe and capilary imaging and VPV detection method Download PDFInfo
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- CN106901777A CN106901777A CN201710104008.6A CN201710104008A CN106901777A CN 106901777 A CN106901777 A CN 106901777A CN 201710104008 A CN201710104008 A CN 201710104008A CN 106901777 A CN106901777 A CN 106901777A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
- A61B8/4461—Features of the scanning mechanism, e.g. for moving the transducer within the housing of the probe
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/06—Measuring blood flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0891—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4477—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device using several separate ultrasound transducers or probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- General Health & Medical Sciences (AREA)
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Abstract
The invention discloses a kind of multifunction supersonic probe and capilary imaging and VPV detection method, its multifunction supersonic probe includes the back lining materials, first electrode layer, transducer layer, the second electrode lay and the matching layer that stack gradually from bottom to top；Transducer layer includes low-frequency transducer and high-frequency transducer, and low-frequency transducer is annularly wrapped in the periphery of high-frequency transducer；The low frequency ultrasound detectable signal that low-frequency transducer is launched forms ultraharmonics signal under the scattering process of contrast microbubbles and tissue；Ultraharmonics signal is received by high-frequency transducer, the imaging of external high-resolution, high penetrating power to capilary is realized；The function that microvascular blood flow velocity is detected is realized by launching high-frequency ultrasonic signal；Breaching existing ultrasonic imaging or supersonic blood testing equipment only has single imaging function, or single VPV detects the limitation of function, and greatly improves the resolution ratio of capilary imaging.
Description
Technical field
The invention belongs to ultrasonic imaging technique field, more particularly, to a kind of multifunction supersonic probe and capilary into
Picture and VPV detection method.
Background technology
In biomedicine, capilary plays more and more important role in the diagnosis of disease and body performance,
It is external to realize also increasing the demand of the detection of capilary blur-free imaging and corresponding Hemodynamic environment increasingly.Because ultrasound is with lossless
The advantage of real-time detection, therefore be the main way of medical science detection medium vessels imaging.But due to traditional ultrasonic image-forming system
Resolution ratio it is relatively low, it is impossible to tell capilary, and penetration power higher cannot be obtained using high frequency ultrasound；And, at present
Ultrasonic imaging technique can only be single carrying out detect, it is impossible to realize the dual work(of the detection of imaging and Hemodynamic environment of capilary
Energy；Although and the imaging decay of the low frequency of tissue harmonic is weaker, due to being close to the overlap of valve, causing to there is puppet when low frequency is imaged
Picture, and with the increase of frequency, its decay is increased dramatically, and can not carry out clearly capilary imaging and VPV detection.
The content of the invention
For the disadvantages described above or Improvement requirement of prior art, the invention provides a kind of multifunction supersonic probe and micro- blood
Pipe is imaged and VPV detection method；Its object is to realize reliability evaluation in vitro to capilary；Thus solve existing
Technology is difficult to obtain in vitro high-resolution, the capilary image of high penetrating power and blood flow detection and difunctional integrated asks
Topic.
To achieve the above object, according to one aspect of the present invention, there is provided a kind of multifunction supersonic probe, the probe is
The column structure of single matrix element, including back lining materials, first electrode layer, transducer layer, the second electricity for stacking gradually from bottom to top
Pole layer and matching layer；Wherein, transducer layer includes low-frequency transducer and high-frequency transducer, and low-frequency transducer is annularly wrapped in height
The periphery of frequency transducer；
Wherein, low-frequency transducer is used to launch low frequency ultrasound, and the low frequency ultrasound launched enters blood in a subtle way as detectable signal
Guan Hou, ultraharmonics is generated under the strong scattering effect of contrast microbubbles；High-frequency transducer is then used to receive ultraharmonics signal；Matching layer
For acoustic impedance match reducing loss；Back lining materials are used to adjust acoustic impedance and ultrasonic attenuation coefficient；First electrode layer and
Two electrode layers are respectively used to be high-frequency transducer, low frequency ultrasound transducer cut-in operation voltage.
Preferably, above-mentioned multifunction supersonic probe, the centre frequency of its low frequency ultrasound transducer is 5MHz~10MHz,
The centre frequency of high-frequency transducer is 30MHz~55MHz.
It is another aspect of this invention to provide that there is provided a kind of capilary imaging side based on above-mentioned multifunction supersonic probe
Method, by low frequencies, the double frequency pattern of high-frequency reception, realizes external ultraharmonics capilary imaging, specifically includes following steps：
(1) it is the low frequencies module emission detection signal of 5MHz~10MHz to use centre frequency；
(2) when the detectable signal of transmitting reaches contrast agent, ultraharmonics feedback signal is formed；
(3) use centre frequency that the ultraharmonics signal of feedback is received for the high-frequency receiver of 30MHz~55MHz；
(4) treatment of signal amplification, filtering, analog-to-digital conversion and digitized image is carried out to the ultraharmonics signal for receiving,
Obtain capilary image.
It is another aspect of this invention to provide that there is provided a kind of microvascular blood flow velocity based on above-mentioned multifunction supersonic probe
Detection method, using high frequency mode, high frequency ultrasound is launched by high-frequency transducer, by ultrasonic Doppler effect, is realized
To the blood flow detection of capilary；Specifically include following steps：
(1) it is the high-frequency transducer emission detection signal of 30MHz~55MHz to use centre frequency；
(2) when detectable signal reaches capilary, reflected ultrasonic is formed；Under doppler shift effect, reflectance ultrasound
The frequency that signal compares incident ultrasound changes；
(3) use centre frequency to be received to reflected ultrasonic for the high-frequency receiver of 30MHz~55MHz, obtain
Reflected signal；
(4) signal amplification, filtering, modulus signal conversion are carried out according to the reflected signal for receiving, according to detectable signal
Frequency and reflected signal calculate the VPV for obtaining capilary relative to the frequency displacement of detectable signal.
In general, by the contemplated above technical scheme of the present invention compared with prior art, can obtain down and show
Beneficial effect：
Multifunction supersonic probe and the capilary imaging method based on multifunction supersonic probe that the present invention is provided, profit
Launch low frequency ultrasound signal with low-frequency transducer, scattered by the contrast agent in capilary, form ultraharmonics signal, it is high using it
Frequency transducer receives the signal of 4~5 frequency multiplication therein；Multifunction supersonic probe is carrying out ultrasonic contrast using low frequency signal
4th, the higher hamonic wave imaging of 5 frequencys multiplication, low frequency signal has good penetration power, and in the effect of contrast agent, the high frequency of microvesicle is believed
Number decay it is more slow, there is larger contrast with tissue harmonic imaging, be achieved in the blur-free imaging to capilary；
For compared with the prior art, prior art uses the ultrasonic image-forming system of single low frequencies low frequency reception, though
Right signal attenuation is weaker, but due to being close to the overlap of valve, causes the presence of pseudomorphism when low frequency is imaged, and with the increase of frequency, its
Decay is increased dramatically, it is difficult to obtain the blur-free imaging of capilary；
And this multifunction supersonic probe of the invention, due to 4 in ultrasonic contrast, in the higher hamonic wave of 5 frequencys multiplication, its
It is close to valve in the absence of overlap, therefore artifact problem can be solved, with high penetrating power and high-resolution excellent properties；
On the other hand, the present invention is provided this multifunction supersonic probe and the micro- blood based on multifunction supersonic probe
Pipe VPV detection method, using ultrasonic Doppler effect, by the high-frequency ultrasonic signal for launching, realizes microvascular blood flow speed
Spend the function of detection；Breaching existing ultrasonic imaging or supersonic blood testing equipment only has single imaging function, Huo Zhedan
One VPV detects the limitation of function, is imaged by capilary and microvascular blood flow velocity information, is capable of achieving to capilary
It is reliable to evaluate, there is practical significance in medical science detection, because still lack at present and directly displaying and evaluating organism microcirculation
Imaging method, and the present invention provides technological means for the evaluation to microcirculation.
Brief description of the drawings
Fig. 1 is the structural representation of the multifunction supersonic probe that embodiment is provided；
Fig. 2 is the transducer layer structural representation of the multifunction supersonic probe that embodiment is provided；
Fig. 3 be tissue, microvesicle attenuation characteristic with frequency variation relation schematic diagram；
Fig. 4 ultrasonic doppler blood flow Cleaning Principle schematic diagrames.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.As long as additionally, technical characteristic involved in invention described below each implementation method
Not constituting conflict each other can just be mutually combined.
The multifunction supersonic probe that embodiment is provided is the column structure of single matrix element, including stack gradually from bottom to top
Back lining materials, first electrode layer, transducer layer, the second electrode lay and matching layer, concrete structure are as shown in Figure 1；Wherein, transducer
Layer includes low-frequency transducer and high-frequency transducer, and low-frequency transducer is annularly wrapped in the periphery of high-frequency transducer；Its structure is such as
Shown in Fig. 2；
Wherein, low-frequency transducer is used to launch low frequency ultrasound, and the low frequency ultrasound launched enters blood in a subtle way as detectable signal
Guan Hou, ultraharmonics is generated under the strong scattering effect of contrast microbubbles；High-frequency transducer is then used to receive ultraharmonics signal；Matching layer
For acoustic impedance match reducing loss；Back lining materials are used to adjust acoustic impedance and ultrasonic attenuation coefficient；First electrode layer and
Two electrode layers are respectively used to be accessed for high-frequency transducer, low frequency ultrasound transducer the operating voltage of high-voltage pulse form.
The multifunction supersonic probe that the present embodiment is provided, the centre frequency of its low-frequency transducer is 5MHz, high frequency transducing
The centre frequency of device is 55MHz.
When the multifunction supersonic probe provided using the present embodiment carries out external ultraharmonics capilary imaging, low frequency is changed
The low frequency ultrasound detectable signal that energy device is launched forms ultraharmonics signal under the scattering process of contrast microbubbles and tissue；Due to making
The effect of shadow microvesicle, the ultraharmonics signal of generation is few compared to tissue attenuation, and the decay with tissue forms a sharp contrast；Pass through
High-frequency transducer receives ultraharmonics signal, realizes the imaging of external high-resolution, high penetrating power to capilary；Carried based on embodiment
The method of the capilary imaging of this multifunction supersonic probe for supplying, specifically includes following steps：
(1) it is the low frequencies module emission detection signal of 5MHz to use centre frequency；
(2) the low frequency ultrasound signal of transmitting reaches contrast agent, forms ultraharmonics feedback signal；
(3) use centre frequency carries out reception processing for the high-frequency receiver of 55MHz to the ultraharmonics signal for feeding back, and obtains
Ultraharmonics signal；
(4) according to the ultraharmonics signal for receiving, signal amplification, filtering, modulus signal conversion are carried out, according to the number for obtaining
Word signal is digitized image procossing, obtains capilary image.
The high frequency mode that the multifunction supersonic provided using the present embodiment is popped one's head in, launches high by high-frequency transducer
Frequency ultrasound, is capable of achieving the blood flow detection to capilary under ultrasonic Doppler effect；Specifically include following steps：
(1) it is the high-frequency transducer emission detection signal of 30MHz to use centre frequency；
(2) when the high frequency ultrasound detectable signal of transmitting reaches capilary, reflected ultrasonic is formed；In Doppler frequency shift effect
In the presence of answering, there is frequency displacement change in the frequency that reflected ultrasonic compares incident ultrasound；
(3) use centre frequency carries out reception processing for the high-frequency receiver of 30MHz to reflectance ultrasound, obtains reflection letter
Number；
(4) according to the reflected signal for receiving, signal amplification, filtering, modulus signal conversion are carried out, according to detectable signal
Frequency and reflected signal calculate the VPV for obtaining capilary relative to the frequency displacement of detectable signal.
Below in conjunction with Fig. 3 and Fig. 4, being specifically described the multifunction supersonic probe provided using the present invention carries out external ultraharmonics
The principle that capilary is imaged and microvascular blood flow velocity is detected.
It is relation schematic diagram that tissue, the attenuation characteristic of microvesicle change with frequency, the low frequency imaging of tissue harmonic shown in Fig. 3
When, although decay is weaker, but due to being close to the overlap of valve, causes to there is artifact when low frequency is imaged, and with the increase of frequency,
Its decay is increased dramatically；When the imaging of the higher hamonic wave of 4,5 frequencys multiplication of ultrasonic contrast is carried out, due to the effect of contrast agent, it declines
Subtract more slow, comparing tissue harmonic imaging has larger amplitude.
It is ultrasonic doppler blood flow Cleaning Principle schematic diagram shown in Fig. 4, wherein, f0It is the high frequency ultrasound of transmitting, f refers to connect
The reflected ultrasonic of the endovascular moving particle received, θ is the angle of blood flow and ripple, and according to ultrasonic Doppler effect, it is frequently
MoveWherein v is VPV；C refers to incident wave velocity.
In the present invention, the frequency for using high-frequency transducer emission detection signal is f0, high-frequency ultrasonic signal's arrival of transmitting
Capilary, forming frequency is the reflected ultrasonic of f, and due to the effect of Doppler frequency shift, its transmitting ultrasound compares incident ultrasound
Frequency change, its frequency displacementVPV is obtained accordingly
This multifunction supersonic probe that the present invention is provided, on the one hand launches low frequency ultrasound signal using low-frequency transducer,
Scatter to form ultraharmonics signal by the contrast agent in capilary, the letter of 4~5 frequency multiplication therein is received using its high-frequency transducer
Number, external ultraharmonics imaging is realized, obtain high-resolution capilary image；On the other hand, using ultrasonic Doppler effect, lead to
The high-frequency ultrasonic signal of transmitting is crossed, due to doppler shift effect, the function of microvascular blood flow velocity detection is realized；It is overall and
Speech, the present invention to be obtained following beneficial effect：
(1) imaging of the external capilary of lossless real-time is realized；
(2) high-resolution capilary image is obtained；
(3) the VPV detection to same detection position can synchronously be realized.
As it will be easily appreciated by one skilled in the art that the foregoing is only presently preferred embodiments of the present invention, it is not used to
The limitation present invention, all any modification, equivalent and improvement made within the spirit and principles in the present invention etc., all should include
Within protection scope of the present invention.
Claims (4)
1. a kind of multifunction supersonic is popped one's head in, it is characterised in that the probe is the column structure of single matrix element, including from bottom to top
Back lining materials, first electrode layer, transducer layer, the second electrode lay and the matching layer for stacking gradually；The transducer layer includes low
Frequency transducer and high-frequency transducer, low-frequency transducer are annularly wrapped in the periphery of high-frequency transducer；
The low-frequency transducer is used to launch low frequency ultrasound, after the low frequency ultrasound launched enters capilary as detectable signal,
Ultraharmonics is generated under the strong scattering effect of contrast microbubbles；High-frequency transducer is used to receive ultraharmonics signal；Matching layer is used for sound
Impedance matching is reducing loss；Back lining materials are used to adjust acoustic impedance and ultrasonic attenuation coefficient；First electrode layer and second electrode
Layer is respectively used to be high-frequency transducer, low frequency ultrasound transducer cut-in operation voltage.
2. multifunction supersonic as claimed in claim 1 is popped one's head in, it is characterised in that the centre frequency of the low frequency ultrasound transducer
It is 5MHz~10MHz, the centre frequency of high-frequency transducer is 30MHz~55MHz.
3. the capilary imaging method that a kind of multifunction supersonic based on described in claim 1~2 is popped one's head in, it is characterised in that logical
Low frequencies, the double frequency pattern of high-frequency reception are crossed, external ultraharmonics capilary imaging is realized；Specifically include following steps：
(1) it is the low frequencies module emission detection signal of 5MHz~10MHz to use centre frequency；
(2) when the detectable signal of transmitting reaches contrast agent, ultraharmonics feedback signal is formed；
(3) use centre frequency that the ultraharmonics signal of feedback is received for the high-frequency receiver of 30MHz~55MHz；
(4) treatment of signal amplification, filtering, analog-to-digital conversion and digitized image is carried out to the ultraharmonics signal for receiving, is obtained
Capilary image.
4. the microvascular blood flow velocity detection method that a kind of multifunction supersonic based on described in claim 1~2 is popped one's head in, its feature
It is to comprise the following steps：
(1) it is the high-frequency transducer emission detection signal of 30MHz~55MHz to use centre frequency；
(2) when detectable signal reaches capilary, reflected ultrasonic is formed；Under doppler shift effect, reflected ultrasonic
The frequency for comparing incident ultrasound changes；
(3) use centre frequency to be received to reflected ultrasonic for the high-frequency receiver of 30MHz~55MHz, reflected
Signal；
(4) signal amplification, filtering, modulus signal conversion are carried out according to the reflected signal for receiving, according to the frequency of detectable signal
And reflected signal calculates the VPV for obtaining capilary relative to the frequency displacement of detectable signal.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710104008.6A CN106901777A (en) | 2017-02-24 | 2017-02-24 | A kind of multifunction supersonic probe and capilary imaging and VPV detection method |
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| CN201710104008.6A CN106901777A (en) | 2017-02-24 | 2017-02-24 | A kind of multifunction supersonic probe and capilary imaging and VPV detection method |
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Cited By (7)
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| CN107260213A (en) * | 2017-07-04 | 2017-10-20 | 中国科学院苏州生物医学工程技术研究所 | Ultrasonic probe and apply its ultrasonic image-forming system |
| WO2019119400A1 (en) * | 2017-12-22 | 2019-06-27 | 深圳先进技术研究院 | Dual-frequency intravascular ultrasonic imaging probe |
| CN109984773A (en) * | 2019-03-26 | 2019-07-09 | 中国科学院苏州生物医学工程技术研究所 | Tiny blood vessels inspection and identifying system and method |
| CN110477953A (en) * | 2018-07-16 | 2019-11-22 | 华中科技大学 | A kind of double-frequency ultrasound energy converter |
| EP3675742A4 (en) * | 2017-09-01 | 2021-05-12 | Fujifilm Sonosite, Inc. | Dual frequency plane wave ultrasound imaging system |
| CN113616245A (en) * | 2021-08-30 | 2021-11-09 | 深圳欢影医疗科技有限公司 | Imaging method and system based on multi-frequency ultrasonic transducer |
| CN114098813A (en) * | 2020-08-28 | 2022-03-01 | 深圳迈瑞生物医疗电子股份有限公司 | Ultrasonic imaging method, device and storage medium |
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Application publication date: 20170630 |