CN106175838A - A kind of ultrasonic sclerotin diagnostic system of back scattering based on array probe - Google Patents
A kind of ultrasonic sclerotin diagnostic system of back scattering based on array probe Download PDFInfo
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- CN106175838A CN106175838A CN201610805715.3A CN201610805715A CN106175838A CN 106175838 A CN106175838 A CN 106175838A CN 201610805715 A CN201610805715 A CN 201610805715A CN 106175838 A CN106175838 A CN 106175838A
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- 239000000523 sample Substances 0.000 title claims abstract description 75
- 108010048734 sclerotin Proteins 0.000 title claims abstract description 20
- 238000001514 detection method Methods 0.000 claims abstract description 25
- 238000006243 chemical reaction Methods 0.000 claims abstract description 16
- 238000002604 ultrasonography Methods 0.000 claims abstract description 12
- 238000002955 isolation Methods 0.000 claims abstract description 11
- 230000010354 integration Effects 0.000 claims abstract description 4
- 230000008878 coupling Effects 0.000 claims description 20
- 238000010168 coupling process Methods 0.000 claims description 20
- 238000005859 coupling reaction Methods 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 20
- 239000011241 protective layer Substances 0.000 claims description 17
- 210000000988 bone and bone Anatomy 0.000 claims description 12
- 238000003745 diagnosis Methods 0.000 claims description 5
- 238000010030 laminating Methods 0.000 claims description 3
- 238000005086 pumping Methods 0.000 claims description 3
- 230000003595 spectral effect Effects 0.000 claims description 3
- 238000012360 testing method Methods 0.000 claims description 3
- 238000012546 transfer Methods 0.000 claims description 3
- 230000002463 transducing effect Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 abstract description 6
- 230000005284 excitation Effects 0.000 abstract description 2
- 239000007822 coupling agent Substances 0.000 description 6
- 230000005540 biological transmission Effects 0.000 description 3
- 210000000459 calcaneus Anatomy 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 210000003423 ankle Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011378 penetrating method Methods 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0875—Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of bone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Abstract
The invention belongs to Medical Instruments technical field, be specially the ultrasonic sclerotin diagnostic system of back scattering based on array probe.Present system includes: arm processor, FPGA, LCD display, multichannel analog to digital conversion circuit, multichannel high_voltage isolation receive circuit, multichannel high-voltage pulse radiating circuit, pressure sensor detection circuit, integrative ultrasonic probe.The present invention uses the ultrasonic array probe of integration to detect sclerotin, each miniature ultrasonic transducer excitation ultrasound pulse respectively in array also receives backscatter signal, complete the sclerotin detection of each location point, by processor, the diagnostic result of each point is averaged the most again, thus improves accuracy and the stability of measurement data；On the other hand, plus pressure sensor circuit around ultrasonic probe array, the pressure between detection ultrasonic probe and detected part, only when this force value within the limits prescribed time carry out ultrasound detection, thus improve the stability of diagnostic result.
Description
Technical field
The invention belongs to Medical Instruments technical field, be specifically related to a kind of ultrasonic sclerotin of back scattering based on array probe and examine
Disconnected system.
Background technology
Ultrasonic because of its distinctive lossless, without ionizing radiation, the advantage such as real-time, inexpensive and portable it is considered to be sclerotin diagnosis
The method of great potential.The ultrasonic diagnosis method of sclerotin is broadly divided into Ultrasonic logging method and back dispersion method.Ultrasonic logging method develops
Relatively early, it is widely used at present, and MEASUREMENT OF ULTRASONIC BACKSCATTERING method is the most increasingly being paid close attention to by research worker.With transmission
Method is compared, and MEASUREMENT OF ULTRASONIC BACKSCATTERING method has the advantage that back dispersion method can reflect bone micro-structure information；Have only to single ultrasonic spy
Head carries out receiving and dispatching and needs one one to receive two probes unlike transmission beam method；It is possible not only at human body calcaneus measure,
Can also measure at other skeletal sites.But in the middle of actually used process, either Ultrasonic logging method, or the ultrasonic back of the body dissipates
Penetrating method, its measurement result is affected by probe laminate pressure, putting position the most to a certain extent.At calcaneus, carry out the back of the body dissipate
When penetrating method detection, if probe is fitted the tightst with ankle, then cannot receive correct ultrasonic backscattered signal；And if visited
Head is excessive with the pressure of ankle laminating, then can change thickness and the density of soft tissue, also have the result of detection of backscatter signal
A certain degree of impact.On the other hand, the poorest due to the bone micro-structure of calcaneus diverse location point, soft tissue thickness, density
Different, therefore the testing result at diverse location point has some differences.Above-mentioned two reason reduces the detection of MEASUREMENT OF ULTRASONIC BACKSCATTERING method
Accuracy and stability.
Summary of the invention
The accuracy back scattering ultrasonic sclerotin diagnosis high, good stability that it is an object of the invention to provide a kind of detection is
System.
The back scattering ultrasonic sclerotin diagnostic system that the present invention provides, based on array probe, including: arm processor,
FPGA, LCD display, multichannel analog to digital conversion circuit, multichannel high_voltage isolation receive circuit, multichannel high-voltage pulse radiating circuit, pressure
Force transducer testing circuit, integrative ultrasonic are popped one's head in；Wherein:
Described integrative ultrasonic is popped one's head in by probing shell protective layer, miniature ultrasonic linear transducer array, pressure transducer and coupling liquid
Constitute.Miniature ultrasonic linear transducer array is enclosed in the probing shell protective layer of full coupling liquid, and each miniature ultrasonic probe can
To send independently, to receive ultrasonic signal；Pressure transducer buries below the probing shell protective layer of outer ring, for detection one
Pressure between body ultrasonic probe and bone sample to be measured.Wherein, ultrasonic probe number N, can be 5-25, an embodiment
In be 9；In ultrasonic probe array, probe is arranged in the figure of symmetry.
Described pressure sensor detection circuit is for measuring the impedance between pressure transducer electrode, thus detects pressure
Value, and it is converted into digital signal by analog to digital conversion circuit；FPGA reads this force value, and by bus transfer to ARM
Processor.This force value is shown over the display by arm processor, and points out user to adjust this pressure in correct scope.
Run software program on described arm processor, by high speed bus interface FPGA be controlled and obtain data；
First FPGA controls pressure sensor detection circuit and obtains the pressure value of integrative ultrasonic detecting head surface, and arm processor should
Pressure value shows on the interface of LCD display, to point out user to increase or to reduce the pressure of probe laminating；When force value exists
Time in the range of Zheng Que, FPGA controls multichannel high-voltage pulse radiating circuit, drives each miniature ultrasonic probe to send ultrasound wave successively
Pulse signal, and the high_voltage isolation controlling respective channels receives circuit and high-speed A/D conversion circuit gathers backscatter signal；
The each road ultrasonic backscattered signal received is uploaded to arm processor by high-speed bus by FPGA.
Work process is as follows with principle: when the force value that pressure sensor detection circuit detects is in the range of correct,
FPGA controls multichannel high-voltage pulse radiating circuit and controls first miniature ultrasonic transducer transmission ultrasonic pulse pumping signal；This surpasses
Sound wave is by the interface between miniature ultrasonic transducer and coupling liquid, then passes through the boundary between coupling liquid and probe protective layer
Face, then penetrates ultrasonic coupling agent and arrives bone sample to be measured；There is back scattering in ultrasound wave in bone sample, the back scattering of generation is returned
Ripple signal penetrates ultrasonic coupling agent, then by the interface between probe protective layer and coupling liquid, then by coupling liquid with
Interface between miniature ultrasonic transducer, is received and converted to the signal of telecommunication by miniature ultrasonic transducer.FPGA controls multichannel high pressure
Isolation receives circuit and receives the signal of respective channel, and is filtered, amplifies, then controls the correspondence in multichannel analog to digital conversion circuit
Passage carries out analog digital conversion, gathers the backscatter signal of this passage.Subsequently, FPGA repeats said process, controls other successively and leads to
The signal of road miniature ultrasonic probe sends and receives.
After the ultrasonic backscattered signal collecting whole N number of passage, these signals are sent by FPGA by high-speed bus
To arm processor.The backscatter signal that each miniature ultrasonic probe is received by arm processor, calculates the apparent integration back of the body respectively
Scattering coefficient (AIB), back scattering spectral centroid skew multiple backscatter parameters such as (SCS), backscattering coefficient (BSC), and to this
The result of calculation of a little miniature ultrasonic probe passages is averaged, and sclerotin situation is paid a home visit by the backscatter parameters after foundation is average
Disconnected, and show on an lcd display.
The novelty of the present invention is: 1) use ultrasonic array probe to detect sclerotin, each small-sized in array
Ultrasonic transducer excitation ultrasound pulse respectively also receives backscatter signal, respectively each location point is carried out sclerotin detection, then
By arm processor, the diagnostic result of each point is averaged again, thus improves accuracy and the stability of measurement data.2) super
Using pressure sensor circuit around sonic probe array, the pressure between detection ultrasonic probe and detected part, only when this pressure
Carry out ultrasound detection when being worth within the limits prescribed, thus improve the stability of diagnostic result.
The present invention is very different with existing supersonic array imaging device based on ultrasonic reflection principle.Existing based on
The imaging device of supersonic array, is to launch ultrasound wave, then by the width of reflection wave signal by measuring targets on each point
Degree is converted to pixel value, thus carries out imaging.This technology with only this single scalar letter of amplitude of reflection wave signal
Breath.And the present invention is when using the probe of each miniature ultrasonic in supersonic array, acquisition is complete back scattering waveform, by whole
Individual waveshape goes out backscatter parameters.The present invention uses supersonic array, is in order to the result detecting multiple diverse location points is entered
Row zone leveling, thus improve accuracy and the stability of back dispersion method detection.Additionally, the present invention uses pressure transducer with inspection
Survey the pressure between integrative ultrasonic probe and testee, thus ensure that during detection every time, laminate pressure is in the reasonable scope,
Improve stability and the repeatability of detection.
Accompanying drawing explanation
The present invention is further described with embodiment below in conjunction with the accompanying drawings.
Fig. 1 is the structure chart of the ultrasonic sclerotin diagnostic system of a kind of based on linear transducer array back scattering of the present invention.
Fig. 2 is the structure chart of the integrative ultrasonic probe in the present invention.In Fig. 2, for mapping clear, only draw 3 small-sized
Ultrasonic probe.9 probes are used to constitute 3*3 array, as shown in Figure 3 in one embodiment.
Fig. 3 is the top view structure chart of the integrative ultrasonic probe in the present invention.
Label in figure: 1 is arm processor, 2 is FPGA, and 3 is multichannel analog to digital conversion circuit, and 4 receive for multichannel high_voltage isolation
Circuit, 5 is pressure sensor detection circuit, and 6 is multichannel high-voltage pulse radiating circuit, 7 integrated ultrasonic probes, and 8 is ultrasonic
Couplant, 9 is bone sample.7.1 is probing shell protective layer, and 7.2 is pressure transducer, and 7.3 is pressure transducer electrode, 7.4
For miniature ultrasonic linear transducer array, 7.5 is miniature ultrasonic probe electrode, and 7.6 is coupling liquid, and 7.7 is probing shell inwall.
Detailed description of the invention
As it is shown in figure 1, the ultrasonic sclerotin diagnostic system of back scattering based on linear transducer array of the present invention includes: arm processor
1, FPGA2, multichannel analog to digital conversion circuit 3, multichannel high_voltage isolation receive circuit 4, pressure sensor detection circuit 5, multichannel high pressure
Impulse ejection circuit 6, integrative ultrasonic probe 7, ultrasonic coupling agent 8.
As shown in Figures 2 and 3, the integrative ultrasonic probe in the present invention includes: probing shell protective layer 7.1, and pressure passes
Sensor 7.2, pressure transducer electrode 7.3, miniature ultrasonic linear transducer array 7.4, miniature ultrasonic probe electrode 7.5, coupling liquid
7.6, probing shell inwall 7.7.In figure, integrative ultrasonic probe can be divided into inner ring and outer ring two parts.Probe at inner ring
Below protective layer 7.1, with probing shell inwall 7.7 as border, it it is a circular cylindrical cavity.Coupling liquid it is full of in this cavity
7.6.In the present embodiment, the coupling liquid 7.6 of employing is the water solublity high score with electrical isolation capabilities and low acoustic attenuation coefficient
Sub-gel.In cavity, place miniature ultrasonic linear transducer array 7.4, be close to probing shell protective layer 7.1 upper wall.Array is popped one's head in
It is arranged in the figure of symmetry, in the present embodiment, uses 9 miniature ultrasonic probes, be arranged in the array of 3*3, as shown in Figure 3.
Miniature ultrasonic probe electrode 7.5 is by drawing bottom probe.In the present embodiment, pressure transducer 7.2 uses metal strain plate
Type pressure transducer, is buried in the outer ring of probing shell protective layer 7.1, to avoid stopping the letter of miniature ultrasonic probe 7.4
Number send with receive.Pressure transducer electrode 7.3 is hidden in chamber outer wall, by drawing bottom probe.
When integrative ultrasonic probe 7 is pressed in bone sample 9 surface to be measured, the metal strain sector-meeting in pressure transducer 7.2
Produce deformation, thus cause the change of metal strain plate impedance.Pressure sensor detection circuit 5 is surveyed by the way of stream is sought in pressurization
Impedance between piezometric force sensor electrode 7.3, thus detect force value, and analog digital conversion is digital signal.FPGA2 reads should
Force value, and by bus transfer to arm processor 1.This force value is shown over the display by arm processor 1, and points out use
Family adjusts this pressure in correct scope.
When this force value is in the range of correct, FPGA2 controls multichannel high-voltage pulse radiating circuit 6 and controls miniature ultrasonic spy
First probe in head array 7.4 sends ultrasonic pulse pumping signal.This ultrasound wave is popped one's head in by miniature ultrasonic and coupling liquid
Interface between body 7.6, then by the interface between coupling liquid 7.6 and probe protective layer 7.1, then penetrate ultrasonic coupling agent
8 arrive bone sample 9 to be measured.There is back scattering in ultrasound wave in bone sample 9, the back scattering echo-signal of generation penetrates ultrasonic coupling
Agent 8, then by the interface between probe protective layer 7.1 and coupling liquid 7.6, then by coupling liquid 7.6 and miniature ultrasonic
Interface between probe 7.4, is received and converted to the signal of telecommunication by miniature ultrasonic probe 7.4.FPGA2 controls multichannel high_voltage isolation and connects
Receive circuit 4 and receive the signal of respective channel, and be filtered, amplify, then control the respective channel in multichannel analog to digital conversion circuit 3
Carry out analog digital conversion, gather the backscatter signal of this passage.Subsequently, FPGA2 repeats said process, controls other passages successively little
The signal of type ultrasonic probe sends and receives.
After the ultrasonic backscattered signal collecting whole 9 passages, these signals are sent by FPGA2 by high-speed bus
To arm processor 1.Arm processor 1 backscatter signal of each passage is calculated respectively apparent integration backscattering coefficient (AIB),
The back scattering spectral centroid skew backscatter parameters such as (SCS), backscattering coefficient (BSC), then calculates knot to the parameter of 9 passages
Fruit is averaged.Backscatter parameters after foundation is average, makes diagnosis, and shows in LCD display 10 sclerotin situation.
In the present embodiment, arm processor 1 is communicated by high speed bus interface with FPGA2.Arm processor 1 passes through
This bus is to FPGA2 transmitting control commands, and reads the backscatter signal collected from FPGA2.This bus can use at ARM
The external parallel bus of reason device or universal serial bus, have employed SPI universal serial bus in the present embodiment.Arm processor 1 will collect
Waveform, pressure transducer detected value and calculate the information such as diagnostic result and show in LCD display 10.
In the present embodiment, the miniature ultrasonic center probe frequency of employing is 3.5MHz, the ultrasonic pulsative signal frequency of transmitting
Rate is produced by FPGA2 internal logic, is likewise configured to 3.5MHz.Ultrasonic coupling agent 8 uses generally use in ultrasound medicine to surpass
Acoustic couplant.
Claims (3)
1. the ultrasonic sclerotin diagnostic system of back scattering based on array probe, it is characterised in that including: arm processor,
FPGA, LCD display, multichannel analog to digital conversion circuit, multichannel high_voltage isolation receive circuit, multichannel high-voltage pulse radiating circuit, pressure
Force transducer testing circuit, integrative ultrasonic are popped one's head in；Wherein:
Described integrative ultrasonic is popped one's head in by probing shell protective layer, miniature ultrasonic linear transducer array, pressure transducer and coupling liquid
Constitute；Miniature ultrasonic linear transducer array is enclosed in the probing shell protective layer of full coupling liquid, and each miniature ultrasonic probe can
To send independently, to receive ultrasonic signal；Pressure transducer buries below the probing shell protective layer of outer ring, for detection one
Pressure between body ultrasonic probe and bone sample to be measured；
Described pressure sensor detection circuit is for measuring the impedance between pressure transducer electrode, thus detects force value, and
It is converted into digital signal by analog to digital conversion circuit；FPGA reads this force value, and by bus transfer to ARM process
Device；This force value is shown over the display by arm processor, and points out user to adjust this pressure in correct scope；
Run software program on described arm processor, by high speed bus interface FPGA be controlled and obtain data；FPGA
First controlling pressure sensor detection circuit and obtain the pressure value of integrative ultrasonic detecting head surface, arm processor is by this pressure
Numerical value shows on the interface of LCD display, to point out user to increase or to reduce the pressure of probe laminating；When force value is correctly
In the range of time, FPGA controls multichannel high-voltage pulse radiating circuit, drive successively each miniature ultrasonic probe send ultrasonic pulse
Signal, and the high_voltage isolation controlling respective channels receives circuit and high-speed A/D conversion circuit gathers backscatter signal；FPGA will
The each road ultrasonic backscattered signal received is uploaded to arm processor by high-speed bus.
The ultrasonic sclerotin diagnostic system of back scattering based on array probe the most according to claim 1, it is characterised in that system
Work process is as follows: when the force value that pressure sensor detection circuit detects is in the range of correct, it is high that FPGA controls multichannel
Pressure impulse ejection circuit controls first miniature ultrasonic transducer and sends ultrasonic pulse pumping signal；This ultrasound wave is by small-sized super
Interface between sonic transducer and coupling liquid, then by the interface between coupling liquid and probe protective layer, then penetrate super
Acoustic couplant arrives bone sample to be measured；There is back scattering in ultrasound wave in bone sample, the back scattering echo-signal of generation penetrates super
Acoustic couplant, then by the interface between probe protective layer and coupling liquid, then by coupling liquid and miniature ultrasonic transducing
Interface between device, is received and converted to the signal of telecommunication by miniature ultrasonic transducer；FPGA controls multichannel high_voltage isolation and receives circuit
Receive the signal of respective channel, and be filtered, amplify, then control the respective channel in multichannel analog to digital conversion circuit and carry out modulus
Conversion, gathers the backscatter signal of this passage；FPGA repeats said process, controls the letter of other passage miniature ultrasonic probe successively
Number send with receive.
The ultrasonic sclerotin diagnostic system of back scattering based on array probe the most according to claim 2, it is characterised in that adopting
After collection arrives the ultrasonic backscattered signal of whole passages, these signals are sent to arm processor by high-speed bus by FPGA；ARM
The backscatter signal that each miniature ultrasonic probe is received by processor, calculates apparent integration backscattering coefficient, back scattering respectively
Spectral centroid skew, backscattering coefficient, and the result of calculation of these miniature ultrasonic probe passage is averaged, after average
Backscatter parameters, sclerotin situation is made diagnosis, and shows on an lcd display.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610805715.3A CN106175838B (en) | 2016-09-07 | 2016-09-07 | Backscattering ultrasonic bone diagnosis system based on array probe |
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| CN201610805715.3A CN106175838B (en) | 2016-09-07 | 2016-09-07 | Backscattering ultrasonic bone diagnosis system based on array probe |
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| CN106175838A true CN106175838A (en) | 2016-12-07 |
| CN106175838B CN106175838B (en) | 2023-09-08 |
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| CN110769754A (en) * | 2017-06-21 | 2020-02-07 | 夏里特柏林大学医学院 | System, method and computer program product for determining cortical bone |
| CN108030512A (en) * | 2017-12-21 | 2018-05-15 | 福州大学 | A kind of supersonic array measuring method of ankle arthrosis degree of injury |
| CN109009225A (en) * | 2018-07-25 | 2018-12-18 | 中国科学院苏州生物医学工程技术研究所 | Bone detection method, device and borne densitometers |
| CN111839591A (en) * | 2019-04-29 | 2020-10-30 | 苏州触达信息技术有限公司 | Wearable equipment and system based on ultrasonic monitoring blood velocity of flow |
| CN114533125A (en) * | 2022-03-21 | 2022-05-27 | 西安工业大学 | Bone detection system based on flexible sensor and detection method thereof |
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