CN109975276A - Control method, system and the chemiluminescence detector of chemiluminescence detector - Google Patents

Control method, system and the chemiluminescence detector of chemiluminescence detector Download PDF

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Publication number
CN109975276A
CN109975276A CN201711462165.0A CN201711462165A CN109975276A CN 109975276 A CN109975276 A CN 109975276A CN 201711462165 A CN201711462165 A CN 201711462165A CN 109975276 A CN109975276 A CN 109975276A
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China
Prior art keywords
reaction vessel
disc mechanism
time
operating time
reaction
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CN201711462165.0A
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CN109975276B (en
Inventor
汤俊辉
邱小明
吴锦洪
胡毅
李江
刘芬
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Shenzhen New Industries Biomedical Engineering Co Ltd
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Shenzhen New Industries Biomedical Engineering Co Ltd
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Publication of CN109975276A publication Critical patent/CN109975276A/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence

Abstract

The present invention provides a kind of control method of chemiluminescence detector, method includes the following steps: the test item information for obtaining each reaction vessel on chemiluminescence detector；Judge whether the first reaction vessel buffered on disc mechanism will execute same object run with each second reaction vessel reacted on disc mechanism within the same period respectively；Judge to buffer whether each third reaction vessel on the first reaction vessel and cleaning device on disc mechanism will execute same object run within the same period respectively；If the first reaction vessel and more than one second reaction vessel and/or more than one third reaction vessel, same object run will be executed within the same period, then will postpone to execute that the first reaction vessel punched disc mechanism of postponing is transferred to the operation of reaction disc mechanism.Control method, system and the chemiluminescence detector of chemiluminescence detector of the invention solve the resource transfer conflict in detection process, improve the detection efficiency of the chemiluminescence detector.

Description

Control method, system and the chemiluminescence detector of chemiluminescence detector
Technical field
The present invention relates to chemiluminescence detection technology fields, more particularly to a kind of controlling party of chemiluminescence detector Method, system and chemiluminescence detector.
Background technique
Chemiluminescence immunoassay is a kind of vitro detection for being combined antigen-antibody immune response and luminescence-producing reaction Analytical technology, it is based on Immunology, a variety of to detect by collecting optical signal using luminous marker as tracer signal Marker has high sensitivity, the advantage that non-specific adsorption is low, accuracy rate is high.With the high speed development of biological medicine equipment, Realize that the full-automation of chemiluminescence detector has certain condition.
Chemiluminescence detector mainly includes reaction cup loading device, dispenser, reagent storage means, incubation reaction dress It sets, cleaning device, measuring device etc., wherein dispenser, reagent storage means, cleaning device and measuring device etc. are set Set in the side of incubation reaction device, and the side of incubation reaction device be provided with dispenser, reagent storage means with And the corresponding reaction station such as cleaning device.When incubation reaction device drives the reaction cup loaded thereon to turn to each reaction work When position, which can act and complete corresponding operation.In synchronization, when more than two reactions When cup needs to be implemented identical operation, for example, two reaction cups are required to carry out reagent adding operation using same reagent needle, then can There is resource transfer conflict, results even in instrument and lock, to will affect the detection efficiency of instrument.
Summary of the invention
In view of the status of the prior art, the purpose of the present invention is to provide a kind of control method of chemiluminescence detector, System and chemiluminescence detector, the resource transfer conflict being able to solve in detection process, improve the chemiluminescence detector Detection efficiency.
To achieve the above object, the present invention adopts the following technical scheme:
A kind of control method of chemiluminescence detector, described method includes following steps:
Obtain the test item information of each reaction vessel on chemiluminescence detector, wherein the test item letter Operating time needed for breath includes the multiple object runs executed needed for the reaction vessel and completes each object run；
According to the test item information of each reaction vessel, judgement buffers the first reaction vessel on disc mechanism respectively Whether same object run will be executed within the same period with each second reaction vessel reacted on disc mechanism；
According to the test item information of each reaction vessel, judgement buffers the first reaction vessel on disc mechanism respectively Whether same object run will be executed within the same period with each third reaction vessel on cleaning device；
If first reaction vessel and more than one second reaction vessel and/or the more than one third Reaction vessel will execute same object run within the same period, then postpone to execute first reaction vessel from described Buffering disc mechanism is transferred to the operation of the reaction disc mechanism.
In one embodiment, according to the test item information of each reaction vessel, judgement buffers disc mechanism respectively On the first reaction vessel whether will be executed within the same period with each second reaction vessel reacted on disc mechanism it is same The step of object run, comprising:
According to the test item information of first reaction vessel, obtains first reaction vessel and moved from current location To the first operating time with current goal operation corresponding position；
Respectively according to the test item information of each second reaction vessel, obtain each second reaction vessel from Current location moves to the second operating time of the current goal operation corresponding position；
If first operating time, second operating time corresponding with more than one second reaction vessel Time interval within a preset time, then determine that first reaction vessel and second reaction vessel will be in the same periods It is interior to execute same object run；
Wherein, the preset time is the operating time needed for completing the current goal operation.
In one embodiment, the method also includes following steps:
If first operating time, second operating time corresponding with more than one second reaction vessel It is equal, then determine that first reaction vessel and second reaction vessel will execute same target within the same period and grasp Make.
In one embodiment, current goal operation for will be completed incubate operation reaction vessel be transferred to it is described The cleaning transfer operation of cleaning device, the preset time include the first preset time, and the method also includes following steps:
If first operating time and more than one second reaction vessel corresponding second operating time Time interval in first preset time, then determine that first reaction vessel will be same with second reaction vessel The cleaning transfer operation is executed in one period；
Wherein, first preset time grabs cup mechanism for cleaning and one reaction vessel is transferred to institute from reaction disc mechanism State the time expended needed for cleaning device；
First operating time is that first reaction vessel expends needed for from current location to completion incubation operation Time；
Second operating time is that second reaction vessel completes temperature from current location to second reaction vessel Educate the time expended needed for operation.
In one embodiment, the current goal operation is transferred to described delay for that will react reaction vessel on outer disc mechanism The sample transfer operation of punched disc mechanism, the preset time include the second preset time, and the method also includes following steps:
If first operating time and more than one second reaction vessel corresponding second operating time Time interval in second preset time, then determine that first reaction vessel will be same with second reaction vessel The sample transfer operation is executed in one period；
Wherein, second preset time grabs cup mechanism for sample and is transferred to a reaction vessel from outer disc mechanism is reacted The time expended needed for the buffering disc mechanism；
First operating time is turn that first reaction vessel moves to buffering disc mechanism side from current location Move the time expended needed for cup position；
Second operating time moves to disc mechanism week outside the reaction from current location for second reaction vessel Side plus the required consuming of cup station time.
The current goal operation is that reagent adding operates in one of the embodiments, and the preset time includes third Preset time, the method also includes:
If first operating time and more than one second reaction vessel corresponding second operating time Between time interval in the third preset time, then determine that first reaction vessel and second reaction vessel will The reagent adding operation is executed within the same period；
Wherein, the third preset time is the operating time needed for completing the reagent adding operation；
First operating time is that first reaction vessel is moved from current location to the reaction disc mechanism side The time expended needed for the reagent adding station of setting；
Second operating time is that second reaction vessel moves to needed for the reagent adding station from current location The time of consuming.
In one embodiment, according to the test item information of each reaction vessel, judgement buffers disc mechanism respectively On the first reaction vessel and cleaning device on each third reaction vessel whether same mesh will be executed within the same period The step of mark operation, further includes:
According to the test item information of first reaction vessel, obtains first reaction vessel and moved from current location To the first operating time with current goal operation corresponding position；
Respectively according to the test item information of the third reaction vessel, each third reaction vessel is obtained from current Position moves to the third operating time with current goal operation corresponding position；
If the third operating time corresponding with the more than one third reaction vessel first operating time Time interval within a preset time, then determine that first reaction vessel and the third reaction vessel will be in the same periods It is interior to execute same object run.
In one embodiment, the method also includes following steps:
If the third operating time corresponding with the more than one third reaction vessel first operating time It is equal, then determine that first reaction vessel and the third reaction vessel will execute same target within the same period and grasp Make.
In one embodiment, the current goal operation is that reagent adding operates, and the preset time includes the 4th default Time, the method also includes:
If first operating time and the more than one third reaction vessel corresponding third operating time Between time interval in the 4th preset time, then determine that first reaction vessel and the third reaction vessel will The reagent adding operation is executed within the same period；
Wherein, the 4th preset time is the operating time needed for completing the reagent adding operation；
First operating time is that first reaction vessel is moved from current location to the reaction disc mechanism side The time expended needed for the reagent adding station of setting；
The third operating time is that the third reaction vessel moves to needed for the reagent adding station from current location The time of consuming.
In one embodiment, the delay execute by first reaction vessel postpone punched disc mechanism be transferred to it is described React the operation of disc mechanism, comprising:
By first reaction vessel postpone punched disc mechanism be transferred to it is described reaction disc mechanism operation, postpone one or more A buffer disc period of motion, until each object run of first reaction vessel and second reaction vessel and described the Each object run of three reaction vessels is non-interference.
In one embodiment, the method also includes following steps:
If the quantity of the delayed buffer disc period of motion is greater than or equal to preset threshold, sample charging mechanism pause is controlled It spits sample operation or controls the sample charging mechanism delay and inhale sample operation.
In one embodiment, the value range of the preset threshold is 20~40, each buffer disc movement week The duration of phase is 3 seconds.
In one embodiment, the method also includes following steps:
When first reaction vessel and each second reaction vessel and each third reaction vessel mutually not When interference, then controls sample and grab cup mechanism first reaction vessel is transferred to the reaction tray machine from the buffering disc mechanism Structure.
Meanwhile the present invention also provides a kind of control systems of chemiluminescence detector, comprising:
Module is obtained, for obtaining the test item information of each reaction vessel on chemiluminescence detector, wherein institute Stating test item information includes the multiple object runs executed needed for the reaction vessel and each object run institute of completion The operating time needed；
First judgment module judges buffer disc machine for the test item information according to each reaction vessel respectively Whether the first reaction vessel on structure will execute together with each second reaction vessel reacted on disc mechanism within the same period One object run；
Second judgment module judges buffer disc machine for the test item information according to each reaction vessel respectively It is same whether the first reaction vessel on structure will execute with each third reaction vessel on cleaning device within the same period Object run；
Control module, in first reaction vessel and more than one second reaction vessel and/or one Above third reaction vessel, will execute same object run within the same period, then will postpone to execute described first Reaction vessel is transferred to the operation of the reaction disc mechanism from the buffering disc mechanism.
In addition, the present invention also provides a kind of control system of chemiluminescence detector, including processor and for storing The memory of computer program, the processor execute side as described in any one of the above embodiments when executing the computer program Method.
Finally, the present invention also provides a kind of chemiluminescence detector, including above-mentioned control system.
The solution have the advantages that:
Control method, system and the chemiluminescence detector of chemiluminescence detector of the invention, can be by each anti- Answer the test item information of container, respectively the first reaction vessel on judgement buffering disc mechanism with react on disc mechanism each the Whether two reaction vessels will execute same object run within the same period, and first respectively on judgement buffering disc mechanism is anti- Answer whether each third reaction vessel on container and cleaning device will execute same object run within the same period；If sentencing Fixed first reaction vessel and more than one second reaction vessel and/or more than one third reaction vessel are in the same period When the same object run of interior execution, then illustrate that first reaction vessel and the second reaction vessel and/or third reaction vessel exist Conflict in timing, the conflict in the timing will lead to resource transfer conflict when completing same object run, at this point it is possible to logical Cross delay execute by the first reaction vessel postpone punched disc mechanism be transferred to reaction disc mechanism operation, to solve in detection process Resource transfer conflict, and can be by there is no in timing with the second reaction vessel and/or third reaction vessel on buffering disc mechanism Other first reaction vessels of conflict are transferred on reaction disc mechanism, to improve the detection efficiency of the chemiluminescence detector.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the chemiluminescence detector of an embodiment；
Fig. 2 is the structural schematic diagram that one embodiment of disc mechanism is buffered in Fig. 1；
Fig. 3 is the structural schematic diagram that one embodiment of disc mechanism is reacted in Fig. 1；
Fig. 4 is the flow chart of the control method of the chemiluminescence detector of an embodiment；
Fig. 5 is the flow chart of the control method of the chemiluminescence detector of an embodiment；
Fig. 6 is the flow chart of the control method of the chemiluminescence detector of an embodiment；
Fig. 7 is the flow chart of the control method of the chemiluminescence detector of an embodiment；
Fig. 8 is the flow chart of the control method of the chemiluminescence detector of an embodiment；
Fig. 9 is the flow chart of the control method of the chemiluminescence detector of an embodiment；
Figure 10 is the system block diagram of the control system of the chemiluminescence detector of an embodiment.
Specific embodiment
In order to keep technical solution of the present invention clearer, below in conjunction with attached drawing, to chemiluminescence detector of the invention Control method, system and chemiluminescence detector be described in further detail.It should be appreciated that specific reality described herein Example is applied only to explain that the present invention is not intended to limit the present invention.It should be noted that in the absence of conflict, in the application Embodiment and embodiment in feature can be combined with each other.
It should be noted that being herein component institute serialization number itself, such as " first ", " second " etc., it is only used for distinguishing Described object does not have any sequence or art-recognized meanings.And " connection ", " connection " described in the application, unless otherwise instructed, It include directly or indirectly connecting (connection).In the description of the present invention, it is to be understood that, term " on ", "lower", " preceding ", The side of the instructions such as " rear ", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outside", " clockwise ", " counterclockwise " Position or positional relationship are to be based on the orientation or positional relationship shown in the drawings, and are merely for convenience of description of the present invention and simplification of the description, Rather than the device or element of indication or suggestion meaning must have a particular orientation, be constructed and operated in a specific orientation, because This is not considered as limiting the invention.
In the present invention unless specifically defined or limited otherwise, fisrt feature in the second feature " on " or " down " can be with It is that the first and second features directly contact or the first and second features pass through intermediary mediate contact.Moreover, fisrt feature exists Second feature " on ", " top " and " above " but fisrt feature be directly above or diagonally above the second feature, or be merely representative of First feature horizontal height is higher than second feature.Fisrt feature can be under the second feature " below ", " below " and " below " One feature is directly under or diagonally below the second feature, or is merely representative of first feature horizontal height less than second feature.
As shown in Figure 1, the chemiluminescence detector of one embodiment of the invention can be handled sample, and to processing after Sample carry out analysis detection, obtain corresponding testing result, satisfy the use demand.It should be noted that sample to be measured Specific type is unrestricted, and in some embodiments, sample to be measured includes solid sample or liquid sample.Further, Liquid sample includes but is not limited to blood sample.The chemiluminescence detector of the present embodiment is wanted according to the processing timing of different samples It asks and carries out reagent adding, mixing and incubate operation etc., can satisfy the process demand of different samples, sample is filled with reagent Divide reaction, improves the accuracy of pattern detection result.
Specifically, as depicted in figs. 1 and 2, chemiluminescence detector may include pedestal 10, reagent storage means 11, divide Dispensing device 12, reaction unit 13, cleaning device 14, measuring device 15 and cup device 16 is grabbed, reagent storage means 11, dispensing dress It sets 12, reaction unit 13, cleaning device 14, measuring device 15 and grabs cup device 16 etc. and be arranged on pedestal 10.Wherein, instead Answer device 13 for carrying reaction vessel 20, and to realize the operations such as sample-adding sheet, reagent adding, mixing and incubation.Optionally, instead Container 20 is answered to refer to the consumptive material for carrying and being able to carry out pattern detection analysis, such as reaction cup, test tube, sample slide, sample tube Deng.The marginal position of pedestal 10 is arranged in reagent storage means 11, and reagent storage means 11 are placed in the side of reaction unit 13, For storing reagent.The side of reaction unit 13 is arranged in dispenser 12, and dispenser 12 can be held on reaction unit 13 Sample and/or reagent are added in the reaction vessel of load.The side of reaction unit 13, cleaning device is arranged in cleaning device 14 14 for removing the impurity in the reaction vessel 20 after incubating, and measuring device 15 is used to carry out the determinand in reaction vessel 20 Detection.Cup device 16 is grabbed for realizing reaction vessel 20 between reaction unit 13, cleaning device 14 and measuring device 15 Transfer improves operating efficiency to realize the detection that automatically analyzes of sample.
Optionally, reaction unit 13 includes buffering disc mechanism 131 and reaction disc mechanism, buffers disc mechanism 131 and reaction tray Mechanism independent operating.As shown in Fig. 2, buffering disc mechanism 131 includes rotatable buffering carrier 1311 and carries with buffering The buffered-display driver structure 1313 that disk 1311 is sequentially connected, buffered-display driver structure 1313 can drive buffering carrier 1311 to rotate. Further, buffering carrier 1311 is in the form of annular discs, certainly, in other embodiments of the invention, buffers carrier 1311 Can also oval, quadrangle or other can carry the shape of reaction vessel 20.Optionally, it buffers and is set on carrier 1311 Set multiple loading hole 13111 for placing response container 20, multiple loading hole 13111 on buffering carrier 1311 radially Direction is arranged in rows, enables to the ordered arrangement on buffering carrier 1311 of loading hole 13111 in this way.Further, more After a loading hole 13111 is arranged in column, the loading hole 13111 of multiple equal radiuses along circumferential direction on the rounded distribution of line, And the loading hole 13111 of multiple circular distributions is arranged around the center of circle of buffering carrier 1311 in concentric circles, so that multiple loadings Hole 13111 radially distributes relative to the center of circle of buffering carrier 1311.
Optionally, as shown in Figure 1, the chemiluminescence detector further includes the reaction vessel that 10 marginal position of pedestal is arranged in Conveying device 17, reaction vessel conveying device 17 are used for transmission new reaction vessel.Grabbing cup device 16 may include that new cup grabs cup Mechanism 161 and sample grab cup mechanism 162, wherein new cup is grabbed cup mechanism 161 and is arranged in 17 side of reaction vessel conveying device, newly Cup is grabbed cup mechanism 161 and can be transferred to the new reaction vessel in reaction vessel conveying device 17 on buffering disc mechanism 131.Sample Originally it grabs cup mechanism 162 and corresponds to and react outer disc mechanism 132 and the buffering setting of disc mechanism 131, be used for reaction vessel 20 is outer from reaction Disc mechanism 132 be transferred to buffering disc mechanism 131 on, or by reaction vessel 20 postpone punched disc mechanism 131 be transferred to reaction external disk machine On structure 132.Optionally, dispenser 12 may include sample charging mechanism 121 and the setting that buffering 131 side of disc mechanism is arranged in Pipetting device 122 in reagent storage means side.
Correspondingly, the side for buffering disc mechanism 131 is provided with new cup and carries position, transfer cup position and sample-adding position.In this way, working as When buffered-display driver structure 1313 drives an idle loading hole on buffering carrier 1311 to be directed at new cup load position, new cup is grabbed Cup mechanism 161 can place new reaction vessel on buffering disc mechanism 131.When buffered-display driver structure 1313 drives buffering carrying When one on the disk 1311 loading hole alignment for having loaded reaction vessel is loaded position, sample charging mechanism 121 can be placed in sample-adding to this Sample is spat in the reaction vessel of position, so as to carry out new cup loading operation and sample-adding operation on buffering disc mechanism 131.Work as buffering When driving structure 1313 drives one on buffering carrier 1311 loading hole for having loaded reaction vessel is corresponding to shift cup position, sample Originally grabbing cup mechanism 162 can be transferred to the reaction vessel buffered on disc mechanism on the outer disc mechanism of reaction.Certainly, sample grabs a glass machine Structure 162 can also will react the reaction vessel that the transfer cup position is on outer disc mechanism, be transferred on buffering disc mechanism 131.
As shown in figure 3, reaction disc mechanism may include in independently operated reaction disc mechanism 133 with react outer disc mechanism 132, it reacts outer disc mechanism 132 and is sheathed on the outside for reacting interior disc mechanism 133.Further, reacting outer disc mechanism 132 can be with It is coaxially disposed with interior disc mechanism 133 is reacted.Reaction vessel 20 can be accommodated and execute reagent adding and mix by reacting outer disc mechanism 132 Operation, reaction vessel 20 can be accommodated and execute incubation operation by reacting interior disc mechanism 133.As shown in Figure 1, buffering disc mechanism 131 The side for reacting outer disc mechanism 132 is set, and buffers disc mechanism 131 and is placed in the outer disc mechanism 132 of reaction and reaction vessel conveying Between device 17.
Optionally, the side for reacting outer disc mechanism 132 is provided with multiple reaction stations, including adds a glass station, reagent adding work Position, mixing station incubate to take glass station and clean and put a glass station, and cup station, cleaning is added to put a glass station, reagent adding station, mix Even station and incubation take glass station not change with the rotation for reacting outer disc mechanism 132, wherein add glass station and The transfer cup position of buffering 131 side of disc mechanism setting is correspondingly arranged, and further, adds glass station and buffering 131 side of disc mechanism The transfer cup position of setting can be same position.Correspondingly, as shown in figure 3, the outer disc mechanism 132 of reaction includes reaction external disk carrying Disk 1321 reacts and is provided with multiple receiving positions 13211 on external disk carrier 1321, and multiple receiving positions 13211 are along reaction external disk machine The circumferential setting of structure 132.Reacting external disk driving structure being capable of the reaction vessel of the drive of drive response external disk carrier 1321 thereon 20 turn to corresponding reaction station, and execute corresponding operation in reaction station.For example, when reacting the one of outer disc mechanism 132 When the alignment of a receiving position 13211 plus cup station, sample grab cup mechanism 162 can to by reaction vessel outside reaction disc mechanism 132 It is transferred to buffering disc mechanism 131, or reaction vessel punched disc mechanism 131 of postponing is transferred to the outer disc mechanism 132 of reaction.When reaction is outer When one receiving position of disc mechanism 132 is directed at reagent adding station, then pipetting device 122 can hold to the reaction for being placed in reagent adding position Reagent is added in device.When glass station is put in the receivings position alignment cleaning for reacting outer disc mechanism 132, then may be implemented to react appearance Transfer of the device between cleaning device 14 and reaction disc mechanism, the mode of operation of other each stations is similar, herein no longer It enumerates.
Optionally, grabbing cup device 16 further includes incubating grab cup mechanism 163, clean to grab cup mechanism 164 and measure and grab a glass machine Structure 165, wherein the corresponding cleaning device 14 of cup mechanism 164 and reaction disc mechanism setting are grabbed in cleaning, are used for reaction vessel 20 anti- It answers and is shifted between disc mechanism and cleaning device 14.Specifically, when cup is put in the receiving position alignment cleaning for reacting outer disc mechanism 132 When station, then cleaning grab cup mechanism 164 can will react in incubate the reaction vessel of completion on disc mechanism 133 and be transferred to cleaning dress Set 14；Alternatively, when cleaning complete reaction vessel need carry out again reagent adding operate when, cleaning grab cup mechanism 164 can will Reaction vessel on cleaning device 14, which is transferred to, to react on the corresponding receiving position for putting glass station on outer disc mechanism 131 with cleaning. Incubation is grabbed the corresponding outer disc mechanism 132 of reaction of cup mechanism 163 and is arranged with interior disc mechanism 133 is reacted, and exists for realizing reaction vessel 20 React outer disc mechanism 132 with react the transfer between interior disc mechanism 133.Measurement is grabbed the corresponding cleaning device 14 of cup mechanism 165 and is surveyed It measures device 15 to be arranged, for the reaction vessel 20 after cleaning in cleaning device 14 to be transferred in measuring device 15.
It should be noted that new, cup grabs cup mechanism 161, sample grabs cup mechanism 162, incubates and grabs cup mechanism 163, cleans and grab cup Cup mechanism 165 is grabbed by mechanism 164, measurement can be anti-using grabbing a glass driving assembly, grabbing glass control assembly and grabbing the realizations such as glass arm component Answer the crawl and transfer of container 20.It is understood that general control system such as controller can be used by grabbing glass control assembly Etc., grabbing glass driving assembly can be using driving motor mate gear transmission component, V belt translation component or chain kit etc. Realize the motion control for grabbing glass arm component, so as to grab a glass movement for arm component carry out level and vertical direction, a glass arm group is grabbed in guarantee Part moves in place and grabs transfer reaction container 20.Moreover, grabbing the end of glass arm component has handgrip, is grabbed and reacted by handgrip Container 20.
Optionally, reagent storage means 11 include two reagent storing mechanisms 111 being set side by side, pipetting device 122 Quantity may be two, and two pipetting devices 122 are correspondingly arranged with two reagent storing mechanisms 111.Further, reagent adding The quantity of station is also two, respectively corresponds two reagent storing mechanisms 111 and two pipetting devices 122 are arranged, improve examination The efficiency of agent transfer, then improves the speed of service of instrument.Further, two reagent adding stations can be respectively labeled as One reagent adding station and the second reagent adding station add a glass station, cleaning to put a glass station, the first reagent adding station, the second reagent adding Station mixes station and incubates the circumferential sequence for taking glass station edge to react outer disc mechanism and arranges.
Optionally, which can also include the evenly mixing device being arranged on pedestal 10 and sample conveying Device 19 etc..Wherein, evenly mixing device is set on the outer disc mechanism 132 of reaction, and the corresponding station that mixes is arranged, the evenly mixing device For carrying out mixing operation to the solution in reaction vessel.The marginal position of pedestal 10 is arranged in sample conveying device 19, is used for Sample is delivered to sample position, sample position is located at the side of buffering disc mechanism 131 and corresponding sample charging mechanism 121 is arranged, and adds Model machine structure 121 is drawn sample in sample position and is transferred in the reaction vessel of buffering disc mechanism 131.
Optionally, which further includes control system, is reacted on buffering disc mechanism 131 for automatically controlling The scheduling of container.Specifically, control system can control new cup grab cup mechanism 161 loaded on buffering disc mechanism 131 it is new anti- Container is answered, sample charging mechanism 121 can add sample in the reaction vessel on buffering disc mechanism 131.Later, control system can be with It controls the reaction vessel for having added sample to be transferred to progress reagent adding operation on reaction disc mechanism and incubate operation, and will incubate Reaction vessel after the completion, which is transferred on cleaning device 14, carries out cleaning operation.After completing the cleaning operation of the reaction vessel, It is enterprising that the reaction vessel after the completion of the cleaning can be transferred to measuring device 15 according to the test item information of the reaction vessel Row detection operation carries out secondary reagent adding alternatively, the reaction vessel after the completion of the cleaning is transferred on the outer disc mechanism 132 of reaction Operation etc..Since the test item of each reaction vessel is different, accordingly, it is possible to which there are more than two reaction vessels same Moment needs to be implemented same operation, for example, more than two reaction vessels are needed in synchronization using same pipetting device 122 Cup mechanism 164 need to be grabbed from reaction inner disc using cleaning in synchronization by carrying out reagent adding operation or more than two reaction vessels Mechanism 133 is transferred to cleaning device 14, i.e., there are the conflicts of resource transfer for more than two reaction vessels.
For the conflict for solving above-mentioned resource transfer, first reaction vessel of the control system on control buffering disc mechanism 131 It is transferred to before reaction disc mechanism, first determines whether first reaction vessel holds with multiple second reactions reacted on disc mechanism With the presence or absence of the interference in timing between device and/or multiple third reaction vessels of cleaning device 14, i.e., buffer disc is judged respectively The first reaction vessel in mechanism 131 and each second reaction vessel for reacting on disc mechanism and/or each on cleaning device 14 Whether a third reaction vessel will execute same object run within the same period.If control system determines the first reaction vessel Same target is executed within the same period with more than one second reaction vessel and/or more than one third reaction vessel When operation, then illustrate that first reaction vessel, there are conflicting in timing, is somebody's turn to do with the second reaction vessel and/or third reaction vessel Conflict in timing will lead to resource transfer conflict when completing same object run, at this point it is possible to be executed by delay by the One reaction vessel postpone punched disc mechanism 131 be transferred to reaction disc mechanism operation, with solve the resource transfer in detection process punching Prominent, at this point it is possible to will buffer on disc mechanism, there is no first to conflict to react with the second reaction vessel and/or third reaction vessel Container is preferentially transferred on reaction disc mechanism, so as to improve the detection efficiency of the chemiluminescence detector.Further, when Delay execute by the first reaction vessel postpone punched disc mechanism be transferred to reaction disc mechanism operation when, sample charging mechanism can also be controlled Sample operation is inhaled in 121 pause sample-adding operations or the control delay of sample charging mechanism 121.
As shown in figure 4, the control method for the chemiluminescence detector that the present invention one is implemented, is examined for above-mentioned chemiluminescence It surveys in instrument, for realizing other dresses in the scheduling controlling and chemiluminescence detector of reaction vessel on chemiluminescence detector The automatic control set.Specifically, the above method includes the following steps:
S100, the test item information for obtaining each reaction vessel on chemiluminescence detector, wherein each reaction appearance Operation needed for the test item information of device includes the multiple object runs executed needed for reaction vessel, completes each object run Time and the current test operation of the reaction vessel etc. can get the reaction according to the current test operation of the reaction vessel and holds The information such as the current location of device.For example, the test item information of each reaction vessel may include that current reaction vessel completion is whole The multiple object runs passed through needed for a detection, such as sample-adding operation, reagent adding operation mix operation, incubate operation, cleaning transfer Operation, cleaning operation and detection operation etc..The test item information of each reaction vessel can also include completing each target behaviour The operating time expended needed for making, and the corresponding position of next object run is moved to from the corresponding position of current test operation Required time etc..
Further, when reaction vessel, which is placed on buffering disc mechanism 131, carries out sample-adding operation, control system can basis The sample identification information for the current sample that sample charging mechanism 122 is drawn, obtains the test item information of current sample, for example, control System can scan the sample mark of the current sample of the acquisitions such as bar code or RFID label tag on the containers such as the test tube for holding current sample Know information.When the current sample that sample charging mechanism 122 is drawn is added in the reaction vessel on buffer disc, the current sample Test item information be the reaction vessel test item information.Certainly, control system can also be according to the mark of reaction vessel The test item information of number equal information acquisitions reaction vessel.For example, being in vacant shape on the selected buffering disc mechanism 131 of control system The reaction vessel of state carries out taking reagent operation, such as carries out that dilution or calibration solution is taken to operate, the mark of the selected reaction vessel It number can be No. 1, thus, control system can be obtained according to the label of No. 1 reaction vessel and the relevant operation needed to be implemented The test item information of the reaction vessel.
S200, the test item information according to each reaction vessel, respectively the first reaction on judgement buffering disc mechanism 131 Whether container will execute same object run with each second reaction vessel reacted on disc mechanism within the same period；Its In, which can be the operating time expended needed for completing the object run.Specifically, which can To be to need to postpone the reaction vessel being transferred on punched disc mechanism 131 on reaction disc mechanism, as first reaction vessel can be The reaction vessel or first reaction vessel that sample-adding operation is completed, which can be, needs the reaction cup in blank state, should The reaction vessel of blank state out of reagent storage means for obtaining destination agent.Certainly, the first reaction vessel can also be Other can be transferred to the reaction vessel reacted on outer disc mechanism on buffering disc mechanism 131.
S300, the test item information according to each reaction vessel, respectively the first reaction on judgement buffering disc mechanism 131 Whether each third reaction vessel on container and cleaning device 14 will execute same object run within the same period；Its In, which can be the operating time expended needed for completing the object run.
If the first reaction vessel and more than one second reaction vessel and/or more than one third reaction vessel will be Same object run is executed in the same period, then illustrates that the first reaction vessel reacts appearance with the second reaction vessel and/or third There are timing interference between the object run of device, which interferes the conflict that will lead to resource transfer, can execute step at this time S400, delay, which is executed, is transferred to the transfer operation of reaction disc mechanism for the first reaction vessel punched disc mechanism 131 of postponing, to avoid the The timing conflict problem of one reaction vessel and the second reaction vessel and/or third reaction vessel.Further, when delay execute general First reaction vessel postpone punched disc mechanism 131 be transferred to reaction disc mechanism transfer operation when, sample charging mechanism can be controlled simultaneously Sample operation is spat in 122 pauses, or control delay a period of time of sample charging mechanism 122 carries out inhaling sample operation again.It in this way can be to avoid first Sample exposure time is too long in reaction vessel, leads to problems such as testing result inaccurate.Further, when delay execution should First reaction vessel postpone punched disc mechanism 131 be transferred to reaction disc mechanism transfer operation when, can continue at this time judgement buffering Whether there are rushing in timing with the second reaction vessel and/or third reaction vessel for other first reaction vessels on disc mechanism It is prominent, it, will if there is the reaction vessel not conflicted with the second reaction vessel and/or third reaction vessel on buffering disc mechanism The reaction vessel there is no conflict, which is preferentially postponed, to be transferred on punched disc mechanism on reaction disc mechanism.
Further, when the first reaction vessel and each second reaction vessel and each third reaction vessel are non-interference When, i.e., the reagent adding operation, cleaning transfer operation, detection operation etc. of first reaction vessel will not be with each second instead at this time The conflict in container or each third reaction vessel generation timing sequence is answered, step S500 can be executed at this time, control sample grabs a glass machine First reaction vessel punched disc mechanism 131 of postponing is transferred to reaction disc mechanism by structure 162, so as to according to the first reaction vessel Test item carries out reagent adding operation, incubation operation, cleaning operation and detection operation etc. to first reaction vessel.
Further, as shown in figure 5, the above method specifically comprises the following steps:
S210, the test item information according to the first reaction vessel obtain the first reaction vessel and move to from current location With the first operating time of current goal operation corresponding position；Specifically, the current location of first reaction vessel can be slow Sample-adding position or transfer cup position of 131 side of punched disc mechanism etc., the current object run can be reagent adding operation, incubate behaviour Make, clean transfer operation or detection operation etc..First operating time can be the first reaction on buffering disc mechanism 131 and hold Device is moved to from current location operate corresponding reagent adding station with reagent adding needed for the time, which can also be with It is to buffer the first reaction vessel on disc mechanism 131 to move to time and the incubative time reacted on interior disc mechanism from current location Summation, i.e., first operating time can be first reaction vessel complete incubate operation needed for time.
S220, respectively according to the test item information of each second reaction vessel, obtain each second reaction vessel from working as Front position moves to the second operating time of current goal operation corresponding position；Specifically, the present bit of second reaction vessel Set can be reagent adding station, mix station, incubate take cup position, incubation position (incubation position in reaction on disc mechanism 133 It can be the position in the incubation hole being arranged on disc mechanism 133 in reacting, i.e. second reaction vessel is placed on disc mechanism in reaction In 133 which incubation hole) etc..Second operating time can be the second reaction vessel and incubate from current location to completion Time needed for operation.
S230, respectively according to the test item information of third reaction vessel, obtain each third reaction vessel from present bit Set the third operating time moved to current goal operation corresponding position；Specifically, the current location of the third reaction vessel It can be cleaning device 14, which can be third reaction vessel and move to and reagent adding behaviour from cleaning device 14 Time needed for making corresponding reagent adding station.
S240, the second operating time corresponding with more than one second reaction vessel the first operating time is judged respectively Within a preset time whether time interval；Judging the time interval of the first operating time and each second operating time respectively is It is no to be less than or equal to the preset time, wherein the preset time, which can be, completes the current goal operation required operating time.
S250, the third operating time corresponding with more than one third reaction vessel the first operating time is judged respectively Time interval is within a preset time；Judge whether the time interval of the first operating time and each third operating time are small respectively In or equal to the preset time, wherein the preset time is the operating time needed for completing current goal operation.
If the time interval of the second operating time corresponding with more than one second reaction vessel the first operating time exists In preset time and/or the time of third operating time corresponding with more than one third reaction vessel the first operating time Interval within a preset time, thens follow the steps S260, determines that the first reaction vessel reacts appearance with the second reaction vessel and/or third Device will execute same object run within the same period.
If the time interval of the second operating time corresponding with any one second reaction vessel the first operating time is big Between the time of preset time and/or third operating time corresponding with any one third reaction vessel the first operating time Every being all larger than preset time, then determine that the first reaction vessel with the second reaction vessel and/or third reaction vessel is not in dry Phenomenon is related to, at this point it is possible to execute step S270, it can determine that the first reaction vessel reacts appearance with the second reaction vessel and third Each object run of device is not interfered, can execute step S500 later, and control sample grabs cup mechanism 162 and holds the first reaction Device punched disc mechanism 131 of postponing is transferred to reaction disc mechanism, so as to according to the test item of the first reaction vessel to this first Reaction vessel carries out reagent adding operation, incubation operation, cleaning operation and detection operation etc..
Further, which can be 0, even the first operating time and more than one second reaction vessel Corresponding second operating time is equal and/or the first operating time third corresponding with more than one third reaction vessel is grasped It is equal to make the time, then illustrates that the first reaction vessel needs to hold in synchronization with the second reaction vessel and/or third reaction vessel The same object run of row, determines that the first reaction vessel and the second reaction vessel and/or third reaction vessel will be in same a period of time at this time Between same object run is executed in section.
In one embodiment, incubate the second anti-of operation there may be multiple on disc mechanism 133 in reacting Container is answered, according to the corresponding test item information of each second reaction vessel, the incubation of each second reaction vessel can be obtained The information such as total time, incubative time and remaining incubative time.Since the incubation total time of each second reaction vessel may Difference, therefore when reacting the second reaction vessel completion incubation operation on disc mechanism, needing to grab cup mechanism 164 by cleaning will The second reaction vessel that incubation operation is completed, which is transferred on cleaning device 14, carries out cleaning operation.Due to the chemiluminescence detection It is only provided only with a cleaning on instrument and grabs cup mechanism 164, therefore, when incubation operation is completed there are more than two in synchronization The second reaction vessel need to be transferred on cleaning device 14 carry out cleaning operation when, it will occur cleaning grab cup mechanism 164 Resource transfer conflict.
In the present embodiment, if current goal operation can be transferred to cleaning dress for the reaction vessel for incubating operation will be completed When setting 14 cleaning transfer operation, above-mentioned preset time can be the first preset time, which can be clear It washes and grabs the time that the second reaction vessel on reaction disc mechanism is transferred to required consuming on cleaning device 14 by cup mechanism 164.This When, if the time interval of first operating time and more than one second reaction vessel corresponding second operating time are less than Or be equal to the first preset time, then determine that the first reaction vessel and the second reaction vessel will execute cleaning within the same period and turn Move operation.Wherein, the first operating time was the first reaction vessel from current location to the time for completing to expend needed for incubating operation, I.e. first operating time is that the first reaction vessel moves to the time for reacting interior disc mechanism and incubative time from current location Summation.Second operating time was that the second reaction vessel is completed to expend needed for incubating operation from current location to the second reaction vessel Time, i.e., second operating time be placed in react in the second reaction vessel on disc mechanism remaining incubative time, or set The time in reaction on disc mechanism and the summation of incubative time are transferred in reacting the second reaction vessel on outer disc mechanism.Tool Body, as shown in fig. 6, when the object run of each reaction vessel is cleaning transfer operation, above-mentioned steps S200 further include:
S211, the test item information according to the first reaction vessel obtain the first reaction vessel from current location to completion Incubate the first operating time expended needed for operation；Specifically, which can be the first reaction vessel from buffering The time expended needed for disc mechanism 133 in reacting, and the incubation in reacting on disc mechanism 133 are moved on disc mechanism 131 Time.Further, first reaction vessel can be predicted by first operating time and current time to complete to incubate behaviour At the time of work.
S221, the test item information according to the second reaction vessel obtain the second reaction vessel from current location to completion Incubate the second operating time expended needed for operation；Specifically, which can be in reaction on disc mechanism 133 the The second reaction vessel moves to instead from current location on the remaining incubative time of two reaction vessels, or the outer disc mechanism 132 of reaction Answer the summation of the time and incubative time expended needed for interior disc mechanism 133.Further, by second operating time and At the time of current time can predict second reaction vessel completion incubation operation.
S241, judged between the first operating time and the time of each second reaction vessel corresponding second operating time respectively Every whether in the first preset time；It is and each at the time of it is possible to further judge that the first reaction vessel is completed to incubate operation Second reaction vessel completes to incubate time interval at the time of operation whether in the first preset time.Wherein, first it is default when Between for cleaning grab cup mechanism 164 complete by reaction vessel from reaction disc mechanism be transferred to cleaning device 14 needed for consuming operation when Between, for example, first preset time can be 3 seconds.
If the time interval of the first operating time and more than one second reaction vessel corresponding second operating time exist In first preset time, it is default that the time interval between even the first operating time and the second operating time is less than or equal to first Time thens follow the steps S261, determines that the first reaction vessel and the second reaction vessel will execute cleaning within the same period and turn Move operation.For example, if the time interval of the first operating time and the second operating time be 0.1 second~2.9 seconds when, it may be considered that The time interval of first operating time and the second operating time are in the first preset time, at this time it is considered that the first reaction is held Device will can postpone to execute to be transferred to the first reaction vessel and react external disk machine with the second reaction vessel there are the conflict in timing Operation on structure 132.Further, if the first operating time and the second operating time are equal, i.e. the first reaction vessel and second Reaction vessel needs then to hold when synchronization is transferred to progress cleaning operation on cleaning device 14 from the interior disc mechanism 133 of reaction Row step S261 determines that the first reaction vessel and the second reaction vessel will execute cleaning transfer operation within the same period.
Further, when between the time of the second operating time corresponding with each second reaction vessel the first operating time Every not within a preset time, i.e. between the time of the second operating time corresponding with each second reaction vessel the first operating time Every being all larger than the first preset time, S281 is thened follow the steps, do not determine the first reaction vessel and each second reaction vessel mutually not Interference.
In one embodiment, if current goal operation can be slow for the reaction vessel reacted on outer disc mechanism to be transferred to When the sample transfer operation of punched disc mechanism, above-mentioned preset time can be the second preset time, which can be with Cup mechanism 162 is grabbed for sample, and the second reaction vessel reacted on outer disc mechanism is transferred to required consuming on buffering disc mechanism 131 Time.At this point, if between the first operating time and the time of more than one second reaction vessel corresponding second operating time Every being less than or equal to the second preset time, then determine that the first reaction vessel will be executed with the second reaction vessel within the same period Sample transfer operation.Wherein, which moves to buffering disc mechanism side from current location for the first reaction vessel Transfer cup position needed for expend time.Second operating time moved to reaction external disk machine from current location for the second reaction vessel Structure side plus the required consuming of cup station time.Specifically, as shown in fig. 7, when the object run of each reaction vessel is sample When this transfer operation, above-mentioned steps S200 further include:
S212, the test item information according to the first reaction vessel obtain the first reaction vessel and move to from current location First operating time needed for buffering the transfer cup position of disc mechanism side.
S222, respectively according to the test item information of each second reaction vessel, obtain each second reaction vessel from working as Front position moves to outer 132 side of disc mechanism of reaction plus the required consuming of cup station the second operating time.
S242, judged between the first operating time and the time of each second reaction vessel corresponding second operating time respectively Every whether in the second preset time；Wherein, the second preset time is that sample is grabbed cup mechanism 162 and completed reaction vessel from reaction Outer disc mechanism 132 is transferred to the operating time expended needed for buffering disc mechanism 131, for example, second preset time can be 3 Second.
If the time interval of the first operating time and more than one second reaction vessel corresponding second operating time exist In second preset time, it is default that the time interval between even the first operating time and the second operating time is less than or equal to second Time thens follow the steps S262, determines that the first reaction vessel and the second reaction vessel will execute sample within the same period and turn Move operation.For example, if the time interval of the first operating time and the second operating time be 0.1 second~2.9 seconds when, it may be considered that The time interval of first operating time and the second operating time are in the second preset time, at this time it is considered that the first reaction is held Device will can postpone to execute to be transferred to the first reaction vessel and react external disk machine with the second reaction vessel there are the conflict in timing Operation on structure 132.Further, if the first operating time and the second operating time are equal, i.e. the first reaction vessel and second Reaction vessel needs to then follow the steps S262 when synchronization grabs cup mechanism 162 using sample and carries out position transfer, determines the One reaction vessel and the second reaction vessel will execute sample transfer operation within the same period.
Optionally, if it is determined that the first reaction vessel and the second reaction vessel will execute sample transfer behaviour within the same period Make, at this point, can postpone a buffer disc period of motion is transferred to reaction external disk for the first reaction vessel buffered on disc mechanism again In mechanism.I.e. if it is determined that when the first reaction vessel and the second reaction vessel will execute sample transfer operation within the same period, Control sample is grabbed cup mechanism and is filled the free time that the second reaction vessel on outer disc mechanism is transferred on buffering disc mechanism is reacted first It carries in hole, later, control buffering disc mechanism drives the first reaction vessel to turn to transfer cup position, so that sample grabs cup mechanism energy It is enough that first reaction vessel is transferred to the outer disc mechanism of reaction from buffering external disk mechanism.Wherein, the buffer disc period of motion refers to A loading hole 13111 on buffering disc mechanism 131 moves to total duration spent by target movement position from current location, should Target movement position can carry position, sample-adding position or transfer cup position for new cup.For example, the buffer disc period of motion can be 3 seconds.
Further, when between the time of the second operating time corresponding with each second reaction vessel the first operating time Every not within a preset time, i.e. between the time of the second operating time corresponding with each second reaction vessel the first operating time Every being all larger than the second preset time, S281 is thened follow the steps, do not determine the first reaction vessel and each second reaction vessel mutually not Interference.
In one embodiment, incubate the second anti-of operation there may be multiple on disc mechanism 133 in reacting Container is answered, according to the corresponding test item information of each second reaction vessel, the incubation of each second reaction vessel can be obtained The information such as total time, incubative time and remaining incubative time.Since the incubation total time of each second reaction vessel may Difference, therefore when reacting the second reaction vessel completion incubation operation on disc mechanism, it may be necessary to cup mechanism is grabbed by incubating The second reaction vessel for incubating and operating will be completed to be transferred on the outer disc mechanism of reaction, to react complete to incubate operation second Container continues reagent adding operation.The second reaction vessel that the completion incubates operation may be anti-with first on buffering disc mechanism It answers container while reaching same reagent adding station, and need to carry out reagent adding operation using the same reagent adding mechanism, thus will It will appear the resource transfer conflict of reagent adding mechanism.
Therefore, current goal operation is that reagent adding operates, and above-mentioned preset time can also include third preset time, In, third preset time is the operating time needed for completing reagent adding operation.At this point, if the first operating time and more than one Time interval between second reaction vessel corresponding second operating time then determines that the first reaction is held in third preset time Device and the second reaction vessel will execute reagent adding operation within the same period.Wherein, the first operating time was that the first reaction is held The device current location postponed on punched disc mechanism 131 of movement expended needed for the reagent adding station to the setting of reaction disc mechanism side when Between；Second operating time was that time of consuming needed for the second reaction vessel moves to reagent adding station from current location, (it can be with The time that the position of the incubation on interior disc mechanism is reacted comprising moving to from current location incubates total time or remaining incubative time, And complete the time for moving to reagent adding station after incubation operates from incubation position).As shown in figure 8, the above method further include:
S213, the test item information according to the first reaction vessel, obtaining the first reaction vessel postpones on punched disc mechanism 131 Move to the first operating time expended needed for the reagent adding station of reaction disc mechanism side setting；Specifically, when this is first anti- When to answer container be reaction vessel in blank state, which can be the first reaction vessel and postpones punched disc mechanism The time reacted and expended on outer disc mechanism 132 is transferred on 131, and outer disc mechanism 132 is corresponding plus cup station is transported from reacting Move the summation for the time expended to reagent adding station.When first reaction vessel is the reaction vessel for being contained with sample, this One operating time can also include the time that sample-adding operation expends.Further, pass through first operating time and current time At the time of first reaction vessel can be predicted moving to reagent adding station.
S223, the test item information according to the second reaction vessel obtain the second reaction vessel and move to reagent adding station Second operating time of required consuming；It specifically, can be respectively according to reaction disc mechanism (including the outer disc mechanism of reaction and in reacting Disc mechanism) on each second reaction vessel test item information, obtain respectively each second reaction vessel from reaction disc mechanism Move to the second operating time expended needed for reagent adding station.Optionally, which can be the second reaction appearance Device is completed to incubate the remaining time of operation, is transferred to the reagent adding work reacted on outer disc mechanism 132 on disc mechanism 133 out of react The sum of the time that position is expended.Further, when the second operation corresponding by the second reaction vessel each on the reaction disc mechanism Between and current time at the time of can predict each second reaction vessel and move to reagent adding station.
S243, judge time interval between the first operating time and each second operating time whether when third is preset In.At the time of it is possible to further judge that the first reaction vessel moves to reagent adding station, transported with each second reaction vessel Whether time interval at the time of moving to same reagent adding station is in third preset time.Wherein, third preset time has been At the operating time needed for reagent adding operation.For example, the third preset time can be 3 seconds.
If between the time between the first operating time and more than one second reaction vessel corresponding second operating time It is interposed between in third preset time, thens follow the steps S263, determine that the first reaction vessel and the second reaction vessel will be in the same times Reagent adding operation is executed in section.For example, if the time interval of the first operating time and the second operating time are 0.1 second~2.9 seconds When, it, at this time can be with it may be considered that the time interval of first operating time and the second operating time is in third preset time Think that the first reaction vessel will can postpone to execute the first reaction vessel turn with the second reaction vessel there are the conflict in timing Move to the operation reacted on outer disc mechanism 132.Further, if the first operating time and the second operating time are equal, i.e., when One reaction vessel and the second reaction vessel will then follow the steps S263 when synchronization reaches reagent adding station, determine first Reaction vessel and the second reaction vessel will execute reagent adding operation within the same period.
Further, when between the time of the second operating time corresponding with each second reaction vessel the first operating time Every not in third preset time, i.e. the second operating time corresponding with each third reaction vessel the first operating time when Between interval be all larger than third preset time, then follow the steps S281, determine that the first reaction vessel and each second reaction vessel are equal It is non-interference.
In one embodiment, the third reaction vessel that cleaning operation is being carried out on cleaning device 14 may be completed After cleaning operation, it is transferred to measuring device and carries out detection operation.Alternatively, being carrying out the third of cleaning operation on cleaning device 14 Reaction vessel may be transferred on the outer disc mechanism 132 of reaction after completing cleaning operation, carry out reagent adding operation etc. again.Cause This, if current goal operation is reagent adding operation, above-mentioned preset time may include the 4th preset time, wherein the 4th Preset time is the operating time needed for completing reagent adding operation.At this point, if the first operating time and more than one third are anti- It answers the time interval between the container corresponding third operating time in the 4th preset time, then determines the first reaction vessel and Three reaction vessels will execute reagent adding operation within the same period.Wherein, the first operating time was the movement of the first reaction vessel The time that the current location postponed on punched disc mechanism 131 is expended needed for the reagent adding station to the setting of reaction disc mechanism side；The Three operating times be third reaction vessel move to reagent adding station from the current location on cleaning device 14 needed for consuming when Between.Specifically, as shown in figure 9, the object run when each reaction vessel is reagent adding operation, above-mentioned steps S200 is specifically wrapped It includes:
S214, the test item information according to the first reaction vessel, obtaining the first reaction vessel postpones on punched disc mechanism 131 Move to the first operating time expended needed for the reagent adding station of reaction disc mechanism side setting；Specifically, when this is first anti- When to answer container be reaction vessel in blank state, which can be the first reaction vessel and postpones punched disc mechanism The time reacted and expended on outer disc mechanism 132 is transferred on 131, and outer disc mechanism 132 is corresponding plus cup station is transported from reacting Move the summation for the time expended to reagent adding station.When first reaction vessel is the reaction vessel for being contained with sample, this One operating time can also include the time that sample-adding operation expends.Further, pass through first operating time and current time At the time of first reaction vessel can be predicted moving to reagent adding station.
S231, the test item information according to third reaction vessel obtain third reaction vessel and move to reagent adding station The third operating time of required consuming；It specifically, can be respectively according to the test of third reaction vessel each on cleaning device 14 Project information, obtain respectively each third reaction vessel from cleaning device 14 move to reagent adding station needed for consuming third behaviour Make the time.Optionally, which can be third reaction vessel and completes the remaining time of cleaning operation, fills from cleaning It sets to be transferred to react the time expended on outer disc mechanism 132 and put a glass station from cleaning on 14 and moves to the consuming of reagent adding station The sum of time.Further, by third reaction vessel each on the cleaning device 14 corresponding third operating time and work as At the time of the preceding moment can predict each third reaction vessel and move to reagent adding station.
S251, judge time interval between the first operating time and each third operating time whether when the 4th is default In.At the time of it is possible to further judge that the first reaction vessel moves to reagent adding station, transported with each third reaction vessel Whether time interval at the time of moving to same reagent adding station is in the 4th preset time.Wherein, the 4th preset time has been At the operating time needed for reagent adding operation.For example, the 4th preset time can be 3 seconds.
If between the time between the first operating time and more than one third reaction vessel corresponding third operating time It is interposed between in the 4th preset time, thens follow the steps S264, determine that the first reaction vessel and third reaction vessel will be in the same times Reagent adding operation is executed in section.For example, if the time interval of the first operating time and third operating time are 0.1 second~2.9 seconds When, it, at this time can be with it may be considered that the time interval of first operating time and third operating time is in the 4th preset time Think that the first reaction vessel will can postpone to execute the first reaction vessel turn with third reaction vessel there are the conflict in timing Move to the operation reacted on outer disc mechanism 132.Further, if the first operating time and third operating time are equal, i.e., when One reaction vessel and third reaction vessel will then follow the steps S264 when synchronization reaches reagent adding station, determine first Reaction vessel and third reaction vessel will execute same object run within the same period.
Further, when between the time of third operating time corresponding with each third reaction vessel the first operating time Every not within a preset time, i.e. between the time of third operating time corresponding with each third reaction vessel the first operating time Every being all larger than the 4th preset time, S282 is thened follow the steps, do not determine the first reaction vessel and each third reaction vessel mutually not Interference.
It should be understood that combining Fig. 6 to Fig. 9, each step in Fig. 6 can be performed simultaneously with each step in Fig. 9, Each step in Fig. 7 also may be performed simultaneously with each step in Fig. 9, each step in Fig. 8 and each step in Fig. 9 Suddenly it also may be performed simultaneously.Each step label in the present embodiment is only used for clearly stating the implementation procedure of this method, and Being not used in restriction, its executes sequence.
Further, when above-mentioned steps S281 and step S282 meets simultaneously, it can be said that bright first reaction vessel Do not interfere with each second reaction vessel and/or each third reaction vessel, then can execute step S400 at this time, controls sample Originally it grabs cup mechanism 162 and first reaction vessel punched disc mechanism 131 of postponing is transferred to reaction disc mechanism, so as to anti-according to first The test item of container is answered to carry out reagent adding operation, incubation operation, cleaning operation and detection operation etc. to first reaction vessel.
Optionally, as shown in figure 5, above-mentioned steps S400 includes the following steps:
S410, by the first reaction vessel postpone punched disc mechanism 131 be transferred to reaction disc mechanism operation, postpone one or more A buffer disc period of motion, until each object run and the second reaction vessel and the third reaction vessel of the first reaction vessel Each object run is non-interference.Wherein, the buffer disc period of motion refers to a loading hole on buffering disc mechanism 131 13111 move to total duration spent by target movement position from current location, which can carry for new cup Position, sample-adding position or transfer cup position.For example, the buffer disc period of motion can be 3 seconds.
Further, as shown in figure 5, the above method further includes following steps:
Whether the quantity of S600, the judgement delayed buffer disc period of motion are greater than or equal to preset threshold.Further Ground, the value range of preset threshold are 20~40, and the duration of each buffer disc period of motion is 3 seconds.If delayed The quantity of the buffer disc period of motion be greater than or equal to preset threshold, then follow the steps S700, the control pause of sample charging mechanism 122 is spat Sample operation is inhaled in sample operation or the control delay of sample charging mechanism 122.
Those of ordinary skill in the art will appreciate that realizing all or part of the process in above-described embodiment method, being can be with Relevant hardware is instructed to complete by computer program, the program can be stored in a computer-readable storage medium In, the program is when being executed, it may include such as the process of the embodiment of above-mentioned each method.Wherein, each implementation provided herein Any reference to memory, storage, database or other media used in example, may each comprise non-volatile and/or easy The property lost memory.Nonvolatile memory may include read-only memory (ROM), programming ROM (PROM), electrically programmable ROM (EPROM), electrically erasable ROM (EEPROM) or flash memory.Volatile memory may include random access memory (RAM) Or external cache.By way of illustration and not limitation, RAM is available in many forms, such as static state RAM (SRAM), It is dynamic ram (DRAM), synchronous dram (SDRAM), double data rate sdram (DDRSDRAM), enhanced SDRAM (ESDRAM), same Walk link (Synchlink) DRAM (SLDRAM), memory bus (Rambus) directly RAM (RDRAM), direct memory bus Dynamic ram (DRDRAM) and memory bus dynamic ram (RDRAM) etc..
Meanwhile one embodiment of the invention additionally provides a kind of control system of chemiluminescence detector, including processor and For storing the memory of computer program, the processor executes any of the above-described implementation when executing the computer program The method of example.Specifically, when the computer program that processor stores in executing memory, following steps are executed:
Obtain the test item information of each reaction vessel on chemiluminescence detector, wherein each reaction vessel Operating time needed for test item information includes the multiple object runs executed needed for reaction vessel, completes each object run And the current test operation of the reaction vessel, working as the reaction vessel, can get according to the current test operation of the reaction vessel The information such as front position.For example, the test item information of each reaction vessel may include that current sample is completed needed for entire detection The multiple object runs passed through, such as sample-adding operation, reagent adding operation mix operation, incubate operation, cleaning transfer operation, cleaning Operation and detection operation etc..The test item information of each reaction vessel can also include expending needed for completing each object run Operating time, and time needed for moving to the corresponding position of next object run from the corresponding position of current test operation Etc..
According to the test item information of each reaction vessel, judgement buffers the first reaction vessel on disc mechanism 131 respectively Whether same object run will be executed within the same period with multiple second reaction vessels reacted on disc mechanism；Wherein, should The same period can be the operating time expended needed for completing the object run.Specifically, which can be Need to postpone the reaction vessel being transferred on punched disc mechanism 131 on reaction disc mechanism, as first reaction vessel can be it is complete It can be at the reaction vessel or first reaction vessel of sample-adding operation and need the reaction cup in blank state, this is vacant The reaction vessel of state out of reagent storage means for obtaining destination agent.
According to the test item information of each reaction vessel, the first reaction vessel on judgement buffering disc mechanism and clear respectively Whether each third reaction vessel on cleaning device will execute same object run within the same period；Wherein, this is the same as the moment Between section can be complete the object run needed for expend operating time.
If the first reaction vessel and more than one second reaction vessel and/or more than one third reaction vessel will be Same object run is executed in the same period, then illustrates that the first reaction vessel reacts appearance with the second reaction vessel and/or third There are timing interference between the object run of device, which interferes the conflict that will lead to resource transfer, and delay executes anti-by first Answer container postpone punched disc mechanism 131 be transferred to reaction disc mechanism transfer operation, reacted to avoid the first reaction vessel with second The timing conflict problem of container and/or the second reaction vessel.
Further, first reaction vessel punched disc mechanism 131 of postponing is transferred to reaction disc mechanism when delay executes When transfer operation, can continue to judge at this time to buffer other first reaction vessels on disc mechanism whether with the second reaction vessel And/or there are the conflicts in timing for third reaction vessel, if existing on buffering disc mechanism anti-with the second reaction vessel and/or third When the reaction vessel for answering container not conflict, then the reaction vessel there is no conflict is preferentially postponed and be transferred on punched disc mechanism It reacts on disc mechanism.
Further, when delay execute by the first reaction vessel postpone punched disc mechanism 131 be transferred to reaction disc mechanism turn When moving operation, the pause of sample charging mechanism 122 can be controlled simultaneously and spits sample operation, or control delay a period of time of sample charging mechanism 122 is again It carries out inhaling sample operation.In this way can be too long to avoid sample exposure time in the first reaction vessel, lead to testing result inaccuracy etc. Problem.
It should be understood that the working principle of the control system of the present embodiment and above each step of control method Implementation procedure is almost the same, and for details, reference can be made to described above, details are not described herein again.
In addition, as shown in Figure 10, one embodiment of the invention also provides a kind of control system 900 of chemiluminescence detector, Including obtaining module 910, first judgment module 920, the second judgment module 930 and control module 940.Wherein, module is obtained 910 for obtaining the test item information of each reaction vessel on chemiluminescence detector, wherein test item information includes Operating time needed for the multiple object runs and each object run of completion that are executed needed for reaction vessel.First judgment module 920 for according to the test item information of each reaction vessel, respectively the first reaction vessel on judgement buffering disc mechanism 131 with Whether each second reaction vessel on reaction disc mechanism will execute same object run within the same period.Second judges mould Block 930 according to the test item information of each reaction vessel, respectively the first reaction vessel on judgement buffering disc mechanism with Whether each third reaction vessel on cleaning device will execute same object run within the same period.Control module 940 It, will be same in the first reaction vessel and more than one second reaction vessel and/or more than one third reaction vessel Same object run is executed in one period, then postpones to execute that the first reaction vessel punched disc mechanism 131 of postponing is transferred to reaction The operation of disc mechanism.
It should be understood that the working principle of modules and above control method in the control system of the present embodiment The implementation procedure of each step is almost the same, and for details, reference can be made to described above, details are not described herein again.
Further, the present invention one implements also a kind of chemiluminescence detector, including above-mentioned control system.Also, it should Chemiluminescence detector further include chemiluminescence detector may include pedestal 10, it is reagent storage means 11, dispenser 12, anti- It answers device 13, cleaning device 14, measuring device 15, grab cup device 16, reaction vessel conveying device 17, consumption material box loading device 18, the structures such as sample conveying device 19 and evenly mixing device, the structure and positional relationship of above-mentioned each device can be found in above Description.The control system can be used for controlling the movement of above-mentioned each device, improve the automatic of the chemiluminescence detector Change degree and detection accuracy, and by the setting of buffering disc mechanism, improve the detection efficiency of the chemiluminescence detector.
Control method, system and the chemiluminescence detector of chemiluminescence detector of the invention, can be by each anti- Answer the test item information of container, respectively the first reaction vessel on judgement buffering disc mechanism with react on disc mechanism each the Whether two reaction vessels will execute same object run within the same period, and first respectively on judgement buffering disc mechanism is anti- Answer whether each third reaction vessel on container and cleaning device will execute same object run within the same period；If sentencing Fixed first reaction vessel and more than one second reaction vessel and/or more than one third reaction vessel are in the same period When the same object run of interior execution, then illustrate that first reaction vessel and the second reaction vessel and/or third reaction vessel exist Conflict in timing, the conflict in the timing will lead to resource transfer conflict when completing same object run, at this point it is possible to logical Cross delay execute by the first reaction vessel postpone punched disc mechanism be transferred to reaction disc mechanism operation, to solve in detection process Resource transfer conflict is not present it is possible to further buffer on disc mechanism with the second reaction vessel and/or third reaction vessel Other first reaction vessels to conflict in timing are transferred on reaction disc mechanism, to improve the detection of the chemiluminescence detector Efficiency.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously Limitations on the scope of the patent of the present invention therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to guarantor of the invention Protect range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.

Claims (16)

1. a kind of control method of chemiluminescence detector, which is characterized in that described method includes following steps:
Obtain the test item information of each reaction vessel on chemiluminescence detector, wherein the test item packet Operating time needed for including the multiple object runs executed needed for the reaction vessel and completing each object run；
According to the test item information of each reaction vessel, the first reaction vessel on judgement buffering disc mechanism and anti-respectively Answer whether each second reaction vessel on disc mechanism will execute same object run within the same period；
According to the test item information of each reaction vessel, the first reaction vessel on judgement buffering disc mechanism and clear respectively Whether each third reaction vessel on cleaning device will execute same object run within the same period；
If first reaction vessel is reacted with more than one second reaction vessel and/or the more than one third Container will execute same object run within the same period, then postpone to execute first reaction vessel from the buffering Disc mechanism is transferred to the operation of the reaction disc mechanism.
2. the method according to claim 1, wherein according to the test item information of each reaction vessel, Judge whether the first reaction vessel buffered on disc mechanism will be same with each second reaction vessel reacted on disc mechanism respectively The step of same object run is executed in one period, comprising:
According to the test item information of first reaction vessel, obtain first reaction vessel from current location move to First operating time of current goal operation corresponding position；
Respectively according to the test item information of each second reaction vessel, each second reaction vessel is obtained from current Position moves to the second operating time of the current goal operation corresponding position；
If first operating time, second operating time corresponding with more than one second reaction vessel when Between be spaced within a preset time, then determine that first reaction vessel will be held with second reaction vessel within the same period The same object run of row；
Wherein, the preset time is the operating time needed for completing the current goal operation.
3. according to the method described in claim 2, it is characterized in that, the method also includes following steps:
If first operating time, second operating time corresponding with more than one second reaction vessel is equal, Then determine that first reaction vessel and second reaction vessel will execute same object run within the same period.
4. according to the method in claim 2 or 3, which is characterized in that the current goal operation is grasped for incubation will be completed The reaction vessel of work is transferred to the cleaning transfer operation of the cleaning device, and the preset time includes the first preset time, institute The method of stating further includes following steps:
If first operating time and more than one second reaction vessel corresponding second operating time when Between be spaced in first preset time, then determine that first reaction vessel and second reaction vessel will be in same a period of time Between the cleaning transfer operation is executed in section；
Wherein, first preset time be cleaning grab cup mechanism one reaction vessel is transferred to from reaction disc mechanism it is described clear The time expended needed for cleaning device；
First operating time is first reaction vessel from current location to the time for completing to expend needed for incubating operation；
Second operating time is that second reaction vessel is completed to incubate behaviour from current location to second reaction vessel The time expended needed for making.
5. according to the method in claim 2 or 3, which is characterized in that the current goal operation is that will react outer disc mechanism Upper reaction vessel is transferred to the sample transfer operation of the buffering disc mechanism, and the preset time includes the second preset time, institute The method of stating further includes following steps:
If first operating time and more than one second reaction vessel corresponding second operating time when Between be spaced in second preset time, then determine that first reaction vessel and second reaction vessel will be in same a period of time Between the sample transfer operation is executed in section；
Wherein, second preset time is that sample grabs cup mechanism for a reaction vessel from reacting described in outer disc mechanism is transferred to Buffer the time expended needed for disc mechanism；
First operating time is the transfer cup that first reaction vessel moves to buffering disc mechanism side from current location The time expended needed for position；
Second operating time moves to disc mechanism side outside the reaction from current location for second reaction vessel Add the time expended needed for glass station.
6. according to the method in claim 2 or 3, which is characterized in that the current goal operation is that reagent adding operates, described Preset time includes third preset time, the method also includes:
If between first operating time and more than one second reaction vessel corresponding second operating time Time interval in the third preset time, then determine that first reaction vessel will be same with second reaction vessel The reagent adding operation is executed in one period；
Wherein, the third preset time is the operating time needed for completing the reagent adding operation；
First operating time is that first reaction vessel movement is arranged from current location to the reaction disc mechanism side Reagent adding station needed for expend time；
Second operating time is consuming needed for second reaction vessel moves to the reagent adding station from current location Time.
7. the method according to claim 1, wherein according to the test item information of each reaction vessel, Judge whether the first reaction vessel buffered on disc mechanism will be same with each third reaction vessel on cleaning device respectively The step of same object run is executed in period, further includes:
According to the test item information of first reaction vessel, obtain first reaction vessel from current location move to First operating time of current goal operation corresponding position；
Respectively according to the test item information of the third reaction vessel, each third reaction vessel is obtained from current location Move to the third operating time with current goal operation corresponding position；
If the third operating time corresponding with the more than one third reaction vessel first operating time when Between be spaced within a preset time, then determine that first reaction vessel will be held with the third reaction vessel within the same period The same object run of row.
8. the method according to the description of claim 7 is characterized in that the method also includes following steps:
If the third operating time corresponding with the more than one third reaction vessel first operating time is equal, Then determine that first reaction vessel and the third reaction vessel will execute same object run within the same period.
9. method according to claim 7 or 8, which is characterized in that the current goal operation is that reagent adding operates, described Preset time includes the 4th preset time, the method also includes:
If between first operating time and the more than one third reaction vessel corresponding third operating time Time interval in the 4th preset time, then determine that first reaction vessel will be same with the third reaction vessel The reagent adding operation is executed in one period；
Wherein, the 4th preset time is the operating time needed for completing the reagent adding operation；
First operating time is that first reaction vessel movement is arranged from current location to the reaction disc mechanism side Reagent adding station needed for expend time；
The third operating time is consuming needed for the third reaction vessel moves to the reagent adding station from current location Time.
10. the method according to claim 1, wherein the delay execute by first reaction vessel from Buffering disc mechanism is transferred to the operation of the reaction disc mechanism, comprising:
First reaction vessel punched disc mechanism of postponing is transferred to the operation of the reaction disc mechanism, is postponed one or more slow The punch plate period of motion, until each object run of first reaction vessel and second reaction vessel and the third are anti- Answer each object run of container non-interference.
11. according to the method described in claim 10, it is characterized in that, the method also includes following steps:
If the quantity of the delayed buffer disc period of motion is greater than or equal to preset threshold, controls sample charging mechanism pause and spit sample It operates or controls the sample charging mechanism delay and inhale sample operation.
12. according to the method for claim 11, which is characterized in that the value range of the preset threshold is 20~40, The duration of each buffer disc period of motion is 3 seconds.
13. according to the method described in claim 10, it is characterized in that, the method also includes following steps:
When first reaction vessel and each second reaction vessel and each third reaction vessel are non-interference When, then it controls sample and grabs cup mechanism first reaction vessel is transferred to the reaction disc mechanism from the buffering disc mechanism.
14. a kind of control system of chemiluminescence detector characterized by comprising
Module is obtained, for obtaining the test item information of each reaction vessel on chemiluminescence detector, wherein the survey Examination project information includes the multiple object runs executed needed for the reaction vessel and completes needed for each object run Operating time；
First judgment module, for the test item information according to each reaction vessel, respectively on judgement buffering disc mechanism The first reaction vessel whether same mesh will be executed within the same period with each second reaction vessel reacted on disc mechanism Mark operation；
Second judgment module, for the test item information according to each reaction vessel, respectively on judgement buffering disc mechanism The first reaction vessel and cleaning device on each third reaction vessel whether same target will be executed within the same period Operation；
Control module, for first reaction vessel and more than one second reaction vessel and/or more than one The third reaction vessel, same object run will be executed within the same period, then postpone execute described first is reacted Container is transferred to the operation of the reaction disc mechanism from the buffering disc mechanism.
15. a kind of control system of chemiluminescence detector, which is characterized in that including processor and for storing computer program Memory, the processor executes when executing the computer program such as the described in any item methods of claim 1-13.
16. a kind of chemiluminescence detector, which is characterized in that including the control system as described in claims 14 or 15.
CN201711462165.0A 2017-12-28 2017-12-28 Control method and system of chemiluminescence detector and chemiluminescence detector Active CN109975276B (en)

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