CN109975276B

CN109975276B - Control method and system of chemiluminescence detector and chemiluminescence detector

Info

Publication number: CN109975276B
Application number: CN201711462165.0A
Authority: CN
Inventors: 汤俊辉; 邱小明; 吴锦洪; 胡毅; 李江; 刘芬
Original assignee: Shenzhen New Industries Biomedical Engineering Co Ltd
Current assignee: Shenzhen New Industries Biomedical Engineering Co Ltd
Priority date: 2017-12-28
Filing date: 2017-12-28
Publication date: 2021-11-02
Anticipated expiration: 2037-12-28
Also published as: CN109975276A

Abstract

The invention provides a control method of a chemiluminescence detector, which comprises the following steps: acquiring test item information of each reaction container on the chemiluminescence detector; respectively judging whether the first reaction container on the buffer disc mechanism and each second reaction container on the reaction disc mechanism execute the same target operation in the same time period; respectively judging whether the first reaction container on the buffer disc mechanism and each third reaction container on the cleaning device execute the same target operation in the same time period; if the first reaction vessel and one or more second reaction vessels and/or one or more third reaction vessels are to perform the same target operation within the same time period, the operation of transferring the first reaction vessel from the buffer tray mechanism to the reaction tray mechanism is delayed. The control method and system of the chemiluminescence detector and the chemiluminescence detector solve resource calling conflict in the detection process and improve the detection efficiency of the chemiluminescence detector.

Description

Control method and system of chemiluminescence detector and chemiluminescence detector

Technical Field

The invention relates to the technical field of chemiluminescence detection, in particular to a control method and a control system of a chemiluminescence detector and the chemiluminescence detector.

Background

The chemiluminescence immune analysis method is an in vitro detection analysis technology combining antigen-antibody immune reaction and luminescence reaction, which is based on the immunological theory, takes a luminescence marker as a tracing signal, and detects various markers by collecting light signals, and has the advantages of high sensitivity, low nonspecific adsorption and high accuracy. With the rapid development of biomedical equipment, the realization of the full automation of the chemiluminescence detector has certain conditions.

The chemiluminescence detector mainly comprises a reaction cup loading device, a dispensing device, a reagent storage device, an incubation reaction device, a cleaning device, a measuring device and the like, wherein the dispensing device, the reagent storage device, the cleaning device, the measuring device and the like are arranged on the peripheral side of the incubation reaction device, and reaction stations corresponding to the dispensing device, the reagent storage device, the cleaning device and the like are arranged on the peripheral side of the incubation reaction device. When the incubation reaction device drives the reaction cups loaded on the incubation reaction device to rotate to each reaction station, the device corresponding to the reaction station can act and complete corresponding operation. At the same time, when more than two cuvettes need to perform the same operation, for example, two cuvettes need to use the same reagent needle to perform reagent adding operation, resource calling conflict may occur, and even the instrument may be locked, thereby affecting the detection efficiency of the instrument.

Disclosure of Invention

In view of the current situation of the prior art, an object of the present invention is to provide a control method and system for a chemiluminescence detector, and a chemiluminescence detector, which can solve resource calling conflicts in the detection process and improve the detection efficiency of the chemiluminescence detector.

In order to achieve the purpose, the invention adopts the following technical scheme:

a method of controlling a chemiluminescent detector, the method comprising the steps of:

acquiring test item information of each reaction container on a chemiluminescence detector, wherein the test item information comprises a plurality of target operations to be executed by the reaction container and operation time required for completing each target operation;

respectively judging whether a first reaction container on the buffer disc mechanism and each second reaction container on the reaction disc mechanism execute the same target operation in the same time period according to the test item information of each reaction container;

respectively judging whether the first reaction container on the buffer disc mechanism and each third reaction container on the cleaning device execute the same target operation in the same time period according to the test item information of each reaction container;

and delaying the execution of the operation of transferring the first reaction vessel from the buffer tray mechanism to the reaction tray mechanism if the first reaction vessel and one or more second reaction vessels and/or one or more third reaction vessels are to execute the same target operation within the same period of time.

In one embodiment, the step of determining whether the first reaction container on the buffer tray mechanism and the second reaction container on the reaction tray mechanism will perform the same target operation in the same time period according to the test item information of each reaction container includes:

according to the test item information of the first reaction container, obtaining first operation time of the first reaction container moving from the current position to a position corresponding to the current target operation;

respectively obtaining second operation time of each second reaction container from the current position to the position corresponding to the current target operation according to the test item information of each second reaction container;

if the time interval between the first operation time and the second operation time corresponding to more than one second reaction container is within a preset time, determining that the first reaction container and the second reaction container execute the same target operation within the same time period;

and the preset time is the operation time required for completing the current target operation.

In one embodiment, the method further comprises the steps of:

and if the first operation time is equal to the second operation time corresponding to more than one second reaction container, judging that the first reaction container and the second reaction container execute the same target operation in the same time period.

In one embodiment, the current target operation is a wash transfer operation of transferring the reaction vessel for which the incubation operation has been completed to the washing device, the preset time includes a first preset time, and the method further includes the steps of:

if the time interval between the first operation time and the second operation time corresponding to more than one second reaction vessel is within the first preset time, determining that the cleaning and transferring operations are to be executed in the same time period by the first reaction vessel and the second reaction vessel;

wherein the first preset time is the time consumed for cleaning the cup grabbing mechanism to transfer one reaction container from the reaction disc mechanism to the cleaning device;

the first operation time is the time taken by the first reaction vessel from the current position to the completion of the incubation operation;

the second operation time is a time taken for the second reaction vessel to complete an incubation operation from a current position to the second reaction vessel.

In one embodiment, the current target operation is a sample transfer operation of transferring reaction containers on the reaction outer tray mechanism to the buffer tray mechanism, the preset time includes a second preset time, and the method further includes the steps of:

if the time interval between the first operation time and the second operation time corresponding to more than one second reaction container is within the second preset time, determining that the first reaction container and the second reaction container will execute the sample transfer operation within the same time period;

wherein the second preset time is the time consumed by the sample cup grabbing mechanism for transferring one reaction container from the reaction outer tray mechanism to the buffer tray mechanism;

the first operation time is the time consumed by the first reaction container to move from the current position to the transfer cup position on the peripheral side of the buffer disc mechanism;

the second operation time is the time consumed by the second reaction container to move from the current position to the cup adding station on the periphery of the reaction outer disc mechanism.

In one embodiment, the current target operation is a reagent adding operation, the preset time includes a third preset time, and the method further includes:

if the time interval between the first operation time and the second operation time corresponding to more than one second reaction container is within the third preset time, determining that the first reaction container and the second reaction container will execute the reagent adding operation within the same time period;

wherein the third preset time is the operation time required for completing the reagent adding operation;

the first operation time is the time consumed by the first reaction container to move from the current position to a reagent adding station arranged on the periphery of the reaction disc mechanism;

the second operating time is the time it takes for the second reaction vessel to move from the current position to the reagent addition station.

In one embodiment, the step of determining whether the first reaction container on the buffer tray mechanism and each third reaction container on the cleaning device will perform the same target operation in the same time period according to the test item information of each reaction container further comprises:

respectively obtaining third operation time of each third reaction container from the current position to a position corresponding to the current target operation according to the test item information of the third reaction container;

and if the time interval between the first operation time and the third operation time corresponding to more than one third reaction vessel is within a preset time, determining that the first reaction vessel and the third reaction vessel execute the same target operation within the same time period.

In one embodiment, the method further comprises the steps of:

and if the first operation time is equal to the third operation time corresponding to more than one third reaction vessel, determining that the first reaction vessel and the third reaction vessel execute the same target operation in the same time period.

In one embodiment, the current target operation is a reagent adding operation, the preset times include a fourth preset time, and the method further includes:

if the time interval between the first operation time and the third operation time corresponding to more than one third reaction vessel is within the fourth preset time, determining that the first reaction vessel and the third reaction vessel will execute the reagent adding operation within the same time period;

wherein the fourth preset time is the operation time required for completing the reagent adding operation;

the third operating time is the time it takes for the third reaction vessel to move from the current position to the reagent addition station.

In one embodiment, said delaying performing the transferring of said first reaction vessel from the buffer tray mechanism to said reaction tray mechanism comprises:

transferring the first reaction vessel from the buffer tray mechanism to the operation of the reaction tray mechanism, delaying one or more buffer tray movement cycles until each target operation of the first reaction vessel does not interfere with each target operation of the second reaction vessel and the third reaction vessel.

In one embodiment, the method further comprises the steps of:

and if the number of the delayed motion cycles of the buffer disc is greater than or equal to a preset threshold value, controlling the sample feeding mechanism to pause sample spitting operation or controlling the sample feeding mechanism to delay sample sucking operation.

In one embodiment, the preset threshold ranges from 20 to 40, and the duration of each buffer disc motion period is 3 seconds.

In one embodiment, the method further comprises the steps of:

when the first reaction container and each second reaction container and each third reaction container do not interfere with each other, controlling a sample cup grabbing mechanism to transfer the first reaction container from the buffer tray mechanism to the reaction tray mechanism.

Meanwhile, the invention also provides a control system of the chemiluminescence detector, which comprises the following components:

the system comprises an acquisition module, a detection module and a processing module, wherein the acquisition module is used for acquiring test item information of each reaction container on a chemiluminescence detector, and the test item information comprises a plurality of target operations required to be executed by the reaction container and operation time required for completing each target operation;

the first judgment module is used for respectively judging whether the first reaction container on the buffer disc mechanism and each second reaction container on the reaction disc mechanism execute the same target operation in the same time period according to the test item information of each reaction container;

the second judging module is used for respectively judging whether the first reaction container on the buffer disc mechanism and each third reaction container on the cleaning device execute the same target operation in the same time period according to the test item information of each reaction container;

and a control module for delaying execution of an operation of transferring the first reaction vessel from the buffer tray mechanism to the reaction tray mechanism if the same target operation is to be executed in the same time period in the first reaction vessel and one or more second reaction vessels and/or one or more third reaction vessels.

The invention also provides a control system of the chemiluminescence detector, which comprises a processor and a memory for storing a computer program, wherein the processor executes the computer program to execute the method.

Finally, the invention also provides a chemiluminescence detector which comprises the control system.

The invention has the technical effects that:

according to the control method and system of the chemiluminescence detector and the chemiluminescence detector, whether the first reaction container on the buffer disc mechanism and each second reaction container on the reaction disc mechanism execute the same target operation in the same time period or not can be respectively judged according to the test item information of each reaction container, and whether the first reaction container on the buffer disc mechanism and each third reaction container on the cleaning device execute the same target operation in the same time period or not can be respectively judged; if it is determined that the first reaction vessel and the one or more second reaction vessels and/or the one or more third reaction vessels execute the same target operation in the same time period, it is determined that there is a time sequence conflict between the first reaction vessel and the second reaction vessel and/or the third reaction vessel, where the time sequence conflict will result in a resource call conflict when the same target operation is completed, at this time, the operation of transferring the first reaction vessel from the buffer tray mechanism to the reaction tray mechanism may be performed with a delay to resolve the resource call conflict during the detection process, and other first reaction vessels on the buffer tray mechanism that do not have a time sequence conflict with the second reaction vessel and/or the third reaction vessel may be transferred to the reaction tray mechanism, thereby improving the detection efficiency of the chemiluminescence detector.

Drawings

FIG. 1 is a schematic structural diagram of a chemiluminescent detector according to one embodiment;

FIG. 2 is a schematic structural diagram of an embodiment of the buffer tray mechanism of FIG. 1;

FIG. 3 is a schematic structural diagram of an embodiment of the reaction disk mechanism in FIG. 1;

FIG. 4 is a flowchart illustrating a method for controlling a chemiluminescent detector according to one embodiment;

FIG. 5 is a flowchart illustrating a method for controlling a chemiluminescent detector according to one embodiment;

FIG. 6 is a flowchart illustrating a method for controlling a chemiluminescent detector according to one embodiment;

FIG. 7 is a flowchart illustrating a method for controlling a chemiluminescent detector according to one embodiment;

FIG. 8 is a flow chart illustrating a method for controlling a chemiluminescent detector according to one embodiment;

FIG. 9 is a flow chart illustrating a method for controlling a chemiluminescent detector according to one embodiment;

FIG. 10 is a system block diagram of a control system of the chemiluminescence detector according to one embodiment.

Detailed Description

In order to make the technical scheme of the present invention clearer, the following describes a control method and system of the chemiluminescence detector of the present invention and the chemiluminescence detector in further detail with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.

It should be noted that the ordinal numbers used herein for the components, such as "first", "second", etc., are used solely to distinguish the objects so described, and do not have any ordinal or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings). In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention.

In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

As shown in fig. 1, the chemiluminescence detector according to an embodiment of the present invention can process a sample, and analyze and detect the processed sample to obtain a corresponding detection result, thereby meeting the use requirement. It should be noted that the specific type of sample to be tested is not limited, and in some embodiments, the sample to be tested includes a solid sample or a liquid sample. Further, liquid samples include, but are not limited to, blood samples. The chemiluminescence detector of the embodiment can perform reagent adding, mixing, incubation and the like according to the processing time sequence requirements of different samples, can meet the processing requirements of different samples, enables the samples and the reagents to fully react, and improves the accuracy of sample detection results.

Specifically, as shown in fig. 1 and 2, the chemiluminescent detection instrument may include a base 10, a reagent storage device 11, a dispensing device 12, a reaction device 13, a cleaning device 14, a measuring device 15, and a cup grasping device 16, wherein the reagent storage device 11, the dispensing device 12, the reaction device 13, the cleaning device 14, the measuring device 15, the cup grasping device 16, and the like are all disposed on the base 10. The reaction device 13 is used for carrying the reaction container 20 and is used for operations such as adding a sample, adding a reagent, uniformly mixing, incubating and the like. Alternatively, the reaction container 20 refers to a consumable material, such as a reaction cup, a test tube, a sample slide, a sample tube, etc., which carries and enables a sample detection analysis. The reagent storage means 11 is provided at an edge position of the base 10, and the reagent storage means 11 is disposed on a peripheral side of the reaction means 13 for storing a reagent. The dispensing device 12 is provided on the periphery of the reaction device 13, and the dispensing device 12 can add a sample and/or a reagent into a reaction vessel carried on the reaction device 13. The cleaning device 14 is disposed on the periphery of the reaction device 13, the cleaning device 14 is used for removing impurities in the reaction container 20 after incubation, and the measuring device 15 is used for detecting the object to be detected in the reaction container 20. The cup grasping device 16 is used for realizing the transfer of the reaction container 20 among the reaction device 13, the cleaning device 14 and the measuring device 15 so as to realize the automatic analysis and detection of the sample and improve the operation efficiency.

Alternatively, the reaction apparatus 13 includes a buffer tray mechanism 131 and a reaction tray mechanism, and the buffer tray mechanism 131 operates independently from the reaction tray mechanism. As shown in fig. 2, the buffer tray mechanism 131 includes a rotatable buffer carrier tray 1311 and a buffer driving structure 1313 in transmission connection with the buffer carrier tray 1311, and the buffer driving structure 1313 can drive the buffer carrier tray 1311 to rotate. Further, the buffer tray 1311 has a disk shape, but in other embodiments of the present invention, the buffer tray 1311 may have an oval shape, a square shape, or another shape capable of supporting the reaction vessel 20. Alternatively, a plurality of loading wells 13111 for placing reaction vessels 20 are provided on the buffer tray 1311, and the plurality of loading wells 13111 are arranged in a row in the radial direction on the buffer tray 1311, so that the loading wells 13111 can be arranged in order on the buffer tray 1311. Further, after the loading holes 13111 are arranged in a row, the loading holes 13111 with equal radius are distributed in a circle along the connection line in the circumferential direction, and the loading holes 13111 distributed in a circle are arranged in a concentric circle around the center of the buffer tray 1311, so that the loading holes 13111 are distributed in a radial shape with respect to the center of the buffer tray 1311.

Optionally, as shown in fig. 1, the chemiluminescence detector further comprises a reaction vessel conveying device 17 disposed at an edge position of the base 10, and the reaction vessel conveying device 17 is used for conveying a new reaction vessel. The cup grasping device 16 may include a new cup grasping mechanism 161 and a sample grasping mechanism 162, wherein the new cup grasping mechanism 161 is disposed on the periphery side of the reaction vessel transport device 17, and the new cup grasping mechanism 161 can transfer a new reaction vessel in the reaction vessel transport device 17 onto the buffer tray mechanism 131. The sample cup grasping mechanism 162 is provided corresponding to the reaction outer tray mechanism 132 and the buffer tray mechanism 131, and is used to transfer the reaction vessel 20 from the reaction outer tray mechanism 132 to the buffer tray mechanism 131, or to transfer the reaction vessel 20 from the buffer tray mechanism 131 to the reaction outer tray mechanism 132. Alternatively, the dispensing device 12 may include a sample addition mechanism 121 disposed on the periphery of the buffer disk mechanism 131 and a pipetting mechanism 122 disposed on the periphery of the reagent storage device.

Accordingly, a new cup loading position, a transfer cup position, and a sample addition position are provided on the peripheral side of the buffer tray mechanism 131. Thus, when the buffer driving mechanism 1313 drives an empty loading hole on the buffer tray 1311 to align with a new cup loading position, the new cup catching mechanism 161 can place a new reaction container onto the buffer tray mechanism 131. When the buffer driving structure 1313 drives the loading hole of one loaded reaction container on the buffer tray 1311 to align with the sample loading position, the sample loading mechanism 121 can spit a sample into the reaction container placed at the sample loading position, so that a new cup loading operation and a sample loading operation can be performed on the buffer tray 131. When the buffer driving mechanism 1313 drives the loading hole of one loaded reaction container on the buffer tray 1311 to correspond to the transfer cup position, the sample cup catching mechanism 162 can transfer the reaction container on the buffer tray mechanism to the reaction outer tray mechanism. Of course, the sample cup-grasping mechanism 162 may also transfer the reaction container in the transfer cup position on the reaction outer tray mechanism to the buffer tray mechanism 131.

As shown in fig. 3, the reaction disk mechanism may include a reaction inner disk mechanism 133 and a reaction outer disk mechanism 132 which operate independently, and the reaction outer disk mechanism 132 is sleeved outside the reaction inner disk mechanism 133. Further, the reaction outer disk mechanism 132 may be disposed coaxially with the reaction inner disk mechanism 133. The reaction outer tray mechanism 132 can accommodate the reaction vessel 20 and perform the reagent adding and mixing operation, and the reaction inner tray mechanism 133 can accommodate the reaction vessel 20 and perform the incubation operation. As shown in fig. 1, the buffer tray mechanism 131 is provided on the peripheral side of the reaction outer tray mechanism 132, and the buffer tray mechanism 131 is interposed between the reaction outer tray mechanism 132 and the reaction vessel transport device 17.

Optionally, a plurality of reaction stations are disposed on the periphery of the reaction outer disk mechanism 132, including a cup adding station, a reagent adding station, a blending station, a cup taking station for incubation and a cup placing station for cleaning, and the cup adding station, the cup placing station for cleaning, the reagent adding station, the blending station and the cup taking station for incubation do not change along with the rotation of the reaction outer disk mechanism 132, wherein the cup adding station corresponds to the transfer cup disposed on the periphery of the buffer disk mechanism 131, and further, the cup adding station and the transfer cup disposed on the periphery of the buffer disk mechanism 131 may be at the same position. Accordingly, as shown in fig. 3, the reaction outer tray mechanism 132 includes a reaction outer tray 1321, a plurality of accommodating positions 13211 are disposed on the reaction outer tray 1321, and the plurality of accommodating positions 13211 are disposed along a circumferential direction of the reaction outer tray mechanism 132. The reaction outer tray driving structure can drive the reaction outer tray 1321 to drive the reaction containers 20 thereon to rotate to the corresponding reaction stations, and perform corresponding operations at the reaction stations. For example, when one of the receiving sites 13211 of the reaction outer tray mechanism 132 is aligned with the cup adding station, the sample cup grasping mechanism 162 may transfer the reaction vessel from the reaction outer tray mechanism 132 to the buffer tray mechanism 131, or transfer the reaction vessel from the buffer tray mechanism 131 to the reaction outer tray mechanism 132. When one of the receiving positions of the reaction outer tray mechanism 132 is aligned with the reagent adding station, the pipetting mechanism 122 may add a reagent to a reaction vessel placed at the reagent adding position. When one receiving position of the reaction outer tray mechanism 132 is aligned with the cup cleaning and placing station, the reaction vessel can be transferred between the cleaning device 14 and the reaction tray mechanism, and the other stations operate in a similar manner, which is not illustrated herein.

Optionally, the cup grasping device 16 further comprises an incubation cup grasping mechanism 163, a cleaning cup grasping mechanism 164, and a measurement cup grasping mechanism 165, wherein the cleaning cup grasping mechanism 164 is disposed corresponding to the cleaning device 14 and the reaction tray mechanism for transferring the reaction vessel 20 between the reaction tray mechanism and the cleaning device 14. Specifically, when one of the receiving positions of the reaction outer tray mechanism 132 is aligned with the washing and cup placing position, the washing and cup grasping mechanism 164 can transfer the reaction vessel incubated on the reaction inner tray mechanism 133 to the washing apparatus 14; alternatively, when the washed reaction vessel needs to be subjected to a reagent adding operation again, the washing cup-grasping mechanism 164 may transfer the reaction vessel on the washing apparatus 14 to the accommodating position of the reaction outer tray mechanism 131 corresponding to the washing cup-placing station. The incubation cup-grasping mechanism 163 is provided corresponding to the reaction outer tray mechanism 132 and the reaction inner tray mechanism 133 for effecting transfer of the reaction vessel 20 between the reaction outer tray mechanism 132 and the reaction inner tray mechanism 133. The measuring cup-grasping mechanism 165 is provided in correspondence with the cleaning device 14 and the measuring device 15, and is used for transferring the reaction vessel 20 cleaned in the cleaning device 14 to the measuring device 15.

It should be noted that the new cup gripping mechanism 161, the sample cup gripping mechanism 162, the incubation cup gripping mechanism 163, the cleaning cup gripping mechanism 164, and the measurement cup gripping mechanism 165 may employ a cup gripping driving assembly, a cup gripping control assembly, a cup gripping arm assembly, and the like to grip and transfer the reaction vessel 20. It is understood that the cup grasping control assembly may employ a general control system such as a controller, etc., and the cup grasping drive assembly may employ a drive motor in conjunction with a gear assembly, a belt assembly, or a chain drive assembly, etc. to control the movement of the cup grasping arm assembly such that the cup grasping arm assembly moves in both horizontal and vertical directions to ensure that the cup grasping arm assembly moves into position and grasps the transfer reaction vessel 20. Also, the end of the gripper arm assembly has a gripper by which to grip the reaction vessel 20.

Alternatively, the reagent storage apparatus 11 includes two reagent storage mechanisms 111 arranged in parallel, the number of the pipetting mechanisms 122 may be two, and the two pipetting mechanisms 122 are provided corresponding to the two reagent storage mechanisms 111. Further, the number of reagent adding stations is also two, and the reagent adding stations correspond to the arrangement of the two reagent storage mechanisms 111 and the two liquid transfer mechanisms 122 respectively, so that the reagent transferring efficiency is improved, and the running speed of the instrument is further improved. Furthermore, the two reagent adding stations can be respectively marked as a first reagent adding station and a second reagent adding station, and the cup adding station, the cup cleaning and placing station, the first reagent adding station, the second reagent adding station, the blending station and the incubation cup taking station are sequentially arranged along the circumferential direction of the reaction outer disc mechanism.

Optionally, the chemiluminescence detector may further comprise a mixing device and a sample conveying device 19, etc. disposed on the base 10. Wherein, the mixing device sets up on reaction outer dish mechanism 132 to correspond the mixing station setting, this mixing device is used for carrying out the mixing operation to the solution in the reaction vessel. The sample transport device 19 is disposed at an edge position of the base 10, and is configured to transport a sample to a sample sucking position, the sample sucking position is located at a peripheral side of the buffer tray mechanism 131 and is disposed corresponding to the sample adding mechanism 121, and the sample adding mechanism 121 sucks the sample at the sample sucking position and transfers the sample to a reaction container of the buffer tray mechanism 131.

Optionally, the chemiluminescence detector further comprises a control system for automatically controlling the scheduling of the reaction vessels on the buffer tray mechanism 131. Specifically, the control system may control the new-cup grasping mechanism 161 to load a new reaction container onto the buffer tray mechanism 131, and the sample adding mechanism 121 may add a sample to the reaction container on the buffer tray mechanism 131. Thereafter, the control system can control the reaction container with the added sample to be transferred to the reaction tray mechanism for reagent adding operation and incubation operation, and transfer the reaction container after the incubation is completed to the washing device 14 for washing operation. After the cleaning operation of the reaction container is completed, the cleaned reaction container may be transferred to the measuring device 15 for performing a detection operation, or the cleaned reaction container may be transferred to the reaction outer tray mechanism 132 for performing a secondary reagent adding operation, and the like, according to the test item information of the reaction container. Since the test items of the respective reaction vessels are different, there may be a case where two or more reaction vessels need to perform the same operation at the same time, for example, two or more reaction vessels need to be subjected to reagent addition operation using the same liquid transfer mechanism 122 at the same time, or two or more reaction vessels need to be transferred from the reaction inner tray mechanism 133 to the washing apparatus 14 using the washing and cup grasping mechanism 164 at the same time, that is, there is a conflict of resource calls between the two or more reaction vessels.

To solve the conflict of resource calling, the control system first determines whether there is time-series interference between the first reaction container on the buffer tray mechanism 131 and the second reaction containers on the reaction tray mechanism and/or the third reaction containers on the cleaning device 14 before controlling the first reaction container to transfer to the reaction tray mechanism, i.e. determines whether the first reaction container on the buffer tray mechanism 131 and each second reaction container on the reaction tray mechanism and/or each third reaction container on the cleaning device 14 will execute the same target operation in the same time slot. If the control system determines that the first reaction vessel and the one or more second reaction vessels and/or the one or more third reaction vessels execute the same target operation in the same time period, it indicates that there is a time sequence conflict between the first reaction vessel and the second reaction vessel and/or the third reaction vessel, and the time sequence conflict will result in a resource call conflict when the same target operation is completed. Further, when the operation of transferring the first reaction container from the buffer tray mechanism to the reaction tray mechanism is delayed, it is also possible to control the sample addition mechanism 121 to suspend the sample addition operation or control the sample addition mechanism 121 to delay the sample aspiration operation.

As shown in fig. 4, a control method of a chemiluminescence detector according to an embodiment of the present invention is used in the chemiluminescence detector to implement scheduling control of reaction containers on the chemiluminescence detector and automatic control of other devices on the chemiluminescence detector. Specifically, the method comprises the following steps:

s100, obtaining test item information of each reaction container on the chemiluminescence detector, wherein the test item information of each reaction container comprises a plurality of target operations to be executed by the reaction container, operation time required for completing each target operation, current test operation of the reaction container and the like, and the information of the current position of the reaction container and the like can be obtained according to the current test operation of the reaction container. For example, the test item information of each reaction container may include a plurality of target operations required by the current reaction container to complete the entire test, such as a sample adding operation, a reagent adding operation, a mixing operation, an incubation operation, a washing and transferring operation, a washing operation, a testing operation, and the like. The test item information of each reaction vessel may further include an operation time taken to complete each target operation, a time required to move from a position corresponding to a current test operation to a position corresponding to a next target operation, and the like.

Further, when the reaction container is placed on the buffer tray mechanism 131 for sample adding operation, the control system may obtain the test item information of the current sample according to the sample identification information of the current sample absorbed by the sample adding mechanism 122, for example, the control system may scan a barcode or an RFID tag on a container such as a test tube containing the current sample to obtain the sample identification information of the current sample. When the sample adding mechanism 122 adds the current sample sucked by the sample adding mechanism into the reaction container on the buffer tray, the test item information of the current sample is the test item information of the reaction container. Of course, the control system may also obtain the test item information of the reaction container according to the information such as the label of the reaction container. For example, the control system selects a reaction container in an empty state on the buffer tray mechanism 131 to perform a reagent taking operation, such as taking a diluent or a calibration solution, and the selected reaction container may have a number 1, so that the control system may obtain test item information of the reaction container according to the number of the reaction container 1 and related operations to be performed.

S200, respectively judging whether the first reaction container on the buffer disc mechanism 131 and each second reaction container on the reaction disc mechanism execute the same target operation in the same time period according to the test item information of each reaction container; wherein the same time period may be an operation time required to complete the target operation. Specifically, the first reaction container may be a reaction container that needs to be transferred from the buffer tray mechanism 131 to the reaction tray mechanism, for example, the first reaction container may be a reaction container that has completed the sample adding operation, or the first reaction container may be a reaction cup that needs to be in an empty state for obtaining the target reagent from the reagent storage device. Of course, the first reaction container may be any other reaction container on the buffer tray mechanism 131 that can be transferred to the reaction outer tray mechanism.

S300, respectively judging whether the first reaction container on the buffer disc mechanism 131 and each third reaction container on the cleaning device 14 execute the same target operation in the same time period according to the test item information of each reaction container; wherein the same time period may be an operation time required to complete the target operation.

If the first reaction container and the one or more second reaction containers and/or the one or more third reaction containers execute the same target operation in the same time period, it indicates that there is a timing interference between the target operations of the first reaction container and the second reaction container and/or the third reaction container, and the timing interference will cause a conflict of resource calling, at this time, step S400 may be executed to delay the execution of the transfer operation of transferring the first reaction container from the buffer tray mechanism 131 to the reaction tray mechanism, so as to avoid the timing conflict problem between the first reaction container and the second reaction container and/or the third reaction container. Further, when the transfer operation of transferring the first reaction container from the buffer tray mechanism 131 to the reaction tray mechanism is delayed, the sample application mechanism 122 may be simultaneously controlled to suspend the sample discharge operation, or the sample application mechanism 122 may be controlled to delay a period of time before the sample application operation. Therefore, the problems that the sample in the first reaction container is exposed for too long time, the detection result is inaccurate and the like can be avoided. Further, when the transfer operation of transferring the first reaction container from the buffer tray mechanism 131 to the reaction tray mechanism is delayed, it may be continuously determined whether there is a time-series conflict between the other first reaction containers on the buffer tray mechanism and the second reaction container and/or the third reaction container, and if there is a reaction container on the buffer tray mechanism that does not conflict with the second reaction container and/or the third reaction container, the reaction container without a conflict is preferentially transferred from the buffer tray mechanism to the reaction tray mechanism.

Further, when the first reaction container and each of the second reaction containers and each of the third reaction containers do not interfere with each other, that is, the reagent adding operation, the cleaning transfer operation, the detection operation, etc. of the first reaction container do not conflict with each of the second reaction containers or each of the third reaction containers in time sequence, step S500 may be executed to control the sample gripping mechanism 162 to transfer the first reaction container from the buffer tray mechanism 131 to the reaction tray mechanism, so that the reagent adding operation, the incubation operation, the cleaning operation, the detection operation, etc. may be performed on the first reaction container according to the test items of the first reaction container.

Further, as shown in fig. 5, the method specifically includes the following steps:

s210, according to the test item information of the first reaction container, obtaining first operation time of the first reaction container from the current position to a position corresponding to the current target operation; specifically, the current position of the first reaction container may be a sample addition position or a transfer cup position on the peripheral side of the buffer tray mechanism 131, etc., and the current target operation may be a reagent addition operation, an incubation operation, a washing transfer operation or a detection operation, etc. The first operation time may be a time required for the first reaction container on the buffer tray mechanism 131 to move from the current position to the reagent adding station corresponding to the reagent adding operation, or may be a sum of a time required for the first reaction container on the buffer tray mechanism 131 to move from the current position to the reaction inner tray mechanism and an incubation time, i.e., the first operation time may be a time required for the first reaction container to complete the incubation operation.

S220, respectively obtaining second operation time of each second reaction container from the current position to the position corresponding to the current target operation according to the test item information of each second reaction container; specifically, the current position of the second reaction vessel may be a reagent adding position, a mixing position, an incubation cup taking position, an incubation position on the reaction inner tray mechanism 133 (the incubation position may be a position of an incubation hole provided on the reaction inner tray mechanism 133, that is, which incubation hole of the reaction inner tray mechanism 133 the second reaction vessel is placed in), and the like. The second operation time may be a time required for the second reaction vessel to complete the incubation operation from the current position.

S230, respectively obtaining third operation time of each third reaction container from the current position to the position corresponding to the current target operation according to the test item information of the third reaction container; in particular, the current position of the third reaction vessel may be the washing device 14, and the third operation time may be a time required for the third reaction vessel to move from the washing device 14 to a reagent station corresponding to a reagent operation.

S240, respectively judging whether the time interval between the first operation time and the second operation time corresponding to more than one second reaction container is within a preset time; that is, whether the time interval between the first operation time and each of the second operation times is less than or equal to the preset time is respectively determined, wherein the preset time may be the operation time required for completing the current target operation.

S250, respectively judging that the time intervals of the first operation time and the third operation time corresponding to more than one third reaction container are within preset time; respectively judging whether the time interval between the first operation time and each third operation time is less than or equal to the preset time, wherein the preset time is the operation time required for completing the current target operation.

If the time interval between the first operation time and the second operation time corresponding to one or more second reaction vessels is within the preset time, and/or the time interval between the first operation time and the third operation time corresponding to one or more third reaction vessels is within the preset time, step S260 is performed to determine that the first reaction vessel, the second reaction vessel, and/or the third reaction vessel will perform the same target operation within the same time period.

If the time interval between the first operation time and the second operation time corresponding to any one of the second reaction vessels is greater than the preset time, and/or the time interval between the first operation time and the third operation time corresponding to any one third reaction vessel is more than the preset time, it is determined that the first reaction vessel does not interfere with the second reaction vessel and/or the third reaction vessel, at this time, step S270 may be performed, that is, it can be determined that the first reaction vessel does not interfere with the respective target operations of the second reaction vessel and the third reaction vessel, step S500 may be performed thereafter, the sample cup grasping mechanism 162 is controlled to transfer the first reaction vessel from the buffer tray mechanism 131 to the reaction tray mechanism, so that the first reaction vessel can be subjected to a reagent adding operation, an incubation operation, a washing operation, a detection operation, and the like according to the test items of the first reaction vessel.

Furthermore, the preset time may be 0, that is, if the first operation time is equal to the second operation time corresponding to one or more second reaction vessels, and/or the first operation time is equal to the third operation time corresponding to one or more third reaction vessels, it indicates that the first reaction vessel and the second reaction vessel and/or the third reaction vessel need to perform the same target operation at the same time, and it is determined that the first reaction vessel and the second reaction vessel and/or the third reaction vessel will perform the same target operation in the same time period.

In one embodiment, there may be a plurality of second reaction containers in the incubation operation on the reaction inner tray mechanism 133, and information on the total incubation time, the incubated time, and the remaining incubation time of each second reaction container can be obtained according to the test item information corresponding to each second reaction container. Since the total incubation time of the respective second reaction vessels may be different, when the second reaction vessel on the reaction tray mechanism completes the incubation operation, it is necessary to transfer the second reaction vessel having completed the incubation operation to the washing device 14 by the washing cup grasping mechanism 164 to perform the washing operation. Since only one cleaning cup-grasping mechanism 164 is provided in the chemiluminescent detector, resource calling conflict of cleaning cup-grasping mechanism 164 will occur when there are more than two second reaction vessels that have completed incubation operation at the same time and need to be transferred to cleaning apparatus 14 for cleaning operation.

In this embodiment, if the current target operation may be a washing transfer operation for transferring the reaction vessel having completed the incubation operation to the washing apparatus 14, the preset time may be a first preset time, which may be the time required for the washing cup-grasping mechanism 164 to transfer the second reaction vessel on the reaction disk mechanism to the washing apparatus 14. At this time, if the time interval between the first operation time and the second operation time corresponding to one or more second reaction vessels is less than or equal to a first preset time, it is determined that the first reaction vessel and the second reaction vessel will perform the cleaning transfer operation within the same time period. Wherein the first operation time is the time taken for the first reaction vessel to complete the incubation operation from the current position, that is, the first operation time is the sum of the time taken for the first reaction vessel to move from the current position to the reaction inner tray mechanism and the incubation time. The second operation time is a time taken for the second reaction vessel to complete the incubation operation from the current position to the second reaction vessel, i.e., the second operation time is a remaining incubation time of the second reaction vessel placed on the reaction inner tray mechanism, or a sum of a time taken for the second reaction vessel placed on the reaction outer tray mechanism to be transferred to the reaction inner tray mechanism and the incubation time. Specifically, as shown in fig. 6, when the target operation of each reaction vessel is the purge transfer operation, the above step S200 further includes:

s211, obtaining first operation time consumed by the first reaction container from the current position to the completion of the incubation operation according to the test item information of the first reaction container; specifically, the first operation time may be a time taken for the first reaction vessel to move from the buffer tray mechanism 131 to the reaction inner tray mechanism 133, and an incubation time on the reaction inner tray mechanism 133. Further, the time when the first reaction vessel completes the incubation operation can be predicted from the first operation time and the current time.

S221, obtaining second operation time consumed by the second reaction container from the current position to the completion of the incubation operation according to the test item information of the second reaction container; specifically, the second operation time may be the remaining incubation time of the second reaction vessel on the reaction inner tray mechanism 133, or the time taken for the second reaction vessel on the reaction outer tray mechanism 132 to move from the current position to the reaction inner tray mechanism 133, and the sum of the incubation times. Further, the time when the second reaction vessel completes the incubation operation can be predicted from the second operation time and the current time.

S241, respectively judging whether the time intervals of the first operation time and the second operation time corresponding to each second reaction container are within a first preset time; further, it may be determined whether a time interval between a time when the first reaction vessel completes the incubation operation and a time when each of the second reaction vessels completes the incubation operation is within a first preset time. The first preset time is an operation time taken for the cup grabbing mechanism 164 to complete the transfer of the reaction vessel from the reaction tray mechanism to the cleaning device 14, and may be 3 seconds, for example.

If the time interval between the first operation time and the second operation time corresponding to one or more second reaction vessels is within the first preset time, that is, if the time interval between the first operation time and the second operation time is less than or equal to the first preset time, step S261 is executed to determine that the first reaction vessel and the second reaction vessel will perform the cleaning transfer operation within the same time period. For example, if the time interval between the first operation time and the second operation time is 0.1 to 2.9 seconds, it is considered that the time interval between the first operation time and the second operation time is within the first preset time, and at this time, it is considered that the first reaction vessel will collide with the second reaction vessel in terms of time series, and the operation of transferring the first reaction vessel to the reaction outer tray mechanism 132 can be delayed. Further, if the first operation time and the second operation time are equal, that is, if the first reaction vessel and the second reaction vessel need to be transferred from the reaction tray mechanism 133 to the cleaning device 14 at the same time for the cleaning operation, step S261 is executed to determine that the first reaction vessel and the second reaction vessel will perform the cleaning transfer operation within the same time period.

Further, when the time intervals between the first operation time and the second operation time corresponding to each second reaction vessel are not within the preset time, that is, the time intervals between the first operation time and the second operation time corresponding to each second reaction vessel are greater than the first preset time, step S281 is executed to determine that the first reaction vessel and each second reaction vessel are not interfered with each other.

In one embodiment, if the current target operation may be a sample transfer operation for transferring the reaction container on the reaction outer tray mechanism to the buffer tray mechanism, the preset time may be a second preset time, which may be the time taken for the sample cup grabbing mechanism 162 to transfer the second reaction container on the reaction outer tray mechanism to the buffer tray mechanism 131. At this time, if the time interval between the first operation time and the second operation time corresponding to one or more second reaction vessels is less than or equal to the second preset time, it is determined that the first reaction vessel and the second reaction vessel will perform the sample transfer operation within the same time period. Wherein the first operation time is a time taken for the first reaction vessel to move from the current position to the transfer cup position on the peripheral side of the buffer tray mechanism. The second operation time is the time taken for the second reaction vessel to move from the current position to the cup adding station on the side of the reaction outer tray mechanism. Specifically, as shown in fig. 7, when the target operation of each reaction vessel is a sample transfer operation, the above step S200 further includes:

s212, obtaining a first operation time required by the first reaction container to move from the current position to the cup transferring position on the peripheral side of the buffer disc mechanism according to the test item information of the first reaction container.

And S222, obtaining second operation time consumed by the movement of each second reaction container from the current position to the cup processing station on the peripheral side of the reaction outer disc mechanism 132 according to the test item information of each second reaction container.

S242, respectively judging whether the time intervals of the first operation time and the second operation time corresponding to each second reaction container are within second preset time; here, the second preset time is an operation time taken for the sample cup-grasping mechanism 162 to complete the transfer of the reaction container from the reaction outer tray mechanism 132 to the buffer tray mechanism 131, and may be 3 seconds, for example.

If the time interval between the first operation time and the second operation time corresponding to one or more second reaction vessels is within the second preset time, that is, if the time interval between the first operation time and the second operation time is less than or equal to the second preset time, step S262 is performed to determine that the first reaction vessel and the second reaction vessel will perform the sample transfer operation within the same time period. For example, if the time interval between the first operation time and the second operation time is 0.1 to 2.9 seconds, the time interval between the first operation time and the second operation time may be considered to be within the second preset time, and at this time, the first reaction vessel may be considered to have a time-series conflict with the second reaction vessel, and the operation of transferring the first reaction vessel to the reaction outer tray mechanism 132 may be delayed. Further, if the first operation time and the second operation time are equal, that is, if the first reaction container and the second reaction container need to be moved at the same time by using the sample cup grasping mechanism 162, step S262 is executed to determine that the first reaction container and the second reaction container will perform the sample moving operation within the same time period.

Alternatively, if it is determined that the first reaction container and the second reaction container will perform the sample transfer operation within the same time period, the first reaction container on the buffer tray mechanism may be transferred to the reaction outer tray mechanism after delaying one cycle of the buffer tray movement. That is, if it is determined that the first reaction vessel and the second reaction vessel are to perform the sample transfer operation in the same time period, the sample catching mechanism is first controlled to transfer the second reaction vessel on the reaction outer tray mechanism to the idle loading hole on the buffer tray mechanism, and then the buffer tray mechanism is controlled to drive the first reaction vessel to rotate to the transfer cup position, so that the sample catching mechanism can transfer the first reaction vessel from the buffer outer tray mechanism to the reaction outer tray mechanism. The buffer tray movement cycle refers to the total time consumed for moving one loading hole 13111 on the buffer tray mechanism 131 from the current position to the target movement position, which may be a new cup loading position, a sample loading position, or a transfer cup position. For example, the buffer disc movement period may be 3 seconds.

Further, when the time intervals between the first operation time and the second operation time corresponding to each second reaction vessel are not within the preset time, that is, the time intervals between the first operation time and the second operation time corresponding to each second reaction vessel are greater than the second preset time, step S281 is executed to determine that the first reaction vessel and each second reaction vessel are not interfered with each other.

In one embodiment, there may be a plurality of second reaction containers in the incubation operation on the reaction inner tray mechanism 133, and information on the total incubation time, the incubated time, and the remaining incubation time of each second reaction container can be obtained according to the test item information corresponding to each second reaction container. Since the total incubation time of each second reaction vessel may be different, when the second reaction vessel on the reaction tray mechanism completes the incubation operation, it may be necessary to transfer the second reaction vessel having completed the incubation operation to the reaction outer tray mechanism through the incubation cup grasping mechanism to continue the reagent adding operation to the second reaction vessel having completed the incubation operation. The second reaction vessel that has completed the incubation operation may arrive at the same reagent station at the same time as the first reaction vessel on the buffer tray mechanism and need to use the same reagent adding mechanism for reagent addition operation, so that resource calling conflicts for the reagent adding mechanism will arise.

Therefore, the current target operation is a reagent adding operation, and the preset time may further include a third preset time, where the third preset time is an operation time required for completing the reagent adding operation. At this time, if the time interval between the first operation time and the second operation time corresponding to one or more second reaction vessels is within a third preset time, it is determined that the first reaction vessel and the second reaction vessel will perform the reagent adding operation within the same time period. Wherein, the first operation time is the time consumed by the first reaction container moving from the current position on the buffer disc mechanism 131 to the reagent adding station arranged on the peripheral side of the reaction disc mechanism; the second operation time is the time it takes for the second reaction vessel to move from the current position to the reagent addition station (which may include the time to move from the current position to the incubation position on the reaction inner tray mechanism, the total or remaining incubation time, and the time to move from the incubation position to the reagent addition station after completion of the incubation operation). As shown in fig. 8, the method further includes:

s213, obtaining a first operation time consumed by the first reaction container to move from the buffer disc mechanism 131 to a reagent adding station arranged on the peripheral side of the reaction disc mechanism according to the test item information of the first reaction container; specifically, when the first reaction vessel is a reaction vessel in an empty state, the first operation time may be the sum of the time taken for the first reaction vessel to transfer from the buffer tray mechanism 131 to the reaction outer tray mechanism 132 and the time taken for the first reaction vessel to move from the cup adding station corresponding to the reaction outer tray mechanism 132 to the reagent adding station. When the first reaction vessel is a reaction vessel containing a sample, the first operation time may further include a time consumed for a sample addition operation. Furthermore, the time at which the first reaction vessel moves to the reagent adding station can be predicted from the first operating time and the current time.

S223, obtaining second operation time consumed by the second reaction container to move to the reagent adding station according to the test item information of the second reaction container; specifically, the second operation time consumed by each second reaction vessel to move from the reaction disc mechanism to the reagent adding station can be obtained according to the test item information of each second reaction vessel on the reaction disc mechanism (including the reaction outer disc mechanism and the reaction inner disc mechanism). Alternatively, the second operation time may be the sum of the remaining time of the second reaction vessel for completing the incubation operation and the time taken to transfer from the reaction inner tray mechanism 133 to the reagent adding station on the reaction outer tray mechanism 132. Further, the time when each second reaction vessel moves to the reagent adding station can be predicted through the second operation time and the current time corresponding to each second reaction vessel on the reaction disk mechanism.

And S243, judging whether the time interval between the first operation time and each second operation time is within a third preset time. Further, it may be determined whether a time interval between a time when the first reaction vessel moves to the reagent adding station and a time when each of the second reaction vessels moves to the same reagent adding station is within a third preset time. Wherein the third preset time is the operation time required for completing the operation of adding the reagent. For example, the third preset time may be 3 seconds.

If the time interval between the first operation time and the second operation time corresponding to one or more second reaction vessels is within the third preset time, step S263 is executed to determine that the first reaction vessel and the second reaction vessel will perform reagent adding operation within the same time period. For example, if the time interval between the first operation time and the second operation time is 0.1 to 2.9 seconds, the time interval between the first operation time and the second operation time may be considered to be within the third preset time, and at this time, it may be considered that the first reaction vessel may collide with the second reaction vessel in terms of time sequence, and the operation of transferring the first reaction vessel to the reaction outer tray mechanism 132 may be delayed. Further, if the first operation time and the second operation time are equal, that is, when the first reaction vessel and the second reaction vessel reach the reagent adding station at the same time, step S263 is performed to determine that the first reaction vessel and the second reaction vessel will perform the reagent adding operation within the same time period.

Further, when the time intervals between the first operation time and the second operation time corresponding to each second reaction vessel are not within the third preset time, that is, the time intervals between the first operation time and the second operation time corresponding to each third reaction vessel are greater than the third preset time, step S281 is executed to determine that the first reaction vessel and each second reaction vessel are not interfered with each other.

In one embodiment, a third reaction vessel on the cleaning device 14 that is undergoing a cleaning operation may be transferred to the measuring device for a testing operation after the cleaning operation is completed. Alternatively, a third reaction vessel on the cleaning apparatus 14, on which a cleaning operation is being performed, may be transferred to the reaction outer tray mechanism 132 after completion of the cleaning operation, and a reagent adding operation or the like may be performed again. Therefore, if the current target operation is a reagent adding operation, the preset time may include a fourth preset time, where the fourth preset time is an operation time required for completing the reagent adding operation. At this time, if the time interval between the first operation time and the third operation time corresponding to one or more third reaction vessels is within the fourth preset time, it is determined that the first reaction vessel and the third reaction vessel will perform the reagent adding operation within the same time period. Wherein, the first operation time is the time consumed by the first reaction container moving from the current position on the buffer disc mechanism 131 to the reagent adding station arranged on the peripheral side of the reaction disc mechanism; the third operating time is the time it takes for the third reaction vessel to move from the current position on the washing device 14 to the reagent feeding station. Specifically, as shown in fig. 9, when the target operation of each reaction vessel is a reagent adding operation, the step S200 specifically includes:

s214, obtaining first operation time consumed by the first reaction container to move from the buffer disc mechanism 131 to a reagent adding station arranged on the peripheral side of the reaction disc mechanism according to the test item information of the first reaction container; specifically, when the first reaction vessel is a reaction vessel in an empty state, the first operation time may be the sum of the time taken for the first reaction vessel to transfer from the buffer tray mechanism 131 to the reaction outer tray mechanism 132 and the time taken for the first reaction vessel to move from the cup adding station corresponding to the reaction outer tray mechanism 132 to the reagent adding station. When the first reaction vessel is a reaction vessel containing a sample, the first operation time may further include a time consumed for a sample addition operation. Furthermore, the time at which the first reaction vessel moves to the reagent adding station can be predicted from the first operating time and the current time.

S231, obtaining third operation time consumed by the third reaction container to move to a reagent adding station according to the test item information of the third reaction container; specifically, the third operation time consumed for moving each third reaction vessel from the cleaning device 14 to the reagent feeding station can be obtained according to the test item information of each third reaction vessel on the cleaning device 14. Alternatively, the third operating time may be the sum of the remaining time for the third reaction vessel to complete the washing operation, the time taken to transfer from the washing apparatus 14 to the reaction outer tray mechanism 132, and the time taken to move from the washing and cup placing station to the reagent adding station. Furthermore, the time at which each third reaction vessel moves to the reagent adding station can be predicted by the third operating time and the current time corresponding to each third reaction vessel on the cleaning device 14.

And S251, judging whether the time interval between the first operation time and each third operation time is within a fourth preset time. Further, it may be determined whether a time interval between a time when the first reaction vessel moves to the reagent adding station and a time when each third reaction vessel moves to the same reagent adding station is within a fourth preset time. Wherein the fourth preset time is the operation time required for completing the operation of adding the reagent. For example, the fourth preset time may be 3 seconds.

If the time interval between the first operation time and the third operation time corresponding to one or more third reaction vessels is within the fourth preset time, step S264 is executed to determine that the first reaction vessel and the third reaction vessel will execute the reagent adding operation within the same time period. For example, if the time interval between the first operation time and the third operation time is 0.1 to 2.9 seconds, the time interval between the first operation time and the third operation time may be considered to be within the fourth preset time, and at this time, the first reaction vessel may be considered to have a time-series conflict with the third reaction vessel, and the operation of transferring the first reaction vessel to the reaction outer tray mechanism 132 may be delayed. Further, if the first operation time and the third operation time are equal, that is, when the first reaction vessel and the third reaction vessel reach the reagent adding station at the same time, step S264 is executed to determine that the first reaction vessel and the third reaction vessel will perform the same target operation within the same time period.

Further, when the time intervals between the first operation time and the third operation time corresponding to each third reaction vessel are not within the preset time, that is, the time intervals between the first operation time and the third operation time corresponding to each third reaction vessel are greater than the fourth preset time, step S282 is executed to determine that the first reaction vessel and each third reaction vessel are not interfered with each other.

It should be clear that, in conjunction with fig. 6 to 9, each step in fig. 6 and each step in fig. 9 may be performed simultaneously, each step in fig. 7 and each step in fig. 9 may be performed simultaneously, and each step in fig. 8 and each step in fig. 9 may be performed simultaneously. The step labels in the embodiment are only used for clearly describing the execution process of the method, and are not used for limiting the execution sequence.

Further, if steps S281 and S282 are satisfied simultaneously, it can be said that the first reaction vessel does not interfere with each of the second reaction vessels and/or each of the third reaction vessels, and then step S400 can be executed to control the sample cup grabbing mechanism 162 to transfer the first reaction vessel from the buffer tray mechanism 131 to the reaction tray mechanism, so that the first reaction vessel can be subjected to reagent adding operation, incubation operation, cleaning operation, detection operation, and the like according to the test item of the first reaction vessel.

Alternatively, as shown in fig. 5, the step S400 includes the following steps:

s410, the operation of transferring the first reaction vessel from the buffer tray mechanism 131 to the reaction tray mechanism is delayed by one or more buffer tray movement cycles until each target operation of the first reaction vessel does not interfere with each target operation of the second reaction vessel and the third reaction vessel. The buffer tray movement cycle refers to the total time consumed for moving one loading hole 13111 on the buffer tray mechanism 131 from the current position to the target movement position, which may be a new cup loading position, a sample loading position, or a transfer cup position. For example, the buffer disc movement period may be 3 seconds.

Further, as shown in fig. 5, the method further includes the following steps:

s600, judging whether the number of the motion cycles of the buffer disc which are delayed is larger than or equal to a preset threshold value. Furthermore, the value range of the preset threshold is 20-40, and the duration of each buffer disc motion period is 3 seconds. If the number of delayed buffer tray movement cycles is greater than or equal to the preset threshold, step S700 is executed to control the sample feeding mechanism 122 to pause the sample spitting operation or control the sample feeding mechanism 122 to delay the sample sucking operation.

It will be understood by those skilled in the art that all or part of the processes of the methods of the embodiments described above can be implemented by a computer program, which can be stored in a computer-readable storage medium, and when executed, can include the processes of the embodiments of the methods described above. Any reference to memory, storage, database, or other medium used in the embodiments provided herein may include non-volatile and/or volatile memory, among others. Non-volatile memory can include read-only memory (ROM), Programmable ROM (PROM), Electrically Programmable ROM (EPROM), Electrically Erasable Programmable ROM (EEPROM), or flash memory. Volatile memory can include Random Access Memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in a variety of forms such as Static RAM (SRAM), Dynamic RAM (DRAM), Synchronous DRAM (SDRAM), Double Data Rate SDRAM (DDRSDRAM), Enhanced SDRAM (ESDRAM), Synchronous Link DRAM (SLDRAM), Rambus Direct RAM (RDRAM), direct bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM).

Meanwhile, an embodiment of the present invention further provides a control system of a chemiluminescence detector, which includes a processor and a memory for storing a computer program, wherein the processor executes the method of any of the above embodiments when executing the computer program. In particular, the processor, when executing the computer program stored in the memory, performs the steps of:

the method comprises the steps of obtaining test item information of each reaction container on the chemiluminescence detector, wherein the test item information of each reaction container comprises a plurality of target operations required to be executed by the reaction container, operation time required for completing each target operation and current test operation of the reaction container, and obtaining information such as the current position of the reaction container according to the current test operation of the reaction container. For example, the test item information of each reaction container may include a plurality of target operations that the current sample needs to undergo to complete the entire test, such as a sample adding operation, a reagent adding operation, a mixing operation, an incubation operation, a washing and transferring operation, a washing operation, a testing operation, and the like. The test item information of each reaction vessel may further include an operation time taken to complete each target operation, a time required to move from a position corresponding to a current test operation to a position corresponding to a next target operation, and the like.

According to the test item information of each reaction container, respectively judging whether the first reaction container on the buffer tray mechanism 131 and a plurality of second reaction containers on the reaction tray mechanism are to execute the same target operation in the same time period; wherein the same time period may be an operation time required to complete the target operation. Specifically, the first reaction container may be a reaction container that needs to be transferred from the buffer tray mechanism 131 to the reaction tray mechanism, for example, the first reaction container may be a reaction container that has completed the sample adding operation, or the first reaction container may be a reaction cup that needs to be in an empty state for obtaining the target reagent from the reagent storage device.

Respectively judging whether the first reaction container on the buffer disc mechanism and each third reaction container on the cleaning device execute the same target operation in the same time period according to the test item information of each reaction container; wherein the same time period may be an operation time required to complete the target operation.

If the first reaction vessel and the one or more second reaction vessels and/or the one or more third reaction vessels execute the same target operation in the same time period, it indicates that there is a timing interference between the target operations of the first reaction vessel and the second reaction vessel and/or the third reaction vessel, the timing interference will cause a conflict of resource calling, and the execution of the transfer operation of transferring the first reaction vessel from the buffer tray mechanism 131 to the reaction tray mechanism is delayed, so as to avoid the timing conflict problem of the first reaction vessel and the second reaction vessel and/or the second reaction vessel.

Further, when the transfer operation of transferring the first reaction container from the buffer tray mechanism 131 to the reaction tray mechanism is delayed, it may be continuously determined whether there is a time-series conflict between the other first reaction containers on the buffer tray mechanism and the second reaction container and/or the third reaction container, and if there is a reaction container on the buffer tray mechanism that does not conflict with the second reaction container and/or the third reaction container, the reaction container without a conflict is preferentially transferred from the buffer tray mechanism to the reaction tray mechanism.

Further, when the transfer operation of transferring the first reaction container from the buffer tray mechanism 131 to the reaction tray mechanism is delayed, the sample application mechanism 122 may be simultaneously controlled to suspend the sample discharge operation, or the sample application mechanism 122 may be controlled to delay a period of time before the sample application operation. Therefore, the problems that the sample in the first reaction container is exposed for too long time, the detection result is inaccurate and the like can be avoided.

It should be clear that the working principle of the control system of this embodiment is substantially the same as the execution process of each step of the control method in the foregoing, and specific reference may be made to the description in the foregoing, and details are not described here.

In addition, as shown in fig. 10, an embodiment of the invention further provides a control system 900 of a chemiluminescence detector, which includes an obtaining module 910, a first determining module 920, a second determining module 930, and a control module 940. The obtaining module 910 is configured to obtain test item information of each reaction container on the chemiluminescence detector, where the test item information includes a plurality of target operations that the reaction container needs to execute and operation time required to complete each target operation. The first judging module 920 is configured to respectively judge whether the first reaction container on the buffer tray mechanism 131 and each second reaction container on the reaction tray mechanism will perform the same target operation in the same time period according to the test item information of each reaction container. The second determining module 930 determines whether the first reaction container on the buffer tray mechanism and each third reaction container on the cleaning device will perform the same target operation in the same time period according to the test item information of each reaction container. The control module 940 is configured to delay the execution of the operation of transferring the first reaction vessel from the buffer tray mechanism 131 to the reaction tray mechanism if the first reaction vessel and one or more second reaction vessels and/or one or more third reaction vessels are to execute the same target operation within the same time period.

It should be clear that the working principle of each module in the control system of this embodiment is substantially the same as the execution process of each step of the control method in the foregoing, and specific reference may be made to the description in the foregoing, and details are not described here again.

Furthermore, the invention also provides a chemiluminescence detector which comprises the control system. The chemiluminescence detector may further include a base 10, a reagent storage device 11, a dispensing device 12, a reaction device 13, a cleaning device 14, a measuring device 15, a cup grasping device 16, a reaction vessel conveying device 17, a consumable cartridge loading device 18, a sample conveying device 19, a mixing device, and the like, and the structures and the positional relationships of the above devices can be referred to the description above. The control system can be used for controlling the movement of each device, the automation degree and the detection accuracy of the chemiluminescence detector are improved, and the detection efficiency of the chemiluminescence detector is improved through the arrangement of the buffer disc mechanism.

According to the control method and system of the chemiluminescence detector and the chemiluminescence detector, whether the first reaction container on the buffer disc mechanism and each second reaction container on the reaction disc mechanism execute the same target operation in the same time period or not can be respectively judged according to the test item information of each reaction container, and whether the first reaction container on the buffer disc mechanism and each third reaction container on the cleaning device execute the same target operation in the same time period or not can be respectively judged; if it is determined that the first reaction vessel and the one or more second reaction vessels and/or the one or more third reaction vessels execute the same target operation within the same time period, it is determined that there is a time-series conflict between the first reaction vessel and the second reaction vessel and/or the one or more third reaction vessels, where the time-series conflict will result in a resource call conflict when the same target operation is completed, at this time, the operation of transferring the first reaction vessel from the buffer tray mechanism to the reaction tray mechanism may be performed with a delay to resolve the resource call conflict during the detection process, and further, other first reaction vessels on the buffer tray mechanism that do not have a time-series conflict with the second reaction vessel and/or the third reaction vessel may be transferred to the reaction tray mechanism, thereby improving the detection efficiency of the chemiluminescence detector.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. A control method of a chemiluminescence detector is characterized by comprising the following steps:

acquiring test item information of each reaction container on a chemiluminescence detector, wherein the test item information comprises a plurality of target operations to be executed by the reaction container and operation time required for completing each target operation; the chemiluminescence detector comprises a reaction device and a cleaning device; the reaction device comprises a buffer disc mechanism and a reaction disc mechanism; the cleaning device is used for removing impurities in the reaction vessel after incubation;

respectively judging whether a first reaction container on the buffer disc mechanism and each third reaction container on the cleaning device execute the same target operation in the same time period according to the test item information of each reaction container;

2. The method according to claim 1, wherein the step of determining whether the first reaction container on the buffer tray mechanism and the second reaction container on the reaction tray mechanism will perform the same target operation in the same time period according to the test item information of the reaction containers comprises:

3. The method according to claim 2, characterized in that the method further comprises the steps of:

4. The method according to claim 2 or 3, wherein the current target operation is a wash transfer operation of transferring the reaction vessel having completed the incubation operation to the washing device, the preset time comprising a first preset time, the method further comprising the steps of:

5. A method according to claim 2 or 3, wherein the current target operation is a sample transfer operation of transferring reaction vessels on the reaction outer tray mechanism to the buffer tray mechanism, the preset time comprising a second preset time, the method further comprising the steps of:

6. The method of claim 2 or 3, wherein the current target operation is a reagent addition operation, the preset time comprises a third preset time, and the method further comprises:

7. The method according to claim 1, wherein the step of determining whether the first reaction container on the buffer tray mechanism and each third reaction container on the cleaning device will perform the same target operation in the same time period based on the test item information of each of the reaction containers, respectively, further comprises:

8. The method of claim 7, further comprising the steps of:

9. The method of claim 7 or 8, wherein the current target operation is a reagent addition operation, the preset time comprises a fourth preset time, and the method further comprises:

10. The method of claim 1, wherein said delaying performing the transferring of the first reaction vessel from the buffer tray mechanism to the reaction tray mechanism comprises:

11. The method of claim 10, further comprising the steps of:

12. The method according to claim 11, wherein the preset threshold value ranges from 20 to 40, and the duration of each buffer disk movement period is 3 seconds.

13. The method of claim 10, further comprising the steps of:

14. A control system for a chemiluminescent detector comprising:

the system comprises an acquisition module, a detection module and a processing module, wherein the acquisition module is used for acquiring test item information of each reaction container on a chemiluminescence detector, and the test item information comprises a plurality of target operations required to be executed by the reaction container and operation time required for completing each target operation; the chemiluminescence detector comprises a reaction device and a cleaning device; the reaction device comprises a buffer disc mechanism and a reaction disc mechanism; the cleaning device is used for removing impurities in the reaction vessel after incubation;

15. A control system for a chemiluminescent detector comprising a processor and a memory for storing a computer program which, when executed by the processor, performs the method of any one of claims 1 to 13.

16. A chemiluminescent detection instrument comprising the control system of claim 14 or 15.

17. A computer-readable storage medium, in which a computer program is stored which, when being executed by a processor, carries out the steps of the method according to any one of claims 1 to 13.