CN109963935A - 用于采样流体流以监测连续流动中的污染物的方法 - Google Patents

用于采样流体流以监测连续流动中的污染物的方法 Download PDF

Info

Publication number
CN109963935A
CN109963935A CN201780069845.8A CN201780069845A CN109963935A CN 109963935 A CN109963935 A CN 109963935A CN 201780069845 A CN201780069845 A CN 201780069845A CN 109963935 A CN109963935 A CN 109963935A
Authority
CN
China
Prior art keywords
fluid stream
filter
product
pollutant
stream
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780069845.8A
Other languages
English (en)
Chinese (zh)
Inventor
P.施万
V.基斯特勒
M.洛贝丹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP16198334.1A external-priority patent/EP3141594A3/fr
Application filed by Bayer AG filed Critical Bayer AG
Publication of CN109963935A publication Critical patent/CN109963935A/zh
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12Purification
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/147Microfiltration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/20Accessories; Auxiliary operations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/58Multistep processes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04Filters; Permeable or porous membranes or plates, e.g. dialysis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02Filters
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06Investigating concentration of particle suspensions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2311/00Details relating to membrane separation process operations and control
    • B01D2311/26Further operations combined with membrane separation processes
    • B01D2311/2626Absorption or adsorption
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D36/00Filter circuits or combinations of filters with other separating devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/04Preparation or injection of sample to be analysed
    • G01N30/06Preparation
    • G01N30/14Preparation by elimination of some components

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Water Supply & Treatment (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201780069845.8A 2016-11-11 2017-11-03 用于采样流体流以监测连续流动中的污染物的方法 Pending CN109963935A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP16198334.1A EP3141594A3 (fr) 2016-11-11 2016-11-11 Procédé d'échantillonnage de flux de fluide permettant de surveiller des contaminants dans un écoulement continu
EP16198334.1 2016-11-11
EP17191961 2017-09-19
EP17191961.6 2017-09-19
PCT/EP2017/078143 WO2018086997A1 (fr) 2016-11-11 2017-11-03 Procédé d'échantillonnage de courants de fluide pour la surveillance de contaminants dans un flux continu

Publications (1)

Publication Number Publication Date
CN109963935A true CN109963935A (zh) 2019-07-02

Family

ID=60327296

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780069845.8A Pending CN109963935A (zh) 2016-11-11 2017-11-03 用于采样流体流以监测连续流动中的污染物的方法

Country Status (13)

Country Link
US (1) US20190359930A1 (fr)
EP (1) EP3538636A1 (fr)
JP (1) JP2019535260A (fr)
KR (1) KR20190079662A (fr)
CN (1) CN109963935A (fr)
AU (1) AU2017358509A1 (fr)
CA (1) CA3043294A1 (fr)
IL (1) IL266423A (fr)
MX (1) MX2019005567A (fr)
RU (1) RU2755065C2 (fr)
SG (2) SG11201903531UA (fr)
TW (1) TW201831889A (fr)
WO (1) WO2018086997A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110935274A (zh) * 2019-09-18 2020-03-31 赵兰坤 一种降低氨基酸发酵染菌的空气过滤装置

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210387146A1 (en) * 2020-06-11 2021-12-16 Duke University Collection of cells from biological fluid

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202047067U (zh) * 2010-12-13 2011-11-23 南宁庞博生物工程有限公司 生物酶液体和饮料的多级超滤纯化分离浓缩装置
CN104395341A (zh) * 2012-06-29 2015-03-04 Emd密理博公司 生物分子的纯化
WO2015133972A1 (fr) * 2014-03-07 2015-09-11 Agency For Science, Technology And Research Appareil et procédés permettant le fractionnement de produits biologiques
EP3015542A1 (fr) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Installation modulaire et procédé de production continue, présentant une réduction de germe et/ou préparation d'un produit
US20160230203A1 (en) * 2015-02-06 2016-08-11 Leidos, Inc. Portable Fluidic Platform For Rapid Cell-Free Production of Protein Biologics

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000319294A (ja) * 1999-05-11 2000-11-21 Asahi Chem Ind Co Ltd 生物由来高分子溶液精製方法
WO2006039588A2 (fr) * 2004-09-30 2006-04-13 Bayer Healthcare Llc Dispositifs et procedes de fabrication continue integree de molecules biologiques
US7981679B2 (en) * 2007-02-16 2011-07-19 Nalco Company Method of monitoring bulk (total) microbiological activity in process streams
WO2010058373A1 (fr) * 2008-11-24 2010-05-27 Koninklijke Philips Electronics N.V. Procédé et appareil pour analyse par filtre rapide d'échantillons fluides
CN103562145B (zh) * 2010-12-06 2016-09-21 颇尔公司 生物制品的连续加工方法
CA3204402A1 (fr) * 2012-03-26 2013-10-03 Sanofi Preparations d'anticorps igg4 stables anti-cxcr5
EP2914612B1 (fr) * 2012-10-30 2018-11-14 F.Hoffmann-La Roche Ag Purification de polypeptides au moyen de l'ultrafiltration d'écoulement tangentiel à double étage
US20160303258A1 (en) * 2013-12-03 2016-10-20 Millennium Pharmaceuticals, Inc. Compounds and compositions for imaging gcc-expressing cells

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202047067U (zh) * 2010-12-13 2011-11-23 南宁庞博生物工程有限公司 生物酶液体和饮料的多级超滤纯化分离浓缩装置
CN104395341A (zh) * 2012-06-29 2015-03-04 Emd密理博公司 生物分子的纯化
WO2015133972A1 (fr) * 2014-03-07 2015-09-11 Agency For Science, Technology And Research Appareil et procédés permettant le fractionnement de produits biologiques
US20160230203A1 (en) * 2015-02-06 2016-08-11 Leidos, Inc. Portable Fluidic Platform For Rapid Cell-Free Production of Protein Biologics
EP3015542A1 (fr) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Installation modulaire et procédé de production continue, présentant une réduction de germe et/ou préparation d'un produit

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110935274A (zh) * 2019-09-18 2020-03-31 赵兰坤 一种降低氨基酸发酵染菌的空气过滤装置

Also Published As

Publication number Publication date
SG10202104821SA (en) 2021-06-29
RU2755065C2 (ru) 2021-09-13
MX2019005567A (es) 2019-08-12
EP3538636A1 (fr) 2019-09-18
RU2019117905A3 (fr) 2021-03-10
KR20190079662A (ko) 2019-07-05
JP2019535260A (ja) 2019-12-12
IL266423A (en) 2019-06-30
AU2017358509A1 (en) 2019-05-09
US20190359930A1 (en) 2019-11-28
CA3043294A1 (fr) 2018-05-17
TW201831889A (zh) 2018-09-01
WO2018086997A1 (fr) 2018-05-17
RU2019117905A (ru) 2020-12-11
SG11201903531UA (en) 2019-05-30

Similar Documents

Publication Publication Date Title
CN105107228B (zh) 生物制品的连续加工方法
TWI679053B (zh) 自層析管柱中連續洗提產品之方法
CN102794109B (zh) 用于集成连续生产生物分子的装置和方法
US20220185868A1 (en) Bioreactor arrangement and continuous process for producing and capturing a biopol ymer
US20200318060A1 (en) System and method for the production of biomolecules such as viral vaccines
EP3015542A1 (fr) Installation modulaire et procédé de production continue, présentant une réduction de germe et/ou préparation d'un produit
US20180221823A1 (en) Re-Circulation Loop in CFF/TFF Single Use Path Flow
US20240150395A1 (en) Continuous production of recombinant proteins
CN109963935A (zh) 用于采样流体流以监测连续流动中的污染物的方法
CN103159824B (zh) 一种全封闭管路化的蛋白质纯化系统及其在无菌无热原蛋白质药物制备上的应用
EP3141594A2 (fr) Procédé d'échantillonnage de flux de fluide permettant de surveiller des contaminants dans un écoulement continu
DiBlasi et al. Disposable biopharmaceutical processes-myth or reality?
CN102191226A (zh) 细胞培养混合物的分离纯化方法
Chapman et al. Automated Multi-Stage Chromatographic Systems for Production of Biotherapeutics
Kelley et al. Virus removal by tangential-flow filtration for protein therapeutics
WO2023247798A1 (fr) Dispositif modulaire et procédé de fabrication continue de produits biotechnologiques
Priebe et al. Disposable Biopharmaceutical Processes–Myth or Reality?
SOFER et al. CLEANING AND SANITATION IN DOWNSTREAM PROCESSES

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40005824

Country of ref document: HK

WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20190702

WD01 Invention patent application deemed withdrawn after publication