CN109963935A - 用于采样流体流以监测连续流动中的污染物的方法 - Google Patents

用于采样流体流以监测连续流动中的污染物的方法 Download PDF

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Publication number
CN109963935A
CN109963935A CN201780069845.8A CN201780069845A CN109963935A CN 109963935 A CN109963935 A CN 109963935A CN 201780069845 A CN201780069845 A CN 201780069845A CN 109963935 A CN109963935 A CN 109963935A
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CN
China
Prior art keywords
fluid stream
filter
product
pollutant
stream
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201780069845.8A
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English (en)
Chinese (zh)
Inventor
P.施万
V.基斯特勒
M.洛贝丹
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Bayer AG
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Bayer AG
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Publication date
Priority claimed from EP16198334.1A external-priority patent/EP3141594A3/fr
Application filed by Bayer AG filed Critical Bayer AG
Publication of CN109963935A publication Critical patent/CN109963935A/zh
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12Purification
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/147Microfiltration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/20Accessories; Auxiliary operations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/58Multistep processes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04Filters; Permeable or porous membranes or plates, e.g. dialysis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02Filters
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06Investigating concentration of particle suspensions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2311/00Details relating to membrane separation process operations and control
    • B01D2311/26Further operations combined with membrane separation processes
    • B01D2311/2626Absorption or adsorption
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D36/00Filter circuits or combinations of filters with other separating devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/04Preparation or injection of sample to be analysed
    • G01N30/06Preparation
    • G01N30/14Preparation by elimination of some components

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Water Supply & Treatment (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
CN201780069845.8A 2016-11-11 2017-11-03 用于采样流体流以监测连续流动中的污染物的方法 Pending CN109963935A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP16198334.1A EP3141594A3 (fr) 2016-11-11 2016-11-11 Procédé d'échantillonnage de flux de fluide permettant de surveiller des contaminants dans un écoulement continu
EP16198334.1 2016-11-11
EP17191961.6 2017-09-19
EP17191961 2017-09-19
PCT/EP2017/078143 WO2018086997A1 (fr) 2016-11-11 2017-11-03 Procédé d'échantillonnage de courants de fluide pour la surveillance de contaminants dans un flux continu

Publications (1)

Publication Number Publication Date
CN109963935A true CN109963935A (zh) 2019-07-02

Family

ID=60327296

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780069845.8A Pending CN109963935A (zh) 2016-11-11 2017-11-03 用于采样流体流以监测连续流动中的污染物的方法

Country Status (13)

Country Link
US (1) US20190359930A1 (fr)
EP (1) EP3538636A1 (fr)
JP (1) JP2019535260A (fr)
KR (1) KR20190079662A (fr)
CN (1) CN109963935A (fr)
AU (1) AU2017358509A1 (fr)
CA (1) CA3043294A1 (fr)
IL (1) IL266423A (fr)
MX (1) MX2019005567A (fr)
RU (1) RU2755065C2 (fr)
SG (2) SG10202104821SA (fr)
TW (1) TW201831889A (fr)
WO (1) WO2018086997A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110935274A (zh) * 2019-09-18 2020-03-31 赵兰坤 一种降低氨基酸发酵染菌的空气过滤装置

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210387146A1 (en) * 2020-06-11 2021-12-16 Duke University Collection of cells from biological fluid

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202047067U (zh) * 2010-12-13 2011-11-23 南宁庞博生物工程有限公司 生物酶液体和饮料的多级超滤纯化分离浓缩装置
CN104395341A (zh) * 2012-06-29 2015-03-04 Emd密理博公司 生物分子的纯化
WO2015133972A1 (fr) * 2014-03-07 2015-09-11 Agency For Science, Technology And Research Appareil et procédés permettant le fractionnement de produits biologiques
EP3015542A1 (fr) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Installation modulaire et procédé de production continue, présentant une réduction de germe et/ou préparation d'un produit
US20160230203A1 (en) * 2015-02-06 2016-08-11 Leidos, Inc. Portable Fluidic Platform For Rapid Cell-Free Production of Protein Biologics

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JP2000319294A (ja) * 1999-05-11 2000-11-21 Asahi Chem Ind Co Ltd 生物由来高分子溶液精製方法
SI2550971T1 (sl) * 2004-09-30 2017-08-31 Bayer Healthcare Llc Naprave in postopki za integrirano kontinuirano izdelavo bioloških molekul
US7981679B2 (en) * 2007-02-16 2011-07-19 Nalco Company Method of monitoring bulk (total) microbiological activity in process streams
CN102224407B (zh) * 2008-11-24 2014-06-25 皇家飞利浦电子股份有限公司 用于对流体样本快速过滤分析的方法和仪器
CN105107228B (zh) * 2010-12-06 2017-03-29 颇尔公司 生物制品的连续加工方法
EP3431104A1 (fr) * 2012-03-26 2019-01-23 Sanofi Formulations d'agents de liaison igg4 stables
CN104755489B (zh) * 2012-10-30 2019-01-15 弗·哈夫曼-拉罗切有限公司 使用双级切线流超滤纯化多肽
JP2017503763A (ja) * 2013-12-03 2017-02-02 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. Gcc発現細胞を撮像するための化合物及び組成物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202047067U (zh) * 2010-12-13 2011-11-23 南宁庞博生物工程有限公司 生物酶液体和饮料的多级超滤纯化分离浓缩装置
CN104395341A (zh) * 2012-06-29 2015-03-04 Emd密理博公司 生物分子的纯化
WO2015133972A1 (fr) * 2014-03-07 2015-09-11 Agency For Science, Technology And Research Appareil et procédés permettant le fractionnement de produits biologiques
US20160230203A1 (en) * 2015-02-06 2016-08-11 Leidos, Inc. Portable Fluidic Platform For Rapid Cell-Free Production of Protein Biologics
EP3015542A1 (fr) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Installation modulaire et procédé de production continue, présentant une réduction de germe et/ou préparation d'un produit

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110935274A (zh) * 2019-09-18 2020-03-31 赵兰坤 一种降低氨基酸发酵染菌的空气过滤装置

Also Published As

Publication number Publication date
MX2019005567A (es) 2019-08-12
RU2019117905A3 (fr) 2021-03-10
WO2018086997A1 (fr) 2018-05-17
RU2755065C2 (ru) 2021-09-13
CA3043294A1 (fr) 2018-05-17
SG11201903531UA (en) 2019-05-30
US20190359930A1 (en) 2019-11-28
JP2019535260A (ja) 2019-12-12
IL266423A (en) 2019-06-30
EP3538636A1 (fr) 2019-09-18
TW201831889A (zh) 2018-09-01
AU2017358509A1 (en) 2019-05-09
KR20190079662A (ko) 2019-07-05
SG10202104821SA (en) 2021-06-29
RU2019117905A (ru) 2020-12-11

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