CN109846970A - It is a kind of for preventing and treating the compound nutritional promotor composition of diabetes - Google Patents
It is a kind of for preventing and treating the compound nutritional promotor composition of diabetes Download PDFInfo
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Abstract
The invention discloses a kind of compound nutritional promotor compositions for effectively controlling blood glucose He delaying complication.The composition is mainly by the material composition of following parts by weight: 0.002-0.1 parts of trivalent chromium, 1.35-65 parts of grape seed extract, 0.027-0.135 parts of thiamine, 0.027-0.135 parts of riboflavin, 0.027-0.135 parts of niacin, 0.027-0.135 parts of pyridoxine, 0.0027-0.0135 parts of biotin, 0.0027-0.0135 parts of folic acid, 1.35-65 parts of vitamin C, 0.67-33.5 parts of vitamin E, 0.027-0.135 parts of retinol etc..The present invention can increase glucose tolerance factor content, the sensibility for improving insulin, improve Insulin resistance, reduces blood glucose target, can be reduced insulin and hypoglycemic medicine usage amount, be the upgrading substitute of similar dietetic product.
Description
Technical field
It is specifically a kind of for preventing and treating the composite nutrient group of diabetes the present invention relates to medical control field
Close object.
Background technique
Diabetes (diabetes) are one group characterized by the horizontal raising of plasma glucose (blood glucose), by inherent cause and life
Chronic, the systemic metabolic disease of one kind caused by the long-term collective effect of environmental factor living.It is absolutely or opposite by insulin secretion
Insufficient and different degrees of insulin resistance leads to carbohydrate, fat, protein and water-electrolyte metabolism disorder, meeting
Cause the damages such as each organ especially eye, angiocarpy, the cerebrovascular, kidney, nerve, insufficiency, failure, leads to maimed or premature death one
Class disease.Be divided into according to difference the reason of morbidity there are four types of type, wherein type-2 diabetes mellitus be with the opposite secretion of beta Cell of islet not
Foot or insulin resistance be characterized, account for about diabetic population 90% or more." WHO Report " point out only 5%~
10% diabetes be the diabetes caused by insulin deficit, there are about 10% be in default of insulin receptor, and 80%~
85% diabetes are since glucose tolerance factor (GTF) lacks and impaired insulin action (also known as insulin resistance) causes
's.
Diabetes are the common disease of China's mid-aged population, high morbidity, and illness rate obviously increased in the past 20 years, according to 2013
Professional investigation statistics: diabetes prevalence and prediabetes illness rate are up to 9.7% and 15.7%, ten thousand He respectively more than 9,000
More than 100004000 ten thousand.One of have become one of four serious diseases of China's mid-aged population, and cause the big Death causes in China four.
Seriously endanger the health and life of China its people.Because pathoglycemia raising is the root for causing multiple complications, treatment
The core objective of diabetes first be control blood glucose target, especially because insulin action by obstacle (also known as insulin resistance or
Glucose tolerance factor lacks) caused by type-2 diabetes mellitus account for the 80-85% of type-2 diabetes mellitus pathogenic factor, medical market at present
There is insulin sensitizer, such as: Rosiglitazone, Pioglitazone, both drug category thiophenes applied to the drug for improving insulin resistance
Oxazolidinedione class antidiabetic, the sensibility by improving insulin efficiently control blood glucose, are to pass through peroxisome
The highly selective potent activator of Proliferation Activated Receptor γ (PPAR- γ) and play blood sugar reducing function.Do not improve glucose
Tolerance Factor (GTF) lacks phenomenon.Optimal insulin function improvement cannot be reached, while having one as chemical synthetic drug
Fixed toxic side effect and drug resistance.
Summary of the invention
The invention aims to provide a kind of can either effectively control blood glucose while also effectively delaying the compound of complication
Nutrient composition.
Technological means: the invention discloses it is a kind of for effectively control blood glucose and effectively delay various complication again safety
Compound nutritional promotor composition.The composition is mainly by the material composition of following parts by weight: trivalent chromium (Cr3+) 0.002-0.1
Part, 1.35-65 parts of grape seed extract, 0.027-0.135 parts of vitamin B1 (thiamine), vitamin B2 (riboflavin) 0.027-
0.135 part, 0.027-0.135 parts of vitamin B3 (niacin), 0.027-0.135 parts of vitamin B6 (pyridoxine), vitamin B7 (life
Object element) 0.0027-0.0135 parts, 0.0027-0.0135 parts of Vitamin B9 (folic acid), 1.35-65 parts of vitamin C, vitamin E
0.67-33.5 parts, 0.027-0.135 parts of vitamin A (retinol), 0.00013-0.0065 parts of vitamin D (Alfacalcidol),
0.027-0.135 parts of lutein, 0.67-33.5 parts of taurine, 0.54-27 parts of tea polyphenols, ubiquinone100.67-33.5 parts, sulphur it is pungent
2.7-80 parts of 1.35-65 parts sour, calcium (Ca), 0.13-6.5 parts of iron (Fe), 0.0008-0.004 parts of selenium (Se), zinc (En) 0.08-4
Part.
The common parts by weight of the main matter of the composition are as follows: 0.01-0.04 parts of trivalent chromium (Cr3+), grape pip extract
6.75-27 parts of object, 0.135-0.54 parts of vitamin B1 (thiamine), 0.135-0.54 parts of vitamin B2 (riboflavin), vitamin
0.135-0.54 parts of B3 (niacin), 0.4-1.3 parts of vitamin B6 (pyridoxine), vitamin B7 (biotin) 0.0135-0.054
Part, 0.0135-0.054 parts of Vitamin B9 (folic acid), 6.75-27 parts of vitamin C, 3.35-13.4 parts of vitamin E, vitamin A
0.135-0.54 parts of (retinol), 0.00065-0.0026 parts of vitamin D (Alfacalcidol), 0.135-0.54 parts of lutein,
3.35-13.4 parts of taurine, 2.7-10.8 parts of tea polyphenols, 3.35-13.4 parts of Co-Q10,6.75-27 parts of lipoic acid, calcium (Ca)
13.5-40 parts, 0.65-2.6 parts of iron (Fe), 0.004-0.016 parts of selenium (Se), 0.4-1.6 parts of zinc (En).
The preferred weight number of the main matter of the composition are as follows: 0.02 part of trivalent chromium (Cr3+), grape seed extract 14
Part, vitamin B10.3 part of (thiamine), vitamin B20.3 part of (riboflavin), vitamin B30.3 part of (niacin), vitamin B6(pyrrole
Tremble element) 0.3 part, vitamin B70.03 part of (biotin), vitamin B90.03 part of (folic acid), 14 parts of vitamin C, vitamin E 7
Part, 0.31 part of vitamin A (retinol), 0.002 part of vitamin D (Alfacalcidol), 0.3 part of lutein, 6.9 parts of taurine,
6 parts of tea polyphenols, ubiquinone106.9 parts, 14 parts of lipoic acid, 27 parts of calcium (Ca), 1.3 parts of iron (Fe), 0.008 part of selenium (Se), zinc (En)
1.0 part.
Beneficial effect, composite formula of the invention have effects that following:
Chromium ion (Cr) is the necessary microelement of human body, and " WHO Report " is pointed out: glucose tolerance factor
(GTF) the main reason for shortage or deficiency are type-2 diabetes mellitus, the 80-85% for accounting for type-2 diabetes mellitus pathogenic factor improve grape
It is effective main means for controlling blood glucose that sugared Tolerance Factor, which lacks, and GTF is by trace element chromium, niacin, glycine, cysteine
Deng at the soluble small molecular albumen being grouped as, each GTF molecule combines four chromium ions.Chromium ion be GTF it is important at
Divide and activating agent, GTF can effectively improve the sensibility of insulin, promote insulin in conjunction with C receptor, stimulate cell to glucose
Intake, inhibit resistance of the cell membrane to insulin, blood glucose level is effectively reduced.The chromium product of existing market application is mainly pyrrole
Pyridine Chroma-Pak, American scientist may make chromosome aberration the study found that organic pyridine ring can damage the DNA on chromosome.
The Chroma-Pak designed in the present invention is that the yeast chromium of biosynthesis, its biotic component compound avoid pyridine ring in pyridine chromium
Harm to human body is safer chromium articles.
Grape seed extract, also known as grape pip element, in grape pip it is main it is natural contain polyphenols-procyanidine,
It is played auxiliary with anti-oxidant, anti-cell aging effect by removing free radical and islet cells can be protected not damaged further
The effect for adjusting blood glucose is helped, and damaged cell can be repaired, prevents the occurrence and development process of diabetic complication.
Vitamin B1Also known as thiamine, be a kind of necessary vitamin fermentoid of human body, can not only to make starch etc. saccharide converted
The normal function of nerve cell can also be maintained at energy consumption, the pathological examination of diabetes is conversion ratio decline and the end of glucose
Tip neurotrosis, vitamin B1 can play beneficial effect in terms of the adjusting of blood glucose and maintenance nerve ending function.Vitamin
B1、B2、B6Equal proportion proportion can play maximum effect.
Vitamin B2, also known as riboflavin, be the necessary vitamin of human body, be the component part of internal yellow enzymes prothetic group, it is yellow
Enzyme plays in biological oxidation passs hydrogen effect, when lacking, just influences the biological oxidation of body, makes metabolism that obstacle occur.
Vitamin B2With promoting fat and breaks down proteins are energy, while also having the function of that ocular tissue and blood vessel, prevention is protected to move
Arteries and veins hardening.
Vitamin B3, also known as niacin, in vivo participate in sugar, fat, protein metabolic function, be converted into and spread out in human body
Biological niacinamide or niacinamide.Niacinamide is the component part of Coenzyme I and Coenzyme I I, by participating in sugar, lipid, albumen in vivo
Matter three is metabolized greatly, and tissue respiration oxidation process and the process of carbohydrate anaerobic decomposition is promoted to play the adjustment effect of blood glucose and blood lipid,
And improve blood circulation, facilitate the function of nerve cell.
Vitamin B6Also known as pyridoxine, be certain coenzyme in human body constituent, participate in a variety of metabolic responses, especially
There is substantial connection with amino acid metabolism.The function that more than 60 kinds of biological enzyme of body can be supported to bring into normal play, a function therein is just
It is the synthesis for promoting insulin, is the indispensable vitamin of diabetic.The activation pattern phosphoric acid ratio of vitamin B6 is trembled aldehyde
With protection vascular endothelial cell, the effect that endothelial cell is damaged by activated blood platelet is reduced, the effect of artery sclerosis is prevented.
Vitamin B7Also known as biotin, biotin, biotin are the coenzyme of a variety of enzymes in human body, participate in intracorporal fatty acid
With the metabolism of carbohydrate.Biotin participates in the fixation and carboxylation process of internal carbon dioxide in conjunction with enzyme, and intracorporal heavy
It wants metabolic process such as carboxylase and is transformed into oxaloacetic acid, acetyl coenzyme A carbonylation becomes the sugar such as malonyl coenzyme A and rouge
Main biochemical reaction in fat metabolism is related.Heteroplasia of the biotin for glycogen, the comprehensive function of fatty acid and certain amino
The metabolism of acid, is all a crucial regulation and control substance, and can be by helping the generation of energy to certain protein
Facilitation is played in synthesis；It simultaneously can helper cell growth, manufacture fatty acid, metabolism carbohydrate, fat and protein.
Vitamin B9Also known as folic acid is made of pteridine, p-aminobenzoic acid and Pidolidone, is also pteroylglutamic acid, leaf
Acid is necessary material of human body when using sugar and amino acid, substance necessary to being body cell growth and breeding.In body
Interior folic acid is worked in the form of tetrahydrofolic acid, and tetrahydrofolic acid participates in the synthesis of purine nucleic acid and pyrimidine nucleotide in vivo and turns
Change.
Vitamin C is also known as ascorbic acid, directly participates in hydroxylation reaction in vivo, and hydroxylation reaction is internal many important objects
Steps necessary matter synthesis or decomposed.Promote the biosynthesis of ossein.Conducive to the faster healing of tissue trauma mouth.Promote amino
The metabolism of tyrosine and tryptophan in acid, the physiological function of maintenance organization cell.Improve the metabolism of fat, particularly cholesterol,
Blood pressure and blood lipoid is promoted to adjust, prevention cardiovascular disease.
Vitamin E is also known as tocopherol, is the derivative of benzodihydropyran, is also important one of antioxidant.Energy
Enough effective anti-lipid peroxidations react, and the hydroxyl on the 6th carbon atom of vitamin E has active hydrogen atom, in body
Dehydrogenation during intracellular metabolite, restores organic free radical, due to its lipophilic structure, can be inserted into the presence of unsaturated fatty acid
Biomembrane in, rise cell membrane in antioxidation.In prevention and treatment cardiovascular and cerebrovascular disease, diabetes and other complication, maincenter mind
There is extensive effect through systemic disease etc..
Vitamin A is also known as retinol.Vitamin A is other than facilitating cell Proliferation and growth, main function
It is to maintain normal vision function, the photoreceptor of eye is rhabdocyte and cone cell in retina.Both cells are all deposited
There is photopigment, feeling the rhodopsin of dim light and the visual violet of the strong light of sense.Rhodopsin and visual violet are all by regarding
What albumen and retinene were constituted.Rhodopsin is after light irradiates, view of the 11-cis retinal isomery at trans-retinene, after separation
Yellow aldehyde is reduced to all-trans-retinal, is further transformed to trans- retinyl ester (or tautomerizing to cis-) and is stored in pigment epithelium
In.By retinyl ester hydrolase in retina, retinyl ester is changed into trans- retinol, through oxidation and isomerization, forms 11- along view
Yellow aldehyde.It is recombined with albumen again as rhodopsin, participates in the photochemical reaction of retina, restore the sensibility to dim light, prevented
Only yctalopia and hypopsia, one of common complication of diabetes are exactly retinopathy, and vitamin A facilitates to a variety of eyes
The prevention and treatment of disease.
Vitamin D is sterol analog derivative, has anti-rachitic effect, also known as antirachitic vitamin.Vitamin D family at
Most important member is VD2 (ergocalciferol) and VD3 (Vitamin D3) in member.Vitamin D can maintain Serum Calcium Phosphorus concentration
Stable and blood calcium concentration, while there is the intestinal absorption for promoting the minerals such as calcium phosphorus and promote the deposition of bone mineral, promote
Bone mineralizes, and constantly updates.Diabetes can cause osteoporosis quickening, and diabetic supplements enough vitamin Ds can
The occurrence and development of effective pre- anti-osteoporosis.
Lutein is also known as carotenoid, carotenol.Though being present in the nutrient of fruit and vegetables, absorption rate one
As it is lower, especially chronic patient or the middle-aged and the old need additional supplement.One of primary pigments ingredient of lutein retina, tool
Phototoxis is protected the eyes from, the aging of eyes is delayed and prevents lesion, while being also polyphenoils, trip can be resisted by having
Cell and organ damage are caused in human body from base, the diseases such as cardiovascula arteriosclerosis, coronary heart disease for thus preventing body aging to cause
Disease.
Taurine is also known as β-aminoethanesulfonic acid, is a kind of non-protein amino acid of sulfur-bearing.In vivo mainly with cystine, half
The metabolism of cystine is closely related.Taurine can bind to the insulin receptor, by interaction with insulin receptor protein,
Promote cellular uptake and utilize glucose, accelerates glycolysis, reduce blood sugar concentration.Taurine also has the life for promoting nervous system
Long development and cell Proliferation, differentiation, play an important role in cranial nerve cell growth course, also have to the anti-aging of nervous system
Certain effect.
Tea polyphenols are a kind of polyols contained in tealeaves, and main component is to have catechin and flavonoids.Tea is more
Phenol is metabolized important role to body fat.Cholesterol, the triglycerides equal size of human body are high, blood vessel fat deposition,
The cardiovascular diseases such as atheromatous plaque are formed after vascular smooth muscle cell curing.Youngster in tea polyphenols, especially tea polyphenols
Theine ECG and EGC and its oxidation product theaflavin etc. help to inhibit this plaque-like hyperplasia, make to form the enhancing of blood clotting viscosity
Fibrinogen reduces, and blood coagulation becomes clear, to inhibit atherosclerosis.The major complications of diabetes are exactly cardiovascular and cerebrovascular congee
Surprisingly occur caused by sample patch, tea polyphenols can play the role of energetically in terms of the prevention and treatment of diabetic complication.
Ubiquinone10Also known as ubiquinone belongs to quinones, is the auxiliary of three kinds of cyclophorases (multienzyme complex I, II and III)
One of enzyme and the big anti-aging substance of body seven, the nutrition of energy human activin cell and cellular energy, it is in cell mitochondrial
Energy conversion agent, can by shift and transmitting electronics participate in " tricarboxylic acid cycle " generate ATP (atriphos), i.e., energy because
Son is used for cell metabolism.Have the function of to improve the immunity of the human body, enhance anti-oxidant, anti-aging and enhancing human activity etc.,
And the method for being medically widely used in cardiovascular disease prevention, have to the prevention and treatment of the cardiovascular and cerebrovascular disease of diabetic complication
Positive effect.
Lipoic acid is a kind of coenzyme for being present in mitochondria, and similar vitamin, is strongest polyphenoils.Scientific research and
Clinic have been demonstrated to eliminate accelerated ageing and cause a diseaseFree radical.Lipoic acid enters cell after intestinal absorption in vivo, because of tool
Standby fat-soluble and water-soluble characteristic, therefore any one of body cell area can be reached, it is comprehensively anti-oxidant to provide human body
Efficiency is that have fat-soluble and water-soluble universal antioxidant.Lipoic acid is anti-in two critical oxidative deaminations as coenzyme
Work in answering, i.e., in pyruvate dehydrogenase complex and ketoglurate dehydrogenase complex, the generation of catalyzing acyl and
Transfer.Lipoic acid can receive the acetyl group of acyl group and pyruvic acid, form a thioester bond, then by acetyl grouptransfer to coenzyme
On the sulphur atom of A molecule.The dihydrolipoamide for forming prothetic group can be aoxidized through dihydrolipoamide dehydrogenase (needing NAD) again,
Regenerate oxidized form lipoamide.Alpha-lipoic acid contains double sulphur five-membered ring structures, and electron density is very high, has significant electrophilic
Sub- property and the ability with radical reaction, therefore it has inoxidizability, with high healthcare function and medical value (as resisted
Fatty liver and the effect for reducing plasma cholesterol).Diabetic be the free radicals such as lipid peroxide accumulate excessive posture,
Easily cause cell senescence acceleration, atherosclerosis acceleration, the antioxidation of lipoic acid has product in terms of diabetes control
Polar region effect, in addition, lipoic acid can also prevent sugar with protein combineing with, the effect of performance " anti-saccharification ", therefore can allow blood glucose
Value becomes stable and blood glucose value stabilization effect easily.
Calcium (Ca) calcium is that people's in-vivo content is most.The 1.5% to 2% of the calcareous weight for probably accounting for people, wherein 99% deposits
It is bone, tooth main composition in bone and tooth.1% is present in blood plasma, interstitial fluid and soft tissue, keeps
The normal of blood calcium concentration is used to maintaining human normal vital movement to play to closing recast, and human body will appear nerve conduction resistance when calcium deficiency
The symptoms such as stagnant and dystonia.Calcium ion plays an important role to the adhesion of cell, the maintenance of cell membrane function.Cell membrane is both
The barrier of cellular content, even more various required nutriments and oxygen enter the carrier of cell.The calcium ion energy of normal contents
Guarantee cell membrane successfully nutriment " pump " into the cell.Calcium ion has activation to the intracorporal enzyme reaction of people.Everybody
It both knows about, enzyme is the catalyst of the various substance metabolism process of human body, is a kind of important living matter of human body, calcium deficiency i.e. can shadow
Ring normal physiological metabolism process.Calcium ion has decisive role to the secretion of human endocrine glandular hormone, to maintenance circulation, exhales
The function of the system organs such as suction, digestion, uropoiesis, nerve, endocrine, reproduction is most important.In short, calcium is that human body is indispensable
Macroelement.Diabetic can cause the loss of skeleton nutrition to accelerate, and osteoporosis aggravates.Calcium is that China resident generally lacks
Weary nutrient, especially to chronic, calcium ion, which is replenished in time, facilitates the stabilization and reparation of disease.
Iron (Fe) is micronutrients needed by human, that content is most, and intracorporal ferro element can be divided into function by its function
It can iron nand function storage iron two parts.Function iron accounts for the 70% of internal iron total amount, is mainly present in blood with blood red prime form
In Lactoferrin, myoglobins, neuroglobin, ferroheme enzyme, confactor etc., therefore our ferrohemes are referred to as the function of human body
Iron.Non-functional stores iron, then is mainly present in liver, spleen and marrow in the form of ferritin and hemosiderin, is commonly called as body
Interior iron warehouse.Function iron participates in hemoglobin, myoglobins, neuroglobin and DNA synthesis and cellular energy metabolism in vivo
Etc. important physiology course.Function iron also participates in the composition of iron enzyme, promotes catalase, peroxidase, monoamine oxidase
Equal iron rely on the activity of enzyme, to influence human body cell energetic supersession.Function asiderosis, human body cell energetic supersession just cannot be just
Often carry out.Diabetes are metabolic diseases, and supplementary functions iron facilitates the stabilization and reparation of disease.
Selenium (Se) selenium is the essential trace elements of the human body, and selenium is the activation of internal glutathione peroxidase (GSH--PX)
Agent, since GSH--PX has protection cell membrane integrity in vivo, eliminates free radical, in reinforcement the effects of immune function, thus
Play the role of preventing and curing diseases.A large amount of free radical (oxide) is generated in diabetic's body, is directly encroached on human body cell, is led
It causes human senility to accelerate, especially causes blood vessel endothelium inflammatory damage, accelerate atheromatous plaque deposition, selenium element passes through activation gluathione
Peptide peroxidase function, is beneficial to the deposition removing interior free yl, repair blood vessel endothelium inflammatory damage, reducing Lipid Plaque
Prevent cardiovascular and cerebrovascular diseases complication to occur.
Zinc (En) zinc is one of the essential trace elements of the human body, in growth in humans's development, reproduction heredity, immune, endocrine
Etc. playing an important role in important physiology course, Zn-ef ficiency is present in numerous enzyme systems, such as carbonic anhydrase, breathing
It is nucleic acid, protein, carbon water during enzyme, lactic acid dehydroacid, superoxide dismutase, alkaline phosphatase, DNA and RNA are poly- in enzyme etc.
The necessary material that the synthesis of compound and vitamin A utilize.The immunity of diabetic is decreased obviously, and Zn-ef ficiency is immune device
Thymus development can be just effectively ensured by zinc amount abundance in the nutrient of official's thymus development, and normal differentiation T lymphocyte promotes thin
Born of the same parents' immune function, the raising to diabetes patient's immunity, the enhancing of anti-infection ability have effect.
Compound nutritional promotor composition provided by the present invention can be made various oral according to the conventional pharmaceutical method of pharmacy
Preparation, such as tablet, capsule.
The present invention provides a kind of for curative effect, the tablet formulation method of safety observations:
Each ingredient alternative condition of compound nutritional promotor composition of the invention preferred weight part ratio as described above weighs
Each component.
By yeast chromium (trivalent chromium compound), grape seed extract, vitamin B1, vitamin B2, vitamin B3(niacin),
Vitamin B6, vitamin B7(biotin), vitamin B9(folic acid), vitamin C, vitamin E, vitamin A, vitamin D, leaf are yellow
Element, taurine, tea polyphenols, ubiquinone10, lipoic acid, calcium (Ca), iron (Fe), selenium (Se), 21 kinds of ingredients such as zinc (En) are by preferred weight
Amount part than a certain number of excipient of addition after evenly mixing, again tabletting form.Tablet dispensers are made by 1 gram of a standard to enter
Bottle sealing saves backup after ultraviolet disinfection is handled.Every standard includes as 21 kinds of 718.62 milligrams of component contents, excipient
281.38 milligrams of content.
The present invention is prepared into the usage and dosage after tablet are as follows: 1 tablet once by adult, takes daily 2 times, half an hour before early, supper
It takes；1 month is an observation course for the treatment of.
Compound nutritional promotor composition provided by the present invention shows that it usually takes the patient of diabetes by clinical observation
After 1 course for the treatment of of compound nutritional promotor composition of the present invention, the blood glucose of type-2 diabetes mellitus can decline 10%-30%, early diabetes are suffered from
Person can be controlled within normal range (NR), and clinical symptoms are all effectively improved.
Compound nutritional promotor composition provided by the present invention can control the blood glucose level of type 2 diabetes patient well,
And the clinical symptoms of diabetic complication can be effectively improved.Therefore it cannot be only used for treatment type-2 diabetes mellitus, while can be with
For treating diabetic complication, such as diabetes complicated cardiovascular and cerebrovascular ischemic conditions, diabetic nephropathy, diabetic foot, sugar
Urinate sick neuropathy, diabetic eye diseases, diabetic skin pruritus etc..
Compound nutritional promotor composition of the invention passes through the blood sugar test statistical result showed to 50 cases observed: drop
Case of the sugar effect higher than 10% accounts for 88%.Case of the blood sugar reducing function lower than 10% accounts for 12%.More drinks, more foods, diuresis, it is tired,
The symptoms improvement rate such as syntexis accounts for 82%.It is not found during observation relevant to each ingredient of compound nutritional promotor composition of the invention
Adverse reaction.
The present invention is described in further detail below by way of specific implementation case:
Referring to the Ministry of Public Health " guideline of clinical investigations of new Chinese medicine treatment diabete diabetes " diagnostic criteria in 1993: on an empty stomach
Blood glucose (FBG) >=7.0mmol/L is included in selected case；Selection case 50.
Observation project: 1 fasting blood-glucose (FBG) of measurement in every 3 days.
Efficacy assessment standard:
Referring to the criterion of therapeutical effect evaluation in the Ministry of Public Health " guideline of clinical investigations of new Chinese medicine treatment diabete diabetes "；
It is effective: 20% or more decline before FBG < 7.0mmol/L or FBG are relatively treated；It is effective: FBG < 8.0mmol/L or FBG compared with
10% or more decline before treatment；Invalid: blood glucose decline does not reach above-mentioned standard before relatively treating.
Table one is composition disclosed by the invention with above-mentioned preferred substance weight component yeast chromium (by chromium metering)
0.02 part, 14 parts of grape seed extract, vitamin B10.3 part, vitamin B20.3 part, vitamin B30.3 part of (niacin), dimension life
Plain B60.3 part, vitamin B70.03 part of (biotin), vitamin B90.03 part of (folic acid), 14 parts of vitamin C, vitamin E 7
Part, 0.31 part of vitamin A, 0.002 part of vitamin D, 0.3 part of lutein, 6.9 parts of taurine, 6 parts of tea polyphenols, ubiquinone10
6.9 parts, 14 parts of lipoic acid, 27 parts of calcium (Ca), 1.3 parts of iron (Fe), 0.008 part of selenium (Se), 1.0 parts of zinc (En)] configuration experiment
Sample was to treating diabetes one month fasting blood-glucose effect observation statistical form.
The effect observation statistical form of table a pair of diabetes fasting blood-glucose
As seen from the table, this composition is average to the hypoglycemic rate of impaired fasting glucose 20.1%.
Be statistically analyzed: P < 0.01 has apparent statistical significance.
Table two is for composition disclosed by the invention with the laboratory sample of above-mentioned preferred substance weight component configuration to glycosuria
Disease treats one month efficient statistical form of effect observation.
Effect observation effective percentage statistical form of the table two to diabetes fasting blood-glucose
Be statistically analyzed: P < 0.01 has apparent statistical significance.
Table three is for composition disclosed by the invention with the laboratory sample of above-mentioned preferred substance weight component configuration to glycosuria
Disease treats the statistical form of one month fasting blood-glucose index observing.
Statistical form of the table three to diabetes fasting blood-glucose index observing
Be statistically analyzed: P < 0.01 has apparent statistical significance.
Illustrate the present invention in the beneficial effect for the treatment of diabetes below by way of some experimental examples；
Experimental example 1
Mrs Lin, 59 years old, Guangzhou was lived in ancestral home Heilungkiang.Pensioner.Figure is more fat, type-2 diabetes mellitus treatment in 12 years
History is accompanied with coronary heart disease, cerebral ischemia illness in nearly 4 years successively, and clinical symptoms are obvious.Successively took melbine, Glipizide,
Rosiglitazone takes always three kinds of melbine, Rosiglitazone antidiabetic drug drugs for diabetes problem in nearly 1 year.Inspection before experiment
Survey fasting blood-glucose (FBG) 7.8mmol/L；It is added by the test specimen that composition of the invention configures, 2 times a day, enjoins every three
It does a fasting blood-glucose from surveying, and starts fasting blood-glucose after two weeks and downward trend day by day occurs, consciously slight more drinks, more foods,
The symptoms such as diuresis, dizziness, out of strength, palpitaition, shortness of breath make moderate progress, and Guangzhou medical university second is attached after the completion of one month course for the treatment of
Hospital checks fasting blood-glucose 6.3mmol/L；The symptoms such as conscious dizzy, out of strength, palpitaition, shortness of breath further improve.
Experimental example 2
Mrs Li, 47 years old, Guangzhou was lived in ancestral home Zhanjiang.Teacher.Figure is partially fat, there is Diabetes family history, finds blood glucose rise
It 5 years, is checked through hospital and is diagnosed as type-2 diabetes mellitus.The prescription doctor's advice control sugar formulated for the first time by hospital, it is double to take always diformazan
Guanidine and Glipizide, it is easily hungry, easily thirsty, have weak sense.The above 10 Tian Hou hospital of antidiabetic drug is deactivated before experiment checks fasting blood-glucose
(FBG)8.1mmol/L.It is added by the test specimen that composition of the invention configures, 2 times a day, instrucion does primary sky every three days
Abdomen blood glucose self monitoring is begun to decline from the fasting blood-glucose surveyed after a week, and blood glucose also gradually reduces as time goes by, easily starve, is easily thirsty,
The symptom of diuresis also gradually mitigates, and hospital's review result: fasting blood-glucose (FBG) 6.5mmol/L is arrived after one month course for the treatment of,
It easily starves, easily thirsty, diuresis, symptom out of strength are also obviously improved.
Experimental example 3
Mr. Zhang, 52 years old, people from city, Guangzhou Guangdong.Figure is more fat, and for many years, symptom is unobvious, so not having always for discovery pathoglycemia
Useful drug is controlled, and hospital checks fasting blood-glucose (FBG) 7.9mmol/L before testing.It is configured by composition of the invention
Test specimen is taken, 2 times a day, instrucion do every three days a fasting blood-glucose from survey, after a week from survey fasting blood-glucose under
Drop, blood glucose also gradually reduces as time goes by, and hospital's review result: fasting blood-glucose (FBG) is arrived after one month course for the treatment of
6.1mmol/L。
It can be seen that in 50 patients from above-mentioned one group of table, effective person has 4, and responder has 17, and obvious effective rate is
42%, effective percentage is 46%, total effective rate 88%.
In conclusion present invention employs the essential trace elements of the human body chromium (trivalent chromium) to have obvious function of polysaccharide simultaneously
Compatibility other promote islet cells reparations, improve insulin function grape pip element, vitamin B3(niacin), vitamin B6Nutrition
Element, the yeast chromium of application can avoid the risk of the pyridine ring damage human body chromosome of pyridine chromium.The vitamin that the present invention applies
B1, vitamin B2, vitamin B3(niacin), vitamin B6, vitamin B7(biotin), vitamin B9(folic acid), vitamin C, dimension
Raw element E, vitamin A, vitamin D, lutein, taurine, calcium, iron, zinc are a variety of vitamins needed by human and nutrient, go back
The occurrence and development that repair is played to the histocyte of diabetic lesions, facilitates prevention complication.The tea that the present invention applies
Polyphenol proof helps to inhibit atheromatous plaque shape hyperplasia, to inhibit atherosclerosis, in the prevention and treatment of diabetic complication
Aspect can play the role of energetically.The ubiquinone that the present invention applies10With improve the immunity of the human body, enhance it is anti-oxidant, delay senescence
With the enhancing functions such as human activity, play the role of to the prevention and treatment of the cardiovascular and cerebrovascular disease of diabetic complication positive.The present invention answers
Lipoic acid, selenium element are extremely strong antioxidants, can not only eliminate accelerated ageing and cause a diseaseFree radical, enhance human body and exempt from
Epidemic disease function, moreover it is possible to repair blood vessel endothelium inflammatory damage, the deposition for reducing Lipid Plaque, be beneficial to prevent cardiovascular and cerebrovascular diseases complication
Occur.The present invention by increase insulin sensibility, improve Insulin resistance and necessary nutrient supplement, can be effective
Prevent and treat diabetes and diabetic complication, inhibit the pathological development of cardio-cerebrovascular disease, reduce diabetes incidence,
Disability rate and the death rate, substitution or the usage amount for reducing insulin and hypoglycemic medicine are reduced secondary using chemicals bring poison
Effect and drug resistance generate, and are the supplement of chemicals and the upgrading substitute of similar dietetic product.
Specific embodiment
Embodiment 1: the invention discloses it is a kind of for effectively control blood glucose and effectively delay various complication again safety
Compound nutritional promotor composition.The composition is mainly by the material composition of following parts by weight: trivalent chromium (Cr3+) 0.002-0.1
Part, 1.35-65 parts of grape seed extract, 0.027-0.135 parts of vitamin B1,0.027-0.135 parts of vitamin B2, vitamin
0.027-0.135 parts of B3 (niacin), 0.027-0.135 parts of vitamin B6,0.0027-0.0135 parts of vitamin B7 (biotin),
0.0027-0.0135 parts of Vitamin B9 (folic acid), 1.35-65 parts of vitamin C, 0.67-33.5 parts of vitamin E, vitamin A
0.027-0.135 parts, 0.00013-0.0065 parts of vitamin D, 0.027-0.135 parts of lutein, 0.67-33.5 parts of taurine,
0.54-27 parts of tea polyphenols, ubiquinone100.67-33.5 parts, 1.35-65 parts of lipoic acid, 2.7-80 parts of calcium (Ca), iron (Fe) 0.13-
6.5 parts, 0.0008-0.004 parts of selenium (Se), 0.08-4 parts of zinc (En).
Embodiment 2: the invention discloses it is a kind of for effectively control blood glucose and effectively delay various complication again safety
Compound nutritional promotor composition.The common parts by weight of the main matter of the composition are as follows: 0.01-0.04 parts of trivalent chromium (Cr3+),
6.75-27 parts of grape seed extract, 0.135-0.54 parts of vitamin B1,0.135-0.54 parts of vitamin B2, vitamin B3 (cigarette
Acid) 0.135-0.54 parts, 0.4-1.3 parts of vitamin B6,0.0135-0.054 parts of vitamin B7 (biotin), Vitamin B9 (leaf
Acid) 0.0135-0.054 parts, 6.75-27 parts of vitamin C, 3.35-13.4 parts of vitamin E, 0.135-0.54 parts of vitamin A,
0.00065-0.0026 parts of vitamin D, 0.135-0.54 parts of lutein, 3.35-13.4 parts of taurine, tea polyphenols 2.7-10.8
Part, 3.35-13.4 parts of Co-Q10,6.75-27 parts of lipoic acid, 13.5-40 parts of calcium (Ca), 0.65-2.6 parts of iron (Fe), selenium
(Se) 0.004-0.016 parts, 0.4-1.6 parts of zinc (En).
Embodiment 3: the invention discloses it is a kind of for effectively control blood glucose and effectively delay various complication again safety
Compound nutritional promotor composition.The preferred weight number of the main matter of the composition are as follows: 0.02 part of trivalent chromium (Cr3+), grape pip
14 parts of extract, vitamin B10.3 part, vitamin B20.3 part, vitamin B30.3 part of (niacin), vitamin B60.3 part, dimension
Raw element B70.03 part of (biotin), vitamin B90.03 part of (folic acid), 14 parts of vitamin C, 7 parts of vitamin E, vitamin A
0.31 part, 0.002 part of vitamin D, 0.3 part of lutein, 6.9 parts of taurine, 6 parts of tea polyphenols, ubiquinone106.9 parts, lipoic acid
14 parts, 27 parts of calcium (Ca), 1.3 parts of iron (Fe), 0.008 part of selenium (Se), 1.0 parts of zinc (En).
Claims (3)
1. a kind of oral preparation, it is characterised in that, the ingredient of the oral preparation include the substance of following components by weight percent:
0.002-0.1 parts of trivalent chromium (Cr3+), 1.35-65 parts of grape seed extract, 0.027-0.135 parts of vitamin B1, dimension life
Plain B2 0.027-0.135 parts, 0.027-0.135 parts of vitamin B3 (niacin), 0.027-0.135 parts of vitamin B6, vitamin
0.0027-0.0135 parts of B7 (biotin), 0.0027-0.0135 parts of Vitamin B9 (folic acid), 1.35-65 parts of vitamin C, dimension
Raw 0.67-33.5 parts of element E, 0.027-0.135 parts of vitamin A, 0.00013-0.0065 parts of vitamin D, lutein 0.027-
0.135 part, 0.67-33.5 parts of taurine, 0.54-27 parts of tea polyphenols, 0.67-33.5 parts of Co-Q10, lipoic acid 1.35-65
Part, 2.7-80 parts of calcium (Ca), 0.13-6.5 parts of iron (Fe), 0.0008-0.004 parts of selenium (Se), 0.08-4 parts of zinc (En).
2. oral preparation according to claim 1, it is characterised in that, the ingredient of the oral preparation include following weight group
The substance divided:
0.01-0.04 parts of trivalent chromium (Cr3+), 6.75-27 parts of grape seed extract, 0.135-0.54 parts of vitamin B1, dimension life
Plain B2 0.135-0.54 parts, 0.135-0.54 parts of vitamin B3 (niacin), 0.4-1.3 parts of vitamin B6, vitamin B7 (biology
Element) 0.0135-0.054 parts, 0.0135-0.054 parts of Vitamin B9 (folic acid), 6.75-27 parts of vitamin C, vitamin E
3.35-13.4 parts, 0.135-0.54 parts of vitamin A, 0.00065-0.0026 parts of vitamin D, 0.135-0.54 parts of lutein,
3.35-13.4 parts of taurine, 2.7-10.8 parts of tea polyphenols, 3.35-13.4 parts of Co-Q10,6.75-27 parts of lipoic acid, calcium (Ca)
13.5-40 parts, 0.65-2.6 parts of iron (Fe), 0.004-0.016 parts of selenium (Se), 0.4-1.6 parts of zinc (En).
3. according to claim 1, the organic compound containing trivalent chromium still includes nicotinate chromium, glutamic acid other than yeast chromium
Chromium, chromium methionine, the biosynthesis class such as glycine chromium contain chromium compound.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115702933A (en) * | 2021-08-09 | 2023-02-17 | 深圳奥萨制药有限公司 | Composition for assisting in reducing blood glucose |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115702933A (en) * | 2021-08-09 | 2023-02-17 | 深圳奥萨制药有限公司 | Composition for assisting in reducing blood glucose |
| CN115702933B (en) * | 2021-08-09 | 2024-04-16 | 深圳奥萨制药有限公司 | Composition for assisting in reducing blood sugar |
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