CN105054065B - A kind of antioxidant composition and its application, health food - Google Patents
A kind of antioxidant composition and its application, health food Download PDFInfo
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- CN105054065B CN105054065B CN201510510865.7A CN201510510865A CN105054065B CN 105054065 B CN105054065 B CN 105054065B CN 201510510865 A CN201510510865 A CN 201510510865A CN 105054065 B CN105054065 B CN 105054065B
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- vitamin
- composition
- enriched yeast
- health food
- muskmelon
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention relates to technical field of health care food, more particularly to a kind of antioxidant composition and its application, health food.Said composition includes muskmelon extract, vitamin E and Se-enriched yeast.After the present invention is by the way that muskmelon extract, vitamin E and Se-enriched yeast are used cooperatively, in the case where greatly reducing each component dosage, composition provided by the invention is remarkably improved SOD vigor and GSH contents, generates obvious synergistic function, has significant anti-oxidation efficacy.
Description
Technical field
The present invention relates to technical field of health care food, more particularly to a kind of antioxidant composition and its application, health food.
Background technology
Aging be biology over time, spontaneous necessary process, it is complicated natural phenomena, shows as structure
And hypofunction, adaptability and resistance decline.People why can one of gradual aging, its reason be body carry out it is a series of
While oxidative metabolism, free radical is constantly be generated, superfluous free radical may act on the lipid materials such as blood, cell, tissue,
It is set to become MDA, these peroxide are deposited on cell membrane, are made cell membrane loss of function, are caused cell viability
Decline, tissue organ function's decline, body enters aging state.These oxides are also deposited on vascular wall, cause blood vessel hard
Change, easily produce angiorrhoxis.Superfluous free radical can also act on intracellular hereditary material DNA, make cell carcinogenesis or dead
Die.
The antioxidation of body can keep the generation of free radical and the balance eliminated, have to prevention disease and anti-ageing wait for a long time
Significance.Anti-oxidant mean to oxidation resistant effect, makes cell from the damage of free radical, or is referred to as resistance human body because of oxygen
Compound matter is that oxygen radical causes the aging chronic disease such as cardiovascular and cerebrovascular diseases, diabetes, tumour, osteoarthropathy, senile dementia
Mechanism, so as to play anti-oxidant, anti-aging effects.
Although body has various polyphenoils to carry out the blocking to free radical, when this blocking is insufficient
(during such as illness, aging), the balance between the generation and elimination of free radical will be lost, and oxidative damage will occur.In order to add
Strong anti-preheater system, promote oxidation resistance, it is necessary to from supplementing the various materials with oxidation resistance in vitro, including various resist
Food and medicine, the i.e. defence of free radical and seizure property polyphenoils are aoxidized, with the ecological balance of environment in maintenance.Ordinary people is every
It is averagely taken in 1200~1500 unit ORAC (Oxygen Radical Absorbance Capacity) and refers to oxygen radical suction
Receipts ability, that is, test the general international standard unit of food and medicine moderate resistance oxide content.ORAC content is higher, suppresses freely
The oxidation resistance of base is stronger.But expert points out, balanced for protective intracellular metabolite, 5000~6000 must be taken in for each person every day
Unit ORAC.And inferior health and the elderly population amount of daily intaking then necessarily be greater than 10000 unit ORAC, normal generation could be maintained
Thank to balance, effectively drive away internal free radical, resist aging and various aging diseases.Therefore, human body must be mended additionally daily
Fill polyphenoils.The exogenous antioxidant being currently known mainly has：
Vitamin E：Also known as tocopherol, it is primarily present in cell mitochondrial film and endoplasmic reticulum, phenolic hydroxyl group can be by vivaciously
H atom freer base, become stable fertility quinone.One vitamin E can remove 2 free radicals, and vitamin E is anti-with ROO
Vitamin E free radical should be generated.Vitamin E can remove single line O2, and can removes alkane free radical and MDA is free
Base.It is directly acted on the cell membrane of human body, there is superpower oxidation resistance, specially catches oxygen radical, protects cell
Lipid on film is not oxidized, and cholesterol of giving a piece of bad advice can not adhere on vascular wall, keep the clean conditions of blood.
Vitamin C：Vitamin C, which removes, can remove free radical (such as O2, OH) outside, can also make fertility quinone recover vitamin E prototype,
Continue play remove free radical effect, as long as therefore have enough vitamin Cs, so that it may make the vitamin E of low concentration continue to play
Effect.Vitamin C is synthesized by glucose (G1u), because the mankind lack ester oxidase in Glu, so can not directly synthesize.Dimension
Raw plain C mainly absorbs in jejunum, and healthy human blood's content is 48.3~79.5umol/L.
Grape amine：That is cyanine oligomer (oligomeric proanthocyanidins complexes, OPC),
It is present in pine bark, peanut skin, grape pip, cowberry, lemon bark, dried orange peel and seabuckthorn seeds.It is 1986 big by French ripple Dorr
Learn Maas professor Kai Lier to find, be the most strong free radical scavenger found so far.The plant containing OPC has in the world
Kind more than 4000, and OPC (grape phenol) effect extracted from red grape pip is most obvious, its oxidation resistance is ascorbic 20
Again, 50 times of vitamin E.For correcting inferior health, make it that there is positive role to health conversion.
In addition, exogenous antioxidant is also red including beta carotene, polyphenyl phenol, children's phenol, isoflavones element, Lycopene, shrimp
Element, sesamol etc..
During different polyphenoils compounding uses, its antioxidant effect may be better than a kind of independent antioxygen of antioxidant
Change effect because during two or more polyphenoils compounding use, various antioxidants after anti-oxidant,
Caused free radical, which can interact, generates new phenolic compound, continues to play antioxidation, obtains its antioxygenic property
With enhancing.Therefore it provides a kind of composite antioxidant that can significantly increase antioxidant effect is significant.
The content of the invention
In view of this, the invention provides a kind of antioxidant composition and its application, health food.The present invention is by by perfume (or spice)
After melon extract, vitamin E and Se-enriched yeast are used cooperatively, in the case where greatly reducing each component dosage, the present invention provides
Composition be remarkably improved SOD vigor and GSH contents, generate obvious synergistic function, have significant anti-oxidant
Effect.
In order to realize foregoing invention purpose, the present invention provides following technical scheme：
The invention provides a kind of composition, including muskmelon extract, vitamin E and Se-enriched yeast.
Muskmelon, also known as muskmelon, property are sweet, cold, nontoxic；Muskmelon pedicel is bitter, cold, poisonous.Enter stomach, lung, large intestine.Containing a large amount of carbon hydrates
Thing and citric acid etc., and moisture is abundant, can relieve summer heat heat-clearing, quench one's thirst of promoting the production of body fluid, relieving restlessness；Invertase in muskmelon can be by insoluble protein
Qualitative change can help kidney patient to absorb nutrition into soluble protein；Vitamin B in the muskmelon base of a fruit can protect liver, mitigate
Chronic liver injury；Modern study finds that sunflower seed kills the effect such as roundworm, filaria；It is nutritious, needed by human body can be supplemented
Energy and nutrient.
Vitamin E (Vitamin E) is a kind of liposoluble vitamin, and its hydrolysate is tocopherol, is most important anti-
One of oxidant.It is dissolved in the organic solvents such as fat and ethanol, it is not soluble in water, it is stable to heat, acid, it is unstable to alkali, it is quick to oxygen
Sense, to heat it is insensitive, but it is fried when Vitamin E activity substantially reduce.Vitamin E has protection T lymphocytes, protection red thin
Born of the same parents, Green Tea Extract oxidation, the effect for suppressing platelet aggregation, so as to reduce the danger of myocardial infarction and cerebral infarction.Also to burning
Wound, frostbite, capillary hemorrhage, climacteric metancholia, beauty etc. have the effect of fine.It has also been found that vitamin E can suppress
Lipid peroxidation reaction in ocular lens body, make peripheral vasodilation, improve blood circulation.In addition, tocopherol can promotion property swash
Element secretion, make man's sperm motility and quantity increase；Increase woman's female hormone concentration, improve fecundity, prevention of miscarriage.
Recently it has also been found that vitamin E can suppress the lipid peroxidation reaction in ocular lens body, make peripheral vasodilation, improve blood and follow
Ring, pre- Anti-myopic eye occurrence and development.
Trace element necessary to selenium is human body, there is critically important physiological function, healthy closely related with the mankind.Selenium energy
Enough prevention and suppression tumours, anti-aging, the normal function for maintaining cardiovascular system, prevention of arterial hardening and the appearance of coronary heart disease.
Selenium deficiency can cause Keshan disease and big bone knot disease, can also induce cataract, hepatopathy and Pancreas Disease etc..Se-enriched yeast is in culture ferment
Add selenium element in female process, absorbed selenium during yeast growth, made selenium and the protein and polysaccharide organic in yeast
With reference to Biological Selenium is converted into, the toxicity and stomach of human body are stimulated so as to eliminate chemical selenium (such as sodium selenite), make selenium
Can more efficient, be more safely absorbed by the body utilization.Se-enriched yeast is also most efficient, most safe, nutrition domestic so far
Most balanced selenium-replenishing preparation.
After the present invention is by the way that muskmelon extract, vitamin E and Se-enriched yeast are used cooperatively, used greatly reducing each component
In the case of amount, composition provided by the invention is remarkably improved SOD vigor and GSH contents, generates obvious Synergistic
Effect.
In some embodiments provided by the invention, muskmelon extract can be commercially available prod, also can voluntarily be made.
In some embodiments provided by the invention, active constituent content >=1IU/mg in muskmelon extract.
Preferably, vitamin E is natural VE, i.e. d- alpha-tocopherols acetate.
In some embodiments provided by the invention, the active constituent content of vitamin E is >=50%.
In some embodiments provided by the invention, Se-enriched yeast is cereuisiae fermentum rich in selenoaminoacid.
In some embodiments provided by the invention, the content of selenium is 1000~1300ppm in cereuisiae fermentum rich in selenoaminoacid.
Preferably, the mass ratio of muskmelon extract, vitamin E and Se-enriched yeast is (1~10)：(0.1~3)：(0.3
~2).
In some embodiments provided by the invention, the mass ratio of muskmelon extract, vitamin E and Se-enriched yeast is 1:
0.1:0.3。
In other embodiments provided by the invention, the mass ratio of muskmelon extract, vitamin E and Se-enriched yeast is 5:
1.5:1。
In other embodiments provided by the invention, the mass ratio of muskmelon extract, vitamin E and Se-enriched yeast is
10:3:2。
Present invention also offers application of the said composition in anti-oxidation efficacy health food or medicine is prepared；Said composition
Including muskmelon extract, vitamin E and Se-enriched yeast；Preferably, the quality of muskmelon extract, vitamin E and Se-enriched yeast
Than for (1~10)：(0.1~3)：(0.3~2)；In some embodiments provided by the invention, muskmelon extract, vitamin E with
The mass ratio of Se-enriched yeast is 1:0.1:0.3；In other embodiments provided by the invention, muskmelon extract, vitamin E with
The mass ratio of Se-enriched yeast is 5:1.5:1；In other embodiments provided by the invention, muskmelon extract, vitamin E and richness
The mass ratio of selenium yeast is 10:3:2.
In some embodiments provided by the invention, anti-oxidation efficacy includes：MDA (MDA) content is reduced, is improved super
Superoxide dismutase (SOD) vigor, or improve glutathione (GSH) content.
Present invention also offers a kind of health food, including the present composition；Said composition includes muskmelon extract, dimension
Raw plain E and Se-enriched yeast；Preferably, the mass ratio of muskmelon extract, vitamin E and Se-enriched yeast is (1~10)：(0.1~
3)：(0.3~2)；In some embodiments provided by the invention, the mass ratio of muskmelon extract, vitamin E and Se-enriched yeast is
1:0.1:0.3；In other embodiments provided by the invention, the mass ratio of muskmelon extract, vitamin E and Se-enriched yeast is
5:1.5:1；In other embodiments provided by the invention, the mass ratio of muskmelon extract, vitamin E and Se-enriched yeast is
10:3:2。
In some embodiments provided by the invention, in addition to food additives.
In some embodiments provided by the invention, the formulation of health food is tablet, pulvis or capsule.But the present invention
This is not limited to, those skilled in the art think feasible formulation within protection scope of the present invention.
Preferably, food additives are selected from disintegrant, lubricant or adhesive in health caring food tablet.But the present invention is simultaneously
It is non-limiting in this, those skilled in the art think feasible food additives within protection scope of the present invention.
In some embodiments provided by the invention, disintegrant is carboxyrnethyl starch sodium or PVPP.But the present invention is simultaneously
It is non-limiting in this, those skilled in the art think feasible disintegrant within protection scope of the present invention.
In some embodiments provided by the invention, lubricant is silica, magnesium stearate.It is but of the invention and non-limiting
In this, those skilled in the art think feasible lubricant within protection scope of the present invention.
In some embodiments provided by the invention, adhesive is PVP, carboxycellulose sodium or syrup.But the present invention
This is not limited to, those skilled in the art think feasible adhesive within protection scope of the present invention.
Present invention also offers the preparation method of the health caring food tablet：Supplementary material is mixed, pelletized, tabletting, coating.
The invention provides a kind of antioxidant composition and its application, health food.Said composition include muskmelon extract,
Vitamin E and Se-enriched yeast.After the present invention is by the way that muskmelon extract, vitamin E and Se-enriched yeast are used cooperatively, subtracting significantly
In the case of few each component dosage, composition provided by the invention is remarkably improved SOD vigor and GSH contents, generates obvious
Synergistic function, there is significant anti-oxidation efficacy.
Embodiment
The invention discloses a kind of antioxidant composition and its application, health food, those skilled in the art can use for reference
Present disclosure, it is suitably modified technological parameter realization.In particular, all similar replacements and change are to this area skill
It is it will be apparent that they are considered as being included in the present invention for art personnel.The present invention method and application by compared with
Good embodiment is described, related personnel substantially can not depart from present invention, in spirit and scope to as described herein
Methods and applications are modified or suitably changed with combining, to realize and using the technology of the present invention.
Raw materials used or auxiliary material can be purchased by market in antioxidant composition provided by the invention and its application, health food
.Wherein, muskmelon extract supplier is French ISOCELL companies；Natural VE supplier is U.S. ADM；Selenium-enriched beer
Yeast supplier is Angel Yeast Co., Ltd.
With reference to embodiment, the present invention is expanded on further：
The anti-oxidation function of embodiment 1 is tested
1st, experiment material
1.1 key instruments and reagent
Animal platform balance, thermostat water bath, spectrophotometer, ultraviolet specrophotometer, low-temperature and high-speed centrifuge, suspension device
Deng.MDA (MDA), protein carbonyl group, superoxide dismutase (SOD) and reductive glutathione (GSH) testing cassete are by green cloud
Its bio tech ltd provides.
1.2 experimental animal
From SPF levels Kunming kind Healthy female mouse, 6-8 week old, body weight 18-22g, by Guangdong Province medical experiment animal
Center provides.
1.3 dosage regimen
After animal is quarantined three days in laboratory conditions, seven groups are randomly divided into, every group 12, daily gavage tested material, is given
Medicine composition and dosage are shown in Table 1, are increased and decreased to sample amount according to body weight weekly and adjusted, and experimental period is 30 days, and contact gavage is prohibited after 30 days
Food 16 hours, adopts tail point hematometry MDA (MDA) content, whole blood polyphenoils reductive glutathione (GSH) content；Pluck
Eyeball blood sampling centrifugation is taken, takes serum to determine antioxidant enzyme superoxide mutase (SOD) vigor.Remarks：Mouse is administered according to people
10 times of body recommended amounts.
Composition and dosage is administered in table 1
2nd, result of the test
Influence of 2.1 samples to experimental animal Liver MDA
Influence of each group sample of table 2 to experimental animal Liver MDA
1-5 groups are tested compared with Normal group, last MDA contents is tested and has all declined compared with Normal group, wherein
First and secondth, four, six test groups are compared with Normal group significantly (P<0.05), the 5th test group is compared with Normal group significantly (P<
0.01)。
Influence (be shown in Table 3) of 2.2 samples to experimental animal liver superoxide dismutase (SOD) vigor.
Influence of the sample of table 3 to experimental animal liver superoxide dismutase (SOD) vigor
1-5 groups are tested with respect to Normal group, last SOD vigor (U/mL) is tested and is all increased compared with Normal group, its
In the five, the six test groups compared with Normal group extremely significantly (P<0.01), the 4th test group is compared with Normal group significantly (P<0.05),
First, second and third test group all increases compared with Normal group, but without significant relation (P ＞ 0.05).
Influence (be shown in Table 4) of 2.3 samples to experimental animal serum reductive glutathione GSH contents.
Influence of each group of table 4 to aged mouse whole blood reductive glutathione GSH contents
1-5 groups are tested with respect to Normal group, the 4th, the 5th group of experiment end GSH content (μ g/ μ L) is compared with Normal group all
Increase and significantly (P ＜ 0.05), the 6th test group GSH contents significantly improve (P ＜ 0.01) compared with Normal group pole, other
Control and control group GSH contents all increase, but without significant relation (P ＞ 0.05).
From above-mentioned result of the test：
In terms of composition is to the influence of superoxide dismutase (SOD) vigor, after each component dosage is greatly reduced, the
Four test group SOD vigor are compared with Normal group significant difference (P ＜ 0.05)；6th test group SOD vigor is poor compared with Normal group
Different notable (P ＜ 0.01)；And the first test group to the 3rd test group SOD vigor (P ＞ not notable compared with Normal group difference
0.05).It can be seen that composition provided by the invention is remarkably improved SOD vigor after each material is used in combination, generate bright
Aobvious synergistic function.
In terms of composition is to the influence of reductive glutathione GSH contents, after each component dosage is greatly reduced, the 4th
Test group GSH contents are compared with Normal group significant difference (P ＜ 0.05)；6th test group GSH contents are compared with Normal group difference
Significantly (P ＜ 0.01)；And the first test group to the 3rd test group GSH contents is not notable (P ＞ 0.05) compared with Normal group difference.
It can be seen that composition provided by the invention is remarkably improved GSH contents after each material is used in combination, obvious collaboration is generated
Synergistic effect.
The preparation of the antioxidant functional food of embodiment 2
The formula of antioxidant functional food capsule is as shown in table 5.
The formula (1000) of the antioxidant functional food capsule of table 5
The preparation technology of health-care edible capsule agent is as follows：
The supplementary material of formula ratio is weighed, it is standby；Each supplementary material is put into mixer and mixed 20~30 minutes.
Above-mentioned compound is packed into capsule using Autocapsulefillingmachine, loading amount is 0.4g/ grains.
The preparation of the antioxidant functional food of embodiment 3
The formula of antioxidant functional food tablet is as shown in table 6.
The formula of the antioxidant functional food tablet of table 6
The preparation technology of health caring food tablet is as follows：
Each supplementary material is weighed, tabletting is made 1000 according to a conventional method for mixing, every 600mg.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (6)
1. a kind of composition, it is characterised in that be made up of muskmelon extract, vitamin E and Se-enriched yeast；
The mass ratio of muskmelon extract, vitamin E and Se-enriched yeast is 1:0.1:0.3；
Or the mass ratio of muskmelon extract, vitamin E and Se-enriched yeast is 5:1.5:1.
2. application of the composition as claimed in claim 1 in anti-oxidation efficacy health food or medicine is prepared.
3. application according to claim 2, it is characterised in that the anti-oxidation efficacy includes：MDA contents are reduced, are improved
SOD vigor, or improve GSH contents.
4. a kind of health food, it is characterised in that including composition as claimed in claim 1.
5. health food according to claim 4, it is characterised in that also including food additives.
6. health food according to claim 4, it is characterised in that the formulation of the health food be tablet, pulvis or
Capsule.
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