CN109845741A - Nematicidal composition containing furfural - Google Patents

Abstract

The invention discloses a kind of nematicidal compositions containing furfural, it is A and B containing active constituent, wherein A is selected from furfural, B is selected from formula (I) compound, composition includes usual auxiliaries, active components A and B, and the mass parts ratio of A and B are to have apparent synergistic effect to nematode after 2:1~1:3, A and B are compounded in certain proportion, suitable for crop nematodiasis, especially crop root knot nematode disease caused by prevention and treatment pathogen nematode；The structural formula of B is as follows:

Description

Nematicidal composition containing furfural

Technical field

The invention belongs to technical field of pesticide, specifically disclose a kind of nematicidal composition containing furfural.

Technical background

Furfural (Furfural) is also known as 2 furan carboxyaldehyde, and it is the hydrogen atom quilt on 2, furans that scientific name, which is furaldehyde, The derivative that aldehyde radical replaces.It is initially made from rice bran and diluted acid heat together, so being called furfural.Furfural is by pentosan in acid The lower hydrolysis of effect generates pentose, then is cyclized by dehydration of pentoses.Furfural has prevention and treatment to eelworm harm in disclosing report Effect.

102696609 B of CN discloses the compound of formula (I), and specification [0027]-[0029] section discloses formula (I) The structural formula and synthetic method of compound, specification [0016] section disclose its activity to tomato root-knot eelworm.

Plant nematode is a kind of very harmful pathogenic microorganism, has a very wide distribution, is many kinds of, environment adapts to Ability is strong, can colonize in root system, stem, leaf, seed, young shoot and the fruit of plant, can be by feeding activity to host plant Mechanical damage is caused, and robs the nutrition of host plant, especially its esophageal gland secretion will lead to one system of host plant generation Epidemy becomes, and can also infect jointly host plant with other pathogenic microorganisms, cause compound disease, cause production loss.In the whole world In range, agricultural losses caused by plant nematode is annual are up to 100,000,000,000 dollars or more, seriously constrain agricultural economy Development.

Application chemical agent is one of most effective chemical means of prevention and treatment plant pathogeny line insect disease；With not cross resistance Novel pesticide is come to prevent and treat plant pathogeny line insect disease be a good solution；But according to PhillipsMcDougall company Research, compared to 2005-2008 years, between 2010-2014 years, discovery, 1 pesticide activity component of exploitation and registration it is flat 30,000,000 dollars of increased costs are researched and developed, 11.7% are increased in other words, up to 2.86 hundred million dollars.And in 2005-2008 years Between, the average unit cost of agricultural chemicals research and development is 2.56 hundred million dollars, increases 39% compared with 2000；Average research and development cost in 2000 is 1.84 hundred million dollars, 21% is increased compared with nineteen ninety-five, while the development cycle is 5-10, is difficult the upper plant pathogeny line insect caught up with generation The speed of drug resistance；Other methods such as crop structure adjustment, different pesticide rotations etc., in the actual operation process, have been difficult To apparent effect.

Exploitation new product pesticide price is expensive, the period is long, and in contrast, it develops and studies efficient, less toxic, low-residual answer And have with mixture invest small, lead time it is short and by attention both domestic and external, it is numerous and confused to increase development dynamics.

The combination of furfural and formula (I) compound has not been reported.

Summary of the invention

The invention belongs to technical field of compounded pesticide, provide a kind of synergetic pesticide composition that effective component is A and B, Middle A is selected from furfural, and B is selected from formula (I) compound, especially provides one kind for the prevention and control of crop nematodiasis for crop root knot nematode disease Effective management tool.

The invention is realized by the following technical scheme:

The present invention relates to a kind of synergistic compositions containing furfural compounding, and containing active components A and B, A is selected from furfural, B choosing From formula (I) compound, formula (I) structural formula of compound is as follows:

The weight part ratio of A and B is 2:1~1:3, and further preferred ratio is 2:1,1:1,1:2,1:3.

The composition effective component total content is 0.1%~70%；The weight of further preferably active component is group The 10%~50% of object total weight is closed, remaining is insecticides adjuvant.

The composition is added auxiliary agent and excipients and granule, suspending agent etc. is made agriculturally by certain technological means Common dosage form.

The granule dosage form weight percent composition are as follows: active components A 0.1~30%, active constituent B 0.1~ 40%, dispersing agent 0.1~2%, disintegrating agent 1~8%, wetting agent 0.1~1%, binder 0.1~3%, solid carrier complement to 100%.Specific production stage are as follows: specific production stage are as follows: be uniformly mixed active constituent and other auxiliary agents, with ultra micro air-flow powder Broken machine crushes, and through mediating, is then added in fluidized-bed granulation dryer and is granulated, dries, sieve, corresponding weight percent is made The granule of content；A is selected from furfural, and B is selected from formula (I) compound.

The wetting agent can be lauryl sodium sulfate, neopelex, sodium butylnaphthalenesulfonate, alkyl sulphur One or more of sour sodium, tea seed cake powder, spaonin powder, spaonin powder, cornstarch, sorghum starch, buckwheat etc..

The dispersing agent can be APES formaldehyde condensation product, naphthalenesulfonate formaldehyde condensation compound, to first Oxygroup fatty acyl anilinesulfonic acid, alkyl phenol polyoxyethylene ether, polycarboxylate, alkyl phenol polyoxyethylene ether sulfate, alkylbenzene Sulfonic acid calcium salt, EO-PO block polymer, alkyl phenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, gathers aliphatic ester sulfate One or more of ethylene glycol stearate, Oleate, nekal etc..

The disintegrating agent can be sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, croscarmellose sodium, Crospovidone, chitosan, sodium alginate, sodium bicarbonate, magnesium chloride, aluminium chloride, sodium chloride, urea, ammonium sulfate, bentonite etc. One or more of.

The solid carrier can be precipitated calcium carbonate, clay, kaolin, diatomite, bentonite, white carbon black, clay, One or more of attapulgite, talcum powder, quartz sand, wood powder, walnut parting, lignin, wheat bran, rice chaff, sawdust etc..

The binder can be sucrose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, polyvinylpyrrolidine Ketone, calcium carboxymethylcellulose, carboxy-propyl cellulose, dextrin, amylodextrin, polyvinylpyrrolidone, sticky kaolin, paraffin, One or more of rosin, wood powder etc..

The beneficial effects of the present invention are:

Formula (I) compound and furfural have synergistic effect to plant pathogeny line insect.

Specific embodiment

It is raw to survey embodiment

According to Sun Yunpei's Method, the synergistic effect of pharmacy mix is evaluated according to co-toxicity coefficient (CTC), i.e. CTC≤80 are association Same antagonism, 80 < CTC < 120 are joint action of antagonism, and CTC >=120 are synergistic function.Survey toxicity index (ATI)=(LC of standard agent₅₀The LC of/reagent agent₅₀)×100；

The virulence of the percentage composition+B medicament of A medicament refers in toxicity index × mixture of theoretical toxicity index TTI=A medicament The percentage composition of B medicament in number × mixture；

Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] × 100.

Room of formula (I) the compound furfural to Meloidogyne incognita (Meloidogyne incongnita Chitwood) Interior toxicity test, subjects pick up from the south separated in the Cucumber root-knot nematode disease insect gall in field using the graceful funnel method of shellfish Root-knot nematode (Meloidogyne incongnita Chitwood).

Using method measurement formula (I) compound, the The Toxicity Determination result of furfural and the combination of the two different proportion of tagging The prepared medical fluid of various concentration is pressed to the indoor biological activity of test worm.The nematode suspension of 0.5ml medical fluid and 0.5ml are added to In 24 well culture plates.Each processing is repeated 3 times.24 orifice plates are obturaged with sealed membrane and are placed on 48h in 25 DEG C of incubators, it then will be each Processing and control nematode suspension pour into 500 meshes and filter off medical fluid, with aseptic water washing and recycle nematode in culture dish, Microscopy nematode death condition after for 24 hours, calculates corrected mortality, acquires virulence regression equation and calculate LC₅₀Value.

Table 1: formula (I) compound furfural is to Meloidogyne incognita (Meloidogyne incongnita Chitwood) The Toxicity Determination result (activity of second instar larvae).

As shown in Table 1, formula (I) compound and furfural mixture are between 2:1~1:3, to Meloidogyne incognita (Meloidogyne incongnita Chitwood) has synergistic effect, and co-toxicity coefficient is 120 or more；Formula (I) compound With furfural between 50:1-5:1 and 1:5-1:30 is to Meloidogyne incognita (Meloidogyne incongnita Chitwood) There is no synergistic effect.

Example of formulations

5% formula (I) compound, 10% furfural granule

Weigh 5% formula (I) compound, 10% furfural, 8% rice chaff, 2% sodium polycarboxylate, 1% sodium bicarbonate, high concave convex rod Soil complements to 100%, and active constituent and other auxiliary agents are uniformly mixed, and through mediating, is then added in fluidized-bed granulation dryer It is granulated, dried, sieved, 5% formula (I) compound, 10% furfural granule is made.

Application Example

Table 2 formula (I) compound composition prevents and treats globodera rostochiensis disease, and (test method is referring to GB/T17980.38- 2000)。

Claims (10)

1. the nematicidal composition containing furfural, it is characterised in that: active constituent is A and B, and wherein A is selected from furfural, and B is selected from formula (I) The mass fraction ratio of compound, A and B are as follows: 2:1~1:3；The structural formula of B is

2. composition according to claim 1, it is characterised in that: the mass fraction ratio of A and B are as follows: 2:1.

3. composition according to claim 1, it is characterised in that: the mass fraction ratio of A and B are as follows: 1:1.

4. composition according to claim 1, it is characterised in that: the mass fraction ratio of A and B are as follows: 1:2.

5. composition according to claim 1, it is characterised in that: the mass fraction ratio of A and B are as follows: 1:3.

6. composition described in any one according to claim 1~5, the weight of active component is composition total weight 0.1%~70%, remaining is insecticides adjuvant.

7. composition described in any one according to claim 1~5, the weight of active component is the 10% of composition total weight ~50%, remaining is insecticides adjuvant.

8. composition described in claim 1~7 any one is for preventing and treating the crop nematodiasis as caused by crop pathogenic nematode On purposes.

9. purposes according to claim 8, the crop pathogenic nematode is Meloidogyne incognita.

10. purposes according to claim 8, the nemas is globodera rostochiensis disease.