CN109837598A - A kind of micro-fluidic device for spinning and method - Google Patents
A kind of micro-fluidic device for spinning and method Download PDFInfo
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- CN109837598A CN109837598A CN201910308070.6A CN201910308070A CN109837598A CN 109837598 A CN109837598 A CN 109837598A CN 201910308070 A CN201910308070 A CN 201910308070A CN 109837598 A CN109837598 A CN 109837598A
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Abstract
The present invention relates to microfluidic art more particularly to a kind of micro-fluidic device for spinning and method, the micro-fluidic device for spinning includes: the first air guide micro-pipe；Drain micro-pipe inside the first air guide micro-pipe is set；The first air guide micro-pipe and drain micro-pipe coaxial placement；The outlet tube mouth of the drain micro-pipe is located inside the first air guide micro-pipe；The import of the drain micro-pipe is connected with fluid injector, and the import of the first air guide micro-pipe is connected with the first air pump.The solution exported from the outlet tube mouth of the drain micro-pipe forms fiber under the shear action for the sheaths gas that the first air guide micro-pipe exports, and under the focussing force of the sheaths gas, promotes the stability of the solid jet of the solution.Meanwhile the pre-stretching effect of sheaths gas can make the fiber of preparation have better internal approach, promote the mechanical property of fiber.Thus, the fibre diameter of micro-fluidic device for spinning production provided by the invention is smaller, and mechanical property is more excellent.
Description
Technical field
The present invention relates to microfluidic art more particularly to a kind of micro-fluidic device for spinning and methods.
Background technique
Micro/nano-fiber material is the hot spot of every field research instantly, all multi-party in military affairs, the energy, chemical industry, medicine etc.
It is applied in face.Micro Nano material is made it have due to itself lesser size and is different from stock size material
Specific physical chemical property.Nanofiber is an important branch of nano material, since it is with good mechanical property, biography
The features such as leading effect and high-specific surface area receives more and more attention and research.But the technology of nanofiber is prepared at present
If dry spinning, wet spinning, electrostatic spinning are all still immature, dry spinning yield is lower, and wet spinning process flow is complicated,
The applicable range of polymers of electrostatic spinning is smaller, all have the defects that it is certain, meanwhile, the mechanical property of obtained nanofiber has
To which the fibrous material for meeting people's requirement in raising, can not be prepared.
Summary of the invention
In view of this, using the technical problem to be solved in the present invention is that provide a kind of micro-fluidic device for spinning and method
The fibre diameter of micro-fluidic device for spinning production of the invention is smaller, mechanical property is more excellent.
The present invention provides a kind of micro-fluidic device for spinning, comprising:
First air guide micro-pipe；
Drain micro-pipe inside the first air guide micro-pipe is set；
The first air guide micro-pipe and drain micro-pipe coaxial placement；The outlet tube mouth of the drain micro-pipe is located at described first
Inside air guide micro-pipe；
The import of the drain micro-pipe is connected with fluid injector, the import and the first air pump of the first air guide micro-pipe
It is connected.
Preferably, the outlet mouth of pipe of the first air guide micro-pipe is taper, and the outlet tube mouth of the drain micro-pipe is taper.
Preferably, the import of the drain micro-pipe is connected by polyethylene pipe with the liquid outlet of fluid injector, described
The import of first air guide micro-pipe is connected by the first rubber tube with the gas vent of the first air pump.
It preferably, further include syringe pump and the first air valve；
The syringe pump is connected with fluid injector, for controlling the feed speed of fluid injector；
It is provided with the first air valve between the first air guide micro-pipe and the first air pump, it is micro- for controlling the first air guide
The gas flow rate of pipe entrance.
It preferably, further include the second air guide micro-pipe and the second air pump；
The first air guide micro-pipe is arranged inside the second air guide micro-pipe；The second air guide micro-pipe, the first air guide
Micro-pipe and drain micro-pipe coaxial placement；The outlet mouth of pipe of the first air guide micro-pipe is located at the inside of the second air guide micro-pipe；
The import of the second air guide micro-pipe is connected with the second air pump.
Preferably, the outlet mouth of pipe of the second air guide micro-pipe is taper；
The import of the second air guide micro-pipe is connected by the second rubber tube with the gas vent of the second air pump.
It preferably, further include the second air valve；
It is provided with the second air valve between the second air guide micro-pipe and the second air pump, it is micro- for controlling the second air guide
The gas flow rate of pipe entrance.
The present invention also provides a kind of methods that micro-fluidic spinning is carried out on micro-fluidic device for spinning described above, including
Following steps:
Protein solution is passed through drain micro-pipe by fluid injector, the feed speed for controlling the fluid injector is
0.5~2mL/h；
The first sheath gas is passed through the first air guide micro-pipe by the first air pump, controls the gas of the first air guide micro-pipe entrance
Flow velocity is 1~50mL/min；The first sheath gas is the gas not reacted with protein solution；
The liquid being discharged from the drain micro-pipe forms fiber by the effect of the first sheath gas.
Preferably, the micro-fluidic device for spinning further includes the second air guide micro-pipe and the second air pump；
The first air guide micro-pipe is arranged inside the second air guide micro-pipe；The second air guide micro-pipe, the first air guide
Micro-pipe and drain micro-pipe coaxial placement；The outlet mouth of pipe of the first air guide micro-pipe is located at the inside of the second air guide micro-pipe；
The import of the second air guide micro-pipe is connected with the second air pump；
The second sheath gas is passed through the second air guide micro-pipe by the second air pump, controls the gas of the second air guide micro-pipe entrance
Flow velocity is 3~70mL/min；The second sheath gas is the gas not reacted with protein solution；
The liquid being discharged from the drain micro-pipe forms fiber by the effect of the first sheath gas and the second sheath gas, and via the
The outlet mouth of pipe wire vent of two air guide micro-pipes.
The present invention provides a kind of micro-fluidic device for spinning, comprising: the first air guide micro-pipe；It is arranged micro- in first air guide
Drain micro-pipe inside pipe；The first air guide micro-pipe and drain micro-pipe coaxial placement；The outlet tube mouth position of the drain micro-pipe
Inside the first air guide micro-pipe；The import of the drain micro-pipe is connected with fluid injector, the first air guide micro-pipe
Import is connected with the first air pump.The sheath that the solution exported from the outlet tube mouth of the drain micro-pipe is exported in the first air guide micro-pipe
Under the shear action of layer gas, solvent volatilization, solute solidification, so that fiber is formed, under the focussing force of the sheaths gas,
The stability of the solid jet of the solution can further be promoted.Meanwhile the pre-stretching effect of sheaths gas can make institute
The fiber of preparation has better internal approach, promotes the mechanical property of the fiber of preparation.Thus, it is provided by the invention micro-fluidic
The fibre diameter of device for spinning production is smaller, and mechanical property is more excellent.
The present invention utilizes focus air stream using the micro-fluidic spining technology of sheath gas focusing by simulation spider spinning process
Shear tension power, induce the formation and orientation of greater protein folding region, the oil-free method of a step prepares fiber, can be obviously improved fibre
Tie up mechanical property.
Detailed description of the invention
Fig. 1 is the structural schematic diagram for the micro-fluidic device for spinning that one embodiment of the present of invention provides；
Fig. 2 be another embodiment of the present invention provides micro-fluidic device for spinning structural schematic diagram.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical solution of the present invention is clearly and completely described, it is clear that institute
The embodiment of description is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention,
Every other embodiment obtained by those of ordinary skill in the art without making creative efforts, belongs to this hair
The range of bright protection.
The present invention provides a kind of micro-fluidic device for spinning, comprising:
First air guide micro-pipe；
Drain micro-pipe inside the first air guide micro-pipe is set；
The first air guide micro-pipe and drain micro-pipe coaxial placement；The outlet tube mouth of the drain micro-pipe is located at described first
Inside air guide micro-pipe；
The import of the drain micro-pipe is connected with fluid injector, the import and the first air pump of the first air guide micro-pipe
It is connected.
Structure is the structural schematic diagram for the micro-fluidic device for spinning that one embodiment of the present of invention provides referring to Fig. 1, Fig. 1.
Wherein, 1 is drain micro-pipe, and 2 be the first air guide micro-pipe, and 4 be the first air pump, and 5 be the first air valve, and 6 be fluid injector, 7
For syringe pump.In certain embodiments of the present invention, the drain micro-pipe 1 and the first air guide micro-pipe 2 can be carried by being fixed on
On slide, micro-fluidic device is constituted.It specifically can be with are as follows: lie in the first air guide micro-pipe 2 on glass slide, with AB glue by first
The tube body of air guide micro-pipe 2 is bonded on glass slide.The drain micro-pipe 1 is filled in the first air guide micro-pipe 2.The drain is micro-
Pipe 1 and the first air guide micro-pipe 2 constitute the multilayered structure of outer tube sleeve inner tube.
Micro-fluidic device for spinning provided by the invention includes the first air guide micro-pipe 2.The first air guide micro-pipe 2 is for conveying
First sheath gas.The first sheath gas that the solution exported from the outlet tube mouth of the drain micro-pipe 1 is exported in the first air guide micro-pipe 2 is cut
It cuts under effect, solvent volatilization, solute solidification, so that fiber is formed, it, can be further under the focussing force of the first sheath gas
Promote the stability of the solid jet of the solution.Meanwhile first sheath gas pre-stretching effect can make prepared fiber
With better internal approach, the mechanical property of the fiber of preparation is promoted.
In certain embodiments of the present invention, the first air guide micro-pipe 2 is cylindrical glass micro-pipe.In certain of the invention
In a little embodiments, the internal diameter of the first air guide micro-pipe is 550 μm.In certain embodiments of the present invention, first air guide
The outlet tube mouth of micro-pipe is set as taper.Specifically, the cone direction of the taper is outgassing direction.In certain embodiments,
The caliber of the outlet mouth of pipe of the first air guide micro-pipe is 200 μm.
The micro-fluidic device for spinning further includes the first air pump 4.The import of the first air guide micro-pipe 2 and the first air
Pump 4 is connected.In an embodiment of the present invention, the import of the first air guide micro-pipe passes through the first rubber tube and the first air pump
Gas vent is connected.
In an embodiment of the present invention, the micro-fluidic device for spinning further includes the first air valve 5.First air valve
5 are arranged between the first air guide micro-pipe and the first air pump, for controlling the gas flow rate of the first air guide micro-pipe entrance.
The present invention has no special limitation to the type of first air valve, is using air valve well known to those skilled in the art
It can.The present invention has no special limitation to the type of first air pump, using air pump well known to those skilled in the art
?.
Micro-fluidic device for spinning provided by the invention further includes drain micro-pipe 1.The drain micro-pipe 1 is arranged described first
Inside air guide micro-pipe 2.The drain micro-pipe 1 is for being passed through the solution to form fiber.In an embodiment of the present invention, the drain
Micro-pipe 1 is cylindrical glass micro-pipe.In certain embodiments of the present invention, the internal diameter of the drain micro-pipe is 160 μm.In this hair
In bright some embodiments, the outlet tube mouth of the drain micro-pipe is set as taper.Specifically, the cone direction of the taper is
Liquid direction out.In certain embodiments, the caliber of the outlet tube mouth of the drain micro-pipe is 80 μm.
In the present invention, it does not include that drain is micro- that the outlet tube mouth of the drain micro-pipe, which is located inside the first air guide micro-pipe,
The outlet tube mouth of pipe and the air guide nozzle of the first air guide micro-pipe are the same plane the case where.Specifically, going out liquid from drain micro-pipe
The solution of nozzle output enters the first air guide micro-pipe, under the shear action of the first sheath gas of the first air guide micro-pipe, solvent volatilization,
Solute solidification is sent out to form fiber via the outlet mouth of pipe of the first air guide micro-pipe.
The micro-fluidic device for spinning further includes fluid injector 6.The import of the drain micro-pipe 1 and fluid injector 6
It is connected.In an embodiment of the present invention, the import of the drain micro-pipe is connected by polyethylene pipe with the outlet of fluid injector.
In an embodiment of the present invention, the micro-fluidic device for spinning further includes syringe pump 7.The syringe pump 7 and liquid
Syringe 6 is connected, and for promoting fluid injector 6, and then controls the feed speed of fluid injector 6.Specifically, the liquid
Syringe is clamped on the syringe pump, promotes fluid injector by syringe pump, and then it is micro- that fiber solution is injected into drain
Guan Zhong.The present invention has no special limitation to the type of the solution injector 6, is applicable in using well known to those skilled in the art
In the syringe of syringe pump.In certain embodiments of the present invention, the size of the screw socket syringe of the fluid injector is
3mL, 5mL or 10mL.For the present invention to the type of the syringe pump also without special limitation, use is well known to those skilled in the art
It can be suitable for the syringe pump of fluid injector.In certain embodiments of the present invention, the syringe pump is
LongerPump LSP01-1A micro-injection pump.
In the present invention, the first air guide micro-pipe 2 and 1 coaxial placement of drain micro-pipe.
In certain embodiments of the present invention, the micro-fluidic device for spinning further includes the second air guide micro-pipe 3.Described first
Air guide micro-pipe is arranged inside the second air guide micro-pipe, and the second air guide micro-pipe is for conveying the second sheath gas.Structure referring to
Fig. 2, Fig. 2 be another embodiment of the present invention provides micro-fluidic device for spinning structural schematic diagram.Wherein, it 3 is led for second
Gas micro-pipe, 8 be the second air pump, and 9 be the second air valve.
In the present invention, the outlet mouth of pipe of the first air guide micro-pipe 2 is located at the inside of the second air guide micro-pipe 3, does not wrap
The outlet mouth of pipe of the first air guide micro-pipe and the air guide nozzle of the second air guide micro-pipe are included the same plane the case where.Specifically, from leading
The solution of the outlet tube mouth discharge of liquid micro-pipe is introduced into the first air guide micro-pipe 2, is entered back into the second air guide micro-pipe 3, by the
The effect of one sheath gas and the second sheath gas, solvent volatilization, solute solidification, so that fiber is formed, via the outlet of the second air guide micro-pipe
Nozzle discharge.
The solution being discharged from the outlet tube mouth of the drain micro-pipe 1 forms fibre by the effect of the first sheath gas and the second sheath gas
Dimension, under the focussing force of two layers of sheath gas, has facilitation for further promoting the stability of solid jet of the solution.
Meanwhile the pre-stretching effect of two layers of sheath gas can reinforce focusing function, further such that prepared fiber has in preferably
Portion's orientation, further promotes the mechanical property of the fiber of preparation.
In certain embodiments of the present invention, the second air guide micro-pipe 3 is cylindrical glass micro-pipe.In certain of the invention
In a little embodiments, the outer diameter of the second air guide micro-pipe is 1.05mm, internal diameter 1.5mm.In certain embodiments of the present invention,
The outlet tube mouth of the second air guide micro-pipe is set as taper.Specifically, the cone direction of the taper is outgassing direction.At certain
In a little embodiments, the caliber of the outlet mouth of pipe of the second air guide micro-pipe is 400 μm.
The micro-fluidic device for spinning further includes the second air pump 9.The import of the second air guide micro-pipe 3 and the second air
Pump 9 is connected.In an embodiment of the present invention, the import of the second air guide micro-pipe passes through the second rubber tube and the second air pump
Gas vent is connected.
In an embodiment of the present invention, the micro-fluidic device for spinning further includes the second air valve 10.Second air
Valve 10 is arranged between the second air guide micro-pipe and the second air pump, for controlling the gas stream of the second air guide micro-pipe entrance
Speed.The present invention has no special limitation to the type of second air valve, using air valve well known to those skilled in the art
?.The present invention has no special limitation to the type of second air pump, using air well known to those skilled in the art
Pump.
The present invention also provides a kind of methods that micro-fluidic spinning is carried out on micro-fluidic device for spinning described above, including
Following steps:
Protein solution is passed through drain micro-pipe by fluid injector, the feed speed for controlling the fluid injector is
0.5~2mL/h；
The first sheath gas is passed through the first air guide micro-pipe by the first air pump, controls the gas of the first air guide micro-pipe entrance
Flow velocity is 1~50mL/min；The first sheath gas is the gas not reacted with protein solution；
The liquid being discharged from the drain micro-pipe forms fiber by the effect of the first sheath gas.
In an embodiment of the present invention, the protein solution includes collagen solution or bovine serum albumen solution.It is described
The concentration of protein solution is 4~30wt%.In certain embodiments, the concentration of the protein solution is 10wt%.
The feed speed of the fluid injector is 0.5~2mL/h.In certain embodiments of the present invention, the liquid
The feed speed of syringe is 1mL/h.
The first sheath gas is the gas not reacted with protein solution.In an embodiment of the present invention, described first
Sheath gas is air or nitrogen.The gas flow rate of first air guide micro-pipe entrance is 1~50mL/min.In certain implementations of the invention
In example, the gas flow rate of the first air guide micro-pipe entrance is 10mL/min or 50mL/min.
The flow velocity of the flow velocity of liquid and gas in the first air guide micro-pipe in drain micro-pipe is adjusted, regulation sheaths gas is to logical
The shearing force of liquid in road can accelerate solvent volatilization and solute solidification, to accelerate to form fiber.In the focusing of sheaths gas
Under effect, the stability of solid jet is promoted；Under the pre-stretching effect of sheaths gas there is prepared fiber in preferably
Portion's orientation, promotes fibrous mechanical property.
In certain embodiments of the present invention, the micro-fluidic device for spinning further includes the second air guide micro-pipe and the second air
Pump；
The first air guide micro-pipe is arranged inside the second air guide micro-pipe；The second air guide micro-pipe, the first air guide
Micro-pipe and drain micro-pipe coaxial placement；The outlet mouth of pipe of the first air guide micro-pipe is located at the inside of the second air guide micro-pipe；
The import of the second air guide micro-pipe is connected with the second air pump；
The second sheath gas is passed through the second air guide micro-pipe by the second air pump, controls the gas of the second air guide micro-pipe entrance
Flow velocity is 3~70mL/min；The second sheath gas is the gas not reacted with protein solution；
The liquid being discharged from the drain micro-pipe forms fiber by the effect of the first sheath gas and the second sheath gas, and via the
The outlet mouth of pipe wire vent of two air guide micro-pipes, collects fiber in fiber collecting pipe.
The second sheath gas is the gas not reacted with protein solution.In an embodiment of the present invention, described second
Sheath gas is air or nitrogen.The gas flow rate of second air guide micro-pipe entrance is 3~70mL/min.In certain implementations of the invention
In example, the gas flow rate of the second air guide micro-pipe entrance is 15mL/min or 70mL/min.
The solution being discharged from the outlet tube mouth of the drain micro-pipe 1 forms fibre by the effect of the first sheath gas and the second sheath gas
Dimension, under the focussing force of two layers of sheath gas, has facilitation for further promoting the stability of solid jet of the solution.
Meanwhile the pre-stretching effect of two layers of sheath gas can be further such that prepared fiber has better internal approach, further
Promote the mechanical property of the fiber of preparation.
The present invention has no special limitation to the source of above-mentioned used raw material components, can be general commercially available.
The present invention provides a kind of micro-fluidic device for spinning, comprising: the first air guide micro-pipe；It is arranged micro- in first air guide
Drain micro-pipe inside pipe；The first air guide micro-pipe and drain micro-pipe coaxial placement；The outlet tube mouth position of the drain micro-pipe
Inside the first air guide micro-pipe；The import of the drain micro-pipe is connected with fluid injector, the first air guide micro-pipe
Import is connected with the first air pump.The sheath that the solution exported from the outlet tube mouth of the drain micro-pipe is exported in the first air guide micro-pipe
Under the shear action of layer gas, solvent volatilization, solute solidification, so that fiber is formed, under the focussing force of the sheaths gas,
The stability of the solid jet of the solution can further be promoted.Meanwhile the pre-stretching effect of sheaths gas can make institute
The fiber of preparation has better internal approach, promotes the mechanical property of the fiber of preparation.Thus, it is provided by the invention micro-fluidic
The fibre diameter of device for spinning production is smaller, and mechanical property is more excellent.
The experimental results showed that the diameter of fiber prepared by the present invention can be 50 μm~1mm；In certain embodiments, institute
The diameter for stating fiber is 50 μm.The breaking strength for the fiber that collagen solution is formed can be 300~400MPa；In certain realities
It applies in example, the breaking strength of the fiber is 400Mpa.The breaking strength for the fiber that bovine serum albumen solution is formed can be 250
~300Mpa；In certain embodiments, the breaking strength of the fiber is 300Mpa.
In order to further illustrate the present invention, with reference to embodiments to a kind of micro-fluidic device for spinning provided by the invention and
Method is described in detail, but cannot be understood as limiting the scope of the present invention.
Raw material components used in following embodiment are general commercially available.
Embodiment 1
Micro-fluidic spinning is carried out on micro-fluidic device for spinning shown in Fig. 1, specific:
The micro-fluidic device for spinning includes:
First air guide micro-pipe 2；The first air guide micro-pipe is cylindrical glass micro-pipe, the internal diameter of the first air guide micro-pipe
It is 550 μm, the caliber of the outlet mouth of pipe of the first air guide micro-pipe is 200 μm；
The import of the first air guide micro-pipe 2 is connected by the first rubber tube with the gas vent of the first air pump 4, described
First air valve 5 is arranged between the first air guide micro-pipe and the first air pump, for controlling 2 entrance of the first air guide micro-pipe
Gas flow rate；
Drain micro-pipe 1 inside the first air guide micro-pipe 2 is set；The drain micro-pipe 1 is cylindrical glass micro-pipe,
The internal diameter of the drain micro-pipe is 160 μm, and the caliber of the outlet tube mouth of the drain micro-pipe is 80 μm；
The import of the drain micro-pipe 1 is connected by polyethylene pipe with the outlet of fluid injector 6, the syringe pump 7 and
Fluid injector 6 is connected, for controlling the feed speed of fluid injector 6；
The first air guide micro-pipe 2 and 1 coaxial placement of drain micro-pipe, the outlet tube mouth of the drain micro-pipe are located at described the
Inside one air guide micro-pipe 2.
The collagen solution (or bovine serum albumen solution) that concentration is 10wt% is passed through drain by fluid injector
Micro-pipe 1, the feed speed for controlling the fluid injector 7 is 1mL/h；It is micro- that nitrogen is passed through the first air guide by the first air pump
Pipe, the gas flow rate of the first air guide micro-pipe entrance of control are 10mL/min；The collagen being discharged from the drain micro-pipe 1 is molten
Liquid (or bovine serum albumen solution) passes through under the action of nitrogen, solvent volatilization, solute solidification, to form fiber.
Through detecting, the diameter of fiber manufactured in the present embodiment is 50 μm.The fracture for the fiber that collagen solution is formed is strong
Degree is in 300~400MPa, and the breaking strength of the fiber of bovine serum albumen solution formation is in 250~300Mpa.
Embodiment 2
Micro-fluidic spinning is carried out on micro-fluidic device for spinning shown in Fig. 2, specific:
The micro-fluidic device for spinning includes:
Second air guide micro-pipe 3；The second air guide micro-pipe is cylindrical glass micro-pipe, the outer diameter of the second air guide micro-pipe
For 1.05mm, internal diameter 1.5mm, the caliber of the outlet tube mouth of the second air guide micro-pipe is 400 μm；
The import of the second air guide micro-pipe 3 is connected by the second rubber tube with the gas vent of the second air pump 9, described
Second air valve 10 is arranged between the second air guide micro-pipe and the second air pump, for controlling 3 import of the second air guide micro-pipe
The gas flow rate at place；
The first air guide micro-pipe 2 inside the second air guide micro-pipe 3 is set；The first air guide micro-pipe is cylindrical glass
Glass micro-pipe, the internal diameter of the first air guide micro-pipe are 550 μm, and the caliber of the outlet mouth of pipe of the first air guide micro-pipe is 200 μm；
The import of the first air guide micro-pipe 2 is connected by the first rubber tube with the gas vent of the first air pump 4, described
First air valve 5 is arranged between the first air guide micro-pipe and the first air pump, for controlling 2 entrance of the first air guide micro-pipe
Gas flow rate；
Drain micro-pipe 1 inside the first air guide micro-pipe 2 is set；The drain micro-pipe 1 is cylindrical glass micro-pipe,
The internal diameter of the drain micro-pipe is 160 μm, and the caliber of the outlet tube mouth of the drain micro-pipe is 80 μm；
The import of the drain micro-pipe 1 is connected by polyethylene pipe with the outlet of fluid injector 6, the syringe pump 7 and
Fluid injector 6 is connected, for controlling the feed speed of fluid injector 6；
The second air guide micro-pipe 3,1 coaxial placement of the first air guide micro-pipe 2 and drain micro-pipe, the drain micro-pipe go out liquid
Nozzle is located inside the first air guide micro-pipe 2, and the outlet mouth of pipe of the first air guide micro-pipe 2 is located at the second air guide micro-pipe
Inside 3.
The collagen solution (or bovine serum albumen solution) that concentration is 10wt% is passed through drain by fluid injector
Micro-pipe 1, the feed speed for controlling the fluid injector 7 is 1mL/h；It is micro- that nitrogen is passed through the first air guide by the first air pump
Pipe, the gas flow rate of the first air guide micro-pipe entrance of control are 10mL/min；Air second is passed through by the second air pump to lead
Gas micro-pipe, the gas flow rate of the second air guide micro-pipe entrance of control are 15mL/min；The collagen egg being discharged from the drain micro-pipe
White solution (or bovine serum albumen solution) passes through the effect of nitrogen and air, solvent volatilization, and solute solidification forms fiber.
Through detecting, the diameter of fiber manufactured in the present embodiment is 50 μm.The fracture for the fiber that collagen solution is formed is strong
Degree is in 300~400MPa, and the breaking strength of the fiber of bovine serum albumen solution formation is in 250~300Mpa.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be readily apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest scope of cause.
Claims (9)
1. a kind of micro-fluidic device for spinning, comprising:
First air guide micro-pipe；
Drain micro-pipe inside the first air guide micro-pipe is set；
The first air guide micro-pipe and drain micro-pipe coaxial placement；The outlet tube mouth of the drain micro-pipe is located at first air guide
Inside micro-pipe；
The import of the drain micro-pipe is connected with fluid injector, the import of the first air guide micro-pipe and the first air pump phase
Even.
2. micro-fluidic device for spinning according to claim 1, which is characterized in that the outlet mouth of pipe of the first air guide micro-pipe
For taper, the outlet tube mouth of the drain micro-pipe is taper.
3. micro-fluidic device for spinning according to claim 1, which is characterized in that the import of the drain micro-pipe passes through poly- second
Alkene pipe is connected with the liquid outlet of fluid injector, and the import of the first air guide micro-pipe passes through the first rubber tube and the first air
The gas vent of pump is connected.
4. micro-fluidic device for spinning according to claim 1, which is characterized in that further include syringe pump and the first air valve；
The syringe pump is connected with fluid injector, for controlling the feed speed of fluid injector；
Be provided with the first air valve between the first air guide micro-pipe and the first air pump, for control the first air guide micro-pipe into
Gas flow rate at mouthful.
5. micro-fluidic device for spinning according to claim 1, which is characterized in that further include that the second air guide micro-pipe and second are empty
Air pump；
The first air guide micro-pipe is arranged inside the second air guide micro-pipe；The second air guide micro-pipe, the first air guide micro-pipe
With drain micro-pipe coaxial placement；The outlet mouth of pipe of the first air guide micro-pipe is located at the inside of the second air guide micro-pipe；
The import of the second air guide micro-pipe is connected with the second air pump.
6. micro-fluidic device for spinning according to claim 5, which is characterized in that the outlet mouth of pipe of the second air guide micro-pipe
For taper；
The import of the second air guide micro-pipe is connected by the second rubber tube with the gas vent of the second air pump.
7. micro-fluidic device for spinning according to claim 5, which is characterized in that further include the second air valve；
Be provided with the second air valve between the second air guide micro-pipe and the second air pump, for control the second air guide micro-pipe into
Gas flow rate at mouthful.
8. carrying out the method for micro-fluidic spinning on a kind of micro-fluidic device for spinning described in claim 1, comprising the following steps:
Protein solution is passed through drain micro-pipe by fluid injector, control the fluid injector feed speed be 0.5~
2mL/h；
The first sheath gas is passed through the first air guide micro-pipe by the first air pump, controls the gas flow rate of the first air guide micro-pipe entrance
For 1~50mL/min；The first sheath gas is the gas not reacted with protein solution；
The liquid being discharged from the drain micro-pipe forms fiber by the effect of the first sheath gas.
9. micro-fluidic spinning process according to claim 8, which is characterized in that the micro-fluidic device for spinning further includes
Two air guide micro-pipes and the second air pump；
The first air guide micro-pipe is arranged inside the second air guide micro-pipe；The second air guide micro-pipe, the first air guide micro-pipe
With drain micro-pipe coaxial placement；The outlet mouth of pipe of the first air guide micro-pipe is located at the inside of the second air guide micro-pipe；
The import of the second air guide micro-pipe is connected with the second air pump；
The second sheath gas is passed through the second air guide micro-pipe by the second air pump, controls the gas flow rate of the second air guide micro-pipe entrance
For 3~70mL/min；The second sheath gas is the gas not reacted with protein solution；
The liquid being discharged from the drain micro-pipe forms fiber by the effect of the first sheath gas and the second sheath gas, and leads via second
The outlet mouth of pipe wire vent of gas micro-pipe.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111334883A (en) * | 2020-04-21 | 2020-06-26 | 中国科学院长春应用化学研究所 | Preparation and application of natural protein fiber |
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