CN109806339A - A kind of preparation and preparation method thereof improving endocrine integration of drinking and medicinal herbs - Google Patents
A kind of preparation and preparation method thereof improving endocrine integration of drinking and medicinal herbs Download PDFInfo
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Abstract
The invention particularly discloses a kind of preparations for improving endocrine integration of drinking and medicinal herbs, formulation by weight is as follows: hawthorn, lily, Radix Angelicae Sinensis, rhizoma polygonati, lotus seeds, Chinese yam, peach kernel, raspberry, Radix Codonopsis, dendrobium candidum, Radix Astragali and Rhizoma Chuanxiong, is refined into tablet, granule, pill, capsule and mixture by each dosage formulation requirement.The preparation of conditioning endocrine integration of drinking and medicinal herbs provided by the invention has therapeutic effect not only for endocrine disorder, can treat some related symptoms caused by endocrine disorder；Because the material used is that the material of integration of drinking and medicinal herbs is small to liver kidney burden, it can be used for the case where daily body conditioning is used, solves modern human body inferior health, improve the physical fitness of people, anti-treating diseases and making health-care.
Description
Technical field
The present invention relates to Chinese medicine and its preparation fields, in particular to a kind of preparation for improving endocrine integration of drinking and medicinal herbs
And preparation method thereof.
Background technique
Human body has endocrine system, secretes metabolism and physiological function that various hormones and nervous system adjust human body together.
Various hormones are to maintain balance under normal circumstances, such as because certain reason makes this balance break (certain hormonosis or mistake
This results in endocrine disorder less), can cause corresponding clinical manifestation.Male and female are all likely to occur endocrine disorder.Summer
It is especially hot, it is easy to which consumption hurts women qi and blood, leads to endocrine disorder, viscera function disorder, qi depression to blood stasis.
Summary of the invention
The purpose of the present invention is to provide a kind of preparations and preparation method thereof for improving endocrine integration of drinking and medicinal herbs, on solving
The problem of stating.
A kind of preparation improving endocrine integration of drinking and medicinal herbs, compositing formula are as follows: hawthorn, lily, Radix Angelicae Sinensis, rhizoma polygonati, lotus seeds, mountain
Medicine, raspberry, peach kernel, Radix Codonopsis, dendrobium candidum, Radix Astragali, Rhizoma Chuanxiong and auxiliary material are refined into tablet, particle by each dosage formulation requirement
Agent, pill, capsule or mixture.
Preferably, the preparation of the conditioning endocrine integration of drinking and medicinal herbs is made of following raw material based on parts by weight: mountain
30~55 parts of short, bristly hair or beard, 25~50 parts of lily, 90~110 parts of Radix Angelicae Sinensis, 90~110 parts of rhizoma polygonati, 70~90 parts of raspberry, lotus seeds 35~60
Part, 50~85 parts of Chinese yam, 20~45 parts of peach kernel, 35~60 parts of Radix Codonopsis, 20~40 parts of dendrobium candidum, 30~60 parts of Radix Astragali, Rhizoma Chuanxiong
35~60 parts and auxiliary material.
It is highly preferred that the preparation of the conditioning endocrine integration of drinking and medicinal herbs is made of following raw material based on parts by weight:
35~45 parts of hawthorn, 30~45 parts of lily, 90~100 parts of Radix Angelicae Sinensis, 95~110 parts of rhizoma polygonati, 75~90 parts of raspberry, lotus seeds 35~
50 parts, 60~75 parts of Chinese yam, 20~45 parts of peach kernel, 40~60 parts of Radix Codonopsis, 25~40 parts of dendrobium candidum, 35~50 parts of Radix Astragali, river
45~55 parts of rhizome of chuanxiong and auxiliary material.
Preferably, the auxiliary material includes sugar and filler.
Preferably, the sugar is one of sucrose, brown sugar or brown sugar, and additive amount is 25~45 parts；The filling
Agent is one of maltodextrin or microcrystalline cellulose, and additive amount is 1~5 part.
Preferably, the preparation method of the preparation of the conditioning endocrine integration of drinking and medicinal herbs, which is characterized in that include following step
It is rapid:
S1. prepare related medicinal material by above-mentioned formula, medicinal material is selected and is cleaned, and various medicinal materials are carried out in proportion
Mixing；
S2. the medicinal material mixed is impregnated with 100~200L drinking water, soaking temperature is 20~30 DEG C, when immersion
Between be 20~45min；
When S3. impregnating, the container for impregnating medicinal material is put into ultrasound and is shaken；
It when S4. extracting, then toward addition 500~650L drinking water in medicinal material, is decocted, the time is 1.5~2h, is received simultaneously
Collect volatile oil；
S5. then, medical fluid and the dregs of a decoction are separated, collects medical fluid；The drinking water of 350~500L is added into filter residue again, into
Row decocts, and the time is 2~3h, is collected simultaneously volatile oil；
S6. above-mentioned filtrate and filter residue are separated, takes filtrate, abandon filter residue；And the medical fluid extracted twice is mixed；
S7. by above-mentioned gained medical filtration, be concentrated into relative density be 1.12 ± 0.05 clear cream；
S8. 2/3 part of clear cream spray drying tower therein is taken, 160~180 DEG C of inlet air temperature, 80~100 DEG C of leaving air temp
It is spraying to obtain extract powder at powder；
S9. remaining takes 1/3 part of clear cream to make adhesive, using extract powder as parent nucleus, is pelletized with one-step-granulating method, inlet air temperature
60~80 DEG C, 40~70 DEG C of leaving air temp, obtain particle；
S10. volatile oil is added to stew to moisten, with rotary tablet press, obtains product.
Preferably, the preparation method of the preparation of the conditioning endocrine integration of drinking and medicinal herbs, production tablet comprise the steps of:
S1. prepare related medicinal material by above-mentioned formula, medicinal material is selected and is cleaned, and various medicinal materials are carried out in proportion
Mixing；
S2. the medicinal material mixed is impregnated with 100~200L drinking water, soaking temperature is 20~30 DEG C, when immersion
Between be 20~45min；
When S3. impregnating, the container for impregnating medicinal material is put into ultrasound and is shaken；
It when S4. extracting, then toward addition 500~650L drinking water in medicinal material, is decocted, the time is 1.5~2h, is received simultaneously
Collect volatile oil；
S5. then, medical fluid and the dregs of a decoction are separated, collects medical fluid；The drinking water of 350~500L is added into filter residue again, into
Row decocts, and the time is 2~3h, is collected simultaneously volatile oil；
S6. above-mentioned filtrate and filter residue are separated, takes filtrate, abandon filter residue；And the medical fluid extracted twice is mixed；
S7. Three-effect energy-saving inspissator, 80 DEG C of a temperature of effect, two effect 70 DEG C, three will be used after 200 mesh screens of gained medical fluid
It is 1.12 ± 0.05 that 60 DEG C of effect, which is concentrated into relative density, obtains medicinal extract；
S8. 2/3 part of clear cream spray drying tower therein is taken, 160~180 DEG C of inlet air temperature, 80~100 DEG C of leaving air temp
It is spraying to obtain extract powder at powder；
S9. remaining takes 1/3 part of clear cream to make adhesive, using extract powder as parent nucleus, is pelletized with one-step-granulating method, inlet air temperature
60~80 DEG C, 40~70 DEG C of leaving air temp, obtain particle；
S10. volatile oil is added to stew to moisten, with rotary tablet press, every 0.4g, coating, packing obtain product.
Preferably, the preparation method of the preparation of the conditioning endocrine integration of drinking and medicinal herbs, production particle electuary include following
Step:
S1. prepare related medicinal material by above-mentioned formula, medicinal material is selected and is cleaned, and various medicinal materials are carried out in proportion
Mixing；
S2. the medicinal material mixed is impregnated with 100~200L drinking water, soaking temperature is 20~30 DEG C, when immersion
Between be 20~45min；
When S3. impregnating, the container for impregnating medicinal material is put into ultrasound and is shaken；
It when S4. extracting, then toward addition 500~650L drinking water in medicinal material, is decocted, the time is 1.5~2h, is received simultaneously
Collect volatile oil；
S5. then, medical fluid and the dregs of a decoction are separated, collects medical fluid；The drinking water of 350~500L is added into filter residue again, into
Row decocts, and the time is 2~3h, is collected simultaneously volatile oil；
S6. above-mentioned filtrate and filter residue are separated, takes filtrate, abandon filter residue；And the medical fluid extracted twice is mixed；
S7. Three-effect energy-saving inspissator, 80 DEG C of a temperature of effect, two effect 70 DEG C, three will be used after 200 mesh screens of gained medical fluid
It is 1.12 ± 0.05 that 60 DEG C of effect, which is concentrated into relative density, obtains medicinal extract；
S8. 2/3 part of clear cream spray drying tower therein is taken, 160~180 DEG C of inlet air temperature, 80~100 DEG C of leaving air temp
It is spraying to obtain extract powder at powder；
S9. it is pelletized with one-step-granulating method, 60~80 DEG C of inlet air temperature, 40~70 DEG C of leaving air temp obtain particle；It is added and collects
The volatile oil arrived stews to moisten overnight, is distributed into 3g/ bags with particle packaging machine, obtains product.
Preferably, the preparation method of the preparation, preparing pill includes:
Above-mentioned formula herbs were ground into 100 targeted fine powders with pulverizer；Make adhesive with honey, softwood be made,
Ball is made with pellet processing machine；Low temperature drying is distributed into 100g/ bottles, obtains finished product.
Preferably, the preparation method of the preparation of the conditioning endocrine integration of drinking and medicinal herbs, production capsule step include:
S1. prepare related medicinal material by above-mentioned formula, medicinal material is selected and is cleaned, and various medicinal materials are carried out in proportion
Mixing；
S2. the medicinal material mixed is impregnated with 100~200L drinking water, soaking temperature is 20~30 DEG C, when immersion
Between be 20~45min；
When S3. impregnating, the container for impregnating medicinal material is put into ultrasound and is shaken；
It when S4. extracting, then toward addition 500~650L drinking water in medicinal material, is decocted, the time is 1.5~2h, is received simultaneously
Collect volatile oil；
S5. then, medical fluid and the dregs of a decoction are separated, collects medical fluid；The drinking water of 350~500L is added into filter residue again, into
Row decocts, and the time is 2~3h, is collected simultaneously volatile oil；
S6. above-mentioned filtrate and filter residue are separated, takes filtrate, abandon filter residue；And the medical fluid extracted twice is mixed；
S7. Three-effect energy-saving inspissator, 80 DEG C of a temperature of effect, two effect 70 DEG C, three will be used after 200 mesh screens of gained medical fluid
It is 1.12 ± 0.05 that 60 DEG C of effect, which is concentrated into relative density, obtains medicinal extract；
S8. 2/3 part of clear cream spray drying tower therein is taken, 160~180 DEG C of inlet air temperature, 80~100 DEG C of leaving air temp
It is spraying to obtain extract powder at powder；
S9. remaining takes 1/3 part of clear cream to make adhesive, using extract powder as parent nucleus, is pelletized with one-step-granulating method, inlet air temperature
60~80 DEG C, 40~70 DEG C of leaving air temp, obtain particle；
S10. the volatile oil being collected into is added, stews to moisten overnight, is filled into 0.5g/ with capsule filling machine；Be distributed at
Product.
Preferably, the preparation method of the preparation of the conditioning endocrine integration of drinking and medicinal herbs, production mixture step include:
S1. prepare related medicinal material by above-mentioned formula, medicinal material is selected and is cleaned, and various medicinal materials are carried out in proportion
Mixing；
S2. the medicinal material mixed is impregnated with 100~200L drinking water, soaking temperature is 20~30 DEG C, when immersion
Between be 20~45min；
When S3. impregnating, the container for impregnating medicinal material is put into ultrasound and is shaken；
It when S4. extracting, then toward addition 500~650L drinking water in medicinal material, is decocted, the time is 1.5~2h, is received simultaneously
Collect volatile oil；
S5. then, medical fluid and the dregs of a decoction are separated, collects medical fluid；The drinking water of 350~500L is added into filter residue again, into
Row decocts, and the time is 2~3h, is collected simultaneously volatile oil；
S6. above-mentioned filtrate and filter residue are separated, takes filtrate, abandon filter residue；And the medical fluid extracted twice is mixed；
S7. Three-effect energy-saving inspissator, 80 DEG C of a temperature of effect, two effect 70 DEG C, three will be used after 200 mesh screens of gained medical fluid
It is 1.12 ± 0.05 that 60 DEG C of effect, which is concentrated into relative density, obtains medicinal extract；
S8. made the range of alcohol content 50~70% with 95% ethyl alcohol alcohol precipitation again, stood overnight, take supernatant, recycle second
Alcohol is prepared to no alcohol taste, the volatile oil and appropriate syrup, essence of collection is added；
S9. filling at 10ml/ bottles with bottle placer, mounted box, 10 bottles of every box obtains finished product.
Chinese medicine thinks that endocrine disorder is the performance of the deficiency of Yin, is caused by being retarded by silt as qi and blood.Extravasated blood is detained internal, train of thought
It is obstructed, outer malicious human body, lochiostasis etc. of invading may all be led to that qi and blood is retarded by silt.Many women common diseases are all in fact
Due to caused by endocrine disorder.Therefore, these illnesss are treated, to be started with from endocrine is adjusted, be enabled qi and blood unobstructed, grow essence and blood
Whole body is supported, is promoted blood circulation, comprehensive conditioning from inside to outside.According to the diagnosis and treatment based on an overall analysis of the illness and the patient's condition principle of Chinese medicine, hyperfunction person is answered
It is pay attention to yin-nourishing and treating more, and qi-blood deficiency, kidney deficiency etc. is often presented with for hypothyroid, conventional therapy is with selenium-rich Six-element
Dihuang Wan conditioning is to give enriching the blood and tonifying qi, and kidney and spleen invigorating safely and effectively adjusts endocrine.And the present invention passes through between each drug
Synergistic effect, play replenishing vital essence and invigorating vital QI, blood circulation promoting and enriching, relax meridian and relieving pain, kidney and spleen invigorating, moistening the lung and nourish yin the effect of, can be internal
Secretion is improved, and endocrine is made to restore normal, dysmenorrhea, freckle, fatigue etc. caused by also making simultaneously because of endocrine disorder
Symptom disappears, significant effect.
Specific embodiment
The present invention is further elaborated combined with specific embodiments below, the embodiment is served only for explaining this hair
It is bright, it is not intended to limit the scope of the present invention.Test method as used in the following examples is routine unless otherwise specified
Method；Used material, reagent etc., unless otherwise specified, for the reagent and material commercially obtained.
Embodiment one
It is a kind of improve endocrine integration of drinking and medicinal herbs preparation be made of following raw material based on parts by weight:
32 parts of hawthorn, 26 parts of lily, 91 parts of Radix Angelicae Sinensis, 92 parts of rhizoma polygonati, 73 parts of raspberry, 38 parts of lotus seeds, 52 parts of Chinese yam, peach kernel
23 parts, 35 parts of Radix Codonopsis, 22 parts of dendrobium candidum, 30 parts of Radix Astragali, 35 parts of Rhizoma Chuanxiong, 30 parts of sucrose and 3 parts of maltodextrin.
The preparation method of the preparation of the conditioning endocrine integration of drinking and medicinal herbs, production tablet comprise the steps of:
S1. prepare related medicinal material by above-mentioned formula, medicinal material is selected and is cleaned, and various medicinal materials are carried out in proportion
Mixing；
S2. the medicinal material mixed is impregnated with 120L drinking water, soaking temperature is 25 DEG C, soaking time 20min；
When S3. impregnating, the container for impregnating medicinal material is put into ultrasound and is shaken；
When S4. extracting, then toward addition 500L drinking water in medicinal material, decocted, time 1.5h is collected simultaneously volatilization
Oil；
S5. then, medical fluid and the dregs of a decoction are separated, collects medical fluid；350 drinking water is added into filter residue again, is decocted,
Time is 2h, is collected simultaneously volatile oil；
S6. above-mentioned filtrate and filter residue are separated, takes filtrate, abandon filter residue；And the medical fluid extracted twice is mixed；
S7. Three-effect energy-saving inspissator, 80 DEG C of a temperature of effect, two effect 70 DEG C, three will be used after 200 mesh screens of gained medical fluid
It is 1.12 ± 0.05 that 60 DEG C of effect, which is concentrated into relative density, obtains medicinal extract；
S8. 2/3 part of clear cream spray drying tower therein is taken, 160~180 DEG C of inlet air temperature, 80~100 DEG C of leaving air temp
It is spraying to obtain extract powder at powder；
S9. remaining takes 1/3 part of clear cream to make adhesive, using extract powder as parent nucleus, is pelletized with one-step-granulating method, inlet air temperature
60~80 DEG C, 40~70 DEG C of leaving air temp, obtain particle；
S10. volatile oil is added to stew to moisten, with rotary tablet press, every 0.4g, coating, packing obtain product.
Embodiment two
It is a kind of improve endocrine integration of drinking and medicinal herbs preparation be made of following raw material based on parts by weight:
30~55 parts of hawthorn, 25~50 parts of lily, 90~110 parts of Radix Angelicae Sinensis, 90~110 parts of rhizoma polygonati, 70~90 parts of raspberry,
35~60 parts of lotus seeds, 50~85 parts of Chinese yam, 20~45 parts of peach kernel, 35~60 parts of Radix Codonopsis, 20~40 parts of dendrobium candidum, Radix Astragali 30~
60 parts, 55 parts of Rhizoma Chuanxiong, 42 parts of brown sugar and 5 parts of maltodextrin.
A kind of preparation method for the preparation improving endocrine integration of drinking and medicinal herbs, production particle electuary comprise the steps of:
S1. prepare related medicinal material by above-mentioned formula, medicinal material is selected and is cleaned, and various medicinal materials are carried out in proportion
Mixing；
S2. the medicinal material mixed is impregnated with 150L drinking water, soaking temperature is 25 DEG C, soaking time 32min；
When S3. impregnating, the container for impregnating medicinal material is put into ultrasound and is shaken；
When S4. extracting, then toward addition 550L drinking water in medicinal material, decocted, time 1.5h is collected simultaneously volatilization
Oil；
S5. then, medical fluid and the dregs of a decoction are separated, collects medical fluid；The drinking water of 425L is added into filter residue again, carries out pan-fried
It boils, time 2.5h is collected simultaneously volatile oil；
S6. above-mentioned filtrate and filter residue are separated, takes filtrate, abandon filter residue；And the medical fluid extracted twice is mixed；
S7. Three-effect energy-saving inspissator, 80 DEG C of a temperature of effect, two effect 70 DEG C, three will be used after 200 mesh screens of gained medical fluid
It is 1.12 ± 0.05 that 60 DEG C of effect, which is concentrated into relative density, obtains medicinal extract；
S8. 2/3 part of clear cream spray drying tower therein is taken, 160~180 DEG C of inlet air temperature, 80~100 DEG C of leaving air temp
It is spraying to obtain extract powder at powder；
S9. it is pelletized with one-step-granulating method, 60~80 DEG C of inlet air temperature, 40~70 DEG C of leaving air temp obtain particle；It is added and collects
The volatile oil arrived stews to moisten overnight, is distributed into 3g/ bags with particle packaging machine, obtains product.
Embodiment three
It is a kind of improve endocrine integration of drinking and medicinal herbs preparation be made of following raw material based on parts by weight:
35 parts of hawthorn, 30 parts of lily, 96 parts of Radix Angelicae Sinensis, 98 parts of rhizoma polygonati, 75 parts of raspberry, 45 parts of lotus seeds, 62 parts of Chinese yam, peach kernel
30 parts, 45 parts of Radix Codonopsis, 25 parts of dendrobium candidum, 42 parts of Radix Astragali, 45 parts of Rhizoma Chuanxiong, 42 parts of brown sugar and 2 parts of microcrystalline cellulose.
A kind of preparation method for the preparation improving endocrine integration of drinking and medicinal herbs, production pill comprise the steps of:
Above-mentioned formula herbs were ground into 100 targeted fine powders with pulverizer；Make adhesive with honey, softwood be made,
Ball is made with pellet processing machine；Low temperature drying is distributed into 100g/ bottles, obtains finished product.
Example IV
It is a kind of improve endocrine integration of drinking and medicinal herbs preparation be made of following raw material based on parts by weight:
35 parts of hawthorn, 40 parts of lily, 105 parts of Radix Angelicae Sinensis, 93 parts of rhizoma polygonati, 85 parts of raspberry, 45 parts of lotus seeds, 68 parts of Chinese yam, peach
38 parts of benevolence, 46 parts of Radix Codonopsis, 32 parts of dendrobium candidum, 52 parts of Radix Astragali, 50 parts of Rhizoma Chuanxiong, 40 parts of brown sugar, 3 parts of microcrystalline cellulose.
A kind of preparation method for the preparation improving endocrine integration of drinking and medicinal herbs, production capsule step include:
S1. prepare related medicinal material by above-mentioned formula, medicinal material is selected and is cleaned, and various medicinal materials are carried out in proportion
Mixing；
S2. the medicinal material mixed is impregnated with 175L drinking water, soaking temperature is 28 DEG C, soaking time 36min；
When S3. impregnating, the container for impregnating medicinal material is put into ultrasound and is shaken；
When S4. extracting, then toward addition 625L drinking water in medicinal material, decocted, time 2h is collected simultaneously volatile oil；
S5. then, medical fluid and the dregs of a decoction are separated, collects medical fluid；The drinking water of 425L is added into filter residue again, carries out pan-fried
It boils, time 2.5h is collected simultaneously volatile oil；
S6. above-mentioned filtrate and filter residue are separated, takes filtrate, abandon filter residue；And the medical fluid extracted twice is mixed；
S7. Three-effect energy-saving inspissator, 80 DEG C of a temperature of effect, two effect 70 DEG C, three will be used after 200 mesh screens of gained medical fluid
It is 1.12 ± 0.05 that 60 DEG C of effect, which is concentrated into relative density, obtains medicinal extract；
S8. 2/3 part of clear cream spray drying tower therein is taken, 160~180 DEG C of inlet air temperature, 80~100 DEG C of leaving air temp
It is spraying to obtain extract powder at powder；
S9. remaining takes 1/3 part of clear cream to make adhesive, using extract powder as parent nucleus, is pelletized with one-step-granulating method, inlet air temperature
60~80 DEG C, 40~70 DEG C of leaving air temp, obtain particle；
S10. the volatile oil being collected into is added, stews to moisten overnight, is filled into 0.5g/ with capsule filling machine；Be distributed at
Product.
Embodiment five
It is a kind of improve endocrine integration of drinking and medicinal herbs preparation be made of following raw material based on parts by weight:
32 parts of hawthorn, 40 parts of lily, 96 parts of Radix Angelicae Sinensis, 100 parts of rhizoma polygonati, 81 parts of raspberry, 52 parts of lotus seeds, 83 parts of Chinese yam, peach
42 parts of benevolence, 53 parts of Radix Codonopsis, 36 parts of dendrobium candidum, 60 parts of Radix Astragali, 52 parts of Rhizoma Chuanxiong, 43 parts of sucrose and 5 parts of maltodextrin.
A kind of preparation method for the preparation improving endocrine integration of drinking and medicinal herbs, production mixture step include:
S1. prepare related medicinal material by above-mentioned formula, medicinal material is selected and is cleaned, and various medicinal materials are carried out in proportion
Mixing；
S2. the medicinal material mixed is impregnated with 150L drinking water, soaking temperature is 30 DEG C, soaking time 40min；
When S3. impregnating, the container for impregnating medicinal material is put into ultrasound and is shaken；
When S4. extracting, then toward addition 525L drinking water in medicinal material, decocted, time 1.5h is collected simultaneously volatilization
Oil；
S5. then, medical fluid and the dregs of a decoction are separated, collects medical fluid；The drinking water of 450L is added into filter residue again, carries out pan-fried
It boils, time 3h is collected simultaneously volatile oil；
S6. above-mentioned filtrate and filter residue are separated, takes filtrate, abandon filter residue；And the medical fluid extracted twice is mixed；
S7. Three-effect energy-saving inspissator, 80 DEG C of a temperature of effect, two effect 70 DEG C, three will be used after 200 mesh screens of gained medical fluid
It is 1.12 ± 0.05 that 60 DEG C of effect, which is concentrated into relative density, obtains medicinal extract；
S8. made the range of alcohol content 50~70% with 95% ethyl alcohol alcohol precipitation again, stood overnight, take supernatant, recycle second
Alcohol is prepared to no alcohol taste, the volatile oil and appropriate syrup, essence of collection is added；
S9. filling at 10ml/ bottles with bottle placer, mounted box, 10 bottles of every box obtains finished product.
One, clinical treatment
Product of the present invention observes case 120 altogether, wherein treatment group 80, control group 40, and observe result: treatment group is aobvious
Efficiency 60.57%, control group obvious effective rate 45.33%, is statistically analyzed, and there were significant differences for the two, and treatment group is better than control group,
Meanwhile not finding that the medicine has obvious adverse reaction.Now clinical study results are summarized as follows:
General information
Selection primary dysmenorrhea patient 120, (being outpatient) is randomly divided into treatment group and control group, the middle age
It is age minimum 18 years old, 32 years old maximum, 21.2 years old average, the course of disease most short March, longest 4 years, treatment group 80 and control group 40 it
Between, above-mentioned data is statistically analyzed P > 0.05, shows that the two is comparable, full edition omits.
Case selection
1, diagnostic criteria is formulated referring to " guideline of clinical investigations of new Chinese medicine treatment dysmenorrhea ".
Patient clinical symptom are as follows: the intensely dark pool of skin, loose, pore is coarse, face has a large amount of or do not meet in flakes
The color spot at age；It is menstruation irregularis, dysmenorrhea, in poor health, heavy, liable to illness.
2, treatment method
2 times a day, each 8g continuously takes 3 weeks.
3, criterion of therapeutical effect
Effective: each clinical symptoms such as color spot, irregular menstruation are completely disappeared or are disappeared substantially, and endocrine restores normal；
Effective: each clinical symptoms such as color spot, irregular menstruation take an evident turn for the better, and endocrine disorder makes moderate progress；
Invalid: endocrine disorder, each clinical symptoms are without improvement.
4, experimental result
According to statistics, effect of 120 patients after using drug of the present invention 3 weeks is as follows and uneasy to recur:
Treatment group is compared with control group total effects, and data are as shown in table 1 (Ridit inspection)
1 medicining condition of table statistics
Show to be statistically analyzed therebetween by upper table, has significant difference (P < 0.02), treatment group's curative effect is better than
Control group.
Adverse reaction
There are 3 patients nausea occur at medication initial stage in treatment group 80, but symptom is slight, disappears, is not necessarily to after continuing medication
There are no be not resistant to and drug withdrawal person for processing.Liver and kidney function exception person is not found.
Brief summary
Most patients were having apparent feeling, pigmentation face using drug 1 week or so according to the method for the present invention
Discoloration is shallow, and a small number of spots disappear or become smaller, and skin color improves, and physical condition improves.
Two, animal experiment
Test material: by a kind of preparation for improving endocrine integration of drinking and medicinal herbs prepared by preparation method of the present invention；It is commercially available certain control
Treat the particle of dysmenorrhea.
1, analgesic activity:
Test grouping: healthy mice 50,200 ± 2g of weight are taken, and mouse is randomly divided into 5 groups, every group 10.
Trial drug dosage: positive controls: the particle 10g/kg (concentration 50%) of certain commercially available treatment dysmenorrhea；It is high, medium and low
The preparation 0.8g/ according to conditioning endocrine integration of drinking and medicinal herbs prepared by preparation method of the present invention is given in stomach-filling to the administration group of dosage respectively
0.4ml/20g is pressed in kg, 1.6g/kg, 3.2g/kg (concentration is respectively 4%, 8%, 16%), administration；Blank group: stomach-filling is given
The water of volume.1 time a day, successive administration 3 days.
(1), oxytocins induces dysmenorrhea model in mice:
Test method: healthy mice 50, each group intragastric administration on mice gives diethylstilbestrol, once a day, each 2mg/kg, and even
After continuous 10 days, the 11st day beginning each group mouse gives diethylstilbestrol afternoon, each 2mg/kg, meanwhile, positive controls give city
Sell certain treatment dysmenorrhea particle, the administration group of three dosage respectively stomach-filling give conditioning endocrine integration of drinking and medicinal herbs preparation, continuous 3
It, ip oxytocins 20u/kg after last dose 30min observes and records writhing incubation period and writhing number in each group mouse 30min
(test data is as shown in table 2).
Table 2 induces oxytocins the influence of dysmenorrhea model in mice writhing response
| Group | Writhing latent time | Writhing number |
| Blank control group | 2.7±0.55 | 60.15±8.23 |
| Positive controls | 3.2±0.68 | 52.25±7.15 |
| High dose group | 4.5±0.63 | 31.15±6.29 |
| Middle dose group | 3.9±0.82 | 38.19±7.45 |
| Low dose group | 3.6±0.61 | 40.75±8.23 |
It can be seen from the data in table 2 compared with blank control group, the writhing latent time of the mouse of other each groups is all
It is significantly increased, writhing number is reduced, this shows that the anti-pain ability of other 4 groups of mouse has enhancing, and analgesic effect is more preferable；
Secondly, the writhing of the mouse of the preparation of stomach-filling conditioning endocrine integration of drinking and medicinal herbs prepared by the present invention is latent compared with positive controls
The volt time is longer, and writhing number is less, the mouse of the preparation of this display stomach-filling conditioning endocrine integration of drinking and medicinal herbs prepared by the present invention
Analgesic effect it is more preferable, show it is prepared by the present invention conditioning endocrine integration of drinking and medicinal herbs preparation for alleviate mouse dysmenorrhea effect
More significant, anti-pain effect is more preferable.
2, activating microcirculation and removing stasis medicinal is tested
Test grouping: healthy mice 40,200 ± 2g of weight are taken, and mouse is randomly divided into 5 groups, every group 8.
Experimental method
The normal group conventinal breeding of model preparation, (stomach-filling is given according to prepared by preparation method of the present invention for model group, treatment group
Improving the preparation of endocrine integration of drinking and medicinal herbs) mouse is placed in 5min in 0 DEG C~1 DEG C ice water, one time a day, continuous seven days.Treatment group in
The 1st day of modeling starts, and the preparation of conditioning endocrine integration of drinking and medicinal herbs prepared by the present invention is used in conjunction 7 days, and normal group, model group gives
Give the processing of physiological saline same method.In the 8th day subcutaneous injection 0.1% adrenaline 0.1ml/100g, totally 2 times, two minor ticks
Time 4h.Stop eating later, instrument measurement Hemorheology index is surveyed using full-automatic rheology fastly in morning；Using radio-immunity
Method measurement serum in hormonal readiness.
Animal packet selection female rats 80, age of mouse 3.5 months, weight 200g ± 5g.After adaptive feeding 1 week, press
Random digits table is classified as 5 groups, every group 8, i.e., Normal group (normal group), model control group (model group), according to
The preparation low dose group (0.6g/kg) of conditioning endocrine integration of drinking and medicinal herbs prepared by preparation method of the present invention is prepared according to the present invention
Method preparation conditioning endocrine integration of drinking and medicinal herbs preparation middle dose group (1.2g/kg) and according to prepared by preparation method of the present invention
Improve the preparation large dosage group (2.4g/kg) of endocrine integration of drinking and medicinal herbs.Normal group gives physiological saline.It is multiple according to the above method
Cold blood stasis rat model processed.The 60min after last medication, arteria carotis take blood, and (test result is such as measurement hemorheology index
Shown in table 3, using control group blood viscosity as benchmark data 100%).
3 mouse activating microcirculation and removing stasis medicinal of table test
| Group | Dosage | Blood viscosity |
| Control group | Same volume physiological saline | 100% |
| Model group | Same volume physiological saline | 130% |
| Low dose group | 0.6 | 125% |
| Middle dose group | 1.2 | 115% |
| High dose group | 2.4 | 102% |
It can be seen from 3 data of table compared with the control group, the blood viscosity of model group obviously rises, this show modeling at
Function, compared with model group, 3 groups of the preparation according to conditioning endocrine integration of drinking and medicinal herbs prepared by preparation method of the present invention are given in stomach-filling
The blood viscosity of mouse be decreased obviously, this shows that its blood stasis situation has obtained apparent alleviation, and upper with dose concentration
It rises, blood viscosity has been approached control group, this shows the system according to conditioning endocrine integration of drinking and medicinal herbs prepared by preparation method of the present invention
Agent has preferable function of promoting blood circulation to disperse blood clots.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than the present invention is protected
The limitation of range is protected, although explaining in detail referring to preferred embodiment to the present invention, those skilled in the art are answered
Work as understanding, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the reality of technical solution of the present invention
Matter and range.
Claims (10)
1. a kind of preparation for improving endocrine integration of drinking and medicinal herbs, which is characterized in that compositing formula is as follows: hawthorn, lily, Radix Angelicae Sinensis, Huang
Essence, lotus seeds, Chinese yam, raspberry, peach kernel, Radix Codonopsis, dendrobium candidum, Radix Astragali, Rhizoma Chuanxiong and auxiliary material are refined by each dosage formulation requirement
Tablet, granule, pill, capsule or mixture.
2. a kind of preparation for improving endocrine integration of drinking and medicinal herbs according to claim 1, which is characterized in that with parts by weight
Meter, be made of following raw material: 30~55 parts of hawthorn, 90~110 parts of Radix Angelicae Sinensis, 90~110 parts of rhizoma polygonati, covers basin at 25~50 parts of lily
Sub 70~90 parts, 35~60 parts of lotus seeds, 50~85 parts of Chinese yam, 20~45 parts of peach kernel, 35~60 parts of Radix Codonopsis, dendrobium candidum 20~40
Part, 30~60 parts of Radix Astragali, 35~60 parts of Rhizoma Chuanxiong and auxiliary material.
3. a kind of preparation for improving endocrine integration of drinking and medicinal herbs according to claim 1, which is characterized in that with parts by weight
Meter, be made of following raw material: 35~45 parts of hawthorn, 90~100 parts of Radix Angelicae Sinensis, 95~110 parts of rhizoma polygonati, covers basin at 30~45 parts of lily
Sub 75~90 parts, 35~50 parts of lotus seeds, 60~75 parts of Chinese yam, 20~45 parts of peach kernel, 40~60 parts of Radix Codonopsis, dendrobium candidum 25~40
Part, 35~50 parts of Radix Astragali, 45~55 parts of Rhizoma Chuanxiong and auxiliary material.
4. a kind of preparation for improving endocrine integration of drinking and medicinal herbs according to claim 3, which is characterized in that the auxiliary material
Including sugar and filler.
5. a kind of preparation for improving endocrine integration of drinking and medicinal herbs according to claim 4, which is characterized in that the sugar is sugarcane
One of sugar, brown sugar or brown sugar, additive amount are 25~45 parts；The filler is in maltodextrin or microcrystalline cellulose
One kind, additive amount are 1~5 part.
6. the preparation method of the preparation of described in any item conditioning endocrine integration of drinking and medicinal herbs, feature exist according to claim 1~3
In comprising the steps of:
S1. prepare related medicinal material by above-mentioned formula, medicinal material is selected and is cleaned, and various medicinal materials are mixed in proportion
It closes；
S2. the medicinal material mixed is impregnated with 100~200L drinking water, soaking temperature is 20~30 DEG C, and soaking time is
20~45min；
When S3. impregnating, the container for impregnating medicinal material is put into ultrasound and is shaken；
It when S4. extracting, then toward addition 500~650L drinking water in medicinal material, is decocted, the time is 1.5~2h, is collected simultaneously and waves
Hair oil；
S5. then, medical fluid and the dregs of a decoction are separated, collects medical fluid；The drinking water of 350~500L is added into filter residue again, carries out pan-fried
It boils, the time is 2~3h, is collected simultaneously volatile oil；
S6. above-mentioned filtrate and filter residue are separated, takes filtrate, abandon filter residue；And the medical fluid extracted twice is mixed；
S7. by above-mentioned gained medical filtration, be concentrated into relative density be 1.12 ± 0.05 clear cream；
S8. 2/3 part of clear cream spray drying tower therein is taken, 160~180 DEG C of inlet air temperature, 80~100 DEG C of leaving air temp spraying
Extract powder is obtained at powder；
S9. remaining takes 1/3 part of clear cream to make adhesive, using extract powder as parent nucleus, is pelletized with one-step-granulating method, and inlet air temperature 60~
80 DEG C, 40~70 DEG C of leaving air temp, obtain particle；
S10. volatile oil is added to stew to moisten, with rotary tablet press, obtains product.
7. the preparation method of the preparation of described in any item conditioning endocrine integration of drinking and medicinal herbs according to claim 1~3, makes tablet
It comprises the steps of:
S1. prepare related medicinal material by above-mentioned formula, medicinal material is selected and is cleaned, and various medicinal materials are mixed in proportion
It closes；
S2. the medicinal material mixed is impregnated with 100~200L drinking water, soaking temperature is 20~30 DEG C, and soaking time is
20~45min；
When S3. impregnating, the container for impregnating medicinal material is put into ultrasound and is shaken；
It when S4. extracting, then toward addition 500~650L drinking water in medicinal material, is decocted, the time is 1.5~2h, is collected simultaneously and waves
Hair oil；
S5. then, medical fluid and the dregs of a decoction are separated, collects medical fluid；The drinking water of 350~500L is added into filter residue again, carries out pan-fried
It boils, the time is 2~3h, is collected simultaneously volatile oil；
S6. above-mentioned filtrate and filter residue are separated, takes filtrate, abandon filter residue；And the medical fluid extracted twice is mixed；
S7. Three-effect energy-saving inspissator, 80 DEG C of a temperature of effect, two effect 70 DEG C, triple effects 60 will be used after 200 mesh screens of gained medical fluid
DEG C being concentrated into relative density is 1.12 ± 0.05, obtains medicinal extract；
S8. 2/3 part of clear cream spray drying tower therein is taken, 160~180 DEG C of inlet air temperature, 80~100 DEG C of leaving air temp spraying
Extract powder is obtained at powder；
S9. remaining takes 1/3 part of clear cream to make adhesive, using extract powder as parent nucleus, is pelletized with one-step-granulating method, and inlet air temperature 60~
80 DEG C, 40~70 DEG C of leaving air temp, obtain particle；
S10. volatile oil is added to stew to moisten, with rotary tablet press, every 0.4g, coating, packing obtain product.
8. the preparation method of the preparation of described in any item conditioning endocrine integration of drinking and medicinal herbs according to claim 1~3, makes particle
Electuary comprises the steps of:
S1. prepare related medicinal material by above-mentioned formula, medicinal material is selected and is cleaned, and various medicinal materials are mixed in proportion
It closes；
S2. the medicinal material mixed is impregnated with 100~200L drinking water, soaking temperature is 20~30 DEG C, and soaking time is
20~45min；
When S3. impregnating, the container for impregnating medicinal material is put into ultrasound and is shaken；
It when S4. extracting, then toward addition 500~650L drinking water in medicinal material, is decocted, the time is 1.5~2h, is collected simultaneously and waves
Hair oil；
S5. then, medical fluid and the dregs of a decoction are separated, collects medical fluid；The drinking water of 350~500L is added into filter residue again, carries out pan-fried
It boils, the time is 2~3h, is collected simultaneously volatile oil；
S6. above-mentioned filtrate and filter residue are separated, takes filtrate, abandon filter residue；And the medical fluid extracted twice is mixed；
S7. Three-effect energy-saving inspissator, 80 DEG C of a temperature of effect, two effect 70 DEG C, triple effects 60 will be used after 200 mesh screens of gained medical fluid
DEG C being concentrated into relative density is 1.12 ± 0.05, obtains medicinal extract；
S8. 2/3 part of clear cream spray drying tower therein is taken, 160~180 DEG C of inlet air temperature, 80~100 DEG C of leaving air temp spraying
Extract powder is obtained at powder；
S9. it is pelletized with one-step-granulating method, 60~80 DEG C of inlet air temperature, 40~70 DEG C of leaving air temp obtain particle；What addition was collected into
Volatile oil stews to moisten overnight, is distributed into 3g/ bags with particle packaging machine, obtains product.
9. the preparation method of the preparation of described in any item conditioning endocrine integration of drinking and medicinal herbs, feature exist according to claim 1~3
In preparing pill includes:
Above-mentioned formula herbs were ground into 100 targeted fine powders with pulverizer；Make adhesive with honey, softwood is made, with system
Ball mechanism pelletization；Low temperature drying is distributed into 100g/ bottles, obtains finished product.
10. the preparation method of the preparation of described in any item conditioning endocrine integration of drinking and medicinal herbs according to claim 1~3, makes glue
Wafer step includes:
S1. prepare related medicinal material by above-mentioned formula, medicinal material is selected and is cleaned, and various medicinal materials are mixed in proportion
It closes；
S2. the medicinal material mixed is impregnated with 100~200L drinking water, soaking temperature is 20~30 DEG C, and soaking time is
20~45min；
When S3. impregnating, the container for impregnating medicinal material is put into ultrasound and is shaken；
It when S4. extracting, then toward addition 500~650L drinking water in medicinal material, is decocted, the time is 1.5~2h, is collected simultaneously and waves
Hair oil；
S5. then, medical fluid and the dregs of a decoction are separated, collects medical fluid；The drinking water of 350~500L is added into filter residue again, carries out pan-fried
It boils, the time is 2~3h, is collected simultaneously volatile oil；
S6. above-mentioned filtrate and filter residue are separated, takes filtrate, abandon filter residue；And the medical fluid extracted twice is mixed；
S7. Three-effect energy-saving inspissator, 80 DEG C of a temperature of effect, two effect 70 DEG C, triple effects 60 will be used after 200 mesh screens of gained medical fluid
DEG C being concentrated into relative density is 1.12 ± 0.05, obtains medicinal extract；
S8. 2/3 part of clear cream spray drying tower therein is taken, 160~180 DEG C of inlet air temperature, 80~100 DEG C of leaving air temp spraying
Extract powder is obtained at powder；
S9. remaining takes 1/3 part of clear cream to make adhesive, using extract powder as parent nucleus, is pelletized with one-step-granulating method, and inlet air temperature 60~
80 DEG C, 40~70 DEG C of leaving air temp, obtain particle；
S10. the volatile oil being collected into is added, stews to moisten overnight, is filled into 0.5g/ with capsule filling machine；It is distributed into obtain finished product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114868782A (en) * | 2022-06-06 | 2022-08-09 | 江西纤仁本草堂生物科技有限公司 | Ganxi food ten-flavor based composition and preparation method of medicine and food homologous food |
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2019
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114868782A (en) * | 2022-06-06 | 2022-08-09 | 江西纤仁本草堂生物科技有限公司 | Ganxi food ten-flavor based composition and preparation method of medicine and food homologous food |
| CN114868782B (en) * | 2022-06-06 | 2023-09-08 | 江西纤仁本草堂生物科技有限公司 | Ganshen ten-ingredient-based composition and preparation method of medicinal and edible food |
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