CN109803657A - 药物组合物 - Google Patents
药物组合物 Download PDFInfo
- Publication number
- CN109803657A CN109803657A CN201780062294.2A CN201780062294A CN109803657A CN 109803657 A CN109803657 A CN 109803657A CN 201780062294 A CN201780062294 A CN 201780062294A CN 109803657 A CN109803657 A CN 109803657A
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- CN
- China
- Prior art keywords
- methyl
- amino
- formula
- salt
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 32
- 150000001875 compounds Chemical class 0.000 claims abstract description 103
- 150000003839 salts Chemical class 0.000 claims abstract description 64
- 150000002148 esters Chemical class 0.000 claims abstract description 32
- 239000002792 enkephalinase inhibitor Substances 0.000 claims abstract description 16
- -1 arlysulfonylamino Chemical group 0.000 claims description 76
- 239000003814 drug Substances 0.000 claims description 31
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 30
- 229940079593 drug Drugs 0.000 claims description 24
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 24
- 239000013078 crystal Substances 0.000 claims description 23
- 239000011734 sodium Substances 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 21
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 19
- 125000003118 aryl group Chemical group 0.000 claims description 18
- 125000001072 heteroaryl group Chemical group 0.000 claims description 17
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 235000010290 biphenyl Nutrition 0.000 claims description 15
- 206010020772 Hypertension Diseases 0.000 claims description 14
- 229910052799 carbon Inorganic materials 0.000 claims description 14
- 229910052700 potassium Inorganic materials 0.000 claims description 13
- 150000001721 carbon Chemical group 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 10
- 206010019280 Heart failures Diseases 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000011591 potassium Substances 0.000 claims description 9
- 229910052708 sodium Inorganic materials 0.000 claims description 9
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 8
- 125000004494 ethyl ester group Chemical group 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
- 229910002651 NO3 Inorganic materials 0.000 claims description 7
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 7
- 229910052736 halogen Inorganic materials 0.000 claims description 7
- 150000002367 halogens Chemical class 0.000 claims description 7
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 238000006467 substitution reaction Methods 0.000 claims description 6
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 5
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 claims description 5
- 206010012601 diabetes mellitus Diseases 0.000 claims description 5
- 150000004702 methyl esters Chemical class 0.000 claims description 5
- SIJBDWPVNAYVGY-UHFFFAOYSA-N 2,2-dimethyl-1,3-dioxolane Chemical class CC1(C)OCCO1 SIJBDWPVNAYVGY-UHFFFAOYSA-N 0.000 claims description 4
- 201000001320 Atherosclerosis Diseases 0.000 claims description 4
- 239000004471 Glycine Substances 0.000 claims description 4
- 229910003202 NH4 Inorganic materials 0.000 claims description 4
- 229940000635 beta-alanine Drugs 0.000 claims description 4
- 208000010125 myocardial infarction Diseases 0.000 claims description 4
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims description 4
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- 206010002383 Angina Pectoris Diseases 0.000 claims description 3
- 206010003658 Atrial Fibrillation Diseases 0.000 claims description 3
- 206010003662 Atrial flutter Diseases 0.000 claims description 3
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- 206010024119 Left ventricular failure Diseases 0.000 claims description 3
- 206010042600 Supraventricular arrhythmias Diseases 0.000 claims description 3
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- 230000009787 cardiac fibrosis Effects 0.000 claims description 3
- 208000029078 coronary artery disease Diseases 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 206010020871 hypertrophic cardiomyopathy Diseases 0.000 claims description 3
- KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Chemical compound C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 claims description 2
- TZESSPPAPLHFEQ-UHFFFAOYSA-N 2-[(2-benzyl-3-sulfanylpropanoyl)amino]-1,3-thiazole-4-carboxylic acid Chemical compound OC(=O)C1=CSC(NC(=O)C(CS)CC=2C=CC=CC=2)=N1 TZESSPPAPLHFEQ-UHFFFAOYSA-N 0.000 claims description 2
- SUKNXYMRQLQQMI-UHFFFAOYSA-N 3-[(2-benzyl-3-sulfanylpropanoyl)amino]benzoic acid Chemical compound OC(=O)C1=CC=CC(NC(=O)C(CS)CC=2C=CC=CC=2)=C1 SUKNXYMRQLQQMI-UHFFFAOYSA-N 0.000 claims description 2
- ZCTDTVUDURCGFX-UHFFFAOYSA-N 3-[(2-benzyl-3-sulfanylpropanoyl)amino]propanoic acid Chemical compound OC(=O)CCNC(=O)C(CS)CC1=CC=CC=C1 ZCTDTVUDURCGFX-UHFFFAOYSA-N 0.000 claims description 2
- UXTJLCWDHLUAQF-UHFFFAOYSA-N 3-[[2-(acetylsulfanylmethyl)-3-phenylpropanoyl]amino]benzoic acid Chemical compound C=1C=CC(C(O)=O)=CC=1NC(=O)C(CSC(=O)C)CC1=CC=CC=C1 UXTJLCWDHLUAQF-UHFFFAOYSA-N 0.000 claims description 2
- NCSNXXXLRVRXIM-UHFFFAOYSA-N 4-[(2-benzyl-3-sulfanylpropanoyl)amino]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1NC(=O)C(CS)CC1=CC=CC=C1 NCSNXXXLRVRXIM-UHFFFAOYSA-N 0.000 claims description 2
- KJVKOEVEFLXJES-UHFFFAOYSA-N 7-[(2-benzyl-3-sulfanylpropanoyl)amino]heptanoic acid Chemical compound OC(=O)CCCCCCNC(=O)C(CS)CC1=CC=CC=C1 KJVKOEVEFLXJES-UHFFFAOYSA-N 0.000 claims description 2
- ZOQOKFIBJSQYEJ-NSHDSACASA-N C(C)(=O)SCC1(C=CC=C1)C(=O)N[C@@H](CCSC)C(=O)O Chemical compound C(C)(=O)SCC1(C=CC=C1)C(=O)N[C@@H](CCSC)C(=O)O ZOQOKFIBJSQYEJ-NSHDSACASA-N 0.000 claims description 2
- MPVBSAAMTKUPGT-ZDUSSCGKSA-N C(C)OC([C@@H](NC(=O)C1(C=CC=C1)CSC(C)=O)CCSC)=O Chemical compound C(C)OC([C@@H](NC(=O)C1(C=CC=C1)CSC(C)=O)CCSC)=O MPVBSAAMTKUPGT-ZDUSSCGKSA-N 0.000 claims description 2
- 125000004650 C1-C8 alkynyl group Chemical group 0.000 claims description 2
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 2
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims description 2
- 208000002330 Congenital Heart Defects Diseases 0.000 claims description 2
- 206010052337 Diastolic dysfunction Diseases 0.000 claims description 2
- 206010048554 Endothelial dysfunction Diseases 0.000 claims description 2
- 208000004248 Familial Primary Pulmonary Hypertension Diseases 0.000 claims description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 2
- BVMWIXWOIGJRGE-UHFFFAOYSA-N NP(O)=O Chemical compound NP(O)=O BVMWIXWOIGJRGE-UHFFFAOYSA-N 0.000 claims description 2
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims description 2
- 201000003099 Renovascular Hypertension Diseases 0.000 claims description 2
- 102000004377 Thiopurine S-methyltransferases Human genes 0.000 claims description 2
- 108090000958 Thiopurine S-methyltransferases Proteins 0.000 claims description 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 2
- 208000028831 congenital heart disease Diseases 0.000 claims description 2
- 230000008694 endothelial dysfunction Effects 0.000 claims description 2
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims description 2
- 125000005419 heteroarylsulfonylamino group Chemical group 0.000 claims description 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 2
- 229930182817 methionine Natural products 0.000 claims description 2
- YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical compound CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims description 2
- 201000008312 primary pulmonary hypertension Diseases 0.000 claims description 2
- 150000003214 pyranose derivatives Chemical class 0.000 claims description 2
- 208000004124 rheumatic heart disease Diseases 0.000 claims description 2
- 208000037812 secondary pulmonary hypertension Diseases 0.000 claims description 2
- 125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 claims description 2
- 125000003831 tetrazolyl group Chemical group 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- HNNQYHFROJDYHQ-UHFFFAOYSA-N 3-(4-ethylcyclohexyl)propanoic acid 3-(3-ethylcyclopentyl)propanoic acid Chemical compound CCC1CCC(CCC(O)=O)C1.CCC1CCC(CCC(O)=O)CC1 HNNQYHFROJDYHQ-UHFFFAOYSA-N 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
- 230000007721 medicinal effect Effects 0.000 abstract 1
- 239000002585 base Substances 0.000 description 38
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 31
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- 239000003112 inhibitor Substances 0.000 description 20
- 230000000694 effects Effects 0.000 description 17
- KGSXMPPBFPAXLY-UHFFFAOYSA-N azilsartan Chemical compound CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NOC(=O)N1 KGSXMPPBFPAXLY-UHFFFAOYSA-N 0.000 description 15
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 10
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 7
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 7
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 7
- 125000000623 heterocyclic group Chemical group 0.000 description 7
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- 229960004793 sucrose Drugs 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 229940071103 sulfosalicylate Drugs 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical class CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229950004288 tosilate Drugs 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-M undecanoate Chemical compound CCCCCCCCCCC([O-])=O ZDPHROOEEOARMN-UHFFFAOYSA-M 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000011706 wistar kyoto rat Methods 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
涉及一种药物组合物，包含：(a)至少一种中性内肽酶抑制剂或其药学上可接受的盐或酯、(b)至少一种如式(I)所示化合物或其药学上可接受的盐或酯、以及可药用载体。联合给药比单独给药具有更佳的药用效果：
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610887841.8 | 2016-10-08 | ||
| CN201610887841 | 2016-10-08 | ||
| PCT/CN2017/103651 WO2018064945A1 (zh) | 2016-10-08 | 2017-09-27 | 药物组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109803657A true CN109803657A (zh) | 2019-05-24 |
| CN109803657B CN109803657B (zh) | 2022-07-29 |
Family
ID=61831617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780062294.2A Active CN109803657B (zh) | 2016-10-08 | 2017-09-27 | 药物组合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11096928B2 (zh) |
| EP (1) | EP3524250A4 (zh) |
| CN (1) | CN109803657B (zh) |
| WO (1) | WO2018064945A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110237071A (zh) * | 2018-03-09 | 2019-09-17 | 武汉朗来科技发展有限公司 | 药物制剂及其应用 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108794342B (zh) * | 2017-04-28 | 2023-04-14 | 武汉朗来科技发展有限公司 | 羧酸铵盐化合物、其晶型、无定形物及其制备方法 |
| CN109748912B (zh) * | 2017-11-03 | 2023-08-22 | 武汉朗来科技发展有限公司 | 低杂质含量苯并咪唑衍生物的制备方法 |
| CN110237072B (zh) * | 2018-03-09 | 2022-03-25 | 武汉朗来科技发展有限公司 | 药物组合物的制备方法 |
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| WO2007045663A2 (en) * | 2005-10-19 | 2007-04-26 | Novartis Ag | Combination of an ati receptor antagonist and a np inhibitor fro treating ia hypertension and heartfailure |
| CN103709154A (zh) * | 2012-09-28 | 2014-04-09 | 武汉启瑞药业有限公司 | 苯并咪唑衍生物及其制备方法和医药用途 |
| CN104774196A (zh) * | 2014-01-09 | 2015-07-15 | 武汉朗来科技发展有限公司 | 一种苯并咪唑衍生物的制备方法 |
| CN105503760A (zh) * | 2014-10-10 | 2016-04-20 | 上海翰森生物医药科技有限公司 | 结晶型ARB-NEPi双阳离子复合物及其制备方法和应用 |
| CN105693543A (zh) * | 2014-12-15 | 2016-06-22 | 四川海思科制药有限公司 | 沙库比曲类衍生物、其药物组合物、制备方法及用途 |
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| WO1992013564A1 (en) * | 1991-02-06 | 1992-08-20 | Schering Corporation | Combination of an angiotensin ii antagonist or renin inhibitor with a neutral endopeptidase inhibitor |
| BRPI0306907B8 (pt) | 2002-01-17 | 2021-05-25 | Novartis Ag | composição farmacêutica, que compreende valsartan e inibidor de nep ou seus sais |
| US7157584B2 (en) | 2004-02-25 | 2007-01-02 | Takeda Pharmaceutical Company Limited | Benzimidazole derivative and use thereof |
| US20050288272A1 (en) * | 2004-06-23 | 2005-12-29 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and AT1 receptor antagonists |
| KR20080066776A (ko) * | 2005-11-08 | 2008-07-16 | 노파르티스 아게 | 안지오텐신 ⅱ 수용체 봉쇄제, 칼슘 채널 봉쇄제 및 다른활성 약제의 조합물 |
| CN105837464A (zh) | 2015-01-15 | 2016-08-10 | 四川海思科制药有限公司 | 沙库比曲钠的晶型及其制备方法和用途 |
| CN107602546B (zh) * | 2016-07-11 | 2022-04-22 | 武汉朗来科技发展有限公司 | 化合物的晶型及其制备方法、组合物和应用 |
-
2017
- 2017-09-27 WO PCT/CN2017/103651 patent/WO2018064945A1/zh unknown
- 2017-09-27 US US16/340,035 patent/US11096928B2/en active Active
- 2017-09-27 CN CN201780062294.2A patent/CN109803657B/zh active Active
- 2017-09-27 EP EP17857826.6A patent/EP3524250A4/en active Pending
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| WO2007045663A2 (en) * | 2005-10-19 | 2007-04-26 | Novartis Ag | Combination of an ati receptor antagonist and a np inhibitor fro treating ia hypertension and heartfailure |
| CN103709154A (zh) * | 2012-09-28 | 2014-04-09 | 武汉启瑞药业有限公司 | 苯并咪唑衍生物及其制备方法和医药用途 |
| CN104774196A (zh) * | 2014-01-09 | 2015-07-15 | 武汉朗来科技发展有限公司 | 一种苯并咪唑衍生物的制备方法 |
| CN105503760A (zh) * | 2014-10-10 | 2016-04-20 | 上海翰森生物医药科技有限公司 | 结晶型ARB-NEPi双阳离子复合物及其制备方法和应用 |
| CN105693543A (zh) * | 2014-12-15 | 2016-06-22 | 四川海思科制药有限公司 | 沙库比曲类衍生物、其药物组合物、制备方法及用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110237071A (zh) * | 2018-03-09 | 2019-09-17 | 武汉朗来科技发展有限公司 | 药物制剂及其应用 |
| CN110237071B (zh) * | 2018-03-09 | 2022-03-22 | 武汉朗来科技发展有限公司 | 药物制剂及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20200038379A1 (en) | 2020-02-06 |
| CN109803657B (zh) | 2022-07-29 |
| US11096928B2 (en) | 2021-08-24 |
| WO2018064945A1 (zh) | 2018-04-12 |
| EP3524250A4 (en) | 2020-05-20 |
| EP3524250A1 (en) | 2019-08-14 |
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