CN109771497A - A kind of blood pressure decreasing capsule and preparation method - Google Patents
A kind of blood pressure decreasing capsule and preparation method Download PDFInfo
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- CN109771497A CN109771497A CN201910222461.6A CN201910222461A CN109771497A CN 109771497 A CN109771497 A CN 109771497A CN 201910222461 A CN201910222461 A CN 201910222461A CN 109771497 A CN109771497 A CN 109771497A
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Abstract
The invention belongs to technical field of traditional Chinese medicines, a kind of blood pressure decreasing capsule and preparation method are disclosed, is made of uncaria 250g, Radix Paeoniae Alba 200g, nifedipine 10.0g, atenolol 12.5g and Hydrochioro 6.25g.Choose good uncaria, Radix Paeoniae Alba, nifedipine, atenolol and Hydrochioro；Hook taking rattan, two taste Chinese medicine of Radix Paeoniae Alba, are ground into fine powder；Nifedipine, atenolol and three taste of Hydrochioro are ground into fine powder；Sterilizing, uncaria fine powder, Radix Paeoniae Alba fine powder are set into thermostatic drying chamber, fine powder thickness control 2cm in square plate, sterilising temp controls 105 DEG C, 12 hours, thermostatic drying chamber is closed, is mixed when temperature is down to room temperature, then with fine powder 2, obtain mixing fine powders, the fine powder of uncaria fine powder, Radix Paeoniae Alba fine powder and nifedipine, atenolol and Hydrochioro is mixed, mixing fine powders are obtained, it is spare；Mixing fine powders are fitted into Capsules, are made 1000, are bottled to get blood pressure decreasing capsule.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines more particularly to a kind of blood pressure decreasing capsule and preparation methods.
Background technique
Currently, the prior art commonly used in the trade is such that
Kallikreins-kinins System is a complicated endogenous multienzyme system, mainly by kininogen, kallikrein
It forms, is widely present in blood and many organs and tissue with kassinin kinin, by participating in regulation blood pressure, body fluid in conjunction with its receptor
It is sick with the different physiological roles and inflammation, pain and cell Proliferation etc. such as electrolyte balance；With hypertension and its target organ damage
Occur that there is substantial connection with development.Herbal mixture have regulating blood pressure and target organ protection function, partial action mechanism with
Kallikreins-kinins System balance adjustment is related.
KKS is one of internal main depressurizing system, is an important composition portion for maintaining depressurizing system in blood pressure balance
Point.Depressurizing system functional defect or inhibition take part in the occurrence and development of hypertension and its target organ damage, and deposit between KKS
It connects each other and interacts in complicated.Existing many antihypertensive drugs can play decompression and target directly or indirectly through KKS
Organ protection.Traditional Chinese medicine is improving high blood pressure symptom, is stablizing curative effect, prevention and treatment using organic conception, diagnosis and treatment as foundation
Target organ damage etc. has its unique advantage, and has carried out a large amount of clinical observation and animal experiment study.Due to Chinese medicine
The especially complexity of compound Chinese herbal medicinal ingredients, Mechanism Study still in its infancy, and has focused largely on RAS, for KKS's
It inquires into relatively fewer.Therefore, Chinese medicine is carried out in a deep going way to the Effect study of hypertension KKS, and illustrates Chinese medicine multipath, polycyclic
The pharmacological property of section, multiple target point and bidirectional modulation is of great significance.
In conclusion problem of the existing technology is:
(1) in recent years, greater advance is achieved using the clinic and experimental study of traditional Chinese medicine treatment essential hypertension,
Chinese medicine for lowering high blood pressure can be obviously improved the clinical symptoms of patient, improve the quality of living, and the also unique advantage in terms of target-organ protection.
But there are still many problems, such as Chinese medicine for lowering high blood pressure study on mechanism to need to be goed deep at present, it should be from multi-angle, stage construction to list
Taste Chinese medicine, herbal mixture carry out system, multi-level, manifold effect series of studies, with modern advanced science and technology, from body
Sign, organ, cell even Molecular level study Chinese medicine for lowering high blood pressure effect and mechanism, screen more effective Chinese medicine compound prescription and its effectively at
Point.
(2) liver-Yang sthenia type essential hypertension is the most common cardiovascular disease, can notably cause the serious heart, brain,
Kidney complication, is cerebral apoplexy, the Major Risk Factors of coronary heart disease, therefore need to be prevented and treated as early as possible, in order to avoid the generation of complication.West
Medical circles not yet find its pathogenic basic reason, use a few hypotensor symptomatic treatments at present.Chinese medicine thinks that this disease belongs to liver-yang
Rising type dizziness, this type of patient is mostly due to innate excess of YANG in the body, liver-yang hyperactivity；Or because long-term melancholy angry, the obstruction of the circulation of vital energy is under fire, and keeps liver-yin dark
Consumption, wind sun rise dynamic, pathogen upward attacking orifices in head or chronic deficiency of kidney-YIN the liver failing to be nourished cause deficiecny of liver-YIN, liver-yang hyperactivity.Card is shown in dizziness and tinnitus, head disease
And it is swollen, flushing irritability is just done, red tongue with yellowish fur, wiry and frequent pulse.It controls and should give calming the liver to stop the wind, heat clearing and tranquillizing is method.And Western medicine is often
Palliative, only simple antihypertensive effect.
(3) hypertension is most commonly seen chronic cardiovascular disease, is the significant risk of the cardiovascular and cerebrovascular diseases such as coronary heart disease
Factor.In recent years, more and more researches show that, old ISH patients' blood fluctuating range is big, Yi Yinqi postural hypotension,
Heart failure etc., risk with higher.Therefore, reinforce the prevention and treatment to treatment of older patient with isolated systolic, there is important meaning
Justice.Hypertension is disease of multifactorial inheritance, while being influenced by factors such as life styles, and blood pressure decreasing capsule is a kind of effective
Clinical treatment, the key that senile patients with isolated systolic hypertension is cured.
Solve the difficulty and meaning of above-mentioned technical problem: essential hypertension obviously increases the targets device such as the heart, brain, kidney, blood vessel
The damage of official needs long-term administration to maintain the normal of blood pressure.Though Chinese medicine for lowering high blood pressure is fast not as good as Western medicine speed, antihypertensive effect is strong,
Its effect is multiple target point, while decompression, also takes into account other pathology links of hypertension, and having improves microcirculation, lipid-loweringing
The multiple actions such as anti-oxidant, protection blood vessel endothelium, adjusting vaso-active substance.Mitigate the adverse reaction for taking Western medicine simultaneously, changes
Kind symptom.Chinese traditional treatment essential hypertension is gradually valued by people.In recent years, the high blood of primary is treated using traditional Chinese medicine
The clinic and experimental study of pressure achieve greater advance, and Chinese medicine for lowering high blood pressure can be obviously improved the clinical symptoms of patient, improve life
Quality, and the also unique advantage in terms of target-organ protection.But there are still many problems, such as Chinese medicine for lowering high blood pressure to act on machine at present
System research needs to be goed deep into, and should carry out system, multi-level, manifold effect system to single medicinal material, herbal mixture from multi-angle, stage construction
Column research, with modern advanced science and technology, from the even Molecular level study Chinese medicine for lowering high blood pressure effect of sign, organ, cell and
Mechanism filters out the Chinese and Western medicine compound preparation of blood pressure decreasing capsule；In the shortcoming for improving Chinese medicine treatment essential hypertension, also make
It obtains Western medicine and plays its due effect, Chinese medicine Western medicine, which combines, can preferably treat hypertension, blood pressure decreasing capsule collaborative treatment of Chinese and western medicines
The advantage of rapid, the reliable antihypertensive effect of Western medicine can be played, while dredging blood vessel, adjustment yin-yang, improvement heart and brain kidney can be passed through again
Blood flow supply-demand relationship, play Chinese medicine and fundamentally treat the advantage of disease, reduce the pathological factor for causing high blood pressure, improve and suffer from
Person's symptom improves its life quality.Injury will not be brought to body.Blood pressure decreasing capsule Chinese medicine Western medicine is incorporated in the prevention and treatment high blood of primary
Pressure aspect obtains bigger breakthrough.
Summary of the invention
In view of the problems of the existing technology, the present invention provides a kind of blood pressure decreasing capsule and preparation methods.
The invention is realized in this way a kind of blood pressure decreasing capsule, the blood pressure decreasing capsule is by uncaria 250g, Radix Paeoniae Alba 200g, nitre benzene
Horizon 10.0g, atenolol 12.5g and Hydrochioro 6.25g composition.
Another object of the present invention is to provide a kind of preparation method of blood pressure decreasing capsule, the preparations of the blood pressure decreasing capsule
Method includes:
The first step chooses good uncaria, Radix Paeoniae Alba, nifedipine, atenolol and Hydrochioro；
Uncaria, Radix Paeoniae Alba identify respectively after picking net, nifedipine, atenolol and Hydrochioro by second step
It is identified respectively；
Third step, hook taking rattan, two taste Chinese medicine of Radix Paeoniae Alba, it is spare to be ground into fine powder 1；Take nifedipine, atenolol and hydrogen chlorine
It is spare that three taste of thiazine is ground into fine powder 2；
Fine powder 1 is uniformly mixed by the 4th step by second step, sets thermostatic drying chamber, fine powder thickness control 2cm in square plate,
Sterilising temp controls 105 DEG C and sterilizes for 12 hours, closes thermostatic drying chamber, is mixed when temperature is down to room temperature, then with fine powder 2
It is even, mixing fine powders are obtained, it is spare；
The fine powder of 5th step, uncaria fine powder, Radix Paeoniae Alba fine powder and nifedipine, atenolol and Hydrochioro is mixed,
Mixing fine powders are obtained, it is spare；The sampling of above-mentioned fine powder is tested, it is spare after qualified；
Above-mentioned fine powder is packed into Capsules, adjusts fully-automatic capsule filling machine, make every dress 0.45g, in glue by the 6th step
Every 0.5 hour in the preparation process of capsule, it is necessary to a loading amount selective examination is carried out, quality is controlled, is made 1000, bottle, system
Obtain blood pressure decreasing capsule.
Further, the second step specifically includes:
(1) identifying respectively after pick net for uncaria, Radix Paeoniae Alba, be put into thermostatic drying chamber, temperature control is 95 DEG C, 1
Hour, coarse crushing after mixing, operation pulverizer carries out coarse crushing and crosses 20 meshes, and mixing coarse powder is made, and 95 DEG C of -100 DEG C of constant temperature are dry
Dry case is 2 hours dry, then is ground into fine powder, crosses 120 mesh；
It is spare；
(2) nifedipine, atenolol and Hydrochioro are identified respectively, weigh nifedipine 10.0g, Ah after qualified
It is ground into fine powder for Luo Er 12.5g and tri- taste of Hydrochioro 6.25g, it is spare；
(3) it sterilizes: by above-mentioned uncaria, Radix Paeoniae Alba fine powder, setting thermostatic drying chamber, fine powder thickness control 2cm in square plate, sterilizing temperature
105 DEG C of degree control sterilize for 12 hours, close thermostatic drying chamber, are mixed when temperature is down to room temperature, then with fine powder 2, spare.
In conclusion advantages of the present invention and good effect are as follows:
The clinical data for 100 primary hypertension patients accepted for medical treatment during the 1-12 month in 2014 carries out retrospective analysis,
Control group and observation group are classified as using parallel method of random sampling, each 50.Male 28 in control group, women 22；Year
Age 51~78 years old, average (63.34 ± 6.42) year；The course of disease 4~27 years, average (10.72 ± 6.42) year.Male 27 in observation group
Example, women 23；Age 53~79 years old, average (61.04 ± 9.71) year；The course of disease 4~25 years, average (9.33 ± 1.86) year.
All patients through coherence check meet the World Health Organization (WHO) formulation the diagnostic criteria about hypertension, exclude with
Hepatic renal dysfunction, phrenoblabia and malignant tumor patient.Two groups of patients no significant difference in terms of gender, age, the course of disease,
It is comparable.
1 two groups of clinical therapeutic efficacy comparisons [n (%)] of table
Table 2 treat during two groups of adverse reactions a situation arises comparison [n (%)]
100 patients are equally divided into control group and each 50 of observation group, control group give nifedipine, atenolol and
Hydrochioro, observation group apply blood pressure decreasing capsule, as a result, it has been found that the blood pressure level of observation group restores normal after treatment, antihypertensive effect is bright
It is aobvious to be better than control group；And play its reduction blood lipid while effectively control blood pressure, slow down the effect of heart rate, to reduce the heart
The onset risk of angiosis reduces clinical case fatality rate.In the research of this group, observation group's total effective rate is 90%, and control group is always effective
Rate is 76%, and observation group is apparently higher than control group, and difference has statistical significance, and during treating observation group adverse reaction
Incidence is 10%, and the adverse reaction rate of control group is 16%, and control group is slightly above control group, but difference does not have statistics
Learn meaning.For clinical observation result in terms of decompression, Radix Paeoniae Alba uncaria is shared with nifedipine, atenolol and Hydrochioro can be excellent
Gesture is complementary, brings out the best in each other, effect is more significant, and nifedipine, atenolol and Hydrochioro is applied alone in ratio in terms of symptom improvement
Effect becomes apparent；And illustrate to be depressured glue then than only using nifedipine, atenolol and Hydrochioro few in terms of adverse reaction
Capsule can play the role of synergy Reduction of Students' Study Load, to achieve the purpose that decompression is at a specified future date；Primary hypertension patient can obviously be controlled
Blood pressure level, it is curative for effect, it can be used as preferred therapeutic regimen and promoted in clinic.
Detailed description of the invention
Fig. 1 is the preparation method flow chart of blood pressure decreasing capsule provided in an embodiment of the present invention.
Fig. 2 is the preparation method implementation flow chart of blood pressure decreasing capsule provided in an embodiment of the present invention.
Fig. 3 is the preparation method principle flow chart of blood pressure decreasing capsule provided in an embodiment of the present invention.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
A kind of blood pressure decreasing capsule provided by the invention and preparation method, the blood pressure decreasing capsule is by quality by uncaria 250g, Radix Paeoniae Alba
200g, nifedipine 10.0g, atenolol 12.5g and Hydrochioro 6.25g composition.
The present invention will be described in further detail with reference to the accompanying drawing；
As shown in Figure 1, the preparation method of blood pressure decreasing capsule provided in an embodiment of the present invention includes:
S101: good uncaria, Radix Paeoniae Alba, nifedipine, atenolol and Hydrochioro are chosen；
S102: uncaria, Radix Paeoniae Alba identify respectively after picking net, nifedipine, atenolol and Hydrochioro point
It is not identified；
S103: it is spare to be ground into fine powder 1 for hook taking rattan, two taste Chinese medicine of Radix Paeoniae Alba；Take nifedipine, atenolol and esodrix
It is spare that three taste of piperazine is ground into fine powder 2；
S104: by step S102, fine powder 1 being uniformly mixed, and sets thermostatic drying chamber, fine powder thickness control 2cm in square plate,
Sterilising temp controls 105 DEG C and sterilizes for 12 hours, closes thermostatic drying chamber, is mixed when temperature is down to room temperature, then with fine powder 2
It is even, mixing fine powders are obtained, it is spare；
S105: the fine powder of uncaria fine powder, Radix Paeoniae Alba fine powder and nifedipine, atenolol and Hydrochioro is mixed, and is obtained
Mixing fine powders, it is spare；The sampling of above-mentioned fine powder is tested, it is spare after qualified；
S106: above-mentioned fine powder is packed into Capsules, fully-automatic capsule filling machine is adjusted, makes every dress 0.45g, in capsule
Preparation process in every 0.5 hour, it is necessary to carry out the selective examination of loading amount, be controlled quality, be made 1000, bottle, be made
Blood pressure decreasing capsule.
Step S102 is specifically included: (1) uncaria, Radix Paeoniae Alba pick net after respectively identify, is put into thermostatic drying chamber,
Temperature control is 95 DEG C, and 1 hour, coarse crushing after mixing, operation pulverizer carried out coarse crushing and crosses 20 meshes, and mixing coarse powder is made,
95 DEG C of -100 DEG C of thermostatic drying chambers are 2 hours dry, then are ground into fine powder, cross 120 mesh；
It is spare；
(2) nifedipine, atenolol and Hydrochioro are identified respectively, weigh nifedipine 10.0g, Ah after qualified
It is ground into fine powder for Luo Er 12.5g and tri- taste of Hydrochioro 6.25g, it is spare；
(3) it sterilizes: by above-mentioned uncaria, Radix Paeoniae Alba fine powder, setting thermostatic drying chamber, fine powder thickness control 2cm in square plate, sterilizing temperature
105 DEG C of degree control sterilize for 12 hours, close thermostatic drying chamber, are mixed when temperature is down to room temperature, then with fine powder 2, spare.
Below with reference to the drug effects of various bulk pharmaceutical chemicals, the present invention will be described in further detail；
Radix Paeoniae Alba returns liver, spleen, lung three to pass through, calming the liver and relieving pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating；For headache and dizziness, hypochondriac pain, abdomen
Bitterly, four limbs contraction pain, blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat.
Uncaria, sweetness and bitterness；It is slightly cold；The flat liver of heat-clearing；Relieving convulsion and spasm；The major functions: child convulsion；The morbid night crying of babies；Excess heat moves wind；Eclampsia；Liver
Positive dizziness；Irascibility distending pain in the head；Uncaria has antihypertensive effect simultaneously, has very high medical value.
Uncaria compatibility Radix Paeoniae Alba: uncaria calming the liver cool in nature sweet in flavor, clearing heat for calming endogenous wind control the mark of liver-yang hyperactivity partially；The sour soft liver cold in nature of Radix Paeoniae Alba is supported
This Papillary giving consideration to both the incidental and fundamental that the function that yin, calming the liver have a nourishing the liver body and hold back irritability, Pinggan Yang enables irritability not recklessly act is apt to tonifying liver void is total to
It is more that the effect of playing soft liver yin-nourishing, suppressing hyperactive liver for calming endogenous wind is used to treat deficiecny of liver-YIN, the headache and dizziness of empty positive rising, being irritable and getting angry easily, insomnia
The diseases such as dream.
Nifedipine, for preventing and treating coronary disease and angina pectoris, especially variant angina pectoris and coronarospasm
Caused angina pectoris；There is no adverse effect to respiratory function, therefore be suitable for the patient with angina pectoris with respiratory obstructive disease,
Curative effect is better than beta receptor antagonist；Various types of hypertension are applied also for, also have good therapeutic effect to intractable, severe hypertension.
Atenolol, it is a kind of suitable for caused by a variety of causes that white to pale white crystals powder is odorless or micro- smelly
In, mild hypertension disease, 1 adrenoreceptor blocker of selective β including aged hypertensives and gestation hypertension.
Hydrochioro, white crystalline powder is odorless, mildly bitter flavor；It is diuretics, antihypertensive；It is primarily adapted for use in heart original
Property oedema, hepatic edema and renal edema: such as nephrotic syndrome, acute glomerulonephritis, chronic renal failure and kidney
Oedema caused by upper gland cortin and hyperestrogenism；Hypertension；Diabetes insipidus.
Fig. 2 is the preparation method process flow chart of blood pressure decreasing capsule provided in an embodiment of the present invention.
The present invention will be described in further detail combined with specific embodiments below；
Embodiment 1. identifies
(1) this product content 2.5g is taken, water-saturated n-butanol 15ml is added, is ultrasonically treated 15 minutes, filtration, filtrate is evaporated,
Residue adds ethyl alcohol 2ml to make to dissolve, as test solution.It separately takes Paeoniflorin reference substance appropriate, adds ethyl alcohol that every 1ml is made containing 1mg
Solution, as reference substance solution.It tests, draws above-mentioned according to thin-layered chromatography (one VI B of annex of Chinese Pharmacopoeia version in 2015)
Each 10 μ l of two kinds of solution, puts respectively on same silica gel g thin-layer plate, with dichloromethane-ethyl acetate-methyl alcohol-formic acid (40:
5: 10: 0.2) being solvent, be unfolded, take out, dry, spray with 5% vanillin-sulfuric acid solution, it is clear to be heated to spot development.
In sample chromatogram, at the position corresponding to the chromatogram of the reference substance, the spot of same color is shown.
(2) this product content 1.5g is taken, methanol 5ml is added, is ultrasonically treated 10 minutes, stands, takes supernatant as test sample
Solution.It separately takes nifedipine reference substance appropriate, adds methanol that solution of every 1ml containing 5mg is made, as reference substance solution.According to thin layer
Chromatography (one VI B of annex of Chinese Pharmacopoeia version in 2015) test, draws each 3 μ l of above two solution, is put respectively in same silicon
Glue GF254On lamellae, with toluene-ethyl acetate-diethylamine (12: 6: 0.5) for solvent, it is unfolded, takes out, dry, set purple
It is inspected under outer smooth lamp (254nm).
In sample chromatogram, at the position corresponding to the chromatogram of the reference substance, the spot of same color is shown.
(3) test solution under (identification) (2) item is taken, as test solution.It separately takes Hydrochioro reference substance appropriate, adds
Solution of every 1ml containing 2mg is made in methanol, as reference substance solution.According to thin-layered chromatography (Chinese Pharmacopoeia one annex of version in 2015
VI B) test, each 2 μ l of above two solution is drawn, is put respectively in same silica G F254On lamellae, with chloroform-methanol
(20: 5) it is solvent, is unfolded, takes out, dry, set and inspected under ultraviolet lamp (254nm).
In sample chromatogram, at the position corresponding to the chromatogram of the reference substance, the spot of same color is shown.
The character of blood pressure decreasing capsule provided by the invention: this product is hard capsule, and content is the faint yellow powder to brown color；
Bitter.
The inspection of blood pressure decreasing capsule provided by the invention: related every regulation (Chinese Pharmacopoeia under Ying Fuhe capsule item
One I L of annex of version in 2015).
The indication of blood pressure decreasing capsule provided by the invention: calming the liver, calming heart decompression；All types of height for liver-yang hyperactivity
Blood pressure.
The usage and dosage of blood pressure decreasing capsule provided by the invention: it is oral, once a grain, 2 times a day.
The specification of blood pressure decreasing capsule provided by the invention: every dress 0.45g.
The holding conditions of blood pressure decreasing capsule provided by the invention: it is closed, it sets at shady and cool drying.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (3)
1. a kind of blood pressure decreasing capsule, which is characterized in that the blood pressure decreasing capsule by uncaria 250g, Radix Paeoniae Alba 200g, nifedipine 10.0g,
Atenolol 12.5g and Hydrochioro 6.25g composition.
2. a kind of preparation method of blood pressure decreasing capsule as described in claim 1, which is characterized in that the preparation method of the blood pressure decreasing capsule
Include:
The first step chooses good uncaria, Radix Paeoniae Alba, nifedipine, atenolol and Hydrochioro；
Uncaria, Radix Paeoniae Alba identify respectively after picking net by second step, nifedipine, atenolol and Hydrochioro difference
It is identified；
Third step, hook taking rattan, two taste Chinese medicine of Radix Paeoniae Alba, it is spare to be ground into fine powder 1；Take nifedipine, atenolol and Hydrochioro
It is spare that three tastes are ground into fine powder 2；
Fine powder 1 is uniformly mixed by the 4th step by second step, sets thermostatic drying chamber, fine powder thickness control 2cm in square plate, sterilizing
Temperature controls 105 DEG C and sterilizes for 12 hours, closes thermostatic drying chamber, is mixed, obtained when temperature is down to room temperature, then with fine powder 2
Mixing fine powders, it is spare；
The fine powder of 5th step, uncaria fine powder, Radix Paeoniae Alba fine powder and nifedipine, atenolol and Hydrochioro is mixed, and is obtained mixed
Fine powder is closed, it is spare；The sampling of above-mentioned fine powder is tested, it is spare after qualified；
Above-mentioned fine powder is packed into Capsules, adjusts fully-automatic capsule filling machine, make every dress 0.45g, in capsule by the 6th step
Every 0.5 hour in preparation process, it is necessary to carry out a loading amount selective examination, be controlled quality, be made 1000, drop is made in bottling
Moulding capsule.
3. the preparation method of blood pressure decreasing capsule as claimed in claim 2, which is characterized in that the second step specifically includes:
(1) identifying respectively after pick net for uncaria, Radix Paeoniae Alba, be put into thermostatic drying chamber, temperature control is 95 DEG C, 1 hour,
Coarse crushing after mixing, operation pulverizer carry out coarse crushing and cross 20 meshes, and mixing coarse powder is made, and 95 DEG C of -100 DEG C of thermostatic drying chambers are dry
Dry 2 hours, then it is ground into fine powder, cross 120 mesh；It is spare；
(2) nifedipine, atenolol and Hydrochioro are identified respectively, weigh nifedipine 10.0g, Ah Ti Lip river after qualified
That 12.5g and tri- taste of Hydrochioro 6.25g are ground into fine powder, spare；
(3) it sterilizes: by above-mentioned uncaria, Radix Paeoniae Alba fine powder, setting thermostatic drying chamber, fine powder thickness control 2cm in square plate, sterilising temp control
105 DEG C of system sterilize for 12 hours, close thermostatic drying chamber, are mixed when temperature is down to room temperature, then with fine powder 2, spare.
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| CN110755505A (en) * | 2019-12-05 | 2020-02-07 | 福建省南平市人民医院（福建省南平市中医院） | Medicine for treating hypertension and preparation method thereof |
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| CN107308181A (en) * | 2017-07-18 | 2017-11-03 | 卢广荣 | Treat the compound medicinal formulation of refractory hypertension |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110231429A (en) * | 2019-06-05 | 2019-09-13 | 江南大学 | A kind of method of high performance thin layer chromatography combination biloluminescence method screening nifedipine |
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| CN110755505A (en) * | 2019-12-05 | 2020-02-07 | 福建省南平市人民医院（福建省南平市中医院） | Medicine for treating hypertension and preparation method thereof |
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Application publication date: 20190521 |