CN109771323A - A kind of anti-aging peptide composition and its application - Google Patents
A kind of anti-aging peptide composition and its application Download PDFInfo
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- CN109771323A CN109771323A CN201910240664.8A CN201910240664A CN109771323A CN 109771323 A CN109771323 A CN 109771323A CN 201910240664 A CN201910240664 A CN 201910240664A CN 109771323 A CN109771323 A CN 109771323A
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- aging
- peptide composition
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- aging peptide
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Abstract
The invention discloses a kind of anti-aging peptide composition and its applications.Anti-aging peptide composition provided by the invention includes Argireline, acetyl group tetrapeptide -5 and elastin hydrolysis.The anti-aging peptide composition rationally compounds each polypeptide functional component by the research of science, can be realized synergy, to reach optimal anti-ageing anti-wrinkle effect, and is used in compounding the senile-resistant efficacy for not influencing peptide composition with other active matters.The anti-aging peptide composition is for that can meet different use demands in cosmetics.Therefore, the effect of which is added in the cosmetics such as lotion, cream, toner or Essence as raw material, supplies nutrition for skin, has both anti-aging and moisturizing.
Description
Technical field
The present invention relates to the technical field of cosmetics, in particular to a kind of anti-aging peptide composition and its application.
Background technique
The main feature of skin aging is the increase of face wrinkles, this be both human gene pre-selection arrange program and
There are the factor of environment, for example facial skin is constantly by compressing (as during sleep), muscle caused by regular countenance
Contractile motion etc..From physiologically saying, the aging of skin shows the reduction of collagen and elastin laminin, skin oil and fat
Random arrangement.
Elastin laminin is the important element for forming skin corium, accounts for about 5% in vivo, but administers 95% skin elasticity,
It allows skin as rubber band, full of elasticity, and maintains young compact profile.Although with advancing age, skin is inevitable
Aging, change relaxation, the original state but as long as elastin laminin is supplemented, when skin can still reply 20 years old.Specialize in human body skin
The scientist Peter T.Pugliese of skin, M.D. are pointed out: " although the various albumen in body are all critically important, to the outer of people
For seeing and feeling, signal protein more not prior than elastin laminin ".
Elastomer exists jointly in skin with collagenous fibres, assigns tissue with elasticity and tensile energy, through pullling it
After can retract rapidly, therefore skin is allowed to be able to maintain elasticity.With age, elastin laminin just stops producing, the bullet in skin
Property albumen ingredient reduce, jointly reduce to network support required for compact skin is maintained, be as a result exactly skin pine occur
Relaxation, soft edge, skin have the aging phenomena such as microgroove.Scientific research confirms that the age of skin is determined by the percentage of elastin laminin
It is fixed, the only elastin laminin two-dimension elastic that is capable of providing and keeps skin.
Nowadays due to expanding economy, people's lives quality gradually improves, more and more allegro in work, life
Skin care is also increasingly paid attention to simultaneously.At present the category accounting of moisture-keeping efficacy is maximum in skin care item on the market, at present people
Mainstream skin care consciousness is also maintained at most basic moisturizing moisturizing, while moisturizing moisturizing is also to carry out earliest and compare in skin care item research
It is easier to the effect of realizing.Demand with people to skin-care effect is higher and higher, how to accomplish both to can guarantee product
Safety, while there are authentic and valid anti-aging effects again, exactly it is desirable that for consumer's solution.
Summary of the invention
The primary purpose of the present invention is that the shortcomings that overcoming the prior art and deficiency, provide a kind of anti-aging polypeptides in combination
Object.
Another object of the present invention is to provide the applications by above-mentioned anti-aging peptide composition.
A further object of the present invention is to provide a kind of cosmetics with senile-resistant efficacy.
The purpose of the invention is achieved by the following technical solution: a kind of anti-aging peptide composition, includes acetyl group hexapeptide-
8, acetyl group tetrapeptide -5 and elastin hydrolysis.
The mass ratio of each ingredient is preferably Argireline in the anti-aging peptide composition: acetyl group four
Peptide -5: elastin hydrolysis=1~50:1~50:1~40；More preferably 5~6:3~5:2~5.
The anti-aging peptide composition also includes at least one of bacteriostatic agent and water.
The bacteriostatic agent is that skin care item often use bacteriostatic agent；Preferably Phenoxyethanol, 1,2- pentanediol, pungent glycol, sorb
One of sour potassium or at least two；More preferably pungent glycol.
Content of the bacteriostatic agent in the anti-aging peptide composition meets the relevant regulations of country, industry；
Preferably mass percent 0.01~20%.
The dosage of the water is surplus.
A kind of anti-aging peptide composition freeze-dried powder contains above-mentioned anti-aging peptide composition and lyophilization aid.
The lyophilization aid is one or both of alcohols material and glucide.
The alcohols material is preferably mannitol.
The glucide is preferably lactose.
Content of the lyophilization aid in the freeze-dried powder is mass percent 0.1~99.9%；Preferably 5~
30%；More preferably 10~25%.
The preparation method of the freeze-dried powder the following steps are included: water and lyophilization aid are uniformly mixed, then with acetyl group
Hexapeptide -8, acetyl group tetrapeptide -5, elastin hydrolysis and bacteriostatic agent are uniformly mixed, and are carried out vacuum freeze drying, are obtained freeze-dried powder.
Above-mentioned anti-aging peptide composition is preparing the application in cosmetics.
Above-mentioned anti-aging peptide composition freeze-dried powder is preparing the application in cosmetics.
The cosmetics are the cosmetics of broad sense, the cosmetics including skin care item and narrow sense.
Content of the anti-aging peptide composition in the cosmetics is mass percent 0.001~60%；
Preferably mass percent 5~40%；More preferably mass percent 10~20%.
In a preferred embodiment in accordance with this invention, the content of anti-aging peptide composition described in cosmetics is
Mass percent 13%；Wherein the mass ratio of each ingredient is preferably Argireline: acetyl group tetrapeptide -5: hydrolyzed elastin egg
It is white: pungent glycol=5:3:4:1.
In a preferred embodiment in accordance with this invention, the content of anti-aging peptide composition described in cosmetics is
Mass percent 15%；Wherein the mass ratio of each ingredient is preferably Argireline: acetyl group tetrapeptide -5: hydrolyzed elastin egg
It is white: pungent glycol=6:5:2:2.
A kind of cosmetics with senile-resistant efficacy are made of acceptable carrier on active constituent and cosmetics；Activity
Ingredient is that above-mentioned anti-aging peptide composition or above-mentioned anti-aging peptide composition are combined with other function substance.
The other function substance includes moisturizing substance, anti-ageing substance, compact substance, whitening material and antiallergy
Substance.
The cosmetics with senile-resistant efficacy also may include polyalcohol, grease, emulsifier, pH adjusting agent, antioxygen
At least one of agent, preservative, pigment and essence ingredient and water.
The dosage of the water is surplus.
The antioxidant, preservative, pigment and essence dosage be it is appropriate, meet the relevant regulations such as country, industry.
A kind of anti-aging polypeptide Essence contains above-mentioned anti-aging peptide composition.
The anti-aging polypeptide Essence includes following component as mass fraction: the anti-aging polypeptides in combination
Object 10~18%, Phenoxyethanol 0.1~2%, EDETATE SODIUM 0.01~2%, methyl esters 0.01~1.5%, methyl propanediol 1~
8%, glycerol 1~10%, Sodium Hyaluronate 0.01~3%, water surplus.
A kind of anti-aging polypeptide lotion contains above-mentioned anti-aging peptide composition.
The anti-aging lotion includes following component as mass fraction: the anti-aging peptide composition 10~
20%, decoyl hydroximic acid 0.01~0.5%, 1,2- pentanediol 0.1~4%, surfactant 0.1%~3, the smooth stearic acid of sorb
Ester 0.01~0.6%, emulsifier 0.5~2.5%, polysorbate -60 0.5~2%, saualane 1~7%, phytosterol 1
~6%, Scleroglucan 0.5~4%, inositol 0.5~3.5%, xanthan gum 0.01~0.5%, methyl propanediol 2~8%, glycerol
2~8%, EDETATE SODIUM 0.01~0.5%, water surplus.
The surfactant be preferably sodium acrylate/sodium acryloyldimethyl taurate copolymers, isohexadecane and
One of Polyoxyethylene Sorbitan Monooleate or at least two；More preferably sodium acrylate/sodium acryloyldimethyl taurate copolymers,
Isohexadecane and Polyoxyethylene Sorbitan Monooleate 7~8:4 in mass ratio~5:1~2 match obtained compound.
The emulsifier is preferably stearine/PEG-100 stearate.
The present invention has the following advantages and effects with respect to the prior art:
1. anti-aging peptide composition combination external source supplement elastin of the invention, inhibition nerve signal transmitting etc. are multiple
Mechanism rationally compounds each polypeptide functional component by the research of science under the premise of ensuring safety, can be realized collaboration and increases
Effect to reach optimal anti-ageing anti-wrinkle effect, and is used in compounding with other active matters and does not influence the anti-ageing of peptide composition
Old effect.
2. anti-aging peptide composition of the invention is added to lotion, cream, toner, Essence, facial mask as raw material
Or in the cosmetics such as freeze-dried powder, different use demands can be met.
3. anti-aging polypeptide freeze-dried powder of the invention, lotion and essence formula of liquid safe and reasonable, skin sense are excellent, effective component
Can rapid osmotic, there is good anti-ageing anti-wrinkle effect, and moisturizing significant effect, can maintain or improve moisturizing in skin because
Sub- content is effectively improved the water content of skin.
Detailed description of the invention
Fig. 1 is the skin elasticity test result figure of anti-aging polypeptide lotion and its control that embodiment 3 is prepared.
Fig. 2 is the skin flexibility test result figure of the anti-aging polypeptide Essence being prepared of embodiment 2 and its control.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
It will be appreciated that following embodiments and embodiment are merely to illustrate the present invention, and it is not construed as limiting the scope of the invention.It is not specified
Actual conditions person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer,
It is the conventional products that can be obtained by commercially available purchase.
In the formula for the peptide composition that embodiment of the present invention provides:
The synthesis of snare protein matter assembly is inhibited to can effectively avoid wrinkle caused by contraction of muscle.Muscle is receiving
Can be shunk when neurotransmitter, neurotransmitter is to synthesize in pericaryon, and be stored in synaptic versicle, when by
When environmental stimuli, snare protein matter assembly makes synaptic versicle release neurotransmitter, and reaches the postsynaptic through synaptic cleft
Film is had an effect in conjunction with corresponding receptor.Snare protein matter assembly be by three kinds of protein VAMP, Syntaxin and
What SNAP-25 was combined into.Argireline is the analogue of the SNAP-25 obtained by Molecular Simulation Technique, is led to
The position of competition SNAP-25 is crossed to inhibit the synthesis of snare protein matter assembly, passs muscle from effectively receiving nerve
Matter, contraction of muscle are restricted, and finally prevent skin wrinkle.Argireline used in the embodiment of the present invention is
Lipotec company, Spain
Advanced glycation endproducts AGEs is the reason of causing protein cross, and collagen and elastin laminin are sugared
Normal activity can be lost after base, caused skin to die down and followed the string.Glycosylation can be effectively suppressed in skin in acetyl group tetrapeptide -5
Generation in skin prevents aging to maintain collagen and elastin laminin bring normal extension and equivalent ability.This hair
Acetyl group tetrapeptide -5 used in bright embodiment is Spain Lipotec company
Elastin laminin is the important component of skin connection tissue, containing there are two types of special amino acid-desmosine and different locks
Chain element, both amino acid can with four polypeptide chains are radial is connected, different from other fibrins, elastin laminin can be with
It is stretched from both direction, more effectively supports skin.Elastin hydrolysis can directly facilitate and participate in the conjunction of dermal elastin
At the effect of being easily absorbed by the skin, can reach enhancing skin elasticity；Make the collagen increased activity of skin, keeps cutin water
Point, improve and reduce wrinkle from inside to outside, promotes compact sense.Elastin hydrolysis used in the embodiment of the present invention is that meaning is big
The Elastina Marina of sharp IRA Co., Ltd.
The sodium acrylate of surfactant used in the embodiment of the present invention/sodium acryloyldimethyl taurate copolymers are method
The SIMULGEL EG of Guo Sai BIC Corp (SEPPIC), the emulsifier glycerol stearate/PEG-100 stearate used are
The SIMULSOL 165 of France's match BIC Corp (SEPPIC).
Embodiment 1
Anti-aging polypeptide freeze-dried powder, formula are as shown in table 1.
Table 1
Preparation process: the material stirring of component A in table 1 is uniformly dissolved, and is then mixed with B group material, with Nang Shi filter
It filters (0.22 μm of filter sizes).It dispenses, jumps a queue after bottle placer debugging loading amount；It is lyophilized using freeze dryer, inlet, -45 DEG C
Booting pre-freeze 4 hours, primary distillation about 10 hours, secondary distillation about 9 hours shut down to unpack for 25~28 DEG C and offer for sale, vacuum tamponade,
Outlet, Zha Gai obtain anti-aging polypeptide freeze-dried powder.
Embodiment 2
Anti-aging polypeptide Essence, formula are as shown in table 2.
Table 2
Preparation process: according to the formula of table 2, component A being added in emulsion pot, is heated to 85 DEG C, and insulated and stirred 20 minutes,
Homogeneous 5 minutes, stirring sequentially added component B when being cooled to 45 DEG C, and stirring is cooled to 38 DEG C, filtering and discharging after quality inspection is qualified,
Obtain anti-aging polypeptide Essence.
Embodiment 3
Anti-aging polypeptide lotion, formula are as shown in table 3.
Table 3
Preparation process: according to the formula of table 3, component A is added in emulsion pot, is heated to 85 DEG C, insulated and stirred 20 minutes.
Oily phase pot is added in component B, is heated to 85 DEG C, insulated and stirred 10 minutes.Then component B is slowly pumped into emulsion pot, homogeneous 5
Minute, component C and homogeneous 2 minutes are added when cooling to 70 DEG C in stirring.It is slowly stirred uniformly, is cooled to 45 DEG C and sequentially adds group
Divide D, stir and be cooled to 38 DEG C, the filtering and discharging after quality inspection is qualified obtains anti-aging lotion.
4 anti-aging lotion efficacy test of embodiment
The present embodiment is that the anti-aging lotion that embodiment 3 obtains and its control sample (are not added with anti-ageing compared to embodiment 3
The product of old peptide composition) detection process and result.Test uses suction method, with constant negative pressure mode, i.e. test probe
Apply negative pressure in skin surface and skin sucked into probe aperture, skin deformation is restored after negative pressure disappears, skin deformation with negative pressure and when
Between variation can by tester emit light and receive light device measure.The device can reflect that skin is inhaled into depth, in this way
Skin stretch length time history plot can be obtained.Skin maximum tension amount is indicated with Uf, and Ue indicates that constant negative pressure adds
On to skin at 0.1 second dermoreaction amount of tension, Ur indicates that no negative pressure skin amount of recovery after 0.1 second, Uv=Uf-Ue are glutinous bullet
Property part (or be plastic amount of tension), Ua indicates to cancel the recovery of skin when negative pressure adds negative pressure to follow-on test next time again
Amount, R2=Ua/Uf, R2 are the parameter of a reflection skin elasticity, and the more big then skin elasticity of R2 value is better, closer to 1 elasticity
Better.
Test number is 40 people, is divided into 4 groups, every group of 10 people, test period is 28 days, using skin elasticity as test index.
Test method: before smearing sample, subject cleans face using identical mild detergent.In subject face
Left and right sides symmetric position selectes about 5 × 5cm2About 0.5g implementation is smeared on the left of face as Experimental Area in the region of size
The anti-aging polypeptide lotion of example 3 smears the control sample of equivalent on the right side of face.Control sample does not add anti-compared with embodiment
Aging peptide composition.Frequency of use is that once in the morning and once at night, continuous use daily avoids outdoor from being exposed to the sun.
Before using anti-aging polypeptide lotion of the invention, surveyed in test zone Reviscometer RV600 skin
It tries instrument and detects each experiment position elasticity R2 value, be repeated 5 times respectively, obtain average value.At this after smearing 7,14,21,28 days
The elastic R2 value of each detection zone is detected at a little positions respectively again, is repeated 5 times and finds out R2 average value.
The anti-aging polypeptide lotion and its control group that 40 subjects use embodiment 3 are measured by skin elasticity tester
Change with rear 7,14,21,28 days skin elasticities are used as shown in Figure 1, using the anti-ageing of embodiment 3 as shown in Figure 1 before sample
The elasticity of old polypeptide lotion rear face skin is relative to using the skin of control sample to be significantly increased.
5 anti-aging Essence efficacy test of embodiment
The present embodiment is that the anti-aging polypeptide Essence that embodiment 2 obtains and its control sample (do not add compared to embodiment 2
Add the product of Argireline in anti-aging peptide composition) detection process and result.Test uses suction method, with constant
Negative pressure mode, i.e. test probe apply negative pressure in skin surface and skin are sucked probe aperture, and skin deformation is restored after negative pressure disappears,
Skin deformation can be measured with negative pressure and time change by emitting light in tester and receiving the device of light.The device can reflect skin
Skin is inhaled into depth, and skin stretch length time history plot can be obtained in this way.Skin maximum tension amount is indicated with Uf,
Ue indicates the amount of tension of dermoreaction when constant negative pressure is added to 0.1 second on skin, and Ur indicates the skin recovery after 0.1 second of no negative pressure
Amount, Uv=Uf-Ue are viscoelasticity part (or being plastic amount of tension), and Ua indicates to cancel negative pressure to next follow-on test again
The amount of recovery of skin when adding negative pressure, R2=Ua/Uf, R2 are the parameter of a reflection skin elasticity, the more big then skin elasticity of R2 value
It is better, it is better closer to 1 elasticity.
Test number is 40 people, is divided into 4 groups, every group of 10 people, test period is 28 days, using skin elasticity as test index.
Test method: before smearing sample, subject cleans face using identical mild detergent.In subject face
Left and right sides symmetric position selectes about 5 × 5cm2About 0.5mL implementation is smeared on the left of face as Experimental Area in the region of size
The anti-aging polypeptide Essence of example 2 smears the control sample of equivalent on the right side of face.Control sample does not add compared with embodiment
Add the Argireline in anti-aging peptide composition.Frequency of use is that once in the morning and once at night, continuous use daily avoids outdoor
It is exposed to the sun.
Before using anti-aging polypeptide Essence of the invention, in test zone Reviscometer RV600 skin
Tester detects each experiment position elasticity R2 value, is repeated 5 times respectively, obtains average value.Smear 7,14,21,28 days after
The elastic R2 value of each detection zone is detected at these positions respectively again, is repeated 5 times and finds out R2 average value.
Anti-aging polypeptide Essence and its control of 40 subjects using embodiment 2 are measured by skin elasticity tester
Change with rear 7,14,21,28 days skin elasticities are used as shown in Fig. 2, using the essence of embodiment 2 as shown in Figure 2 before group sample
The elasticity of magnificent liquid rear face skin is relative to using the skin of control sample to be significantly increased.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a kind of anti-aging peptide composition, it is characterised in that: include Argireline, acetyl group tetrapeptide -5 and hydrolyzed elastin
Albumen；
The mass ratio of each ingredient is Argireline: acetyl group tetrapeptide -5 in the anti-aging peptide composition: hydrolysis
Elastin laminin=1~50:1~50:1~40.
2. anti-aging peptide composition according to claim 1, it is characterised in that: in the anti-aging peptide composition
The mass ratio of each ingredient is Argireline: acetyl group tetrapeptide -5: elastin hydrolysis=5~6:3~5:2~5.
3. anti-aging peptide composition according to claim 1, it is characterised in that: the anti-aging peptide composition is also
Include at least one of bacteriostatic agent and water.
4. a kind of anti-aging peptide composition freeze-dried powder, it is characterised in that: described in any item anti-ageing containing claims 1 to 3
Old peptide composition and lyophilization aid.
5. anti-aging peptide composition freeze-dried powder as claimed in claim 4 is preparing the application in cosmetics.
6. the described in any item anti-aging peptide compositions of claims 1 to 3 are preparing the application in cosmetics.
7. anti-aging peptide composition according to claim 6 is preparing the application in cosmetics, it is characterised in that:
Content of the anti-aging peptide composition in the cosmetics is mass percent 0.001~60%.
8. a kind of cosmetics with senile-resistant efficacy, it is characterised in that: by acceptable carrier on active constituent and cosmetics
Composition；Active constituent is that the described in any item anti-aging peptide compositions of claims 1 to 3 or 1~3 are described in any item
Anti-aging peptide composition is combined with other function substance；
The other function substance includes moisturizing substance, anti-ageing substance, compact substance, whitening material and antiallergy object
Matter.
9. a kind of anti-aging polypeptide Essence, it is characterised in that: contain the described in any item anti-aging polypeptides of claims 1 to 3
Composition.
10. a kind of anti-aging polypeptide lotion, it is characterised in that: contain the described in any item anti-aging polypeptide groups of claims 1 to 3
Close object.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910240664.8A CN109771323A (en) | 2019-03-28 | 2019-03-28 | A kind of anti-aging peptide composition and its application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910240664.8A CN109771323A (en) | 2019-03-28 | 2019-03-28 | A kind of anti-aging peptide composition and its application |
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| Publication Number | Publication Date |
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| CN109771323A true CN109771323A (en) | 2019-05-21 |
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ID=66490688
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| CN201910240664.8A Withdrawn CN109771323A (en) | 2019-03-28 | 2019-03-28 | A kind of anti-aging peptide composition and its application |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110192998A (en) * | 2019-07-12 | 2019-09-03 | 济南怡能食品科技有限公司 | It is a kind of repair anti-aging composition and its application |
| CN112494352A (en) * | 2020-12-22 | 2021-03-16 | 珠海伊斯佳科技股份有限公司 | Composition for resisting aging and repairing aged skin and preparation method and application thereof |
-
2019
- 2019-03-28 CN CN201910240664.8A patent/CN109771323A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110192998A (en) * | 2019-07-12 | 2019-09-03 | 济南怡能食品科技有限公司 | It is a kind of repair anti-aging composition and its application |
| CN112494352A (en) * | 2020-12-22 | 2021-03-16 | 珠海伊斯佳科技股份有限公司 | Composition for resisting aging and repairing aged skin and preparation method and application thereof |
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Application publication date: 20190521 |