CN109744248A - A kind of bactericidal composition containing benzothiostrobin and matrine - Google Patents

Abstract

The invention discloses a kind of bactericidal composition containing benzothiostrobin and matrine, benzothiostrobin and the weight ratio of matrine are 50:1-1:1 in the bactericidal composition, and bactericidal composition active constituent of the invention shows certain synergistic function between each other within the scope of aforementioned proportion.Bactericidal composition of the invention can be prepared into any one dosage form used in suitable agricultural production, including but not limited to any one in wettable powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, missible oil, seed treatment etc. by method known in Pesticide formulation.Bactericidal composition of the invention is worthy of popularization to crop safety.

Description

A kind of bactericidal composition containing benzothiostrobin and matrine

Technical field

The invention belongs to technical field of pesticide, and in particular to be a kind of Bactericidal composite containing benzothiostrobin and matrine Object and its purposes for preventing and treating corps diseases.

Background technique

With the promotion that the variation and pesticide of cropping system largely use, the fungicide kind of single active ingredient is agricultural That there are bactericidal ranges on bactericidal agent for preventing and treating is narrow, control efficiency is poor, application dosage is also easy to produce greatly phytotoxicity and drug resistance, application times Many drawbacks such as more, exacerbation environmental pollution, have clearly resulted in a large amount of underproduction of crops and being significantly increased for production cost.It is right In the resistance germ that agriculturally generates of prevention and treatment, a kind of method be release the new new component with existing cost without mutual resistance, but New effective component development cost is high, and the development cycle is long, and does not all catch up with the resistance speed of germ generation much.Others are arranged It applies such as crop structure adjustment, pesticide rotation to use, during practical operation, is difficult really to play apparent effect.

Benzothiostrobin is a kind of strobilurin fungicide of Central China Normal University's research and development, has sterilization The advantages that spectrum is wide, bactericidal activity is high, amount of application is low, the lasting period is long, has both therapeutic and protective effects, not only to cucumber downy mildew and Powdery mildew has good preventive effect, for scab, anthracnose, gray mold, corn southern leaf blight, false smut, banana blight, banana Sigatoka leaf spot disease has excellent inhibitory activity, but long-term be used alone easily makes disease develop drug resistance.

Matrine is root, stem and the fruit that noise made in coughing or vomiting leaf shrub kuh-seng (Sophora flavescens Ait) is fallen by pulse family Sophora A kind of water-soluble alkaloid extracted through stringent technique, appearance are brown homogeneous liquid.Generally Banlangen, master Ingredient is wanted to have matrine, oxymatrine, sophocarpine, N-Oxysophocarpine, Sophoridine etc..Platymiscium never poison, with tag for Main to have both stomach poison function, this product belongs to broad spectrum activity botanical pesticide, to fungies such as downy mildew, powdery mildew, anthracnose to people and animals' low toxicity Venereal disease evil tool greater activity.

Different pesticide active ingredients is combined, it is expected to improve preventive effect, but the composition pesticide of synergistic effect is often It is less, it is possible to reduce pesticide residue and environmental pollution, while the generation of pathogen drug resistance can also be delayed, it is to solve drug resistance One of major way of generation, through retrieving, currently, the related report that there is no discovery to be compounded about benzothiostrobin to matrine Road.

Summary of the invention

In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide a kind of control efficiency it is good, it is at low cost, can delay The Synergistic bactericidal composition that pathogen drug resistance generates.

Another object of the present invention is to provide the application of the bactericidal composition, the bactericidal composition is particularly suitable for Prevent and treat oomycetes diseases such as downy mildew, powdery mildew etc..

A method of prevention and treatment corps diseases, including by the sterilization of the present invention containing benzothiostrobin and matrine Composition successively, be administered simultaneously to crops or its growth environment.

In order to achieve the above object, the present invention adopts the following technical scheme:

A kind of bactericidal composition, its active constituent include at least benzothiostrobin and matrine, wherein benzothiostrobin and matrine Weight ratio be 50:1-1:1, further, the weight ratio of the benzothiostrobin and matrine is preferably 20:1-5:1.

Further, in the bactericidal composition the shared composition of effective component benzothiostrobin and matrine weight hundred Dividing content is 1-60%, preferably 5-40%.

Further, bactericidal composition of the invention also may include normal in Pesticide formulation in addition to effective component Supplementary costs, including but not limited to carrier and auxiliary agent are advised, it also may include other that the auxiliary agent, which includes at least a kind of surfactant, One of functional aid such as antifreezing agent, thickener, stabilizer, disintegrating agent, defoaming agent or more than one.

Further, bactericidal composition of the invention can be prepared into suitable by method known in Pesticide formulation Any one dosage form used in agricultural production, including but not limited to wettable powder, water dispersible granules, suspending agent, aqueous emulsion, Any one in microemulsion, missible oil, seed treatment etc..

Further, bactericidal composition of the invention can be provided in the form of finished product preparation, i.e., each substance has been in composition It through mixing, can also be provided with unit dose form, directly be mixed in proportion in bucket or tank using preceding, required for being then diluted to Concentration.

Further, other agricultural active ingredients, such as fungicide, desinsection can also be added in bactericidal composition of the invention One of agent, synergist, plant growth regulator, fertilizer etc. or more than one.

Compared with prior art, bactericidal composition of the invention has the beneficial effect that

1, active constituent benzothiostrobin and matrine compound in a certain proportion in bactericidal composition of the invention, synergy Effect is obvious, it is possible to reduce pesticide activity component usage amount improves control efficiency；

2, the active constituent mechanism of action is different in bactericidal composition of the invention, and the two compounding is conducive to action site increasing Add, is conducive to the generation for overcoming and/or delaying pathogen drug resistance；

3, bactericidal composition preparation process of the invention is simple, environmentally safe close friend.

Specific embodiment

In order to which the objectives, technical solutions, and advantages of the present invention of the invention are more clearly understood, the following tool of the present invention Body embodiment is illustrated, but the present invention is limited to absolutely not these examples.The following is only the preferred embodiment of the present invention, only It is used to explain the present invention, but cannot be therefore understands that being limitations on the scope of the patent of the present invention.It should be pointed out that all in the present invention Spirit and principle within made any modification, equivalent replacement or improvement etc., should be included in protection scope of the present invention it Interior, therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.

One, raw to survey embodiment

1, controlling object: cucumber downy mildew

2, after the effective inhibition concentration for determining benzothiostrobin and matrine is tested in prerun, two kinds of medicaments test method: are set not Same concentration is carried out referring to " farm-chemical indoor determination test rule fungicide ", measures medicament pair using mycelial growth rate method The virulence of crop germ measures colony diameter with crossing method after 72 h, calculates each processing net growth, mycelia growth inhibition Rate.Control efficiency is converted into probit value (y), and liquor strength (ug/mL) is converted into logarithm (x), and with minimum, multiplication calculates poison Concentration EC in power equation and inhibition₅₀, the toxicity index and co-toxicity coefficient (CTC) of medicament are calculated according to Sun Yunpei's Method.Test result is shown in Table 1.

As it can be seen from table 1 co-toxicity coefficient is all larger than when benzothiostrobin and matrine compound in the range of 50:1-1:1 120, synergistic function is shown to the prevention and treatment of cucumber downy mildew, especially when the two compound proportion is 20:1-1:5, altogether 150 or more, synergistic function becomes apparent from malicious coefficient.

Two, example of formulations

1, embodiment 1:21% benzothiostrobin aqueous matrine solution (20:1)

Benzothiostrobin 20%

Matrine 1%

Neopelex 4%

Sodium lignin sulfonate 5%

White carbon black 21%

Kaolin surplus

The wettable powder the preparation method comprises the following steps: by above-mentioned formula will active constituent be added carrier in, then be added dispersing agent, Wetting agent, mixing, remixes uniformly after air-flow crushing and can be prepared by wettable powder of the present invention.

2, embodiment 2:22.5% benzothiostrobin matrine missible oil (8:1)

Benzothiostrobin 20%

Matrine 2.5%

Agriculture breast 500# 4%

Cyclohexanone 30%

Dimethylbenzene surplus

The missible oil the preparation method comprises the following steps: by above-mentioned formula will effective component benzothiostrobin and matrine be added it is sufficiently molten after solvent Solution, other auxiliary agents, which are then added, after mixing evenly becomes homogeneous and transparent oily liquids, can be prepared by missible oil of the present invention Preparation.

3, embodiment 3:5.5% benzothiostrobin matrine suspending agent (10:1)

Benzothiostrobin 5%

Matrine 0.5%

Sodium lignin sulfonate 3%

Neopelex 2%

Aluminium-magnesium silicate 2%

Organic silicone 0.8%

Sodium benzoate 0.2%

Glycerine 3%

Deionized water surplus

The water dispersible granules the preparation method comprises the following steps: active constituent and other auxiliary agents are sequentially added mixer in the ratio of formula In, it is clipped to stir evenly, it can be prepared by suspending agent of the present invention.

4, embodiment 4:18% benzothiostrobin matrine water dispersible granule (5:1)

Benzothiostrobin 15%

Matrine 3%

Neopelex 3%

Alkylnaphthalene sulfonate formaldehyde condensation products 8%

Attapulgite surplus

The water dispersible granules the preparation method comprises the following steps: by active constituent and other auxiliary agents mix with use micro jet It crushes, is added in fluidized-bed granulation dryer after being granulated, drying, sieve, can be prepared by of the present invention after mediating Water dispersible granules.

Three, field control effectiveness test

In order to further verify the practical application effect of bactericidal composition of the invention, carried out using the medicament of the embodiment of the present invention Cucumber downy mildew field control effectiveness test is prevented and treated, using 20% benzothiostrobin suspending agent and 0.3% matrine missible oil as comparison medicament.

Test is carried out in Foshan City, the town Geng He, Gaoming District cucumber, tests application altogether twice, equivalent clear water is sprayed in check plot.Match When medicine, after first sufficiently being diluted medicament with a small amount of water, adds suitable quantity of water and carry out whole plant spray treatment, even spraying.Respectively at 7 days after last medicine, 14 days investigation disease indexs and preventive effect is calculated, test result is as shown in table 2.

Field control effectiveness test result is as shown in table 2, as can be seen from Table 2, to cucumber after benzothiostrobin and matrine compound The control efficiency of downy mildew is preferable, each embodiment after medicine the 7-14 days control efficiency to cucumber downy mildew 80% or more. In addition, not finding that the bactericidal composition has phytotoxicity generation to cucumber crop during application, it was demonstrated that bactericidal composition of the invention Safety is also preferable.

Claims (7)

1. a kind of bactericidal composition, which is characterized in that active constituent includes benzothiostrobin and matrine.

2. bactericidal composition according to claim 1, which is characterized in that the benzothiostrobin and the weight ratio of matrine are 50:1-1:1.

3. bactericidal composition according to claim 2, which is characterized in that the benzothiostrobin and the weight ratio of matrine are excellent It is selected as 20:1-5:1.

4. bactericidal composition according to claim 3, which is characterized in that the benzothiostrobin and the weight ratio of matrine are most Preferably 8:1.

5. bactericidal composition described in any one of -4 claims according to claim 1, which is characterized in that the Bactericidal composite The dosage form of object is wettable powder, water dispersible granules, suspending agent, aqueous emulsion, microemulsion, missible oil, any in seed treatment.

6. a kind of method for preventing and treating corps diseases, which is characterized in that including by any one of claim 1-4 claim institute That states is applied to the environment of crops or its growth.

7. according to the method described in claim 6, it is characterized in that, the corps diseases are preferably oomycetes diseases.