CN109730949A - It is a kind of with crease-resistant compact effect Medical-use cold compress pad pasting - Google Patents
It is a kind of with crease-resistant compact effect Medical-use cold compress pad pasting Download PDFInfo
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- CN109730949A CN109730949A CN201910161853.6A CN201910161853A CN109730949A CN 109730949 A CN109730949 A CN 109730949A CN 201910161853 A CN201910161853 A CN 201910161853A CN 109730949 A CN109730949 A CN 109730949A
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Abstract
The present invention provides a kind of with crease-resistant compact effect Medical-use cold compress pad pasting; it is made of following raw material: one group: water, glycerol, 1; 3 butanediols, glycine betaine, niacinamide, PEG/PPG-17/6 copolymer, adenosine, panthenol, polyquaternium -51,1,2- hexylene glycol, parahydroxyacet-ophenone, ammonium acryloyl taurate/VP copolymer, Sodium Hyaluronate, 3-o- ethylascorbyl, essence;Two groups: water, ginseng extract;Three groups: water, propylene glycol, licorice root extract, rough gentian root extract, kuh-seng root extract, cnidium monnieri berry extract, Artemisinin;Four groups: water, propylene glycol, nonyl phenol polyethers -14, PEG-50 castor oil, compared with prior art, the present invention is with following the utility model has the advantages that mildly non-stimulated to skin, the adverse reactions such as piloerection, shiver with cold will not be generated, sense of touch is comfortable, vaporization slowly continues, and sticking after effect time is 12 hours or more, has crease-resistant compact effect.
Description
Technical field
The present invention is a kind of with crease-resistant compact effect Medical-use cold compress pad pasting, belongs to the field of medical instrument technology.
Background technique
Cold compress is one of common physical therapy modalities.By reducing local tissue temperature, the local blood of contraction can achieve
Pipe, analgesia mitigate the multi-effects such as inflammatory swelling.For acute injury, the illness such as local inflammation, cold compress is widely used.Companion
With the development of modern biomedical, many new applications of cold compress are also constantly found, for example, existing research prompts, dermatological laser
In treatment, the generation of the discomfort and complication of patient is can be effectively reduced in postoperative cold compress in art;For another example, radiation therapy process
In, perienchyma's cold compress can significantly protect these tissues, reduce non-target site tissue damage, and then widen optional dosage water
It is flat, side reaction is reduced, patient compliance is promoted and better curative effect is provided.But technological progress is to the realization shape of cold compress itself
Formula also proposed new requirement.
Summary of the invention
In view of the deficienciess of the prior art, it is an object of the present invention to provide a kind of with crease-resistant compact effect Medical cold
Application film, to solve the problems mentioned in the above background technology.
To achieve the goals above, the present invention is to realize by the following technical solutions: a kind of with crease-resistant compact
Both effectiveness Medical-use cold compress pad pasting, is made of following raw material:
One group: water, glycerol, 1,3 butanediols, glycine betaine, niacinamide, PEG/PPG-17/6 copolymer, adenosine, panthenol, poly- season
Ammonium salt -51,1,2- hexylene glycol, parahydroxyacet-ophenone, ammonium acryloyldime-thyltaurate/VP copolymer, Sodium Hyaluronate, 3-
O- ethylascorbyl, essence;
Two groups: water, ginseng extract;
Three groups: water, propylene glycol, licorice root extract, rough gentian root extract, kuh-seng root extract, cnidium monnieri berry extract, sweet wormwood mention
Take object;
Four groups: water, propylene glycol, nonyl phenol polyethers -14, PEG-50 castor oil.
Further, niacin, boric acid and ammonium hydroxide are put into reaction pot, ammonia is passed through under stirring, then rising temperature for dissolving is distilled
Ammonia is recycled, continues to be concentrated until moving into dewatering pan after 120 °C, when temperature is up to being initially added into liquefied ammonia after 145 DEG C, and 185~190
Continue logical ammonia at DEG C and react 20~30h, is then cooled to 130 DEG C, distilled water is added to dilute, active carbon is added, and under 70-80 °C
Logical ammonia decolourizes 2h, filters while hot after reaction, filtrate in water cold analysis for 24 hours, separation crystallization, and with ethanol washing, dry raw material
In niacinamide.
Further, with ethyl alcohol extraction medicinal extract, face cream or resin, extract liquor is obtained, by obtained extract liquor through being subcooled
Jelly processing, filters off the impurity such as insoluble wax, then be evaporated under reduced pressure ethyl alcohol, obtains the essence in raw material.
Further, it takes the panax ginseng in jiljn of five leaves to cut off supporting root and fibrous root, washes, steam 2-3 hours, until ginseng root is in
Yellow, the skin shape that is translucent are advisable, and take out drying or dry, using the ginseng after the method extraction drying of supercritical extract, i.e.,
Obtain the ginseng extract in raw material.
Further, the dry aerial parts for taking compositae plant artemisia annua, pick weeds, dry in the shade in the case where keeping away positive environment, so
After be placed on environment temperature be 25-28 DEG C in the environment of, it is sun-dried, it is extracted using ultrasonic extraction, formed raw material in blueness
Parthenium extract.
Further, by taking the raw material of 100 parts by weight as an example: wherein:
In one group: water is 83.92 parts by weight, glycerol 3 is parts by weight, 1,3 butanediols are 2 parts by weight, glycine betaine be 2 parts by weight,
Niacinamide is 2 parts by weight, PEG/PPG-17/6 copolymer is 1 parts by weight, adenosine is 0.5 parts by weight, panthenol be 0.5 parts by weight,
Polyquaternium -51 is 0.5 parts by weight, 1,2- hexylene glycol is 0.5 parts by weight, parahydroxyacet-ophenone is 0.5 parts by weight, acryloyl two
N-methyltaurine ammonium/VP copolymer is 0.4 parts by weight, Sodium Hyaluronate is 0.05 parts by weight, 3-o- ethylascorbyl is 1
Parts by weight, essence are 0.03 parts by weight;
In two groups: water is 0.98 parts by weight, ginseng extract is 0.02 parts by weight;
In three groups: water is 0.65 parts by weight, propylene glycol is 0.3 parts by weight, licorice root extract is that 0.01 parts by weight, gentian mention
Taking object is 0.01 parts by weight, kuh-seng root extract is 0.01 parts by weight, cnidium monnieri berry extract is 0.01 parts by weight, Artemisinin
For 0.01 parts by weight;
In four groups: water is 0.025 parts by weight, propylene glycol is 0.02 parts by weight, nonyl phenol polyethers -14 are 0.03 parts by weight, PEG-
50 castor oil are 0.035 parts by weight.
Beneficial effects of the present invention: of the invention is a kind of with crease-resistant compact effect Medical-use cold compress pad pasting, to skin
It is mild non-stimulated, the adverse reactions such as piloerection, shiver with cold will not be generated, moisture content is up to 60% or more, and institute is aqueous close to human body cell
Part, colloid is soft, and sense of touch is comfortable, and vaporization slowly continues, and sticking after effect time is 12 hours or more, has crease-resistant tight
The effect of cause.
Specific embodiment
To be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, below with reference to
Specific embodiment, the present invention is further explained.
The present invention provides a kind of technical solution: it is a kind of with crease-resistant compact effect Medical-use cold compress pad pasting, by following original
Material is constituted:
One group: water, glycerol, 1,3 butanediols, glycine betaine, niacinamide, PEG/PPG-17/6 copolymer, adenosine, panthenol, poly- season
Ammonium salt -51,1,2- hexylene glycol, parahydroxyacet-ophenone, ammonium acryloyldime-thyltaurate/VP copolymer, Sodium Hyaluronate, 3-
O- ethylascorbyl, essence;
Two groups: water, ginseng extract;
Three groups: water, propylene glycol, licorice root extract, rough gentian root extract, kuh-seng root extract, cnidium monnieri berry extract, sweet wormwood mention
Take object;
Four groups: water, propylene glycol, nonyl phenol polyethers -14, PEG-50 castor oil.
Niacin, boric acid and ammonium hydroxide are put into reaction pot, ammonia is passed through under stirring, then rising temperature for dissolving is distilled to recover ammonia, until
It is moved into dewatering pan after 120 °C and continues to be concentrated, when temperature is up to being initially added into liquefied ammonia after 145 DEG C, and continued at 185~190 DEG C
Logical ammonia reacts 20~30h, is then cooled to 130 DEG C, distilled water is added to dilute, and active carbon is added, and leads to ammonia decoloration under 70-80 °C
2h is filtered while hot after reaction, filtrate in water cold analysis for 24 hours, separation crystallization, and with the nicotinoyl in ethanol washing, dry raw material
Amine.
With ethyl alcohol extraction medicinal extract, face cream or resin, extract liquor is obtained, obtained extract liquor is passed through into freezing processing, filter
The impurity such as insoluble wax are removed, then are evaporated under reduced pressure ethyl alcohol, obtain the essence in raw material.
It takes the panax ginseng in jiljn of five leaves to cut off supporting root and fibrous root, washes, steam 2-3 hours, until ginseng root is in yellow, Pi Cheng
It is translucent to be advisable, it takes out drying or dries, using the ginseng after the method extraction drying of supercritical extract to get in raw material
Ginseng extract.
The dry aerial parts for taking compositae plant artemisia annua, pick weeds, dry in the shade in the case where keeping away positive environment, are then placed within ring
It is sun-dried in the environment of border temperature is 25-28 DEG C, it is extracted using ultrasonic extraction, forms the Artemisinin in raw material.
As an embodiment of the present invention: by taking the raw material of 100 parts by weight as an example: wherein:
In one group: water is 83.92 parts by weight, glycerol 3 is parts by weight, 1,3 butanediols are 2 parts by weight, glycine betaine be 2 parts by weight,
Niacinamide is 2 parts by weight, PEG/PPG-17/6 copolymer is 1 parts by weight, adenosine is 0.5 parts by weight, panthenol be 0.5 parts by weight,
Polyquaternium -51 is 0.5 parts by weight, 1,2- hexylene glycol is 0.5 parts by weight, parahydroxyacet-ophenone is 0.5 parts by weight, acryloyl two
N-methyltaurine ammonium/VP copolymer is 0.4 parts by weight, Sodium Hyaluronate is 0.05 parts by weight, 3-o- ethylascorbyl is 1
Parts by weight, essence are 0.03 parts by weight;
In two groups: water is 0.98 parts by weight, ginseng extract is 0.02 parts by weight;
In three groups: water is 0.65 parts by weight, propylene glycol is 0.3 parts by weight, licorice root extract is that 0.01 parts by weight, gentian mention
Taking object is 0.01 parts by weight, kuh-seng root extract is 0.01 parts by weight, cnidium monnieri berry extract is 0.01 parts by weight, Artemisinin
For 0.01 parts by weight;
In four groups: water is 0.025 parts by weight, propylene glycol is 0.02 parts by weight, nonyl phenol polyethers -14 are 0.03 parts by weight, PEG-
50 castor oil are 0.035 parts by weight.
As an embodiment of the present invention: it is of the invention a kind of with crease-resistant compact effect Medical-use cold compress pad pasting,
It is mildly non-stimulated to skin, the adverse reactions such as piloerection, shiver with cold will not be generated, moisture content is up to 60% or more, close to human body cell institute
Water content, colloid is soft, and sense of touch is comfortable, and vaporization slowly continues, and sticking after effect time is 12 hours or more, has anti-
It wrinkles compact effect.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention, for this field skill
For art personnel, it is clear that invention is not limited to the details of the above exemplary embodiments, and without departing substantially from spirit of the invention or
In the case where essential characteristic, the present invention can be realized in other specific forms.Therefore, in all respects, should all incite somebody to action
Embodiment regards exemplary as, and is non-limiting, the scope of the present invention by appended claims rather than on state
Bright restriction, it is intended that including all changes that fall within the meaning and scope of the equivalent elements of the claims in the present invention
It is interior.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (6)
1. a kind of with crease-resistant compact effect Medical-use cold compress pad pasting, it is characterised in that: be made of following raw material:
One group: water, glycerol, 1,3 butanediols, glycine betaine, niacinamide, PEG/PPG-17/6 copolymer, adenosine, panthenol, poly- season
Ammonium salt -51,1,2- hexylene glycol, parahydroxyacet-ophenone, ammonium acryloyldime-thyltaurate/VP copolymer, Sodium Hyaluronate, 3-
O- ethylascorbyl, essence;
Two groups: water, ginseng extract;
Three groups: water, propylene glycol, licorice root extract, rough gentian root extract, kuh-seng root extract, cnidium monnieri berry extract, sweet wormwood mention
Take object;
Four groups: water, propylene glycol, nonyl phenol polyethers -14, PEG-50 castor oil.
2. according to claim 1 a kind of with crease-resistant compact effect Medical-use cold compress pad pasting, it is characterised in that: by cigarette
Acid, boric acid and ammonium hydroxide put into reaction pot, ammonia are passed through under stirring, then rising temperature for dissolving is distilled to recover ammonia, until moving into after 120 °C
Continue to be concentrated in dewatering pan, when temperature is up to being initially added into liquefied ammonia after 145 DEG C, and continue at 185~190 DEG C logical ammonia reaction 20~
Then 30h is cooled to 130 DEG C, distilled water is added to dilute, active carbon is added, and leads to ammonia decoloration 2h under 70-80 °C, takes advantage of after reaction
Heat filtering, filtrate in water cold analysis for 24 hours, separation crystallization, and with the niacinamide in ethanol washing, dry raw material.
3. according to claim 1 a kind of with crease-resistant compact effect Medical-use cold compress pad pasting, it is characterised in that: use second
Alcohol extracts medicinal extract, face cream or resin, obtains extract liquor, and obtained extract liquor is passed through freezing processing, filters off insoluble wax
Equal impurity, then it is evaporated under reduced pressure ethyl alcohol, obtain the essence in raw material.
4. according to claim 1 a kind of with crease-resistant compact effect Medical-use cold compress pad pasting, it is characterised in that: take five
The panax ginseng in jiljn of leaf cuts off supporting root and fibrous root, washes, and steams 2-3 hour, and to joining root in yellow, the skin shape that is translucent is
Preferably, it takes out drying or dries, extracted using the ginseng after the method extraction drying of supercritical extract to get the ginseng in raw material
Object.
5. according to claim 1 a kind of with crease-resistant compact effect Medical-use cold compress pad pasting, it is characterised in that: take chrysanthemum
The dry aerial parts of section's plant Artemisia annua, pick weeds, dry in the shade in the case where keeping away positive environment, and being then placed within environment temperature is 25-
It is sun-dried in the environment of 28 DEG C, it is extracted using ultrasonic extraction, forms the Artemisinin in raw material.
6. according to claim 1 a kind of with crease-resistant compact effect Medical-use cold compress pad pasting, it is characterised in that: with
For the raw material of 100 parts by weight: wherein:
In one group: water is 83.92 parts by weight, glycerol 3 is parts by weight, 1,3 butanediols are 2 parts by weight, glycine betaine be 2 parts by weight,
Niacinamide is 2 parts by weight, PEG/PPG-17/6 copolymer is 1 parts by weight, adenosine is 0.5 parts by weight, panthenol be 0.5 parts by weight,
Polyquaternium -51 is 0.5 parts by weight, 1,2- hexylene glycol is 0.5 parts by weight, parahydroxyacet-ophenone is 0.5 parts by weight, acryloyl two
N-methyltaurine ammonium/VP copolymer is 0.4 parts by weight, Sodium Hyaluronate is 0.05 parts by weight, 3-o- ethylascorbyl is 1
Parts by weight, essence are 0.03 parts by weight;
In two groups: water is 0.98 parts by weight, ginseng extract is 0.02 parts by weight;
In three groups: water is 0.65 parts by weight, propylene glycol is 0.3 parts by weight, licorice root extract is that 0.01 parts by weight, gentian mention
Taking object is 0.01 parts by weight, kuh-seng root extract is 0.01 parts by weight, cnidium monnieri berry extract is 0.01 parts by weight, Artemisinin
For 0.01 parts by weight;
In four groups: water is 0.025 parts by weight, propylene glycol is 0.02 parts by weight, nonyl phenol polyethers -14 are 0.03 parts by weight, PEG-
50 castor oil are 0.035 parts by weight.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112263501A (en) * | 2020-11-17 | 2021-01-26 | 上海辉文生物技术股份有限公司 | Multifunctional repairing and anti-aging composition containing thiotaurine and application thereof |
CN113116763A (en) * | 2019-12-31 | 2021-07-16 | 广州市科能化妆品科研有限公司 | Collagenase inhibitor, repair cream containing the same and preparation method thereof |
WO2023032869A1 (en) * | 2021-08-30 | 2023-03-09 | L'oreal | Transparent composition comprising polyhydroxy acid |
FR3127693A1 (en) * | 2021-10-05 | 2023-04-07 | L'oreal | TRANSPARENT COMPOSITION COMPRISING A POLYHYDROXYACID |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106473993A (en) * | 2016-12-10 | 2017-03-08 | 珍尔姿(广州)化妆品有限公司 | A kind of nourishing essence dew with crease-resistant effect |
CN106727113A (en) * | 2016-12-12 | 2017-05-31 | 珍尔姿(广州)化妆品有限公司 | A kind of sleep mask of long-acting moisturizing |
CN108420776A (en) * | 2018-06-07 | 2018-08-21 | 花安堂生物科技集团有限公司 | A kind of essence composition and the re-surface intensive wrinkle correct and preparation method thereof that compacts being made from it |
CN108938474A (en) * | 2018-09-28 | 2018-12-07 | 西藏大元草生物科技有限公司厦门分公司 | A kind of facial mask and preparation method thereof containing metallothionein of cordyceps sinensis |
CN109363997A (en) * | 2018-12-21 | 2019-02-22 | 广州欧盛化妆品有限公司 | A kind of deep water supplement moisturiser and preparation method |
-
2019
- 2019-03-04 CN CN201910161853.6A patent/CN109730949A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106473993A (en) * | 2016-12-10 | 2017-03-08 | 珍尔姿(广州)化妆品有限公司 | A kind of nourishing essence dew with crease-resistant effect |
CN106727113A (en) * | 2016-12-12 | 2017-05-31 | 珍尔姿(广州)化妆品有限公司 | A kind of sleep mask of long-acting moisturizing |
CN108420776A (en) * | 2018-06-07 | 2018-08-21 | 花安堂生物科技集团有限公司 | A kind of essence composition and the re-surface intensive wrinkle correct and preparation method thereof that compacts being made from it |
CN108938474A (en) * | 2018-09-28 | 2018-12-07 | 西藏大元草生物科技有限公司厦门分公司 | A kind of facial mask and preparation method thereof containing metallothionein of cordyceps sinensis |
CN109363997A (en) * | 2018-12-21 | 2019-02-22 | 广州欧盛化妆品有限公司 | A kind of deep water supplement moisturiser and preparation method |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113116763A (en) * | 2019-12-31 | 2021-07-16 | 广州市科能化妆品科研有限公司 | Collagenase inhibitor, repair cream containing the same and preparation method thereof |
CN113116763B (en) * | 2019-12-31 | 2023-10-27 | 广州市科能化妆品科研有限公司 | Collagenase inhibitor, repairing cream containing collagenase inhibitor and preparation method of repairing cream |
CN112263501A (en) * | 2020-11-17 | 2021-01-26 | 上海辉文生物技术股份有限公司 | Multifunctional repairing and anti-aging composition containing thiotaurine and application thereof |
WO2023032869A1 (en) * | 2021-08-30 | 2023-03-09 | L'oreal | Transparent composition comprising polyhydroxy acid |
FR3127693A1 (en) * | 2021-10-05 | 2023-04-07 | L'oreal | TRANSPARENT COMPOSITION COMPRISING A POLYHYDROXYACID |
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