CN109730321A - A kind of gel beads and preparation method thereof containing GPC - Google Patents
A kind of gel beads and preparation method thereof containing GPC Download PDFInfo
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- CN109730321A CN109730321A CN201811635418.4A CN201811635418A CN109730321A CN 109730321 A CN109730321 A CN 109730321A CN 201811635418 A CN201811635418 A CN 201811635418A CN 109730321 A CN109730321 A CN 109730321A
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- gel beads
- parts
- aqueous solution
- calcium
- glycerolphosphocholine
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Abstract
The gel beads and preparation method thereof containing GPC that the invention discloses a kind of, wherein the gel beads containing GPC include following components by weight: 1-100 parts of glycerolphosphocholine, 100 parts of water, 0.5-10 parts of sodium alginate.Place that purpose of the invention is to overcome the shortcomings in the prior art, it is eye-catching to provide a kind of beautiful appearance, convenient for taking, substantially the gel beads containing GPC for avoiding preservative antibacterial agent and excipients from adding, the gel beads mouthfeel and jelly, soft sweets are close, convenient for taking, it may be convenient to for treating and preventing cerebral infarction, Alzheimer disease and multi infarct dementia.
Description
Technical field
The invention belongs to health food, biomedicine technical field, in particular to a kind of gel beads and its preparation containing GPC
Method.
Background technique
L-a- glycerolphosphocholine (L-a-glyceryl phosphorylcholine, glycerolphosphocholine, GPC)
Also known as Choline Glycerophosphate.Glycerolphosphocholine is as drug or health care product for treating cerebral infarction, Alzheimer
Disease and multi infarct dementia have listed for many years in European & American Market and Japan, South Korea.To improvement senile dementia
Symptom, improves the elderly's survival ability and health quality has played extremely positive effect.
GPC sterling is a kind of white powder, there is the slightly sweet taste close with mannitol, water-soluble fine, can be to appoint with water
Meaning ratio is miscible.
Most GPC crystal forms all have apparent hygroscopicity, than more intractable in formulation process.
It is prepared into tablet or hard capsule, needs to be added more auxiliary material to solve the problems, such as that its moisture absorption deliquesces.
Aqueous solution is made in GPC, is filled into soft capsule, also has certain difficulty.And either solid system or flexible glue
Capsule preparation is taken more troublesome.Dilute GPC aqueous solution is easier to be absorbed to be easy to corrupt mildew by mushroom and algae,
Antiseptic and inhibiting bacteria function agent is added inevitably to ensure the validity period of product in the dosage form that oral aqueous solution form is made.
Moreover, it is contemplated that being mainly used for the specific symptoms such as Alzheimer disease, dementia to GPC, product forms appearance is eye-catching, has
Attraction, it should convenient for taking.
Summary of the invention
Place that purpose of the invention is to overcome the shortcomings in the prior art, it is eye-catching to provide a kind of beautiful appearance, is convenient for
It takes, avoids the gel beads containing GPC of preservative, antibacterial agent and excipients addition, which connects with jelly, soft sweets
Closely, convenient for taking, it may be convenient to for treating and preventing cerebral infarction, Alzheimer disease and multiple cerebral
Property it is dull-witted.
In order to achieve the above object, the present invention uses following scheme:
A kind of gel beads containing GPC, it is characterised in that by weight include following components:
1-100 parts of glycerolphosphocholine, 100 parts of water, 0.5-10 parts of sodium alginate.
It preferably, further include the sodium chloride of 0.1-5 parts by weight.
It preferably, further include the sweetener of 1-10 parts by weight.
Preferably, the sweetener is mannitol, stevioside, glycyrrhizic acid, disodium glycyrrhizinate, tripotassium glycyrrhetate and glycyrrhizic acid
One of trisodium.
It preferably, further include that the calcium saline solution that concentration is 1-5% is appropriate.
Preferably, the calcium saline solution is calcium chloride water, in calcium lactate aqueous solution, calcium gluconate aqueous solution
One or more kinds of mixtures.
It preferably, further include the pigment of 0.0001-0.1 parts by weight.
A kind of preparation method of the gel beads containing GPC of the present invention, it is characterised in that the following steps are included:
A, glycerolphosphocholine is dissolved into the water, glycerolphosphocholine aqueous solution is made；
B, sodium alginate and sodium chloride are added in the glycerolphosphocholine aqueous solution in step A, obtain mixed liquor；
C, the mixed liquor in step B is dripped in the aqueous solution of calcium salt and spherical gel beads is made, gel beads are filtered in filtering
Out to get.
Preferably, it is dissolved at 50-60 DEG C in step A.
Preferably, the size of the gel beads is 5-10 mesh.
Preferably, the diameter of the gel beads is 0.5-2cm.
In conclusion the present invention compared with the existing technology the beneficial effect is that:
One, gel beads prepared by the present invention are glistening spherical hydrogel, beautiful appearance, it may be convenient to which addition is few
Amount edible essence and pigment are adjusted to various colors.
Two, gel beads size prepared by the present invention adjusts in which can be convenient, and the hardness of gel beads can also pass through tune
The concentration of whole sodium alginate and calcium salt adjusts, it is easy to prepare the extremely agreeable to the taste GPC aqueogel of soft or hard size.
Three, gel beads stability of the present invention preparation containing GPC is relatively good, and appropriate closed preservation several months, GPC are effective at room temperature
Component content is not substantially reduced.
Four, in the present invention, gel process induces gel using calcium salt, and a small amount of calcium ion exists in the form of calcium alginate
In gel, certain calcium supplementing effect can be played to the elderly.
Specific embodiment
The invention will be further described With reference to embodiment:
Embodiment 1
L-a- glycerolphosphocholine (GPC) sterling 20g, is dissolved in purified water 100g, stirs evenly.
Sodium alginate 3g is added in above-mentioned aqueous solution, stirring and dissolving.50 degrees Celsius can be warming up to suitably to accelerate
Dissolution.
Above-mentioned mixed liquor is added drop-wise in 2% calcium chloride water, the gel beads of 5 to 10 mesh are made in drop.
Filtering, gel beads are filtered out to get the gel beads containing GPC.
The gel beads character rounding, bright sparkling and crystal-clear, colourless, mouthfeel has slightly sweet taste similar to jelly, convenient to take agreeable to the taste.
Embodiment 2
L-a- glycerolphosphocholine (GPC) sterling 20g, is dissolved in purified water 100g, stirs evenly.
Sodium alginate 3g is added in above-mentioned aqueous solution, stirring and dissolving.60 degrees Celsius can be warming up to suitably to accelerate
Dissolution.
Above-mentioned mixed liquor is added drop-wise in 3% calcium lactate aqueous solution, the gel beads that average grain diameter is 1 centimetre are made in drop.
Filtering, gel beads are filtered out to get the gel beads containing GPC.
The gel beads character rounding, particle diameter distribution is uniform, and bright sparkling and crystal-clear, mouthfeel has slightly sweet taste similar to jelly, convenient to take
It is agreeable to the taste.
Embodiment 3
L-a- glycerolphosphocholine (GPC) sterling 10g, is dissolved in purified water 100g, stirs evenly.
Sodium alginate 3g, sodium chloride 1g are added in above-mentioned aqueous solution, stirring and dissolving.It is Celsius that 53 can be suitably warming up to
Degree is to accelerate to dissolve.
Above-mentioned mixed liquor is added drop-wise in 3% calcium gluconate aqueous solution, the gel beads of 5 to 10 mesh are made in drop.
Filtering, gel beads are filtered out to get the gel beads containing GPC.
The gel beads character rounding, bright sparkling and crystal-clear, mouthfeel has slightly sweet taste similar to jelly, convenient to take agreeable to the taste.
Embodiment 4
L-a- glycerolphosphocholine (GPC) sterling 15g, mannitol 5g are dissolved in purified water 100g, stir evenly.
By sodium alginate 3g, it is added in above-mentioned aqueous solution, stirring and dissolving.55 degrees Celsius can be warming up to suitably to accelerate
Dissolution.
Above-mentioned mixed liquor is added drop-wise in 3% calcium gluconate aqueous solution, the gel beads of 5 to 10 mesh are made in drop.
Filtering, gel beads are filtered out to get the gel beads containing GPC.
The gel beads character rounding, bright sparkling and crystal-clear, mouthfeel has slightly sweet taste similar to jelly, convenient to take agreeable to the taste.
Embodiment 5
L-a- glycerolphosphocholine (GPC) sterling 15g, mannitol 10g are dissolved in purified water 100g, stir evenly.
By sodium alginate 3g, it is added in above-mentioned aqueous solution, stirring and dissolving.58 degrees Celsius can be warming up to suitably to accelerate
Dissolution.
Above-mentioned mixed liquor is added drop-wise in 3% calcium gluconate aqueous solution, the gel beads of 20 to 30 mesh are made in drop.
Filtering, gel beads are filtered out to get the gel beads containing GPC.
The gel beads character rounding, bright sparkling and crystal-clear, mouthfeel has slightly sweet taste similar to jelly, convenient to take agreeable to the taste.
Embodiment 6
A kind of gel beads containing GPC, it is characterised in that by weight include following components:
1 part of glycerolphosphocholine, 100 parts of water, 0.5 part of sodium alginate, 0.1 part of sodium chloride, 1 part of sweetener, pigment
0.0001 part, the calcium saline solution that concentration is 1% is appropriate.The sweetener is mannitol.The calcium saline solution is calcium chloride
Aqueous solution.
Preparation method, comprising the following steps:
A, by glycerolphosphocholine, sweetener, pigment into the water, dissolved at 50 DEG C, glycerophosphatide acyl gallbladder be made
Aqueous alkali；
B, sodium alginate and sodium chloride are added in the glycerolphosphocholine aqueous solution in step A, obtain mixed liquor；
C, the mixed liquor in step B is dripped in the aqueous solution of calcium salt and spherical gel beads is made, gel beads are filtered in filtering
Out to get.Wherein the size of the gel beads is 5-10 mesh.
Embodiment 6
A kind of gel beads containing GPC, it is characterised in that by weight include following components:
100 parts of glycerolphosphocholine, 100 parts of water, 10 parts of sodium alginate, 5 parts of sodium chloride, 10 parts of sweetener, pigment 0.1
Part, the calcium saline solution that concentration is 5% is appropriate.The sweetener is stevioside.The calcium saline solution is calcium lactate aqueous solution.
Preparation method, comprising the following steps:
A, by glycerolphosphocholine, sweetener, pigment into the water, dissolves at 60 DEG C, and glycerophosphatide acyl gallbladder is made
Aqueous alkali；
B, sodium alginate and sodium chloride are added in the glycerolphosphocholine aqueous solution in step A, obtain mixed liquor；
C, the mixed liquor in step B is dripped in the aqueous solution of calcium salt and spherical gel beads is made, gel beads are filtered in filtering
Out to get.Wherein the diameter of the gel beads is 1-2cm.
Embodiment 7
A kind of gel beads containing GPC, it is characterised in that by weight include following components:
50 parts of glycerolphosphocholine, 100 parts of water, 3 parts of sodium alginate, 2 parts of sodium chloride, 5 parts of sweetener, pigment 0.001
Part, the calcium saline solution that concentration is 2% is appropriate.The sweetener is tripotassium glycyrrhetate.The calcium saline solution is calcium chloride water
The mixture of solution and calcium gluconate aqueous solution.
Preparation method, comprising the following steps:
A, by glycerolphosphocholine, sweetener, pigment into the water, dissolves at 55 DEG C, and glycerophosphatide acyl gallbladder is made
Aqueous alkali；
B, sodium alginate and sodium chloride are added in the glycerolphosphocholine aqueous solution in step A, obtain mixed liquor；
C, the mixed liquor in step B is dripped in the aqueous solution of calcium salt and spherical gel beads is made, gel beads are filtered in filtering
Out to get.Wherein the size of the gel beads is 5-10 mesh.
Basic principles and main features and advantages of the present invention of the invention have been shown and described above.The skill of the industry
Art personnel it should be appreciated that the present invention is not limited to the above embodiments, the above embodiments and description only describe
The principle of the present invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these
Changes and improvements all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and
Its equivalent thereof.
Claims (10)
1. a kind of gel beads containing GPC, it is characterised in that by weight include following components:
1-100 parts of glycerolphosphocholine, 100 parts of water, 0.5-10 parts of sodium alginate.
2. a kind of gel beads containing GPC according to claim 1, it is characterised in that further include the chlorination of 0.1-5 parts by weight
Sodium.
3. a kind of gel beads containing GPC according to claim 1 or 2, it is characterised in that further include the sweet tea of 1-10 parts by weight
Taste agent.
4. a kind of gel beads containing GPC according to claim 3, it is characterised in that the sweetener is mannitol, stevia rebaudianum
One of sugar, Radix Glycyrrhizae, disodium glycyrrhizinate, tripotassium glycyrrhetate and trisodium glycyrrhetinate.
5. a kind of gel beads containing GPC according to claim 1 or 2, it is characterised in that further include the calcium that concentration is 1-5%
Appropriate saline solution.
6. a kind of gel beads containing GPC according to claim 5, it is characterised in that the calcium saline solution is calcium chloride water
The mixture of one or more of solution, calcium lactate aqueous solution, calcium gluconate aqueous solution.
7. a kind of gel beads containing GPC according to claim 1 or 2, it is characterised in that further include 0.0001-0.1 weight
The pigment of part.
8. a kind of preparation method of the gel beads containing GPC, it is characterised in that the following steps are included:
A, glycerolphosphocholine is dissolved into the water, glycerolphosphocholine aqueous solution is made；
B, sodium alginate and sodium chloride are added in the glycerolphosphocholine aqueous solution in step A, obtain mixed liquor；
C, the mixed liquor in step B to be dripped in the aqueous solution of calcium salt and spherical gel beads is made, filtering filters out gel beads,
To obtain the final product.
9. preparation method according to claim 7, it is characterised in that dissolved at 50-60 DEG C in step A.
10. preparation method according to claim 7, it is characterised in that the size of the gel beads is 5-10 mesh or described solidifying
The diameter of glue bead is 1-2cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811635418.4A CN109730321A (en) | 2018-12-29 | 2018-12-29 | A kind of gel beads and preparation method thereof containing GPC |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811635418.4A CN109730321A (en) | 2018-12-29 | 2018-12-29 | A kind of gel beads and preparation method thereof containing GPC |
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| CN109730321A true CN109730321A (en) | 2019-05-10 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114698769A (en) * | 2022-03-15 | 2022-07-05 | 大连工业大学 | Method for immobilizing black pigment of agaric and application of agaric in preparation of jelly |
Citations (4)
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|---|---|---|---|---|
| CN102908336A (en) * | 2011-08-05 | 2013-02-06 | 深圳市华正实业有限公司 | Stable preparation of phosphatidylserine and preparation method, application as well as application product of stable preparation |
| CN103202469A (en) * | 2013-03-28 | 2013-07-17 | 吉林大学 | Egg yolk lecithin microcapsules and preparation method thereof |
| CN103919715A (en) * | 2013-01-14 | 2014-07-16 | 柏法迪斯有限公司 | Controlled Release Drug Combination Containing Choline Alfoscerate Or Salt Thereof And Method For Preparing Same |
| CN108295045A (en) * | 2018-03-16 | 2018-07-20 | 武汉百纳礼康生物制药有限公司 | A kind of gel with liquid crystal structure micro-capsule and preparation method thereof |
-
2018
- 2018-12-29 CN CN201811635418.4A patent/CN109730321A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908336A (en) * | 2011-08-05 | 2013-02-06 | 深圳市华正实业有限公司 | Stable preparation of phosphatidylserine and preparation method, application as well as application product of stable preparation |
| CN103919715A (en) * | 2013-01-14 | 2014-07-16 | 柏法迪斯有限公司 | Controlled Release Drug Combination Containing Choline Alfoscerate Or Salt Thereof And Method For Preparing Same |
| CN103202469A (en) * | 2013-03-28 | 2013-07-17 | 吉林大学 | Egg yolk lecithin microcapsules and preparation method thereof |
| CN108295045A (en) * | 2018-03-16 | 2018-07-20 | 武汉百纳礼康生物制药有限公司 | A kind of gel with liquid crystal structure micro-capsule and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114698769A (en) * | 2022-03-15 | 2022-07-05 | 大连工业大学 | Method for immobilizing black pigment of agaric and application of agaric in preparation of jelly |
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Application publication date: 20190510 |