CN109718341A - A kind of Chinese medicine composition for treating aseptic necrosis of femoral head - Google Patents
A kind of Chinese medicine composition for treating aseptic necrosis of femoral head Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine compositions for treating aseptic necrosis of femoral head, belong to field of medicaments.The Chinese medicine composition is prepared by Radix Astragali, honeysuckle, Cortex Phellodendri, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba, semen coicis etc..Pharmacodynamics test shows that the present composition causes rabbit aseptic necrosis of femoral head to improve significantly dexamethasone, while clinical test shows that the present composition has significant therapeutic effect for aseptic necrosis of femoral head.Comprehensively, toxic side effect is low for effect when the Chinese medicine composition is for treating aseptic necrosis of femoral head, and therapeutic effect is better than existing therapeutic agent, has a vast market foreground.
Description
Technical field
The present invention relates to a kind of Chinese medicine compositions for treating aseptic necrosis of femoral head, belong to field of medicaments.
Background technique
Aseptic necrosis of femoral head (ANFH) cause of disease mainly includes traumatic and atraumatic two major classes.Traumatic agent was once
Through the primary pathogenic factors for the disease, as the improvement of people's living standards, the ratio of atraumatic factor is increasing year by year, at
The main reason for for the disease incidence mainly includes hormone, alcohol, genetic factors and other unknown factors.These factors are common
Final result be femoral head effective blood supply interruption, cause the active constituent of bone dead and then repair a series of
Complicated pathologic process.Related theory mainly includes blood stagnation theory, and bone marrow stroma stem cell (BMSC) is different to fat cell
Often differentiation theory, apoptosis of bone cells theory, the theories such as osteoporosis theory and disorders of lipid metabolism, their common features are to supply
It answers the important blood vessels of femoral head because of mechanical reason, manages outer compressing and Intravascular Thrombus embolism and blocked, it is final to occur
The necrosis of osteocyte.
The natural history of caput femoris necrosis is different from other typical osteonecrosis, and rigid onset when may not there be correlation
Clinical symptoms, but after symptom occurs, be in progress often quickly.A large amount of document shows not by the femoral head for the treatment of
Necrosis has at least 80% patient to collapse in 4 years.Exempt from weight bearing treatment and is very important a method.Caput femoris necrosis
The method for the treatment of mainly according to disease by stages with the selection of operative doctor.Mainly there are drug therapy, core decompression, marrow core at present
Decompression is with structure and cell support, various osteotomies, femoral head surface substitutive and total hip replacement etc..
Train of thought Shutong granules are the three classes Chinese patent drugs for treating thrombophlebitis, and prescription and preparation method have obtained China
Patent of invention (Authorization Notice No.: CN1201787C) has the effect of clearing heat and detoxicating, disperse blood stasis and dredge collateral, clearing damp detumescence, for damp and hot
Superficial thrombophlebitis caused by stasis blocking train of thought, lower limb swelling, pain, skin caused by non-acute phase Deep vain thrombosis
Color is dark red or with streak object.Prescription by Radix Astragali, honeysuckle, Cortex Phellodendri, rhizoma atractylodis, semen coicis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba, Radix Glycyrrhizae,
Leech, centipede, 12 taste Chinese medicinal composition of scorpio, have merged the Simiao San with clearing heat and expelling damp function, and there is clearing heat and detoxicating, promoting blood circulation to stop
The Simiao Yongan Tang of pain function, have removing toxic substances search pick, the Zhijing San of relieving convulsion dissipating bind effect, have emergency solution contraction, relieving pain by regulating nutrient QI work
Peony and licorice decoction and the danggui buxue decoction with benefiting qi for promoting production of blood function etc. treat the recipe of thrombotic diseases.It is followed
The advantage of all sides compensates for the deficiency of original side, brings out the best in each other, and left and right is taken into account.
So far, Guan pulse network Shutong granules treatment aseptic necrosis of femoral head bioactivity or clinical application side be there are no
The research in face.
Summary of the invention
The object of the present invention is to provide a kind of new applications of Chinese medicine composition, especially treat aseptic femoral head in preparation
New application in necrosis especially Alcoholic aseptic necrosis of femoral head or steroid femur head necrosis drug.The Chinese medicine composition
The patented authorization (Authorization Notice No.: CN1201787C) on May 18th, 2005, the Chinese medicine composition is by containing Huang
The kinds of traditional Chinese medicines such as stilbene, honeysuckle, Cortex Phellodendri, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba, semen coicis are prepared.The Chinese medicine composition is used for
Comprehensively, toxic side effect is low for effect when treating aseptic necrosis of femoral head, and therapeutic effect is better than existing therapeutic agent, has wide
Market prospects.
In above-mentioned Chinese medicine composition, the Radix Astragali, honeysuckle, Cortex Phellodendri, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba and semen coicis weight
Measure part are as follows:
Radix Astragali 300-700 honeysuckle 300-700 Cortex Phellodendri 100-400
Rhizoma atractylodis 100-400 radix scrophulariae 300-700 Radix Angelicae Sinensis 100-400
Radix Paeoniae Alba 100-400 semen coicis 300-700.
Also contain centipede, scorpio, leech and licorice raw material medicine in the Chinese medicine composition；Preferably, the centipede, complete
The parts by weight of scorpion, leech and Radix Glycyrrhizae are as follows: centipede 10-40, scorpio 50-100, leech 180-280, Radix Glycyrrhizae 50-100.
The parts by weight of each bulk pharmaceutical chemicals in the Chinese medicine composition are as follows:
One of it is preferred that, the parts by weight of each bulk pharmaceutical chemicals in the Chinese medicine composition are as follows:
It is preferred that two, the parts by weight of each bulk pharmaceutical chemicals in the Chinese medicine composition are as follows:
Radix Astragali, semen coicis, Radix Angelicae Sinensis have effects that invigorating qi for consolidating superficies, replenishing and activating blood, gold and silver in the traditional chinese medicine composition of the invention side
Flower, Cortex Phellodendri, radix scrophulariae, rhizoma atractylodis have effects that heat-clearing and damp-drying drug, purging fire for removing toxin, and Radix Paeoniae Alba, scorpio, centipede have relieving convulsion and spasm, attack poison
Dissipating bind, the effect of removing obstruction in channels to relieve pain, leech has effects that dissipating blood stasis with potent drugs, promoting menstruation.All medicine cooperations, strengthen heat-clearing and damp-drying drug, promoting blood circulation
Stagnation resolvation, swelling and pain relieving function.
Pharmacology pharmacodynamic and clinical test show pharmacodynamics test show the present composition to dexamethasone cause rabbit without
Bacterium property caput femoris necrosis improves significantly, and the present composition significantly improves femoral head and lumbar spine bmd and Bones morphology
Metering, femoral head and lumbar vertebrae biomechanics of bone significantly reduce nucleic skeletal imaging ROI value, and indices improve significantly, while clinical examination
It tests and shows that the present composition has significant therapeutic effect to aseptic necrosis of femoral head.The Chinese medicine composition is sterile for treating
Property caput femoris necrosis when effect comprehensively, toxic side effect is low, therapeutic effect be better than existing therapeutic agent, before having a vast market
Scape.
Another object of the present invention is to provide the preparation method of above-mentioned Chinese medicine composition.Using the above-mentioned Chinese medicine of the present invention as original
Material, the different auxiliary material being pharmaceutically commonly used is added can be by medicine preparation of the present invention at different clinics using common process
Pharmaceutical dosage form, it is preferred that it is prepared into pill, granule, capsule, tablet, oral solution, masticatory, dripping pill or emulsion, it is optimal
Choosing, granule.The customary pharmaceutical excipients that drug of the present invention is added as needed can with disintegrating agent, dispersing agent, lubricant,
Diluent, preservative, colorant, corrigent etc. one or more of are worked as.
Another object of the present invention is to provide the preparation method of above-mentioned Chinese medicine composition.The system of the above-mentioned Chinese medicine composition
Preparation Method includes the following steps:
1) add water to shift to an earlier date volatile oil honeysuckle, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba, obtain the dregs of a decoction, medical fluid and volatile oil；
2) volatile oil obtained by step 1) is added into dehydrated alcohol, is uniformly mixed, obtains ethyl alcohol volatile oil solution；
3) Radix Astragali, Cortex Phellodendri, semen coicis, Radix Glycyrrhizae and 1/2 recipe quantity leech, centipede, scorpio and step 1) the gained dregs of a decoction are taken
It adds water to cook, filters to obtain decoction liquor, decoction liquor merges concentration, alcohol precipitation after concentrate is cooling with step 1) medical fluid；After alcohol precipitation
Supernatant liquid filtering recycles ethyl alcohol, is concentrated under reduced pressure into medicinal extract；
4) leech, centipede, the scorpio of remaining 1/2 recipe quantity are crushed into obtain medicinal powder, medicinal extract obtained by medicinal powder, step 2) is mixed
It is even, through normal process steps directly or pharmaceutically acceptable excipient is added clinically-acceptable dosage form is made.
Preferably, volatile oil described in step 1) is prepared into volatile oil betadex inclusion compound.
Preferably, step 2) is by extract dry at dry powder.
Preferably, the step 3) leech, centipede, scorpio are pulverized, the grain it is highly preferred that gained Ultramicro-powder is averaged
Diameter is less than 75 μm.
Particularly, the method for preparing above-mentioned Chinese medicine composition includes:
1) extracting honeysuckle, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba, which are placed in multi-function extractor, carries out steam distillation, obtains medicine
Slag, medical fluid and volatile oil crude product, redistillation, obtain the dregs of a decoction, medical fluid and refined volatile oil；
2) refined volatile oil obtained by step 1) is added into dehydrated alcohol, is uniformly mixed, obtains ethyl alcohol volatile oil solution, set closed appearance
Storage in device；
3) Radix Astragali, Cortex Phellodendri, semen coicis, Radix Glycyrrhizae and 1/2 recipe quantity leech, centipede, scorpio and step 1) the gained dregs of a decoction are taken
It adds water to cook 1-3 times, 1-3 hours each, collecting decoction, filters, take medical fluid obtained by step 1) to merge concentration therewith, add after cooling
It ethyl alcohol standing 12 hours or more, is allowed to sufficiently precipitate；By the supernatant liquid filtering after alcohol precipitation, ethyl alcohol is recycled, is concentrated under reduced pressure into medicinal extract；
4) leech, centipede, the scorpio of remaining 1/2 recipe quantity are ground into fine powder, by medicinal extract obtained by fine powder, step 2) and medicine
With auxiliary materials and mixing, ethyl alcohol is added as wetting agent, softwood is made, enters the drying of boiling type drying bed, spray volatile oil ethanol solution, most
By normal process steps directly or pharmaceutically acceptable excipient is added clinically-acceptable dosage form is made.
Preferably, currently preferred dosage form is granule, by above-mentioned Chinese medicine composition be prepared into granule method it
One includes:
1) extracting honeysuckle, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba, which are placed in multi-function extractor, carries out steam distillation, obtains medicine
Slag, medical fluid and volatile oil crude product；It will volatilize oily crude product redistillation, obtain refined volatile oil；
2) refined volatile oil obtained by step 1) is added into dehydrated alcohol, is uniformly mixed, obtains ethyl alcohol volatile oil solution, set closed appearance
Storage in device；
3) Radix Astragali, Cortex Phellodendri, semen coicis, Radix Glycyrrhizae and 1/2 recipe quantity leech, centipede, scorpio and step 1) the gained dregs of a decoction are taken
It adds water to cook 1-3 times, 1-3 hours each, collecting decoction, filters, take medical fluid obtained by step 1) to merge concentration therewith, add after cooling
It ethyl alcohol standing 12 hours or more, is allowed to sufficiently precipitate, by the supernatant liquid filtering after alcohol precipitation, recycles ethyl alcohol, be concentrated under reduced pressure into medicinal extract；
4) leech, centipede, the scorpio of remaining 1/2 recipe quantity are ground into fine powder, by medicinal extract obtained by fine powder, step 2) and
The pharmaceutic adjuvants such as Icing Sugar and dextrin mix by a certain percentage, ethyl alcohol are added as wetting agent, softwood is made, it is dry to enter boiling type drying bed
It is dry, volatile oil ethanol solution is sprayed, finally directly or pharmaceutically acceptable excipient is added through normal process steps, particle is made
Agent.
Two that above-mentioned Chinese medicine composition is prepared into the method for granule include:
1) after being cleaned by three kinds of leech of 1/2 recipe quantity, centipede, scorpio animal drugs, wash, sterilize, be dried, into
Row pulverizes, and gained Ultramicro-powder average grain diameter is less than 75 μm；
2) by honeysuckle, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba extracting in water volatile matter distillation oil, the dregs of a decoction, medical fluid and volatile oil are obtained；
3) volatile oil obtained by step 1) is added into dehydrated alcohol, is uniformly mixed, obtains volatile oil ethanol solution；
4) dregs of a decoction obtained by step 2) are together with Radix Astragali, Cortex Phellodendri, semen coicis, Radix Glycyrrhizae and 1/2 recipe quantity leech, centipede, scorpio
Extraction is added water to cook, is concentrated after Aqueous extracts filtering plus ethyl alcohol turns molten essence and mentions, is condensed into the water extracted immersing paste again；
5) Ultramicro-powder obtained by step 1) is first stirred with the water extracted immersing paste obtained by step 4) to add appropriate granulation liquid mixed
Stirring granulation is closed, dry, whole grain sprays into volatile oil ethanol solution obtained by step 3), through particles packing machine sealed package after mixing,
Particle is made.
Three that above-mentioned Chinese medicine composition is prepared into the method for granule include:
1) after being cleaned by three kinds of leech of 1/2 recipe quantity, centipede, scorpio animal drugs, wash, sterilize, be dried, surpass
Crushing of Ultrafine, gained Crushing of Ultrafine average grain diameter is less than 75 μm；
2) by honeysuckle, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba extracting in water volatile oil, the dregs of a decoction, medical fluid and volatile oil are obtained；
3) volatile oil obtained by step 2) is added into dehydrated alcohol, is uniformly mixed, obtains volatile oil ethanol solution；
4) dregs of a decoction obtained by step 2) are together with Radix Astragali, Cortex Phellodendri, semen coicis, Radix Glycyrrhizae and 1/2 recipe quantity leech, centipede, scorpio
Extraction is added water to cook, is concentrated after Aqueous extracts filtering plus ethyl alcohol turns molten essence and mentions, is condensed into the water extracted immersing paste again；
5) the water extracted immersing paste obtained by Ultramicro-powder obtained by step 1) and step 4) and appropriate granulation liquid will be mixed and will be pelletized, done
Dry, whole grain sprays into volatile oil ethanol solution obtained by step 3) through particles packing machine sealed package after mixing and particle is made.
Another preferred dosage form of the invention is pill, and preparation method includes:
1) extracting honeysuckle, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba, which are placed in multi-function extractor, carries out steam distillation, obtains medicine
Slag, medical fluid and volatile oil crude product；It will volatilize oily crude product redistillation, obtain refined volatile oil；
2) refined volatile oil obtained by step 1) is prepared into volatile oil betadex inclusion compound, sets storage in closed container；
3) medicine obtained by leech, centipede, scorpio and the step 1) of Radix Astragali, Cortex Phellodendri, semen coicis, Radix Glycyrrhizae and 1/2 recipe quantity is taken
Slag adds water to cook 1-3 times, 1-3 hours each, collecting decoction, filtering, takes medical fluid obtained by step 1) to merge concentration therewith, after cooling
Add ethyl alcohol standing 12 hours or more, is allowed to sufficiently precipitate；By the supernatant liquid filtering after alcohol precipitation, ethyl alcohol is recycled, is concentrated under reduced pressure into leaching
Cream, then setting in vacuum oven dry, pulverize, and obtain medicinal extract fine powder；
4) leech, centipede, the scorpio of another 1/2 amount are ground into fine powder or micropowders, with medicinal extract fine powder obtained by step 3),
The pharmaceutic adjuvants such as volatile oil betadex inclusion compound and starch obtained by step 2) mix by a certain percentage, and ethyl alcohol is added and soaks
Softwood is made in agent；Softwood is added in medicine refining machine, is refined 2-3 times, makes softwood softening uniformly, until hardness is suitble to shaping,
The qualified softwood of refining is added step-wise in pellet processing machine feed bin and starts to manufacture pellet, qualified pill is polished, shaping glazing, does
It is dry, select ball and coating, be finally packaged machine sealed package, pill be made.
Pharmacodynamics test example
1 train of thought Shutong granules of test example cause the influence of aseptic necrosis of femoral head to study dexamethasone
1 material and method
1.1 animal
Female New Zealand large ear rabbit, average weight (2.5 ± 0.16) kg.
1.2 drugs and reagent
Radionuclide imaging agent technetium 99-m- Medronate sodium (99mTc-MDP) is by the glad limited public affairs of section's medicine company in Shanghai
Department provides；Therapeutic agent technetium 99- Medronate sodium (99Tc-MDP) is provided by Chengdu cloud gram medicine company responsibility Co., Ltd:
Wherein A bottles are g/5mL/ bottles of 5.5 μ of 99Tc liquid, and B bottles of MDP are 5mg/ bottles；Dexamethasone sodium phosphate injection (DX) 5mg/1mL/ branch,
It is produced by Cisen Pharmaceutical Co., Ltd.；Train of thought Shutong granules are provided by Shandong Lunan Hou Pu pharmaceutical Co. Ltd.
1.3 detecting instrument equipment animal bone density analyzers (Dual-energy X-rays absorptionmetry LUNAR.DXP-L.USA)；Bone is raw
Object dynamics measurement (biomechanics of bone tester INSTRON-5543.USA)；Nucleic skeletal imaging and CT take the photograph piece (SPECT/CT, PR
ECEDENCE, U.S. Philips Corporation), use the general parallel aperture collimator of low energy.X ray photograph, pathology and biochemical instruments are normal
Advise equipment.
1.4 test method
1.4.1 the foundation of model
Female New Zealand experimental rabbit 41, be randomly divided into two groups: Normal group (9) and ANFH group (32) adapt to
Property feed 1 week, fasting.ANFH group is using intramuscular injection of dexamethasone sodium phosphate injection (DX) 3mg/kg induction production ANFH mould
Type, Normal group is with physiological saline 2mL intramuscular injection, and 2 times/weekly, continuous injection 8 weeks, whether every group take 7 identification modelings
Success, by random 4 groups of ANFH group, every group 7, is divided into model control group, 99Tc-MDP group, arteries and veins after determining ANFH modeling success
Network Shutong granules low dose group, train of thought Shutong granules high dose group, continue to DX3mg/kg intramuscular injection, are changed to 1 times/week,
Until experiment terminates.During the feeding process, model control group has 1 experimental rabbit when the 11st week because of diarrhea death.
1.4.2 medication
1. train of thought Shutong granules group: train of thought Shutong granules are low, high dose group gastric infusion dosage be respectively 6.25g/kg,
25.0g/kg.2. positive control drug group: giving 99Tc-MDP, 99Tc liquid 5mL in A bottles is injected in B bottles, after shaking up 1min, use
After normal saline dilution to 0.2mg/5mLkg, carries out ear vein and inject treatment, 1 times a week.
1.4.3 detection project
Pathology osteocyte, bone density, Bones morphology metering, biomechanics experiment, nucleic 99mTc-MDP skeletal imaging R
OI ratio (takes femoral head position and absorbs the ratio of more stable, the minimum position fourth coccygeal vertebra ROI of skeletal imaging agent) detection.
1.5 statistical method
Data are handled using SPSS16.0 statistical software.Experimental result is with mean and standard deviationForm
It indicates, group difference comparison is carried out using one-way analysis of variance, P < 0.05 indicates that difference has statistical significance.
2 experimental results
The observation of 2.1 ordinary circumstances
After treating 16 weeks, Normal group experimental rabbit hair color is smooth, eyes are bright, action is flexible；Model control group goes out
Existing apathetic, the tired sleeping, chaeta of chilly dries up, activity is slow；99Tc-MDP group chaeta is relatively withered, and spirit is not good enough, and activity is slightly slow
It is slow；Train of thought Shutong granules low dose group, chaeta is more smooth, and spirit is not good enough, and activity is still；Train of thought Shutong granules high dose group chaeta
Smooth, flexibly, eyes are bright for action.
2.2HE dyeing
After treatment 16 weeks, HE dyeing display: Normal group experimental rabbit bone trabecula queueing discipline, uniform, no bone tissue
Collapse state；The arrangement of model control group experimental rabbit bone trabecula is sparse, and there are obvious bone trabecula, sparse companion is broken, between bone trabecula
It is in obvious bone destruction's form in the presence of cavity and adipose tissue filling；99Tc-MDP group trabecular bone density is compared with model control group
It increased, bone trabecula phenomenon of rupture disappears；The significantly densification, thickening of train of thought Shutong granules low dose group bone trabecula form；
The bone tissue morphologic arrangement of train of thought Shutong granules high dose group femoral head is relatively regular, uniform, without obvious disorganization.
2.3 laboratory testings and other indexs
2.3.1 compared with model control group, each dosage group of train of thought Shutong granules is remarkably improved femoral head and lumbar vertebra is close
Degree and Bones morphology metering, femoral head and lumbar vertebrae biomechanics of bone significantly reduce nucleic skeletal imaging ROI value, and indices improve significantly,
Difference has statistical significance.Test result is shown in Table 1.
Influence result of the 1 train of thought Shutong granules of table to aseptic necrosis of femoral head
| Group | Bones morphology measures (%) | Bony nodule element images (%) |
| Normal group | 128.315±23.576 | 4.589±1.147 |
| Model control group | 65.532±19.572 | 7.579±1.514 |
| Positive controls | 71.981±27.524* | 6.879±1.245* |
| Train of thought Shutong granules low dosage | 91.258±25.654** | 6.104±1.014** |
| Train of thought Shutong granules high dose | 119.547±27.913** | 5.981±0.874** |
Compared with model control group, * p < 0.05, * * p < 0.01.
The clinical research of clinical test train of thought Shutong granules treatment aseptic necrosis of femoral head
1. clinical data
1.1 general information
In June, 2014~2015 year December, we are to 400 aseptic necrosis of femoral head patients, according to table of random number
Method is divided into treatment group and control group each 200.
Male 115, female 85 in treatment group；Age 30~75 years old, average (59.34 ± 10.23) year；The course of disease 5~15
Month, average (6.85 ± 2.51) a month；Pathogenesis: chronic alcoholism 47, prolonged application hormone 153.
Male 121, female 79 in control group；Age 29~73 years old, average (57.23 ± 11.21) year；The course of disease 3~15
Month, average (6.51 ± 3.01) a month；Pathogenesis: chronic alcoholism 51, prolonged application hormone 149.
Two groups of Genders, age differences are not statistically significant (P > 0.05), are comparable.
1.2 treatment method
Control group: to initial stage (1,2) type patient: strictly avoiding prudent, or do and make femoral head brill in synovium of joint resection
Hole treatment.To the 3 phases above patient (femoral head existing much sexually revise or the fragmentation that be recessed): by perform the operation by focal cleaning, do it is more
Vascular bundles and bone grafting operation.
Treatment group: to initial stage (1,2) type patient: strictly avoiding prudent, or do and make femoral head brill in synovium of joint resection
After the treatment of hole, train of thought Shutong granules are taken, 3 times a day, each 20g.To the 3 phases above patient, (femoral head is existing much to be sexually revised
Or recess fragmentation): after performing the operation focal cleaning, doing a plurality of vascular bundles and bone grafting operation, take train of thought Shutong granules, daily 3
It is secondary, each 20g.It is observed after being treated 9 weeks with above-mentioned therapy.
1.3 observation index and method
1.3.1 hip joint function
Progress Harris scoring before treatment and after treatment 9 weeks, 0~100 point of score value, the higher prompt hip joint of score value
Functional rehabilitation effect is better.
1.3.2 pain degree
VAS scoring is carried out before treatment and after treatment 9 weeks, 0~10 point of score value, score value is higher, and prompt pain is tighter
Weight.
1.3.3 curative effect is treated
Criterion of therapeutical effect is as follows:
Cure: clinical symptoms all disappear, and former femoral head shortcake sexually revises or fragmentation restores.Effective: clinical symptoms are obvious
Improve (pain relief, interior receipts outreach limitation of activity have improvement), x-ray photo femoral head shortcake sexually revises diminution or fuzzy.It is invalid: to face
Bed symptom and x-ray photo are not improved.
1.4 statistical method
Data select SPSS17.0 software to carry out statistical disposition.Measurement data is with mean ± standard deviationIt indicates, than
It is examined compared with using t；Enumeration data compares using x2It examines.
2. treatment results
2.1 hip joint functions and pain degree
After treatment, treatment group Harris scoring is apparently higher than control group (P < 0.01), and VA0S scoring is significantly lower than control group
(P<0.01)。
The pretherapy and post-treatment Harris scoring of 2 train of thought Shutong granules of table and VAS scoring are compared
Compared with the control group, P < 0.01 * P < 0.05, * *.
2.2 treatment curative effects
200 recoveries from illness 143 for the treatment of group account for 71.5%, and effective 30 account for 15%, and invalid 27 account for 13.5%, total effective rate
86.5%.Control group 200 recoveries from illness 70 account for 35%, and effective 56 account for 28%, and invalid 74 account for 37%, total effective rate 63%.
Two groups of comparing differences are statistically significant (P < 0.05), and treatment group is better than control group.
The recent total effective rate of train of thought Shutong granules treatment group is significantly higher than control group；Treatment group hip arthralgia VAS scoring
Substantially less than control group, Harris score obviously higher than control group.Train of thought Shutong granules treat aseptic necrosis of femoral head can
It is effectively improved Clinical symptom and sign, improves extremity motor function.
Specific embodiment
The present invention is further illustrated below by way of specific embodiment, but those skilled in the art should know, the implementation
Example is not limit the invention in any way.
1 train of thought Shutong granules agent of embodiment
Chinese traditional medicine composition group prescription:
Preparation method:
1) it takes honeysuckle, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, the Radix Paeoniae Alba of above-mentioned prescription amount to be placed in multi-function extractor and carries out water steaming
Steam distillation obtains the dregs of a decoction, medical fluid and volatile oil crude product；It will volatilize oily crude product redistillation, obtain refined volatile oil,
2) refined volatile oil obtained by step 1) is added into dehydrated alcohol, is uniformly mixed, obtains ethyl alcohol volatile oil solution, set closed appearance
Storage in device；
3) leech, centipede, the scorpio of the Radix Astragali of above-mentioned prescription amount, Cortex Phellodendri, semen coicis, Radix Glycyrrhizae and above-mentioned 1/2 recipe quantity are taken
And the dregs of a decoction obtained by step 1) add water to cook 2 times, the time is respectively 1.5 hours and 1 hour, and collecting decoction filters, takes step 1)
Gained medical fluid merges concentration therewith, and after cooling plus ethyl alcohol stands 12 hours or more, is allowed to sufficiently precipitate, by the supernatant after alcohol precipitation
Ethyl alcohol is recycled in filtering, is concentrated under reduced pressure into medicinal extract；
4) leech, centipede, the scorpio of remaining 1/2 amount are ground into fine powder, by medicinal extract obtained by fine powder, step 2) by certain ratio
Example mixes, and ethyl alcohol is added as wetting agent, softwood is made, and enters the drying of boiling type drying bed, sprays distillate, direct through normal process steps
Or pharmaceutically acceptable excipient is added, granule is made.
2 train of thought of embodiment, which is relaxed, leads to tablet
Chinese traditional medicine composition group prescription:
1) it takes honeysuckle, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, the Radix Paeoniae Alba of above-mentioned prescription amount to be placed in multi-function extractor and carries out water steaming
Steam distillation obtains the dregs of a decoction, medical fluid and volatile oil crude product；It will volatilize oily crude product redistillation, obtain refined volatile oil,
2) refined volatile oil obtained by step 1) is added into dehydrated alcohol, is uniformly mixed, obtains ethyl alcohol volatile oil solution, set closed appearance
Storage in device；
3) leech, centipede, the scorpio of the Radix Astragali of above-mentioned prescription amount, Cortex Phellodendri, semen coicis, Radix Glycyrrhizae and above-mentioned 1/2 recipe quantity are taken
And the dregs of a decoction obtained by step 1) add water to cook 1 time, the time 3 hours, decocting liquid filtering took medical fluid obtained by step 1) to merge therewith dense
Contracting, after cooling plus ethyl alcohol stands 12 hours or more, it is allowed to sufficiently precipitate, by the supernatant liquid filtering after alcohol precipitation, recycles ethyl alcohol, decompression
It is condensed into medicinal extract；
4) leech, centipede, the scorpio of remaining 1/2 amount are ground into fine powder, by medicinal extract obtained by fine powder, step 2) by certain ratio
Example mixes, and ethyl alcohol is added as wetting agent, softwood is made, and enters the drying of boiling type drying bed, sprays distillate, direct through normal process steps
Or pharmaceutically acceptable excipient is added, tablet is made.
3 train of thought of embodiment is relaxed dripping pills for dredging
Chinese traditional medicine composition group prescription:
1) it takes above-mentioned prescription amount honeysuckle, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba to be placed in multi-function extractor and carries out water vapour
Distillation, obtains the dregs of a decoction, medical fluid and volatile oil crude product；It will volatilize oily crude product redistillation, obtain refined volatile oil；
2) refined volatile oil obtained by step 1) is added into dehydrated alcohol, is uniformly mixed, obtains ethyl alcohol volatile oil solution, set closed appearance
Storage in device；
3) leech, centipede, scorpio and the step of above-mentioned prescription amount Radix Astragali, Cortex Phellodendri, semen coicis, Radix Glycyrrhizae and 1/2 recipe quantity are taken
Rapid 1) the gained dregs of a decoction add water to cook 2 times, and the time is respectively 1.5 hours and 1 hour, and collecting decoction filters, and take medicine obtained by step 1)
Liquid merges concentration therewith, and after cooling plus ethyl alcohol stands 12 hours or more, is allowed to sufficiently precipitate, by the supernatant liquid filtering after alcohol precipitation,
Ethyl alcohol is recycled, is concentrated under reduced pressure into medicinal extract；
4) leech, centipede, the scorpio of another 1/2 recipe quantity are ground into fine powder, by medicinal extract obtained by fine powder, step 2) and sugar
The pharmaceutic adjuvants such as powder and dextrin mix by a certain percentage, ethyl alcohol are added as wetting agent, softwood is made, and enter the drying of boiling type drying bed,
Distillate is sprayed, through normal process steps directly or pharmaceutically acceptable excipient is added dripping pill is made.
4 train of thought of embodiment is relaxed Tongru preparation for promoting lactation
Chinese traditional medicine composition group prescription:
Directly or pharmaceutically acceptable excipient is added with the embodiment of the present invention 1, through normal process steps in other preparation methods
Emulsion is made.
5 train of thought of embodiment, which is relaxed, leads to masticatory
Chinese traditional medicine composition group prescription:
Directly or pharmaceutically acceptable excipient is added with the embodiment of the present invention 1, through normal process steps in other preparation methods
Masticatory is made.
6 train of thought of embodiment, which is relaxed, leads to pill
Chinese traditional medicine composition group prescription:
1) extracting honeysuckle, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba, which are placed in multi-function extractor, carries out steam distillation, obtains medicine
Slag, medical fluid and volatile oil crude product；It will volatilize oily crude product redistillation, obtain refined volatile oil；
2) refined volatile oil obtained by step 1) is prepared into volatile oil betadex inclusion compound, sets storage in closed container；
3) medicine obtained by leech, centipede, scorpio and the step 1) of Radix Astragali, Cortex Phellodendri, semen coicis, Radix Glycyrrhizae and 1/2 recipe quantity is taken
Slag adds water to cook 3 times, and 1 hour every time, collecting decoction, filtering took medical fluid obtained by step 1) to merge concentration therewith, adds second after cooling
It alcohol standing 12 hours or more, is allowed to sufficiently precipitate；By the supernatant liquid filtering after alcohol precipitation, ethyl alcohol is recycled, is concentrated under reduced pressure at medicinal extract, so
It dry, pulverize in postposition vacuum oven, obtain medicinal extract fine powder；
4) leech, centipede, the scorpio of another 1/2 amount are ground into micropowders, with medicinal extract fine powder, step 2) obtained by step 3)
The pharmaceutic adjuvants such as gained volatile oil betadex inclusion compound and starch mix, and ethyl alcohol are added as wetting agent, softwood is made；It will be soft
Material is added in medicine refining machine, is refined 3 times, makes softwood softening uniformly, until hardness is suitble to shaping, will the qualified softwood of refining by
Step, which is added in pellet processing machine feed bin, to be started to manufacture pellet, and qualified pill is polished, shaping glazing, drying, selects ball and coating, finally
It is packaged machine sealed package, pill is made.
7 train of thought of embodiment, which is relaxed, leads to pill
Chinese traditional medicine composition group prescription:
Preparation method is the same as the embodiment of the present invention 6.
8 train of thought of embodiment, which is relaxed, leads to oral liquid formulations
Preparation method directly or is added pharmaceutically acceptable excipient and is made with the embodiment of the present invention 1, through normal process steps
Oral solution.
9 train of thought Shutong capsule preparation of embodiment
Preparation method directly or is added pharmaceutically acceptable excipient and is made with the embodiment of the present invention 1, through normal process steps
Capsule.
10 train of thought Shutong granules agent of embodiment
Prescription is the same as the embodiment of the present invention 2.
1) after being cleaned by three kinds of leech of 1/2 recipe quantity, centipede, scorpio animal drugs, wash, sterilize, be dried, benefit
Micronizer is pulverized, and makes Ultramicro-powder average grain diameter less than 10 μm；
2) extracting honeysuckle, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba, which are placed in multi-function extractor, carries out steam distillation, obtains medicine
Slag, medical fluid and volatile oil crude product；It will volatilize oily crude product redistillation, obtain refined volatile oil, add dehydrated alcohol, be uniformly mixed, obtain second
Alcohol volatile oil solution sets storage in closed container；
3) dregs of a decoction obtained by step 2) add water to cook extraction together with Radix Astragali, Cortex Phellodendri, semen coicis, Radix Glycyrrhizae, after Aqueous extracts filtering
Concentrated plus ethyl alcohol turns molten essence and mentions, is condensed into the water extracted immersing paste again；
4) by the water extracted immersing paste and appropriate granulation liquid obtained by remaining 1/2 recipe quantity leech, centipede, Scorpio superfine powder and step 3)
Granulation is mixed, dry, whole grain sprays into ethyl alcohol volatile oil solution obtained by step 2), seals and wraps through particles packing machine after mixing
Dress, is made particle.
11 train of thought Shutong granules agent of embodiment
Prescription is the same as the embodiment of the present invention 4.
1) after being cleaned by three kinds of leech, centipede, scorpio animal drugs, wash, sterilize, be dried, surpassed using preferred
Crushing of Ultrafine unit is pulverized, and makes medicinal powder average grain diameter less than 75 μm；
2) extracting honeysuckle, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba, which are placed in multi-function extractor, carries out steam distillation, obtains medicine
Slag, medical fluid and volatile oil crude product；It will volatilize oily crude product redistillation, obtain refined volatile oil, add dehydrated alcohol, be uniformly mixed, obtain second
Alcohol volatile oil solution sets storage in closed container；
3) the step 2) dregs of a decoction add water to cook extraction together with Radix Astragali, Cortex Phellodendri, semen coicis, Radix Glycyrrhizae, through dense after Aqueous extracts filtering
Contracting plus ethyl alcohol turn molten essence and mention, are condensed into the water extracted immersing paste again；
4) remaining 1/2 recipe quantity leech, centipede, Scorpio superfine powder are first stirred again with the water extracted immersing paste obtained by step 3)
Appropriate granulation liquid is added, granulation is mixed, dry, whole grain sprays into ethyl alcohol volatile oil solution obtained by step 2), after mixing through
Grain packing machine sealed package, is made particle.
12 train of thought Shutong granules agent of embodiment
Prescription is the same as the embodiment of the present invention 5.
1) after being cleaned by three kinds of leech, centipede, scorpio animal drugs, wash, sterilize, be dried, surpassed using preferred
Crushing of Ultrafine unit is pulverized, and makes medicinal powder average grain diameter less than 55 μm；
2) by honeysuckle, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba elder generation extracting in water volatile oil, the dregs of a decoction, medical fluid and volatile oil are obtained；
3) the step 2) dregs of a decoction add water to cook extraction together with Radix Astragali, Cortex Phellodendri, semen coicis, Radix Glycyrrhizae, through dense after Aqueous extracts filtering
Contracting plus ethyl alcohol turn molten essence and mention, are condensed into the water extracted immersing paste again；
4) by the water extracted immersing paste obtained by remaining 1/2 recipe quantity leech, centipede, Scorpio superfine powder flour and step 3) through conventional dry
Granulation is mixed in the worth Aqueous extracts extract dry powder of drying process and appropriate granulation liquid, dry, and whole grain is sprayed into and waved obtained by step 2)
Granule is made through particles packing machine sealed package after mixing in hair oil.
13 train of thought Shutong granules agent of embodiment
Prescription is the same as the embodiment of the present invention 5.
1) after being cleaned by three kinds of leech, centipede, scorpio animal drugs, wash, sterilize, be dried, surpassed using preferred
Crushing of Ultrafine unit is pulverized, and makes medicinal powder average grain diameter less than 28 μm；
2), 3), 4) with embodiment 10.
14 train of thought Shutong granules agent of embodiment
Prescription is the same as the embodiment of the present invention 5.
1) after being cleaned by three kinds of leech, centipede, scorpio animal drugs, wash, sterilize, be dried, surpassed using preferred
Crushing of Ultrafine unit is pulverized, and makes medicinal powder average grain diameter less than 55 μm；
2) extracting honeysuckle, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba, which are placed in multi-function extractor, carries out steam distillation, obtains medicine
Slag, medical fluid and volatile oil crude product；It will volatilize oily crude product redistillation, obtain refined volatile oil, add dehydrated alcohol, be uniformly mixed, obtain second
Alcohol volatile oil solution sets storage in closed container；
3) the step 2) dregs of a decoction add water to cook extraction together with Radix Astragali, Cortex Phellodendri, semen coicis, Radix Glycyrrhizae, through dense after Aqueous extracts filtering
Contracting plus ethyl alcohol turn molten essence and mention, are condensed into the water extracted immersing paste again；
4) remaining 1/2 recipe quantity leech, centipede, Scorpio superfine powder are first stirred again with the water extracted immersing paste obtained by step 3)
Appropriate granulation liquid is added, granulation is mixed, dry, whole grain sprays into ethyl alcohol volatile oil solution obtained by step 2), after mixing through
Grain packing machine sealed package, is made particle.
15 train of thought Shutong granules agent of embodiment
Prescription is the same as the embodiment of the present invention 9.
1) after being cleaned by three kinds of leech, centipede, scorpio animal drugs, wash, sterilize, be dried, surpassed using preferred
Crushing of Ultrafine unit is pulverized, and makes medicinal powder average grain diameter less than 75 μm；
2), 3), 4) with embodiment 14.
16 train of thought Shutong granules agent of embodiment
Prescription is the same as the embodiment of the present invention 7.
1) after being cleaned by three kinds of leech, centipede, scorpio animal drugs, wash, sterilize, be dried, surpassed using preferred
Crushing of Ultrafine unit is pulverized, and makes medicinal powder average grain diameter less than 30 μm；
2), 3), 4) with embodiment 14.
Claims (9)
- It is prepared as raw medicinal material 1. a kind of using Radix Astragali, honeysuckle, Cortex Phellodendri, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba and semen coicis Purposes of the Chinese medicine composition in preparation treatment aseptic necrosis of femoral head drug.
- 2. Chinese medicine composition according to claim 1, which is characterized in that the aseptic necrosis of femoral head is Alcoholic stock Head necrosis or steroid femur head necrosis.
- 3. Chinese medicine composition according to claim 1, which is characterized in that the Radix Astragali, honeysuckle, Cortex Phellodendri, rhizoma atractylodis, profound Ginseng, Radix Angelicae Sinensis, Radix Paeoniae Alba and semen coicis parts by weight are as follows:Radix Astragali 300-700 honeysuckle 300-700 Cortex Phellodendri 100-400Rhizoma atractylodis 100-400 radix scrophulariae 300-700 Radix Angelicae Sinensis 100-400Radix Paeoniae Alba 100-400 semen coicis 300-700.
- 4. Chinese medicine composition according to claim 3, which is characterized in that also contain following raw materials in the Chinese medicine composition Medicinal material: centipede, scorpio, leech and Radix Glycyrrhizae, preferred weight part are as follows: centipede 10-40, scorpio 50-100, leech 180-280, Radix Glycyrrhizae 50-100。
- 5. Chinese medicine composition according to claim 4, which is characterized in that the weight of each bulk pharmaceutical chemicals in the Chinese medicine composition Part are as follows:One of it is preferred that, the parts by weight of each bulk pharmaceutical chemicals in the Chinese medicine composition are as follows:It is preferred that two, the parts by weight of each bulk pharmaceutical chemicals in the Chinese medicine composition are as follows:
- 6. Chinese medicine composition according to any one of claims 1-5, which is characterized in that the Chinese medicine composition is oral Pharmaceutical preparation, it is preferable that the Chinese medicine composition oral drug preparation be its pill, granule, capsule, tablet, oral solution, One or more of masticatory, dripping pill and emulsion.
- 7. a kind of prepare the method such as Chinese medicine composition of any of claims 1-6, which is characterized in that including as follows Step:1) extracting honeysuckle, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, Radix Paeoniae Alba are placed in distillation in extractor, obtain the dregs of a decoction, medical fluid and volatile oil；2) volatile oil obtained by step 1) is added into dehydrated alcohol, is uniformly mixed, obtains ethyl alcohol volatile oil solution；3) Radix Astragali, Cortex Phellodendri, semen coicis, Radix Glycyrrhizae and 1/2 recipe quantity leech, centipede, scorpio and step 1) the gained dregs of a decoction are taken, water is added It decocts, filters to obtain decoction liquor, decoction liquor merges concentration, alcohol precipitation after concentrate is cooling with medical fluid obtained by step 1)；After alcohol precipitation Supernatant liquid filtering recycles ethyl alcohol, is concentrated under reduced pressure into medicinal extract；4) leech, centipede, the scorpio of remaining 1/2 recipe quantity are crushed into obtain medicinal powder, is mixed with medicinal extract obtained by step 2), through conventional work Sequence is directly or clinically-acceptable dosage form is made in the pharmaceutically acceptable excipient of addition.
- 8. method as described in claim 7, which is characterized in that volatile oil described in step 1) is prepared into his ring of volatile oil times Cyclodextrin inclusion compound.
- 9. method as described in claim 7, which is characterized in that the step 3) leech, centipede, scorpio through pulverizing, Preferably, gained Ultramicro-powder average grain diameter is less than 75 μm.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021042275A1 (en) * | 2019-09-03 | 2021-03-11 | 鲁南制药集团股份有限公司 | Traditional chinese medicine composition for treating osteoarthritis |
| WO2021042276A1 (en) * | 2019-09-03 | 2021-03-11 | 鲁南制药集团股份有限公司 | Combination drug for treating osteoarthritis |
| WO2021042274A1 (en) * | 2019-09-03 | 2021-03-11 | 鲁南制药集团股份有限公司 | Traditional chinese and western medicine composition for treating osteoarthritis |
| WO2021051261A1 (en) * | 2019-09-17 | 2021-03-25 | 鲁南制药集团股份有限公司 | Novel use of chinese medicine composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1425448A (en) * | 2002-08-07 | 2003-06-25 | 鲁南制药股份有限公司 | Medicine for curing thrombotic phlebitis |
| CN103933410A (en) * | 2013-01-21 | 2014-07-23 | 鲁南制药集团股份有限公司 | Medicinal use and preparation method of traditional Chinese medicine composition |
-
2017
- 2017-10-31 CN CN201711042464.9A patent/CN109718341A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1425448A (en) * | 2002-08-07 | 2003-06-25 | 鲁南制药股份有限公司 | Medicine for curing thrombotic phlebitis |
| CN103933410A (en) * | 2013-01-21 | 2014-07-23 | 鲁南制药集团股份有限公司 | Medicinal use and preparation method of traditional Chinese medicine composition |
Non-Patent Citations (1)
| Title |
|---|
| 郝秋彦等: "经皮髓芯减压联合介入及中成药治疗股骨头无菌坏死研究", 《滨州医学院学报》 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021042275A1 (en) * | 2019-09-03 | 2021-03-11 | 鲁南制药集团股份有限公司 | Traditional chinese medicine composition for treating osteoarthritis |
| WO2021042276A1 (en) * | 2019-09-03 | 2021-03-11 | 鲁南制药集团股份有限公司 | Combination drug for treating osteoarthritis |
| WO2021042274A1 (en) * | 2019-09-03 | 2021-03-11 | 鲁南制药集团股份有限公司 | Traditional chinese and western medicine composition for treating osteoarthritis |
| CN114340650A (en) * | 2019-09-03 | 2022-04-12 | 鲁南制药集团股份有限公司 | Combined medicine for treating osteoarthritis |
| CN114375196A (en) * | 2019-09-03 | 2022-04-19 | 鲁南制药集团股份有限公司 | Traditional Chinese medicine composition for treating osteoarthritis |
| CN114667156A (en) * | 2019-09-03 | 2022-06-24 | 鲁南制药集团股份有限公司 | A Chinese and western medicinal composition for treating osteoarthritis |
| WO2021051261A1 (en) * | 2019-09-17 | 2021-03-25 | 鲁南制药集团股份有限公司 | Novel use of chinese medicine composition |
| CN114390927A (en) * | 2019-09-17 | 2022-04-22 | 鲁南制药集团股份有限公司 | New application of traditional Chinese medicine composition |
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