CN109718312A - A kind of drug and preparation method thereof of Chinese medicine keritherapy treatment cancer pain - Google Patents

Abstract

The invention discloses a kind of drug and preparation method thereof of Chinese medicine keritherapy treatment cancer pain, the drug is mainly made of naze, arisacma consanguineum schott, Radix Aconiti and centipede.The drug can be used for treating cancer pain in Chinese medicine keritherapy, have effects that Wen Yanghua disease, promoting blood circulation.Suitable for negative subcutaneous ulcer, streamer, subcutaneous nodule, a kind of disease caused by venereal disease, it is swollen have a pain firmly, the various tumours of various unknown mass and doctor trained in Western medicine diagnosis meet above-mentioned shower.Significant in efficacy, safety is without side-effects.

Description

A kind of drug and preparation method thereof of Chinese medicine keritherapy treatment cancer pain

Technical field

The present invention relates to a kind of drugs and preparation method thereof of Chinese medicine keritherapy treatment cancer pain, belong to the neck of drug technology Domain.

Technical background

Cancer pain is one of most common symptom of malignant tumor patient, counts at least 5,000,000 cancers daily according to WHO and suffers from Person is in the torment for suffering from pain.Newly it is diagnosed as in the patient of malignant tumour that there are about 1/4 with pain, there are about 1/ in therapeutic process 3 patients are with pain caused by cancer, and progressive stage about 3/4 is with pain.In addition, pain is one of the symptom that patient most fears, it is difficult to alleviate Pain symptom often result in discomfort, and greatly affected the daily routines of patient, self-care ability, affective activity, serious Influence patient and exchanging between family members and friend, patients ' life quality degradation.

Pain caused by cancer is as in widespread attention an important factor for influencing effective antitumor plan progress, influence life quality.For Patient's pain, enhancing cancer patient's autoimmunity mitigated and controlled, the quality of life and quality of life of cancer patient, mesh improved The method of preceding common analgesic is injecting anesthetic drug, though these medicines energy reduction of patient pain, patient are used for a long time and are also easy to produce Dependence, and patient is also easy addicted, as the progress of the state of an illness also needs escalated dose and shortens administration time, therefore side effect is big.

Wax therapy is that a kind of wax of utilization heating is applied in affected part, or affected part is immersed the physical therapy method in wax liquor.With elimination Swelling deepens warm-heat effect, adhesion of loosening, and softens the mechanism of scar.Modern wax therapy technology is that Chinese medicine is organic with wax therapy Ground is combined together, and can reinforce permeability of cell membrane, mitigates tissue edema, is generated soft mechanical pressure effect, is kept skin soft Soft and high resilience can improve skin-nourishing, accelerate the growth of epithelium, be conducive to the healing of surface of a wound ulcer and fracture, also have Ease pain spasmolysis.

Therefore, the pharmaceutical formulation for inventing a kind of Chinese medicine keritherapy treatment cancer pain is of great significance.

Summary of the invention:

The object of the present invention is to provide a kind of drugs and preparation method thereof of Chinese medicine keritherapy treatment cancer pain.The drug It can be used for treating cancer pain in Chinese medicine keritherapy, have effects that Wen Yanghua disease, promoting blood circulation.Suitable for negative subcutaneous ulcer, streamer, phlegm Core, a kind of disease caused by venereal disease, it is swollen have a pain firmly, the various tumours of various unknown mass and doctor trained in Western medicine diagnosis meet above-mentioned shower.It is significant in efficacy, safety It is without side-effects.

In order to solve the above technical problems, the present invention is implemented with the following technical solutions:

A kind of drug of Chinese medicine keritherapy treatment cancer pain, calculates by weight, mainly by 3-9 parts of naze, 5-15 parts of arisacma consanguineum schott, 5-15 parts and centipede 1-3 parts of Radix Aconiti are made.

It in the drug of Chinese medicine keritherapy treatment cancer pain above-mentioned, calculates by weight, mainly by 5-7 parts of naze, raw south 8-12 parts of star, 8-12 parts of Radix Aconiti and 1.5-2.5 parts of centipede are made.

In the drug of Chinese medicine keritherapy treatment cancer pain above-mentioned, calculate by weight, mainly by 6 parts of naze, arisacma consanguineum schott 10 parts, 10 parts of Radix Aconiti and 2 parts of centipede are made.

A kind of production method of the drug of Chinese medicine keritherapy treatment cancer pain above-mentioned, takes said medicine, can add auxiliary material, Auxiliary material can also be not added, external preparation is made.

In the production method of the drug of Chinese medicine keritherapy treatment cancer pain above-mentioned, the external preparation is wax therapy ointment.

In the production method of the drug of Chinese medicine keritherapy treatment cancer pain above-mentioned, the wax therapy ointment is prepared: taking The above medicinal material is that 1:20 is soaked in water for 24 hours by the weight ratio of medicinal material and water, abandons filtrate, the solid dregs of a decoction and edible sesame oil are in 145- 155 DEG C of holding azeotropic 30min stand cooling supernatant；It is that 1:2 weighs 80 DEG C of melts of beeswax by the weight ratio of edible sesame oil and wax Change, be slowly added to oily phase supernatant, stir evenly 20min, cooling and solidifying to get.

The production method of the drug of Chinese medicine keritherapy treatment cancer pain above-mentioned, the weight of the solid dregs of a decoction and edible sesame oil Amount is than being 1:2.

Drug of the present invention is mainly made by naze, arisacma consanguineum schott, Radix Aconiti and centipede.Wherein, naze is pangolin The scale and shell of section's animal pangolin, it is salty, it is cool, it is slightly cold.Return liver, stomach meridian.The major functions: newborn under promoting menstruation, detumescence and apocenosis searches wind and removing obstruction in channels.For Amenorrhea and stranguria, alactation, carbuncle sore tumefacting virus, arthralgia, numbness contracture.Arisacma consanguineum schott is a kind of Chinese medicine, is derived from rhizoma arisaematis (day south Star section plant rhizoma arisaematis Arisaema erubescens (Wall.) Schott., Arisaema heterophyllum Blume Arisaema Heterophyllum Blume or arisaema amurense Maxim Arisaema amurense Maxim.) rhizome.Pharmacological property: it is bitter, pungent, Temperature；Effect: eliminating dampness and eliminating phlegm, expelling wind and relieving convulsion, mass dissipating and swelling eliminating.For stupid productive cough, anemophlegmatic vertigo, heap soil or fertilizer over and around the roots of apoplexy phlegm, facial paralysis, half Body is unsuccessful, epilepsy, infantile convulsion, tetanus.Raw controlling outward carbuncle swells, snakebite and bugbite.Radix Aconiti, English name Aconite Root are hair Female root of gelsemium section plant Cattell rhizome of Chinese monkshood AconitumcarmichaeliDebx..[major function] dispelling wind and eliminating dampness, antalgic.With Have a pain in wind-cold-dampness arthralgia, arthralgia, trusted subordinate's crymodynia, cold hernia.For treating the illnesss such as wind-cold-dampness arthralgia, arthralgia.General big gun It is taken orally after system.The external application of Radix Aconiti tincture can stimulate skin, then generate feeling of numbness, therefore be used as the analgesia of certain neuralgias and rheumatism outside Agent.[meridian distribution of property and flavor] is pungent, bitter, heat;It is very toxic.Return heart, liver,kidney,spleen warp.Centipede (Chilopoda) is terrestrial arthropod, this Body can enter medicinal, and [meridian distribution of property and flavor] is acrid in flavour and warm in nature.Return liver warp.[major function] relieve the wind syndrome antispastic, dispersing pathogen accumulation are removed obstruction in channels to relieve pain.For Child convulsion, spasm of twitching, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, sore, scrofula, venomous snake bite.

Simple pain is mostly the simultaneous phenomenon of disease, and the duration is shorter, and the state of an illness is simpler, and treatment must go out from disease itself Hair carries out Coryza Treated by Syndrome Differentiation；And cancer pain is existed as an independent disease, the state of an illness is more complex, there is Acute Pain and slow Property pain point, early stage disease development, mid-term based on real pain, advanced stage then based on simulataneous insufficiency and excessive, with simple pain phase Than, pain caused by cancer mostly because of cold solidifying, blood stasis, the obstruction of the circulation of vital energy, phlegm is turbid, the deficiency of vital energy, negative blood dystrophy, yang-energy virtual loss or the not general rule pain such as yin-yang deficiency, no Rong Ze pain has different development processes because it is as independent disease, due to the difference of individual difference and disease progression, uses Different therapeutic rules, but because of the particularity of tumor patient, clinic is mostly using strengthening vital QI to eliminate pathogenic factors as fundamentum.In addition, cancer pain For causing the cause of disease of cancer pain to be treated.The Etiological of pain caused by cancer pain is cancer itself, complication etc..For cancer Patient gives anticancer therapy, such as operation, radiotherapy or chemotherapy, may release cancer pain.And it is most of chronic non- The origin cause of formation of cancer pain be it is multifactor, be related to periphery and (or) central sensitization mechanism, it is therefore desirable to multi-mode treatment.

Therefore, compared to the preparation for the drug for treating common cancer pain, a kind of skill of drug for treating cancer pain is prepared Art difficulty is much higher, and for the technical solution for obtaining the application, the present inventor need to carry out a series of in conjunction with the characteristic of cancer pain Experimental study and grope, makes the creative labor.

Connection between component part each in drug matching, is visually defined as the relationship of monarch.The monarch and his subjects' assistant The presence for making certain a part is premised on the presence of other parts.Connection between monarch can make primary-slave relation, It is also possible to conspiracy relation, restricting relation etc..The monarch relationship of drug matching defines the orderly of each taste Chinese medicine arrangement Property.The existing specific grade of relationship between monarch, and have apparent level.For pharmacokinetics angle, minister, Absorption, distribution, the elimination helped, make the effect components in medicine that may influence effective component in monarch drug in a prescription.In addition, the curative effect of drug is not only Related with the chemical structure of drug and dosage, the physicochemical property of drug itself is different, also will affect the physiological disposition of drug, especially It is absorption process, to influence the curative effect of drug.The above analysis, drug plus-minus, dosage number, dosage form in Chinese medicine composition Replacement can all make its function that different variations occur.Therefore, in Chinese medicine composition drug type and its dosage, need to follow monarch, Under minister, the principle helped, made, the state of an illness, constitution, age, gender and season, weather and living habit of patient etc. are combined, It need to give flexibility sanction according to the concrete condition of patient, plus-minus uses, and accomplishes " Shi Qifa is without its side of mud ".

Motherland's medicine thinks: " product person, negative gas, therefore sink and lie prostrate." " pain person, cold air is mostly." yin subcutaneous ulcer, streamer, subcutaneous nodule, cross Xuan, the forming mostly cold sensation of the genitalia cult poison for gathering lump gas stay to crouch and do not go, qi and blood is not smooth, phlegm resistance, and the then vim and vigour stasis of blood of accumulating in the course of time is stagnant, arteries and veins Network is obstructed.Therefore it is monarch drug in a prescription that we, which select naze, and wind and removing obstruction in channels is searched in promoting menstruation detumescence；Arisacma consanguineum schott, Radix Aconiti are ministerial drug altogether, and dissipating bind disappears Swollen, Wen Yanghua disease；It helps with centipede activating microcirculation and removing stasis medicinal, remove obstruction in channels to relieve pain.Full cream drug is high strong, and penetration is strong, is suitble to external application, plays Wen Yang altogether The function changing disease, removing obstruction in channels to relieve pain.It can be used for treating cancer pain.

Compared with prior art, the drug can be used for treating cancer pain in Chinese medicine keritherapy, have Wen Yanghua disease, promoting blood circulation The effect of dissolving stasis.Suitable for negative subcutaneous ulcer, streamer, subcutaneous nodule, a kind of disease caused by venereal disease, it is swollen have a pain firmly, various unknown mass and the various of doctor trained in Western medicine diagnosis swell Tumor meets above-mentioned shower.Significant in efficacy, safety is without side-effects.

Treat example

1, patient Chen Meishan；Gender: female；Age: 76 years old；Department: oncology；Time: on 01 08th, 2018；

Because dizzy shortness of breath is gone to a doctor in the first affiliated hospital of Guiyang Medical College before patient 1 year, at that time without fever with aversion to cold, cough is spat blood, The diseases such as syntexis are gone to a doctor in our hospital's row chest CT: inferior lobe of right lung multiple nodules, and malignant change may, it is proposed that aspiration biopsy, Yu Gui Positive the first affiliated hospital, medical college row PET/CT: bottom right lung multiple nodules, metabolism is active, tendency primary pulmonary Ca and surrounding intrapulmonary Transfer；Lymph node metabolism in the area 9R is increased, and is shifted wait arrange；Right lung door and vertical diaphragm part calcification of lymph node；Rib, the right side before left side the 5th Side ilium, T12 centrum, the left side L4 transverse process local metabolic increase, tendency transfer；Transverse process pathologic fracture on the left of L4.For into one Step treatment is gone to a doctor in Guizhou Province People's Hospital, it is proposed that the clear pathologic feature of patient's pathological biopsy and chemicotherapy of further performing the operation, but Family members consider that patient's advanced age is not resistant to indicate refusal, give patient's improvement discharge after supportive treatment to the ill, rear patient is repeatedly because of the right side Side ilium pain up to 6 points of NRS scoring, during which gives drug of the present invention in the hospitalization of the first affiliated hospital of Guiyang Medical College (being made by embodiment 1) carries out Chinese medicine keritherapy, and NRS scores 1 point after treatment 2 weeks, pain relief patient discharge.

2, patient Bi Baoni；Gender: female；Age: 56 years old；Department: oncology；Time: on 06 03rd, 2018, patient 3 Because finding left newborn mass, about egg size, no skin ulceration and nipple discharge without obvious inducement before year " it goes to a doctor and is cured in Chongqing southwest Institute, the prompt of row pathological biopsy: being shown in that cancer infiltrates in (left cream) infiltrating cancer (left armpit) fibr tissue, excludes row 8 after chemotherapy taboo Secondary chemotherapy (concrete scheme and dosage are unknown), the left modified radical mastectomy of row after end of chemotherapy, smoothly, postoperative disease is examined back for operation Show: (left breast cancer) invasive lobular carcinoma is with lymphatic metastasis 49/49, immunohistochemical staining: CKH(+), ER(+) 60%, PR (+) 30%, Her-2 (-), E-cad(+), Ki67 positive cell number 10%, P63(-), CK5/6 (-), P120(+).It is postoperative to give radiotherapy 28 times (concrete scheme is unknown), hereafter patient's periodic review, does not tell special discomfort.Patient feels shoulder back pain, Yu Chong before September It celebrates southwest hospital row CT and checks prompt: liver, Bone tumour (having no report), changed the place of examination then in tumour hospital, Peking University, row PET/CT shows: lymphatic metastasis is possible between Mammary cancer liver, Bone tumour and right lung door, hepatic hilar region, head of pancreas and door vena cave, C1D1 cycle T X scheme chemotherapy (albumin taxol 260mg/m2 is given on October 10th, 2017 after excluding chemotherapy taboo 200mg d1, d8, capecitabine 1g/m2 1.5gBid d1-d14 Q12d), 3 degree are reduced because leucocyte occurs in patient, in Property 4 degree of Granulocytopenia, brothers react 2 degree, in C3D1 period deactivated capecitabine, in 01 month 2018 26 Day row C5D8 period list medicine T scheme chemotherapy (albumin taxol 260mg/m2 200mg d1, d8, Q12d), end of chemotherapy After change and give fulvestrant maintenance therapy (500mg d1, d14 the first month, thereafter 500mg d1 Q28d), and monthly give zoledronic acid Anti- Bone tumour treatment.Patient feels left shoulder back and double knee joint pain without obvious inducement again before 1 week, after taking anodyne certainly, suffers from Person's Pain management is bad, and modern patient is to seek further systematic treating, goes to a doctor in the first affiliated hospital of Guiyang Medical College.It is existing symptoms include: Apathetic, left shoulder back and double knee joint pain, pain are in dull pain, and limb is soft out of strength, receive poor, the no fever with aversion to cold of not good enough dormancy, nothing Nausea and vomiting and abdominal distension diarrhea.NRS scores 7 points, during which gives drug of the present invention (being made by embodiment 1) and carries out Chinese medicine keritherapy After a week, spirit and pain are clearly better, and patient NRS scores 2 points after continual cure 1 week, discharge.

3, patient Liu Jian；Gender: male；Age: 58 years old；Department: oncology time: on 08 21st, 2018；Diagnosing liver cancer And 2+ after Lung metastases interventional procedure, it occurs together within lower abdominal pain 1 day 5+ hours hot.There is lower abdomen without obvious inducement in patient before 1 day Portion is in great pain, and analgesic effect is bad after voluntarily taking oxycodone hydrochloride sustained release tablets, and during which pain gradually aggravates, and goes out before 5 hours It now generates heat, 38 DEG C of body temperature, goes to a doctor for further therapy of combing traditional Chinese and Western medicine in the first affiliated hospital of Guiyang Medical College, outpatient service is with " liver Product " is admitted to hospital.It is existing symptoms include: abdomen slightly bulge, lower abdomen distending pain, pain aggravates when changing position, fever, the diseases such as no cough, runny nose, Limb is soft out of strength, receive can, sleep it is poor, oliguria, stool is difficult to resolve.NRS scores 4 points.Period gives drug of the present invention and (carries out by embodiment 1 Production) carry out Chinese medicine keritherapy after a week, NRS scores 1 point, and patient is discharged from hospitals upon recovery after pain is clearly better.

4, patient Li Antian；Gender: male；Age: 66 years old；Department: oncology；Time: on 06 27th, 2018；Main suit: It was found that the left lung occupy-place 1+ month, the multiple transfer of diagnosis lower-left adenocarcinoma of lung 1 week.Patient sent out without aversion to cold at that time because of flank pain before January Heat, the diseases such as frequent micturition urodynia hematuria, goes to a doctor in " Xifeng county people's hospital ", row pelvic MRI is shown: considering Study of Sacral Chordo-ma；Bilateral Ilium, ischium change or transfer, gives after " ammonia phenol Dihydrocodeine piece " analgesia without being clearly better, it is proposed that patient transfers from one hospital to another treatment.For Further treatment is gone to a doctor shows in " Guizhou affiliated hospital, medical university " row sacrum and coccyx MRI: 1, lumbosacral spine, bilateral ilium frequently-occurring disease Become, abnormal signal in surrounding soft tissue meets sacrum and coccyx, bilateral ilium metastatic tumor and surrounding soft tissue and invaded；2, waist sacrum vertebra Matter is loose.Chest CT is shown: 1, considers lower-left lung peripheral lung Ca and double intrapulmonary, vertical phrenic lymph nodes shifts, multiple turn of rib cage, thoracic vertebrae It moves；2, Liver metastases possibility is big.It is recommended that patient's row pathologic finding, with clear property, family members indicate to refuse, after symptomatic treatment Leave hospital, Chinese medicine treatment (specifically unknown) is voluntarily taken outside institute.Patient feels waist before 10 days, pain of buttock aggravates, and ache influence is suffered from Person's sleep is gone to a doctor with double lower limb feeling of numbness in our hospital's orthopaedics, suggests giving " oxycodone hydrochloride sustained release tablets 10mg after asking my section's consultation of doctors Poq12h " analgesic, parallel sacrococcygeal region biopsy of tumors, pathological replacement prompt: " sacrococcygeal region " gland cancer is supported in conjunction with ImmunohistochemistryResults Results Lung source, therefore patient is further treatment, is gone to a doctor in my section's outpatient service.It is existing symptoms include: Bilateral lumbar, buttocks dull pain, ache influence are suffered from Person's sleep occasionally has cough with double lower limb feeling of numbness, and without coughing up phlegm, limitation of activity, unparalleled lower limb rediating pain, thorax abdomen is multiple to be dispersed in Erythema, limb is soft out of strength, and spirit still, receives food still, sleeps not good enough, and catheter conduction is unobstructed, and stool is fine.NRS scores 6 points.Phase Between give drug of the present invention (being made by embodiment 1) carry out Chinese medicine keritherapy after a week, pain is clearly better, NRS score 2 points, Stool and urine is normal, and patient is discharged from hospitals upon recovery after continual cure 1 week.

5, patient Chen Mingzhen；Gender: female；Age: 54 years old；Department: oncology；Time: on February 25th, 2018；Make a definite diagnosis palace 6+ after neck cancer operation chemotherapy, the Lung metastases complex treatment postoperative 3+ month；There is irregular yin without obvious inducement before patient 6 years Road is bled, and color is dark red, accompanies blood clot, and the discomforts such as no lower abdominal pain, pruritus vulvue are gone to a doctor in " Guiyang College of Traditional Chinese Medicine Two affiliated hospitals " row cervical tissue biopsy is clearly " cervical carcinoma ", is carried out " through abdomen radical hysterectomy+bilateral attachment Resection+pelvic lymphadenectomy ", postoperative pathological: squamous carcinoma of cervix, middle differentiation are postoperative to give TC scheme chemotherapy 1 Leave hospital after a period.It is not checked after discharge.It spat blood, goes to a doctor then in Guiyang First People's Hospital without obvious inducement before 3 years, Row chest CT: " double multiple lesions of lung consider pernicious, lung cancer, vertical diaphragm and bilateral nodi lymphatici axillares are shown, Drug eluting stent Pathology shows: looking into and sees medium-low differentiation squamous cell carcinoma, is inclined to uterine neck metastasis of cancer.4 period of TC scheme chemotherapy is given, symptom of spitting blood It improves.CT therapeutic evaluation: part alleviate, after use instead 2 period of (docetaxel+carboplatin) chemotherapy, imageological examination Hui Shi lung turn Move foci disappearance.Two years ago check chest CT is shown: " double upper Lung neoplasm shadows consider transfer " gives TP (taxol+cis-platinum) chemotherapy 5 periods, therapeutic evaluation after chemotherapy: complete incidence graph.Checked chest CT before 1 year to show: " left Lung metastases tubercle " gives IP scenario: In 2 period of Irinotecan+cisplatin chemotherapy, check chest CT again and show: left Lung metastases tubercle has no significant change.And gradually appear a left side Upper arm pain influences to sleep, interruption oral hydrochloride morphine piece, Gabapentin Tablets treatment (detailed directions are unknown), then in forward in March It examines in Guiyang tumour hospital row " DSA and class CT Guided Percutaneous upper left lung mass puncture radio-frequency ablation procedure ", postoperative upper left There is repeated coughing, coughs up phlegm without alleviation in arm pain.The present goes to a doctor in our hospital's outpatient service.Existing symptoms include left upper arm pain, shortness of breath gas is tired, Yellowish-white viscous phlegm is coughed up in cough, and amount is few, is not easy to bring up, limb is soft out of strength, and spirit is withered soft.NRS scores 5 points, during which gives drug of the present invention (being made by embodiment 1) is applied with waist and removes obstruction in channels to relieve pain after a week, and spirit and pain are clearly better, and NRS scores 2 points, patient It is discharged from hospitals upon recovery.

6, patient's name: Chen Zhengying；Gender: female；Age: 77 years old；Department: oncology；Time: on 04 17th, 2018, It makes a definite diagnosis the cervical squamous cancer 1+ month, chemotherapy interventional embolization postoperative 4 days.There is colporrhagia without obvious inducement before patient January, Without abdominal pain diarrhea, the diseases such as fever with aversion to cold, voluntarily taking orally " blood flow soft capsule " (specifically unknown), symptom has no alleviation afterwards, is further Detailed diagnosis and treatment, gone to a doctor then in gynaecology, our hospital, the prompt of row Gynaecological B ultrasound: uterine neck and uterine cavity high echogenic mass consider occupying lesion, Uterine cavity cystic occupying lesion, fibroid, post menopausal uterus.Pelvic MRI, which is returned, to be shown: uterine neck occupy-place considers uterine neck CA Possibility is big, and lesion involves corpus uteri and vagina upper section, vagina lower section agglomerate shadow；Hematocele in uterine cavity/hydrops；Left acetabulum leading edge, The multiple patch shadow of bilateral sacroiliac joint surface, inflammatory change, or transfer,.It is recommended that patient's row operative treatment, family numbers of patients refusal, give Symptom, which improves, after the symptomatic treatments such as anti-infective, hemostasis leaves hospital.There is colporrhagia repeatedly in patient afterwards, is further detailed diagnosis and treatment, Then it goes to a doctor and is prompted in " Guiyang healthcare hospital for women & children " row cervical tissue biopsy: squamous cell carcinoma, middle differentiation.Immunohistochemistry is shown: P40 (+), P63 (+), CKLMW (a small amount of cell+), P16(diffuses+), Ki-67 (about 50%-60%).The diagnosis of patient's cervical squamous cell carcinoma is bright Really, it is further detailed diagnosis and treatment, is gone to a doctor then in " The People's Hospital of Peking University ", it is proposed that patient's row Radiotherapy chemotherapy, family numbers of patients considers Patient is not resistant to therefore refuses, and patient's colporrhagia aggravates before 4 days, goes to a doctor in " Zhanlan Road, Xicheng District, Beijing City hospital ", excludes Row " taxol 80mg " chemotherapy interventional embolization after obvious taboo, postoperative vaginal are bled alleviation, but nausea and vomiting are obvious, through product Remission is left hospital after the symptomatic treatment of pole.Modern patient assessment is in our hospital's outpatient service.Weight loss about 2kg since patient's idiopathy.It is existing Symptoms include sallow complexion, limb is soft out of strength, lower abdomen and waist dull pain, Non-vaginal bleeding, receive food still, not good enough, urine tune of sleeping, and difficulty in defecation Solution.NRS scores 7 points.Period gives drug of the present invention (being made by embodiment 1) external application waist and removes obstruction in channels to relieve pain after a week, spirit It is clearly better with pain, NRS scoring is down to 3 points.

7, patient Liao Damei；Gender: female；Age: 78 years old；Department: oncology；Time: on October 24th, 2018；Make a definite diagnosis larynx 3+ after cancer postoperation radiotherapy.There is trachyphonia without obvious inducement in patient before 3 years, is in duration, no thirsty and pharyngalgia, no cough It coughs, the discomforts such as expectoration are gone to a doctor then in " Guiyang First People's Hospital " row throat enhanced CT+three-dimensional reconstruction: prompt cavum laryngis glottis Lower margo dexter tubercle shadow property, polyp, increase in density shadow property in right side increased thickness of vocal cords, right side nasal cavity, polyp may.It is right Side maxillary sinusitis, laryngoscope show: neoformation under glottis, therefore throat is newborn under general anesthesia downlink supporting laryngoscope after excluding surgical contraindication Object low-temperature plasma resection, postoperative pathological show: " having under glottis " cellule type neuroendocrine carcinoma is clarified a diagnosis as laryngocarcinoma (I phase of glottis mo(u)ld bottom half small cell neuroendocrine carcinoma T1N0M0) goes to a doctor for further detailed diagnosis and treatment in " Guizhou Province people doctor 33 radiotherapies (specifically unknown) of institute " row radical-ability.Periodic review outside institute prompts stable disease, has no transfer.Patient before half a year There is right side the small of the back size about 6cm × 3cm mass in no obvious inducement, without pain, year go to a doctor in " Guizhou Province People's Hospital " It looks into liver MRI+ abdomen DWI to show: right adrenal gland transfer.Parallel right side the small of the back mass puncture biopsy, postoperative pathological mention Show: seeing that heterocyst infiltrates in fibr tissue, be inclined to tumour.Consider the transfer of patient's laryngocarcinoma, it is proposed that chemotherapy, but patient and family members examine Consider patient's advanced age, chemotherapy cannot be resistant to, therefore refuse chemotherapy.Now to go to a doctor in our hospital's outpatient service is existing symptoms include left lumbar mass, size About 6cm × 3cm, matter is hard, and no tenderness, what is pushed away does not move, when have a trachyphonia, dry throat, waist distending pain, walking and while standing aggravate, lie down And alleviate when rest, limb is soft out of strength, occasionally there is nervous uncomfortable in chest, unparalleled edema of lower extremity, no chilly, fever, no hectic fever, night sweat, no cough Cough, cough up phlegm, spirit can, appetite is not good enough, dormancy can, two.NRS scores 7 points.Period give drug of the present invention (by embodiment 1 into Row production) be applied with waist remove obstruction in channels to relieve pain after a week, pain is clearly better, NRS score 3 points.

8, patient's name: Yang Xianyong；Gender: male；Age: 45 years old；Department: oncology；Time: on 09 17th, 2018； It makes a definite diagnosis lower-left adenocarcinoma of lung and the multiple transfer 4+ month, after 4 journey chemotherapy.There is cough, expectoration without obvious inducement in patient before April, even There is blood-stained sputum, with left chest dull pain, ache influence patient sleeps, no fever with aversion to cold, no hectic fever night sweat, it is not intended to know obstacle etc. no It is suitable, it is gone to a doctor then in the unenhanced prompt of " In Qiannan the People's Hospital " row chest CT: considering lower-left lung CA with obstructive pneumonia, with left The multiple metastatic tumor of lung, left side pleura metastasis；Left inside cream lymphatic metastasis；Left side pleural effusion；Left and right coronary atherosclerosis. Because occupy-place is close to heart, puncture risks are big, it is proposed that patient transfers from one hospital to another further diagnosis and treatment.Patient goes to a doctor in " Zhongshan University's tumour is anti-afterwards Control " center " row thorax abdomen enhancing+plain CT to show: lower-left lung neoplasms consider that lung cancer possibility is big；Lower-left lung inflammation is with limitation Atelectasis；Pleura inferior thyroid tubercle by left lobe mediastinum considers metastatic tumor；Left side pleural nodulations shape thickens, and considers transfer；Left side chest Chamber hydrops；Left side cardio-diaphragmatic angle, mediastinum, the multiple lymph node of left hilus pulumonis consider transfer；Part tubercle before the greater psoas muscle of right side considers transfer Tumor；Liver S8 tumour, liver S6 Glisson's capsule calcification.Further row bronchoscopy shows: lower-left lung cancer.Pathological replacement shows: (left Each basal segment of lower lung is open swollen object) smear is shown in the specific cell for being dispersed in distribution, form meets non-small cell cancer cell, is thought of as gland Cancer cell.It is recommended that patient's row chemotherapy, patient's refusal.It goes to a doctor for further therapy of combing traditional Chinese and Western medicine in my section, it is super to look into Pleural effusions B Return and show: a large amount of pleural effusions in left side, after giving drain pleural effusion, patient improves after row elemene perfusion chemotherapy.Exclude obviousization After treating taboo, respectively at 2018-06-21,2018-07-13,2018-08-03,2018-08-24 row pemetrexed 800mg+ Nedaplatin 160mg chemotherapy, chemotherapy process are smooth.The present goes to a doctor to be admitted to hospital to check in our hospital.It is existing symptoms include: left side chest side of body portion is numb Sense, still, sallow complexion, limb is soft out of strength for spirit, without obvious cough, coughs up phlegm, and receives dormancy still, and two.NRS scores 7 points.Both Toward 7+ " hypertension " medical history, blood pressure is up to 150/110mmHg, and non-rule takes depressor, and readme controlling of blood pressure is fine. Period gives drug of the present invention (being made by embodiment 1) external application left side chest and removes obstruction in channels to relieve pain, and after a week, pain is clearly better, NRS scores 2 points.Patient is discharged from hospitals upon recovery after continual cure 1 week.

9, patient Tang Ji；Gender: male；Age: 63 years old；Department: oncology；Time: on May 28th, 2018；Make a definite diagnosis the right side Adenocarcinoma of lung and double lungs, vertical diaphragm, pleura metastasis 1+, the 2+ month after chemotherapy.Occur on the right side of shoulder before patient 1 year without obvious inducement Scapular region pain, at that time without fever with aversion to cold, nausea and vomiting, the diseases such as redness are gone to a doctor in Guizhou affiliated hospital, medical university row chest CT prompt: superior lobe of right lung apical segment lump, lung neoplasm is possible, and double Lung neoplasms, part tubercle is shifted wait arrange, and vertical phrenic lymph nodes increase, Part increases, and goes to a doctor for further treatment in Huaxi Hospital Attached to Sichuan Univ, guides downlink Drug eluting stent art, art in CT Our hospital's disease inspection afterwards is shown: right upper lung, which is looked into, sees gland cancer, PD-L1(-), EGFR(-), chest CT, which is returned, to be shown: superior lobe of right lung apical segment lump, lung are swollen Tumor is possible, and double Lung neoplasms, part tubercle is shifted wait arrange, and vertical phrenic lymph nodes increase, and part increases, right side pleural nodulations, and pleura turns Move may, after excluding chemotherapy contraindication, 6 cycle T C scheme chemotherapy of row, limb end sense numbness shouting pain after chemotherapy, the 2nd, 4,6 periods therapeutic evaluation SD, it is proposed that patient's row list medicine taxol maintenance therapy, patient and its family members' refusal, patient before March Thorax abdomen enhanced CT is checked to prompt: 1. superior lobe of right lung apical segment lumps, polyphyly lung Ca, compared with 2017-12-27CT old film, Lump volume increases；2. pair Lung neoplasm, part tubercle transfer stove is possible, and more above-mentioned old film has no significant change；3. right side pleura Tubercle, pleura metastasis, more above-mentioned old film, part tubercle increases, incorporated by reference to clinic；4. pair branch, lung tracheae is slightly expanded with sense Dye；5. vertical phrenic lymph nodes increase, part increases；6. aorta wall and arteria coroaria sinistra wall calcification；7. the small tumour of right lobe of liver；8. pair Renal cyst；Left renal artery calcification；9. abdominal aorta and bilateral arteria iliaca communis wall calcification and wall thrombus；Patient lungs and pleura disease Stove significantly increases earlier above, therapeutic evaluation PD, and pemetrexed chemotherapy is used in consideration instead, for convenient for treatment, patient assessment is in interior before the 2+ month Leave hospital after the People's Hospital Jiang Shi row cis-platinum+2 course for the treatment of of pemetrexed chemotherapy, patient gradually appears extremity numbness after chemotherapy, after in I shows section's row chest enhanced CT: 1. superior lobe of right lung occupy-places, incorporated by reference to clinic；2. superior lobe of right lung oldness lesion；3. right side chest Film thickens, therapeutic evaluation PR, it is proposed that the further row chemotherapy of patient, but family members refuse, automatic discharge of signing, patient's right chest at present Portion, right omoplate and right upper extremity pain aggravate, and with extremity numbness, are gone to a doctor again in our hospital.Now symptoms include ward is stepped into, spirit is fine, Right chest, right omoplate and right upper extremity pain, right upper extremity and double-legged bottom are numb, and limb is soft out of strength, and dormancy of receiving is poor, and urine is difficult, and defecate 2- 3 days/time.NRS scores 6 points.The past body is strong.Period gives scapular region on the right side of drug of the present invention (being made by embodiment 1), and one Zhou Hou, pain are clearly better, and NRS scores 3 points.

Invention is further described below with reference to embodiment, but is not intended as the foundation limited the present invention.

Specific embodiment:

Embodiment 1.

Formula: naze 6g, arisacma consanguineum schott 10g, Radix Aconiti 10g and centipede 2.

Preparation method: taking the above medicinal material, is that 1:20 is soaked in water for 24 hours by the weight ratio of medicinal material and water, filtrate is abandoned, by solid The weight ratio of the dregs of a decoction and edible sesame oil is that 1:2 weighs edible sesame oil, the solid dregs of a decoction and edible sesame oil in 145-155 DEG C of holding azeotropic 30min stands cooling supernatant；It is that 1:2 weighs 80 DEG C of moltens of beeswax by the weight ratio of edible sesame oil and wax, is slowly added to oil Phase supernatant, stirs evenly 20min, cooling and solidifying to get.

Usage and dosage: in use, the wax therapy ointment is crossed micro-wave oven or other way heating, become to starch to solid fraction ointment Paste dress fashionable dress enters in pallet, after wax surface peeling, lotion is externally applied to body affected part, lid insulation turns cold to lotion Afterwards, lotion is shut down from skin surface, is prepared and easy to use.

Embodiment 2.

Formula: naze 7g, arisacma consanguineum schott 12g, Radix Aconiti 12g and centipede 2.5g.

Preparation method: while example 1.

Usage and dosage: while example 1.

Embodiment 3.

Formula: naze 5g, arisacma consanguineum schott 8g, Radix Aconiti 8g and centipede 1.5g.

Preparation method: while example 1.

Usage and dosage: while example 1.

Claims (7)

1. a kind of drug of Chinese medicine keritherapy treatment cancer pain, it is characterised in that: calculate by weight, mainly by 3-9 parts of naze, 5-15 parts of arisacma consanguineum schott, 5-15 parts of Radix Aconiti and 1-3 parts of centipede are made.

2. the drug of Chinese medicine keritherapy treatment cancer pain as described in claim 1, it is characterised in that: it calculates by weight, it is main It to be made of 5-7 parts of naze, 8-12 parts of arisacma consanguineum schott, 8-12 parts of Radix Aconiti and 1.5-2.5 parts of centipede.

3. the drug of Chinese medicine keritherapy treatment cancer pain as claimed in claim 2, it is characterised in that: it calculates by weight, it is main It to be made of 6 parts of naze, 10 parts of arisacma consanguineum schott, 10 parts of Radix Aconiti and 2 parts of centipede.

4. a kind of production method of the drug of Chinese medicine keritherapy treatment cancer pain as claimed in any one of claims 1-3, It is characterized in that: taking said medicine, auxiliary material can be added, auxiliary material can also be not added, external preparation is made.

5. the production method of the drug of Chinese medicine keritherapy treatment cancer pain as claimed in claim 4, it is characterised in that: described outer It is wax therapy ointment with preparation.

6. the production method of the drug of Chinese medicine keritherapy treatment cancer pain as claimed in claim 5, it is characterised in that: the wax It treats ointment to be prepared: taking the above medicinal material, be that 1:20 is soaked in water for 24 hours by the weight ratio of medicinal material and water, abandon filtrate, the solid dregs of a decoction With edible sesame oil in 145-155 DEG C of holding azeotropic 30min, cooling supernatant is stood；Weight ratio by edible sesame oil and wax is 1:2 weighs 80 DEG C of moltens of beeswax, is slowly added to oily phase supernatant, stirs evenly 20min, cooling and solidifying to get.

7. the production method of the drug of Chinese medicine keritherapy treatment cancer pain as claimed in claim 6, it is characterised in that: described solid The weight ratio of the body dregs of a decoction and edible sesame oil is 1:2.