CN109715185A - 水溶性且化学稳定的胰高血糖素肽 - Google Patents

水溶性且化学稳定的胰高血糖素肽 Download PDF

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Publication number
CN109715185A
CN109715185A CN201780034107.XA CN201780034107A CN109715185A CN 109715185 A CN109715185 A CN 109715185A CN 201780034107 A CN201780034107 A CN 201780034107A CN 109715185 A CN109715185 A CN 109715185A
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CN
China
Prior art keywords
amino acid
peptide
glucagon peptide
seq
glucagon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780034107.XA
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English (en)
Chinese (zh)
Inventor
R.D.迪马基
J.P.迈尔
P.姆罗斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indiana University Research and Technology Corp
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Indiana University Research and Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Indiana University Research and Technology Corp filed Critical Indiana University Research and Technology Corp
Publication of CN109715185A publication Critical patent/CN109715185A/zh
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201780034107.XA 2016-06-02 2017-05-31 水溶性且化学稳定的胰高血糖素肽 Pending CN109715185A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662344672P 2016-06-02 2016-06-02
US62/344672 2016-06-02
PCT/US2017/035101 WO2017210241A1 (en) 2016-06-02 2017-05-31 Aqueously soluble & chemically stable glucagon peptides

Publications (1)

Publication Number Publication Date
CN109715185A true CN109715185A (zh) 2019-05-03

Family

ID=60478926

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780034107.XA Pending CN109715185A (zh) 2016-06-02 2017-05-31 水溶性且化学稳定的胰高血糖素肽

Country Status (5)

Country Link
US (1) US10683334B2 (enExample)
EP (1) EP3463415A4 (enExample)
JP (1) JP2019520336A (enExample)
CN (1) CN109715185A (enExample)
WO (1) WO2017210241A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113396156A (zh) * 2019-02-05 2021-09-14 伊莱利利公司 胰高血糖素类似物激动剂及其使用方法
CN117242098A (zh) * 2021-02-09 2023-12-15 印地安纳大学理事会 构象受限的胰高血糖素类似物及其在胰高血糖素-单链胰岛素融合蛋白中的用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1342166A (zh) * 1998-12-07 2002-03-27 研究及应用科学协会股份有限公司 胰高血糖素样肽-1的类似物
CN101790538A (zh) * 2007-02-15 2010-07-28 印第安纳大学研究与科技公司 胰高血糖素/glp-1受体共激动剂
CN102088989A (zh) * 2008-06-17 2011-06-08 印第安纳大学研究及科技有限公司 在生理pH缓冲液中具有增强的溶解性和稳定性的胰高血糖素类似物
CN102348715A (zh) * 2009-02-03 2012-02-08 阿穆尼克斯运营公司 延伸重组多肽和包含该延伸重组多肽的组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877277A (en) 1987-09-24 1999-03-02 Biomeasure, Inc. Octapeptide bombesin analogs
US20020090646A1 (en) 2000-05-03 2002-07-11 Amgen Inc. Calcitonin-related molecules
US20070060512A1 (en) 2003-03-04 2007-03-15 Homayoun Sadeghi Dipeptidyl-peptidase protected protein
EP2021014A1 (en) 2006-05-26 2009-02-11 Brystol-Myers Squibb Company Sustained release glp-1 receptor modulators
KR101382593B1 (ko) * 2010-07-21 2014-04-10 한미사이언스 주식회사 신규한 지속형 글루카곤 결합체 및 이를 포함하는 비만 예방 및 치료용 약학적 조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1342166A (zh) * 1998-12-07 2002-03-27 研究及应用科学协会股份有限公司 胰高血糖素样肽-1的类似物
CN101790538A (zh) * 2007-02-15 2010-07-28 印第安纳大学研究与科技公司 胰高血糖素/glp-1受体共激动剂
CN102088989A (zh) * 2008-06-17 2011-06-08 印第安纳大学研究及科技有限公司 在生理pH缓冲液中具有增强的溶解性和稳定性的胰高血糖素类似物
CN102348715A (zh) * 2009-02-03 2012-02-08 阿穆尼克斯运营公司 延伸重组多肽和包含该延伸重组多肽的组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
陆彬: "《药剂学》", 31 January 2003 *

Also Published As

Publication number Publication date
US10683334B2 (en) 2020-06-16
WO2017210241A1 (en) 2017-12-07
EP3463415A4 (en) 2020-03-25
EP3463415A1 (en) 2019-04-10
JP2019520336A (ja) 2019-07-18
US20190218268A1 (en) 2019-07-18

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Application publication date: 20190503