CN109700426A - Portable AO-OCT imaging device - Google Patents
Portable AO-OCT imaging device Download PDFInfo
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- CN109700426A CN109700426A CN201910081022.8A CN201910081022A CN109700426A CN 109700426 A CN109700426 A CN 109700426A CN 201910081022 A CN201910081022 A CN 201910081022A CN 109700426 A CN109700426 A CN 109700426A
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- 238000003384 imaging method Methods 0.000 title claims abstract description 33
- 239000000835 fiber Substances 0.000 claims abstract description 32
- 239000013307 optical fiber Substances 0.000 claims abstract description 9
- 238000007689 inspection Methods 0.000 claims abstract description 8
- 238000001514 detection method Methods 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims description 10
- 230000010287 polarization Effects 0.000 claims description 7
- 230000004075 alteration Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 abstract description 4
- 230000008569 process Effects 0.000 abstract description 3
- 239000000523 sample Substances 0.000 description 18
- 238000012014 optical coherence tomography Methods 0.000 description 14
- 210000001508 eye Anatomy 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 210000001525 retina Anatomy 0.000 description 3
- 230000003044 adaptive effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 108091008695 photoreceptors Proteins 0.000 description 2
- 208000017442 Retinal disease Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 210000002592 gangliocyte Anatomy 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000010349 pulsation Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 210000000880 retinal rod photoreceptor cell Anatomy 0.000 description 1
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- Investigating Or Analysing Materials By Optical Means (AREA)
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Abstract
The present invention provides a kind of portable AO-OCT imaging device, including cabinet and hand hold transducer, is connected between the cabinet and hand hold transducer by optical fiber；Light source, fiber coupler, reference arm, sample arm and spectrometer are equipped in the cabinet, optical fiber connects each other；Wherein the sample arm includes Wavefront sensor, spectroscope and distorting lens, and inspection scan flow instrument is equipped in the hand hold transducer, is imaged for Scanning Detction object；The device is made into hand hold transducer for integrating in a scan close to the part lens of human eye, realizes handhold functional by integrating, rest part is integrated in cabinet, easy to carry, facilitates operation, sufferer be can also be improved to the comfort level of inspection, preferably to service infant.And the device imaging process is friendly, noninvasive lossless, time-consuming short, imaging resolution is high, enables the clinician to quick and accurate analysing patient's condition, expense is cheap, is expected to industrialization, becomes medical staff in the standard detection tools of ophthalmology.
Description
Technical field
The invention belongs to optical image technology fields, and in particular to a kind of portable AO-OCT imaging device.
Background technique
Means of optical coherence tomography (OCT) has become the important tool of detection retinal disease.However, such as year
The potential mechanism of diseases such as age macular degeneration related (AMD) or diabetes cretinism is still not well known.In order to deeper into
Understand the pathogenesis of these diseases, need to detect the information in retina cell's level in the living body.
Current commercialization OCT instrument lacks the lateral resolution of enough cell imagings, thus the imaging of cellular level by
Limitation, and in healthy human eye only under given conditions can just see individual cells, such as taper photoreceptor.In order to gram
This limitation is taken, is usually combined adaptive optics (AO) with OCT, adaptive optics (AO) substantially improves optics view
The lateral resolution of film imaging, compared with standard OCT image, the high collection efficiency that AO auxiliary device provides has improved blood vessel
Contrast, the no color differnece aberration of eyes can be corrected, improve the resolution of retinal microvascular under existing clinical imaging ability
Rate.AO-OCT can show the various cell types in retina, such as taper photoreceptor, rod photoreceptors, retina
Pigment epithelial cell, red blood cell even gangliocyte.However, converting these devices to a specific challenge of diagnosis and treatment instrument
Property the problem of be instrument volume it is quite big, occupy very large space.
Summary of the invention
It is an object of the present invention to provide a kind of portable AO-OCT imaging devices, mainly for infant, because of infant
It can be more difficult when checking eyes.
In order to reach above-mentioned technical purpose, technical scheme is as follows: a kind of portable AO-OCT imaging device, packet
Cabinet and hand hold transducer are included, is connected between the cabinet and hand hold transducer by optical fiber；
Light source, fiber coupler, reference arm, sample arm and spectrometer are equipped in the cabinet, optical fiber connects each other；
Wherein the sample arm includes Wavefront sensor, spectroscope and distorting lens, and inspection scan flow instrument is equipped in the hand hold transducer, is used for
The imaging of Scanning Detction object；
The light that light source issues respectively enters reference arm and sample arm after fiber coupler is divided, wherein entering sample arm
Light reach spectroscope after, fraction transmitted through spectroscope reach Wavefront sensor；Largely be split mirror reflection, then gets to
It on distorting lens, then is conducted through reflection and enters the hand hold transducer, be scanned through inspection scan flow instrument to detection target, after scanning
Light retroeflection, backtracking enter sample arm, and when reaching spectroscope, are again divided into two parts, and a part penetrates
Spectroscope calibrates distorting lens with the wave front aberration for detecting return projector into Wavefront sensor；Another part is through being divided
Mirror reflection, into fiber coupler, the light that final sample arm and reference arm are reflected back interferes after entering fiber coupler, shape
At interference light, is received and be imaged by spectrometer.
Light source is usually the light of near infrared band, it is preferable that the wavelength of the light source be 750nm-850nm, more conducively at
Picture.
Fiber coupler is mainly used for being divided, it is preferable that and the fiber coupler is 50/50 fiber coupler, so as to
To better interference signal.
The common lens focus for being typically referenced to the focusing system use of arm is reflected to reflecting mirror, it is preferable that described
Reference arm includes the first condenser lens, liquid lens, gun sight and the first reflecting mirror, and the light beam of entrance successively passes through the first focusing
The reflection of the first reflecting mirror is focused on after lens, liquid lens, gun sight, then backtracking to fiber coupler.Use liquid
Lens can change focal length by changing the curvature of liquid in this way, so as to adapt to different eye-lengths.
Preferably, the sample arm further includes the second condenser lens, and the second reflecting mirror, third reflecting mirror, the second collimation is thoroughly
Mirror, third collimation lens, the 4th reflecting mirror and first collimator reach into the light of sample arm after the second condenser lens
Two-mirror reflection, then reaches spectroscope, and a portion sequentially enters the second collimation lens, third standard through spectroscope reflection
Straight lens, then reach distorting lens, reflect after distorting lens through the 4th reflecting mirror, into first collimator, then pass through light
Fibre enters portion of the handle；Another part, which is reflected through spectroscope through third reflecting mirror, reaches Wavefront sensor.
Preferably, the hand hold transducer includes the second collimator, the 4th condenser lens, galvanometric scanners, the 5th reflection
Mirror and the 5th condenser lens, the light beam of entrance focus to galvanometer through the 4th condenser lens and sweep after the second collimator collimation
Instrument is retouched, is then reflected into the 5th focus lamp through the 5th reflecting mirror, focuses to sample to be tested through the 5th focus lamp.
Preferably, the spectrometer includes the first collimation lens, grating, tertiary focusing lens and camera, the interference light
By being divided by grating by wavelength after the first collimation lens collimation, through tertiary focusing lens focus to camera imaging.
Preferably, between the fiber coupler and reference arm, between the fiber coupler and sample arm and the light
Polarization Controller is further respectively had between fine coupler and the spectrometer, preferably to control the polarization state of each optical path, is protected
Demonstrate,prove the consistency of signal.
Portable AO-OCT imaging device provided by the invention, will be in a scan close to the part lens of human eye by integrated
It integrating and is made into hand hold transducer, realize handhold functional, rest part is integrated in cabinet, and it is easy to carry, facilitate operation,
Sufferer can be improved to the comfort level of inspection, preferably to service infant.
Detailed description of the invention
Fig. 1 is that the optical coherence tomography structure for measuring eyeball pulsation that the embodiment of the present invention 1 provides is shown
It is intended to.
Specific embodiment
The technical solution that the present invention will be described in detail in the following with reference to the drawings and specific embodiments.
Embodiment 1
Shown in referring to Fig.1, a kind of portable AO-OCT imaging device, including cabinet 1 and hand hold transducer 2, cabinet 1 and hand-held
It is connected between probe 2 by optical fiber.
Light source 3, fiber coupler 4, reference arm, sample arm and spectrometer are equipped in cabinet 1, optical fiber connects each other.
The wavelength of light source 3 is 750nm-850nm, and fiber coupler 4 is 50/50 fiber coupler.
Reference arm includes the first condenser lens 5, liquid lens 6, gun sight 7 and the first reflecting mirror 28.
Sample arm includes the second condenser lens 8, the second reflecting mirror 9, spectroscope 10, third reflecting mirror 16, Wavefront sensor
17, the second collimation lens 11, third collimation lens 12, distorting lens 13, the 4th reflecting mirror 14, first collimator 15.
Hand hold transducer 2 includes the second collimator 18, the 4th condenser lens 19, galvanometric scanners 20, the 5th reflecting mirror 21
With the 5th condenser lens 22.
Spectrometer includes the first collimation lens 23, grating 24, tertiary focusing lens 25 and camera 26.
The light that light source 3 issues, into after 50/50 fiber coupler 4, portion is two, and a part enters sample arm, a part
Into reference arm.
Into the light of reference arm, directional light is formed after the first condenser lens 5, then in turn through liquid lens 6, is taken aim at
Quasi- mirror 7 focuses on the first reflecting mirror 28, and backtracking enters fiber coupler 4 after the reflection of the first reflecting mirror 28.
Into the light of sample arm, at directional light, then it is reflected into through the second reflecting mirror 9 by after the second condenser lens 8
Up to spectroscope 10, wherein fraction, which is reflected transmitted through spectroscope 10 through third reflecting mirror 16, reaches Wavefront sensor 17；It is most of
The mirror 10 that is split reflection, successively focuses on distorting lens 13 by the second collimation lens 11, third collimation lens 12, then through becoming
Shape mirror 13 is reflected on the 4th reflecting mirror 14, then is reflected into first collimator 15 through the 4th reflecting mirror 14 and is collimated, then through light
Fibre enters hand hold transducer 2, into after hand hold transducer, first passes through the second collimator 18 collimation, then passes through the 4th condenser lens 19
Galvanometric scanners 20 are focused on, is reflected through galvanometric scanners 20 and reaches the 5th reflecting mirror 21, are reflected through the 5th reflecting mirror 21
Laggard the 5th condenser lens 22 of mistake focuses on eyeground to be measured, is scanned, and light is scattered along backtracking backward after scanning, and
When reaching spectroscope 10, two parts are again divided into, a part penetrates spectroscope 10, returns into Wavefront sensor 17 to detect
The wave front aberration of light, and then distorting lens 13 is calibrated；Another part is reflected through spectroscope 10, into fiber coupler 4.
The light that final sample arm and reference arm are reflected back interferes after entering fiber coupler 4, forms interference light, interference
Light enters spectrometer, first by being divided by grating 24 by wavelength after the first collimation lens 23 collimation, focuses through tertiary focusing lens 25
It is imaged to camera 26.
In order to enable the polarization state of each section light is consistent, imaging effect is more preferable, between fiber coupler 4 and reference arm, light
Polarization Controller 27 is further respectively had between fine coupler 4 and sample arm and between fiber coupler 4 and spectrometer.
The optical coherence tomography that embodiment 1 provides have it is following the utility model has the advantages that
1, by integrating, it is made into hand hold transducer by integrating in a scan close to the part lens of human eye, realizes hand
Function is held, rest part is integrated in cabinet, more compact portable, facilitates operation, it can also be improved sufferer to the comfort level of inspection,
Preferably to service infant.
2, in imaging process, in sample arm, a spectroscope 10 is placed before Wavefront sensor 16, can be divided progress
Wavefront measurement is corrected imaging, and such imaging resolution is higher.
3, liquid lens 6 is used in reference arm, the characteristic that can be changed using liquid lens focal length is adjustable to be adapted to difference
Eye-length.
4, Polarization Controller 27 is set in each branch optical path, so that each optical path polarization state is consistent, so that imaging signal is more
Stablize.
5, the device imaging process is friendly, noninvasive lossless, and time-consuming short, imaging resolution is high, enables the clinician to quick and accurate
Analysing patient's condition, expense is cheap, is expected to industrialization, becomes medical staff in the standard detection tools of ophthalmology.
According to the disclosure and teachings of the above specification, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and is modified.Therefore, the invention is not limited to the specific embodiments disclosed and described above, to of the invention
Some modifications and changes should also be as falling into the scope of the claims of the present invention.In addition, although being used in this specification
Some specific terms, these terms are merely for convenience of description, does not limit the present invention in any way.
Claims (8)
1. portable AO-OCT imaging device, which is characterized in that including cabinet and hand hold transducer, the cabinet and hand hold transducer it
Between pass through optical fiber connect；
Light source, fiber coupler, reference arm, sample arm and spectrometer are equipped in the cabinet, optical fiber connects each other；Wherein
The sample arm includes Wavefront sensor, spectroscope and distorting lens, inspection scan flow instrument is equipped in the hand hold transducer, for scanning
Test object imaging；
The light that light source issues respectively enters reference arm and sample arm after fiber coupler is divided, wherein entering the light of sample arm
After reaching spectroscope, fraction reaches Wavefront sensor transmitted through spectroscope；Largely be split mirror reflection, then gets to deformation
It on mirror, then is conducted through reflection and enters the hand hold transducer, be scanned through inspection scan flow instrument to detection target, the light after scanning
Retroeflection, backtracking enter sample arm, and when reaching spectroscope, are again divided into two parts, a part is through light splitting
Mirror calibrates distorting lens with the wave front aberration for detecting return projector into Wavefront sensor；Another part is anti-through spectroscope
It penetrates, into fiber coupler, the light that final sample arm and reference arm are reflected back interferes after entering fiber coupler, is formed dry
Light is related to, is received and is imaged by spectrometer.
2. portable AO-OCT imaging device according to claim 1, which is characterized in that the wavelength of the light source is
750nm-850nm。
3. portable AO-OCT imaging device according to claim 1, which is characterized in that the fiber coupler is 50/
50 fiber couplers.
4. portable AO-OCT imaging device according to claim 1, which is characterized in that the reference arm includes first poly-
Focus lens, liquid lens, gun sight and the first reflecting mirror, the light beam of entrance successively pass through the first condenser lens, liquid lens, take aim at
The reflection of the first reflecting mirror is focused on after quasi- mirror, then backtracking to fiber coupler.
5. portable AO-OCT imaging device according to claim 1, which is characterized in that the sample arm further includes second
Condenser lens, the second reflecting mirror, third reflecting mirror, the second collimation lens, third collimation lens, the 4th reflecting mirror and the first collimation
Device reaches the reflection of the second reflecting mirror after the second condenser lens, spectroscope is then reached, wherein one into the light of sample arm
The reflection of lease making spectroscope sequentially enters the second collimation lens, third collimation lens, then reaches distorting lens, passes through after distorting lens
The reflection of 4th reflecting mirror, into first collimator, then enters portion of the handle by optical fiber；Another part is through spectroscope through the
The reflection of three reflecting mirrors reaches Wavefront sensor.
6. portable AO-OCT imaging device according to claim 1, which is characterized in that the hand hold transducer includes second
The light beam of collimator, the 4th condenser lens, galvanometric scanners, the 5th reflecting mirror and the 5th condenser lens, entrance passes through second
After collimator collimation, galvanometric scanners are focused to through the 4th condenser lens, it is poly- to be then reflected into the 5th through the 5th reflecting mirror
Jiao Jing focuses to sample to be tested through the 5th focus lamp.
7. portable AO-OCT imaging device according to claim 1, which is characterized in that the spectrometer includes first quasi-
Straight lens, grating, tertiary focusing lens and camera, the interference light are divided by grating by wavelength after being collimated by the first collimation lens
Light, through tertiary focusing lens focus to camera imaging.
8. portable AO-OCT imaging device according to claim 1, which is characterized in that the fiber coupler and reference
Between arm, further respectively had between the fiber coupler and sample arm and between the fiber coupler and the spectrometer
Polarization Controller.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910081022.8A CN109700426B (en) | 2019-01-28 | 2019-01-28 | Portable AO-OCT imaging device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910081022.8A CN109700426B (en) | 2019-01-28 | 2019-01-28 | Portable AO-OCT imaging device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111627085A (en) * | 2020-06-01 | 2020-09-04 | 中国科学院长春光学精密机械与物理研究所 | Wavefront sub-field curvature sensing method and device and self-adaptive OCT system |
| CN112155510A (en) * | 2020-09-30 | 2021-01-01 | 广东唯仁医疗科技有限公司 | Portable adaptive optics OCTA imaging system based on middle numerical aperture |
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Patent Citations (5)
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| CN201019719Y (en) * | 2007-03-29 | 2008-02-13 | 浙江大学 | Spectrum region OCT endoscopic image pick-up device used for in situ optical biopsy |
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