CN109699963A - A kind of pharmaceutical composition - Google Patents
A kind of pharmaceutical composition Download PDFInfo
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- CN109699963A CN109699963A CN201811499708.0A CN201811499708A CN109699963A CN 109699963 A CN109699963 A CN 109699963A CN 201811499708 A CN201811499708 A CN 201811499708A CN 109699963 A CN109699963 A CN 109699963A
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- powder
- pharmaceutical composition
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- capsule
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Abstract
The invention belongs to biomedicine fields, more particularly to a kind of pharmaceutical composition, the pharmaceutical composition contains raw material and Fruit powder rich in selenium, further the pharmaceutical composition include: plant selenoprotein powder, selenium-rich Hairy Bittercress powder, it is a kind of with one of Acerola cherry fruit powder, grapefruit powder, seabuckthorn fruit powder, sweet orange powder, blueberry powder in Se-enriched yeast, research shows that, Acerola cherry fruit powder, grapefruit powder, seabuckthorn fruit powder, sweet orange powder, blueberry powder can promote the absorption of selenium, pharmaceutical composition of the invention has better pharmacological action.
Description
Technical field
The invention belongs to field of pharmaceutical biology, and in particular to a kind of pharmaceutical composition is further selenium-rich raw material and contain
There is the pharmaceutical composition of ascorbic plant.
Background technique
Sweden chemist Berezhus in 1817 has found a kind of new element when roasting chalcopyrite Sulphuric acid, rear to name
For selenium.Selenium content in the earth's crust is quite few, and abundance is only the 7 × 10 of earth crustal mass-5%, and distributed pole is uneven.But selenium
It is the essential microelement of human body, is the component of a variety of enzymes or activated centre in body, there is important physiology
Function and extensive pharmacological action.Selenium deficiency can cause a variety of diseases in body.Suitable selenium can prevent and cure diseases, delay senescence,
Enhance body immunity, various heavy damage caused by body can be resisted.Therefore selenium is the weight with life-type enterprise
Element is wanted, utilization that should be scientific and reasonable.
Recent studies indicate that people can obtain appropriate selenium element needed for human health by eating selenium-enriched food.
Therefore, miscellaneous selenium-enriched food such as selenium-rich rice, Se rich tea, selenium-rich corn powder, Se-rich wheat etc. floods the market, to meet
People's demand growing to selenium-enriched food.
In conclusion studying more selenium-enriched foods, is conducive to consumer and more selects.
Summary of the invention
For these reasons, applicant passes through multiple creative research, obtains a kind of new pharmaceutical composition, the composition
Raw material and Fruit powder including being rich in selenium, further the pharmaceutical composition includes: plant selenoprotein powder, selenium-rich Hairy Bittercress powder, richness
One kind and one of Acerola cherry fruit powder, grapefruit powder, seabuckthorn fruit powder, sweet orange powder, blueberry powder or a variety of, research table in selenium yeast
Bright, Acerola cherry fruit powder, grapefruit powder, seabuckthorn fruit powder, sweet orange powder, blueberry powder can promote the absorption of selenium, pharmaceutical composition of the invention
Object has better pharmacological action.
The invention belongs to medicine bioengineering or food technology fields, and in particular to a kind of pharmaceutical composition is further rich
Selenium raw material and the pharmaceutical composition for containing ascorbic plant.
What the present invention was achieved through the following technical solutions.
A kind of pharmaceutical composition, the pharmaceutical composition include: raw material and Fruit powder rich in selenium.
Wherein the raw material rich in selenium includes plant selenoprotein powder, selenium-rich Hairy Bittercress powder or Se-enriched yeast.
The Fruit powder includes Acerola cherry fruit powder, grapefruit powder, seabuckthorn fruit powder, sweet orange powder or blueberry powder.
Wherein the weight ratio of the raw material in pharmaceutical composition rich in selenium and Fruit powder is 1:0.10-0.70.
Described pharmaceutical composition is prepared into pharmaceutical preparation or food.
Its pharmaceutical formulations includes tablet, capsule, oral solution.
Wherein food includes tablet, capsule, oral solution, pressed candy, solid beverage, effervescent tablet.
The Fruit powder includes Acerola cherry fruit powder, grapefruit powder, seabuckthorn fruit powder, sweet orange powder, blueberry powder, wherein containing effectively at
Divide vitamin C.
The extract source of the present invention of table 1
Fruit powder of the present invention is to specifically include that Acerola cherry fruit containing the ascorbic Fruit powder of effective component
Powder, grapefruit powder, seabuckthorn fruit powder, sweet orange powder, blueberry powder.
Specific embodiment
Below the technical scheme of the invention is illustrated by a specific example, but the scope of the present invention is not limited thereto.
Content described in this specification embodiment is only enumerating to the way of realization of inventive concept, protection of the invention
Range should not be construed as being limited to the specific forms stated in the embodiments, and protection scope of the present invention is also and in art technology
Personnel conceive according to the present invention it is conceivable that equivalent technologies mean.Although embodiment of the invention below is retouched
It states, but the invention is not limited to above-mentioned specific embodiments and applications field, following specific embodiments is only to show
It is meaning property, guiding, rather than it is restrictive.Those skilled in the art under the enlightenment of this specification and are not taking off
In the case where the range protected from the claims in the present invention, a variety of forms can also be made, these belong to the present invention
The column of protection.
The following tests of the present invention are on the basis of multiple creative test, with the claimed technical solution of the present invention
Based on, the conclusive test of the research staff of summary.
Test 1: absorption test research
Test 1 group: selenium-rich Hairy Bittercress powder 10g；
Test 2 groups: selenium-rich Hairy Bittercress powder 10g, Acerola cherry fruit powder 4.5g；
Test 3 groups: selenium-rich Hairy Bittercress powder 10g, grapefruit powder 4.5g；
Test 4 groups: selenium-rich Hairy Bittercress powder 10g, seabuckthorn fruit powder 4.5g；
Test 5 groups: selenium-rich Hairy Bittercress powder 10g, sweet orange powder 4.5g；
Test 6 groups: selenium-rich Hairy Bittercress powder 10g, blueberry powder 4.5g；
It prepares sample solution: taking above-mentioned solution, add water 1000ml, stirring and dissolving is complete；
Test method: one night of fasting before testing, the male SD rat of weight 200g or so, weighing, intraperitoneal injection 20%
Urethane (dosage is that 100g weight injects 0.7ml), after anesthesia and is fixed.Abdominal cavity (about 3 centimeter length) is opened along ventrimeson.
An osculum is respectively cut off from duodenal cap and ileum lower part, it is each to be inserted into the glass tube that diameter is 0.5cm, it is tightened with line, so
Rat is connected in series in circulator afterwards, is rinsed well small intestine contents with 37 DEG C of physiological saline.Take 100ml test liquid
(100ml contains test group) is added in the flask of circulator.Peristaltic pump is started, is recycled 10 minutes with the flow velocity of 2.5ml/min.From
It is zero-time sample that 1.0ml (1ml is directly used in detection) is sampled in flask, and samples that (1ml is each after adding solution 3 hours thereafter
It is a), while solution is added, Se content in flask is measured, to measure selenium in small intestine absorptivity.
Detect Se content method: You Shenyao (Xianghe) Science and Technology Ltd. completes, according to document " Wu Shaoxiong, Yang Shihua, poplar
Light space waits trace elements of selenium [J] food and fermentation work in solid phase extraction concentration _ high effective liquid chromatography for measuring rhodiola
Industry, 2005,31 (7): 107-109. ".
Test result: 2 are shown in Table.
2 different tests group of table absorbs result
Conclusion (of pressure testing): it is above-mentioned experiments have shown that, selenium-rich raw material is used alone, small intestine absorptivity is lower, and when selenium-rich raw material point
Not with Acerola cherry fruit powder, grapefruit powder, seabuckthorn fruit powder, sweet orange powder or blueberry powder, it can be good at the absorption for promoting selenium in small intestine.
Test 2
Improve immunity test
Trial drug:
Test 1 group: selenium-rich Hairy Bittercress powder 10g；
Test 2 groups: selenium-rich Hairy Bittercress powder 10g, grapefruit powder 4.5g；
Test method: BALB/C male mice, weight 18-20g.Mouse 40 are taken, 4 groups is grouped as at random, mouse is made
Mould is hypoimmunity, normal to organize not modeling, and modeling successfully starts to be administered, and control group gives physiological saline 0.2ml/20g.Administration
1-2 group gastric infusion, dosage 30mg/kg, successive administration 30 days, 24 hours broken end sacrificed by exsanguination mouse after drug withdrawal, sterile
Under the conditions of take out spleen, splenocyte suspension is made with 1640 culture medium (contain 10% calf serum), mouse boosting cell is adjusted to 5
×106Cell/ml is added in 96 well culture plates, every 100 μ l of hole, and each hole adds double, and (i.e. one plus ConA, one is not added
ConA).20 μ l of ConA (concentration is 1000 μ g/ml), 80 μ l of 1640 culture medium is every hole to 200 μ l volumes, in 5%CO237
Culture 72 hours in DEG C insulating box, terminate first 24 hours of culture, every hole adds 3H-TdR3.7 × 109(iucr).Use cell harvestor
(TITERTEK CELL HARVESTER550) collects cell in 49 type glass fiber filter papers, successively uses distilled water, 5% triamine
Acetic acid, dehydrated alcohol washing, filter paper is placed in 60 DEG C of incubators and is dried, is added in the cup of the scintillation solution containing 5ml, through liquid scintillation instrument
(BECKMEN LS 9800) survey participates in radioactive activity (cpm), then calculates stimulus index (SI), i.e. the hole ConA is added in SI=
The hole ConA cpm is not added by cpm/.
Influence of 3 different pharmaceutical of table to hypoimmunity mice Splenic vein hemodynamics.
| Group | SI |
| Normal group | 0.717±0.056** |
| Control group | 0.147±0.014 |
| Test 1 group | 0.684±0.093** |
| Test 2 groups | 2.754±0.478**# |
* * p < 0.01 compared with the control group, the #p < 0.05 compared with 1 group of drug
Conclusion (of pressure testing): above-mentioned raising immunity test shows to significantly improve after selenium-rich raw material is combined with Fruit powder
Immunity absolutely proves that the present invention has scientific meaning.
Prepare embodiment
Embodiment 1
Pharmaceutical composition: plant selenoprotein powder 100g, Acerola cherry fruit powder 10g；
Aforementioned pharmaceutical compositions are prepared into tablet, capsule, oral solution；
Aforementioned pharmaceutical compositions are prepared into food, including tablet, capsule, oral solution, pressed candy, solid beverage, effervesce
Piece.
Embodiment 2
Pharmaceutical composition: plant selenoprotein powder 100g, Acerola cherry fruit powder 15g；
Aforementioned pharmaceutical compositions are prepared into tablet, capsule, oral solution；
Aforementioned pharmaceutical compositions are prepared into food, including tablet, capsule, oral solution, pressed candy, solid beverage, effervesce
Piece.
Embodiment 3
Pharmaceutical composition: plant selenoprotein powder 100g, Acerola cherry fruit powder 75g；
Aforementioned pharmaceutical compositions are prepared into tablet, capsule, oral solution；
Aforementioned pharmaceutical compositions are prepared into food, including tablet, capsule, oral solution, pressed candy, solid beverage, effervesce
Piece.
Embodiment 4
Pharmaceutical composition: plant selenoprotein powder 100g, grapefruit powder 20g；
Aforementioned pharmaceutical compositions are prepared into tablet, capsule, oral solution；
Aforementioned pharmaceutical compositions are prepared into food, including tablet, capsule, oral solution, pressed candy, solid beverage, effervesce
Piece.
Embodiment 5
Pharmaceutical composition: plant selenoprotein powder 100g, grapefruit powder 55g；
Aforementioned pharmaceutical compositions are prepared into tablet, capsule, oral solution；
Aforementioned pharmaceutical compositions are prepared into food, including tablet, capsule, oral solution, pressed candy, solid beverage, effervesce
Piece.
Embodiment 6
Pharmaceutical composition: plant selenoprotein powder 100g, grapefruit powder 65g；
Aforementioned pharmaceutical compositions are prepared into tablet, capsule, oral solution；
Aforementioned pharmaceutical compositions are prepared into food, including tablet, capsule, oral solution, pressed candy, solid beverage, effervesce
Piece.
Embodiment 7
Pharmaceutical composition: Se-enriched yeast 100g, sweet orange powder 15g；
Aforementioned pharmaceutical compositions are prepared into tablet, capsule, oral solution；
Aforementioned pharmaceutical compositions are prepared into food, including tablet, capsule, oral solution, pressed candy, solid beverage, effervesce
Piece.
Embodiment 8
Pharmaceutical composition: Se-enriched yeast 100g, sweet orange powder 45g；
Aforementioned pharmaceutical compositions are prepared into tablet, capsule, oral solution；
Aforementioned pharmaceutical compositions are prepared into food, including tablet, capsule, oral solution, pressed candy, solid beverage, effervesce
Piece.
Embodiment 9
Pharmaceutical composition: Se-enriched yeast 100g, sweet orange powder 75g；
Aforementioned pharmaceutical compositions are prepared into tablet, capsule, oral solution；
Aforementioned pharmaceutical compositions are prepared into food, including tablet, capsule, oral solution, pressed candy, solid beverage, effervesce
Piece.
Embodiment 10
Pharmaceutical composition: Se-enriched yeast 100g, blueberry powder 15g；
Aforementioned pharmaceutical compositions are prepared into tablet, capsule, oral solution；
Aforementioned pharmaceutical compositions are prepared into food, including tablet, capsule, oral solution, pressed candy, solid beverage, effervesce
Piece.
Embodiment 11
Pharmaceutical composition: Se-enriched yeast 100g, blueberry powder 40g；
Aforementioned pharmaceutical compositions are prepared into tablet, capsule, oral solution；
Aforementioned pharmaceutical compositions are prepared into food, including tablet, capsule, oral solution, pressed candy, solid beverage, effervesce
Piece.
Embodiment 12
Pharmaceutical composition: Se-enriched yeast 100g, blueberry powder 60g；
Aforementioned pharmaceutical compositions are prepared into tablet, capsule, oral solution；
Aforementioned pharmaceutical compositions are prepared into food, including tablet, capsule, oral solution, pressed candy, solid beverage, effervesce
Piece.
Embodiment 13
Pharmaceutical composition: Se-enriched yeast 100g, blueberry powder 75g；
Aforementioned pharmaceutical compositions are prepared into tablet, capsule, oral solution；
Aforementioned pharmaceutical compositions are prepared into food, including tablet, capsule, oral solution, pressed candy, solid beverage, effervesce
Piece.
Claims (7)
1. a kind of pharmaceutical composition, it is characterised in that the pharmaceutical composition includes: raw material and Fruit powder rich in selenium.
2. a kind of pharmaceutical composition according to claim 1, wherein the raw material rich in selenium includes plant selenoprotein powder, selenium-rich
Hairy Bittercress powder or Se-enriched yeast.
3. a kind of pharmaceutical composition according to claim 1, wherein Fruit powder includes Acerola cherry fruit powder, grapefruit powder, sand
Spine powder, sweet orange powder or blueberry powder.
4. a kind of pharmaceutical composition according to claim 1 is wherein rich in the raw material and Fruit powder of selenium in pharmaceutical composition
Weight ratio be 1:0.10-0.70.
5. a kind of pharmaceutical composition according to claim 1-4, it is characterised in that pharmaceutical composition prepares patent medicine
Object preparation or food.
6. a kind of pharmaceutical composition according to claim 5, pharmaceutical formulations include tablet, capsule, oral solution.
7. a kind of pharmaceutical composition according to claim 5, wherein food includes tablet, capsule, oral solution, pressed candy
Fruit, solid beverage, effervescent tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811499708.0A CN109699963A (en) | 2018-12-09 | 2018-12-09 | A kind of pharmaceutical composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811499708.0A CN109699963A (en) | 2018-12-09 | 2018-12-09 | A kind of pharmaceutical composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109699963A true CN109699963A (en) | 2019-05-03 |
Family
ID=66255521
Family Applications (1)
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|---|---|---|---|
| CN201811499708.0A Pending CN109699963A (en) | 2018-12-09 | 2018-12-09 | A kind of pharmaceutical composition |
Country Status (1)
| Country | Link |
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| CN (1) | CN109699963A (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101133892A (en) * | 2007-10-19 | 2008-03-05 | 海通食品集团股份有限公司 | Method of producing selenium-rich instant fruit powder |
| CN105360757A (en) * | 2014-08-14 | 2016-03-02 | 恩施盛硒生物工程有限公司 | Selenium-rich fruit and vegetable tablets and preparing method thereof |
| CN106035958A (en) * | 2016-06-24 | 2016-10-26 | 恩施德源健康科技发展有限公司 | Fermented selenium-enriched fruit and vegetable plant pressed candies and processing method thereof |
| CN106666743A (en) * | 2016-12-29 | 2017-05-17 | 恩施硒域传奇健康管理有限公司 | Eyestrain-relieving selenium-rich food |
| CN106666715A (en) * | 2016-12-29 | 2017-05-17 | 恩施硒域传奇健康管理有限公司 | Selenium-enriched nutrition formula food capable of enhancing immunity |
| CN107981245A (en) * | 2017-12-11 | 2018-05-04 | 丹阳市茂园果业专业合作社 | A kind of selenium-rich water fruit powder and preparation method thereof |
| CN107981148A (en) * | 2017-12-11 | 2018-05-04 | 丹阳市三木果业有限公司 | A kind of selenium-rich dragon fruit electuary |
| CN108013399A (en) * | 2017-12-11 | 2018-05-11 | 丹阳市三木果业有限公司 | A kind of selenium rich kiwi fruit electuary powder |
| CN108686037A (en) * | 2018-08-08 | 2018-10-23 | 北京硒哥硒生物科技有限公司 | A kind of pharmaceutical composition of protection eyesight |
-
2018
- 2018-12-09 CN CN201811499708.0A patent/CN109699963A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101133892A (en) * | 2007-10-19 | 2008-03-05 | 海通食品集团股份有限公司 | Method of producing selenium-rich instant fruit powder |
| CN105360757A (en) * | 2014-08-14 | 2016-03-02 | 恩施盛硒生物工程有限公司 | Selenium-rich fruit and vegetable tablets and preparing method thereof |
| CN106035958A (en) * | 2016-06-24 | 2016-10-26 | 恩施德源健康科技发展有限公司 | Fermented selenium-enriched fruit and vegetable plant pressed candies and processing method thereof |
| CN106666743A (en) * | 2016-12-29 | 2017-05-17 | 恩施硒域传奇健康管理有限公司 | Eyestrain-relieving selenium-rich food |
| CN106666715A (en) * | 2016-12-29 | 2017-05-17 | 恩施硒域传奇健康管理有限公司 | Selenium-enriched nutrition formula food capable of enhancing immunity |
| CN107981245A (en) * | 2017-12-11 | 2018-05-04 | 丹阳市茂园果业专业合作社 | A kind of selenium-rich water fruit powder and preparation method thereof |
| CN107981148A (en) * | 2017-12-11 | 2018-05-04 | 丹阳市三木果业有限公司 | A kind of selenium-rich dragon fruit electuary |
| CN108013399A (en) * | 2017-12-11 | 2018-05-11 | 丹阳市三木果业有限公司 | A kind of selenium rich kiwi fruit electuary powder |
| CN108686037A (en) * | 2018-08-08 | 2018-10-23 | 北京硒哥硒生物科技有限公司 | A kind of pharmaceutical composition of protection eyesight |
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Application publication date: 20190503 |
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