CN109692201A - A kind of Externally-applied Zhuang medicine composition for treating spermatorrhea and strong drug paste application and preparation method thereof - Google Patents

A kind of Externally-applied Zhuang medicine composition for treating spermatorrhea and strong drug paste application and preparation method thereof Download PDF

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CN109692201A
CN109692201A CN201811632623.5A CN201811632623A CN109692201A CN 109692201 A CN109692201 A CN 109692201A CN 201811632623 A CN201811632623 A CN 201811632623A CN 109692201 A CN109692201 A CN 109692201A
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strong drug
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drug composition
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何晓微
黄欣
尹星
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Guangxi University of Chinese Medicine
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/57Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives

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Abstract

The present invention provides a kind of Externally-applied Zhuang medicine compositions for treating spermatorrhea, belong to curing emission technical field, the strong drug composition includes the raw material of following parts by weight: 0.5~2 part of mountain spill, 0.5~2 part of gekko, 0.5~2 part of black chicken meat, 0.5~2 part of Balsamiferou Blumea Herb and 0.5~2 part of charcoal Selaginella tamariscina;The granularity of the strong drug composition is 18~35 mesh.Strong drug composition of the invention can play the double action of drug absorption and acupoint stimulation, have good curing emission effect.By clinical verification, the strong drug paste application that strong drug composition of the invention is prepared can significantly reduce the ejaculation frequency of spermatorrhea patient, improve symptom.And application treatment is carried out compared with oral diaethyl stilbestroli tablet using strong drug paste application of the invention, can preferably maintain curative effect, ejaculation frequency is reduced and still ensures that the curative effect of Most patients after January of being discontinued.

Description

A kind of Externally-applied Zhuang medicine composition for treating spermatorrhea and strong drug paste application and preparation method thereof
Technical field
The present invention relates to curing emission technical field more particularly to a kind of Externally-applied Zhuang medicine composition for treating spermatorrhea and strengthen Drug paste application and preparation method thereof.
Background technique
Spermatorrhea refers to that man is begun from puberty, in the case where non-sexual intercourse or non-masturbation, the phenomenon that sperm discharge occurs. 1~3 spermatorrhea can monthly occur for normal person between twenty and fifty man, without uncomfortable, referred to as physiological spermatorrhea;If monthly more than 4 It is secondary, and with symptoms such as dizziness, pain in the loins, perineum distending pains, then it is pathological seminal emission.Occur in sleep, referred to as nocturnal emission;Occur When awake, referred to as spermatorrhoea.Pathological seminal emission can influence the quality of life quality, and serious person can influence normal interpersonal friendship It is past, so that patient psychological disorder is occurred.The pathogenic factor of spermatorrhea is more, and pathomechanism is complicated.Cause spermatorrhea Producing reason main There are organic, psychological, mixed type three classes.Apparatus factors can be because of the infection of reproductive organs inflammation, myeleterosis, tumour or mistake Early frequently sexual intercourse etc. induces;Psychological factors are since addiction publication, video etc. induce mostly;Combination is organic and the heart Rationality collective effect causes.
The spermatorrhea of western medicine treatment at present still lacks highly effective means of prevention, and hormone therapy and operative treatment are without bright Aobvious therapeutic effect.
Summary of the invention
The purpose of the present invention is to provide a kind of Externally-applied Zhuang medicine composition for treating spermatorrhea and strong drug paste application and its preparations Method, the topical composition can play the double action of drug absorption and acupoint stimulation, have good curing emission effect Fruit.
In order to achieve the above-mentioned object of the invention, the present invention the following technical schemes are provided:
The present invention provides a kind of Externally-applied Zhuang medicine composition for treating spermatorrhea, the raw materials including following parts by weight: mountain spill 0.5~2 part, 0.5~2 part of gekko, 0.5~2 part of black chicken meat, 0.5~2 part of Balsamiferou Blumea Herb and 0.5~2 part of charcoal Selaginella tamariscina;It is described strong The granularity of drug composition is 18~35 mesh.
Preferably, the strong drug composition includes the raw material of following parts by weight: 1~1.5 part of mountain spill, gekko 1~1.5 Part, 1~1.5 part of black chicken meat, 1~1.5 part of Balsamiferou Blumea Herb and 1~1.5 part of charcoal Selaginella tamariscina.
Preferably, the granularity of the strong drug composition is 20~30 mesh.
The present invention provides described in above scheme strengthen drug composition preparation method, steps are as follows: by mountain spill, gekko, Black chicken meat, Balsamiferou Blumea Herb and the mixing of charcoal Selaginella tamariscina, crush, sterilization, obtain strong drug composition.
Preferably, the temperature of the sterilization is 95~105 DEG C;The time of the sterilization is 8~12min.
The present invention provides a kind of strong drug paste application for treating spermatorrhea, and the strong drug paste application includes described in above scheme Strong drug composition, water and gauze.
The present invention provides the preparation methods that drug paste application is strengthened described in above scheme, comprising the following steps:
1) strong drug composition described in above scheme and water are mixed, obtains paste;
2) the step 1) paste is applied on gauze, obtains strong drug paste application.
Preferably, the temperature of the water is 40~50 DEG C;The volume ratio of the strong drug composition and water be 1~3:0.5~ 1.5。
Preferably, the smearing thickness of the paste is 2~3mm.
Preferably, the size of the gauze is 13~17cm × 13~17cm.
Beneficial effects of the present invention: the present invention provides a kind of Externally-applied Zhuang medicine composition for treating spermatorrhea, including it is following heavy Measure the raw material of part: 0.5~2 part of mountain spill, 0.5~2 part of gekko, 0.5~2 part of black chicken meat, 0.5~2 part of Balsamiferou Blumea Herb and charcoal volume 0.5~2 part of cypress;The granularity of the strong drug composition is 18~35 mesh.According to strong medical knowledge opinion " Your Majesty side ", " main female side ", " male Mother shares " combination principle, we press its performance, effect, are divided into main ingredient, public medicine, side medicine three classes.Main ingredient has been primary treatment The drug of effect, the monarch drug in a prescription and ministerial drug being equivalent in traditional Chinese medicine;Public medicine refers to that nature and flavor are warmmer, to treat one based on asthenia cold syndrome Class medicine;Female medicine refers to that nature and flavor are relatively cold, to treat a kind of medicine based on heat symptom-complex;Side medicine is the medicine for assisting main ingredient to generate therapeutic efficiency Object, the ministerial drug or adjutant being equivalent in traditional Chinese medicine.All medicines are used in combination, and the qi-restoratives that can detoxify, QI invigorating shield kidney, controlling nocturnal emission with astringent drugs are only lost, and reach To the purpose for the treatment of spermatorrhea.In the present invention, mountain spill all has the symptoms such as spermatorrhoea, nocturnal emission good as main ingredient, controlling nocturnal emission with astringent drugs arresting seminal emission Good therapeutic effect.Gekko is as public medicine, warming kidney and enhancing yang, treats kidney yang virtual loss and the spermatorrhea that causes.Black chicken meat is used as female medicine, Nourishing kidney yin treats the deficiency of the kidney yin and the spermatorrhea that causes.Gekko and black chicken meat male and female are arranged in pairs or groups, and tonifying both YIN and YANG treats yin-yang two Empty, the unconsolidation of the kidney-qi the spermatorrhea.Balsamiferou Blumea Herb improves asthenia after spermatorrhea, waist acid as side medicine, relaxing tendons and activating collaterals, tonneau tendon and vessel The symptoms such as soft.For charcoal Selaginella tamariscina as side medicine, nature and flavor are gentle, and flat tonifying yin sun, controlling nocturnal emission with astringent drugs is only lost, remaining drug is assisted to play shield kidney arresting seminal emission The effect of.Strong drug composition of the present invention has effects that protect kidney, controlling nocturnal emission with astringent drugs, only lose, and can preferably improve the disease of spermatorrhea patient Shape improves the quality of life of patient, is a kind of good medicine for treating spermatorrhea.By clinical verification, strong drug composition system of the invention Standby obtained strong drug paste application can significantly reduce the ejaculation frequency of spermatorrhea patient, improve symptom.And it is strengthened using of the invention Drug paste application carries out application treatment compared with oral diaethyl stilbestroli tablet, can preferably maintain curative effect, reduces ejaculation frequency, is stopping After medicine January, the curative effect of Most patients is still ensured that.
Specific embodiment
The present invention provides a kind of Externally-applied Zhuang medicine composition for treating spermatorrhea, the raw materials including following parts by weight: mountain spill 0.5~2 part, 0.5~2 part of gekko, 0.5~2 part of black chicken meat, 0.5~2 part of Balsamiferou Blumea Herb and 0.5~2 part of charcoal Selaginella tamariscina;It is described strong The granularity of drug composition is 18~35 mesh, preferably 20~30 mesh, more preferably 22~25 mesh;In the present invention, the strong medicine group The raw material for closing object is preferably provided by Guangxi University of Chinese Medicine's the first affiliated hospital central pharmacy.
The present invention be arranged the granularity of traditional Chinese medicine powder be 18~35 purposes the reason is that, the traditional Chinese medicine powder of above-mentioned granularity be added water into Relatively good paste can be formed when row mixing, can persistently be attached to patient's waist when carrying out application treatment to patient. If particle is too big, stable paste cannot be formed;And particle is too small then can cost of idleness.
In the present invention, the strong drug composition includes 0.5~2 part of mountain spill, preferably 1~1.5 part;It harvests on the mountain Son is sweet, and puckery, mild-natured, as main ingredient, controlling nocturnal emission with astringent drugs arresting seminal emission all has good therapeutic effect to symptoms such as spermatorrhoea, nocturnal emissions.
In the present invention, the strong drug composition includes 0.5~2 part of gekko, preferably 1~1.5 part;The gekko is salty, Mild-natured, as public medicine, warming kidney and enhancing yang treats kidney yang virtual loss and the spermatorrhea that causes.
In the present invention, the strong drug composition includes 0.5~2 part of black chicken meat, preferably 1~1.5 part;The crow Bone chicken is sweet, mild-natured, and as female medicine, nourishing kidney yin treats the deficiency of the kidney yin and the spermatorrhea that causes.
In the present invention, the strong drug composition includes 0.5~2 part of Balsamiferou Blumea Herb, preferably 1~1.5 part;The strong wind Ai Xin, hardship, it is warm-natured, as side medicine, the symptoms such as relaxing tendons and activating collaterals, tonneau tendon and vessel improve asthenia after spermatorrhea, and waist is aching and limp.
In the present invention, the strong drug composition includes 0.5~2 part of charcoal Selaginella tamariscina, preferably 1~1.5 part;The charcoal volume Bai Xin, mild-natured, as side medicine, nature and flavor are gentle, and flat tonifying yin sun, controlling nocturnal emission with astringent drugs is only lost, remaining drug is assisted to play the function of shield kidney arresting seminal emission Effect.
In the present invention, mountain spill all has good treatment to symptoms such as spermatorrhoea, nocturnal emissions as main ingredient, controlling nocturnal emission with astringent drugs arresting seminal emission Effect.Gekko is as public medicine, warming kidney and enhancing yang, treats kidney yang virtual loss and the spermatorrhea that causes.The female medicine of black chicken meat conduct, nourishing kidney yin, The spermatorrhea treating the deficiency of the kidney yin and causing.Gekko and black chicken meat male and female are arranged in pairs or groups, and tonifying both YIN and YANG treats the yin-yang deficiency, unconsolidation of the kidney-qi Spermatorrhea.The symptoms such as Balsamiferou Blumea Herb, which is used as, helps medicine, relaxing tendons and activating collaterals, tonneau tendon and vessel, asthenia after improvement spermatorrhea, and waist is aching and limp.Charcoal The effect of for Selaginella tamariscina as side medicine, nature and flavor are gentle, flat tonifying yin sun, controlling nocturnal emission with astringent drugs is only lost, remaining drug is assisted to play shield kidney arresting seminal emission.
The present invention provides described in above scheme strengthen drug composition preparation method, steps are as follows: by mountain spill, gekko, Black chicken meat, Balsamiferou Blumea Herb and the mixing of charcoal Selaginella tamariscina, crush, sterilization, obtain strong drug composition;The time of the crushing is preferably 10 ~60s, more preferably 30s;The present invention is not particularly limited the temperature of the crushing;The equipment of the crushing be preferably in The bright medicinal herb grinder of medicine disintegrator, the more preferably rising sun, specification HK-02A;The temperature of the sterilization is preferably 95~105 DEG C, more Preferably 100 DEG C;The time of the sterilization is preferably 8~12min, more preferably 10min.
The present invention provides a kind of strong drug paste application for treating spermatorrhea, and the strong drug paste application includes described in above scheme Strong drug composition, water and gauze;The volume ratio of the strong drug composition and water is preferably 1~3:0.5~1.5, more preferably 2:1.In the present invention, the water is mixed into paste as solvent and traditional Chinese medicine powder, forms external patch application, does not add other auxiliary materials It can reach and good stick effect.
The present invention provides the preparation methods that drug paste application is strengthened described in above scheme, comprising the following steps:
1) strong drug composition described in above scheme and water are mixed, obtains paste;
2) the step 1) paste is applied on gauze, obtains strong drug paste application.
In the present invention, strong drug composition described in above scheme and water are mixed, paste is obtained;The present invention is to described Mixed time, mode, temperature are not particularly limited;The temperature of the water is preferably 40~50 DEG C, and more preferably 45 DEG C.This The temperature of invention setting water is conducive to strong drug composition for 40~50 DEG C and forms stable paste and will not influence drug effect, in addition, 40 ~50 DEG C of condition can make patient feel comfortable.
The paste is applied on gauze by the present invention after obtaining paste, obtains strong drug paste application;It is described strong The smearing thickness of drug composition is preferably 2~3mm;The gauze is preferably sized to 13~17cm × 13~17cm, more preferably For 15cm × 15cm;The number of plies of the gauze is preferably 1~2 layer;The gauze is preferably medical absorbent cotton/gauze.
The present invention provides the application methods that drug paste application is strengthened described in above scheme, and steps are as follows: the strong drug paste is applied Agent is pasted on the waist of patient;The strong drug paste application is preferably current existing system;The strong drug paste application is preferably pasted on trouble The waist of person is more preferably sticked in the 1st spinous process of lumbar vertebra to the 5th entire waist of spinous process of lumbar vertebra;Every dose of strong drug paste application Sticking number is preferably 1 time;Each application time is preferably 20~50min, more preferably 30~40min.
In the present invention, the strong drug paste application can stimulate the urinary bladder channel of foot-Taiyang, positioned at the Sanjiaoshu, shen shu, gas of waist Xuanshu in waist of extra large Yu and governor vessel, the gate of vitality.
A kind of Externally-applied Zhuang medicine composition for treating spermatorrhea and strong drug paste are provided to provided by the invention below with reference to embodiment Application and preparation method thereof is described in detail, but they cannot be interpreted as limiting the scope of the present invention.
A kind of Externally-applied Zhuang medicine composition for treating spermatorrhea of embodiment 1
1. raw material: mountain spill 100g, gekko 100g, black chicken meat 100g, Balsamiferou Blumea Herb 100g and charcoal Selaginella tamariscina 100g, it is above Chinese medicine is provided by Guangxi University of Chinese Medicine's the first affiliated hospital central pharmacy.
2. preparation method
Mountain spill, gekko, black chicken meat, Balsamiferou Blumea Herb and charcoal Selaginella tamariscina are through the bright medicinal herb grinder of the rising sun (model: HK-02A) difference It crushes about half a minute, granularity is 20 mesh, obtains strong drug composition.
A kind of strong drug paste application for treating spermatorrhea of embodiment 2
1) ratio for being 2:1 according to the volume ratio of strong drug composition and water, by the strong drug composition of embodiment 1 and 40~ 50 DEG C of warm water are mixed and made into paste, obtain paste.
2) the step 1) paste is uniformly applied on 1 layer of gauze that specification is 15cm × 15cm, smearing thickness is 3mm, the strong drug paste application for the spermatorrhea that obtains medical treatment.
Embodiment 3 verifies the therapeutic effect of the strong drug paste application of embodiment 2
It goes to a doctor in andrology, the first affiliated hospital, Guangxi University of Chinese Medicine, is advised by " tcm clinical practice practice guidelines (the 3rd edition) " It is fixed, it chooses and nocturnal emission monthly occurs within 30~40 years old or spermatorrhoea reaches patient totally 42 of 4 times or more.Be randomly divided into stick group and Diethylstilbestrol group, every group of 21 people.
Case selection
Selection meets the patient of spermatorrhea diagnostic criteria in 2013 editions " tcm clinical practice practice guidelines (the 3rd editions) ".Exclude mark It is quasi-: 1. not meet spermatorrhea diagnostic criteria person;2. still in the patient of adolescence;3. merge intentionally, liver, kidney and hemopoietic system, The serious conditions persons such as disorderly system, tumour are immunized;4. loner, or being associated with spiritual, neuropathy can not the person of cooperation;5. to this Drug allergy person;6. once being treated in the recent period using similar drugs, related or phase antagonism drug was such as taken, drug is caused Curative effect is difficult to judge;7. it is all not by regulation medication, can not judge curative effect or data it is not congruent affect the treatment or safety judgement Person.
Therapeutic scheme
It sticks the strong medicine waist of group use to stick, key agents: 1 part of mountain spill, 1 part of gekko, 1 part of black chicken meat, Balsamiferou Blumea Herb 1 part, 1 part of charcoal Selaginella tamariscina.Warm water reconciles into paste, daily waist application treatment 30min, and continuous 1 month.
Diethylstilbestrol group takes orally diaethyl stilbestroli tablet, GuangDong HuaNan Pharmacy Group Co., Ltd's production, import drugs registration certificate Number: H44024916, specification: 1mg/100 piece/box.3 times a day, each 2mg, continuous 1 month.
Observation index
Efficacy determination mark is formulated according to " the new Chinese medicine guideline of clinical investigations " of State Administration of Traditional Chinese Medicine's publication It is quasi-:
1. recovery from illness: spermatorrhea completely disappears, the symptoms such as no dizziness, insomnia, aching pain in waist and back, private parts distending pain.
2. effectively: spermatorrhea number is reduced to monthly 3 times and hereinafter, the symptoms such as dizziness, insomnia, aching pain in waist and back, private parts distending pain It disappears or is obviously improved.
3. invalid: spermatorrhea number is without change, still with symptoms or symptoms such as dizziness, insomnia, aching pain in waist and back, private parts distending pains Improve unobvious.
As a result
After treatment 1 month, all patient's curative effect situation numbers (being shown in Table 1).Two groups through examining, result difference has statistics It learns meaning (P < 0.05), illustrates two groups of patients after treatment in 1 month, it is female that the effect of application treatment is better than oral ethylene Phenol, application treatment can preferably reduce the ejaculation frequency of spermatorrhea patient, improve symptom.
1 two groups of patient's curative effect situation numbers of table
After being discontinued 1 month, patient passes out semen situation number (being shown in Table 2).Two groups through examining, result difference is statistically significant (P < 0.05) illustrates two groups of patients after being discontinued 1 month, and application treatment can be tieed up preferably compared with oral diaethyl stilbestroli tablet Curative effect is held, ejaculation frequency is reduced and still ensures that the curative effect of Most patients after January of being discontinued.
Spermatorrhea situation number after table 2 is discontinued 1 month
As seen from the above embodiment, the present invention provides a kind of strong drug paste application for treating spermatorrhea, the strong drug paste application The ejaculation frequency of spermatorrhea patient can be significantly reduced, symptom is improved, and can be good at maintaining curative effect.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications It should be regarded as protection scope of the present invention.

Claims (10)

1. a kind of Externally-applied Zhuang medicine composition for treating spermatorrhea, the raw material including following parts by weight: 0.5~2 part of mountain spill, gekko 0.5~2 part, 0.5~2 part of black chicken meat, 0.5~2 part of Balsamiferou Blumea Herb and 0.5~2 part of charcoal Selaginella tamariscina;The granularity of the strong drug composition For 18~35 mesh.
2. strong drug composition according to claim 1, which is characterized in that the strong drug composition includes following parts by weight Raw material: 1~1.5 part of mountain spill, 1~1.5 part of gekko, 1~1.5 part of black chicken meat, 1~1.5 part of Balsamiferou Blumea Herb and charcoal Selaginella tamariscina 1~ 1.5 part.
3. strong drug composition according to claim 1 or 2, which is characterized in that the granularity of the strong drug composition be 20~ 30 mesh.
4. strengthening the preparation method of drug composition described in claims 1 to 3 any one, steps are as follows: by mountain spill, gekko, crow Bone chicken, Balsamiferou Blumea Herb and the mixing of charcoal Selaginella tamariscina, crush, sterilization, obtain strong drug composition.
5. the preparation method according to claim 4, which is characterized in that the temperature of the sterilization is 95~105 DEG C;It is described to kill The time of bacterium is 8~12min.
6. a kind of strong drug paste application for treating spermatorrhea, which is characterized in that the strong drug paste application includes that claims 1 to 3 is any Strong drug composition, water and gauze described in one.
7. strengthening the preparation method of drug paste application described in claim 6, comprising the following steps:
1) strong drug composition described in claims 1 to 3 any one and water are mixed, obtains paste;
2) the step 1) paste is applied on gauze, obtains strong drug paste application.
8. preparation method according to claim 7, which is characterized in that the temperature of the water is 40~50 DEG C;The strong medicine The volume ratio of composition and water is 1~3:0.5~1.5.
9. preparation method according to claim 8, which is characterized in that the smearing thickness of the paste is 2~3mm.
10. preparation method according to claim 8 or claim 9, which is characterized in that the size of the gauze is 13~17cm × 13 ~17cm.
CN201811632623.5A 2018-12-29 2018-12-29 A kind of Externally-applied Zhuang medicine composition for treating spermatorrhea and strong drug paste application and preparation method thereof Withdrawn CN109692201A (en)

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Application publication date: 20190430