CN109689646B - 用于治疗疼痛的氘代化合物 - Google Patents

用于治疗疼痛的氘代化合物 Download PDF

Info

Publication number
CN109689646B
CN109689646B CN201780041032.8A CN201780041032A CN109689646B CN 109689646 B CN109689646 B CN 109689646B CN 201780041032 A CN201780041032 A CN 201780041032A CN 109689646 B CN109689646 B CN 109689646B
Authority
CN
China
Prior art keywords
pain
solution
oxaspiro
compound
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201780041032.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN109689646A (zh
Inventor
黄超然
程昌富
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NeuForm Pharmaceuticals Inc
Original Assignee
NeuForm Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NeuForm Pharmaceuticals Inc filed Critical NeuForm Pharmaceuticals Inc
Publication of CN109689646A publication Critical patent/CN109689646A/zh
Application granted granted Critical
Publication of CN109689646B publication Critical patent/CN109689646B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780041032.8A 2016-07-01 2017-06-30 用于治疗疼痛的氘代化合物 Active CN109689646B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662357396P 2016-07-01 2016-07-01
US62/357,396 2016-07-01
PCT/US2017/040519 WO2018006077A1 (en) 2016-07-01 2017-06-30 Deuterated compounds for treating pain

Publications (2)

Publication Number Publication Date
CN109689646A CN109689646A (zh) 2019-04-26
CN109689646B true CN109689646B (zh) 2022-09-02

Family

ID=60787696

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780041032.8A Active CN109689646B (zh) 2016-07-01 2017-06-30 用于治疗疼痛的氘代化合物

Country Status (7)

Country Link
US (1) US20200330444A1 (enExample)
EP (1) EP3472155B1 (enExample)
JP (1) JP6889186B2 (enExample)
CN (1) CN109689646B (enExample)
AU (1) AU2017290897B2 (enExample)
CA (1) CA3029768C (enExample)
WO (1) WO2018006077A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116075505A (zh) * 2021-08-31 2023-05-05 天地恒一制药股份有限公司 阿片受体激动剂及其制备方法和用途
CN118638109B (zh) * 2024-04-30 2025-10-28 中山大学 一种阿片类药物-奥赛利定的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012129495A1 (en) * 2011-03-23 2012-09-27 Trevena, Inc. Opioid receptor ligands and methods of using and making same
CN105037371A (zh) * 2015-06-30 2015-11-11 西华大学 一种氘代的吲哚胺-2,3-双加氧酶抑制剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017105881A1 (en) * 2015-12-15 2017-06-22 NeuForm Pharmaceuticals, Inc. Deuterated compounds for treating pain

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012129495A1 (en) * 2011-03-23 2012-09-27 Trevena, Inc. Opioid receptor ligands and methods of using and making same
CN105037371A (zh) * 2015-06-30 2015-11-11 西华大学 一种氘代的吲哚胺-2,3-双加氧酶抑制剂

Also Published As

Publication number Publication date
AU2017290897B2 (en) 2020-05-14
US20200330444A1 (en) 2020-10-22
EP3472155A4 (en) 2019-04-24
WO2018006077A1 (en) 2018-01-04
CA3029768C (en) 2022-05-17
JP2019519561A (ja) 2019-07-11
EP3472155B1 (en) 2022-03-16
EP3472155A1 (en) 2019-04-24
AU2017290897A1 (en) 2019-01-24
CN109689646A (zh) 2019-04-26
CA3029768A1 (en) 2018-01-04
JP6889186B2 (ja) 2021-06-18

Similar Documents

Publication Publication Date Title
AU2017245125B2 (en) Heterocyclic compound
EP1260512B1 (en) Novel cyclic amide derivatives
EP3292116B1 (en) 3-aryl-4-amido-bicyclic [4,5,0]hydroxamic acids as hdac inhibitors
AU2025203295A1 (en) Substituted macrocyclic compounds and related methods of treatment
JP6653319B2 (ja) 複素環化合物
US9884844B2 (en) Heterocyclic compounds and methods of use thereof
CN108779102B (zh) 用于治疗癌症及相关疾病和病况的氘代化合物及其组合物和方法
CN103917534B (zh) 作为h3受体抑制剂的包含哌啶和哌嗪环的氨基甲酸酯/脲衍生物
CN116003393A (zh) 作为glp-1受体激动剂的化合物及其用途
US8778958B2 (en) Synthesis of metabolically stable agents for alcohol and drug abuse
TWI851890B (zh) 抗病毒性1,3-二氧代茚化合物
CN112707892A (zh) 哒嗪酮或哒嗪类化合物及其衍生物和药物组合物
WO2025016432A1 (zh) 具有抗kras突变肿瘤活性的化合物
CN109689646B (zh) 用于治疗疼痛的氘代化合物
CN104583210A (zh) 杂芳基化合物及其使用方法
WO2017105881A1 (en) Deuterated compounds for treating pain
US12390472B2 (en) Polysubstituted benzene compound and preparation method and use thereof
CN117447385A (zh) 氘代的3-氨甲基-4-苯基哌啶-4-醇类化合物的制备及其用途
WO2023190665A1 (ja) モルヒナン誘導体及びその医薬用途
CN107501270A (zh) 一种含有磺酰吖丙啶结构的化合物、药物组合物以及其应用
HK40060541B (zh) 可用於治疗医学病症的新型吗啡喃
WO2025174540A1 (en) Novel morphine framework derivatives
WO2015064573A1 (ja) オピオイド鎮痛剤
CN120787225A (zh) 新型麦角林类和治疗心境障碍的方法
HK1163676A1 (en) Bicyclic heterocyclic compound

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant