CN109689212A - 用于使含微粒的流体流聚焦的微流控芯片 - Google Patents

用于使含微粒的流体流聚焦的微流控芯片 Download PDF

Info

Publication number
CN109689212A
CN109689212A CN201780038037.5A CN201780038037A CN109689212A CN 109689212 A CN109689212 A CN 109689212A CN 201780038037 A CN201780038037 A CN 201780038037A CN 109689212 A CN109689212 A CN 109689212A
Authority
CN
China
Prior art keywords
particle
microfluidic channel
fluid
channel
micro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780038037.5A
Other languages
English (en)
Chinese (zh)
Inventor
D·卡沙宁
I·什韦茨
F·迪科拉托
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Serlix Co Ltd
Original Assignee
Serlix Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serlix Co Ltd filed Critical Serlix Co Ltd
Publication of CN109689212A publication Critical patent/CN109689212A/zh
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0463—Hydrodynamic forces, venturi nozzles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0469—Buoyancy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0038—Investigating nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0042—Investigating dispersion of solids
    • G01N2015/0053—Investigating dispersion of solids in liquids, e.g. trouble
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1402—Data analysis by thresholding or gating operations performed on the acquired signals or stored data
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1413—Hydrodynamic focussing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Fluid Mechanics (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CN201780038037.5A 2016-04-20 2017-04-20 用于使含微粒的流体流聚焦的微流控芯片 Pending CN109689212A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16166177.2 2016-04-20
EP16166177 2016-04-20
PCT/EP2017/059453 WO2017182599A1 (en) 2016-04-20 2017-04-20 A microfluidic chip for focussing a stream of particulate containing fluid

Publications (1)

Publication Number Publication Date
CN109689212A true CN109689212A (zh) 2019-04-26

Family

ID=55794906

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780038037.5A Pending CN109689212A (zh) 2016-04-20 2017-04-20 用于使含微粒的流体流聚焦的微流控芯片

Country Status (10)

Country Link
US (1) US11633737B2 (https=)
EP (1) EP3445492B1 (https=)
JP (1) JP2019518971A (https=)
CN (1) CN109689212A (https=)
AU (1) AU2017251990A1 (https=)
BR (1) BR112018071562A2 (https=)
CA (1) CA3021609A1 (https=)
MX (1) MX2018012862A (https=)
RU (1) RU2018136932A (https=)
WO (1) WO2017182599A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111135882A (zh) * 2019-12-30 2020-05-12 南方科技大学 一种二维流动聚焦装置
CN112698024A (zh) * 2020-12-08 2021-04-23 华中农业大学 一种基于差分阻抗颗粒计数的免疫分析方法
CN114112826A (zh) * 2021-11-25 2022-03-01 天津大学 用于荧光微粒的声光互联微流控检测系统和检测方法
CN120082423A (zh) * 2025-05-06 2025-06-03 杭州谱康医学科技有限公司 微粒分选装置和方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3556845A1 (en) 2018-04-20 2019-10-23 Cellix Limited A method and device for transfecting cells
WO2020201206A1 (en) 2019-03-29 2020-10-08 Cellix Limited A method and device for transfecting cells
CA3097579A1 (en) 2019-10-28 2021-04-28 Op-Hygiene Ip Gmbh Method of identifying biologic particles
EP3871773B1 (en) 2020-02-27 2025-12-10 Cellix Limited A method of determining the transfection status of a plurality of cells
US20230408395A1 (en) * 2020-11-20 2023-12-21 The Trustees Of Princeton University System and method for pneumatic-free electronically driven microfluidics to allow massive scalability with integrated cellular and biomolecular detection
WO2022197253A1 (en) * 2021-03-18 2022-09-22 Nanyang Technological University Method for label-free cell activation profiling using microfluidic impedance cytometry
WO2023150581A1 (en) * 2022-02-02 2023-08-10 Oregon Health & Science University Methods and systems for sorting particles in fluids
EP4465016A4 (en) * 2022-03-14 2025-11-26 Orange Biomed Co Ltd METHOD FOR MEASURING PARTICLES IN SOLUTION AND DEVICE FOR ITS IMPLEMENTATION

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080093306A1 (en) * 2002-02-04 2008-04-24 Colorado School Of Mines Cell sorting device and method of manufacturing the same
US20120063664A1 (en) * 2010-09-14 2012-03-15 Dino Di Carlo Inertial particle focusing flow cytometer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US6437551B1 (en) * 1999-11-02 2002-08-20 The Regents Of The University Of California Microfabricated AC impedance sensor
JP4093740B2 (ja) 2001-09-27 2008-06-04 独立行政法人科学技術振興機構 微粒子分別マイクロチップと微粒子分別装置
US6703819B2 (en) * 2001-12-03 2004-03-09 Board Of Regents, The University Of Texas System Particle impedance sensor
GB2383127B (en) * 2001-12-12 2004-10-20 Proimmune Ltd Device and method for investigating analytes in liquid suspension or solution
DE102007017318B4 (de) 2007-04-11 2014-07-31 Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Technologie, dieses vertreten durch den Präsidenten der Physikalisch-Technischen Bundesanstalt Verfahren zum hydrodynamischen Fokussieren eines Fluidstroms und Anordnung
JP4661942B2 (ja) 2008-05-13 2011-03-30 ソニー株式会社 マイクロチップとその流路構造
US9170138B2 (en) * 2010-10-01 2015-10-27 The Board Of Trustees Of The Leland Stanford Junior University Enhanced microfluidic electromagnetic measurements

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080093306A1 (en) * 2002-02-04 2008-04-24 Colorado School Of Mines Cell sorting device and method of manufacturing the same
US20120063664A1 (en) * 2010-09-14 2012-03-15 Dino Di Carlo Inertial particle focusing flow cytometer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CLAUDIO CUPELLI ET AL: "Leukocyte enrichment based on a modified pinched flow fractionation approach", 《MICROFLUIDICS AND NANOFLUDICS》 *
HAMED AMINI: "Fluid-Particle and Fluid-structure Interactions in Inertial Microfluidics", 《ELECTTRONIC THESIS AND DISSERTATIONS》 *
TAO SUN ET AL: "Single-cell microfluidic impedance cytometry:a review", 《MICROFLUIDICS AND NANOFLUIDICS ,SPRINGER ,BERLIN,DE》 *
UNYOUNG KIM ET AL: "Simultaneous sorting of multiple bacterial targets using integrated Dielectrophoretic-Magnetic Activated Cell Sorter", 《LAB ON A CHIP》 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111135882A (zh) * 2019-12-30 2020-05-12 南方科技大学 一种二维流动聚焦装置
CN111135882B (zh) * 2019-12-30 2021-07-09 南方科技大学 一种二维流动聚焦装置
CN112698024A (zh) * 2020-12-08 2021-04-23 华中农业大学 一种基于差分阻抗颗粒计数的免疫分析方法
CN112698024B (zh) * 2020-12-08 2022-04-26 华中农业大学 一种基于差分阻抗颗粒计数的免疫分析方法
CN114112826A (zh) * 2021-11-25 2022-03-01 天津大学 用于荧光微粒的声光互联微流控检测系统和检测方法
CN114112826B (zh) * 2021-11-25 2024-04-19 天津大学 用于荧光微粒的声光互联微流控检测系统和检测方法
CN120082423A (zh) * 2025-05-06 2025-06-03 杭州谱康医学科技有限公司 微粒分选装置和方法

Also Published As

Publication number Publication date
EP3445492A1 (en) 2019-02-27
AU2017251990A1 (en) 2018-11-15
CA3021609A1 (en) 2017-10-26
BR112018071562A2 (pt) 2019-02-12
RU2018136932A (ru) 2020-05-20
MX2018012862A (es) 2019-07-04
US20190232290A1 (en) 2019-08-01
WO2017182599A1 (en) 2017-10-26
US11633737B2 (en) 2023-04-25
EP3445492B1 (en) 2021-09-15
JP2019518971A (ja) 2019-07-04
RU2018136932A3 (https=) 2020-09-07

Similar Documents

Publication Publication Date Title
CN109689212A (zh) 用于使含微粒的流体流聚焦的微流控芯片
US11839876B2 (en) Apparatus for microfluidic flow cytometry analysis of a particulate containing fluid
KR100746431B1 (ko) 셀 소터 칩
US10359349B2 (en) Use of focused light scattering techniques in biological applications
JP5901582B2 (ja) 粒子を集束するための方法及び装置
Yun et al. Cell manipulation in microfluidics
US9023294B2 (en) Cell analyzer
JP3949056B2 (ja) スプリット集中サイトメーター
US20020127144A1 (en) Device for analyzing particles and method of use
CN105848793B (zh) 材料选择性的递送至细胞
US20210331169A1 (en) Microfluidic apparatus for separation of particulates in a fluid
Tang et al. Asymmetric serpentine microchannel based impedance cytometer enabling consistent transit and accurate characterization of tumor cells and blood cells
AU2011326516A1 (en) Counting particles using an electrical differential counter
EP2268789A2 (en) Systems and methods for counting cells and biomolecules
CN109863398B (zh) 用于检测和/或表征肿瘤细胞的方法及相关装置
EP3418721A1 (en) A microfluidic chip
Righetto et al. Integrating impedance cytometry with other microfluidic tools towards multifunctional single-cell analysis platforms
JP2017523399A (ja) 付勢化サンプル注入フローセル
US20190346555A1 (en) Use of focused light scattering techniques in biological applications
Morgan et al. Microfluidic impedance cytometry for blood cell analysis
Noreldin et al. Isolation and characterization of extracellular vesicles: Classical and modern approaches
Hou et al. Advances in Single Cell Impedance Cytometry for Biomedical Applications
Noreldin et al. and Modern Approaches
Raji et al. Effect of Channel Geometry and Flow Rates in Hydrodynamic Focusing on Impedance Detection of Circulating Tumor Cells
Peng Impedance Flow Cytometry for Single-Cell Analysis in Position-Based Microfluidic Cell Sorting

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20190426