A kind of production method and production system of corncob glycosyl medical carrier
Technical field
The invention belongs to field of medicaments, and in particular to a kind of production method of corncob glycosyl medical carrier and production system
System.
Background technique
Corncob is the cob that corn ear sloughs seed, accounts for 20%-the 30% of corn ear weight, institutional framework is divided into
Three parts: the 1. crude part in corncob surface layer, i.e. bran chaff layer or bran chaff outer layer.2. position among corncob, hard and flexible, claim
For corncob wooden body or intermediate wooden body layer, account for the 60% of corncob gross mass.3. corncob innermost end soft section, soft
And pure white, referred to as corncob sponge batt layer, also known as corncob stem, sponge core, internal sponge core.Wherein bran chaff and sponge
Body portion accounts for about the 40% of corncob total amount.
The aqueous deal of corncob glycosyl carrier is 5.0%, crude protein quantity 5.7%, crude fibre amount are 3.7%, and specific gravity is
0.3-0.35, adsorption capacity 50-70 are the high-quality carriers for making veterinary drug, are the ideal substitutes of beancake powder and other carriers.It is beautiful
Rice core glycosyl carrier has many advantages, such as that even tissue, hardness is suitable for, good toughness, water imbibition is strong, wear-resisting property is good, in use process
In it is non-breakable, can be used as feed pre-mixing material, mixing methionine, lysine, lysine proteins powder, glycine betaine, mould inhibitor, dimension life
The veterinary additives product such as element, phosphatide, phytase, flavouring agent and Madumycin, apramycin choline chloride, production trophism carry
Body.Corncob glycosyl carrier has the spies such as, long shelf-life more at low cost than other carriers, good fluidity, water imbibition are strong, palatability is good
Point.
Corncob generally uses beating type or slice type method to carry out crushing and processing in the prior art.Due to corncob tissue
Structure belongs to spongy tissue structure, processes corn cob granule using beating type method, corn cob granule surface spongy tissue can become
Must be hard, absorption speed is slow, and granular size diversity ratio is larger, and mostly at 0.1-0.8 centimetres, particle is excessive to be unfavorable for moisture absorption;
It is processed into corn cob granule using slice type mode, particle is haggled over uniformly, and granularity difference with regard to smaller, beat by absorption speed ratio
Formula faster, but processing cost be higher than beating type.
Such as application No. is 201410813018.3 Chinese invention patent applications to disclose a kind of manufacturing process of fish meal:
Use rice bran, corncob as feed vector, dregs of beans, rapeseed meal, cotton dregs and peanut meal constitutive protein matter content through extruding, which is added, is
27 ~ 30% single protein raw material;85% is crushed to by 60-80 mesh;2% corn protein powder and 2.5% blood meal is added;
Quenched 120 seconds at 90-95 DEG C;By the compression forming of 1:11 ~ 12, the process costs are low, nutritional sufficiency, degradation noxious material, pollute
It is small.
Such as application No. is 200910136138.3 Chinese invention patent applications to disclose a kind of corn core carrier modifying side
Method, this method, which includes the following steps: 1) to input corn core carrier in heater, to be heated, and heating temperature is 20 DEG C -25 DEG C;2) exist
The ammonium hydrogen carbonate of the food-grade of the parts by weight of addition 2.5%-4.0% obtains mixed material, will prepare as additive in corncob
Mixed material be input in mixing machine and be mixed, mixing time is 10-20 minutes;3) it is mixed evenly
Material inputs gas-tight silo storage, and the time that material store in gas-tight silo is 8-12 hours, makes that the pH value of corn core carrier is quenched to be
6.8-7.2.This method is simple, can effectively carry out to corn core carrier quenched, makes that the pH value of corn core carrier is quenched to be
6.8-7.2。
The above-mentioned prior art can not distinguish each section of corncob, but corncob is integrally processed, institute
The product technology quality index obtained is lower, cannot fully meet the requirement as veterinary drug glycosyl carrier.
Application No. is 201710229596.6 Chinese invention patent applications to disclose a kind of preparation of corncob granule powder
Method, first the bran chaff outer layer of removing corncob and the sponge core of inside, obtain wooden body, then crush to corncob,
Finally obtain that there are multiple efficacies so that mixed liquor fully penetrates into the wooden body of corncob using transformation preparation method
Corncob granule powder.By the way that the plant extraction liquid containing Multiple components is added in the preparation process of corncob granule powder, effectively
The pH value for having adjusted corncob itself, and the effect of also have both plant extraction liquid in granular powder, so that corn cob granule is made
Powder is more favorable for the carrier as feed, veterinary drug etc., while particle is uniform, good toughness, neither too hard, nor too soft.This prior art passes through
By plant mixed extract, it is added in wooden body, improves the drug effect of corncob, but it does not disclose that how to remove outside bran chaff
Layer and the sponge core of inside.
Application No. is 201510642119.3 Chinese invention patent application disclose one kind can significantly less staff,
The corn cob granule selection by winnowing de-burring machine for improving separative efficiency, improving disintegrate-quality, reducing ambient contamination degree, including it is primary
The sieve plate I and sieve plate II being tilted to the left is respectively set in separator box and secondary separation case in first separation case and secondary separation case,
It is located at below sieve plate I in first separation bottom face and is equipped with particle outlet I, is located at below sieve plate II in secondary separation bottom face and is equipped with
Particle outlet II, and impurity removal port is equipped between sieve plate II and particle outlet II in secondary separation bottom face, it is set in impurity removal port
Oriented right-oblique sieve plate III, the particle outlet I are connect by connecting tube with particle entrance II, and the wheat bran outlet I passes through
Connecting tube connects once cyclone, and the wheat bran outlet II is connected with secondary cyclone by connecting tube, in the impurity removal port
Lower section is provided with vibrating screen.The above-mentioned prior art is by the way of wind-force and particle self gravity, it is therefore intended that realize wheat bran with
The separation of other corn cob fractions, it does not disclose that how to separate corncob wooden body with internal sponge core.
In conclusion needing the production method and system of a kind of corncob glycosyl medical carrier, product technology quality is improved
Index meets the requirement as veterinary drug glycosyl carrier.
Summary of the invention
To solve the above-mentioned problems in the prior art, the purpose of the present invention is to provide a kind of corncob glycosyl medicine
The production method of carrier can isolate wooden body from corncob entirety, be made good fluidity, strong adsorption force, can be complete
Degradation, the high-quality glycosyl carrier that pH value is suitble to, palatability is good;Another object of the present invention is to provide a kind of production system,
It can isolate wooden body from corncob entirety, have the characteristics that high production efficiency.
To achieve the above object, a kind of the technical solution adopted by the present invention are as follows: producer of corncob glycosyl medical carrier
Method includes the following steps:
Step 1: roller crushing: by corncob entirely through double roller crushing;
Step 2: after roller crushing, corncob coarse crushing: is subjected to coarse crushing entirely through pulverizer;
Step 3: vibration screening: after coarse crushing, corncob being screened entirely through vibrating screen, after removing on-the-sieve material, is received
Collect undersize material;
Step 4: micro mist: screenings further progress is crushed;
Step 5: quenched;
Step 6: it is granulated.
Optimization, during roller crushing, double roller relative rotation, double roller quantity be 20-30 pairs, roller gap on to
Under from 30-40mm be gradually decrease to 15-10mm.
Optimization, during vibration screening, shaker vibration frequency is 4-10 times/second, and sieve pore is 20-30 mesh.
Optimization, in micro mist step, screenings further progress is crushed to 60-80 mesh.
Optimization, the concrete operations of quenched step are as follows: corncob micro mist is inputted in heater and is heated, heating temperature is
26-28 DEG C, the food grade ammonium bicarbonate of 3.5%-5% is added according to weight, is then sufficiently mixed, material placement 6 hours, most
Finished product pH value is 6.8-7.3.
Optimization, the concrete operations of granulation step are as follows: maize cob meal is passed through steam, humidity is adjusted to 8-12%, then
By ring moulds pelletizer, it is 10-30 mesh after granulation that using ring moulds and pressure roller compression moulding, ring moulds compression ratio, which is 5,.
Optimization, including sequentially connected double roller, Roughpulverizer, vibrating screen, slimer.
Optimization, double roller relative rotation, double roller quantity be 20-30 pairs, roller gap from top to bottom from 30-40mm gradually
It is decreased to 15-10mm.
The beneficial effects of the present invention are:
1. the present invention successively carries out roller crushing, coarse crushing, the mode for shaking screening by using to corncob is whole, from jade
Wooden body is isolated in rice core entirety, the bran chaff outer layer of adsorption capacity difference in corncob and internal sponge core are effectively removed;Into
One step by micro mist, it is quenched, be granulated, be finally made good fluidity, strong adsorption force, can degradable, pH value be suitble to,
The good high-quality glycosyl carrier of palatability.
2. in roller crushing step of the present invention, by double roll-in, and double roller relative rotation, double roller quantity is arranged
15-10mm is gradually decrease to from 30-40mm from top to bottom to, roller gap for 20-30, corncob is integrally rolled into multiple big
Then block is gradually rolled into more fritters, realized corncob bran chaff outer layer, wooden body, internal sea after last roll-in substantially
The separation of continuous core, size are remained above 20 mesh.
3., since corncob bran chaff outer layer and internal sponge core density are small, relatively light, crushing cutter can not in coarse crushing process
Put forth effort on bran chaff outer layer and internal sponge core, bran chaff outer layer and internal sponge core can not be effectively broken, only with broken
The cutting and rotation of broken knife and float, roll;And intermediate wooden body layer then because density be broken greatly knife be effectively broken into 50 mesh with
Under.
4. during vibration screening, shaker vibration frequency is 4-10 times/second, sieve pore is 20-30 mesh, corncob bran chaff
Outer layer and internal sponge core particles degree are still greater than 20 mesh therefore can be maintained on sieve, and gradually concentrate with the vibration of sieve, are easy
It collects and removes, intermediate wooden body layer granularity drains under sieve less than 50 mesh by vibration, it is achieved that dividing from corncob entirety
Wooden body is separated out, the adsorptivity of glycosyl carrier is substantially increased.The vibration frequency can satisfy production requirement and will not generate compared with
Big dust, causes environmental pollution.
5. in micro mist step, screenings further progress is crushed to 60-80 mesh, convenient for subsequent quenched, granulation step
Suddenly, the glycosyl carrier of good fluidity is produced.
6. granulation step improves product density, it is readily transported;Quenched step has adjusted product pH value, is conducive to tie up
Protect veterinary drug drug effect, and make its pH value be suitble to, palatability it is good.
7. production system provided by the invention can isolate wood from corncob entirety by the way of mechanical equipment
Plastid, device structure is simple, and whole process does not need hand-sorted, saves manpower, has the characteristics that high production efficiency.
Detailed description of the invention
Fig. 1 is the production system schematic diagram of corncob glycosyl medical carrier provided by the invention;
Fig. 2 is the double roller schematic diagram of production system provided by the invention.
1. double roller;2, Roughpulverizer;3, vibrating screen;4, slimer.
Specific embodiment
The present invention is illustrated below by specific embodiment.
A kind of production method for corncob glycosyl medical carrier that present embodiment uses, includes the following steps:
Step 1: roller crushing: by corncob entirely through double roller crushing, double roller relative rotation, double roller quantity is
20-30 pairs, roller gap is gradually decrease to 15-10mm from 30-40mm from top to bottom;
Step 2: after roller crushing, corncob coarse crushing: is subjected to coarse crushing entirely through pulverizer;
Step 3: vibration screening: after coarse crushing, corncob is screened entirely through vibrating screen, shaker vibration frequency is
4-10 times/second, sieve pore is 20-30 mesh, after removing on-the-sieve material, collects undersize material;
Step 4: micro mist: screenings further progress is crushed, and is crushed to 60-80 mesh;
Step 5: quenched: corncob micro mist being inputted in heater and is heated, heating temperature is 26-28 DEG C, is added according to weight
The food grade ammonium bicarbonate of 3.5%-5%, is then sufficiently mixed, and material is placed 6 hours, and final products pH value is 6.8-7.3;
Step 6: being granulated: maize cob meal being passed through steam, humidity is adjusted to 8-12%, then by ring moulds pelletizer, uses
Ring moulds and pressure roller compression moulding, ring moulds compression ratio are 5, are 10-30 mesh after granulation.
The system that present embodiment produces above-mentioned corncob glycosyl medical carrier, including it is sequentially connected double roller, thick
Pulverizer, vibrating screen, slimer.Double roller relative rotation, double roller quantity are 20-30 pairs, and roller gap is from top to bottom from 30-
40mm is gradually decrease to 15-10mm.
Present embodiment changes the quantity of double roller, gap, shaker vibration frequency, sieve pore, food grade ammonium bicarbonate
The pH value of additive amount, product is provided with 6 embodiments and 5 comparative examples, 11 examples is respectively adopted and disposably handle 50-
100kg corncob, and calculate and have detected corncob wooden body layer recovery rate, the adsorptivity of glycosyl carrier obtained, load beast
Medicine validity period etc., specifically it is shown in Table 1.
Wherein corncob wooden body layer recovery rate calculation are as follows: weigh corncob overall weight, collect and weigh step
Screenings weight in four, the ratio between screenings weight and corncob overall weight are denoted as wooden body layer recovery rate.
The adsorptivity and effect experiment method of corncob glycosyl carrier are as follows: by glycosyl carrier drying to water content less than 5%,
Gross weight is denoted as original weight amount;Veterinary drug aqueous solution is configured, a certain amount of glycosyl carrier and the veterinary drug aqueous solution of 5 times of volumes are premixed, set
In in closed cabin, transformation processing, pressure limit is -50KPa to 140KPa, sufficiently after absorption, is filtered, and dry, weighing is denoted as suction
Attached weight;The ratio of the weight gain and glycosyl carrier original weight amount that calculate glycosyl carrier is denoted as adsorption rate.By the jade after absorption veterinary drug
The accelerated ageing by the way of ultraviolet light irradiation of rice core carrier detects veterinary drug validity period.
Table 1
|
Embodiment 1 |
Embodiment 2 |
Embodiment 3 |
Embodiment 4 |
Embodiment 5 |
Embodiment 6 |
Comparative example 1 |
Comparative example 2 |
Comparative example 3 |
Comparative example 4 |
Comparative example 5 |
The quantity of double roller |
20 |
22 |
24 |
20 |
28 |
30 |
10 |
22 |
30 |
28 |
30 |
Lamellar spacing (mm) on double roller |
40mm |
40mm |
30mm |
30mm |
35mm |
35mm |
20mm |
50mm |
35mm |
35mm |
35mm |
Lamellar spacing (mm) under double roller |
15mm |
10mm |
15mm |
10mm |
15mm |
10mm |
15mm |
5mm |
10mm |
15mm |
10mm |
Vibrating screen sieve pore (mesh) |
20 |
30 |
20 |
30 |
20 |
30 |
20 |
20 |
50 |
20 |
30 |
The additive amount of ammonium hydrogen carbonate |
3.5% |
4% |
5% |
3.5% |
4% |
5% |
3.5% |
4% |
5% |
8% |
2% |
The pH value of product |
6.8 |
7.2 |
7.3 |
6.8 |
7.1 |
7.3 |
6.8 |
7.3 |
7.3 |
8.7 |
6.1 |
Wooden body layer recovery rate |
55% |
50% |
52% |
48% |
56% |
49% |
26% |
34% |
34% |
56% |
49% |
The adsorption rate of glycosyl carrier |
153% |
142% |
164% |
171% |
159% |
160% |
98% |
77% |
80% |
110% |
102% |
It loads veterinary drug validity period (moon) |
12 |
13 |
13 |
12 |
13 |
13 |
12 |
13 |
13 |
7 |
5 |
By compare above it is found that present embodiment provide embodiment wooden body layer recovery rate reach 56%, the suction of glycosyl carrier
Attached rate reaches 171%, and the validity period for loading veterinary drug reaches 13 months.And double roller quantity is super less than 20, upper lamellar spacing in comparative example
Crossing 40mm or being less than 30mm, lower lamellar spacing, less than 30 mesh, causes wooden body layer to receive less than 10mm or more than 15mm, vibration sieve pore
Rate reduces, while because being mixed into bran chaff outer layer and internal sponge core in wooden body layer, so that the adsorptivity of glycosyl carrier reduces;Add
Enter food grade ammonium bicarbonate amount lower than 3.5% or higher than 5%, final products pH value is that can reduce glycosyl lower than 6.8 or higher than 7.3
The validity period of the adsorptivity of carrier and damage load veterinary drug significantly.Therefore the embodiment that present embodiment provides is better than comparative example.