CN109674768A - A kind of composite membrane for treating the concurrent II phase exanthemv of skin-type vasculitis - Google Patents
A kind of composite membrane for treating the concurrent II phase exanthemv of skin-type vasculitis Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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Abstract
The present invention provides a kind of composite membrane for treating the concurrent II phase exanthemv of skin-type vasculitis, which is prepared by reddish tone father-in-law cellulose acetate, chitosan, gelatin, the preparation method comprises the following steps: taking reddish tone father-in-law's medicinal material, steam explosion prepares reddish tone father-in-law's cellulose；Then reddish tone father-in-law's cellulose is prepared into reddish tone father-in-law's cellulose acetate；Reddish tone father-in-law's cellulose acetate is added in chitosan solution, is poured into mold volatilizes solvent after mixing evenly, be prepared into composite membrane；Composite membrane is impregnated in gelatin solution again, takes out drying to get a kind of composite membrane for treating the concurrent II phase exanthemv of skin-type vasculitis.The composite membrane has effects that antibacterial anti-inflammatory, promotes wound healing, additionally it is possible to adsorb wound secretion, biocompatibility is good, can be used for treating the concurrent II phase exanthemv of skin-type vasculitis.
Description
Technical field
The present invention relates to medical instruments fields, and in particular to a kind of skin-type vasculitis concurrent II phase exanthemv for the treatment of
Composite membrane.The composite membrane is prepared by reddish tone father-in-law cellulose acetate, chitosan, gelatin, has antibacterial anti-inflammatory, wound is promoted to be cured
The effect of conjunction, can adsorb wound secretion, and biocompatibility is good, can be used for treating the concurrent II phase skin of skin-type vasculitis
Skin festers.
Background technique
Reddish tone father-in-law is a kind of Chinese medicine, is Acanthaceae Lu Licao platymiscium Lu Licao (Ruellia with all herbal medicine
Drymophila (Diels) Hand.-Mazz.), can clearing heat and detoxicating, swelling and pain relieving, external application can control fracture, knife wound infection, sore
Malicious abscess.
Chitosan is obtained via chitin is deacetylated, have good biocompatibility, can biodegrade, have simultaneously
The effect of antibacterial, anti-inflammatory.Gelatin is to make collagen hydrolysate therein using the skin of mammal, bone, first, angle as raw material and obtain
The natural macromolecular substance arrived is widely used containing there are many amino acid needed by human in medicine, cosmetic field.
Vasculitis is a kind of connective tissue disease, etiology unknown and is easy concurrent exanthemv.Clinic is burst using skin
Ulcer method by stages, is divided into I, II, III, IV phase according to wound color for the concurrent exanthemv of vasculitis.Disease in the II phase
People, wound diffusate start to increase, and skin corium and sub-dermal fat layer have inflammatory reaction, there is stronger tenderness sense.This
To clean based on the surface of a wound, then the clinical necrotic tissue that patient is often removed before the topical application of drug is covered phase wound care with sterile gauze.
However sterile gauze has no therapeutic effect, cannot also exclude the risk of infected wound completely.Therefore, research and development have antibacterial anti-inflammatory function
Effect, nontoxic biomembrane substitute sterile gauze, are not only avoided that the risk of patient's infected wound, but also can play therapeutic effect and add
The rehabilitation of fast patient.
Chitosan has the function of antibacterial, but the biomembrane made of chitosan merely, because intensity not enough to application by
To limitation；Gelatin has good gelation, film forming；Cellulose acetate film, the processing is simple, nontoxic, have excellent elasticity,
Gas permeability and liquified adsorbility.A kind of composite membrane being prepared by chitosan, gelatin, cellulose acetate is researched and developed, then is treatment skin
The ideal material of the concurrent II phase exanthemv of skin type vasculitis.
Summary of the invention
In order to solve foregoing problems, the present invention provides a kind of skin-type vasculitis concurrent II phase exanthemvs for the treatment of
Composite membrane and preparation method thereof.The compound eye mask is prepared by reddish tone father-in-law cellulose acetate, chitosan, gelatin, can be adsorbed
Wound secretion has effects that antibacterial anti-inflammatory, can be promoted wound healing with nutrition wound tissue, can be used for treating skin-type
The concurrent II phase exanthemv of vasculitis.
A kind of composite membrane for treating the concurrent II phase exanthemv of skin-type vasculitis, is prepared by following step:
(1) reddish tone father-in-law's cellulose is prepared；
(2) reddish tone father-in-law's cellulose acetate is prepared；
(3) reddish tone father-in-law cellulose acetate and chitosan complex film are prepared；
(4) composite membrane made from step (3) is soaked in gelatin solution, taken out obtained by drying.
Further, the reddish tone father-in-law cellulose is the preparation method comprises the following steps: take reddish tone father-in-law's herb, cleans and crushes after drying and mistake
100 meshes impregnate 10h with 0.5% sulfuric acid, are washed to neutrality after filtering out sulfuric acid solution, are placed in steam in steam blasting device
Explosion.Then substrate is taken out, according to mass volume ratio 1: the ratio of (10-15) was with deionized water refluxing extraction 2 hours, repeatedly
2 times, water is filtered dry, then with 45% alcohol solution dipping, persistently stirs 2-4h under the conditions of 50-70 DEG C, it is molten then to filter ethyl alcohol
Liquid, which obtains, slightly to be starched, then uses 30%H2O2Bleaching 3h washs products therefrom to neutrality, and grind into powder is spare after freeze-drying.
Further, in reddish tone father-in-law's cellulose preparation process, its condition of steam blasting device is pressure 1MPa, pressure
The time that power maintains is 8min.
Further, in reddish tone father-in-law's cellulose preparation process: reddish tone father-in-law is 1 according to solid-to-liquid ratio with 0.5% sulfuric acid:
(5-15) addition.
Further, the reddish tone father-in-law cellulose acetate is the preparation method comprises the following steps: reddish tone father-in-law's cellulose is added 60 in glacial acetic acid
DEG C water-bath 3h, adds acetic anhydride and 70% concentrated sulfuric acid, and water-bath simultaneously continues to filter after stirring 2h, filtrate is poured into deionized water
Reddish tone father-in-law cellulose acetate is precipitated, reddish tone father-in-law cellulose acetate is collected by filtration and is washed to neutrality, pulverizes after freeze-drying
End is spare.
Further, in reddish tone father-in-law's cellulose acetate preparation process: reddish tone father-in-law cellulose and glacial acetic acid are according to solid
Liquor ratio 1: (10-15) proportion；Reddish tone father-in-law cellulose and acetic anhydride are matched according to solid-to-liquid ratio 1: 10；Acetic anhydride and 70% concentrated sulfuric acid are pressed
It is matched according to volume ratio 200: 1.
Further, the method that the reddish tone father-in-law cellulose acetate and chitosan are prepared into composite membrane are as follows: weigh appropriate
Chitosan is added in 50% acetum, and reddish tone father-in-law cellulose acetate is added after magnetic agitation 4h, continues to stir 2h, then will mix
Conjunction solution, which is poured into mold, volatilizes solvent, is prepared into reddish tone father-in-law cellulose acetate and chitosan complex film.
Further, during the cellulose acetate and chitosan are prepared into composite membrane, chitosan it is deacetylated
Degree is greater than 90%, matches with 50% acetic acid according to solid-to-liquid ratio for 1: 50.
Further, during the cellulose acetate and chitosan are prepared into composite membrane, cellulose acetate is added
Quality be chitosan solution volume 5%-15%.
Further: it is molten that the reddish tone father-in-law cellulose acetate and chitosan complex film that will have been prepared are soaked in 5%-15% gelatin
10min in liquid, after film to be composite fully absorbs, taking-up is placed in 60 DEG C of drying in oven and treats skin-type vasculitis to get a kind of
The composite membrane of concurrent II phase exanthemv.
Beneficial effects of the present invention:
A kind of composite membrane for treating the concurrent II phase exanthemv of skin-type vasculitis of the present invention, the composite membrane is with reddish tone father-in-law
Cellulose acetate, chitosan, gelatin are raw material, and three has complementary advantages, and prepared composite membrane is ventilative, flexible, sense of touch is good,
Can not only antibacterial anti-inflammatory prevent from infecting, and wound liquid body exudate can be adsorbed, nutrition wound tissue promotes Wound healing.
Detailed description of the invention
Fig. 1 is the production technological process of composite membrane of the present invention.
Specific embodiment:
Hereinafter, complete, detailed description will be carried out to technical solution of the present invention in conjunction with specific embodiments.
Embodiment 1
The present invention provides a kind of composite membrane for treating the concurrent II phase exanthemv of skin-type vasculitis, the compound eye mask by
Reddish tone father-in-law cellulose acetate, chitosan, gelatin are prepared, preparation process the following steps are included:
(1) reddish tone father-in-law's cellulose is prepared；
(2) reddish tone father-in-law's cellulose acetate is prepared；
(3) reddish tone father-in-law cellulose acetate and chitosan complex film are prepared；
(4) composite membrane made from step (3) is soaked in gelatin solution, taken out obtained by drying.
The reddish tone father-in-law cellulose is cleaned and crushes and sieve with 100 mesh sieve after drying the preparation method comprises the following steps: take reddish tone father-in-law's herb,
500mL0.5% sulfuric acid immersion 10h is added in medicinal material 100g after weighing reddish tone father-in-law sieving, is washed to neutrality after filtering out sulfuric acid solution,
It is placed in steam blasting in steam blasting device, condition is pressure 1MPa, and the time that pressure maintains is 8min.Then substrate is taken
Out, it is added 1200mL deionized water refluxing extraction 2 hours, 2 times repeatedly, water is filtered dry, then with 45% alcohol solution dipping,
4h is stirred under the conditions of 70 DEG C, is then filtered ethanol solution and is obtained and slightly starch, then uses 30%H2O2Bleaching 3h, products therefrom is washed
To neutrality, grind into powder is spare after freeze-drying.
100mL glacial acetic acid is added the preparation method comprises the following steps: weighing 10g reddish tone father-in-law's cellulose in the reddish tone father-in-law cellulose acetate,
60 DEG C of water-bath 3h, add 100mL acetic anhydride and the 0.5mL70% concentrated sulfuric acid, and water-bath simultaneously continues to filter after stirring 2h, filtrate is fallen
Enter precipitation reddish tone father-in-law cellulose acetate in deionized water, reddish tone father-in-law cellulose acetate is collected by filtration and is washed to neutrality, freezing is dry
Grind into powder is spare after dry.
The reddish tone father-in-law cellulose acetate and chitosan complex film the preparation method comprises the following steps: weighing deacetylation greater than 90%
Chitosan 2g be added 100mL50% acetum in, after magnetic agitation 4h be added reddish tone father-in-law cellulose acetate 5g, continue to stir
Then mixed solution is poured into mold and volatilizes solvent by 2h, be prepared into reddish tone father-in-law cellulose acetate and chitosan complex film.
The reddish tone father-in-law cellulose acetate and chitosan complex film that have prepared are soaked in the gelatin solution that concentration is 5%
Middle 10min, after film to be composite fully absorbs, taking-up is placed in 60 DEG C of drying in oven and treats skin-type vasculitis simultaneously to get a kind of
Send out the composite membrane of II phase exanthemv.
Embodiment 2
The present invention provides a kind of composite membrane for treating the concurrent II phase exanthemv of skin-type vasculitis, the compound eye mask by
Reddish tone father-in-law cellulose acetate, chitosan, gelatin are prepared, preparation process the following steps are included:
(1) reddish tone father-in-law's cellulose is prepared；
(2) reddish tone father-in-law's cellulose acetate is prepared；
(3) reddish tone father-in-law cellulose acetate and chitosan complex film are prepared；
(4) composite membrane made from step (3) is soaked in gelatin solution, taken out obtained by drying.
The reddish tone father-in-law cellulose is cleaned and crushes and sieve with 100 mesh sieve after drying the preparation method comprises the following steps: take reddish tone father-in-law's herb,
It weighs medicinal material 100g after reddish tone father-in-law sieving 1000mL0.5% sulfuric acid is added and impregnate 10h, filter out in being washed to after sulfuric acid solution
Property, it is placed in steam blasting in steam blasting device, condition is pressure 1MPa, and the time that pressure maintains is 8min.Then by substrate
It takes out, is added 1300mL deionized water refluxing extraction 2 hours, 2 times repeatedly, water is filtered dry, then soaked with 45% ethanol solution
Bubble stirs 3h under the conditions of 60 DEG C, then filters ethanol solution and obtains and slightly starch, then uses 30%H2O2Bleaching 3h, products therefrom is washed
It washs to neutrality, grind into powder is spare after freeze-drying.
120mL glacial acetic acid is added the preparation method comprises the following steps: weighing 10g reddish tone father-in-law's cellulose in the reddish tone father-in-law cellulose acetate,
60 DEG C of water-bath 3h, add 100mL acetic anhydride and the 0.5mL70% concentrated sulfuric acid, and water-bath simultaneously continues to filter after stirring 2h, filtrate is fallen
Enter precipitation reddish tone father-in-law cellulose acetate in deionized water, reddish tone father-in-law cellulose acetate is collected by filtration and is washed to neutrality, freezing is dry
Grind into powder after dry；This preparation process is repeated, the reddish tone father-in-law's cellulose acetate for collecting enough components is spare.
The reddish tone father-in-law cellulose acetate and chitosan complex film the preparation method comprises the following steps: weighing deacetylation greater than 90%
Chitosan 2g be added 100mL50% acetum in, after magnetic agitation 4h be added reddish tone father-in-law cellulose acetate 10g, continue to stir
2h is mixed, then mixed solution is poured into mold and volatilizes solvent, is prepared into reddish tone father-in-law cellulose acetate and chitosan complex film.
The reddish tone father-in-law cellulose acetate and chitosan complex film that have prepared are soaked in the gelatin solution that concentration is 10%
Middle 10min, after film to be composite fully absorbs, taking-up is placed in 60 DEG C of drying in oven and treats skin-type vasculitis simultaneously to get a kind of
Send out the composite membrane of II phase exanthemv.
Embodiment 3
The present invention provides a kind of composite membrane for treating the concurrent II phase exanthemv of skin-type vasculitis, the compound eye mask by
Reddish tone father-in-law cellulose acetate, chitosan, gelatin are prepared, preparation process the following steps are included:
(1) reddish tone father-in-law's cellulose is prepared；
(2) reddish tone father-in-law's cellulose acetate is prepared；
(3) reddish tone father-in-law cellulose acetate and chitosan complex film are prepared；
(4) composite membrane made from step (3) is soaked in gelatin solution, taken out obtained by drying.
The reddish tone father-in-law cellulose is cleaned and crushes and sieve with 100 mesh sieve after drying the preparation method comprises the following steps: take reddish tone father-in-law's herb,
It weighs medicinal material 100g after reddish tone father-in-law sieving 1500mL0.5% sulfuric acid is added and impregnate 10h, filter out in being washed to after sulfuric acid solution
Property, it is placed in steam blasting in steam blasting device, condition is pressure 1MPa, and the time that pressure maintains is 8min.Then by substrate
It takes out, is added 1400mL deionized water refluxing extraction 2 hours, 2 times repeatedly, water is filtered dry, then soaked with 45% ethanol solution
Bubble stirs 2h under the conditions of 50 DEG C, then filters ethanol solution and obtains and slightly starch, then uses 30%H2O2Bleaching 3h, products therefrom is washed
It washs to neutrality, grind into powder is spare after freeze-drying.
150mL glacial acetic acid is added the preparation method comprises the following steps: weighing 10g reddish tone father-in-law's cellulose in the reddish tone father-in-law cellulose acetate,
60 DEG C of water-bath 3h, add 100mL acetic anhydride and the 0.5mL70% concentrated sulfuric acid, and water-bath simultaneously continues to filter after stirring 2h, filtrate is fallen
Enter precipitation reddish tone father-in-law cellulose acetate in deionized water, reddish tone father-in-law cellulose acetate is collected by filtration and is washed to neutrality, freezing is dry
Grind into powder after dry；This preparation process is repeated, the reddish tone father-in-law's cellulose acetate for collecting enough components is spare.
The reddish tone father-in-law cellulose acetate and chitosan complex film the preparation method comprises the following steps: weighing deacetylation greater than 90%
Chitosan 2g be added 100mL50% acetum in, after magnetic agitation 4h be added reddish tone father-in-law cellulose acetate 15g, continue to stir
2h is mixed, then mixed solution is poured into mold and volatilizes solvent, is prepared into reddish tone father-in-law cellulose acetate and chitosan complex film.
The reddish tone father-in-law cellulose acetate and chitosan complex film that have prepared are soaked in the gelatin solution that concentration is 15%
Middle 10min, after film to be composite fully absorbs, taking-up is placed in 60 DEG C of drying in oven and treats skin-type vasculitis simultaneously to get a kind of
Send out the composite membrane of II phase exanthemv.
The above, some embodiments only of the invention, but scope of protection of the present invention is not limited thereto, appoints
What those familiar with the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its structure
Think of is subject to equivalent substitution or change, should be covered by the scope of protection of the present invention.
Claims (10)
1. a kind of composite membrane for treating the concurrent II phase exanthemv of skin-type vasculitis, which is characterized in that the composite membrane is by reddish tone
Father-in-law's cellulose acetate, chitosan, gelatin are prepared, and preparation method includes:
(1) reddish tone father-in-law's cellulose is prepared；
(2) reddish tone father-in-law's cellulose acetate is prepared；
(3) reddish tone father-in-law cellulose acetate and chitosan complex film are prepared；
(4) composite membrane made from step (3) is soaked in gelatin solution, takes out and obtained by drying a kind of treats skin-type vasculitis simultaneously
Send out the composite membrane of II phase exanthemv.
2. compound membrane preparation method according to claim 1, which is characterized in that the preparation side of reddish tone father-in-law's cellulose
Method are as follows: take reddish tone father-in-law's herb, clean and crush and sieve with 100 mesh sieve after drying, impregnate 10h with 0.5% sulfuric acid, filter out sulfuric acid solution
After be washed to neutrality, be placed in steam blasting in steam blasting device.Then substrate is taken out, according to mass volume ratio 1: (10-
15) ratio 2 times repeatedly, water was filtered dry with deionized water refluxing extraction 2 hours, then with 45% alcohol solution dipping, 50-
2-4h is persistently stirred under the conditions of 70 DEG C, is then filtered ethanol solution and is obtained and slightly starch, then uses 30%H2O2Bleaching 3h, gained is produced
Object is washed to neutrality, and grind into powder is spare after freeze-drying.
3. compound membrane preparation method according to claim 2, which is characterized in that the steam blasting device, condition
For pressure 1MPa, the time that pressure maintains is 8min.
4. compound membrane preparation method according to claim 2, it is characterised in that: reddish tone father-in-law and 0.5% sulfuric acid are according to solid-liquid
Than being 1: (5-15) addition.
5. compound membrane preparation method according to claim 1, which is characterized in that reddish tone father-in-law's cellulose acetate preparation
Method are as follows: 60 DEG C of water-bath 3h in glacial acetic acid are added in reddish tone father-in-law's cellulose, add acetic anhydride and 70% concentrated sulfuric acid, water-bath is simultaneously held
It is filtered after continuous stirring 2h, filtrate is poured into precipitation reddish tone father-in-law cellulose acetate in deionized water, it is fine that reddish tone father-in-law acetic acid is collected by filtration
Dimension element is simultaneously washed to neutrality, and grind into powder is spare after freeze-drying.
6. compound membrane preparation method according to claim 5, it is characterised in that: reddish tone father-in-law's cellulose acetate preparation
In the process, reddish tone father-in-law cellulose and glacial acetic acid are according to solid-to-liquid ratio 1: (10-15) proportion；Reddish tone father-in-law cellulose and acetic anhydride are according to solid
Liquor ratio 1: 10 matches；Acetic anhydride and 70% concentrated sulfuric acid are matched according to volume ratio 200: 1.
7. compound membrane preparation method according to claim 1, which is characterized in that reddish tone father-in-law cellulose acetate and chitosan system
The standby method at composite membrane are as follows: weigh appropriate chitosan and be added in 50% acetum, reddish tone father-in-law vinegar is added after magnetic agitation 4h
Acid cellulose continues to stir 2h, then mixed solution is poured into mold and volatilizes solvent, is prepared into reddish tone father-in-law's cellulose acetate
And chitosan complex film.
8. compound membrane preparation method according to claim 7, which is characterized in that the deacetylation of chitosan is greater than 90%,
It is matched with 50% acetic acid according to solid-to-liquid ratio for 1: 50.
9. compound membrane preparation method according to claim 7, it is characterised in that: it is poly- for shell that the quality of cellulose acetate is added
The 5%-15% of sugar juice volume.
10. compound eye membrane preparation method according to claim 1, it is characterised in that: the reddish tone father-in-law's acetic acid that will have been prepared
Cellulose and chitosan complex film are soaked in 10min in 5%-15% gelatin solution, and after film to be composite fully absorbs, taking-up is placed in
60 DEG C of drying in oven to get.
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| CN201811462270.9A CN109674768A (en) | 2018-11-26 | 2018-11-26 | A kind of composite membrane for treating the concurrent II phase exanthemv of skin-type vasculitis |
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| CN201811462270.9A CN109674768A (en) | 2018-11-26 | 2018-11-26 | A kind of composite membrane for treating the concurrent II phase exanthemv of skin-type vasculitis |
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| CN104130431A (en) * | 2014-07-06 | 2014-11-05 | 东北林业大学 | Chitosan-furfural residue nano-fiber composite membrane preparation method |
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|---|---|---|---|---|
| CN104130431A (en) * | 2014-07-06 | 2014-11-05 | 东北林业大学 | Chitosan-furfural residue nano-fiber composite membrane preparation method |
| CN105727344A (en) * | 2014-12-10 | 2016-07-06 | 重庆联佰博超医疗器械有限公司 | Composite hemostatic membrane material and preparation method thereof |
| CN106178066A (en) * | 2015-05-07 | 2016-12-07 | 中国科学院化学研究所 | A kind of modified cellulose/chitosan compound hemostatic material and preparation method and application |
| CN105399988A (en) * | 2015-12-12 | 2016-03-16 | 常州大学 | Preparation method for cellulose/chitosan composite modified degradable antibacterial membrane |
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Address after: 510000 Room 101, Room 201, 44 Shuikou Wenxing Street, Tianhe District, Guangzhou City, Guangdong Province Applicant after: Guangzhou Hui Lang non spinning products Co., Ltd. Address before: 510000 Fourth Floor, Building A, 44 Wenxing Street, Shuikou, Yushatan District, Tianhe District, Guangzhou City, Guangdong Province Applicant before: Guangzhou Hui Lang non spinning products Co., Ltd. |
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Address after: 510000 Room 101, Room 201, 44 Shuikou Wenxing Street, Tianhe District, Guangzhou City, Guangdong Province Applicant after: Cosman (Guangzhou) Co.,Ltd. Address before: 510000 Room 101, Room 201, 44 Shuikou Wenxing Street, Tianhe District, Guangzhou City, Guangdong Province Applicant before: GUANGZHOU CDLUNION NON-WOVEN PRODUCTS Co.,Ltd. |
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Application publication date: 20190426 |