CN109673695A - A kind of E Seye sea-buckthorn functional food and preparation method thereof - Google Patents
A kind of E Seye sea-buckthorn functional food and preparation method thereof Download PDFInfo
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- CN109673695A CN109673695A CN201910047846.3A CN201910047846A CN109673695A CN 109673695 A CN109673695 A CN 109673695A CN 201910047846 A CN201910047846 A CN 201910047846A CN 109673695 A CN109673695 A CN 109673695A
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- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
- 229960002855 simvastatin Drugs 0.000 description 1
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
- A21D2/36—Vegetable material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of E Seye sea-buckthorn functional food and preparation method thereof, raw material composition and its content by mass percentage are E Seye 20%~80%, sea-buckthorn 20%~80%, and preparation method is will be after E Seye and sea-buckthorn pretreatment, alcohol reflux is added to extract, gained filtrate merges, recovered ethyl alcohol, the dispersion of medicinal extract hot water, stands, centrifugation, precipitating vacuum drying, is added maltodextrin, softwood processed, granulation, dry, whole grain, total particle to get.The research of the invention finds that by after each taste material combination use, synergistic function has been played, it is hypoglycemic, effect for reducing blood fat is significant.
Description
Technical field
The present invention relates to a kind of functional foods, and in particular to be a kind of E Seye sea-buckthorn functional food and its preparation
Method.
Background technique
With the development and the progress of science and technology of society, people's living standard is continuously improved, and the dietary structure of people is also therewith
It changes, the intake of carbohydrate, protein and fat is continuously increased, and the opposite reduction of amount of exercise, hyperglycemia, hyperlipidemia etc.
The trend constantly risen is presented in metabolic problem, and which exasperates the diseases such as diabetes, atherosclerosis, coronary heart disease, fatty liver
The raising of sick disease incidence.For blood glucose, blood lipid, the two how is controlled in normal level, is to prevent metabolism class disease from further sending out
Exhibition and the key deteriorated.Therefore, effective control blood glucose and blood lipid level, become that people need to pay attention in daily life asks
Topic.
Currently, the treatment for hyperglycemia, hyperlipidemia, mainly takes antidiabetic drug and blood lipid-lowering medicine, such as: diformazan is double
The hypolipidemics such as the antidiabetic drugs such as guanidine, gliclazide, acarbose and Simvastatin, Gemfibrozil.Although these drugs can be
Improve hyperglycemia and hyperlipidemia in short period, but there are patient compliances it is poor, curative effect is low, adverse reaction is more the problems such as, it is sick
People is difficult to take for a long time.It therefore, can be under traditional Chinese medicine theory guidance, by modern means of science and technology, using conventional food
The especially compatibility of " integration of drinking and medicinal herbs " raw material finds suitable functional formulas food, edible by patient's long period, improves
Its blood glucose and blood lipid level become the research and development focus for adjusting blood glucose, blood lipid product.
E Seye is the common integration of drinking and medicinal herbs medicinal material of Tibetan medicine and pharmacology, derives from rosaceous plant Malus toringoides Hughes Malus
The dried leaf of toringoides (Rehd.) Hughes. and tibetan crabapple Malus tiansitoria (Batal.) Schneid..
It is recorded in " Tibetan medicine crystalline substance mirror book on Chinese herbal medicine " and " hiding Chinese voluminous dictionary " earliest, it is cold in nature sweet in flavor, bitter, there is assaulting fortified position product, remove the stagnant, liver protection of greasy paint
Cholagogue and other effects is mainly used for treating indigestion and some liver diseases, and curative for effect, usage is unique.Modern pharmacological research table
It is bright, higher Flavonoids are contained in E Seye, have preferable scavenging capacity to DPPH free radical and hydroxyl radical free radical,
It can also hypoglycemic, antiatherosclerosis, anti-inflammatory.
Sea-buckthorn be Elaeangnaceae plant sea-buckthorn Hippophae rhamnoides L. dry mature fruit, it is warm-natured it is sour,
It is puckery, there is reinforcing spleen to promote digestion, cough-relieving apophlegmatic, promoting blood circulation to remove blood stasis.Sea-buckthorn mainly contains flavones, vitamin, fatty acid, microelement, Asia
The ingredients such as oleic acid, modern pharmacological research discovery, sea-buckthorn have reduction cholesterol, prevent and treat coronary atherosclerosis, antifatigue etc.
Effect.
Summary of the invention
For above situation, for the defect for overcoming the prior art, the object of the present invention is to provide a kind of E Seye sea-buckthorn function
Energy property food and preparation method thereof.
In order to achieve the above-mentioned object of the invention, technical scheme is as follows:
A kind of E Seye sea-buckthorn functional food, using E Seye, sea-buckthorn as primary raw material, each raw material is by mass percentage
Content are as follows: E Seye 20%~80%, sea-buckthorn 20%~80%.
Preferably, which is prepared by following Chinese medicine materials by mass percentage: E Seye 40%
~80%, sea-buckthorn 20%~60%.
The preparation method of the E Seye sea-buckthorn functional food, comprising the following steps:
(1) dry E Seye and sea-buckthorn medicinal material are taken, is crushed, 20 meshes are crossed, is measured according to volume mass than being added 5-10 times
(V/m) 30%-90% ethyl alcohol, refluxing extraction 1-3 times are extracted 1-3 hours every time, and filtration, filtrate merges, in 55-75 DEG C of condition
Under ethyl alcohol is recovered under reduced pressure, obtain medicinal extract；
(2) 3-8 times of amount (m/m) hot water is added in the medicinal extract for obtaining (1), is dispersed with stirring uniformly, places 12-24h；
(3) the medicinal extract liquid 3000-5000rpm/min that (2) dispersion obtains is centrifuged 10-30min, discards supernatant liquid, it is heavy to obtain
It forms sediment, is dried in vacuo under the conditions of 50-70 DEG C, crush, obtain extract powder, it is spare；
(4) it pelletizes: the extract powder that (3) obtain being mixed with the maltodextrin of 1-3 times of mass ratio, softwood processed, pelletized, done
It is dry, whole grain, obtain total particle to get.
Preferably, pulvis, jelly, biscuit, pressed candy is made according to conventional preparation method in the total particle.
The invention has the advantages that: the present invention to be used cooperatively E Seye and sea-buckthorn, has to reduction hyperglycemia, hyperlipidemia aobvious
The synergistic function of work.The present invention experiments have shown that: product of the present invention can reduce the blood glucose level of high glucose and high fat rat model, extensive
The growth of complex weight, improves the Glucose Tolerance of rat model.For the Antioxidant Indexes of rat model, product of the present invention can be mentioned
High SOD in serum, CAT are horizontal, reduce MDA level, enhance endogenous antioxidation system, mitigate response to oxidative stress, alleviate high
The development of blood glucose hyperlipidemia.Product of the present invention can also reduce the blood lipid level of rat model, reduce serum TC, TG, LDL-C contain
Amount improves HDL-C content, has good effect for reducing blood fat to hyperglycemia high blood lipid model.Above-mentioned experimental result also shows, Russia
Color leaf and sea-buckthorn are used cooperatively, have apparent chemiluminescence, above-mentioned drug action be better than E Seye, sea-buckthorn it is independent
It uses.Formula preferred for this invention, is retrieved by domestic and foreign literature, does not find related application, is screened in addition by many experiments,
Gained formula rate is optimum formula ratio, and formula is scientific, and highly-safe, can be used for hyperglycemia, the often feeding of people with hyperlipidemia day
With.
Specific embodiment
Technical solution of the invention is further illustrated combined with specific embodiments below, these embodiments should not be understood as
It is the limitation to technical solution.
Embodiment 1
E Seye 500g, sea-buckthorn 500g
(1) dry E Seye and sea-buckthorn medicinal material are taken, is crushed, 20 meshes are crossed, according to volume mass than 8 times of amount (V/ are added
M) 60% ethyl alcohol refluxing extraction 2 times, extracts 2 hours every time, and filtration, filtrate merges, and ethyl alcohol is recovered under reduced pressure under the conditions of 65 DEG C,
Obtain medicinal extract；
(2) 5 times of amount (m/m) hot water are added in the medicinal extract for obtaining (1), is dispersed with stirring uniformly, places for 24 hours；
(3) the medicinal extract liquid 5000rpm/min that (2) dispersion obtains is centrifuged 20min, discards supernatant liquid, must precipitates, 60 DEG C of items
It is dried in vacuo under part, crushes, obtain extract powder, it is spare；
(4) it pelletizes: the extract powder that (3) obtain being mixed with the maltodextrin of 2 times of mass ratioes, softwood processed, pelletized, it is dry,
Whole grain, obtain total particle to get.
Embodiment 2
E Seye 650g, sea-buckthorn 350g
(1) dry E Seye and sea-buckthorn medicinal material are taken, is crushed, 20 meshes are crossed, according to volume mass than 10 times of amount (V/ are added
M) 90% ethyl alcohol refluxing extraction 1 time, extracts 3 hours every time, and filtration, filtrate merges, and ethyl alcohol is recovered under reduced pressure under the conditions of 75 DEG C,
Obtain medicinal extract；
(2) 8 times of amount (m/m) hot water are added in the medicinal extract for obtaining (1), is dispersed with stirring uniformly, places 12h；
(3) the medicinal extract liquid 3000rpm/min that (2) dispersion obtains is centrifuged 30min, discards supernatant liquid, must precipitates, 70 DEG C of items
It is dried in vacuo under part, crushes, obtain extract powder, it is spare；
(4) it pelletizes: the extract powder that (3) obtain being mixed with the maltodextrin of 3 times of mass ratioes, softwood processed, pelletized, it is dry,
Whole grain, obtain total particle to get.
Embodiment 3
E Seye 800g, sea-buckthorn 200g
(1) dry E Seye and sea-buckthorn medicinal material are taken, is crushed, 20 meshes are crossed, according to volume mass than 6 times of amount (V/ are added
M) 70% ethyl alcohol refluxing extraction 2 times, extracts 1.5 hours every time, and filtration, filtrate merges, and second is recovered under reduced pressure under the conditions of 55 DEG C
Alcohol obtains medicinal extract；
(2) 6 times of amount (m/m) hot water are added in the medicinal extract for obtaining (1), is dispersed with stirring uniformly, places for 24 hours；
(3) the medicinal extract liquid 3500rpm/min that (2) dispersion obtains is centrifuged 15min, discards supernatant liquid, must precipitates, 65 DEG C of items
It is dried in vacuo under part, crushes, obtain extract powder, it is spare；
(4) it pelletizes: the extract powder that (3) obtain being mixed with the maltodextrin of 2 times of mass ratioes, softwood processed, pelletized, it is dry,
Whole grain, obtain total particle to get.
Embodiment 4
E Seye 400g, sea-buckthorn 600g
(1) dry E Seye and sea-buckthorn medicinal material are taken, is crushed, 20 meshes are crossed, according to volume mass than 5 times of amount (V/ are added
M) 30% ethyl alcohol refluxing extraction 3 times, extracts 1 hour every time, and filtration, filtrate merges, and ethyl alcohol is recovered under reduced pressure under the conditions of 60 DEG C,
Obtain medicinal extract；
(2) 5 times of amount (m/m) hot water are added in the medicinal extract for obtaining (1), is dispersed with stirring uniformly, places 18h；
(3) the medicinal extract liquid 4000rpm/min that (2) dispersion obtains is centrifuged 25min, discards supernatant liquid, must precipitates, 60 DEG C of items
It is dried in vacuo under part, crushes, obtain extract powder, it is spare；
(4) it pelletizes: the extract powder that (3) obtain being mixed with the maltodextrin of 1.5 times of mass ratioes, softwood processed, pelletized, done
It is dry, whole grain, obtain total particle to get.
Embodiment 5
E Seye 600g, sea-buckthorn 400g
(1) dry E Seye and sea-buckthorn medicinal material are taken, is crushed, 20 meshes are crossed, according to volume mass than 7 times of amount (V/ are added
M) 40% ethyl alcohol refluxing extraction 2 times, extracts 2.5 hours every time, and filtration, filtrate merges, and second is recovered under reduced pressure under the conditions of 70 DEG C
Alcohol obtains medicinal extract；
(2) 7 times of amount (m/m) hot water are added in the medicinal extract for obtaining (1), is dispersed with stirring uniformly, places for 24 hours；
(3) the medicinal extract liquid 5000rpm/min that (2) dispersion obtains is centrifuged 30min, discards supernatant liquid, must precipitates, 55 DEG C of items
It is dried in vacuo under part, crushes, obtain extract powder, it is spare；
(4) it pelletizes: the extract powder that (3) obtain being mixed with the maltodextrin of 2.5 times of mass ratioes, softwood processed, pelletized, done
It is dry, whole grain, obtain total particle to get.
Embodiment 6
E Seye 750g, sea-buckthorn 250g
(1) dry E Seye and sea-buckthorn medicinal material are taken, is crushed, 20 meshes are crossed, according to volume mass than 9 times of amount (V/ are added
M) 80% ethyl alcohol refluxing extraction 3 times, extracts 1.5 hours every time, and filtration, filtrate merges, and second is recovered under reduced pressure under the conditions of 60 DEG C
Alcohol obtains medicinal extract；
(2) 3 times of amount (m/m) hot water are added in the medicinal extract for obtaining (1), is dispersed with stirring uniformly, places 20h；
(3) the medicinal extract liquid 3500rpm/min that (2) dispersion obtains is centrifuged 25min, discards supernatant liquid, must precipitates, 65 DEG C of items
It is dried in vacuo under part, crushes, obtain extract powder, it is spare；
(4) it pelletizes: the extract powder that (3) obtain being mixed with the maltodextrin of 3 times of mass ratioes, softwood processed, pelletized, it is dry,
Whole grain, obtain total particle to get.
Embodiment 7
Influence of 2 product of embodiment to hyperglycemia high blood lipid model rat
1 experimental material
Streptozotocin (Sigma company), serum superoxide dismutases (SOD) kit, malonaldehyde (MDA) reagent
Box, (GSH-Px) kit, total cholesterol (TC) kit, triglycerides (TG) kit, low-density lipoprotein (LDL) reagent
Box, high-density lipoprotein (HDL) kit (Bioengineering Research Institute is built up in Nanjing), (Shandong pharmacy has metformin hydrochloride tablet
Limit company, lot number: 20160329).
2 experimental methods
2.1 Animal Models and grouping administration
Male SD rat 80, after 160~180g of weight, adaptable fed 5d, 10 are only used as normal group, with common base
Plinth forage feed, remaining 70 be only given high glucose and high fat feed (normal diet 60%, sucrose 20%, lard 10%, yolk powder 8%,
Cholesterol 1.5%, sodium taurocholate 0.5%) it feeds.After 4 weeks, after display increases, chain is injected intraperitoneally in rating model rat fat index
Urea helps rhzomorph (STZ) 35mg/kg, and (fasting 12h, streptozotocin are current with the preparation of pH4.4 citrate buffer solution before rat is injected
Now match), blood glucose is surveyed in blood sampling after 72h, and fasting blood sugar >=11.1mmol/L is modeling success rat.By 50 of screening qualification
Rat is randomly divided into 5 groups: model group, positive controls (metformin hydrochloride tablet, 25mg/kg/d), 2 product group of embodiment (are pressed
According to extract conversion crude drug amount administration, 100mg crude drug/kg/d), E Seye group (100mg crude drug/kg/d), sea-buckthorn group
(100mg crude drug/kg/d), while blank group is set up, blank group and model group give isometric physiological saline, successive administration 8
Measure index of correlation in week.
The measurement of 2.2 rat body weights
Respectively at administration the 2nd week, the 4th week, the 6th week, the 8th week measurement each group rat body weight.
The measurement of 2.3 rat fasting blood-glucoses
After administration the 2nd week, the 4th week, the 6th week, the 8th week Rat Fast can't help water, rat fasting blood-glucose is measured.
The measurement of 2.4 Oral Administration in Rats sugar dosis toleratas
When being administered 8 weeks, Rat Fast can't help water 12h, 30min after Yu Ci gastric infusion, and tail vein blood is surveyed on an empty stomach
Blood glucose value.The stomach-filling glucose 2.5g/kg after 30min surveys its sugar tolerance, i.e., 30 after stomach-filling, 60,120min take blood to survey blood glucose
Value.
2.6 serum superoxide dismutases (SOD), malonaldehyde (MDA), catalase (CAT), total cholesterol (TC),
Triglycerides (TG), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C) measurement
After 8th week last gastric infusion, each group Rat Fast 12h puts to death rat, centrifuging and taking blood after abdominal aortic blood
Clearly, the indexs such as SOD, MDA, CAT, TC, TG, LDL-C, HDL-C are measured.
2.7 statistical method
Test data is for statistical analysis using SPSS19.0 statistical software, statistic means standard deviationTable
Show, comparison among groups one-way analysis of variance
3 experimental results
Influence of 3.1 products of the embodiment of the present invention to hyperglycemia hyperlipemia rat weight
Influence of 1 product of the embodiment of the present invention of table to hyperglycemia hyperlipemia rat weight
Note: compared with model group,*P < 0.05,**P<0.01。
As seen from the results in Table 1, after rat modeling, except for the normal group, the appearance activity of remaining each group is reduced, food ration, drink
The phenomenon that water and urine volume increase, weight loss.After giving embodiment product, becoming for sustainable growth is still presented in each group rat body weight
Gesture, compared with model group, presentation significant difference (P < 0.01).Product of the embodiment of the present invention is individually answered with E Seye, sea-buckthorn
With comparing, the increase of rat model weight is obviously higher than the latter two.
Influence of 3.2 products of the embodiment of the present invention to hyperglycemia hyperlipemia rat fasting blood-glucose
Influence of 2 product of the embodiment of the present invention of table to hyperglycemia hyperlipemia rat fasting blood-glucose
Note: compared with model group,*P < 0.05,**P<0.01。
Before rat model administration, the equal conspicuousness of fasting blood glucose level rises.Stomach-filling embodiment product 2 weeks, 4 weeks, 6 weeks and 8
Zhou Hou, rat blood sugar significantly reduce, and compared with model group, have significant difference (P < 0.05 or 0.01), and the present invention is implemented
The blood sugar decreasing effect of example product is significantly better than exclusive use E Seye and sea-buckthorn, the chemiluminescence of the two are obvious.
Influence of 3.3 products of the embodiment of the present invention to hyperglycemia hyperlipemia rat oral glucose dosis tolerata
Influence of 3 product of the embodiment of the present invention of table to hyperglycemia hyperlipemia rat oral glucose dosis tolerata
Note: compared with model group,*P < 0.05,**P<0.01。
For table 3 the results show that when 0min, model group blood glucose is significantly higher than other each groups (P < 0.01).Gavage glucose solution
After 30min, 60min, 120min, each group blood glucose level has rising, and the blood glucose level at each group each time point is substantially less than mould
Type group (P < 0.05 or 0.01).Result also illustrates in table, and E Seye and sea-buckthorn are used cooperatively by the present invention, sugar tolerance experiment effect
It is substantially better than the group that E Seye and sea-buckthorn is used alone.
3.4 products of the embodiment of the present invention to hyperglycemia hyperlipemia rat SOD in serum, MDA, GSH-Px, TC, TG, LDL-C,
The influence of HDL-C
Influence of 4 product of the embodiment of the present invention of table to hyperglycemia hyperlipemia rat SOD in serum, MDA, GSH-Px
Note: compared with model group,*P < 0.05,**P<0.01。
Influence of 5 product of the embodiment of the present invention of table to hyperglycemia hyperlipemia rat serum TC, TG, LDL-C, HDL-C
Note: compared with model group,*P < 0.05,**P<0.01。
Table 4 is the results show that high glucose and high fat rat model, and each administration group SOD in serum, CAT are horizontal significantly raised, and MDA water
Flat decline is obvious, compared with model group, there is extremely significant sex differernce (P < 0.01), has for high glucose and high fat rat model good
Antioxidation, moreover, the antioxidant effect of product of the embodiment of the present invention is better than E Seye group, sea-buckthorn group.Table 5 the results show that
After giving rat model respective sample 8 weeks, serum TC, TG, LDL-C level, which have, to be substantially reduced, on HDL-C level is then obvious
It rises, each group has extremely significant sex differernce (P < 0.01), wherein the significant effect of product of the embodiment of the present invention compared with model group
Better than E Seye and sea-buckthorn, have the effect of explicitly cooperateing with enhancing.
Functional food prepared by the present invention has good therapeutic effect for high glucose and high fat rat model.It can drop
The blood glucose level of low rat model restores the growth of weight, improves the Glucose Tolerance of rat model.For the anti-of rat model
Oxidation index, product of the present invention can be improved SOD in serum, CAT level, reduce MDA level, enhance endogenous antioxidation system,
Mitigate response to oxidative stress, alleviates the development of hyperglycemia hyperlipidemia.Product of the present invention can also reduce the blood lipid level of rat model,
Serum TC, TG, LDL-C content are reduced, HDL-C content is improved, there is good effect for reducing blood fat to hyperglycemia high blood lipid model.
The present invention is preferred by many experiments, E Seye and sea-buckthorn is used cooperatively, hypoglycemic, effect for reducing blood fat is significantly better than list
E Seye, sea-buckthorn are solely used, the two has apparent chemiluminescence.
In summary experimental result is it is found that functional food of the invention can be used for height with hypoglycemic, effect for reducing blood fat
The prevention and treatment of blood glucose hyperlipidemia.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (4)
1. a kind of E Seye sea-buckthorn functional food, using E Seye, sea-buckthorn as primary raw material, each raw material containing by mass percentage
Amount are as follows: E Seye 20%~80%, sea-buckthorn 20%~80%.
2. a kind of E Seye sea-buckthorn functional food according to claim 1, it is preferable that the functional food is pressed by following
The raw material of mass percent meter is prepared: E Seye 40%~80%, sea-buckthorn 20%~60%.
3. the preparation method of E Seye sea-buckthorn functional food described in -2 any one according to claim 1, including following step
It is rapid:
(1) dry E Seye and sea-buckthorn medicinal material are taken, is crushed, 20 meshes are crossed, according to volume mass than 5-10 times of amount (V/m) is added
30%-90% ethyl alcohol, refluxing extraction 1-3 times are extracted 1-3 hours every time, and filtration, filtrate merges, and are depressurized under the conditions of 55-75 DEG C
Ethyl alcohol is recycled, medicinal extract is obtained；
(2) 3-8 times of amount (m/m) hot water is added in the medicinal extract for obtaining (1), is dispersed with stirring uniformly, places 12-24h；
(3) the medicinal extract liquid 3000-5000rpm/min that (2) dispersion obtains is centrifuged 10-30min, discards supernatant liquid, must precipitates,
It is dried in vacuo under the conditions of 50-70 DEG C, crushes, obtain extract powder, it is spare；
(4) it pelletizes: the extract powder that (3) obtain being mixed with the maltodextrin of 1-3 times of mass ratio, softwood processed, pelletized, it is dry, it is whole
Grain, obtain total particle to get.
4. the preparation method of E Seye sea-buckthorn functional food according to claim 3, the total particle is according to conventional system
Pulvis, jelly, biscuit, pressed candy is made in agent method.
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Cited By (1)
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|---|---|---|---|---|
| CN110368391A (en) * | 2019-06-21 | 2019-10-25 | 中国科学院西北高原生物研究所 | Triterpenoid is preparing the purposes in hypoglycemic Related product |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110368391A (en) * | 2019-06-21 | 2019-10-25 | 中国科学院西北高原生物研究所 | Triterpenoid is preparing the purposes in hypoglycemic Related product |
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