CN109663116A - A kind of Chinese medicine composition that treating nausea and vomiting caused by chemotherapy, free decoction granule and application - Google Patents
A kind of Chinese medicine composition that treating nausea and vomiting caused by chemotherapy, free decoction granule and application Download PDFInfo
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Abstract
A kind of Chinese medicine composition for treating nausea and vomiting caused by chemotherapy of the present invention, free decoction granule and application, belong to technical field of Chinese medicine.The Chinese medicine composition is made of following raw material medicaments: 6~15 parts of pinellia, 10~15 parts of rhizoma zingiberis, 6~15 parts of Huajuhong, 10~15 3~12 parts of part, meter swill Fructus Aurantii of PORIA ALBA, 10~15 parts of Pogostemon cablin, 2~4 parts of prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, 3~5 parts of stir-baked RADIX SCUTELLARIAE with yellow rice wine, 15~30 parts of reed root, 5~12 parts of caulis bambusae in taenian, 5~9 parts of perilla leaf, 9~15 parts of RADIX CODONOPSIS PILOSULAE from Shanxi of China and 2~6 parts of licorice.The free decoction granule is made of the single medicinal material granule of above-mentioned parts by weight.Chinese medicine composition, free decoction granule treat the application in nausea and vomiting drug caused by chemotherapy in preparation.The present invention have replenish qi to invigorate the spleen, harmonizing stomach and lowering adverse Qi, relieving distension and oppression；Immunity of organism is adjusted, tumour growth is inhibited；It is shared with chemotherapeutic and plays synergic sensitizion, alleviate symptoms of emesis；The advantages of adjusting alimentary canal function.
Description
Technical field
The invention belongs to technical field of Chinese medicine, and in particular to a kind of Chinese traditional medicine composition for treating nausea and vomiting caused by chemotherapy
Object, free decoction granule and application.
Background technique
In world wide, malignant tumour is to be only second to the cardiopathic second largest cause of death.Chemotherapy is treating malignant tumor
One of core mode, nausea and vomiting caused by chemotherapy (Chemotherapy-induced nausea and vomiting,
CINV) it is its common adverse reaction, seriously affects the life quality and wholistic therapy of patient.
CINV present Research:
1, classify: being divided into acute, retardance, expected property, burst and intractable 5 seed type.
1. acute nausea and vomiting: administration is typically occurred in several minutes to a few hours, and reaches peak within 5~6 hours upon administration,
But mostly alleviate in 24 hours.
2. delayed nausea and vomiting: mostly occur after chemotherapy 24 hours, be common in cis-platinum, carboplatin, cyclophosphamide and Ah
When mycin chemotherapy, it can last for days.
3. it is expected that property nausea and vomiting: after referring to that patient experienced uncontrollable CINV in a preceding chemotherapy, under
The nausea and vomiting that chemotherapy occurs before starting, are a kind of conditioned reflex, cause mainly due to psychic factor etc..
4. burst vomiting: refer to even if carried out prevention processing but still occur vomiting, and need carry out " rescue property control
It treats ".
5. intractable vomiting: refer in previous chemotherapy cycles and is failed using preventative and/or rescue property anti-emesis treatment, and
It is still vomitted in next chemotherapy cycles.
2, the emetic classification of anti-tumor drug: anti-tumor drug can be generally divided into height cause spit risk (HEC, such as it is suitable
Platinum, cyclophosphamide etc.), moderate cause spit risk (MEC, such as oxaliplatin, Irinotecan), low emetic risk (such as Ji Xita
Shore, Japanese yew class etc.) and 4 emetic risk class such as slight emetic risk, refer to if prevent processing incidence of vomiting
Respectively 90%, 30%~90%, 10%~30% and < of > 10%.
3, CINV incidence is high, it is big to influence: comprehensive literature report, CINV incidence are 70%~80%, wherein expected property
Nausea and vomiting account for 10%~44%.The vomiting of light moderate often results in that patient's mood is more irritated, and the vomiting of middle severe will affect disease
People's diet and nutrition, or even cause electrolyte disturbance, What is more is forced to interrupt chemotherapy, influence life in patients and
Wholistic therapy.
4, Western medicine is expensive, side effect is big: Western medicine such as 5-HT3Although receptor antagonist and nk 1 receptor antagonistic curative effect
The problems such as prominent, but there are expensive, side effect is big, adverse reaction at a specified future date is unclear.In addition, being applied to clinic at present
Although antiemetic kind is more, efficiently, the antiemetic of multiple target point it is less.
Chemotherapeutics is also normally organized carefully as a kind of toxicant in damage body while killing tumor cell
Born of the same parents, body tissue and organ are generated larger side effect, especially easily cause gastrointestinal function by different degrees of harm and influence
Disorder causes to seriously affect to patients ' life quality, reduces Compliance With Chemotherapy.Therefore, it is badly in need of a kind of drug to alleviate or treat
Nausea and vomiting caused by tumor chemotherapeutic drug will provide safeguard for going on smoothly for oncotherapy.
Summary of the invention
Nausea and vomiting caused by chemotherapy (CINV) belong to traditional Chinese medicine " vomiting " scope, belong to the imbalance of taste elevating function, gallbladder stomach not
And person.Symptoms include Nausea and vomiting, hiccup, chest distress and palpitation symptoms, agitation, defecate unfavorable (constipation or shapeless) at stomach duct and abdomen discomfort.Tongue fur is white
Or yellow greasy, wiry and rolling pulse or string are slow.
Vomiting, middle coke Qi dysfunction, gallbladder stomach disturbance in functioning of QI are its basic pathogenesis.Chemotherapeutics is a kind of medicine toxicity, is had
Energy and blood of human body is upset, the characteristics of viscera function operates normally is influenced；Chemotherapeutics impairing the spleen and stomach makes transporting and transforming function of the spleen and stomach dysfunction,
The turbid interior life of disturbance in ascending and descending, phlegm, stomach Qi rising then Nausea and vomiting, stomach Qi upward reversal move diaphragm then hiccup；Incoordination between the spleen and the stomach, courage multiplies it,
Gallbladder lose catharsis, production of phlegm due to stagnation of QI, phlegm it is turbid in disturb, upset the mind, it is seen that chest distress and palpitation symptoms, agitation；Gallbladder stomach discord, it is seen that stomach duct and abdomen is uncomfortable；
The impaired cause of spleen and stomach function is weakness of the spleen and the stomach, then sees and defecate unfavorable (constipation or shapeless), and wiry and rolling pulse or string are slow etc..
It is an object of the invention to the Chinese medicines and doctor trained in Western medicine symptom according to above-mentioned CINV, disclose a kind of Chinese medicine for treating CINV
Composition.
It is an object of the invention to disclose a kind of Chinese medicine composition for treating nausea and vomiting caused by chemotherapy.
Second object of the present invention is to disclose the application of above-mentioned Chinese medicine composition.
Third purpose of the present invention is to disclose a kind of free decoction granule for treating nausea and vomiting caused by chemotherapy.
4th purpose of the invention is to disclose the application of above-mentioned Chinese medicine single herbal concentrate-granule.
The purpose of the present invention is what is be achieved through the following technical solutions:
A kind of Chinese medicine composition for treating nausea and vomiting caused by chemotherapy, wherein the Chinese medicine composition is by following weight parts
Bulk pharmaceutical chemicals composition: 6~15 parts of pinellia, 10~15 parts of rhizoma zingiberis, 6~15 parts of Huajuhong, 10~15 part, meter swill trifoliate orange of PORIA ALBA
3~12 parts of shell, 10~15 parts of Pogostemon cablin, 2~4 parts of prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, 3~5 parts of stir-baked RADIX SCUTELLARIAE with yellow rice wine, 15~30 parts of reed root, 5~12 parts of caulis bambusae in taenian,
5~9 parts of perilla leaf, 9~15 parts of RADIX CODONOPSIS PILOSULAE from Shanxi of China and 2~6 parts of licorice.
Chinese medicine composition described in above-mentioned technical proposal, wherein the parts by weight of each bulk pharmaceutical chemicals are as follows: 15 parts of pinellia,
15 parts of rhizoma zingiberis, 15 parts of Huajuhong, 15 12 parts of part, meter swill Fructus Aurantii of PORIA ALBA, 15 parts of Pogostemon cablin, 4 parts of prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, 5 parts of stir-baked RADIX SCUTELLARIAE with yellow rice wine,
30 parts of reed root, 12 parts of caulis bambusae in taenian, 9 parts of perilla leaf, 15 parts of RADIX CODONOPSIS PILOSULAE from Shanxi of China and 6 parts of licorice.
Chinese medicine composition described in above-mentioned technical proposal treats the application in nausea and vomiting drug caused by chemotherapy in preparation.
A kind of free decoction granule for treating nausea and vomiting caused by chemotherapy, wherein the free decoction granule is under
State the single medicinal material granule composition of parts by weight: 6~15 parts of pinellia, 10~15 parts of rhizoma zingiberis, 6~15 parts of Huajuhong, white
10~15 3~12 parts of part, meter swill Fructus Aurantii of Poria cocos, 10~15 parts of Pogostemon cablin, 2~4 parts of prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, 3~5 parts of stir-baked RADIX SCUTELLARIAE with yellow rice wine, reed root 15
~30 parts, 5~12 parts of caulis bambusae in taenian, 5~9 parts of perilla leaf, 9~15 parts of RADIX CODONOPSIS PILOSULAE from Shanxi of China and 2~6 parts of licorice.
Free decoction granule described in above-mentioned technical proposal, which is characterized in that each single medicinal material granule
Parts by weight are as follows: 15 parts of pinellia, 15 parts of rhizoma zingiberis, 15 parts of Huajuhong, 15 12 parts of part, meter swill Fructus Aurantii of PORIA ALBA, 15 parts of Pogostemon cablin,
4 parts of prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, 5 parts of stir-baked RADIX SCUTELLARIAE with yellow rice wine, 30 parts of reed root, 12 parts of caulis bambusae in taenian, 9 parts of perilla leaf, 15 parts of RADIX CODONOPSIS PILOSULAE from Shanxi of China and 6 parts of licorice.
Free decoction granule described in above-mentioned technical proposal treats answering in nausea and vomiting drug caused by chemotherapy in preparation
With.
The present invention is CINV basic pathogenesis for " middle coke Qi dysfunction, gallbladder stomach disturbance in functioning of QI ", using " regulating functional activities of qi, rush
It is vaporized " treatment method, Chinese traditional treatment mechanism of the invention is as follows:
Selecting pinellia, rhizoma zingiberis is monarch drug in a prescription, and the tuber of pinellia is pungent, warm, toxic, eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, ginger system
Its toxicity can be restricted；Rhizoma zingiberis is pungent, hot, warming spleen and stomach for dispelling cold, recover Yang and smooth venation, warming lung and resolving fluid, can in the scattered lung of temperature cold-evil and sharp lung qi it
Respectful drop, makes logical adjust of water channel and phlegm retention can be changed, and can the turbid and exhausted the source of producing phlegm of warm taste clearing damp；Two medicines are monarch drug in a prescription, drug combination altogether
The dissipation role of strongly fragrant wet turbid and its formation phlegm wet is in enhancing with ventilator；
Ministerial drug is with Huajuhong acrid, bitter, warm, cold dispelling, eliminating dampness, sharp gas, dissolving phlegm；Fructus Aurantii is bitter, pungent, sour, slightly cold, and qi-regulating is wide
In, the stagnant dissipate-swelling of row, the inverse of gallbladder stomach can be dropped, its pungent dry and laxation can be weakened with water in which rice has been washed immersion and acted on, and can enhance tonifying spleen and in
Effect；Exocarpium Citri Rubrum is harmonious with Fructus Aurantii, and a temperature one is cool, increases the power of regulating qi-flowing for eliminating phlegm.PORIA ALBA is sweet, light, flat, inducing diuresis for removing edema, excreting dampness,
Invigorating the spleen, calming heart, with the source of producing phlegm of shutting out.Pogostemon cablin gas fragrance, pungent, tepor, dampness elimination, preventing or arresting vomiting, relieving summer-heat are shared with the tuber of pinellia, and one with virtue
Sweetening treatment is wet, and one with pungent-warm eliminating dampness, has the function for adjusting taste, and enhance the power of preventing or arresting vomiting；
Adjutant radix scutellariae, coptis hardship, cold, heat-clearing and damp-drying drug, purging fire for removing toxin let out coke mechanism of qi in middle burnt hot, adjusting strongly fragrant long, radix scutellariae
Wine system can mitigate the property of its bitter cold, and coptis ginger system is longer than clearing heat to ease the stomach preventing or arresting vomiting；Radix scutellariae, coptis hardship drop, rhizoma zingiberis is pungent to open, drug combination
The pungent function for opening bitter drop to be played altogether, and spleen is enable to rise clearly, turbid, QI movement being in harmonious way and the generation for reducing Nausea and vomiting can drop in stomach, and just so-called " one
A drop is risen, mechanism of qi reconciles；One Wen Yihan, yin-yang are coordinated ".Reed root is sweet, cold, and clearing heat-fire promotes the production of body fluid to quench thirst, relieving restlessness, preventing or arresting vomiting, benefit
Urine is rushed down clearly, preventing or arresting vomiting effect with increase.Caulis bambusae in taenian is sweet, slightly cold, and clearing heat and eliminating phlegm relieves restlessness and prevents vomiting；Caulis bambusae in taenian and tuber of pinellia phase 5, a temperature one is cool,
Enhance the function of resolving sputum stomach function regulating, preventing or arresting vomiting relieving restlessness.Perilla leaf is pungent, warm, expelling cold and relieving exterior syndrome, regulating the flow of QI to ease the stomach, and the wide chest benefit diaphragm of energy, lifting mechanism of qi make
Phlegm has source, and enhancing promotees mechanism of qi effect；
Make medicine ginseng, Radix Glycyrrhizae, first is that the gas to strengthen the spleen and stomach, gas is conducive to the dissipation of moisture enough；Second is that being conducive in clean air
It rises, clean air, which rises, is then conducive to foul smell decline, plays strengthening the spleen and replenishing qi, promotes gasification, and Radix Glycyrrhizae can coordinating the drug actions of a prescription；
Formula cautiously grasping pathogenesis in the present invention, compatibility is precise and appropriate, and the efficacy of a drug is concentrated, and above all medicine phases 5 can make the healthy tendency of virtual loss
It is helped, the turbid heresy of phlegm is able to removing summer-heat dissipation, and the function of taste gallbladder is able to adjust smooth, plays righting altogether and disappears the inverse function of ruffian drop.
Single medicinal material granule used in free decoction granule is with the tradition for meeting concocted specification in the present invention
The prepared slices of Chinese crude drugs extract through modern pharmaceutical technology, are concentrated, separate, dry, pelletize, pack refined pure Chinese medicine as raw material
Product line.The purpose for releasing the product is intended as the substitute of traditional Chinese medicine medicine materical crude slice for clinical formulation use.The product
Effective ingredient, nature and flavor, channel tropism, cure mainly, effect and traditional Chinese medicine medicine materical crude slice it is completely the same.Therefore, it had both maintained the former prepared slices of Chinese crude drugs
Whole features --- can satisfy doctor carry out diagnosis and treatment, with card plus-minus, pharmacological property is strong, drug effect is high, while again have be not required to
It decocts, directly take after mixing it with water, dose is few, effect is rapid, composition is complete, curative for effect, safety and sanitation, carries preservation conveniently, easily
In adjusting and many advantages, such as suitable industrialized production.Single medicinal material granule is derived from traditional Chinese medicine medicine materical crude slice, and compares tradition
Medicine materical crude slice has bigger superiority.
Chemical composition of Chinese materia medica is the material base of herbal pharmacology effect.The free decoction for the treatment of CINV of the present invention
The primary efficacy of granula (hereinafter referred to as: half particle of reed grass temperature) is to replenish qi to invigorate the spleen, harmonizing stomach and lowering adverse Qi, relieving distension and oppression, for CINV
The basic pathogenesis of " middle coke Qi dysfunction, gallbladder stomach disturbance in functioning of QI " is treated.Modern pharmacological research proves, drug composition it is each at
Dividing has certain adjusting immunity of organism, inhibits tumour growth effect；It is shared with chemotherapeutic and plays synergic sensitizion, alleviate vomiting disease
Shape and have adjust the effect of alimentary canal function.Modern pharmacological research data is shown:
(1), the effect of replenishing qi to invigorate the spleen of Chinese medicine focuses primarily upon the adjusting immunity of organism of its effective component, inhibits tumour raw
Long effect；
(2), harmonizing stomach and lowering adverse Qi effect, which is to share with chemotherapeutic, plays synergic sensitizion, alleviates symptoms of emesis；
(3), relieving distension and oppression effect is related with alimentary canal function is adjusted.
The traditional chinese medicine composition of the invention, free decoction granule are respectively provided with following effects for above-mentioned 3 points:
(1), the effect of replenishing qi to invigorate the spleen of Chinese medicine, which focuses primarily upon its effective component, has adjusting immunity of organism, inhibits tumour
Growth:
Chemotherapeutics can damage human righteousness, cause is weakness of the spleen and the stomach, healthy energy is insufficient, therefore while killing tumour cell
The class that replenishes qi to invigorate the spleen Chinese medicine can building up healthful vital energy, adjust immunity of organism, invigorating the spleen with exhausted the source of producing phlegm, inhibit tumour growth.
(1) pinellia tuber extract inhibits tumour to increase reproduction by enhancing reticuloendothelial system phagocytic function and secretion,
Inducing apoptosis of tumour cell plays antitumaous effect.Pinellia tuber extract is to S180、H22, EAC have inhibiting effect, can induce SH-SY5Y,
PCI2Apoptosis, to PCI2There are inhibition growth and proliferation function.The Method of Polysaccharide in Radix Pinellia component that methanol extracts has polymorphonuclear leukocyte
Inducibility, thus it is speculated that it leads to the cell effect of tumor destruction by activation polymorphonuclear leukocyte.
(2) Rhizoma Zingiberis extract has Biphasic Regulation to body's immunity, has to the humidification of cell factor
Time dependent, interleukin (IL)-l of cell monolayer, IL-3, IL-6 and granulocyte-macrophage colony-stimulating factor (GM-CSF)
It is dramatically increased in the presence of low concentration dry ginger extract, and higher concentration is without this humidification.Rhizoma Zingiberis extract passes through
Promote Apoptosis to play cytotoxicity and inhibits tumor proliferation.
(3) flavones active component naringenin, apiolin, Rhoifolin etc. have inhibition tumour cell raw in Huajuhong
Long effect.Naringenin can reduce lung neoplasm size, slow down tumor growth rate, inhibit tumor of breast transfer；Dish element can lead to
Spending the change cell cycle induces cell apoptosis, and can press down the growth of Multidrug Resistance of Gastric Cancer cell, can increase with concentration and the time extends
Increase the apoptosis rate of cell.
(4) pachymaran can be such that the content of immune factor IL-2 and TNF-α in mice serum obviously increases, moreover it is possible to increase
IL-2, TNF-α, IL-6, IFN-γ potency, the function of improving lymphocyte and macrophage, cause anti-Patrick's knot, mesenterium leaching
CD3 in fawning on+、CD19+The variation of cell proportion and the biosynthesis for promoting IgA, IgG and IgM in mice serum.Poria cocos is more
Sugar can enhance Tumor Necrosis factor activity and natural killer cell activity, and tumor necrosis factor is that one kind of macrophages secrete is more
Sugar, it can directly participate in killing of the monocyte to tumour cell, and by suppressor transcriptional activity, specifically reduce mcy
The expression of gene mRNA increases the mRNA expression of HLA, enhancing cell immune system especially CTL activity, indirectly
Play the role of killing tumor cell.
(5) Patchoulicalcohol is by activated mononuclear phagocytosis system, and enhancing humoral immune response plays immunoregulation effect, in body
External enwergy inhibits colon cancer cell HCT116 and SW480, and expression and the histone deacetylase of energy inhibition of histone deacetylase 2
Change the activity of enzyme, lower proto-oncogene (cmyc) and activating transcription factor NF-B access, and then inhibits cell differentiation and promote thin
Born of the same parents' apoptosis plays antitumor action.
(6) berberine passes through killing tumor cell, inhibits tumor cell proliferation, induces cell apoptosis and inhibit cell invasion
Antitumor action is played with transfer.Berberine can inhibit the degradation of the inhibition albumen of nuclear factor К B in lung carcinoma cell, lead to IL-1
β and TNF-α, which generate, increases and then promotes Increase Apoptosis of Lung Cancer Cells, plays therapeutic effect to lung cancer；Berberine is also through downward matrix
Metalloproteinases and plasma urokinase-type plasminogen activator and play reduce lung carcinoma cell invasive ability effect.
(7) radix scutellariae can increase body's immunity, resistivity of the enhancing body to virus；Baical skullcap root flavonoids fractions can be with
It adjusts amino acid metabolism by influencing Cycloxygenase (COX) and lipoxidase (LOX) approach and plays antitumor action.
(8) purple perilla has humidification to immune function of mice, can stimulate the generation and release of IL-2 and IgM, purple perilla mentions
It takes object to have and inhibits cancer cell multiplication, the effect of cancer cell specific induction of apoptosis.
(9) Codonopsis pilosula polysaccharide can enhance reticuloendothelial system phagocytic function, increases spleen index and promote the generation of hemolysin,
Adjust body's immunity.Codonopsis pilosula polysaccharide can be such that karyopyknosis, apoptotic body occurs, to Hepatocellular carcinoma cell line cell
Play inhibiting effect.
(10) licorice polysaccharide can effective stimulus T lymphocyte proliferation with activity, achieve the effect that resistance building, also have
Have and immunoglobulin is promoted to generate, inhibits the effectiveness of complement activity；Enoxolone can be swollen by inducing apoptosis of tumour cell, inhibition
Oncocyte invasion, inhibit the approach such as tumor multi-medicine drug-resistant to play antitumaous effect at induction tumor cell differentiation.
(12) body's immunity is adjusted in exquisite polysaccharide in Fructus Aurantii.Nobiletin has good antitumous effect.Reed
Root polysaccharide has the function of anti peroxidation of lipid, extracorporeal anti-tumor and improves disorders of lipid metabolism.Caulis bambusae in taenian polysaccharide has exempts from vitro
Epidemic disease adjusts activity, enhances body's immunity.
(2), harmonizing stomach and lowering adverse Qi effect, which is to share with chemotherapeutic, plays synergic sensitizion, alleviates symptoms of emesis:
Harmonizing stomach and lowering adverse Qi class Chinese medicine can make middle burnt QI movement being in harmonious way, and transporting and transforming function of the spleen and stomach function normally then vomits alleviation；Taste mechanism of qi
Tune is smooth, gallbladder stomach Qiization is normal, shares synergic sensitizion with chemotherapeutic, improves curative effect.
(1) tuber of pinellia alcohol extract can inhibit cancer cell that will pump out carefully by the expression of downward cell membrane pump-glycoprotein p170
It is extracellular, it can partially reverse multiple medicine-resistant cell line K562/A02 cell to the drug resistance of anticarcinogen, improve curative effect；And it can be effectively relieved
The diseases such as Nausea and vomiting caused by chemotherapeutics, food-intake decline.The tuber of pinellia is by inhibiting vomiting centre, activation vagus nerve to pass
Activity plays anti-vomiting effect out, and anti-vomiting effect ingredient and methionine, glycine, alkaloid, glucuronic acid glycoside etc. are related.
(2) rhizoma zingiberis chemical component 6-gingerol is reduced Survivin albumen and is inhibited by the expression of downward birc-5mRNA
The apoptosis of tumour cell generates killing and Chemosensitizing effect to human hepatoma cell strain HepG-2 cell, in Hypoxia-hypoglycemia environment
In it is this effect performance become apparent.
(3) berberine can induce SKOV3 Apoptosis, lowers Bcl-2, Survivin gene and raises the table of Bax gene
It reaches, moreover it is possible to restore the methylation state of hMLH1 promoter and enhance the expression of hMLH1mRNA, collaboration enhancing anticancer drug resists
Function of tumor.
(4) Shenqi extraction inhibits the generation of lung cancer tumor capilary to taxol and metastases is inhibited to have certain increasing
Use is pretended, also can reduce chemotherapy toxic side effect, and the ginseng and astragalus injection liquid of high dose can inhibit lung carcinoma cell thin to blood vessel endothelium
The chemotaxis of born of the same parents.
(5) complex polysaccharide of pachymaran, wogonin and chemotherapeutics, which share, can improve curative effect, moreover it is possible to mitigate chemotherapy
The side effects such as drug Nausea and vomiting.The different ketone of purple perilla (IK) has significant synergic sensitizion effect to the radiotherapy of liver cancer cells.Pogostemon cablin
Normal hexane extract has certain antagonism to vomiting.
(3), relieving distension and oppression effect is related with alimentary canal function is adjusted:
Chemotherapeutics impairing the spleen and stomach, leads to spleen deficiency, and feeling of fullness is to lead to the most common complication of patient's spleen deficiency after chemotherapy.Patient
Often there is loss of appetite, gastral cavilty turgor etc. " feeling of fullness disease " performance, traditional Chinese medicine has unique curative effect in terms of adjusting alimentary canal function.
(1) pinellia tuber extract can be by reducing gastric secretion, reducing gastric juice free acidity and total acidity, inhibition stomach cardia
Antiulcer is played the role of in enzymatic activity, promotion stomach lining reparation etc.；It has dual regulation to intestine in vitro, may act on second
Acetylcholine receptor and generate contraction, may also suppress acetylcholine, histamine, intestinal contraction caused by barium chloride.
(2) rhizoma zingiberis has slight stimulation effect to alimentary canal, can make intestines tension, the rhythm and pace of moving things and enhancing of wriggling, promote disappearing for stomach and intestine
Change function.
(3) Fructus Aurantii has dual regulation to gastrointestinal smooth muscle, both can excited gastrointestinal smooth muscle, reinforce gastrointestinal peristalsis,
The tension and spasmolysis of gastrointestinal smooth muscle can be reduced again；Fructus Aurantii is mediated and by cholinergic recepter, serotonin to smooth
The directly effect of flesh plays depression effect.
(4) Pogostemon cablin water extract and the water extract that deoils can inhibit intestines caused by the normal Intestinal pushing and neostigmine of mouse
It promotes, increases gastric acid secretion, enhance the vigor of pepsin serum amylase and the function of pancreatic secretion enzyme, and Pogostemon cablin volatilizees
Oil without influence, and reduces gastric acid secretion Intestinal pushing, has improvement result to digestive function.
(5) Total base coptis can reduce interior free yl, mitigate lipid peroxidation, check iNOS overexpression, maintain stomach glutinous
The NO content of film plays the protective effects on gastric mucosa in normal level.
(6) radix scutellariae decoction has inhibiting effect to the movement of small intestine, can be relieved intestinal smooth muscle spasm.Codonopsis pilosula polysaccharide is by having
Effect slows down inflammatory reaction, reaches protection enteron aisle villus, crypts effect, can improve caused by chemotherapeutic medicines intestinal mucosa symptom.Liquiritin
Have the function of antiulcer activity, adjusts gastrointestinal function, improves body function.
The invention has the following advantages:
1, replenish qi to invigorate the spleen, harmonizing stomach and lowering adverse Qi, relieving distension and oppression the effect of.
2, have and adjust immunity of organism, inhibit tumour growth effect.
3, have to share with chemotherapeutic and play the role of synergic sensitizion, alleviate symptoms of emesis.
4, have and adjust the effect of alimentary canal function.
Specific embodiment:
In order to make the technical solution of the present invention easy to understand, chemotherapy institute is treated below in conjunction with specific test example is a kind of to the present invention
The Chinese medicine composition, free decoction granule and application of nausea and vomiting is caused to be further described.
Embodiment 1: the preparation of Chinese medicine composition:
Weigh pinellia 6g, rhizoma zingiberis 10g, Huajuhong 6g, PORIA ALBA 10g, rice swill Fructus Aurantii 3g, Pogostemon cablin 10g, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice
2g, stir-baked RADIX SCUTELLARIAE with yellow rice wine 3g, reed root 15g, caulis bambusae in taenian 5g, perilla leaf 5g, RADIX CODONOPSIS PILOSULAE from Shanxi of China 15g and licorice 2g.
Embodiment 2: the preparation of Chinese medicine composition:
Weigh pinellia 10g, rhizoma zingiberis 12g, Huajuhong 10g, PORIA ALBA 12g, rice swill Fructus Aurantii 7g, Pogostemon cablin 12g, turmeric
Even 3g, stir-baked RADIX SCUTELLARIAE with yellow rice wine 4g, reed root 20g, caulis bambusae in taenian 8g, perilla leaf 7g, RADIX CODONOPSIS PILOSULAE from Shanxi of China 12g and licorice 4g.
Embodiment 3: the preparation of Chinese medicine composition:
Weigh pinellia 15g, rhizoma zingiberis 15g, Huajuhong 15g, PORIA ALBA 15g, rice swill Fructus Aurantii 12g, Pogostemon cablin 15g, ginger
Coptis 4g, stir-baked RADIX SCUTELLARIAE with yellow rice wine 5g, reed root 30g, caulis bambusae in taenian 12g, perilla leaf 9g, RADIX CODONOPSIS PILOSULAE from Shanxi of China 15g and licorice 6g.
Embodiment 4: the preparation of free decoction granule:
Weigh the single medicinal material granule of following weight: pinellia 6g, rhizoma zingiberis 10g, Huajuhong 6g, PORIA ALBA 10g,
Rice swill Fructus Aurantii 3g, Pogostemon cablin 10g, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice 2g, stir-baked RADIX SCUTELLARIAE with yellow rice wine 3g, reed root 15g, caulis bambusae in taenian 5g, perilla leaf 5g, RADIX CODONOPSIS PILOSULAE from Shanxi of China 15g and Sheng Gan
Careless 2g.
Single medicinal material granule in the present embodiment is purchased from Tianjiang Pharmaceutical Industry Co., Ltd., Jiangyin.
Embodiment 5: the preparation of free decoction granule:
Weigh the single medicinal material granule of following weight: pinellia 10g, rhizoma zingiberis 12g, Huajuhong 10g, PORIA ALBA
12g, rice swill Fructus Aurantii 7g, Pogostemon cablin 12g, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice 3g, stir-baked RADIX SCUTELLARIAE with yellow rice wine 4g, reed root 20g, caulis bambusae in taenian 8g, perilla leaf 7g, RADIX CODONOPSIS PILOSULAE from Shanxi of China 12g and
Licorice 4g.
Single medicinal material granule in the present embodiment is purchased from Tianjiang Pharmaceutical Industry Co., Ltd., Jiangyin.
Embodiment 6: the preparation of free decoction granule
Weigh the single medicinal material granule of following weight: pinellia 15g, rhizoma zingiberis 15g, Huajuhong 15g, PORIA ALBA
15g, rice swill Fructus Aurantii 12g, Pogostemon cablin 15g, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice 4g, stir-baked RADIX SCUTELLARIAE with yellow rice wine 5g, reed root 30g, caulis bambusae in taenian 12g, perilla leaf 9g, RADIX CODONOPSIS PILOSULAE from Shanxi of China 15g
With licorice 6g.
Single medicinal material granule in the present embodiment is purchased from Tianjiang Pharmaceutical Industry Co., Ltd., Jiangyin.
Illustrate a kind of free decoction particle for treating nausea and vomiting caused by chemotherapy of the present invention below by way of specific test example
Possessed by agent (hereinafter referred to as: half particle of reed grass temperature) the utility model has the advantages that
Test example 1: the half granule clinical application of reed grass temperature:
(1), nausea and vomiting caused by chemotherapy (CINV) use the diagnostic criteria of the drug therapy:
Western medicine diagnostic criteria: " oncotherapy related vomiting guideline of prevention and treatment (2014 editions) " issue referring to CRPC and ASMC is marked
Quasi- and progress.
Definition: with the nausea and vomiting occurred during chemotherapy of tumors.
The type of CINV: acute, retardance, expected property, burst and intractable 5 seed type.
Tcm diagnosis standard: referring to bureau of drug administration, Ministry of Health of the People's Republic of China about " new Chinese medicine clinical research guidance
Principle " (version in 2002) " new Chinese medicine is attenuated to chemicotherapy and/or synergistic effect " Some principles, People's Republic of China's Chinese medicine
Medicine professional standard " tcm internal medicine disease Standardization of diagnosis and curative effect " (ZY/T001.1-94), national higher institutions of Chinese medicine programming textbook
Chinese Internal Medicine (the 9th edition) " vomiting ", " tcm clinical practice diagnosis and treatment term syndrome part " (National Standard of the People's Republic of China),
It is formulated on the basis of distinguished veteran doctors of TCM Liu Huawei's clinical experience and questionnaire survey.
The core interpretation of the cause, onset and process of an illness: middle coke qi-movement disturbance, gallbladder stomach disturbance in functioning of QI.
Primary symptom: Nausea and vomiting；
Minor symptom: hiccup, stomach duct and abdomen is uncomfortable, chest distress and palpitation symptoms, irritated, defecates unfavorable (constipation or shapeless)；
Tongue vein: tongue fur is white or yellow greasy, wiry and rolling pulse or string are slow.
Primary symptom is indispensable, and 1 combination tongue vein of minor symptom, that is, diagnosable.
(2), CINV curative effect judging standard:
Nausea and vomiting is divided into acute stage and period of delay, and acute stage is defined as in 24 hours that chemotherapy starts, period of delay regulation
24 hours to 120 hours started for chemotherapy.Vomiting complete incidence graph (CR) is defined as without vomiting and rescue drug is not used；Nausea
Complete incidence graph (CR) is defined as nausea scoring (visual analogue scales) VAS≤5mm.
(3), the half effective case of granule therapy CINV of reed grass temperature:
Case one: Ma, male, 60 years old, Xianyang, Shanxi province city Jingyang County credit Lian She Families Home, admission number 241305
The first visit time: on June 30th, 2017.
Main suit: lung cancer is made a definite diagnosis 1 week.
Present illness history: patient coughed before 1 week without obvious inducement, and with shortness of breath, it is pernicious to be diagnosed as lung in conjunction with coherence check
Tumour (gland cancer), carry out 1 period chemotherapeutic drug therapy, and chemotherapeutics is the specific scheme is that docetaxel (d1-d3), cis-platinum (d1-
D3), it is uncomfortable to occur Nausea and vomiting, stomach duct and abdomen after chemotherapy, after taking orally (specifically unknown) treatment of correlation antiemetic, symptom is not alleviated,
It is now that traditional Chinese medicine treatment is asked to go to a doctor then.Symptoms include: Nausea and vomiting, hiccup, stomach duct and abdomen are uncomfortable, cough, cough up a small amount of white viscous phlegm, cough up phlegm
Unfavorable, blood-stained sputum silk, uncomfortable in chest, shortness of breath is out of strength, receives difference, and night is not poor, urine tune, and stool is dry.Tongue nature is light red, and tongue fur is white, veins string
It is sliding.
Past medical history: previously having " diabetes B " medical history 5 years, now takes orally " diformin tablet, glipizide tablet ", blood glucose control
System is fine；" lacunar infarction " 2 months.
Tcm diagnosis: internal medicine carninomatosis, card belong to asthenia of pulmonosplenic qi, gallbladder stomach discord card.
Doctor trained in Western medicine diagnosis: 1, malignant tumor of lung (gland cancer)；2, patients with type Ⅰ DM；3, lacunar infarction.
Therapy: help lung spleen, stomach function regulating cholagogue.
Chinese medicine: half particle of reed grass temperature, specific medication are as follows: pinellia 15g, rhizoma zingiberis 15g, Exocarpium Citri Rubrum 15g, Poria cocos 15g, Fructus Aurantii
12g, wrinkled giant hyssop 15g, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice 4g, stir-baked RADIX SCUTELLARIAE with yellow rice wine 5g, reed root 30g, caulis bambusae in taenian 12g, perilla leaf 9g, Radix Codonopsis 15g, licorice 6g.6 doses, water
It takes after mixing it with water, day is one, takes in two times.
Reexamination time: on July 6th, 2018
Patient tells Nausea and vomiting, hiccup, the alleviation of stomach duct and abdomen malaise symptoms after 6 doses of medication, and cough, shortness of breath mitigate, out of strength slow
It solves, without the trace of blood in phlegm, food of receiving is general, and night is not general, and two just adjust, and tongue nature is light red, and tongue fur is white, wiry and rolling pulse.
Chinese medicine: half particle of reed grass temperature, specific medication are as follows: pinellia 15g, rhizoma zingiberis 15g, Exocarpium Citri Rubrum 15g, Poria cocos 15g, Fructus Aurantii
12g, wrinkled giant hyssop 15g, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice 4g, stir-baked RADIX SCUTELLARIAE with yellow rice wine 5g, reed root 30g, caulis bambusae in taenian 12g, perilla leaf 9g, Radix Codonopsis 15g, licorice 6g.7 doses, water
It takes after mixing it with water, day is one, takes in two times.
Pay a return visit: patient tells that alimentary canals, the respiratory tract malaise symptoms such as Nausea and vomiting, cough, shortness of breath are basic after 7 doses above clothes
It disappears.
Case two: thunder so-and-so, male, 68 years old, the Yanan City village He Zhuanping Zhen He Zhuan Ping 201, admission number 242245
The first visit time: on July 10th, 2017.
Main suit: making a definite diagnosis lung cancer more than January, spits blood 2 days.
Present illness history: there is cough without obvious inducement before January, coughs up phlegm in patient, and companioned with headache, shortness of breath are examined in conjunction with coherence check
Break as malignant tumor of lung (small cell carcinoma), carry out 1 period chemotherapeutic drug therapy, and chemotherapy is the specific scheme is that Etoposide (d1-
D3), cis-platinum (d1-d3), it is uncomfortable to occur Nausea and vomiting, stomach duct and abdomen after chemotherapy, after taking orally (specifically unknown) treatment of related drugs, disease
Shape is slightly alleviated.Patient spits blood without obvious inducement before 2 days, and color is scarlet, measure about 10ml, now for ask traditional Chinese medicine treatment come then just
It examines.Symptoms include: Nausea and vomiting, hiccup, stomach duct and abdomen are uncomfortable, cough, cough up a small amount of white viscous phlegm, cough up phlegm still sharp, blood-stained sputum silk, uncomfortable in chest, gas
It is short, it is out of strength, receive food can, night is not general, urine tune, and stool is dry.Dark tongue quality, tongue fur is white, wiry and rolling pulse.
Past medical history: lacunar infarction 1 year.
Tcm diagnosis: internal medicine carninomatosis, card belong to asthenia of pulmonosplenic qi, gallbladder stomach discord card.
Doctor trained in Western medicine diagnosis: 1, malignant tumor of lung (small cell carcinoma)；2, lacunar infarction.
Therapy: help lung spleen, stomach function regulating cholagogue.
Chinese medicine: half particle of reed grass temperature, specific medication are as follows: pinellia 15g, rhizoma zingiberis 15g, Exocarpium Citri Rubrum 15g, Poria cocos 15g, Fructus Aurantii
12g, wrinkled giant hyssop 15g, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice 4g, stir-baked RADIX SCUTELLARIAE with yellow rice wine 5g, reed root 30g, caulis bambusae in taenian 12g, perilla leaf 9g, Radix Codonopsis 15g, licorice 6g.3 doses, water
It takes after mixing it with water, day is one, takes in two times.
Reexamination time: on July 13rd, 2017
Tell that Nausea and vomiting, hiccup, stomach duct and abdomen malaise symptoms are alleviated after 3 doses of patient's medication, cough, shortness of breath mitigate, without blood in phlegm
Silk, receive food can, night is not general, and two just adjust.Dark tongue quality, tongue fur is white, wiry and rolling pulse.
Chinese medicine: half particle of reed grass temperature, specific medication are as follows: pinellia 15g, rhizoma zingiberis 15g, Exocarpium Citri Rubrum 15g, Poria cocos 15g, Fructus Aurantii
12g, wrinkled giant hyssop 15g, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice 4g, stir-baked RADIX SCUTELLARIAE with yellow rice wine 5g, reed root 30g, caulis bambusae in taenian 12g, perilla leaf 9g, Radix Codonopsis 15g, licorice 6g.7 doses, water
It takes after mixing it with water, day is one, takes in two times.
Pay a return visit: patient tells that alimentary canals, the respiratory tract malaise symptoms such as Nausea and vomiting, cough, shortness of breath are basic after 7 doses above clothes
It disappears.
Case three: Zheng, male, 66 years old, the Xi'an City, Shanxi Province Lianhu District mill Yi Min, admission number 2640596
The first visit time: on May 24th, 2018.
Main suit: malignant tumor of lung is made a definite diagnosis more than January.
Present illness history: patient coughs in cause more than January, coughs up a small amount of white viscous phlegm, dry throat, pharyngalgia, shortness of breath, asthma, sour regurgitation, burning
The heart is diagnosed as malignant tumor of lung (gland cancer) in conjunction with coherence check, and carry out 1 period chemotherapeutic drug therapy, chemotherapeutics concrete scheme
Are as follows: docetaxel 120mg (d1), cis-platinum 40mg (d1-d3), it is uncomfortable to occur Nausea and vomiting, stomach duct and abdomen after chemotherapy, takes orally Related Drug
After (specifically unknown) treatment of object, symptom is not alleviated, now to ask traditional Chinese medicine treatment to go to a doctor then.Symptoms include: Nausea and vomiting, hiccup, gastral cavity
Abdomen is uncomfortable, and paroxysmal cough coughs up a small amount of white viscous phlegm, uncomfortable in chest, shortness of breath, asthma, pectoralgia when cough play, out of strength, receives difference, and night is not general,
Urine tune is defecated shapeless.Tongue nature is light dark, and tongue fur is white, and veins string is slow.
Past medical history: the past body is strong.
Tcm diagnosis: internal medicine carninomatosis, card belong to asthenia of pulmonosplenic qi, gallbladder stomach discord card；
Doctor trained in Western medicine diagnosis: malignant tumor of lung (gland cancer).
Therapy: help lung spleen, stomach function regulating cholagogue.
Chinese medicine: half particle of reed grass temperature, specific medication are as follows: pinellia 15g, rhizoma zingiberis 15g, Exocarpium Citri Rubrum 15g, Poria cocos 15g, Fructus Aurantii
12g, wrinkled giant hyssop 15g, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice 4g, stir-baked RADIX SCUTELLARIAE with yellow rice wine 5g, reed root 30g, caulis bambusae in taenian 12g, perilla leaf 9g, Radix Codonopsis 15g, licorice 6g.3 doses, water
It takes after mixing it with water, day is one, takes in two times.
Reexamination time: on May 27th, 2018
Patient tells Nausea and vomiting, hiccup, the alleviation of stomach duct and abdomen malaise symptoms after 3 doses of medication, and cough, asthma mitigate, out of strength slow
Solution, food of receiving is general, night stop can, two just adjust, and tongue nature is light dark, and tongue fur is white, wiry and rolling pulse.
Chinese medicine: half particle of reed grass temperature, specific medication are as follows: pinellia 15g, rhizoma zingiberis 15g, Exocarpium Citri Rubrum 15g, Poria cocos 15g, Fructus Aurantii
12g, wrinkled giant hyssop 15g, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice 4g, stir-baked RADIX SCUTELLARIAE with yellow rice wine 5g, reed root 30g, caulis bambusae in taenian 12g, perilla leaf 9g, Radix Codonopsis 15g, licorice 6g.7 doses, water
It takes after mixing it with water, day is one, takes in two times.
Pay a return visit: patient tells that alimentary canals, the respiratory tract malaise symptoms such as Nausea and vomiting, cough, asthma are basic after 7 doses above clothes
It disappears.
The above, only presently preferred embodiments of the present invention, not to the present invention make in any form with substantial limit
System, all those skilled in the art, without departing from the scope of the present invention, when using disclosed above skill
Art content, and the equivalent variations for a little variation, modification and evolution made, are equivalent embodiment of the invention；Meanwhile it is all according to
According to the variation, modification and evolution of substantial technological any equivalent variations to the above embodiments of the invention, this is still fallen within
In the range of the technical solution of invention.
Claims (6)
1. a kind of Chinese medicine composition for treating nausea and vomiting caused by chemotherapy, which is characterized in that the Chinese medicine composition is by following heavy
Measure the bulk pharmaceutical chemicals composition of part: 6~15 parts of pinellia, 10~15 parts of rhizoma zingiberis, 6~15 parts of Huajuhong, PORIA ALBA 10~15 part, meter
3~12 parts of swill Fructus Aurantii, 10~15 parts of Pogostemon cablin, 2~4 parts of prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, 3~5 parts of stir-baked RADIX SCUTELLARIAE with yellow rice wine, 15~30 parts of reed root, caulis bambusae in taenian 5~12
Part, 5~9 parts of perilla leaf, 9~15 parts of RADIX CODONOPSIS PILOSULAE from Shanxi of China and 2~6 parts of licorice.
2. Chinese medicine composition according to claim 1, which is characterized in that the parts by weight of each bulk pharmaceutical chemicals are as follows: pinellia
15 parts, 15 parts of rhizoma zingiberis, 15 parts of Huajuhong, 15 12 parts of part, meter swill Fructus Aurantii of PORIA ALBA, 15 parts of Pogostemon cablin, 4 parts of prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, wine Huang
5 parts of a kind of reed mentioned in ancient books, 30 parts of reed root, 12 parts of caulis bambusae in taenian, 9 parts of perilla leaf, 15 parts of RADIX CODONOPSIS PILOSULAE from Shanxi of China and 6 parts of licorice.
3. Chinese medicine composition of any of claims 1 or 2 treats the application in nausea and vomiting drug caused by chemotherapy in preparation.
4. a kind of free decoction granule for treating nausea and vomiting caused by chemotherapy, which is characterized in that the free decoction granule
It is made of the single medicinal material granule of following weight parts: 6~15 parts of pinellia, 10~15 parts of rhizoma zingiberis, Huajuhong 6~15
Part, 10~15 3~12 parts of part, meter swill Fructus Aurantii of PORIA ALBA, 10~15 parts of Pogostemon cablin, 2~4 parts of prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, 3~5 parts of stir-baked RADIX SCUTELLARIAE with yellow rice wine, reed
15~30 parts of root, 5~12 parts of caulis bambusae in taenian, 5~9 parts of perilla leaf, 9~15 parts of RADIX CODONOPSIS PILOSULAE from Shanxi of China and 2~6 parts of licorice.
5. free decoction granule according to claim 1, which is characterized in that the weight of each single medicinal material granule
Measure part are as follows: 15 parts of pinellia, 15 parts of rhizoma zingiberis, 15 parts of Huajuhong, 15 12 parts of part, meter swill Fructus Aurantii of PORIA ALBA, 15 parts of Pogostemon cablin, ginger
4 parts of the coptis, 5 parts of stir-baked RADIX SCUTELLARIAE with yellow rice wine, 30 parts of reed root, 12 parts of caulis bambusae in taenian, 9 parts of perilla leaf, 15 parts of RADIX CODONOPSIS PILOSULAE from Shanxi of China and 6 parts of licorice.
6. free decoction granule described in claim 4 or 5 treats the application in nausea and vomiting drug caused by chemotherapy in preparation.
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| CN114366790A (en) * | 2022-01-27 | 2022-04-19 | 冯利 | Traditional Chinese medicine composition for preventing and treating tumor and treating after-appetite loss and gastrointestinal reaction |
| CN114949135A (en) * | 2022-06-21 | 2022-08-30 | 浙江省人民医院 | Traditional Chinese medicine composition for treating digestive tract reaction after chemotherapy and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110664947A (en) * | 2019-10-23 | 2020-01-10 | 赵莉 | Traditional Chinese medicine composition for stopping vomiting and preparation method thereof |
| CN114366790A (en) * | 2022-01-27 | 2022-04-19 | 冯利 | Traditional Chinese medicine composition for preventing and treating tumor and treating after-appetite loss and gastrointestinal reaction |
| CN114366790B (en) * | 2022-01-27 | 2023-03-14 | 冯利 | Traditional Chinese medicine composition for preventing and treating anorexia and gastrointestinal reaction after tumor treatment |
| CN114949135A (en) * | 2022-06-21 | 2022-08-30 | 浙江省人民医院 | Traditional Chinese medicine composition for treating digestive tract reaction after chemotherapy and preparation method thereof |
| CN114949135B (en) * | 2022-06-21 | 2023-09-12 | 浙江省人民医院 | Traditional Chinese medicine composition for treating digestive tract reaction after chemotherapy and preparation method thereof |
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