CN109662961A - 用于改善认知功能的方法和组合物 - Google Patents

用于改善认知功能的方法和组合物 Download PDF

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Publication number
CN109662961A
CN109662961A CN201811403097.5A CN201811403097A CN109662961A CN 109662961 A CN109662961 A CN 109662961A CN 201811403097 A CN201811403097 A CN 201811403097A CN 109662961 A CN109662961 A CN 109662961A
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CN
China
Prior art keywords
base
group
oxo
methyl
alkyl
Prior art date
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Pending
Application number
CN201811403097.5A
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English (en)
Chinese (zh)
Inventor
M·加拉格尔
R·哈伯曼
M·T·寇
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Johns Hopkins University
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Johns Hopkins University
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Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of CN109662961A publication Critical patent/CN109662961A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
CN201811403097.5A 2011-02-09 2012-02-09 用于改善认知功能的方法和组合物 Pending CN109662961A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161441251P 2011-02-09 2011-02-09
US61/441,251 2011-02-09
CN201280014797XA CN103476255A (zh) 2011-02-09 2012-02-09 用于改善认知功能的方法和组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280014797XA Division CN103476255A (zh) 2011-02-09 2012-02-09 用于改善认知功能的方法和组合物

Publications (1)

Publication Number Publication Date
CN109662961A true CN109662961A (zh) 2019-04-23

Family

ID=46638963

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201811403097.5A Pending CN109662961A (zh) 2011-02-09 2012-02-09 用于改善认知功能的方法和组合物
CN201280014797XA Pending CN103476255A (zh) 2011-02-09 2012-02-09 用于改善认知功能的方法和组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201280014797XA Pending CN103476255A (zh) 2011-02-09 2012-02-09 用于改善认知功能的方法和组合物

Country Status (9)

Country Link
US (2) US20120214859A1 (https=)
EP (2) EP2672822A4 (https=)
JP (7) JP2014505108A (https=)
CN (2) CN109662961A (https=)
AU (6) AU2012214303A1 (https=)
BR (1) BR112013020283A2 (https=)
CA (1) CA2826765C (https=)
RU (1) RU2665021C2 (https=)
WO (1) WO2012109491A1 (https=)

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CN115517682A (zh) * 2022-11-25 2022-12-27 四川大学华西医院 基于胃肠电信号的认知功能障碍预测系统及构建方法

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AU2018208662B2 (en) * 2012-11-14 2020-07-23 The Johns Hopkins University Methods and Compositions for Treating Schizophrenia
US20140206667A1 (en) * 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
US20160030391A1 (en) * 2013-03-15 2016-02-04 The Johns Hopkins University Methods and compositions for improving cognitive function
WO2014144663A1 (en) * 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
AU2014228512A1 (en) 2013-03-15 2015-10-01 Agenebio, Inc. Methods and compositions for improving cognitive function
HUE053734T2 (hu) 2014-01-21 2021-07-28 Janssen Pharmaceutica Nv 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait tartalmazó kombinációk és alkalmazásuk
KR20220049612A (ko) 2014-01-21 2022-04-21 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
CA2986598C (en) 2015-05-22 2023-09-26 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
US20220354807A1 (en) * 2019-09-30 2022-11-10 Xiamen University Use of valeric acid derivative in treatment of down's syndrome
WO2023183623A1 (en) 2022-03-25 2023-09-28 Regenxbio Inc. Dominant-negative tumor necrosis factor alpha adeno-associated virus gene therapy
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

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WO2010044878A1 (en) * 2008-10-16 2010-04-22 The Johns Hopkins University Methods and compositions for improving cognitive function
CN102905532A (zh) * 2010-02-09 2013-01-30 约翰斯.霍普金斯大学 用于改善认知功能的方法和组合物

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115517682A (zh) * 2022-11-25 2022-12-27 四川大学华西医院 基于胃肠电信号的认知功能障碍预测系统及构建方法
CN115517682B (zh) * 2022-11-25 2023-01-31 四川大学华西医院 基于胃肠电信号的认知功能障碍预测系统及构建方法

Also Published As

Publication number Publication date
US20120214859A1 (en) 2012-08-23
EP2672822A4 (en) 2014-08-27
JP2020079318A (ja) 2020-05-28
BR112013020283A2 (pt) 2016-07-19
JP2014505108A (ja) 2014-02-27
AU2012214303A1 (en) 2013-09-12
CA2826765C (en) 2021-04-06
RU2018129580A3 (https=) 2022-03-25
AU2021200325A1 (en) 2021-03-18
US20230033195A1 (en) 2023-02-02
EP2672822A1 (en) 2013-12-18
JP2016172772A (ja) 2016-09-29
AU2021200325B2 (en) 2022-07-28
CA2826765A1 (en) 2012-08-16
AU2022221492A1 (en) 2022-09-22
CN103476255A (zh) 2013-12-25
AU2016202670A1 (en) 2016-05-19
JP2023126654A (ja) 2023-09-07
JP2018100305A (ja) 2018-06-28
RU2665021C2 (ru) 2018-08-24
RU2018129580A (ru) 2019-03-20
AU2019268069A1 (en) 2019-12-12
AU2018201303A1 (en) 2018-03-15
JP2021175759A (ja) 2021-11-04
RU2013141155A (ru) 2015-03-20
EP3400934A1 (en) 2018-11-14
JP2025109773A (ja) 2025-07-25
WO2012109491A1 (en) 2012-08-16

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