CN109649746B - Preparation process and production equipment of three-layer co-extrusion glucose infusion soft bag - Google Patents

Preparation process and production equipment of three-layer co-extrusion glucose infusion soft bag Download PDF

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Publication number
CN109649746B
CN109649746B CN201811596002.6A CN201811596002A CN109649746B CN 109649746 B CN109649746 B CN 109649746B CN 201811596002 A CN201811596002 A CN 201811596002A CN 109649746 B CN109649746 B CN 109649746B
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China
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layer
double
canning
assembly
bag
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CN109649746A (en
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张俊锋
徐永东
饶欣欣
王雷
程洋
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Zhejiang Dubang Pharmaceutical Co ltd
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Zhejiang Dubang Pharmaceutical Co ltd
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B43/00Forming, feeding, opening or setting-up containers or receptacles in association with packaging
    • B65B43/04Forming flat bags from webs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/04Methods of, or means for, filling the material into the containers or receptacles

Abstract

The invention relates to a preparation process and production equipment of a three-layer co-extrusion glucose infusion soft bag, which is characterized by comprising the following steps of: the automatic bag filling machine comprises a single-layer bag making assembly, a double-layer bag making assembly, a canning assembly, a sealing assembly, a discharging assembly, a first-stage transfer assembly, a second-stage transfer assembly and a control cabinet, wherein the single-layer bag making assembly, the double-layer bag making assembly, the canning assembly, the sealing assembly, the discharging assembly, the first-stage transfer assembly, the second-stage transfer assembly and the control cabinet are sequentially arranged; the process comprises the following steps: preparing soft bags, preparing auxiliary materials and canning the soft bags; the invention has the beneficial effects that: the glucose transfusion soft bag with the double-layer film material can be prepared, and more favorable guarantee can be effectively provided for the glucose transfusion in the glucose transfusion soft bag.

Description

Preparation process and production equipment of three-layer co-extrusion glucose infusion soft bag
Technical Field
The invention relates to the technical field of preparation of glucose infusion soft bags, in particular to a preparation process and production equipment of a three-layer co-extrusion glucose infusion soft bag.
Background
The glucose transfusion soft bag is a soft bag filled with a glucose medicament, the conventional glucose transfusion soft bag is only single-layer, when the glucose transfusion soft bag is damaged (such as cracks, broken holes and the like), the glucose medicament in the glucose transfusion soft bag is easy to leak, the possibility of waste exists, and if the glucose transfusion soft bag is damaged during transportation, the environment is polluted.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a preparation process and production equipment of a three-layer co-extrusion glucose infusion soft bag, and aims to solve the problems in the background technology.
The technical scheme of the invention is realized as follows: a preparation process of a three-layer co-extrusion glucose infusion soft bag is characterized by comprising the following steps: comprises the steps of soft bag preparation, auxiliary material preparation and soft bag canning;
the preparation method of the soft bag comprises the following steps:
a1 monolayer bag preparation: drawing the film, compounding and cutting the double film materials to form a single-layer bag;
a2 double-layer bag preparation: compounding the single-layer bags cut from the step A1 with a film material to form double-layer bags;
a3 mouth tube heat sealing: adding an opening tube to the double-layer bag in A2 to form a soft bag blank;
the preparation of the auxiliary materials comprises the following steps:
b1 weighing auxiliary materials: weighing 50 g of glucose and 0.14 g of medicinal charcoal by taking the bag as a unit;
b2, concentrating auxiliary materials: adding the glucose and the medicinal carbon weighed in the B1 into a concentration preparation tank, adding a proper amount of hydrochloric acid and water to 1000ml, heating, stirring for 15min, dissolving uniformly, decarburizing, filtering and transferring into a dilution preparation tank;
b3 diluting auxiliary materials: adding water for injection to full dose, stirring for 15min-20min, and detecting after the medicinal liquid is uniformly mixed;
b4 detection: introducing the liquid medicine in B3 into titanium filter with liquid medicine aperture of 0.65 μm, microporous filter with aperture of 0.45 μm and 0.22 μm, coarse filtering, fine filtering, and terminal filtering, and sending into canning area after passing inspection;
soft bag canning, which comprises the following steps:
c1 canning of auxiliary materials: filling the liquid medicine in the B4 into the soft bag blank in the A3;
c2 soft bag sealing: filling a sealing cover into the soft bag blank filled with the liquid medicine in the C1, and heating and sealing to form a transfusion soft bag;
c3 bag discharge: sterilizing the soft infusion bag, inspecting by using a lamp, boxing and delivering out of the warehouse.
In addition, the invention also discloses a production device of the three-layer co-extrusion glucose transfusion soft bag, which is characterized in that: the automatic bag filling machine comprises a single-layer bag making assembly, a double-layer bag making assembly, a canning assembly, a sealing assembly, a discharging assembly, a first-stage transfer assembly, a second-stage transfer assembly and a control cabinet, wherein the first-stage transfer assembly is used for transferring single-layer bags on the single-layer bag making assembly to the double-layer bag making assembly, the second-stage transfer assembly is used for transferring double-layer bags on the double-layer bag making assembly to the canning assembly, and the control cabinet is used for controlling the operation.
Preferably: the single-layer bag making assembly comprises a single-layer bag making rack, wherein a single-layer film feeding roller, a welding device, a cutting device and a transmission device which is arranged on one side of the single-layer film feeding roller, the welding device and the cutting device and is used for conveying a die body on the single-layer film feeding roller to the cutting device are sequentially arranged on the single-layer bag making rack; the welding device comprises a lower welding plate fixedly connected to the single-layer bag making machine frame and an upper welding plate which is arranged at the top of the lower welding plate in a clearance mode and is driven to lift through an air cylinder, a plurality of pairs of first welding rods are arranged on the end face, close to the lower welding plate, of the upper welding plate at equal intervals, and one ends, close to the transmission device, of the pairs of first welding rods are fixedly connected through second welding rods; the cutting device comprises a steering roller and a cutting device which is arranged on one side of the steering roller, far away from the single-layer upper film roller, at intervals and used for cutting the film material, wherein a cutting groove is axially formed in one side of the steering roller, close to the cutting device, the cutting device comprises a cutting shaft which is arranged at intervals with the steering roller and driven to rotate by a motor, and cutters used for cutting the film material are arranged on the outer wall of the cutting shaft at intervals in the circumferential direction; the conveying device comprises a first transmission chain which is arranged on the single-layer bag making rack, is far away from one side of the double-layer bag making assembly and drives the first transmission chain to do circular motion through a first rotating shaft, and a plurality of first clamping devices which are used for clamping film materials to move from the direction of the single-layer film feeding roller to the direction of the steering roller are arranged on the first transmission chain at equal intervals.
Preferably: the double-layer bag making assembly comprises a double-layer bag making rack, and a double-layer film feeding roller, a double-layer welding device, a double-layer cutting device, a mouth pipe heat sealing device and a conveying device for conveying double-layer bags are sequentially arranged on the double-layer bag making rack; the double-layer welding device comprises a double-layer lower welding plate fixedly connected to a double-layer bag making machine frame and a double-layer upper welding plate which is arranged above the double-layer lower welding plate in a clearance mode and driven to lift through an air cylinder, the end face, close to the double-layer lower welding plate, of the double-layer upper welding plate and the end face, close to the double-layer upper welding plate, of the double-layer lower welding plate are both obliquely arranged from one side, close to the single-layer bag making assembly, to the other side, a plurality of pairs of third welding rods are arranged on the end face, close to the double-layer lower welding plate, of the double-layer upper welding plate at intervals, a fourth welding rod is fixedly connected between the ends, far away from the transmission device, of the pairs of third welding rods, a welding frame is; the double-layer cutting device comprises a cutting platform fixedly connected to the double-layer bag making machine frame, a plurality of pairs of transmission gears arranged at two ends, above and below the cutting platform and transmission strips which are transmitted through each pair of transmission gears and rotate around the circumference of the cutting platform, wherein cutting lines for cutting the film material are fixedly connected between the transmission strips at equal intervals; the mouth pipe heat sealing device comprises a heat sealing platform fixedly connected with the double-layer bag making machine frame, a heat sealing groove and a pushing channel, wherein the heat sealing groove is formed in the end face of the top of the heat sealing platform and is close to one side of the transmission device, the pushing channel is communicated with the heat sealing groove and is used for providing a mouth pipe into the heat sealing groove, a heat sealing plate which is driven by an air cylinder and moves towards the direction of the heat sealing groove is arranged right above the heat sealing groove, and a plurality of heat sealing parts used for fixedly connecting the mouth pipe and the double-layer bag are arranged on; the conveying device comprises a second transmission chain which is arranged on one side of the double-layer bag making rack, away from the conveying device and drives the double-layer bag making rack to circularly move through a second rotating shaft, and a plurality of second clamping devices used for clamping the film materials to move towards the direction of the heat sealing platform from the double-layer upper film roller are arranged on the second transmission chain at equal intervals.
Preferably: the primary transfer assembly comprises a plurality of transfer plates which are arranged below the transmission device, positioned between the lower welding plate and the double-layer lower welding plate and in one-to-one correspondence with the welding frames, and a primary transfer device which is arranged on one side of the transfer plates away from the transmission device, wherein each transfer plate is obliquely and downwards arranged from one end close to the lower welding plate to one end away from the double-layer lower welding plate; the first-level transfer device comprises a plurality of transmission plates and a conveyor belt, wherein the transmission plates are fixedly connected to one side of the double-layer lower welding plate close to the transfer plate, one end of each transmission plate extends towards the direction of each welding frame, and the conveyor belt is arranged between the transfer plate and the transmission plates.
Preferably: the canning component comprises a canning platform, transmission guide wheels arranged at two ends of the canning platform, a transmission cloth belt which rotates around the circumferential motion of the outer wall of the canning platform through each transmission guide wheel, and a plurality of clamping blocks which are fixedly connected on the transmission cloth belt at intervals and used for clamping double-layer bags, wherein the top of the canning platform is fixedly connected with a canning area through a supporting part, the canning area comprises a canning plate fixedly connected with the supporting part and a liquid storage tank arranged above the canning plate at intervals, the canning plate is provided with a plurality of tank liquid channels penetrating from the top to the bottom, the top of each tank liquid channel is communicated with an electric valve, the other opening of each electric valve is communicated with the liquid storage tank through a liquid conveying pipe, one side of the canning plate is provided with a plurality of sliding grooves which correspond to and are communicated with the canning channels respectively, sliding rods are connected in the sliding grooves in a sliding manner, and one end of each sliding rod, which is far away from the canning channel, is positioned, the sliding plate that each slide bar is close to the equal fixedly connected with of one end of canning passageway and the laminating of canning passageway inner wall, the canning passageway is worn out from the bottom of canning passageway to the equal part of the ejection of compact mouth and each ejection of compact mouth of the bottom fixedly connected with of the inner wall laminating of canning passageway and each ejection of compact mouth of sliding plate, the transmission strap's one side fixedly connected with lift bar of buckling is kept away from to the grip block, and the other end of each lift bar of buckling all extends towards the slide bar direction and is equipped with the interval at this end of each lift bar of buckling and is equipped with the.
Preferably: the secondary transfer assembly comprises a rotating platform arranged between the conveying device and the canning platform and a secondary transfer device which is rotationally connected to the rotating platform and driven by a motor; the secondary transfer device comprises a transmission shaft fixedly connected with the output end of the motor, a plurality of transfer supports are fixedly connected to the outer wall of the transmission shaft at intervals in the circumferential direction, and a receiving frame used for receiving the double-layer bag falling off from the second clamping device is fixedly connected to the free end of each transfer support; when the transfer stand rotates, the receiving frame receives the double-layered bag detached from the second holding device and transports it to the holding block.
Preferably: the sealing assembly comprises a material conveying platform and a plurality of material storage cylinders, wherein the material conveying platform is arranged on one side of the filling area at intervals and is positioned above the filling platform, the material storage cylinders are used for storing sealing covers, the bottom of each material storage cylinder is fixedly connected with a vibrating screen, a plurality of material conveying channels are arranged on the material conveying platform, each material conveying channel is respectively communicated with each material storage cylinder, and the inner wall of each material storage cylinder extends spirally from the bottom to the top along the inner wall of the material storage cylinder to form vibrating channels communicated with each material conveying channel; the port that storage section of thick bamboo one end was kept away from to defeated material passageway is equipped with the play flitch that is used for restricting the activity of sealed lid, it all is located the grip block directly over and each goes out the flitch and all extends to the grip block direction to go out the flitch, and the free end of each play flitch all sets up with the grip block clearance, be equipped with in the play flitch and supply the activity of sealed piece and with the activity passageway of defeated material passageway intercommunication, and be equipped with the spacing portion that is used for restricting the activity of sealed piece in activity passageway and the junction of defeated material passageway, the top clearance of going out the flitch is equipped with and passes the activity passageway and make sealed lid and the fixed depression bar.
Preferably: the discharging assembly comprises a conveying belt which is arranged on one side of the canning platform, is far away from the secondary transfer assembly and is positioned below each clamping block.
Preferably: first clamping device and second clamping device all include respectively with first drive chain and second drive chain fixed connection's grip block and two vertical clearances locate on the grip block and through the tight piece of clamp of switch board control both mutual contacts of control cabinet or keeping away from.
The invention has the beneficial effects that: the single-layer bag is manufactured through the single-layer bag manufacturing assembly, the single-layer bag is sent into the double-layer bag manufacturing assembly to be reprocessed to produce the double-layer bag, the glucose infusion soft bag with the two layers of membrane materials is produced through the charging of the canning assembly and the sealing of the sealing assembly, when one layer is damaged, the glucose liquid medicine in the double-layer bag cannot flow out of the double-layer bag, so that the effective guarantee is provided for the transportation of the glucose infusion soft bag, and the pollution to the environment caused by the leakage of the glucose liquid medicine and the leakage in the transportation process can be avoided; the production principle is as follows: preparing a single-layer bag from a membrane material through a welding device, welding the membrane material and the membrane material through a primary assembly transfer paper double-layer welding device after cutting through a cutting device to prepare a double-layer bag, forming a double-layer bag mould blank after cutting through the double-layer cutting device, feeding the double-layer bag mould blank into a mouth pipe heat sealing device for mouth pipe installation, feeding the mouth pipe into a clamping block through a secondary transfer device after the mouth pipe is installed, canning the double-layer bag mould blank when the clamping block enters a filling area, and sealing the double-layer bag mould blank when the canning is finished and the sealing assembly is fed, so that a glucose infusion soft bag with the double-layer membrane material is prepared; it should be noted that: one end of the transmission plate, which is far away from the transmission sheet, can be positioned between the film materials, so that the single-layer bag can be smoothly fed between the film materials, and then the double-layer bag can be produced; and secondly, the single-layer bags can be positioned when being transferred through the welding frame, so that effective guarantee is provided for welding the double-layer bags.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
FIG. 1 is a schematic structural diagram of embodiment 1 of the present invention;
FIG. 2 is a schematic structural diagram of embodiment 2 of the present invention;
FIG. 3 is a schematic view of a single layer bag making assembly according to embodiment 2 of the present invention;
FIG. 4 is a schematic structural view of a double bag-making assembly in accordance with embodiment 2 of the present invention;
FIG. 5 is a schematic structural diagram of a primary transfer unit in embodiment 2 of the present invention;
FIG. 6 is a schematic view showing the construction of the canning assembly according to embodiment 2 of the present invention;
FIG. 7 is a schematic view showing a part of the structure of a canning zone in accordance with embodiment 2 of the present invention;
FIG. 8 is a partial schematic view of the buckling-restrained lifting bar according to embodiment 2 of the present invention;
FIG. 9 is a schematic structural diagram of a secondary transfer module according to embodiment 2 of the present invention;
FIG. 10 is a schematic structural diagram of a sealing assembly in embodiment 2 of the present invention;
fig. 11 is a schematic side view of a sealing assembly according to embodiment 2 of the present invention;
fig. 12 is a schematic structural diagram of a clamping device in embodiment 2 of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The invention discloses a preparation process of a three-layer co-extrusion glucose infusion soft bag, which comprises the steps of soft bag preparation, auxiliary material preparation and soft bag canning in a specific embodiment of the invention;
the preparation method of the soft bag comprises the following steps:
a1 monolayer bag preparation: drawing the film, compounding and cutting the double film materials to form a single-layer bag;
a2 double-layer bag preparation: compounding the single-layer bags cut from the step A1 with a film material to form double-layer bags;
a3 mouth tube heat sealing: adding an opening tube to the double-layer bag in A2 to form a soft bag blank;
the preparation of the auxiliary materials comprises the following steps:
b1 weighing auxiliary materials: weighing 50 g of glucose and 0.14 g of medicinal charcoal by taking the bag as a unit;
b2, concentrating auxiliary materials: adding the glucose and the medicinal carbon weighed in the B1 into a concentration preparation tank, adding a proper amount of hydrochloric acid and water to 1000ml, heating, stirring for 15min, dissolving uniformly, decarburizing, filtering and transferring into a dilution preparation tank;
b3 diluting auxiliary materials: adding water for injection to full dose, stirring for 15min, and detecting after the medicinal liquid is uniformly mixed;
b4 detection: introducing the liquid medicine in B3 into titanium filter with liquid medicine aperture of 0.65 μm, microporous filter with aperture of 0.45 μm and 0.22 μm, coarse filtering, fine filtering, and terminal filtering, and sending into canning area after passing inspection;
soft bag canning, which comprises the following steps:
c1 canning of auxiliary materials: filling the liquid medicine in the B4 into the soft bag blank in the A3;
c2 soft bag sealing: filling a sealing cover into the soft bag blank filled with the liquid medicine in the C1, and heating and sealing to form a transfusion soft bag;
c3 bag discharge: sterilizing the soft infusion bag, inspecting by using a lamp, boxing and delivering out of the warehouse.
Example 2
As shown in fig. 2 to 12, the present invention discloses a three-layer co-extrusion glucose soft infusion bag production apparatus, which comprises a single-layer bag making assembly 1, a double-layer bag making assembly 2, a canning assembly 3, a sealing assembly 4, a discharging assembly 5, a first-stage transfer assembly 6 for transferring a single-layer bag on the single-layer bag making assembly 1 to the double-layer bag making assembly 2, a second-stage transfer assembly 7 for transferring a double-layer bag on the double-layer bag making assembly 2 to the canning assembly 3, and a control cabinet for controlling the operation of the above components.
In the embodiment of the invention, the single-layer bag making assembly 1 comprises a single-layer bag making frame 10, wherein a single-layer film feeding roller 11, a welding device 12, a cutting device 13 and a conveying device 14 which is arranged on one side of the single-layer film feeding roller 10 and is used for conveying a mold body on the single-layer film feeding roller 11 to the cutting device 13 are sequentially arranged on the single-layer bag making frame; the welding device 12 comprises a lower welding plate 120 fixedly connected to the single-layer bag making machine frame 10 and an upper welding plate 121 arranged at the top of the lower welding plate 120 in a clearance manner and driven to lift by an air cylinder, a plurality of pairs of first welding rods 122 are arranged on the end surface of the upper welding plate 121 close to the lower welding plate 120 at equal intervals, and one ends of the pairs of first welding rods 122 close to the transmission device are fixedly connected through second welding rods 123; the cutting device 13 comprises a turning roller 130 and a cutting device 131 which is arranged at one side of the turning roller 130 far away from the single-layer upper film roller 11 at intervals and used for cutting the film, a cutting groove 1300 is axially arranged at one side of the turning roller 130 close to the cutting device 131, the cutting device 131 comprises a cutting shaft 1310 which is arranged at intervals with the turning roller 130 and is driven to rotate by a motor, and cutters 1311 used for cutting the film are arranged at intervals in the circumferential direction of the outer wall of the cutting shaft 1310; the conveying device 14 includes a first transmission chain 141 disposed on a side of the single-layer bag making frame 10 away from the double-layer bag making assembly 2 and driven by a first rotating shaft 140 to move circularly, and a plurality of first clamping devices 142 for clamping the film to move from the direction of the single-layer film feeding roller 11 to the direction of the turning roller 130 are disposed on the first transmission chain 141 at equal intervals.
In the embodiment of the invention, the double-layer bag making assembly 2 comprises a double-layer bag making frame 20, wherein a double-layer film feeding roller 21, a double-layer welding device 22, a double-layer cutting device 23, a mouth pipe heat sealing device 25 and a conveying device 24 for conveying double-layer bags are sequentially arranged on the double-layer bag making frame 20; the double-layer welding device 22 comprises a double-layer lower welding plate 220 fixedly connected to the double-layer bag making machine frame 20 and a double-layer upper welding plate 221 arranged above the double-layer lower welding plate 220 in a clearance mode and driven to ascend and descend through an air cylinder, the end face, close to the double-layer lower welding plate 220, of the double-layer upper welding plate 221 and the end face, close to the double-layer upper welding plate 221, of the double-layer lower welding plate 220 are both obliquely arranged from one side, close to the single-layer bag making assembly 1, to the other side, a plurality of pairs of third welding rods 222 are arranged on the end face, close to the double-layer lower welding plate 220, of the double-layer upper welding plate 221 at intervals, a fourth welding rod 223 is fixedly connected between the ends, far away from the transmission device 24, of each pair of third welding rods 222, a welding frame 224 is arranged on the end face, close to the; the double-layer cutting device 23 comprises a cutting platform 230 fixedly connected to the double-layer bag making machine frame 20, a plurality of pairs of transmission gears 231 arranged at the two ends, above and below the cutting platform 230 and transmission bars 232 which are transmitted by the transmission gears 231 and rotate around the cutting platform 230 in the circumferential direction, and cutting lines 233 for cutting the film are fixedly connected between the transmission bars 232 at equal intervals; the mouth pipe heat sealing device 25 comprises a heat sealing platform 250 fixedly connected with the double-layer bag making machine frame 20, a heat sealing groove 251 arranged on the top end face of the heat sealing platform 250 and close to one side of the transmission device 14, and a pushing channel 252 communicated with the heat sealing groove 251 and used for providing a mouth pipe into the heat sealing groove 251, a heat sealing plate 253 driven by an air cylinder and moving towards the direction of the heat sealing groove 251 is arranged right above the heat sealing groove 251, and a plurality of heat sealing parts 2530 used for fixedly connecting the mouth pipe with the double-layer bag are arranged on the heat sealing plate 253; the conveying device 24 includes a second transmission chain 241 disposed on one side of the double-layer bag making frame 20 away from the conveying device 144 and driven to move circularly by a second rotating shaft 240, and a plurality of second clamping devices 242 for clamping the film material to move from the double-layer film feeding roller 21 to the heat sealing platform 250 are disposed on the second transmission chain 241 at equal intervals.
In the embodiment of the present invention, the primary transfer assembly 6 includes a plurality of transfer plates 60 disposed below the transmission device 14 and between the lower welding plate 120 and the double-layer lower welding plate 220 and corresponding to the welding frames 224 one by one, and a primary transfer device 61 disposed on a side of the transfer plates 60 away from the transmission device 14, wherein each transfer plate 60 is disposed in an inclined downward manner from a side close to the lower welding plate 120 to a side away from the double-layer lower welding plate 220; the primary transfer device 61 includes a plurality of transmission plates 610 fixedly connected to one side of the double-layer lower welding plate 220 close to the transfer plate 60 and having one end extending toward each welding frame 224, and a conveyor belt 611 disposed between the transfer plate 60 and the transmission plates 610.
In the embodiment of the present invention, the filling assembly 3 includes a filling platform 30, transmission guide wheels 31 disposed at two ends of the filling platform 30, transmission cloth belts 32 rotating through the transmission guide wheels 31 and moving circumferentially around the outer wall of the filling platform 30, and a plurality of holding blocks 33 fixedly connected to the transmission cloth belts 32 at equal intervals and used for holding double-layer bags, the top of the filling platform 30 is fixedly connected to a filling area 35 through a support 34, the filling area 35 includes a filling plate 350 fixedly connected to the support 34 and a liquid storage tank 351 disposed above the filling plate 350 at intervals, the filling plate 351 is provided with a plurality of liquid tank passages 352 penetrating from top to bottom, the top of each liquid tank passage 352 is communicated with an electric valve 353, another opening of each 353 is communicated with the liquid storage tank 352 through an electric valve 354, one side of the filling plate 350 is provided with a plurality of sliding grooves 3500 respectively corresponding to and communicating with each filling passage 352, and a sliding rod 3501 is slidably connected in each sliding groove 3500, one end of each sliding rod 3501, which is far away from the canning channel 352, is positioned outside the sliding groove 3500, one end of each sliding rod 3501, which is close to the canning channel 352, is fixedly connected with a sliding plate 3502, which is attached to the inner wall of the canning channel 352, the bottom of each sliding plate 3502 is fixedly connected with a discharge nozzle 3503, which is attached to the inner wall of the canning channel 352, and all parts of each discharge nozzle 3503 penetrate out of the canning channel 352 from the bottom of the canning channel 352, one side of the clamping block 33, which is far away from the transmission cloth belt 32, is fixedly connected with a bending lifting rod 33a, and the other end of each bending lifting rod 33a extends towards the direction of the sliding rod 3501, and a lifting convex part 33b is.
In the embodiment of the present invention, the secondary transfer assembly 7 includes a rotating platform 70 disposed between the transporting device 24 and the canning platform 30, and a secondary transfer device 71 rotatably connected to the rotating platform 70 and driven by a motor; the secondary transfer device 71 comprises a transmission shaft 710 fixedly connected with the output end of the motor, a plurality of transfer brackets 711 are fixedly connected to the outer wall of the transmission shaft 710 at intervals in the circumferential direction, and a receiving frame 712 for receiving the double-layer bag falling off from the second clamping device 242 is fixedly connected to the free end of each transfer bracket 711; when the transfer bracket 711 rotates, the receiving frame 712 receives the double-layered bag peeled off from the second holding device 242 and transports it to the holding block 33.
In the embodiment of the present invention, the sealing assembly 4 includes a feeding platform 40 spaced at the side of the filling area 350 and located above the filling platform 30, and a plurality of storage cylinders 41 for storing sealing caps, the bottom of the storage cylinder 41 is fixedly connected with a vibrating screen 42, the feeding platform 40 is provided with a plurality of feeding channels 400, each feeding channel 400 is respectively communicated with each storage cylinder 41, and the inner wall of the storage cylinder 41 extends spirally from the bottom to the top along the inner wall thereof to form a vibrating channel 410 communicated with each feeding channel 400; defeated material passageway 400 is kept away from the port of 41 one end of storage cylinder and is equipped with the discharge plate 43 that is used for restricting the activity of sealed lid, discharge plate 43 all is located grip block 33 directly over and each discharge plate 43 all extends to grip block 33 direction, and the free end of each discharge plate 43 all sets up with grip block 33 clearance, be equipped with in the discharge plate 43 and supply the activity of sealed piece and with the movable channel 430 of defeated material passageway 400 intercommunication, and be equipped with the spacing portion 4301 that is used for restricting the activity of sealed piece in movable channel 430 and the junction of defeated material passageway 400, the top clearance of discharge plate 43 is equipped with and passes movable channel 430 and make sealed lid and the fixed depression bar 4302 of double-deck bag through cylinder drive.
In the present embodiment, the discharging assembly 5 includes a conveyor belt 50 disposed on a side of the canning platform 30 away from the secondary transfer assembly 7 and below each clamping block 33.
In the embodiment of the present invention, each of the first clamping device 142 and the second clamping device 242 includes a clamping plate 800 fixedly connected to the first transmission chain 141 and the second transmission chain 241, and two clamping blocks 801 longitudinally spaced apart from each other and disposed on the clamping plate 800, and controlled by the control cabinet to contact with or separate from each other.
In the embodiment of the invention, the single-layer bag making assembly 1, the double-layer bag making assembly 2, the canning assembly 3, the sealing assembly 4, the discharging assembly 5, the first-stage transfer assembly 6 for transferring the single-layer bags on the single-layer bag making assembly 1 to the double-layer bag making assembly 2, and the second-stage transfer assembly 7 for transferring the double-layer bags on the double-layer bag making assembly 2 to the canning assembly 3 can be electrically connected with the control cabinet through sensors, and all the assemblies are controlled through a central control unit arranged in the control cabinet.
The invention has the beneficial effects that: the single-layer bag is manufactured through the single-layer bag manufacturing assembly, the single-layer bag is sent into the double-layer bag manufacturing assembly to be reprocessed to produce the double-layer bag, the glucose infusion soft bag with the two layers of membrane materials is produced through the charging of the canning assembly and the sealing of the sealing assembly, when one layer is damaged, the glucose liquid medicine in the double-layer bag cannot flow out of the double-layer bag, so that the effective guarantee is provided for the transportation of the glucose infusion soft bag, and the pollution to the environment caused by the leakage of the glucose liquid medicine and the leakage in the transportation process can be avoided; the production principle is as follows: preparing a single-layer bag from a membrane material through a welding device, welding the membrane material and the membrane material through a primary assembly transfer paper double-layer welding device after cutting through a cutting device to prepare a double-layer bag, forming a double-layer bag mould blank after cutting through the double-layer cutting device, feeding the double-layer bag mould blank into a mouth pipe heat sealing device for mouth pipe installation, feeding the mouth pipe into a clamping block through a secondary transfer device after the mouth pipe is installed, canning the double-layer bag mould blank when the clamping block enters a filling area, and sealing the double-layer bag mould blank when the canning is finished and the sealing assembly is fed, so that a glucose infusion soft bag with the double-layer membrane material is prepared; it should be noted that: one end of the transmission plate, which is far away from the transmission sheet, can be positioned between the film materials, so that the single-layer bag can be smoothly fed between the film materials, and then the double-layer bag can be produced; secondly, the single-layer bags can be positioned when being transferred through the welding frame, so that effective guarantee is provided for welding the double-layer bags; (third), each subassembly passes through the sensor and is connected with the switch board electricity, can realize the timely control to each subassembly, for example: when canning, the motion of transmission strap can be suspended, and the operation is continued after the canning is finished, and simultaneously, the cutting can also be stopped, thereby ensuring smooth cutting.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (6)

1. A preparation process of a three-layer co-extrusion glucose infusion soft bag is characterized by comprising the following steps: comprises the steps of soft bag preparation, auxiliary material preparation and soft bag canning;
the preparation method of the soft bag comprises the following steps:
a1 monolayer bag preparation: drawing the film, compounding and cutting the double film materials to form a single-layer bag;
a2 double-layer bag preparation: compounding the single-layer bags cut from the step A1 with a film material to form double-layer bags;
a3 mouth tube heat sealing: adding an opening tube to the double-layer bag in A2 to form a soft bag blank;
the preparation of the auxiliary materials comprises the following steps:
b1 weighing auxiliary materials: weighing 50 g of glucose and 0.14 g of medicinal charcoal by taking the bag as a unit;
b2, concentrating auxiliary materials: adding the glucose and the medicinal carbon weighed in the B1 into a concentration preparation tank, adding a proper amount of hydrochloric acid and water to 1000ml, heating, stirring for 15min, dissolving uniformly, decarburizing, filtering and transferring into a dilution preparation tank;
b3 diluting auxiliary materials: adding water for injection to full dose, stirring for 15min-20min, and detecting after the medicinal liquid is uniformly mixed;
b4 detection: introducing the liquid medicine in B3 into titanium filter with liquid medicine aperture of 0.65 μm, microporous filter with aperture of 0.45 μm and 0.22 μm, coarse filtering, fine filtering, and terminal filtering, and sending into canning area after passing inspection;
soft bag canning, which comprises the following steps:
c1 canning of auxiliary materials: filling the liquid medicine in the B4 into the soft bag blank in the A3;
c2 soft bag sealing: filling a sealing cover into the soft bag blank filled with the liquid medicine in the C1, and heating and sealing to form a transfusion soft bag;
c3 bag discharge: sterilizing, inspecting by a lamp, boxing and delivering the soft infusion bag out of the warehouse;
the production equipment applied to the steps of soft bag preparation, auxiliary material preparation and soft bag canning comprises a single-layer bag making assembly, a double-layer bag making assembly, a canning assembly, a sealing assembly, a discharging assembly, a first-stage transfer assembly, a second-stage transfer assembly and a control cabinet, wherein the first-stage transfer assembly is used for transferring a single-layer bag on the single-layer bag making assembly to the double-layer bag making assembly, the second-stage transfer assembly is used for transferring a double-layer bag on the double-layer bag making assembly to the canning assembly, and the control cabinet is used;
the single-layer bag making assembly comprises a single-layer bag making rack, wherein a single-layer film feeding roller, a welding device, a cutting device and a transmission device which is arranged on one side of the single-layer film feeding roller, the welding device and the cutting device and is used for conveying a die body on the single-layer film feeding roller to the cutting device are sequentially arranged on the single-layer bag making rack; the welding device comprises a lower welding plate fixedly connected to the single-layer bag making machine frame and an upper welding plate which is arranged at the top of the lower welding plate in a clearance mode and is driven to lift through an air cylinder, a plurality of pairs of first welding rods are arranged on the end face, close to the lower welding plate, of the upper welding plate at equal intervals, and one ends, close to the transmission device, of the pairs of first welding rods are fixedly connected through second welding rods; the cutting device comprises a steering roller and a cutting device which is arranged on one side of the steering roller, far away from the single-layer upper film roller, at intervals and used for cutting the film material, wherein a cutting groove is axially formed in one side of the steering roller, close to the cutting device, the cutting device comprises a cutting shaft which is arranged at intervals with the steering roller and driven to rotate by a motor, and cutters used for cutting the film material are arranged on the outer wall of the cutting shaft at intervals in the circumferential direction; the conveying device comprises a first transmission chain which is arranged on one side of the single-layer bag making rack, away from the double-layer bag making assembly and is driven to circularly move by a first rotating shaft, and a plurality of first clamping devices which are used for clamping the film to move from the direction of the single-layer film feeding roller to the direction of the steering roller are arranged on the first transmission chain at equal intervals;
the double-layer bag making assembly comprises a double-layer bag making rack, and a double-layer film feeding roller, a double-layer welding device, a double-layer cutting device, a mouth pipe heat sealing device and a conveying device for conveying double-layer bags are sequentially arranged on the double-layer bag making rack; the double-layer welding device comprises a double-layer lower welding plate fixedly connected to a double-layer bag making machine frame and a double-layer upper welding plate which is arranged above the double-layer lower welding plate in a clearance mode and driven to lift through an air cylinder, the end face, close to the double-layer lower welding plate, of the double-layer upper welding plate and the end face, close to the double-layer upper welding plate, of the double-layer lower welding plate are both obliquely arranged from one side, close to the single-layer bag making assembly, to the other side, a plurality of pairs of third welding rods are arranged on the end face, close to the double-layer lower welding plate, of the double-layer upper welding plate at intervals, a fourth welding rod is fixedly connected between the ends, far away from the transmission device, of the pairs of third welding rods, a welding frame is; the double-layer cutting device comprises a cutting platform fixedly connected to the double-layer bag making machine frame, a plurality of pairs of transmission gears arranged at two ends, above and below the cutting platform and transmission strips which are transmitted through each pair of transmission gears and rotate around the circumference of the cutting platform, wherein cutting lines for cutting the film material are fixedly connected between the transmission strips at equal intervals; the mouth pipe heat sealing device comprises a heat sealing platform fixedly connected with the double-layer bag making machine frame, a heat sealing groove and a pushing channel, wherein the heat sealing groove is formed in the end face of the top of the heat sealing platform and is close to one side of the transmission device, the pushing channel is communicated with the heat sealing groove and is used for providing a mouth pipe into the heat sealing groove, a heat sealing plate which is driven by an air cylinder and moves towards the direction of the heat sealing groove is arranged right above the heat sealing groove, and a plurality of heat sealing parts used for fixedly connecting the mouth pipe and the double-layer bag are arranged on; the conveying device comprises a second transmission chain which is arranged on one side of the double-layer bag making rack, away from the conveying device and is driven to circularly move by a second rotating shaft, and a plurality of second clamping devices used for clamping the film material to move from the double-layer film feeding roller to the direction of the heat sealing platform are arranged on the second transmission chain at equal intervals;
the canning component comprises a canning platform, transmission guide wheels arranged at two ends of the canning platform, a transmission cloth belt which rotates around the circumferential motion of the outer wall of the canning platform through each transmission guide wheel, and a plurality of clamping blocks which are fixedly connected on the transmission cloth belt at intervals and used for clamping double-layer bags, wherein the top of the canning platform is fixedly connected with a canning area through a supporting part, the canning area comprises a canning plate fixedly connected with the supporting part and a liquid storage tank arranged above the canning plate at intervals, the canning plate is provided with a plurality of tank liquid channels penetrating from the top to the bottom, the top of each tank liquid channel is communicated with an electric valve, the other opening of each electric valve is communicated with the liquid storage tank through a liquid conveying pipe, one side of the canning plate is provided with a plurality of sliding grooves which correspond to and are communicated with the canning channels respectively, sliding rods are connected in the sliding grooves in a sliding manner, and one end of each sliding rod, which is far away from the canning channel, is positioned, the sliding plate that each slide bar is close to the equal fixedly connected with of one end of canning passageway and the laminating of canning passageway inner wall, the canning passageway is worn out from the bottom of canning passageway to the equal part of the ejection of compact mouth and each ejection of compact mouth of the bottom fixedly connected with of the inner wall laminating of canning passageway and each ejection of compact mouth of sliding plate, the transmission strap's one side fixedly connected with lift bar of buckling is kept away from to the grip block, and the other end of each lift bar of buckling all extends towards the slide bar direction and is equipped with the interval at this end of each lift bar of buckling and is equipped with the.
2. The preparation process of the three-layer co-extrusion glucose transfusion soft bag according to claim 1, which is characterized in that: the primary transfer assembly comprises a plurality of transfer plates which are arranged below the transmission device, positioned between the lower welding plate and the double-layer lower welding plate and in one-to-one correspondence with the welding frames, and a primary transfer device which is arranged on one side of the transfer plates away from the transmission device, wherein each transfer plate is obliquely and downwards arranged from one end close to the lower welding plate to one end away from the double-layer lower welding plate; the first-level transfer device comprises a plurality of transmission plates and a conveyor belt, wherein the transmission plates are fixedly connected to one side of the double-layer lower welding plate close to the transfer plate, one end of each transmission plate extends towards the direction of each welding frame, and the conveyor belt is arranged between the transfer plate and the transmission plates.
3. The preparation process of the three-layer co-extrusion glucose transfusion soft bag according to claim 1, which is characterized in that: the secondary transfer assembly comprises a rotating platform arranged between the conveying device and the canning platform and a secondary transfer device which is rotationally connected to the rotating platform and driven by a motor; the secondary transfer device comprises a transmission shaft fixedly connected with the output end of the motor, a plurality of transfer supports are fixedly connected to the outer wall of the transmission shaft at intervals in the circumferential direction, and a receiving frame used for receiving the double-layer bag falling off from the second clamping device is fixedly connected to the free end of each transfer support; when the transfer stand rotates, the receiving frame receives the double-layered bag detached from the second holding device and transports it to the holding block.
4. The preparation process of the three-layer co-extrusion glucose transfusion soft bag according to the claim 1 or 3, which is characterized in that: the sealing assembly comprises a material conveying platform and a plurality of material storage cylinders, wherein the material conveying platform is arranged on one side of the filling area at intervals and is positioned above the filling platform, the material storage cylinders are used for storing sealing covers, the bottom of each material storage cylinder is fixedly connected with a vibrating screen, a plurality of material conveying channels are arranged on the material conveying platform, each material conveying channel is respectively communicated with each material storage cylinder, and the inner wall of each material storage cylinder extends spirally from the bottom to the top along the inner wall of the material storage cylinder to form vibrating channels communicated with each material conveying channel; the port that storage section of thick bamboo one end was kept away from to defeated material passageway is equipped with the play flitch that is used for restricting the activity of sealed lid, it all is located the grip block directly over and each goes out the flitch and all extends to the grip block direction to go out the flitch, and the free end of each play flitch all sets up with the grip block clearance, be equipped with in the play flitch and supply the activity of sealed piece and with the activity passageway of defeated material passageway intercommunication, and be equipped with the spacing portion that is used for restricting the activity of sealed piece in activity passageway and the junction of defeated material passageway, the top clearance of going out the flitch is equipped with and passes the activity passageway and make sealed lid and the fixed depression bar.
5. The preparation process of the three-layer co-extrusion glucose transfusion soft bag according to claim 4, which is characterized in that: the discharging assembly comprises a conveying belt which is arranged on one side of the canning platform, is far away from the secondary transfer assembly and is positioned below each clamping block.
6. The preparation process of the three-layer co-extrusion glucose transfusion soft bag according to claim 1, which is characterized in that: first clamping device and second clamping device all include respectively with first drive chain and second drive chain fixed connection's grip block and two vertical clearances locate on the grip block and through the tight piece of clamp of switch board control both mutual contacts of control cabinet or keeping away from.
CN201811596002.6A 2018-12-26 2018-12-26 Preparation process and production equipment of three-layer co-extrusion glucose infusion soft bag Active CN109649746B (en)

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978637A (en) * 1975-10-24 1976-09-07 Diamond Crystal Salt Company Method and apparatus for making packet assemblies
US4862675A (en) * 1986-02-18 1989-09-05 American National Can Company Packaging method
CN2450093Y (en) * 2000-11-16 2001-09-26 山东龙口凯祥有限公司 Double-layer fruit bag forming machine
JP2006232381A (en) * 2005-02-28 2006-09-07 Dainippon Printing Co Ltd Method and apparatus for sterile packaging
CN200939712Y (en) * 2006-08-15 2007-08-29 山东新华医疗器械股份有限公司 Complete set for producing molyolefine coextruded film powder/liquid dual-chamber soft transfusion bags
CN102642630A (en) * 2012-05-07 2012-08-22 山东新华医疗器械股份有限公司 Full-automatic bag making and filling and sealing machine of bag tail filling non-PVC membrane transfusion soft bag
CN203507132U (en) * 2013-06-03 2014-04-02 湖南科伦制药有限公司 Non-orifice type filling multilayered coextrusion membrane large soft transfusion bag
CN106692047A (en) * 2017-01-16 2017-05-24 浙江都邦药业股份有限公司 Production technique of glucose injection
CN207917304U (en) * 2017-10-24 2018-09-28 邵阳学院 A kind of packing mechanical equipment

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978637A (en) * 1975-10-24 1976-09-07 Diamond Crystal Salt Company Method and apparatus for making packet assemblies
US4862675A (en) * 1986-02-18 1989-09-05 American National Can Company Packaging method
CN2450093Y (en) * 2000-11-16 2001-09-26 山东龙口凯祥有限公司 Double-layer fruit bag forming machine
JP2006232381A (en) * 2005-02-28 2006-09-07 Dainippon Printing Co Ltd Method and apparatus for sterile packaging
CN200939712Y (en) * 2006-08-15 2007-08-29 山东新华医疗器械股份有限公司 Complete set for producing molyolefine coextruded film powder/liquid dual-chamber soft transfusion bags
CN102642630A (en) * 2012-05-07 2012-08-22 山东新华医疗器械股份有限公司 Full-automatic bag making and filling and sealing machine of bag tail filling non-PVC membrane transfusion soft bag
CN203507132U (en) * 2013-06-03 2014-04-02 湖南科伦制药有限公司 Non-orifice type filling multilayered coextrusion membrane large soft transfusion bag
CN106692047A (en) * 2017-01-16 2017-05-24 浙江都邦药业股份有限公司 Production technique of glucose injection
CN207917304U (en) * 2017-10-24 2018-09-28 邵阳学院 A kind of packing mechanical equipment

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