CN109646646A - A kind of traditional Chinese herbal decoction and preparation method thereof preventing and treating diabetic cardiomyopathy myocardial fibrosis - Google Patents
A kind of traditional Chinese herbal decoction and preparation method thereof preventing and treating diabetic cardiomyopathy myocardial fibrosis Download PDFInfo
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Abstract
The invention belongs to technical field of traditional Chinese medicines, disclose a kind of traditional Chinese herbal decoction and preparation method thereof for preventing and treating diabetic cardiomyopathy myocardial fibrosis.Traditional Chinese herbal decoction is made of Chinese medical extract and water, and the content of Chinese medical extract and water ratio is 15mg~30mg:100mL；Chinese medical extract is prepared from the following raw materials in parts by weight: 10 parts~20 parts of kuh-seng, 10 parts~20 parts of turmeric, 10 parts~20 parts of orange peel, 10 parts~15 parts of silybum marianum seed, 10 parts~20 parts of grape pip, 8 parts~13 parts of Tai Bai Aralia wood, 8 parts~13 parts of Fructus Aurantii, 8 parts~13 parts of ginkgo, 3 parts~5 parts of ginseng, 3 parts~5 parts of leech and 3 parts~5 parts of the coptis.Compared with prior art, beneficial effects of the present invention: the curative effect of the traditional Chinese herbal decoction for treating diabetic cardiomyopathy myocardial fibrosis of the invention is significant and uneasy to recur, without side-effects.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, in particular to a kind of Chinese medicinal decoction for preventing and treating diabetic cardiomyopathy myocardial fibrosis
Agent and preparation method thereof.
Background technique
Diabetic cardiomyopathy (diabetic cardiomyopathy, DCM) is to betide diabetic, cannot use height
Other pathogenic factors such as blood pressure, coronary heart disease are mainly shown as that Ventricular diastolic function is not complete, advanced stage come the cardiomyopathies explained in early days
Then based on systolic dysfunction, Yi Yinfa congestive heart failure.Diabetes myocardial fibrosis
(myocardialfibrosis, MF) occurs mainly in DCM advanced stage, is most common and serious diabetic cardiovascular complications,
Show as the hyper-proliferative of Cardiac Fibroblasts (cardiac fibroblasts, CFs), interstitial collagen largely gathers,
Each Collagen Type VI proportional imbalance etc., Yi Yinqi myocardial stiffness increases, ventricular compliance declines, and then leads to the contraction of ventricle and relax
Insufficiency is opened, heart failure, arrhythmia cordis, cardiogenic shock, or even sudden death are caused.It is tight just because of diabetes MF harm
Again, domestic and foreign scholars study it increasingly deep, and the control efficiency of traditional Chinese medicine is also increasingly affirmed.
Summary of the invention
The object of the present invention is to provide a kind of traditional Chinese herbal decoctions and its preparation for preventing and treating diabetic cardiomyopathy myocardial fibrosis
Method.
To achieve the goals above, the technical solution that the application uses are as follows:
A kind of traditional Chinese herbal decoction preventing and treating diabetic cardiomyopathy myocardial fibrosis, is made of, and described Chinese medical extract and water
The content ratio of Chinese medical extract and the water is 15mg~30mg:100mL；
The Chinese medical extract is prepared from the following raw materials in parts by weight:
10 parts~20 parts of kuh-seng, 10 parts~20 parts of turmeric, 10 parts~20 parts of orange peel, 10 parts of silybum marianum seed~15 parts, grape
10 parts~20 parts of seed, 8 parts~13 parts of Tai Bai Aralia wood, 8 parts~13 parts of Fructus Aurantii, 8 parts~13 parts of ginkgo, 3 parts~5 parts of ginseng, leech 3
Part~5 parts and 3 parts~5 parts of the coptis.
Further, it is made of Chinese medical extract and water, and the content ratio of the Chinese medical extract and the water is 25mg:
100mL；
The Chinese medical extract is prepared from the following raw materials in parts by weight:
15 parts of kuh-seng, 15 parts of turmeric, 15 parts of orange peel, 12 parts of silybum marianum seed, 15 parts of grape pip, 10 parts of Tai Bai Aralia wood, Fructus Aurantii
11 parts, 10 parts of ginkgo, 4 parts of ginseng, 4 parts of leech and 4 parts of the coptis.
In addition, present invention also provides the preparation sides of the traditional Chinese herbal decoction of above-mentioned prevention and treatment diabetic cardiomyopathy myocardial fibrosis
Method includes the following steps:
S1, first, in accordance with needing to weigh bulk pharmaceutical chemicals, be added 10~15 times of weight into bulk pharmaceutical chemicals, and concentration be 75%~
80% ethyl alcohol is stripped operation after impregnating 30min~40min；The temperature of extracting be 60 DEG C~80 DEG C, the time be 4h~
10h, filtering, obtains the first filtrate and filter residue, for use；
S2,8~10 times of weight are added into filter residue obtained in S1, and concentration be 75%~80% and ethyl alcohol, surpass
Sound extracts 2h~3h, and filtering obtains the second filtrate, for use；
S3, the first filtrate is merged with the second filtrate, obtains the first medical fluid, and the first medical fluid is subtracted at 50 DEG C~80 DEG C
Pressure concentration, obtains concentrate；
S4, concentrate is spray-dried, obtains Chinese medical extract；After Chinese medical extract is mixed with water again, obtain
The traditional Chinese herbal decoction for preventing and treating diabetic cardiomyopathy myocardial fibrosis.
Further, the spray drying condition are as follows: inlet air temperature is 95 DEG C~100 DEG C, and leaving air temp is 80 DEG C~90
DEG C, temperature of charge is 60 DEG C~70 DEG C, and atomizing pressure is 0.2Mpa~0.3Mpa, and spray velocity is 10mL/s~12mL/s.
Further, the condition of the ultrasonic extraction in the S2 are as follows: supersonic frequency is 70~120Hz, and temperature is 40~70
℃。
The pharmacological action of each taste bulk pharmaceutical chemicals:
Kuh-seng, return heart, liver, stomach, large intestine, bladder meridian；There are heat-clearing and damp-drying drug, desinsection, the function of diuresis.For hot dysentery, hematochezia is yellow
Subcutaneous ulcer renal shutdown, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, castor control trichomonas vaginitis outside.
Turmeric, returns spleen, Liver Channel；Cure mainly chest and abdomen swelling and pain, shoulder arm numbness pain, it is pained unbearably, postpartum blood pain, ringworm sore is initial, menstruation
It is uncomfortable, amenorrhoea, traumatic injury etc..
Orange peel enters spleen, lung two passes through；Promoting the circulation of qi resolving sputum, invigorating the spleen temperature stomach and other effects.
Silybum marianum seed contains silymarin, can be substantially reduced TGF-β 1, MMP-9, TIMP-1 in diabetes cardiac muscular tissue
And the level of MMP-9/TIMP-1 plays the heart by adjusting the cytokine levels and ECM composition that participate in DCM pathogenesis
Flesh protective effect.
Grape pip, has free radical resisting, and skin, the effect of protection brain etc. are protected in reducing blood lipid.
Too white Aralia wood is specialty in China Midwest Qin_Ba mountain areas and remaining arteries and veins, and main ingredient is triterpenoid saponin.Acrid flavour,
It is bitter；It is mild-natured.Return liver, stomach, kidney channel.Early stage data shows that Tai Bai Aralia wood has hypoglycemic, reducing blood lipid, anti-oxidant and anti-glycosylation
Effect.
Fructus Aurantii is peptic, tonic, carminative and corrigent, is cured cold, indigestion, cough ant phlegm, uterine prolapse,
The diseases such as rectal prolapse.
Ginkgo is mild-natured, bitterness sweet in flavor, slightly poisonous；Enter lung, kidney channel；Cholesterol levels in blood of human body are reduced, artery is prevented
Hardening；Except the deposition ingredient on vascular wall, improve hemorheological property, promote the deformability of red blood cell, reduces blood viscosity,
Keep blood flow unobstructed, cerebral hemorrhage and cerebral infarction can be prevented and treated.
Ginseng, sweet in flavor, slight bitter are warm-natured, flat.Returns spleen, lung channel, the heart channel of Hang-Shaoyin.Tonifying Qi, prevent prolapse are promoted the production of body fluid, and are calmed the nerves, intelligence development.For height
Blood pressure diseases, cardiac muscular dystrophy, coronary sclerosis, angina pectoris etc. have certain therapeutic effect, can mitigate various diseases
Shape.Levis diabetes patient's glucose in urine can be made to reduce, in after isocratic diabetes patient takes ginseng, although it is unobvious to reduce blood glucose effect,
But most overall health of patients make moderate progress, such as thirsty sense symptom disappears or mitigates.
Leech has treatment apoplexy, hypertension, the clear stasis of blood, amenorrhoea, traumatic injury and other effects.
The coptis has the effect of heat-clearing and damp-drying drug, purging fire for removing toxin.For damp and hot feeling of fullness, acid regurgitation, dysentery, jaundice, high fever are vomitted
Coma, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache are quenched one's thirst, carbuncle swells furunculosis；Eczema, wet sore, ear canal stream are controlled outside
Purulence.
Compared with prior art, the present invention is from the root of diabetic cardiomyopathy fibrosis, to the diabetic cardiomyopathy heart
Myofibrosis is treated, the beneficial effects of the present invention are:
Chinese medicine is in the case where compatibility is applied, due to occurring the relationship to interact between drug and drug, so having
A little drugs promote curative effect because of synergistic effect, but also some drugs may but fight mutually and offset, weaken original effect；
Toxicity or side effect has been mitigated or eliminated because of mutual adapted in some drugs, but also some drugs are instead because of interaction
And make declines or the effect of unfavorable human body etc., it is so-called uniline, mutual reinforcement between, mutually makes, mutual restraint between two drugs, the mutual-detoxication, the mutual inhibition, phase
Instead.The compound composition of Chinese medicine is a kind of organizational form for playing Chinese Herbs, it is advantageous in that exquisite monarch, four gas
Five tastes ascending-aescending-floating-sinking reaches the curative effect for improving drug, and weaken the purpose of its adverse side effect by organic cooperation of drug.
For the present invention, using kuh-seng, turmeric, orange peel, silybum marianum seed and grape pip as monarch drug in a prescription, it is intended to inhibit cell Proliferation and glue
Original synthesis increases, and inhibits response to oxidative stress, inhibits CFs proliferation and protection cardiac muscle.Tai Bai Aralia wood, Fructus Aurantii and ginkgo are ministerial drug,
Tai Bai Aralia wood has hypoglycemic, reducing blood lipid, anti-oxidant and resist glycosylated effect；Fructus Aurantii strengthening spleen and nourishing stomach, strengthens physique；Ginkgo protects
Shield heart flesh.Ginseng, leech and the coptis are adjutant, have the effect of qi and activate blood circulation, remove obstruction in channels to relieve pain in conjunction with monarch drug in a prescription and ministerial drug.The present invention
Medicinal material compatibility selected by Chinese materia medica preparation is suitable, meets traditional Chinese medicine and pharmacy and modern medical theory, and yin-yang is balanced, has blood pressure lowering, drop
The effect of blood glucose, protection cardiac muscle, easing pain and diminishing inflammation, replenishing body fluid and clearing away heat pathogen, supplementing qi and nourishing yin, Spleen Bugan kidney, nourishing heart.
Specific embodiment
Technological means of the invention, creation characteristic, achieving the goal is easy to understand with effect in order to make, below in conjunction with
Technical solution of the present invention is clearly and completely described in specific embodiments of the present invention.
Embodiment 1
A kind of traditional Chinese herbal decoction preventing and treating diabetic cardiomyopathy myocardial fibrosis, is made of, and described Chinese medical extract and water
The content ratio of Chinese medical extract and the water is 15mg:100mL；
Chinese medical extract is prepared from the following raw materials in parts by weight:
10 parts of kuh-seng, 10 parts of turmeric, 10 parts of orange peel, 10 parts of silybum marianum seed, 10 parts of grape pip, 8 parts of Tai Bai Aralia wood, Fructus Aurantii 8
Part, 8 parts of ginkgo, 3 parts of ginseng, 3 parts of leech and 3 parts of the coptis.
The preparation method of the traditional Chinese herbal decoction of above-mentioned prevention and treatment diabetic cardiomyopathy myocardial fibrosis, includes the following steps: S1, head
Bulk pharmaceutical chemicals are first weighed as required, and 10 times of weight, and the ethyl alcohol that concentration is 75% are added into bulk pharmaceutical chemicals, after impregnating 30min, into
Row extraction procedure；The temperature of extracting is 60 DEG C, time 10h, and filtering obtains the first filtrate and filter residue, for use；
S2,8 times of weight are added into filter residue obtained in S1, and concentration be 75% and ethyl alcohol, ultrasonic extraction 3h, mistake
Filter, obtains the second filtrate, for use；The condition of ultrasonic extraction are as follows: supersonic frequency 70Hz, temperature are 40 DEG C
S3, the first filtrate is merged with the second filtrate, obtains the first medical fluid, and the first medical fluid is subtracted at 50 DEG C~80 DEG C
Pressure concentration, obtains concentrate；
S4, concentrate is spray-dried, obtains Chinese medical extract；After Chinese medical extract is mixed with water again, obtain
The traditional Chinese herbal decoction for preventing and treating diabetic cardiomyopathy myocardial fibrosis.
Spray drying condition are as follows: inlet air temperature is 95 DEG C, and leaving air temp is 80 DEG C, and temperature of charge is 60 DEG C, atomizing pressure
For 0.2Mpa, spray velocity 10mL/s.
Embodiment 2
A kind of traditional Chinese herbal decoction preventing and treating diabetic cardiomyopathy myocardial fibrosis, is made of, and described Chinese medical extract and water
The content ratio of Chinese medical extract and the water is 25mg:100mL；
The Chinese medical extract is prepared from the following raw materials in parts by weight:
15 parts of kuh-seng, 15 parts of turmeric, 15 parts of orange peel, 12 parts of silybum marianum seed, 15 parts of grape pip, 10 parts of Tai Bai Aralia wood, Fructus Aurantii
11 parts, 10 parts of ginkgo, 4 parts of ginseng, 4 parts of leech and 4 parts of the coptis.
The preparation method of the traditional Chinese herbal decoction of above-mentioned prevention and treatment diabetic cardiomyopathy myocardial fibrosis, includes the following steps: S1, head
Bulk pharmaceutical chemicals are first weighed as required, and 12 times of weight, and the ethyl alcohol that concentration is 78% are added into bulk pharmaceutical chemicals, after impregnating 35min, into
Row extraction procedure；The temperature of extracting is 70 DEG C, time 7h, and filtering obtains the first filtrate and filter residue, for use；
S2,9 times of weight are added into filter residue obtained in S1, and concentration be 78% and ethyl alcohol, ultrasonic extraction 2.5h,
Filtering, obtains the second filtrate, for use；The condition of ultrasonic extraction are as follows: supersonic frequency 100Hz, temperature are 55 DEG C.
S3, the first filtrate is merged with the second filtrate, obtains the first medical fluid, and the first medical fluid depressurized at 70 DEG C dense
Contracting, obtains concentrate；
S4, concentrate is spray-dried, obtains Chinese medical extract；After Chinese medical extract is mixed with water again, obtain
The traditional Chinese herbal decoction for preventing and treating diabetic cardiomyopathy myocardial fibrosis.
Spray drying condition are as follows: inlet air temperature is 98 DEG C, and leaving air temp is 85 DEG C, and temperature of charge is 65 DEG C, atomizing pressure
For 0.25Mpa, spray velocity 11mL/s.
Embodiment 3
A kind of traditional Chinese herbal decoction preventing and treating diabetic cardiomyopathy myocardial fibrosis, is made of, and described Chinese medical extract and water
The content ratio of Chinese medical extract and the water is 30mg:100mL；
Chinese medical extract is prepared from the following raw materials in parts by weight:
20 parts of kuh-seng, 20 parts of turmeric, 20 parts of orange peel, 15 parts of silybum marianum seed, 20 parts of grape pip, 13 parts of Tai Bai Aralia wood, Fructus Aurantii
13 parts, 13 parts of ginkgo, 5 parts of ginseng, 5 parts of leech and 5 parts of the coptis.
The preparation method of the traditional Chinese herbal decoction of above-mentioned prevention and treatment diabetic cardiomyopathy myocardial fibrosis, includes the following steps: S1, head
Bulk pharmaceutical chemicals are first weighed as required, and 15 times of weight, and the ethyl alcohol that concentration is 80% are added into bulk pharmaceutical chemicals, after impregnating 30min, into
Row extraction procedure；The temperature of extracting is 60 DEG C, time 4h, and filtering obtains the first filtrate and filter residue, for use；
S2,10 times of weight are added into filter residue obtained in S1, and concentration be 80% and ethyl alcohol, ultrasonic extraction 2h,
Filtering, obtains the second filtrate, for use；The condition of ultrasonic extraction are as follows: supersonic frequency 120Hz, temperature are 70 DEG C.
S3, the first filtrate is merged with the second filtrate, obtains the first medical fluid, and the first medical fluid depressurized at 80 DEG C dense
Contracting, obtains concentrate；
S4, concentrate is spray-dried, obtains Chinese medical extract；After Chinese medical extract is mixed with water again, obtain
The traditional Chinese herbal decoction for preventing and treating diabetic cardiomyopathy myocardial fibrosis.
Spray drying condition are as follows: inlet air temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure
For 0.3Mpa, spray velocity 12mL/s.
The invention has the advantages that the present invention is using natural Chinese medicine as raw material, using the comprehensive function of each taste medicine from root
Treat diabetic cardiomyopathy myocardial fibrosis in sheet, it is and curative for effect used in pair nontoxic to the human body.
Disclosed above is only presently preferred embodiments of the present invention, and still, the embodiment of the present invention is not limited to this, Ren Heben
What the technical staff in field can think variation should all fall into protection scope of the present invention.
Claims (5)
1. a kind of traditional Chinese herbal decoction for preventing and treating diabetic cardiomyopathy myocardial fibrosis, which is characterized in that by Chinese medical extract and water structure
At, and the content ratio of the Chinese medical extract and the water is 15mg~30mg:100mL；
The Chinese medical extract is prepared from the following raw materials in parts by weight:
10 parts~20 parts of kuh-seng, 10 parts~20 parts of turmeric, 10 parts~20 parts of orange peel, 10 parts~15 parts of silybum marianum seed, grape pip 10
Part~20 parts, 8 parts~13 parts of Tai Bai Aralia wood, 8 parts~13 parts of Fructus Aurantii, 8 parts~13 parts of ginkgo, 3 parts~5 parts of ginseng, 3 parts of leech~
5 parts and 3 parts~5 parts of the coptis.
2. the traditional Chinese herbal decoction of prevention and treatment diabetic cardiomyopathy myocardial fibrosis as described in claim 1, which is characterized in that by Chinese medicine
Extract and water are constituted, and the content ratio of the Chinese medical extract and the water is 25mg:100mL；
The Chinese medical extract is prepared from the following raw materials in parts by weight:
15 parts of kuh-seng, 15 parts of turmeric, 15 parts of orange peel, 12 parts of silybum marianum seed, 15 parts of grape pip, 10 parts of Tai Bai Aralia wood, 11 parts of Fructus Aurantii,
10 parts of ginkgo, 4 parts of ginseng, 4 parts of leech and 4 parts of the coptis.
3. the preparation method of the traditional Chinese herbal decoction of prevention and treatment diabetic cardiomyopathy myocardial fibrosis as claimed in claim 1 or 2, special
Sign is, includes the following steps:
S1, first, in accordance with needing to weigh bulk pharmaceutical chemicals, be added 10~15 times of weight into bulk pharmaceutical chemicals, and volumetric concentration be 75%~
80% ethyl alcohol is stripped operation after impregnating 30min~40min；The temperature of extracting be 60 DEG C~80 DEG C, the time be 4h~
10h, filtering, obtains the first filtrate and filter residue, for use；
S2,8~10 times of weight, and the ethyl alcohol that volumetric concentration is 75%~80%, ultrasound are added into filter residue obtained in S1
2h~3h is extracted, filtering obtains the second filtrate, for use；
S3, the first filtrate is merged with the second filtrate, obtains the first medical fluid, and the first medical fluid depressurized at 50 DEG C~80 DEG C dense
Contracting, obtains concentrate；
S4, concentrate is spray-dried, obtains Chinese medical extract；After Chinese medical extract is mixed with water again, prevented and treated
The traditional Chinese herbal decoction of diabetic cardiomyopathy myocardial fibrosis.
4. the preparation method of the traditional Chinese herbal decoction of prevention and treatment diabetic cardiomyopathy myocardial fibrosis as claimed in claim 3, feature
It is, the spray drying condition are as follows: inlet air temperature is 95 DEG C~100 DEG C, and leaving air temp is 80 DEG C~90 DEG C, and temperature of charge is
60 DEG C~70 DEG C, atomizing pressure is 0.2Mpa~0.3Mpa, and spray velocity is 10mL/s~12mL/s.
5. the preparation method of the traditional Chinese herbal decoction of prevention and treatment diabetic cardiomyopathy myocardial fibrosis as described in claim 1, feature
It is, the condition of the ultrasonic extraction in the S2 are as follows: supersonic frequency is 70~120Hz, and temperature is 40~70 DEG C.
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| WO2006085144A3 (en) * | 2004-10-15 | 2007-01-25 | Photonz Corp Ltd | Compositions containing high omega-3 and low saturated fatty acid levels |
| CN104162035A (en) * | 2014-08-25 | 2014-11-26 | 河南科技大学第一附属医院 | Traditional Chinese medicine composition for treating diabetes and taking method thereof |
| CN108126101A (en) * | 2018-03-05 | 2018-06-08 | 中国人民解放军第四军医大学 | It is a kind of to be used to treat pharmaceutical preparation of diabetic cardiomyopathy and preparation method thereof |
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2019
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006085144A3 (en) * | 2004-10-15 | 2007-01-25 | Photonz Corp Ltd | Compositions containing high omega-3 and low saturated fatty acid levels |
| CN104162035A (en) * | 2014-08-25 | 2014-11-26 | 河南科技大学第一附属医院 | Traditional Chinese medicine composition for treating diabetes and taking method thereof |
| CN108126101A (en) * | 2018-03-05 | 2018-06-08 | 中国人民解放军第四军医大学 | It is a kind of to be used to treat pharmaceutical preparation of diabetic cardiomyopathy and preparation method thereof |
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Application publication date: 20190419 |