CN109645295A - A kind of Astaxanthin In Haematococcus Pluvialis solid beverage maintaining cardiovascular system health - Google Patents

A kind of Astaxanthin In Haematococcus Pluvialis solid beverage maintaining cardiovascular system health Download PDF

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Publication number
CN109645295A
CN109645295A CN201910045542.3A CN201910045542A CN109645295A CN 109645295 A CN109645295 A CN 109645295A CN 201910045542 A CN201910045542 A CN 201910045542A CN 109645295 A CN109645295 A CN 109645295A
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China
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astaxanthin
haematococcus pluvialis
powder
solid beverage
extract
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王维
王维一
杨祖刚
翟运辉
田晓艳
周全勇
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Yunnan Longbre Biotechnology Co Ltd
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Yunnan Longbre Biotechnology Co Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385Concentrates of non-alcoholic beverages
    • A23L2/39Dry compositions
    • A23L2/395Dry compositions in a particular shape or form
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/18Peptides; Protein hydrolysates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/01Hydrolysed proteins; Derivatives thereof
    • A61K38/011Hydrolysed proteins; Derivatives thereof from plants
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention discloses a kind of Astaxanthin In Haematococcus Pluvialis solid beverage for maintaining cardiovascular system health, the raw materials including following mass percentage content: astaxanthin 5~15%, mannan-oligosaccharides 30~35%, wheat oligopeptide 20~30%, Herba Apii graveolentis extract 20~30% and vitamin C 0.5~1%.The present invention is on the basis of traditional astaxanthin food, the resource food for arranging in pairs or groups new, a kind of new beverage food obtained after scientific compatibility, it takes more convenient, this product need to be only melted in wet suit use, it can take for a long time, hypertension can be not only reduced after taking, the probability of apoplexy and heart attack, enhance capillary blood flow and blood antioxidant quality, improve blood vessel endothelium health, it can also assist reducing blood lipid, blood glucose, and ingredient is natural, it has no toxic and side effect to human body, side effect will not be generated as drug, and lower chemical toxicant is remained in vivo.

Description

A kind of Astaxanthin In Haematococcus Pluvialis solid beverage maintaining cardiovascular system health
Technical field
The invention belongs to technical field of food production, and in particular to a kind of haematococcus pluvialis for maintaining cardiovascular system health Astaxanthin solid beverage.
Background technique
Cardiovascular and cerebrovascular disease can be divided into cardiovascular disease and cranial vascular disease.Cardiovascular disease based on coronary heart disease, be by Atherosis occurs in the coronary artery to cardiac muscle supply blood, so that arteries is narrowed or is occluded, deficiency myocardial blood supply causes Can clinically be divided into latent coronary heart disease, angina pectoris, myocardial infarction, myocardial fibrosis and sudden cardiac death.Cerebrovascular disease be On the basis of cerebral arteriovenous malformation, rupture of blood vessel in brain bleeding or thrombosis cause with cerebral haemorrhage or ischemia injury to be main One group of disease of clinical manifestation is commonly called as headstroke, is the principal disease for causing human death at present He disabling.Battalion in blood Feeding substance and oxygen are cell, tissue and organ are required.The direct performance of cardiovascular and cerebrovascular disease is blood flow, especially dynamic Arteries and veins blood flow occurs abnormal.The nitric oxide production adjusting that vascular endothelial cell generates is received in the diastole of blood vessel, and eNOS enzyme activity is Characterize the important indicator of vasodilatory capabilities.It improves blood flow and is especially arterial vascular blood flow, can significantly improve because lacking Cardiovascular and cerebrovascular disease caused by blood.
Haematococcus pluvialis is the highest biology of natural astaxanthin content, and on other occasions, haematococcus pluvialis can accumulate The tired astaxanthin for accounting for its 1% or more dry weight, and astaxanthin structure required for the mechanism of institute's astaxanthin-containing and cultivation object first is that, It is acknowledged as the best biological source of natural astaxanthin.A kind of fat soluble carotenoids, have inoxidizability, it is antitumor and The many important physiology and biological function such as strengthen immunity, inoxidizability are 500~1000 times of vitamin E, for recklessly 10 times of radish element, are the powerful antioxidants generally acknowledged in hydrobiontic alga, can inhibit senile plaque in human body by anti-oxidant It is formed, fatigue tool is inspected to video display terminal operator and is improved significantly, additionally aids what elimination was generated by the time difference Physical discomfort, effect are also more obvious than common epiphysin.So there is astaxanthin important nutritive value and dietotherapy to make With being unanimously generally acknowledged on food products market both at home and abroad at present to have antioxidant activity, antitumor and strengthen immunity etc. many heavy The raw material of the wholefood of the physiology and biological function wanted.
Currently, the product of adjuvant therapy of cardiovascular disease is usually drug and health care product, the raw material that drug uses is chemistry Synthesis or microbial fermentation product, health care product are mostly Chinese medicine using raw material, although there is auxiliary to control for these drugs and health care product The effect of cardiovascular disease is treated, but these drugs or health care product all have some toxic side effects.With astaxanthin exploitation and It utilizes, also occurs the food of a series of capsule based on astaxanthin, tablet in the market, but these contain astaxanthin The generally existing price of food is high, is not easy to eat, and treats the unconspicuous feature of illness effect.Therefore, a kind of formula is developed It is unique, convenient, can be eaten for a long time, have no toxic side effect, can significantly increase antioxidant effect and treatment illness effect it is apparent The Astaxanthin In Haematococcus Pluvialis solid beverage for maintaining cardiovascular system health is desirability.
Summary of the invention
In order to solve the problems, such as background technique, it is unique, edible square that the purpose of the present invention is to provide a kind of formulas Just, it can be eaten for a long time, have no toxic side effect, antioxidant effect can be significantly increased and treatment illness effect significantly remains cardiovascular The Astaxanthin In Haematococcus Pluvialis solid beverage of system health.
The Astaxanthin In Haematococcus Pluvialis solid beverage of the present invention for maintaining cardiovascular system health, including following quality The raw material of degree: astaxanthin 5~15%, mannan-oligosaccharides 30~35%, wheat oligopeptide 20~30%, Herba Apii graveolentis extract 20~30% and vitamin C 0.5~1%.
The Astaxanthin In Haematococcus Pluvialis solid beverage is first by astaxanthin 5~15%, mannan-oligosaccharides 30~35%, wheat Oligopeptide 20~30%, Herba Apii graveolentis extract 20~30% and vitamin C 0.5~1% stir 20~30min in blender, then will Mixture after stirring and evenly mixing is sent into boiling type granulation tower and is granulated, when granulation temperature control at 30~45 DEG C, the time is 20~ 30min, being granulated after obtained particle cools down later can be obtained finished product.
Further, the Astaxanthin In Haematococcus Pluvialis solid beverage also include mass percentage content be 1~3% it is auxiliary Expect the flavoring agent with 0.2~0.5%.
Preferably, the auxiliary material includes the component of following mass parts: 15~20 parts of Kelp Powder, 40~50 parts of ginger powder, garlic 10~20 parts and 5~10 parts of onion powder of powder.
Preferably, the flavoring agent be fructus lycii dry powder, blueberry dry powder, apple dry powder and one of which in lemon dry powder or Two or more mixtures.
Wherein, the wheat oligopeptide is a variety of short-peptide mixtures that wheat bone protein powder is obtained by enzyme degradation.
Preferably, the mannan-oligosaccharides are konjaku Oligomeric manna sugar powder.
Preferably, the preparation method of the astaxanthin is: haematococcus pluvialis first being carried out cryogrinding, later after grinding Haematococcus pluvialis powder in cellulase and pectase be added carry out broken wall, the amount that cellulase is added is haematococcus pluvialis matter The 1~2% of amount, the amount that cellulase is added is the 0.2~0.8% of haematococcus pluvialis quality, and broken wall temperature is 0~4 DEG C, broken wall 1 After~2h, then haematococcus pluvialis powder is dipped in the mixed liquor of ethyl alcohol and ethyl acetate that mass fraction is 75% and carries out ultrasound Wave extracts, and the temperature of ultrasonic wave extraction is 40~50 DEG C, and the power of ultrasonic wave is 300~400W, after 10~20min of ultrasonic extraction Extract is filtered, the filtrate being obtained by filtration carries out vacuum freeze drying again, and the vacuum degree of freeze-drying is 0.5 × 10-1 ~2 × 10-1Mbar, dry temperature are -30~-50 DEG C, and astaxanthin can be obtained after dry 5~10h.
Preferably, the preparation method of the Herba Apii graveolentis extract is: crushing after fresh celery is dried, crosses 80 meshes Obtain celery powder, then by the ethanol water that celery powder and mass fraction are 75% by solid-liquid ratio to be that 1:5~8 mix laggard Row alcohol extracting, 40~60min of alcohol extracting obtain alcohol extract, later again by alcohol extract respectively membrane aperture be 100~120mm, feed liquid temperature Ultrafiltration is carried out under the conditions of degree is 30~40 DEG C, ultrafiltration pressure is 0.1~0.2MPa and obtains filtrate, is finally 8 in pH value by filtrate ~10,40~60min of alkali carries obtains alkali extract under conditions of temperature is 45~55 DEG C, then mass fraction is added in alkali extract and is 30% hydrogen peroxide carries out decolorization and obtains destainer, and the ratio of hydrogen peroxide and alkali extract is 1:2~3, later again by destainer It is filtered, the obtained filtrate of filtering is spray-dried again, can be prepared by Herba Apii graveolentis extract.
Ingredient and the mechanism of action are as follows the effect of each raw material in the present invention:
Astaxanthin is the highest level product of a kind of fat soluble carotenoids and carotenogenesis, is in rediance, Chemical structure is similar to beta carotene.Astaxanthin is one of strongest natural in the world, can effectively clear cell Interior oxygen radical enhances cytothesis ability, maintains organism balance and reduces the accumulation of senile cell, protection is thin from inside to outside Born of the same parents and DNA health promote hair growth to protect skin health, and anti-aging alleviates sports fatigue, invigorates.Both at home and abroad Numerous studies confirm that astaxanthin has stronger antioxidant activity, are improving immunity, pre- preventing tumor, cardiovascular disease, glycosuria The occurrence and development of the chronic diseases such as disease, delay senescence etc. have positive facilitation.
Mannan-oligosaccharides have low-heat, stabilization.The good physicochemical property such as safe and non-toxic, also there is good stomach to adjust Function has both good bifidobacterium growth activity, has effects that protect enteron aisle, improves immunity.
Wheat oligopeptide is the protein extracted from wholefood gluten powder, using orientation digestion and specific small The micromolecule polypeptide substance that peptide isolation technics obtains.The wheat oligopeptide belongs to new resource food, is rich in glutamic acid and paddy The nutritional ingredients such as glutamine, can be improved immunity, can be antifatigue;Especially there is reducing blood lipid, blood pressure lowering is hypoglycemic, antithrombotic, Play the role of that cholesterol is inhibited to rise;Improve diabetic symptom;It can also be used as particular nutrient when intestinal dysfunction simultaneously.
Herba Apii graveolentis extract contains a large amount of cellulose, first is that angiotensins level can be significantly reduced, reduces systolic pressure And diastolic pressure, have effects that reduce blood pressure, second is that can promote enteron aisle that residue is discharged, reduces the absorption of cholesterol.
The beneficial effect comprise that: first is that raw material of the present invention be health ministry approval be both Food is the article of drug again, and nutritive value is abundant, rich in abundant antioxidant content, belongs to natural food;Second is that of the invention It is astaxanthin, mannan-oligosaccharides %, wheat oligopeptide, Herba Apii graveolentis extract and vitamin C through science with the food being made into, both protected Held the supply of raw material nutrition, but allow it is mutual promoted the effect of preventing and curing diseases, can effectively prevent low close in blood The risk that degree albumen is oxidized;Third is that product of the present invention target user's range is wide, ordinary populace and hyperglycemia, hypertension and heart and brain Vascular patients etc. are edible, and Herba Apii graveolentis extract, which is added, can lower cholesterol, and wheat oligopeptide and mannan-oligosaccharides can be Edible crowd provides lecithin, balances the secretion of insulin, can adjust blood glucose and blood pressure;Fourth is that the present invention also uses celery As major ingredient, one side celery belongs to the material of integration of drinking and medicinal herbs, without any side effects, another party more effective to blood pressure lowering Face celery is easy to get, is cheap, is well-known big.
To sum up, the present invention is on the basis of traditional astaxanthin food, the resource food for arranging in pairs or groups new, obtains after scientific compatibility A kind of new beverage food, take it is more convenient, only this product need to be melted in wet suit use, can take for a long time, take The free radical and intracellular free radical between human body cell can be not only eliminated after, protect cells from peroxidization Injury, enables cell normally effectively to carry out metabolism, can prevent plasma low density protein oxidation, while can also show It writes increasing high density lipoprotein and reduces low-density lipoprotein, reduce the formation of plaque deposition, restore blood vessel elasticity, improve blood Flowing enhances capillary blood flow and blood antioxidant matter to reduce hypertension, apoplexy and the probability of heart attack Amount improves blood vessel endothelium health, can also assist reducing blood lipid, blood glucose, and ingredient is natural, have no toxic and side effect to human body, will not As drug generation side effect, and lower chemical toxicant is remained in vivo.It is a kind of food specifically for cardiovascular and cerebrovascular disease research and development, Be formulated it is unique, convenient, can be eaten for a long time, have no toxic side effect, can significantly increase antioxidant effect and treatment illness imitate Fruit clear advantage, use easy to spread.
Specific embodiment
Below with reference to embodiment, the present invention is further illustrated, but the present invention is limited in any way, Based on present invention teach that it is made it is any transform or replace, all belong to the scope of protection of the present invention.
Embodiment 1:
The Astaxanthin In Haematococcus Pluvialis solid beverage of cardiovascular system health, including following quality are maintained described in the present embodiment 1 The raw material of degree: astaxanthin 5%, mannan-oligosaccharides 35%, wheat oligopeptide 30%, Herba Apii graveolentis extract 29.5% and vitamin C 0.5%。
The Astaxanthin In Haematococcus Pluvialis solid beverage is astaxanthin 5%, mannan-oligosaccharides 35%, wheat oligopeptide 30%, celery Dish extract 29.5% and vitamin C 0.5% stir 20min in blender, then the mixture after stirring and evenly mixing is sent into boiling Be granulated in formula granulation tower, when granulation temperature control at 30 DEG C, time 20min, will be granulated later obtained particle it is cooling after i.e. Finished product can be obtained.
Wherein: wheat oligopeptide is a variety of short-peptide mixtures that wheat bone protein powder is obtained by enzyme degradation, can be passed through It is directly commercially available in the market.
The mannan-oligosaccharides are konjaku Oligomeric manna sugar powder, can be directly commercially available by the market.
The preparation method of the astaxanthin is: haematococcus pluvialis first being carried out cryogrinding, rain later after grinding is raw Cellulase is added in haematococcus powder and pectase carries out broken wall, the amount that cellulase is added is haematococcus pluvialis quality 1%, the amount that cellulase is added is the 0.2% of haematococcus pluvialis quality, and broken wall temperature is 0 DEG C, after broken wall 1h, then by the raw red ball of rain Algae powder is dipped in the mixed liquor of ethyl alcohol and ethyl acetate that mass fraction is 75% and carries out ultrasonic wave extraction, ultrasonic wave extraction Temperature is 40 DEG C, and the power of ultrasonic wave is 300W, is filtered extract after ultrasonic extraction 10min, the filtrate being obtained by filtration Vacuum freeze drying is carried out again, and the vacuum degree of freeze-drying is 0.5 × 10-1Mbar, dry temperature are -30 DEG C, after dry 5h Astaxanthin can be obtained.
The preparation method of the Herba Apii graveolentis extract is: crushing after fresh celery is dried, crosses 80 meshes and obtain celery Vegetable powder end, then the ethanol water for being 75% by celery powder and mass fraction by solid-liquid ratio is that alcohol extracting, alcohol are carried out after 1:5 is mixed It mentions 40min and obtains alcohol extract, later again by alcohol extract respectively membrane aperture is 100mm, feed liquid temperature is 30 DEG C, ultrafiltration pressure is Under the conditions of 0.1MPa carry out ultrafiltration obtain filtrate, finally by filtrate under conditions of pH value is 8, temperature is 45 DEG C alkali carries 40min Alkali extract is obtained, then the hydrogen peroxide progress decolorization that mass fraction is 30% is added in alkali extract and obtains destainer, hydrogen peroxide Ratio with alkali extract is 1:2, is later again filtered destainer, the obtained filtrate of filtering is spray-dried again, i.e., Herba Apii graveolentis extract can be made.
Embodiment 2
The Astaxanthin In Haematococcus Pluvialis solid beverage of cardiovascular system health, including following quality are maintained described in the present embodiment 2 The raw material of degree: astaxanthin 10%, mannan-oligosaccharides 33%, wheat oligopeptide 30%, Herba Apii graveolentis extract 25%, vitamin C 0.8%, 1% auxiliary material and 0.2% flavoring agent.
The Astaxanthin In Haematococcus Pluvialis solid beverage is first by astaxanthin 10%, mannan-oligosaccharides 33%, wheat oligopeptide 30%, Herba Apii graveolentis extract 25%, 0.8%, 1% auxiliary material of vitamin C and 0.2% flavoring agent stir 20~30min in blender, Mixture after stirring and evenly mixing again is sent into boiling type granulation tower and is granulated, when granulation temperature control be in 30~45 DEG C, time 20~30min, being granulated after obtained particle cools down later can be obtained finished product
Wherein:
The auxiliary material includes the component of following mass parts: 20 parts of Kelp Powder, 50 parts of ginger powder, 20 parts of garlic powder and 10 parts of onion powder, Traditional kelp mainly directly uses dry kelp, then cutting soaking and water washing is ground using colloid mill to produce dietetic food, The present embodiment is then using making water sublimed after softening, freeze-drying, then grinds and Kelp Powder is made is used, and not only removes fishy smell, changes Good mouthfeel and the laminarin that kelp is rich in is remained, there is better therapeutic effect, ginger powder is taken ginger slice low temperature Vacuum pressed drying and dehydrating is ground into powder again after freezing and the method screened obtains;Garlic powder is powder after being dehydrated garlic It is broken into powder, then saves and obtains under low temperature drying environment;Onion is frequently with juicing heating or General low temperature freeze-drying, vacuum drying Mode, these processing modes can make sulfide decompose or retain it is less, and the present embodiment take it is broken, micro- after cutting, be concentrated very The dry mode of sky, effective component reach maximum reservation.
The flavoring agent be fructus lycii dry powder, blueberry dry powder, apple dry powder and one of which in lemon dry powder or two kinds with On mixture, fructus lycii dry powder, blueberry dry powder, apple dry powder and lemon dry powder have fruity, product can be increased after addition Nutritional ingredient improves the mouthfeel of beverage, adjusts the flavor of beverage, the people that are more suitable reference.
Wheat oligopeptide is a variety of short-peptide mixtures that wheat bone protein powder is obtained by enzyme degradation, can be by the market Directly it is commercially available.
The mannan-oligosaccharides are konjaku Oligomeric manna sugar powder, can be directly commercially available by the market.
The preparation method of the astaxanthin is: haematococcus pluvialis first being carried out cryogrinding, rain later after grinding is raw Cellulase is added in haematococcus powder and pectase carries out broken wall, the amount that cellulase is added is haematococcus pluvialis quality 1.5%, the amount that cellulase is added is the 0.6% of haematococcus pluvialis quality, and broken wall temperature is 2 DEG C, after broken wall 1.5h, then rain is raw Haematococcus powder is dipped in the mixed liquor of ethyl alcohol and ethyl acetate that mass fraction is 75% and carries out ultrasonic wave extraction, and ultrasonic wave mentions The temperature taken is 45 DEG C, and the power of ultrasonic wave is 350W, is filtered extract after ultrasonic extraction 18min, is obtained by filtration Filtrate carries out vacuum freeze drying again, and the vacuum degree of freeze-drying is 0.5 × 10-1Mbar, dry temperature are -40 DEG C, drying 5 Astaxanthin can be obtained after~10h.
The preparation method of the Herba Apii graveolentis extract is: crushing after fresh celery is dried, crosses 80 meshes and obtain celery Vegetable powder end, then the ethanol water for being 75% by celery powder and mass fraction by solid-liquid ratio is that alcohol extracting, alcohol are carried out after 1:7 is mixed It mentions 50min and obtains alcohol extract, later again by alcohol extract respectively membrane aperture is 110mm, feed liquid temperature is 35 DEG C, ultrafiltration pressure is Under the conditions of 0.15MPa carry out ultrafiltration obtain filtrate, finally by filtrate under conditions of pH value is 9, temperature is 50 DEG C alkali carries 40~ 60min obtains alkali extract, then the hydrogen peroxide progress decolorization that mass fraction is 30% is added in alkali extract and obtains destainer, The ratio of hydrogen peroxide and alkali extract is 1:2.5, is later again filtered destainer, the obtained filtrate of filtering is sprayed again It is dry, it can be prepared by Herba Apii graveolentis extract.
Embodiment 3
The Astaxanthin In Haematococcus Pluvialis solid beverage of cardiovascular system health, including following quality are maintained described in the present embodiment 3 The raw material of degree: astaxanthin 15%, mannan-oligosaccharides 35%, wheat oligopeptide 25.5%, Herba Apii graveolentis extract 20% and Wei Sheng Plain 1%, 3% auxiliary material of C and 0.5% flavoring agent.
The Astaxanthin In Haematococcus Pluvialis solid beverage is first by astaxanthin 15%, mannan-oligosaccharides 35%, wheat oligopeptide 25.5%, Herba Apii graveolentis extract 20% and 1%, 3% auxiliary material of vitamin C and 0.5% flavoring agent stir 28min in blender, then Mixture after stirring and evenly mixing is sent into boiling type granulation tower and is granulated, when granulation temperature control at 38 DEG C, time 30min, To be granulated after obtained particle cools down later can be obtained finished product.
Wherein the accessory package includes the component of following mass parts: 15 parts of Kelp Powder, 40 parts of ginger powder, 10 parts of garlic powder and onion 5 parts of powder;Traditional kelp mainly directly uses dry kelp, then cutting soaking and water washing grinds to produce food using colloid mill Product, the present embodiment is then using making water sublimed after softening, freeze-drying, then grinds and Kelp Powder is made is used, and not only removes fishy smell, Improvement mouthfeel and remain the laminarin that kelp is rich in, there is better therapeutic effect, ginger powder be take ginger slice is low Vacuum pressed drying and dehydrating is ground into powder again after temperature freezing and the method screened obtains;Garlic powder is after being dehydrated garlic It is ground into powder, then saves and obtains under low temperature drying environment;Onion does frequently with juicing heating or General low temperature freeze-drying, vacuum Dry mode, these processing modes can make sulfide decompose or retain it is less, and the present embodiment take it is broken, micro- after cutting, being concentrated Vacuum drying mode, effective component reach maximum reservation.
The flavoring agent be fructus lycii dry powder, blueberry dry powder, apple dry powder and one of which in lemon dry powder or two kinds with On mixture, fructus lycii dry powder, blueberry dry powder, apple dry powder and lemon dry powder have fruity, product can be increased after addition Nutritional ingredient improves the mouthfeel of beverage, adjusts the flavor of beverage, the people that are more suitable reference.
Wheat oligopeptide is a variety of short-peptide mixtures that wheat bone protein powder is obtained by enzyme degradation, can be by the market Directly it is commercially available.
The mannan-oligosaccharides are konjaku Oligomeric manna sugar powder, can be directly commercially available by the market.
The preparation method of the astaxanthin is: haematococcus pluvialis first being carried out cryogrinding, rain later after grinding is raw Cellulase is added in haematococcus powder and pectase carries out broken wall, the amount that cellulase is added is the 1 of haematococcus pluvialis quality ~2%, the amount that cellulase is added is the 0.6% of haematococcus pluvialis quality, and broken wall temperature is 3 DEG C, after broken wall 1.5h, then rain is raw Haematococcus powder is dipped in the mixed liquor of ethyl alcohol and ethyl acetate that mass fraction is 75% and carries out ultrasonic wave extraction, and ultrasonic wave mentions The temperature taken is 50 DEG C, and the power of ultrasonic wave is 380W, is filtered extract after ultrasonic extraction 18min, is obtained by filtration Filtrate carries out vacuum freeze drying again, and the vacuum degree of freeze-drying is 0.5 × 10-1Mbar, dry temperature is -45 DEG C, dry Astaxanthin can be obtained after 8h.
The preparation method of the Herba Apii graveolentis extract is: crushing after fresh celery is dried, crosses 80 meshes and obtain celery Vegetable powder end, then the ethanol water for being 75% by celery powder and mass fraction by solid-liquid ratio is that alcohol extracting, alcohol are carried out after 1:7 is mixed It mentions 60min and obtains alcohol extract, later again by alcohol extract respectively membrane aperture is 110mm, feed liquid temperature is 38 DEG C, ultrafiltration pressure is Under the conditions of 0.1 MPa carry out ultrafiltration obtain filtrate, finally by filtrate under conditions of pH value is 9, temperature is 50 DEG C alkali carries 55min Alkali extract is obtained, then the hydrogen peroxide progress decolorization that mass fraction is 30% is added in alkali extract and obtains destainer, hydrogen peroxide Ratio with alkali extract is 1:2.5, is later again filtered destainer, and the obtained filtrate of filtering is spray-dried again, It can be prepared by Herba Apii graveolentis extract.
Embodiment 4
The Astaxanthin In Haematococcus Pluvialis solid beverage of cardiovascular system health, including following quality hundred are maintained described in the present embodiment 4 Divide the raw material than content: astaxanthin 12%, mannan-oligosaccharides 34%, wheat oligopeptide 28%, Herba Apii graveolentis extract 25% and vitamin C 1%。
The Astaxanthin In Haematococcus Pluvialis solid beverage is first by astaxanthin 12%, mannan-oligosaccharides 34%, wheat oligopeptide 28%, Herba Apii graveolentis extract 25% and vitamin C 1% stir 30min in blender, then the mixture after stirring and evenly mixing is sent into boiling Rise in formula granulation tower and be granulated, when granulation temperature control at 45 DEG C, time 30min, will be granulated later obtained particle it is cooling after Finished product can be obtained.
Wherein: the wheat oligopeptide is a variety of short-peptide mixtures that wheat bone protein powder is obtained by enzyme degradation.
The mannan-oligosaccharides are konjaku Oligomeric manna sugar powder.
The preparation method of the astaxanthin is: haematococcus pluvialis first being carried out cryogrinding, rain later after grinding is raw Cellulase is added in haematococcus powder and pectase carries out broken wall, the amount that cellulase is added is haematococcus pluvialis quality 2%, the amount that cellulase is added is the 0.8% of haematococcus pluvialis quality, and broken wall temperature is 4 DEG C, after broken wall 2h, then by the raw red ball of rain Algae powder is dipped in the mixed liquor of ethyl alcohol and ethyl acetate that mass fraction is 75% and carries out ultrasonic wave extraction, ultrasonic wave extraction Temperature is 50 DEG C, and the power of ultrasonic wave is 400W, is filtered extract after ultrasonic extraction 20min, the filtrate being obtained by filtration Vacuum freeze drying is carried out again, and the vacuum degree of freeze-drying is 2 × 10-1Mbar, dry temperature are -50 DEG C, after dry 10h i.e. Astaxanthin can be obtained.
The preparation method of the Herba Apii graveolentis extract is: crushing after fresh celery is dried, crosses 80 meshes and obtain celery Vegetable powder end, then the ethanol water for being 75% by celery powder and mass fraction by solid-liquid ratio is that alcohol extracting, alcohol are carried out after 1:8 is mixed It mentions 60min and obtains alcohol extract, later again by alcohol extract respectively membrane aperture is 120mm, feed liquid temperature is 40 DEG C, ultrafiltration pressure is Under the conditions of 0.2MPa carry out ultrafiltration obtain filtrate, finally by filtrate under conditions of pH value is 10, temperature is 55 DEG C alkali carries 60min Alkali extract is obtained, then the hydrogen peroxide progress decolorization that mass fraction is 30% is added in alkali extract and obtains destainer, hydrogen peroxide Ratio with alkali extract is 1:3, is later again filtered destainer, the obtained filtrate of filtering is spray-dried again, i.e., Herba Apii graveolentis extract can be made.
Main astaxanthin-containing in the present embodiment 1~4, with mannan-oligosaccharides, wheat oligopeptide %, Herba Apii graveolentis extract and vitamin Complementation can not only eliminate free radical and intracellular free radical between human body cell, protect cells from peroxidization Injury, so that cell is normally effectively carried out metabolism, plasma low density protein oxidation can be prevented, while can also Significant increasing high density lipoprotein and reduction low-density lipoprotein, reduce the formation of plaque deposition, restore blood vessel elasticity, improve blood Liquid stream is dynamic, to reduce hypertension, apoplexy and the probability of heart attack, enhances capillary blood flow and blood antioxidant Quality improves blood vessel endothelium health, can also assist reducing blood lipid, blood glucose, and ingredient is natural, has no toxic and side effect to human body, no Side effect can be generated as drug, and remain lower chemical toxicant in vivo, be a kind of food specifically for cardiovascular and cerebrovascular disease research and development Product.
Astaxanthin In Haematococcus Pluvialis of the invention obtains preferable curative effect, takes the satisfaction of rear curative effect up to 90% or more, And see safe without toxic side effect, cost is relatively low, can achieve the purpose that treating both manifestation and root cause of disease, is that a kind of safely and effectively maintenance is cardiovascular The green safe food of system health.According to the formula of above-described embodiment, inventor has carried out 100 people to drink test, 100 people To there is the patient of different degrees of cardiovascular and cerebrovascular disease, after taking a period of time, inventor pays a return visit above-mentioned crowd, In have 95 people think the present invention maintain and treat cardiovascular disease in terms of have good curative effect, obtain the consistent good of patient It comments, satisfaction is up to 95%.Existing special act several test examples therein:
Test example 1: week certain;Male, 44 years old, poor memory, sleep quality was very poor, accidental uncomfortable in chest, palpitation and uneasiness, palpitation and short breath, the heart Rate is uneven;By suggesting, from August 10th, 10 days 1 May in 2018, adhere to taking the rain prepared by embodiment 1 daily Raw haematococcus solid beverage 750mL, after 3 months, foregoing conditions all significantly mitigate, and therapeutic index is 96%.
Test example 2: Lee;Male, 55 years old, after pectoralgia, breastbone or precordialgia, gas was tight, syncope, weak, belch, skin There is color spot;By suggesting, from July 10,10 days to 2018 May in 2018, adheres to taking daily and be made by embodiment 2 Standby haematococcus pluvialis solid beverage 750mL, after two months, after pectoralgia, breastbone or precordialgia, gas is tight, syncope, it is weak, The illnesss such as belch significantly mitigate, and color spot disappearance 90%, therapeutic index is 85%.
Test example 3: Mr. Wang;Female, 30 years old, scalp was often numb, blood supply in brain is insufficient;Through suggestion, from May, 2018 to October by August 10th, 2018, adheres to taking the haematococcus pluvialis solid beverage 750mL prepared by embodiment 3 daily;3 months Afterwards, foregoing conditions all significantly mitigate, and cardiovascular and cerebrovascular disease substantially eliminates, and therapeutic index is 95.2%.
Test example 4: Chen;Female, 40 years old, poor sleeping quality was dizzy, decrease of memory, and eyes are often baffled fuzzy, and gallbladder is solid Alcohol and blood lipid are exceeded, by suggesting, from May, 2018 to October by August 10th, 2018, adhere to taking by embodiment 4 daily The haematococcus pluvialis solid beverage 750mL of preparation;After 3 months, blood lipid and cholesterol value are checked close to normal value, sleep quality obtains To improvement, therapeutic index is 96%.

Claims (9)

1. a kind of Astaxanthin In Haematococcus Pluvialis solid beverage for maintaining cardiovascular system health, it is characterised in that: including following matter Measure the raw material of degree: astaxanthin 5~15%, mannan-oligosaccharides 30~35%, wheat oligopeptide 20~30%, celery extract Object 20~30% and vitamin C 0.5~1%.
2. a kind of Astaxanthin In Haematococcus Pluvialis solid beverage for maintaining cardiovascular system health according to claim 1, Be characterized in that: the Astaxanthin In Haematococcus Pluvialis solid beverage also include mass percentage content be 1~3% auxiliary material and 0.2~ 0.5% flavoring agent.
3. a kind of Astaxanthin In Haematococcus Pluvialis solid beverage for maintaining cardiovascular system health according to claim 2, Be characterized in that: the auxiliary material includes the component of following mass parts: 15~20 parts of Kelp Powder, 40~50 parts of ginger powder, garlic powder 10~ 20 parts and 5~10 parts of onion powder.
4. a kind of Astaxanthin In Haematococcus Pluvialis solid beverage for maintaining cardiovascular system health according to claim 2, Be characterized in that: the flavoring agent be fructus lycii dry powder, blueberry dry powder, apple dry powder and one of which in lemon dry powder or two kinds with On mixture.
5. a kind of Astaxanthin In Haematococcus Pluvialis solid beverage for maintaining cardiovascular system health according to claim 1, Be characterized in that: the wheat oligopeptide is a variety of short-peptide mixtures that wheat bone protein powder is obtained by enzyme degradation.
6. a kind of Astaxanthin In Haematococcus Pluvialis solid beverage for maintaining cardiovascular system health according to claim 1, Be characterized in that: the mannan-oligosaccharides are konjaku Oligomeric manna sugar powder.
7. a kind of Astaxanthin In Haematococcus Pluvialis solid beverage for maintaining cardiovascular system health according to claim 1, Be characterized in that: the preparation method of the astaxanthin is: haematococcus pluvialis first being carried out cryogrinding, rain later after grinding is raw Cellulase is added in haematococcus powder and pectase carries out broken wall, the amount that cellulase is added is the 1 of haematococcus pluvialis quality ~2%, the amount that cellulase is added is the 0.2~0.8% of haematococcus pluvialis quality, and broken wall temperature is 0~4 DEG C, 1~2h of broken wall Afterwards, then haematococcus pluvialis powder progress ultrasonic wave in the mixed liquor of ethyl alcohol and ethyl acetate that mass fraction is 75% is dipped in mention It takes, the temperature of ultrasonic wave extraction is 40~50 DEG C, and the power of ultrasonic wave is 300~400W, will be mentioned after 10~20min of ultrasonic extraction Object is taken to be filtered, the filtrate being obtained by filtration carries out vacuum freeze drying again, and the vacuum degree of freeze-drying is 0.5 × 10-1~2 × 10-1Mbar, dry temperature are -30~-50 DEG C, and astaxanthin can be obtained after dry 5~10h.
8. a kind of Astaxanthin In Haematococcus Pluvialis solid beverage for maintaining cardiovascular system health according to claim 1, Be characterized in that: the preparation method of the Herba Apii graveolentis extract is: crushing after fresh celery is dried, crosses 80 meshes and obtain celery Vegetable powder end, then the ethanol water for being 75% by celery powder and mass fraction by solid-liquid ratio is that alcohol extracting is carried out after 1:5~8 mix, 40~60min of alcohol extracting obtains alcohol extract, later again by alcohol extract respectively membrane aperture be 100~120mm, feed liquid temperature be 30~ 40 DEG C, ultrafiltration pressure be 0.1~0.2MPa under the conditions of carry out ultrafiltration obtain filtrate, finally by filtrate pH value be 8~10, temperature 40~60min of alkali carries obtains alkali extract under conditions of being 45~55 DEG C, then the dioxygen that mass fraction is 30% is added in alkali extract Water carries out decolorization and obtains destainer, and the ratio of hydrogen peroxide and alkali extract is 1:2~3, is later again filtered destainer, The obtained filtrate of filtering is spray-dried again, can be prepared by Herba Apii graveolentis extract.
9. a kind of Astaxanthin In Haematococcus Pluvialis solid beverage for maintaining cardiovascular system health according to claim 1, Be characterized in that: the Astaxanthin In Haematococcus Pluvialis solid beverage is first by astaxanthin 5~15%, mannan-oligosaccharides 30~35%, small Wheat oligopeptide 20~30%, Herba Apii graveolentis extract 20~30% and vitamin C 0.5~1% stir 20~30min in blender, then Mixture after stirring and evenly mixing is sent into boiling type granulation tower and is granulated, and temperature control is at 30~45 DEG C when granulation, the time 20 ~30min, being granulated after obtained particle cools down later can be obtained finished product.
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