CN109645022A - A kind of gardens and hygienic biocide composition containing indoxacarb and effective cypermethrin - Google Patents
A kind of gardens and hygienic biocide composition containing indoxacarb and effective cypermethrin Download PDFInfo
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- CN109645022A CN109645022A CN201910073937.4A CN201910073937A CN109645022A CN 109645022 A CN109645022 A CN 109645022A CN 201910073937 A CN201910073937 A CN 201910073937A CN 109645022 A CN109645022 A CN 109645022A
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- Prior art keywords
- indoxacarb
- composition
- effective
- pulvis
- effective cypermethrin
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Links
- 239000005907 Indoxacarb Substances 0.000 title claims abstract description 61
- VBCVPMMZEGZULK-NRFANRHFSA-N indoxacarb Chemical compound C([C@@]1(OC2)C(=O)OC)C3=CC(Cl)=CC=C3C1=NN2C(=O)N(C(=O)OC)C1=CC=C(OC(F)(F)F)C=C1 VBCVPMMZEGZULK-NRFANRHFSA-N 0.000 title claims abstract description 61
- 239000005946 Cypermethrin Substances 0.000 title claims abstract description 48
- 229960005424 cypermethrin Drugs 0.000 title claims abstract description 48
- KAATUXNTWXVJKI-UHFFFAOYSA-N cypermethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 KAATUXNTWXVJKI-UHFFFAOYSA-N 0.000 title claims abstract description 48
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 4
- 239000003139 biocide Substances 0.000 title claims abstract description 4
- 239000003814 drug Substances 0.000 claims abstract description 47
- 241000238631 Hexapoda Species 0.000 claims description 19
- 241000607479 Yersinia pestis Species 0.000 claims description 15
- 238000009472 formulation Methods 0.000 claims description 14
- 241000736128 Solenopsis invicta Species 0.000 claims description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 9
- 241000257159 Musca domestica Species 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- 241000256602 Isoptera Species 0.000 claims description 6
- 230000002265 prevention Effects 0.000 claims description 6
- 239000002689 soil Substances 0.000 claims description 5
- 206010004194 Bed bug infestation Diseases 0.000 claims description 4
- 241001674044 Blattodea Species 0.000 claims description 4
- 241001327638 Cimex lectularius Species 0.000 claims description 4
- 241000255925 Diptera Species 0.000 claims description 4
- 241001674048 Phthiraptera Species 0.000 claims description 4
- 239000002270 dispersing agent Substances 0.000 claims description 4
- 239000000945 filler Substances 0.000 claims description 4
- 238000009736 wetting Methods 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000005995 Aluminium silicate Substances 0.000 claims description 2
- 235000019738 Limestone Nutrition 0.000 claims description 2
- 235000012211 aluminium silicate Nutrition 0.000 claims description 2
- 239000006229 carbon black Substances 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 238000000227 grinding Methods 0.000 claims description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000006028 limestone Substances 0.000 claims description 2
- 238000003892 spreading Methods 0.000 claims description 2
- 230000007480 spreading Effects 0.000 claims description 2
- 239000000375 suspending agent Substances 0.000 claims description 2
- 239000000454 talc Substances 0.000 claims description 2
- 235000012222 talc Nutrition 0.000 claims description 2
- 229910052623 talc Inorganic materials 0.000 claims description 2
- 239000004562 water dispersible granule Substances 0.000 claims description 2
- 230000002195 synergetic effect Effects 0.000 abstract description 8
- 238000013329 compounding Methods 0.000 abstract description 4
- 206010059866 Drug resistance Diseases 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 230000003993 interaction Effects 0.000 abstract description 2
- 230000010534 mechanism of action Effects 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 22
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 10
- 239000000460 chlorine Substances 0.000 description 10
- 229910052801 chlorine Inorganic materials 0.000 description 10
- 229940079593 drug Drugs 0.000 description 8
- 239000002917 insecticide Substances 0.000 description 7
- 239000012452 mother liquor Substances 0.000 description 5
- 230000005180 public health Effects 0.000 description 5
- 241001509962 Coptotermes formosanus Species 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 239000003905 agrochemical Substances 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 235000013312 flour Nutrition 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000004519 grease Substances 0.000 description 3
- 150000002469 indenes Chemical class 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000003449 preventive effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 231100000820 toxicity test Toxicity 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- 240000008067 Cucumis sativus Species 0.000 description 2
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 240000008415 Lactuca sativa Species 0.000 description 2
- 235000003228 Lactuca sativa Nutrition 0.000 description 2
- 241000866536 Odontotermes formosanus Species 0.000 description 2
- 244000061456 Solanum tuberosum Species 0.000 description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 description 2
- NCSHGROOCJHAFK-UHFFFAOYSA-N [Cl].N#CC#N Chemical compound [Cl].N#CC#N NCSHGROOCJHAFK-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- VEMKTZHHVJILDY-UXHICEINSA-N bioresmethrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OCC1=COC(CC=2C=CC=CC=2)=C1 VEMKTZHHVJILDY-UXHICEINSA-N 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
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- 238000011161 development Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
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- 238000003306 harvesting Methods 0.000 description 2
- 230000000749 insecticidal effect Effects 0.000 description 2
- 231100000225 lethality Toxicity 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- ZOCSXAVNDGMNBV-UHFFFAOYSA-N 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile Chemical compound NC1=C(S(=O)C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl ZOCSXAVNDGMNBV-UHFFFAOYSA-N 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 235000006008 Brassica napus var napus Nutrition 0.000 description 1
- 240000007124 Brassica oleracea Species 0.000 description 1
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 240000008574 Capsicum frutescens Species 0.000 description 1
- 241001674939 Caulanthus Species 0.000 description 1
- 241001414720 Cicadellidae Species 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000005899 Fipronil Substances 0.000 description 1
- 241000219146 Gossypium Species 0.000 description 1
- 241000510199 Helicoverpa assulta Species 0.000 description 1
- 241000255967 Helicoverpa zea Species 0.000 description 1
- 108010034145 Helminth Proteins Proteins 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 241000220225 Malus Species 0.000 description 1
- 235000011430 Malus pumila Nutrition 0.000 description 1
- 235000015103 Malus silvestris Nutrition 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000256259 Noctuidae Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 231100000674 Phytotoxicity Toxicity 0.000 description 1
- 241000255969 Pieris brassicae Species 0.000 description 1
- 241000500437 Plutella xylostella Species 0.000 description 1
- 244000018633 Prunus armeniaca Species 0.000 description 1
- 235000009827 Prunus armeniaca Nutrition 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 241000220324 Pyrus Species 0.000 description 1
- 108010052164 Sodium Channels Proteins 0.000 description 1
- 102000018674 Sodium Channels Human genes 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 235000002597 Solanum melongena Nutrition 0.000 description 1
- 241000256247 Spodoptera exigua Species 0.000 description 1
- 241000985245 Spodoptera litura Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical group [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 241000255901 Tortricidae Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000010410 dusting Methods 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229940013764 fipronil Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 244000000013 helminth Species 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000010452 phosphate Chemical group 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical group [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000002728 pyrethroid Substances 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 150000003871 sulfonates Chemical group 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000011885 synergistic combination Substances 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000004563 wettable powder Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention disclose it is a kind of containing indoxacarb and effective cypermethrin as the gardens hygienic biocide composition of effective component and its application, wherein indoxacarb and effective cypermethrin mixture are apparently higher than raw medicine single dose, and compound synergic effect is obvious.Indoxacarb is different with the mechanism of action of effective cypermethrin, and there is no interaction drug resistances, can fast and effeciently kill resistance larva, slow down resistance；By being used in compounding, control efficiency is good, and dosage is small, extends and kills residual effect, reduces control cost.
Description
Technical field
The present invention relates to the compositions and its application of gardens and public health medication, and in particular to composite reagent synergistic combination
Object.
Background technique
Indoxacarb is a kind of insecticide of DuPont Corporation's development and production.Indoxacarb can effectively prevent grain, cotton, fruit and vegetable
Various pests on equal crops.Suitable for prevention and treatment wild cabbage, flower coconut palm class, cabbage mustard, tomato, capsicum, cucumber, small cucumber, eggplant, lettuce
It is beet armyworm, diamondback moth, cabbage caterpillar, prodenia litura on the crops such as lettuce, apple, pears, peach, apricot, cotton, potato, grape, sweet
Blue noctuid, bollworm, oriental tobacco budworm, leaf rollers, carpocapsa pononella, leafhopper, spark, colorado potato bug.Indoxacarb, which has, tags
And stomach poison function, it is all effective to each instar larvae.Medicament is entered in insect bodies by contact and feeding, and insect is in 0-4 hours
Stop feeding, is benumbed immediately, the coordination ability of insect can decline and (can lead to larva to fall from crop), generally after medicine
It is dead in 24-60 hours.Its insecticidal mechanism is unique, and cross resistance is not present with other insecticides.Indoxacarb is to mammal, family
Poultry low toxicity, while very safe to beneficial insects such as non-target organisms in environment, remains low in crop, and the 2nd day i.e. after medication
It can harvest, especially the crop repeatedly harvested such as greengrocery is well suited for.
Effective cypermethrin is a kind of pyrethroid insecticides, the squama being not only widely used on prevention and treatment crops
Wing mesh pest, the product are non-internal-absorting but have the insecticide tagged with stomach poison function.By interacting with pest sodium channel
And the function of nervous system is destroyed.It is also widely used in public health and animal husbandry and prevents and treats various pests such as fly, cockroach mosquito,
Flea, lice, bedbug, animal vermin such as tick, mite etc..
In the prior art, indoxacarb, effective cypermethrin are widely used in agricultural production in the form of single dose or compounding agent, with
Various agricultural pests are prevented and treated, hygienic medication field is also common, but the compounding of the two processes and there is no report to use.Reasonably
Composite reagent or mixture, which have, to be expanded insecticidal spectrum, improves control efficiency, extend application period, reduce dosage, reduce phytotoxicity, is subtracted
It remains less, the positive feature such as the occurrence and development that delay pest resistance and drug resistance.At present about indoxacarb and efficient chlorine cyanogen
The Pesticidal combination of pyrethroids compounding is for preventing and treating gardens and sanitary insect pest, and there is no literature reported on also without Related product.
Summary of the invention
To solve the deficiencies in the prior art, the present inventor selects indoxacarb and efficient chlorine by a large amount of testing sieve
Cyano chrysanthemate complex composition has apparent synergistic effect in terms of gardens, public health medication.
Thus, it is an object of the invention to propose a kind of indoxacarb and efficient cypermethrin compounded composition, opposite indenes worm
Prestige, effective cypermethrin single dose have apparent synergistic effect, and easy to use, dosage is small, control efficiency is good, control cost
It is low, there is good prospect using upper in prevention and treatment gardens and public health pest field.
Preferably, the indoxacarb and the weight proportion of effective cypermethrin effective component are 0.5~5:5, more preferably 1
~2:5, most preferably 1:5.
Preferably, the dosage form of the composition is pulvis, wettable powder, soluble liquid, aqueous emulsion, suspending agent, water
Dispersible granule, bait formulation, preferably pulvis or bait formulation.
Further, the pulvis preparation method is as follows: weighing former medicine of indoxacarb, effective cypermethrin raw medicine, profit respectively
Pulvis female powder is made in hygroscopic water powder, filler, co-grinding；Take pulvis female powder to be uniformly mixed with fine earth again, that is, when being made use
Indoxacarb effective cypermethrin pulvis (also known as medicine soil), or take the pulvis female powder to mix with diatomite, crush and be made
Indoxacarb effective cypermethrin pulvis when use.Preferably, effective component therein is the indenes worm of 0.2-1.0 weight %
Prestige effective cypermethrin, further preferably the indoxacarb effective cypermethrin of 0.4-0.8 weight %, most preferably 0.6
The indoxacarb effective cypermethrin of weight %.
In one embodiment, the dosage form is bait formulation, is made of flour, carbohydrate, grease and medical fluid mother liquor.
The present invention also provides application of the combinations of the above object in prevention and treatment gardens and sanitary insect pest, which is characterized in that by institute
It states composition sprayed or is dispensed onto purpose place.Wherein the pest is ant, fly, cockroach, mosquito, flea, lice, bedbug, outside animal body
Helminth such as tick, mite.Especially for ant, termite, red fire ant or housefly are become apparent.
In being configured to medicament, wetting dispersing agent appropriate, can for ether nonionic auxiliary agent, esters non-ionic additive,
The collocation of the anionic auxiliaries such as the closed non-ionic additive of terminal hydroxy group and Sulfonates, sulfate, phosphate uses.
Filler appropriate, including clay, kaolin, talcum, diatomite, lime stone, white carbon black etc. are one or more.
In one embodiment, the composition is prepared into bait formulation, wherein solvent appropriate, cosolvent are used, packet
Dimethyl sulfoxide, certain herbaceous plants with big flowers amide are included, dimethyl sulfoxide, propylene glycol etc. are one or more.
Complex composition of the present invention is mainly used for preventing and treating gardens, the pests such as public health, can in outdoor sprinkling or spreading, but
It is that cannot direct plunge into water body use.These pests such as ant, fly, cockroach, mosquito, flea, lice, bedbug, animal vermin is such as
Tick, mite.It is wherein preferably termite, red fire ant or housefly.
Complex composition of the invention compared with prior art, generates following the utility model has the advantages that (1) indoxacarb and efficient chlorine cyanogen
Pyrethroids, which assembles, has science, and compared with single dose, composition is showing apparent synergistic effect, co-toxicity coefficient once compatibility
Reach as high as 227；(2) indoxacarb is different with the mechanism of action of effective cypermethrin, and there is no interaction drug resistances, can be fast and effective
Resistance larva is killed on ground, slows down resistance；(3) the experiment proved that, indoxacarb and efficient cypermethrin compounded use, control efficiency
Good, dosage is small, extends and kills residual effect, reduces control cost.
Specific embodiment
Experimental method and test material used in following embodiments, unless otherwise specified, be conventional method and from
What routine biochemistry reagent shop was commercially available.
The indoor toxicity test of embodiment one, indoxacarb and effective cypermethrin different ratio to termite
By a large amount of Seiving Tests, it is found that indoxacarb and effective cypermethrin mixture have apparent collaboration to ant
Synergistic effect, specific test are as follows:
Test medicine: 90% former medicine of indoxacarb (Jing Bo agrochemical Science and Technology Ltd.)；95% effective cypermethrin raw medicine (river
Su Yang agrochemicals limited liability company).
Medicine soil preparation method: weighing 1.11 grams of 90% former medicine of indoxacarb respectively, 95% 5.26 grams of effective cypermethrin raw medicine,
It 6.00 grams of wetting dispersing agent, 87.63 grams of diatomite, mixes, crushes, pulvis is made；10 grams of the pulvis are taken (to pass through with 90 grams of fine earths
Cross the screening of 20 meshes) it is uniformly mixed, that is, the indoxacarb effective cypermethrin medicine soil that content is 0.6% (weight) is made.(wherein
Former medicine of indoxacarb and effective cypermethrin active ingredients of the original drug total weight are 5.996 grams, then based on 6 grams, the two effective component weight
Amount proportion 1:5.002, then based on 1:5).
The other of indoxacarb effective cypermethrin are matched by effective component, such as 10:1,10:2,10:4,10:8 equal size
Pesticide-clay mixture preparation method and so on.
Subjects: Odontotermes formosanus (Odontotermes formosanus)；Workers of Coptotermes formosanus Shiraki, (Coptotermes
Formosanus), provided by Guangdong Province Insects Research Institute.
Test method: the medicine soil 100g of various concentration is respectively placed in culture dish, the 3 groups of repetitions of each matched proportion density, often
Group is put into test worm 25, and blank control is arranged, and observes test worm death toll afterwards for 24 hours.
Statistical analysis: according to investigation result, the corrected mortality of calculation processing.It is calculated by formula (1) (2), calculated result
Retain 2 significant digits.
P-the death rate, unit are percentage (%)；
K-death borer population, unit are head；
The total borer population of N-processing, unit are head.
P1- corrected mortality, unit are percentage (%)；
Pt- processing the death rate, unit are percentage (%)；
Po- blank the death rate, unit are percentage (%)；
If compareing death rate < 5%, without correction；It compares between the death rate 5% -20%, is corrected by formula (2)；
Death rate > 20% is compareed, test need to reform.
Virulence, which is judged, uses Sun Peiyun method, calculates co-toxicity coefficient (CTC, co-toxicity index)={ actual measurement (A+B)
Theoretical (A+B) the toxicity index TTI of toxicity index ATI/ } 100, measure the index of insecticide mixture whether having a synergistic effect.If
It is synergistic effect that CTC value, which is greater than 120,；It is summation action between 80-120；CTC value is 80 hereinafter, being antagonism
Interpretation of result: indoxacarb and effective cypermethrin different ratio the results are shown in Table 1 to the toxicity test of two kinds of termites, with
And 2 the results are shown in Table to the co-toxicity coefficient of Workers of Coptotermes formosanus Shiraki.
1 indoxacarb of table and effective cypermethrin mixture analyze the measurement result of two kinds of termites
2 indoxacarb of table and effective cypermethrin mixture analyze the measurement result of Workers of Coptotermes formosanus Shiraki
| Dosages distribution (mass ratio) | TTI | ATI | Co-toxicity coefficient |
| Indoxacarb: high chlorine (10:1) | 421 | 470 | 112 |
| Indoxacarb: high chlorine (10:2) | 389 | 440 | 113 |
| Indoxacarb: high chlorine (10:4) | 322 | 391 | 121 |
| Indoxacarb: high chlorine (10:8) | 265 | 326 | 123 |
| Indoxacarb: high chlorine (10:10) | 227 | 304 | 134 |
| Indoxacarb: high chlorine (8:10) | 212 | 326 | 154 |
| Indoxacarb: high chlorine (4:10) | 212 | 391 | 184 |
| Indoxacarb: high chlorine (2:10) | 194 | 440 | 227 |
| Indoxacarb: high chlorine (1:10) | 223 | 470 | 211 |
| Former medicine of indoxacarb | 203 | / | / |
| Effective cypermethrin raw medicine | 40 | / | / |
From table 1 and 2: indoxacarb and the various ratio mixture control efficiency of effective cypermethrin are superior to single dose, wherein
When indoxacarb and effective cypermethrin proportion are 0.5 to 5:5, killing effect synergy is obvious, wherein again with the two proportion for 1 to 2:
The most prominent when 5, the death rate is above 90%, hence it is evident that is higher than raw medicine single dose, compound synergic effect is obvious, and co-toxicity coefficient highest can
Up to 227.Wherein most excellent sexual valence proportion is 1:5.
The pharmacodynamic test of 2 indoxacarb of embodiment and effective cypermethrin to red fire ant
People's Republic of China's agricultural industry criteria (the pesticide indoor biological issued referring to The Ministry of Agriculture of the People's Republic of China, MOA
Measure test rule-insecticide), result is now reported as follows by measurement pharmaceutical agent combinations prevention and treatment red fire ant activity:
1, target is tested
Subjects red fire ant Solenopsis invicta
2, reagent agent
(1) 90% former medicine of indoxacarb of test medicine (Jing Bo agrochemical Science and Technology Ltd.)；95% effective cypermethrin raw medicine
(Yangnong Chemical Co., Ltd., Jiangsu)
(2) comparison medicament
Comparison medicament 1:0.3% fipronil bait is commercially available, friendly domestic hygiene control of insect institute, Guangxi province Liuzhou City ten thousand
Comparison medicament 2:0.1% indoxacarb bait formulation is commercially available, Anhui happiness good harvest agricultural science and technology Co., Ltd
3, test method
3.1 test material
Control damp-warm syndrome light incubator, electronic balance (sensibility reciprocal 0.1mg), stopwatch, glass bar, beaker, filter paper, tweezers, accurate shifting
A set of 100-1000 μ L, 20-100 μ L, 1-20 μ L of liquid rifle etc..
3.2 medicaments are prepared
Bait formulation is prepared according to a conventional method, by indoxacarb, effective cypermethrin raw medicine by the weight ratio of effective component 1:5 with third
Medicament mother liquor is made in ketone dissolution, is configured to effective component 1g/kg, 2g/kg, 4g/kg respectively with flour, carbohydrate, grease and mother liquor,
The bait formulation of 6g/kg, 8g/kg.Wherein by taking 6g/kg bait formulation as an example, preparation method is as follows: weighing 90% former medicine of indoxacarb (capital respectively
Rich agrochemical Science and Technology Ltd.) 1.11g, 95% effective cypermethrin raw medicine (Yangnong Chemical Co., Ltd., Jiangsu) 5.26g,
It is added to 100g dissolution with edible alcohol, had both been made into the mother liquor of 60g/kg.Take mother liquor 10g and 65g flour, 15g edible oil and fat, 10g
Icing Sugar is uniformly mixed, that is, the indoxacarb effective cypermethrin bait formulation that content is 6g/kg is made.Other content preparation methods with
This analogizes.
Wherein, indoxacarb, effective cypermethrin in the bait formulation of effective component 1g/kg, 2g/kg, 4g/kg, 6g/kg, 8g/kg
Content is respectively as follows: 0.17,0.83；0.33,1.67；0.67,3.33；1.00 5.00；1.34 6.66g/kg.
Blank control: the control bait formulation that flour, carbohydrate and grease are configured to.
3.3 test method
The red fire ant of acquisition is placed in transparent, ventilative cloche, and prepared bait formulation is put into cloche.Each place
Reason does 4 repetitions, the death condition of red fire ant after observation for 24 hours.
4, it investigates
The work ant number in cloche is checked after medicine for 24 hours.Normally creeping is ant living, other individuals (cannot creep, face upward turn over or
It is completely dead) belong to dead ant.
5, data statistics and analysis
5.1 calculation
According to survey data, the corrected mortality of each processing is calculated, unit is percentage (%).It is calculated according to the following formula:
Revision insect recluced rate=[(invade insect population before medicine-each day residual individuals after medicine)/invade insect population before medicine] ×
100%；
Correct Revision insect recluced rate=[(treatment region Revision insect recluced rate-check plot Revision insect recluced rate)/(check plot 100- insect population
Decline rate)] × 100%.
5.2 statistical analysis
Regression analysis is carried out to the logarithm of drug dose and the probability value of preventive effect with SPSS software, calculates LC50 and 95%
Confidence limit.
6, result
Chemicals treatment is observed for 24 hours later, and toxicity test result see the table below respectively:
Indoor biometrics result statistical form of 3 different agents of table to red fire ant
Find out from upper table result, test medicine and comparison medicament have certain preventive effect to red fire ant.When test medicine makes
It is 0.6 to 0.8g/kg with concentration, preventive effect is prominent, but comprehensively considers cost performance, then is selected as the dosage of suitable 0.6g/kg, has more
Market application prospect.
3 indoxacarb of embodiment and effective cypermethrin prevent and treat Simulation field test to housefly
Guangdong Province Insects Research Institute is entrusted, indoxacarb and effective cypermethrin is carried out and Simulation field test is prevented and treated to housefly.
1 materials and methods
1.1 test medicines: 0.6% indoxacarb effective cypermethrin pulvis, preparation method are as follows: weighing indenes worm respectively
1.11 grams of prestige raw medicine, 5.26 grams of effective cypermethrin raw medicine, 6.00 grams of wetting dispersing agent, 87.63 grams of diatomite, mixing crushes,
Female powder is made；10 grams of female powder agent and 90 grams of diatomite are taken, mixing crushes to be made and tests required pulvis.
1.2 for trying insect: housefly, 3~4d adult after emergence, half male and half female.
1.3 determination conditions: temperature (26 ± 1) DEG C, relative humidity 78% ± 5%.
1.4 test doses: 2.0g/m is pressed2Dosage dust.
1.5 test procedures:
Hanging cage equipped with 30 test worms is hung over into selected region (10 cage of trial zone, 4 cage of check plot), hanging cage is away from ground
1.0-1.5m about 45 ° upwards of chemical sprayer nozzle, at the uniform velocity dusts to trial zone away from spray 5~8m of point.After application, 1h
When check the test worm number that is hit and borer population living, then regather to cleaning dependent insect cage, restore feeding standard, the examination that do not go down
Worm is not withdrawn, and borer population living is included in.Record death rate when for 24 hours.
2 results: housefly 1h rate of knockdown is 79%, and lethality is 100% for 24 hours.
3 conclusions: 0.6% indoxacarb effective cypermethrin pulvis is used, to the Dusting of housefly, drug effect are as follows: to family
Fly 1h rate of knockdown is 79%, and lethality is 100% for 24 hours, meets " agriculture chemical registration hygienic insecticide pharmacodynamic test and evaluation "
The A grade standard of (GB/T 13917.1-2009).
Claims (10)
1. a kind of gardens and hygienic biocide composition containing indoxacarb and effective cypermethrin as effective component.
2. composition as described in claim 1, which is characterized in that the weight proportion of the indoxacarb and effective cypermethrin is
0.5 ~ 5:5.
3. composition as claimed in claim 2, it is characterised in that: the weight proportion of the indoxacarb and effective cypermethrin is
1 ~ 2:5.
4. composition as described in any one of claims 1 to 3, it is characterised in that: the dosage form of the composition is pulvis, wettable
Property pulvis, soluble liquid, aqueous emulsion, suspending agent, water dispersible granules, bait formulation, preferably pulvis or bait formulation.
5. composition as claimed in claim 4, it is characterised in that: the pulvis preparation method are as follows: weigh indoxacarb original respectively
The female powder of pulvis is made in medicine, effective cypermethrin raw medicine, wetting dispersing agent, filler, co-grinding；Preferably, the filler is viscous
Soil, kaolin, talcum, diatomite, lime stone, white carbon black etc. are one or more.
6. composition as claimed in claim 5, it is characterised in that: mixed with the female powder with fine earth or diatomite, crush into
One step is prepared into pulvis when use, and wherein effective component is the indoxacarb effective cypermethrin of 0.4 ~ 0.8 weight %.
7. composition as claimed in claim 6, it is characterised in that: the effective component is that the indoxacarb of 0.6 weight % is efficient
Cypermethrin.
8. application of the composition as described in any one of claim 1 to 7 in prevention and treatment gardens and sanitary insect pest, feature exist
In by the composition sprayed or spreading purpose place.
9. application as claimed in claim 8, which is characterized in that the pest is ant, fly, cockroach, mosquito, flea, lice, and bedbug moves
Object epizoa such as tick, mite.
10. application as claimed in claim 9, which is characterized in that the pest is termite, red fire ant or housefly.
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| CN108496984A (en) * | 2017-02-28 | 2018-09-07 | 王涛 | A kind of Pesticidal combination containing indoxacarb and effective cypermethrin |
Non-Patent Citations (4)
| Title |
|---|
| 全国农业技术推广服务中心: "《无公害农产品适用农药品种应用指南》", 30 November 2007, 中国农业出版社 * |
| 叶钟音 等: "《现代农药应用技术全书》", 31 October 2002, 中国农业出版社 * |
| 郝智慧等: "《小动物毒理学》", 31 October 2014, 中国农业大学出版社 * |
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