CN109619570A - A kind of infant formula and preparation method thereof of anti-protein allergies - Google Patents
A kind of infant formula and preparation method thereof of anti-protein allergies Download PDFInfo
- Publication number
- CN109619570A CN109619570A CN201910107334.1A CN201910107334A CN109619570A CN 109619570 A CN109619570 A CN 109619570A CN 201910107334 A CN201910107334 A CN 201910107334A CN 109619570 A CN109619570 A CN 109619570A
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- CN
- China
- Prior art keywords
- vitamin
- acid
- powder
- protein
- infant formula
- Prior art date
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- 235000013350 formula milk Nutrition 0.000 title claims abstract description 52
- 206010016946 Food allergy Diseases 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000004365 Protease Substances 0.000 claims abstract description 43
- 108091005804 Peptidases Proteins 0.000 claims abstract description 36
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims abstract description 36
- 102000004407 Lactalbumin Human genes 0.000 claims abstract description 34
- 108090000942 Lactalbumin Proteins 0.000 claims abstract description 34
- 239000000413 hydrolysate Substances 0.000 claims abstract description 25
- 150000001875 compounds Chemical class 0.000 claims abstract description 23
- 238000005119 centrifugation Methods 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 11
- 239000006228 supernatant Substances 0.000 claims abstract description 11
- 102000007544 Whey Proteins Human genes 0.000 claims abstract description 10
- 108010046377 Whey Proteins Proteins 0.000 claims abstract description 10
- 108010009736 Protein Hydrolysates Proteins 0.000 claims abstract description 7
- 230000001376 precipitating effect Effects 0.000 claims abstract description 7
- 235000021119 whey protein Nutrition 0.000 claims abstract description 6
- 239000012460 protein solution Substances 0.000 claims abstract description 5
- 239000000843 powder Substances 0.000 claims description 61
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 57
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 36
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 36
- 235000019419 proteases Nutrition 0.000 claims description 34
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 33
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 24
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 24
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims description 24
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 24
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 22
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 22
- 239000006188 syrup Substances 0.000 claims description 22
- 235000020357 syrup Nutrition 0.000 claims description 22
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 22
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 21
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 21
- 239000008103 glucose Substances 0.000 claims description 21
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 21
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- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 20
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 20
- 239000002253 acid Substances 0.000 claims description 20
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 20
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 19
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 19
- 230000007062 hydrolysis Effects 0.000 claims description 19
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- 235000018102 proteins Nutrition 0.000 claims description 18
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- 108090000623 proteins and genes Proteins 0.000 claims description 18
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
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- 239000000463 material Substances 0.000 claims description 15
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- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 14
- 229940088598 enzyme Drugs 0.000 claims description 14
- 239000004615 ingredient Substances 0.000 claims description 14
- 239000011782 vitamin Substances 0.000 claims description 14
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 13
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 13
- 235000008160 pyridoxine Nutrition 0.000 claims description 13
- 239000011677 pyridoxine Substances 0.000 claims description 13
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 12
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 claims description 12
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 12
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 claims description 12
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- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 12
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims description 12
- 229930010555 Inosine Natural products 0.000 claims description 12
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims description 12
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- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 12
- 235000019482 Palm oil Nutrition 0.000 claims description 12
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- KURVIXMFFSNONZ-WFIJOQBCSA-L disodium;[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound [Na+].[Na+].O[C@@H]1[C@H](O)[C@@H](COP([O-])([O-])=O)O[C@H]1N1C(=O)NC(=O)C=C1 KURVIXMFFSNONZ-WFIJOQBCSA-L 0.000 claims description 12
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Abstract
The present invention relates to a kind of infant formula, especially a kind of infant formula and preparation method thereof of anti-protein allergies.A kind of infant formula of anti-protein allergies, containing lactalbumin hydrolysate, the lactalbumin hydrolysate is prepared using following methods: being added trypsase in hydrolyzed whey protein solution and is digested, goes precipitating to take supernatant hydrolyzate centrifugation；3) compound protease is added in the supernatant that step 2) obtains to digest；Go precipitating that supernatant is taken to be freeze-dried to obtain lactalbumin hydrolysate hydrolyzate centrifugation.Lactalbumin hydrolysate of the invention carries out preliminary exposition to lactalbumin first with trypsase, and allergy epitope is destroyed or degraded using compound protease later, to reduce the anaphylaxis of lactalbumin.The lactalbumin hydrolysate prepared using method of the invention, can not only reduce allergy, and can save nutriment, will not be by excessive decomposition.
Description
Technical field
The present invention relates to a kind of infant formula, the infant formula of especially a kind of anti-protein allergies and its preparation side
Method.
Background technique
Milk protein is usually first part of food proteins of milk formula fed infants intake, and most normal determined food
Anaphylactogen.The main clinical manifestation of milk protein allergy be vomiting, diarrhea, bloody stool, eczema, nerve and infection in respiratory system,
Malabsorption and growth retardation etc..Milk protein allergy refer to that a kind of IgE or non-IgE mediate to milk protein not
Good reaction, baby's incidence is about 2% within 2 years old or less.If cmpa infant cannot get correct diagnosis and treatment, the cmpa of 1/2 or more the moon suffers from
Youngster will develop into more food hypersenstivities, seriously affect the quality of life of infant and its family.So far, strictly avoid milk protein
Intake be treatment the only effective method of cmpa.Therefore for infant and children's early stage correct selection muting sensitive formula substitution
Original formulation improves and the nutrition of cmpa infant and growth and development is promoted to be particularly important.
Summary of the invention
The purpose of the present invention is to provide a kind of infant formulas and preparation method thereof of anti-protein allergies.
The present invention to achieve the above object, using following technical scheme:
1. a kind of infant formula of anti-protein allergies, which is characterized in that containing lactalbumin hydrolysate, the whey
Protolysate is prepared using following methods:
1) 5-8wt% PURE WHEY is soluble in water, citrate buffer solution is added and adjusts pH=4.0；45℃ -50℃
Room temperature centrifugation is down to after keeping 20min in water-bath；
2) sediment obtained 5-8wt% step 1) is soluble in water, is down to after keeping 20min in 85 DEG C of -90 DEG C of water-baths
45 DEG C -50 DEG C, obtain lactoalbumin soln；
3) it adds trypsase into the hydrolyzed whey protein solution that step 2) obtains to be digested, enzyme concentration 5000u/
G, hydrolysis temperature are 50 DEG C, and enzymatic hydrolysis pH is 6.8-7.0, enzymolysis time 1h, by 100 DEG C of enzyme deactivation 15min of hydrolyzate, termination water
Solution；Precipitating is gone to take supernatant hydrolyzate centrifugation；
4) it is 7.5-8.0 that the supernatant for obtaining step 3), which adjusts pH value, and compound protease is added and is digested；, enzymatic hydrolysis
Temperature is 40-60 DEG C, enzymolysis time 2h, by 100 DEG C of enzyme deactivation 15min of hydrolyzate, terminates hydrolysis, and hydrolyzate centrifugation is gone to precipitate
Supernatant is taken to be freeze-dried to obtain lactalbumin hydrolysate.
Compound protease is papain and flavor protease in step 4), and enzyme concentration is papain 2000u/
G, flavor protease 4500u/g.
The trypsase and compound protease is activated using super-pressure；Trypsin activated condition is
Trypsase is dissolved in the buffer that pH is 6.8-7.0, concentration 2mg/ml, in vacuum packaging bag, under 100-150Mpa pressure
Pressure maintaining 15min；The activation condition of compound protease is the buffer that compound protease is proportionally added into pH value and is 7.5-8
In, total concentration 2mg/ml, in vacuum packaging bag, pressure maintaining 15min under 100-150Mpa pressure.
Contain in every 1000kg infant formula: lactalbumin hydrolysate 163-167kg；L-Trp 0.6-0.7kg；
L-tyrosine 0.8-1.0kg；Palm oil 37-40kg；Rapeseed oil 48-50kg；Sunflower oil 40-43kg；Medium chain triglyceride
(MCT)127-130kg；The sweet rouge 10-12kg of citric acid mono-/bis-；First glucose syrup dry powder (DE29) 428-430kg；Taurine
427-430g；L-carnitine 86-88g；Calcium carbonate 708-710g；Magnesium chloride hexahydrate 2900-3000g；Calcium phosphate dibasic anhydrous 5000-
5100g；Sodium Citrate, usp, Dihydrate Powder 390-400g；Potassium hydroxide 876-878g；Citric Acid Mono potassium 1538-1540g；Potassium chloride
3060-3080g；Chlorination gallbladder 1200-1205g；Inositol 175-178g；Sour 25-27g；Pyridoxol (in the form of benadon)
3.3-3.7g；Folic acid 0.8-1.0g；Cyanocobalamin 0.01-0.02g；Biotin 0.1-0.2g；Ascorbic acid is (with sodium ascorbate shape
Formula) 460-463g；Minerals 110.9-115.7g；Calcium carbonate 2490-2500g；Calcium phosphate dibasic anhydrous 1895-1900g；Single phosphorus
Sour cytidine 85-87g；Uridine monophosphate disodium 60-61g；Adenosine monophosphate 52-53g；Sodium guanylate 17-19g；Inosine acid disodium 35-
36g。
The vitamin is vitamin A, vitamine D3, vitamin E, vitamin K1 and vitamin B1 (with thiamine hydrochloride
Form)；The minerals are iodine, selenium, iron, zinc, copper and manganese；Wherein, in every 1000kg infant formula: lactalbumin hydrolysate
163-167kg；L-Trp 0.6-0.7kg；L-tyrosine 0.8-1.0kg；Palm oil 37-40kg；Rapeseed oil 48-50kg；Certain herbaceous plants with big flowers
Flower seed oil 40-43kg；Medium chain triglyceride (MCT) 127-130kg；The sweet rouge 10-12kg of citric acid mono-/bis-；First glucose syrup
Dry powder (DE29) 428-430kg；Taurine 427-430g；L-carnitine 86-88g；Calcium carbonate 708-710g；Magnesium chloride hexahydrate
2900-3000g；Calcium phosphate dibasic anhydrous 5000-5100g；Sodium Citrate, usp, Dihydrate Powder 390-400g；Potassium hydroxide 876-878g；One water
Potassium citrate 1538-1540g；Potassium chloride 3060-3080g；Choline chloride 1200-1205g；Inositol 175-178g；Second grape
Syrup solids (DE29) 100-102kg；Protein free arachidonic acid powder (ARA) 5-7kg；Protein free docosahexaenoic acid
Powder (DHA) 5-5.2kg；Vitamin A 5.5-6.0g；Vitamine D3 0.1-0.2g；Vitamin E 133-137g；Vitamin K1
0.3-0.35g；Vitamin B1 (with thiamine hydrochloride prime form) 4-4.5g；Riboflavin 9-9.5g；Niacin 35-36g；Pantothenic acid 25-
27g；Pyridoxol (in the form of benadon) 3.3-3.7g；Folic acid 0.8-1.0g；Cyanocobalamin 0.01-0.02g；Biotin 0.1-
0.2g；Ascorbic acid (with ascorbic acid na form) 460-463g；Iodine (in the form of potassium iodide) 1-1.2g；Selenium is (with selenous acid
The form of sodium) 0.1-0.2g；Iron (in the form of ferrous sulfate) 64-65g；Zinc (in the form of zinc gluconate) 40-43g；Copper
(in the form of copper sulphate) 3-3.3g；Manganese (in the form of ferric sulfate) 2.8-3.0g；Calcium carbonate 2490-2500g；Anhydrous phosphoric acid hydrogen
Calcium 1895-1900g；Monophosphate cytidine 85-87g；Uridine monophosphate disodium 60-61g；Adenosine monophosphate 52-53g；Sodium guanylate
17-19g；Inosine acid disodium 35-36g.
In every 1000kg infant formula: lactalbumin hydrolysate 165.38kg；L-Trp 0.66kg；L-tyrosine
0.96kg；Palm oil 38.72kg；Rapeseed oil 49.04kg；Sunflower oil 41.30kg；Medium chain triglyceride (MCT) 129.07kg；
The sweet rouge 10.69kg of citric acid mono-/bis-；First glucose syrup dry powder (DE29) 429.75kg；Taurine 428.40g；L-carnitine
86.73g；Calcium carbonate 709.35g；Magnesium chloride hexahydrate 2922.94g；Calcium phosphate dibasic anhydrous 5075.84g；Sodium Citrate, usp, Dihydrate Powder
395.63g；Potassium hydroxide 877.08g；Citric Acid Mono potassium 1538.28g；Potassium chloride 3071.04g；Choline chloride 1201.84g；
Inositol 177.78g；Second glucose syrup dry powder (DE29) 101.51kg；Protein free arachidonic acid powder (ARA) 5.95kg；Nothing
Docosahexaenoic acid powder (DHA) 5.06kg of albumen；Vitamin A 5.70g；Vitamine D3 0.12g；Vitamin E 135g；
Vitamin K1 0.33g；Vitamin B1 (with thiamine hydrochloride prime form) 4.30g；Riboflavin 9.10g；Niacin 35.40g；Pantothenic acid
26.00g；Pyridoxol (in the form of benadon) 3.50g；Folic acid 0.90g；Cyanocobalamin 0.015g；Biotin 0.16g；It is anti-bad
Hematic acid (with ascorbic acid na form) 461.0g；Iodine (in the form of potassium iodide) 1.10g；Selenium (in the form of sodium selenite)
0.16g；Iron (in the form of ferrous sulfate) 64.80g；Zinc (in the form of zinc gluconate) 42.00g；Copper is (with copper sulphate
Form) 3.18g；Manganese (in the form of ferric sulfate) 2.96g；Calcium carbonate 2494.00g；Calcium phosphate dibasic anhydrous 1897.00g；Monophosphate
Cytidine 86.00g；Uridine monophosphate disodium 60.20g；Adenosine monophosphate 52.30g；Sodium guanylate 18.00g；Inosine acid disodium
35.20g。
The present invention also provides the preparation methods of the infant formula of the anti-protein allergies described in one kind, which is characterized in that tool
Preparation step is as follows:
(1) mixing is weighed
Major ingredient: lactalbumin hydrolysate, L-Trp, l-tyrosine, the first glucose syrup dry powder are measured in master by formula
With 50 DEG C of purified water stirring and dissolvings in batch can；
Small powder: taurine, L-carnitine, calcium carbonate, magnesium chloride hexahydrate, calcium phosphate dibasic anhydrous, two water lemons are measured by formula
Lemon acid sodium, potassium hydroxide, Citric Acid Mono potassium, potassium chloride, choline chloride, inositol, vitamin A, vitamine D3, vitamin E, dimension
Raw element K1 is in small batch can with 45 DEG C of purified water stirring and dissolvings；
Oil plant: palm oil, rapeseed oil, sunflower oil, medium chain triglyceride are measured by formula and is stirred in big oil tank with 50 DEG C
Mixing is mixed, from a small amount of miscella is extracted in big oil tank into small oil tank, the sweet ester of citric acid mono-/bis-is added and is dissolved with 85 DEG C；
Ingredient: by dissolved major ingredient, small powder, oil plant, high-speed stirred is mixed 55 DEG C under the conditions of in mixing tank；
(2) configured material homogeneous: is subjected to homogeneous under the conditions of homogenization pressure is 20Mpa；
(3) pasteurize: by the material after homogeneous in disinfection equipment to sterilize 30s at 90 DEG C after, be cooled to 40 immediately
℃；
(4) it is concentrated in vacuo: being evaporated concentration under the conditions of the material after sterilization is warming up to 60 DEG C；
(5) it is spray-dried: the material after concentration is spray-dried, drying condition is 160 DEG C of inlet air temperature, material stream
Speed is 1.25L/h to get original washing powder；
(6) the second glucose syrup dry powder, protein free arachidonic acid powder, protein free 22 carbon six are measured by formula
Olefin(e) acid powder, vitamin B1, riboflavin, niacin, pantothenic acid, pyridoxol, folic acid, cyanocobalamin, biotin, ascorbic acid, iodine, selenium, iron,
Zinc, copper, manganese, monophosphate cytidine, uridine monophosphate disodium, adenosine monophosphate, Sodium guanylate, inosine acid disodium carry out in mixing tank
Dry-mixing, incorporation time 30min is to get finished product.
Compared with prior art, the beneficial effects of the present invention are:
Lactalbumin hydrolysate of the invention carries out preliminary exposition, Zhi Houli to lactalbumin first with trypsase
Allergy epitope is destroyed or degraded with compound protease, to reduce the anaphylaxis of lactalbumin.Using of the invention
The lactalbumin hydrolysate of method preparation, can not only reduce anaphylaxis, and can save nutriment, will not excessively be divided
Solution.Meanwhile activating protease under high pressure, the reaction time of protease can be shortened, the results showed that, reach same
The time of effect, the enzymatic hydrolysis after activation reduces half or more.
The infant formula of anti-protein allergies of the invention is matched by specific prescription and dosage, though in pancreatic lipase and
In the case that cholate level reduces, it also can quickly and effectively absorb, not generate chyle, be suitable for fat digestion, absorption and metabolism
The baby of obstacle (including chylothorax, chyloperitoneum), the infant formula are particularly well suited to the baby of intestinal dysfunction, especially
There is the baby of disturbance of absorptive function.
Detailed description of the invention:
Fig. 1 shows the degree of hydrolysis relational graph of different embodiments and comparative example；
Fig. 2 shows the bitter taste test charts of different embodiments and comparative example；
Fig. 3-4 shows the inhibiting rate figure of the α-LA of different embodiments, β-LG.
Specific embodiment
In order to make those skilled in the art more fully understand technical solution of the present invention, with reference to the accompanying drawing and most
The present invention is described in further detail for good embodiment.
Embodiment 1: lactalbumin hydrolysate is prepared using following methods:
A kind of infant formula of anti-protein allergies, containing lactalbumin hydrolysate, the lactalbumin hydrolysate is adopted
It is prepared with following methods:
1) 6wt% PURE WHEY (whey protein concentrate 80, similarly hereinafter) is soluble in water, citrate buffer solution is added and adjusts
PH=4.0；Room temperature centrifugation is down to after keeping 20min in 50 DEG C of water-baths；
2) sediment obtained 6wt% step 1) is soluble in water, is down to 50 after keeping 20min in 85 DEG C of -90 DEG C of water-baths
DEG C, obtain lactoalbumin soln；
3) it adds trypsase into the hydrolyzed whey protein solution that step 2) obtains to be digested, enzyme concentration 5000u/
G, hydrolysis temperature are 50 DEG C, and enzymatic hydrolysis pH is that 100 DEG C of enzyme deactivation 15min of hydrolyzate are terminated and hydrolyzed by 6.8, enzymolysis time 1h；It will
Hydrolyzate centrifugation goes precipitating to take supernatant；
4) it is 7.5 that the supernatant for obtaining step 3), which adjusts pH value, and compound protease is added and is digested；, hydrolysis temperature
It is 50 DEG C, enzymolysis time 2h, by 100 DEG C of enzyme deactivation 15min of hydrolyzate, terminates hydrolysis, goes precipitating to take supernatant hydrolyzate centrifugation
Liquid is freeze-dried to obtain lactalbumin hydrolysate.Compound protease is papain and flavor protease
(Flavourzyme, similarly hereinafter), enzyme concentration are papain 2000u/g, flavor protease 4500u/g.
The trypsase and compound protease is activated using super-pressure；Trypsin activated condition is
Trypsase is dissolved in the buffer that pH is 7.0, concentration 2mg/ml, in vacuum packaging bag, pressure maintaining under 120Mpa pressure
15min；The activation condition of compound protease is in the buffer that compound protease is proportionally added into pH value and is 8.0, total dense
Spending is 2mg/ml, in vacuum packaging bag, pressure maintaining 15min under 120Mpa pressure.
Comparative example 1: comparative example 1 is identical as 1 ingredient of embodiment and preparation method, and difference is only that not include step 1) acid
The enrichment of α-lactalbumin under the conditions of property.
Comparative example 2: comparative example 2 is identical as 1 ingredient of embodiment and preparation method, and difference is only that lactalbumin wherein, institute
The trypsase and compound protease stated are not used super-pressure and are activated；
Comparative example 3: comparative example 2 is identical as 1 ingredient of embodiment and preparation method, and difference is only that lactalbumin hydrolysate
Preparation method is different: simultaneously into hydrolyzed whey protein solution being added not instead of not stage by stage for protease is added, i.e., simultaneously
Trypsase (5000u/g), flavor protease (4500u/g) and papain (2000u/g) adjusting pH value, which is added, is
100 DEG C of enzyme deactivation 15min of hydrolyzate are terminated hydrolysis by 7.5, enzymolysis time 3h.The trypsase and compound protein
Enzyme is activated using super-pressure；Trypsin activated condition is that trypsase is dissolved in the buffer that pH is 7.0, and concentration is
2mg/ml, in vacuum packaging bag, pressure maintaining 15min under 120Mpa pressure；The activation condition of compound protease is by compound protease
It is proportionally added into the buffer that pH value is 8.0, total concentration 2mg/ml, in vacuum packaging bag, pressure maintaining under 120Mpa pressure
15min。
As a result it tests:
1. measuring its degree of hydrolysis using formol titration, Fig. 1 shows the degree of hydrolysis of embodiment 1 and comparative example 1-3.From figure
1 can be seen that the degree of hydrolysis highest of embodiment 1, and the degree of hydrolysis of comparative example 2 is minimum, analyze the reason is that after high-pressure activated
The activity of protease is higher, and within the same time, degree of hydrolysis is more complete.Comparative example 3 is low compared with embodiment 1, and analysis reason may
It is because different protease is active different in different environments, by different protease as different items in embodiment 1
It is hydrolyzed under part high as the hydrolysis degree hydrolyzed under identical conditions compared to after mixing protease.And comparative example 2 and reality
It applies example 1 to compare, degree of hydrolysis is close but lower, and analysis reason may be with compound protease because of trypsase to the milky white egg of α-
White selectivity is preferable, and the α-lactalbumin contained in lactoalbumin soln after enrichment is more, thus overall degree of hydrolysis it is close but
It is to decrease.
2. bitter taste estimate: weighing 2g Ilex Latifolia Thunb, 500ml distilled water is added to boil 30min, filter, be settled to 500ml.Respectively
20,40,60,80,100 times of dilution, is assessed with 10 silty, and bitter taste score value is the average of evaluation group (10 people).It comments
Minute mark is quasi-: without bitter taste: 2；Slight bitter: 4；It is more bitter: 6；It is bitter: 8；It is very bitter: 10.Fig. 2 shows hydrolyze to produce in different embodiments and comparative example
The bitter taste estimate of object.From its result it is found that bitter taste is positively correlated with degree of hydrolysis.
3. measuring hydrolysate antigen inhibiting rate using indirect competitive ELISA method: the application uses and the patent No.
The identical means of testing of CN201310729169.6 (a kind of subsensitivety glycated milk albumin hydrolysate and preparation method thereof).Figure
The antigenic inhibiting rate of α-LA, β-LG in different embodiments and comparative example is shown respectively in 3-4.Inhibiting rate gets over bottom, and hydrolysate resists
Originality is lower, and the two is proportional.
Embodiment 2: a kind of infant formula of anti-protein allergies, wherein contain in every 1000kg infant formula: implement
Lactalbumin hydrolysate 165.38kg prepared by example 1；L-Trp 0.66kg；L-tyrosine 0.96kg；Palm oil 38.72kg；
Rapeseed oil 49.04kg；Sunflower oil 41.30kg；Medium chain triglyceride (MCT) 129.07kg；The sweet rouge of citric acid mono-/bis-
10.69kg；First glucose syrup dry powder (DE29) 429.75kg；Taurine 428.40g；L-carnitine 86.73g；Calcium carbonate
709.35g；Magnesium chloride hexahydrate 2922.94g；Calcium phosphate dibasic anhydrous 5075.84g；Sodium Citrate, usp, Dihydrate Powder 395.63g；Potassium hydroxide
877.08g；Citric Acid Mono potassium 1538.28g；Potassium chloride 3071.04g；Choline chloride 1201.84g；Inositol 177.78g；Second
Glucose syrup dry powder (DE29) 101.51kg；Protein free arachidonic acid powder (ARA) 5.95kg；Protein free 22 carbon six
Olefin(e) acid powder (DHA) 5.06kg；Vitamin A 5.70g；Vitamine D3 0.12g；Vitamin E 135g；Vitamin K1 0.33g；Dimension
Raw element B1 (with thiamine hydrochloride prime form) 4.30g；Riboflavin 9.10g；Niacin 35.40g；Pantothenic acid 26.00g；Pyridoxol is (with hydrochloric acid
Pyridoxol form) 3.50g；Folic acid 0.90g；Cyanocobalamin 0.015g；Biotin 0.16g；Ascorbic acid is (with sodium ascorbate shape
Formula) 461.0g；Iodine (in the form of potassium iodide) 1.10g；Selenium (in the form of sodium selenite) 0.16g；Iron is (with ferrous sulfate
Form) 64.80g；Zinc (in the form of zinc gluconate) 42.00g；Copper (in the form of copper sulphate) 3.18g；Manganese is (with ferric sulfate
Form) 2.96g；Calcium carbonate 2494.00g；Calcium phosphate dibasic anhydrous 1897.00g；Monophosphate cytidine 86.00g；Uridine monophosphate disodium
60.20g；Adenosine monophosphate 52.30g；Sodium guanylate 18.00g；Inosine acid disodium 35.20g；
A kind of preparation method of the infant formula of anti-protein allergies, specific preparation process is as follows:
(1) mixing is weighed
Major ingredient: lactalbumin hydrolysate, L-Trp, l-tyrosine, the first glucose syrup dry powder are measured by formula
(DE29) with 50 DEG C of purified water stirring and dissolvings in major ingredient tank；
Small powder: taurine, L-carnitine, calcium carbonate, magnesium chloride hexahydrate, calcium phosphate dibasic anhydrous, two water lemons are measured by formula
Lemon acid sodium, potassium hydroxide, Citric Acid Mono potassium, potassium chloride, choline chloride, inositol, vitamin A, vitamine D3, vitamin E, dimension
Raw element K1 is in small batch can with 45 DEG C of purified water stirring and dissolvings；
Oil plant: palm oil, rapeseed oil, sunflower oil, medium chain triglyceride are measured by formula and is stirred in big oil tank with 50 DEG C
Mixing is mixed, from a small amount of miscella is extracted in big oil tank into small oil tank, the sweet ester of citric acid mono-/bis-is added and is dissolved with 85 DEG C；
Ingredient: by dissolved major ingredient, small powder, oil plant, high-speed stirred is mixed 55 DEG C under the conditions of in mixing tank；
(2) configured material homogeneous: is subjected to homogeneous under the conditions of homogenization pressure is 20Mpa；
(3) pasteurize: by the material after homogeneous in disinfection equipment to sterilize 30s at 90 DEG C after, be cooled to 40 immediately
℃；
(4) it is concentrated in vacuo: being evaporated concentration under the conditions of the material after sterilization is warming up to 60 DEG C；
(5) it is spray-dried: the material after concentration is spray-dried, drying condition is 160 DEG C of inlet air temperature, material stream
Speed is 1.25L/h to get original washing powder；
(6) the second glucose syrup dry powder (DE29), protein free arachidonic acid powder, protein free 20 are measured by formula
Two carbon acid powder, vitamin B1, riboflavin, niacin, pantothenic acid, pyridoxol, folic acid, cyanocobalamin, biotin, ascorbic acid, iodine,
Selenium, iron, zinc, copper, manganese, monophosphate cytidine, uridine monophosphate disodium, adenosine monophosphate, Sodium guanylate, inosine acid disodium are in mixing tank
Middle carry out dry-mixing, incorporation time 30min is to get finished product.
Test case:
To the clinical curative effect analysis for the anti-protein allergies formula treated powder babymilk protein allergies that embodiment 1 obtains: surveying
Examination crowd: choosing 50 milk protein allergy infants is research object, the age 1~13 month, infant main clinic symptoms and body
Sign: wherein 30 infants have symptoms of emesis, severe diarrhea, persistent abdominal pain or discomfort (easily crying and screaming), and with a small amount of skin
Eczema；15 have serious skin atopic reaction, and with symptoms such as crissum fash, diarrhea；5 have slight respiratory tract anti-
It infects, wheeze and the symptoms such as allergic rhinitis again, and with laxativeness, abdominal pain, wherein have 11 infants before being admitted to hospital
Drug therapy was carried out, symptom is not delayed.
Infant is after depth hydrolysis' protein prescription milk treated powder 30d, and clinical symptoms and sign have clear improvement, part
Infant allergic symptom completely disappears.Skin eczema infant 15 before treating is reduced after treatment to 2；Respiratory system mistake before treating
Quick infant 5, apnea inflammation infant after treatment；Alimentary canal allergy infant 30 before treating is reduced after treatment to 1.
Wherein, the therapeutic effect of alimentary canal allergic symptom is preferable, and skin eczema and respiratory tract infection therapeutic effect are taken second place.
A kind of embodiment 3: infant formula of anti-protein allergies, wherein every 1000kg；Contain in infant formula: cream
Albumin hydrolysate (preparation of embodiment 1) 167kg；L-Trp 0.7kg；L-tyrosine 0.8kg；Palm oil 37kg；Rapeseed oil
50kg；Sunflower oil 43kg；Medium chain triglyceride (MCT) 127kg；The sweet rouge 12kg of citric acid mono-/bis-；First glucose syrup dry powder
(DE29)428kg；Taurine 427g；L-carnitine 88g；Calcium carbonate 710g；Magnesium chloride hexahydrate 2900g；Calcium phosphate dibasic anhydrous
5000g；Sodium Citrate, usp, Dihydrate Powder 400g；Potassium hydroxide 878g；Citric Acid Mono potassium 1538g；Potassium chloride 3060g；Choline chloride
1205g；Inositol 178g；Second glucose syrup dry powder (DE29) 100kg；Protein free arachidonic acid powder (ARA) 5kg；Without egg
White docosahexaenoic acid powder (DHA) 5.2kg；Vitamin A 6.0g；Vitamine D3 0.1g；Vitamin E 133g；Vitamin
K1 0.35g；Vitamin B1 (with thiamine hydrochloride prime form) 4.5g；Riboflavin 9g；Niacin 36g；Pantothenic acid 25g；Pyridoxol is (with salt
Sour pyridoxol form) 3.7g；Folic acid 0.8g；Cyanocobalamin 0.02g；Biotin 0.2g；Ascorbic acid (with ascorbic acid na form)
460g；Iodine (in the form of potassium iodide) 1g；Selenium (in the form of sodium selenite) 0.2g；Iron (in the form of ferrous sulfate) 64g；Zinc
(in the form of zinc gluconate) 43g；Copper (in the form of copper sulphate) 3.3g；Manganese (in the form of ferric sulfate) 2.8g；Calcium carbonate
2490g；Calcium phosphate dibasic anhydrous 1900g；Monophosphate cytidine 85g；Uridine monophosphate disodium 61g；Adenosine monophosphate 52g；Sodium guanylate
19g；Inosine acid disodium 36g；The preparation method is the same as that of Example 1.
A kind of embodiment 4: infant formula of anti-protein allergies, wherein every 1000kg；Contain in infant formula: cream
Albumin hydrolysate (preparation of embodiment 1) 163kg；L-Trp 0.6kg；L-tyrosine 1.0kg；Palm oil 40kg rapeseed oil
48kg；Sunflower oil 40kg；Medium chain triglyceride (MCT) 130kg；The sweet rouge 10kg of citric acid mono-/bis-；First glucose syrup dry powder
(DE29)430kg；Taurine 430g；L-carnitine 86g；Calcium carbonate 708g；Magnesium chloride hexahydrate 3000g；Calcium phosphate dibasic anhydrous
5100g；Sodium Citrate, usp, Dihydrate Powder 390g；Potassium hydroxide 876g；Citric Acid Mono potassium 1540g；Potassium chloride 3080g；Choline chloride
1200g；Inositol 175g；Second glucose syrup dry powder (DE29) 102kg；Protein free arachidonic acid powder (ARA) 7kg；Without egg
White eicosahexaenoic acid powder (DHA) 5kg；Vitamin A 5.5g；Vitamine D3 0.2g；Vitamin E 137g；Vitamin K1
0.3g；Vitamin B1 (with thiamine hydrochloride prime form) 4g；Riboflavin 9.5g；Niacin 35g；Pantothenic acid 27g；Pyridoxol is (with hydrochloric acid pyrrole
Polyol form) 3.3g；Folic acid 1.0g；Cyanocobalamin 0.01g；Biotin 0.1g；Ascorbic acid (with ascorbic acid na form) 463g；
Iodine (in the form of potassium iodide) 1.2g；Monophosphate cytidine 87g；Uridine monophosphate disodium 60g；Adenosine monophosphate 53g；Sodium guanylate
17g；Inosine acid disodium 35g；
Dosage of each component described in one of embodiment 2-4 is increased or decreased according to same ratio, the parts by weight of gained each component
Number relationship all belongs to the scope of protection of the present invention.
The above is only a preferred embodiment of the present invention, for those of ordinary skill in the art, according to the present invention
Thought, there will be changes in the specific implementation manner and application range, and the content of the present specification should not be construed as to the present invention
Limitation.
Claims (7)
1. a kind of infant formula of anti-protein allergies, which is characterized in that containing lactalbumin hydrolysate, the lactalbumin
Hydrolysate is prepared using following methods:
1) 5-8wt% PURE WHEY is soluble in water, citrate buffer solution is added and adjusts pH=4.0；In 45 DEG C of -50 DEG C of water-baths
Room temperature centrifugation is down to after keeping 20min；
2) sediment obtained 5-8wt% step 1) is soluble in water, in 85 DEG C of -90 DEG C of water-baths keep 20min after be down to 45 DEG C -
50 DEG C, obtain lactoalbumin soln；
3) it adds trypsase into the hydrolyzed whey protein solution that step 2) obtains to be digested, enzyme concentration 5000u/g, enzyme
Solving temperature is 50 DEG C, and enzymatic hydrolysis pH is that 100 DEG C of enzyme deactivation 15min of hydrolyzate are terminated and hydrolyzed by 6.8-7.0, enzymolysis time 1h；It will
Hydrolyzate centrifugation goes precipitating to take supernatant；
4) it is 7.5-8.0 that the supernatant for obtaining step 3), which adjusts pH value, and compound protease is added and is digested；, hydrolysis temperature
It is 40-60 DEG C, 100 DEG C of enzyme deactivation 15min of hydrolyzate are terminated hydrolysis by enzymolysis time 2h, go precipitating to take hydrolyzate centrifugation
Clear liquid is freeze-dried to obtain lactalbumin hydrolysate.
2. the infant formula of anti-protein allergies according to claim 1, which is characterized in that compound protease in step 4)
For papain and flavor protease, enzyme concentration is papain 2000u/g, flavor protease 4500u/g.
3. the infant formula of anti-protein allergies according to claim 2, which is characterized in that the trypsase, with
And compound protease is activated using super-pressure；Trypsin activated condition is that be dissolved in pH be 6.8-7.0's to trypsase
In buffer, concentration 2mg/ml, in vacuum packaging bag, pressure maintaining 15min under 100-150Mpa pressure；The activation of compound protease
Condition is that compound protease is proportionally added into pH value is total concentration 2mg/ml in the buffer of 7.5-8, vacuum packaging bag
In, pressure maintaining 15min under 100-150Mpa pressure.
4. the infant formula of anti-protein allergies according to claim 1, which is characterized in that every 1000kg infant formula
In contain: lactalbumin hydrolysate 163-167kg；L-Trp 0.6-0.7kg；L-tyrosine 0.8-1.0kg；Palm oil 37-
40kg；Rapeseed oil 48-50kg；Sunflower oil 40-43kg；Medium chain triglyceride (MCT) 127-130kg；The sweet rouge of citric acid mono-/bis-
10-12kg；First glucose syrup dry powder (DE29) 428-430kg；Taurine 427-430g；L-carnitine 86-88g；Calcium carbonate
708-710g；Magnesium chloride hexahydrate 2900-3000g；Calcium phosphate dibasic anhydrous 5000-5100g；Sodium Citrate, usp, Dihydrate Powder 390-400g；Hydrogen
Potassium oxide 876-878g；Citric Acid Mono potassium 1538-1540g；Potassium chloride 3060-3080g；Chlorination gallbladder 1200-1205g；Inositol
175-178g；Sour 25-27g；Pyridoxol (in the form of benadon) 3.3-3.7g；Folic acid 0.8-1.0g；Cyanocobalamin 0.01-
0.02g；Biotin 0.1-0.2g；Ascorbic acid (with ascorbic acid na form) 460-463g；Minerals 110.9-115.7g；Carbon
Sour calcium 2490-2500g；Calcium phosphate dibasic anhydrous 1895-1900g；Monophosphate cytidine 85-87g；Uridine monophosphate disodium 60-61g；Single phosphorus
Adenosine monophosphate 52-53g；Sodium guanylate 17-19g；Inosine acid disodium 35-36g.
5. the infant formula of anti-protein allergies according to claim 4, which is characterized in that the vitamin is vitamin
A, vitamine D3, vitamin E, vitamin K1 and vitamin B1 (with thiamine hydrochloride prime form)；The minerals be iodine, selenium, iron,
Zinc, copper and manganese；Wherein, in every 1000kg infant formula: lactalbumin hydrolysate 163-167kg；L-Trp 0.6-
0.7kg；L-tyrosine 0.8-1.0kg；Palm oil 37-40kg；Rapeseed oil 48-50kg；Sunflower oil 40-43kg；Medium chain triglyceride
Three esters (MCT) 127-130kg；The sweet rouge 10-12kg of citric acid mono-/bis-；First glucose syrup dry powder (DE29) 428-430kg；Ox
Sulfonic acid 427-430g；L-carnitine 86-88g；Calcium carbonate 708-710g；Magnesium chloride hexahydrate 2900-3000g；Calcium phosphate dibasic anhydrous
5000-5100g；Sodium Citrate, usp, Dihydrate Powder 390-400g；Potassium hydroxide 876-878g；Citric Acid Mono potassium 1538-1540g；Chlorination
Potassium 3060-3080g；Choline chloride 1200-1205g；Inositol 175-178g；Second glucose syrup dry powder (DE29) 100-102kg；
Protein free arachidonic acid powder (ARA) 5-7kg；Protein free docosahexaenoic acid powder (DHA) 5-5.2kg；Vitamin A
5.5-6.0g；Vitamine D3 0.1-0.2g；Vitamin E 133-137g；Vitamin K1 0.3-0.35g；Vitamin B1 is (with salt
Allithiamine prime form) 4-4.5g；Riboflavin 9-9.5g；Niacin 35-36g；Pantothenic acid 25-27g；Pyridoxol is (with benadon shape
Formula) 3.3-3.7g；Folic acid 0.8-1.0g；Cyanocobalamin 0.01-0.02g；Biotin 0.1-0.2g；Ascorbic acid is (with ascorbic acid
Na form) 460-463g；Iodine (in the form of potassium iodide) 1-1.2g；Selenium (in the form of sodium selenite) 0.1-0.2g；Iron is (with sulphur
Sour ferrous form) 64-65g；Zinc (in the form of zinc gluconate) 40-43g；Copper (in the form of copper sulphate) 3-3.3g；Manganese
(in the form of ferric sulfate) 2.8-3.0g；Calcium carbonate 2490-2500g；Calcium phosphate dibasic anhydrous 1895-1900g；Monophosphate cytidine
85-87g；Uridine monophosphate disodium 60-61g；Adenosine monophosphate 52-53g；Sodium guanylate 17-19g；Inosine acid disodium 35-36g.
6. the infant formula of anti-protein allergies according to claim 4, which is characterized in that every 1000kg infant formula
In: lactalbumin hydrolysate 165.38kg；L-Trp 0.66kg；L-tyrosine 0.96kg；Palm oil 38.72kg；Rapeseed oil
49.04kg；Sunflower oil 41.30kg；Medium chain triglyceride (MCT) 129.07kg；The sweet rouge 10.69kg of citric acid mono-/bis-；First
Glucose syrup dry powder (DE29) 429.75kg；Taurine 428.40g；L-carnitine 86.73g；Calcium carbonate 709.35g；Six water chlorine
Change magnesium 2922.94g；Calcium phosphate dibasic anhydrous 5075.84g；Sodium Citrate, usp, Dihydrate Powder 395.63g；Potassium hydroxide 877.08g；One water lemon
Lemon acid potassium 1538.28g；Potassium chloride 3071.04g；Choline chloride 1201.84g；Inositol 177.78g；Second glucose syrup dry powder
(DE29)101.51kg；Protein free arachidonic acid powder (ARA) 5.95kg；Protein free docosahexaenoic acid powder (DHA)
5.06kg；Vitamin A 5.70g；Vitamine D3 0.12g；Vitamin E 135g；Vitamin K1 0.33g；Vitamin B1 is (with salt
Allithiamine prime form) 4.30g；Riboflavin 9.10g；Niacin 35.40g；Pantothenic acid 26.00g；Pyridoxol (in the form of benadon)
3.50g；Folic acid 0.90g；Cyanocobalamin 0.015g；Biotin 0.16g；Ascorbic acid (with ascorbic acid na form) 461.0g；Iodine
(in the form of potassium iodide) 1.10g；Selenium (in the form of sodium selenite) 0.16g；Iron (in the form of ferrous sulfate) 64.80g；Zinc
(in the form of zinc gluconate) 42.00g；Copper (in the form of copper sulphate) 3.18g；Manganese (in the form of ferric sulfate) 2.96g；Carbon
Sour calcium 2494.00g；Calcium phosphate dibasic anhydrous 1897.00g；Monophosphate cytidine 86.00g；Uridine monophosphate disodium 60.20g；Monophosphate gland
Glycosides 52.30g；Sodium guanylate 18.00g；Inosine acid disodium 35.20g.
7. the preparation method of the infant formula of the described in any item anti-protein allergies of claim 4-6, which is characterized in that specific
Preparation step is as follows:
(1) mixing is weighed
Major ingredient: lactalbumin hydrolysate, L-Trp, l-tyrosine, the first glucose syrup dry powder are measured in major ingredient tank by formula
In with 50 DEG C of purified water stirring and dissolvings；
Small powder: taurine, L-carnitine, calcium carbonate, magnesium chloride hexahydrate, calcium phosphate dibasic anhydrous, citrate dihydrate are measured by formula
Sodium, potassium hydroxide, Citric Acid Mono potassium, potassium chloride, choline chloride, inositol, vitamin A, vitamine D3, vitamin E, vitamin
K1 is in small batch can with 45 DEG C of purified water stirring and dissolvings；
Oil plant: it is mixed with 50 DEG C of stirrings in big oil tank that palm oil, rapeseed oil, sunflower oil, medium chain triglyceride are measured by formula
It closes, from a small amount of miscella is extracted in big oil tank into small oil tank, the sweet ester of citric acid mono-/bis-is added and is dissolved with 85 DEG C；
Ingredient: by dissolved major ingredient, small powder, oil plant, high-speed stirred is mixed 55 DEG C under the conditions of in mixing tank；
(2) configured material homogeneous: is subjected to homogeneous under the conditions of homogenization pressure is 20Mpa；
(3) pasteurize: by the material after homogeneous in disinfection equipment to sterilize 30s at 90 DEG C after, be cooled to 40 DEG C immediately；
(4) it is concentrated in vacuo: being evaporated concentration under the conditions of the material after sterilization is warming up to 60 DEG C；
(5) it is spray-dried: the material after concentration is spray-dried, drying condition is 160 DEG C of inlet air temperature, and material flow is
1.25L/h to get original washing powder；
(6) the second glucose syrup dry powder, protein free arachidonic acid powder, protein free docosahexaenoic acid are measured by formula
Powder, vitamin B1, riboflavin, niacin, pantothenic acid, pyridoxol, folic acid, cyanocobalamin, biotin, ascorbic acid, iodine, selenium, iron, zinc,
Copper, manganese, monophosphate cytidine, uridine monophosphate disodium, adenosine monophosphate, Sodium guanylate, inosine acid disodium are done in mixing tank
Mixing, incorporation time 30min is to get finished product.
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| US11898184B2 (en) | 2017-09-07 | 2024-02-13 | Sweet Sense Inc. | Low glycemic sugar composition |
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