CN109612996B - Chip table positioning device - Google Patents
Chip table positioning device Download PDFInfo
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- CN109612996B CN109612996B CN201811616855.1A CN201811616855A CN109612996B CN 109612996 B CN109612996 B CN 109612996B CN 201811616855 A CN201811616855 A CN 201811616855A CN 109612996 B CN109612996 B CN 109612996B
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- 238000010438 heat treatment Methods 0.000 claims abstract description 8
- 238000007599 discharging Methods 0.000 claims description 6
- 230000007246 mechanism Effects 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 5
- 230000008878 coupling Effects 0.000 claims description 4
- 238000010168 coupling process Methods 0.000 claims description 4
- 238000005859 coupling reaction Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 abstract description 12
- 238000000018 DNA microarray Methods 0.000 abstract description 11
- 230000008569 process Effects 0.000 abstract description 11
- 230000008602 contraction Effects 0.000 abstract description 10
- 238000001514 detection method Methods 0.000 abstract description 6
- 230000009471 action Effects 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 238000005057 refrigeration Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 230000003139 buffering effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001595 contractor effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
Abstract
A chip table positioning device comprises a Y-axis motion plate, a positioning plate, a base, a chip tray, a Z-axis direction positioning unit and an XY plane positioning unit; the Z-axis and XY-plane positioning units drive the chip to move on the Z-axis and XY-plane respectively and share the same power unit. The chip stage positioning device realizes accurate positioning of the biochip in the XYZ direction. Because the upper locating plate is used for locating and is also a chip locating reference surface, in the temperature control process of heating and refrigerating of the refrigerating sheet assembly, the whole refrigerating sheet assembly can sink towards the Z direction under the action of thermal expansion and cold contraction, and the chip detection surface basically keeps unchanged in the Z direction, so that the deformation influence of thermal expansion and cold contraction during temperature control is greatly reduced. The Z-axis direction positioning unit and the XY plane positioning unit share the same power unit, so that the number of parts is reduced, and the manufacturing cost is reduced. The bin inlet and outlet device is adopted, so that the high-precision Y-axis travel is reduced, the device space is further reduced, and the complexity and cost of the system are reduced.
Description
Technical Field
The invention relates to the field of biomedical detection, in particular to a chip table positioning device.
Background
In the field of gene sequencing, a general biochip is placed on a refrigerating sheet component of a chip table in the past, the refrigerating sheet component can heat and refrigerate the biochip to complete biological reaction, an upper cover is arranged on the upper part of the chip table and can rotate around a shaft or translate up and down to position and compress the chip, a fluid component is arranged on the upper cover, a liquid inlet hole and a liquid outlet hole of the fluid component are respectively aligned with a liquid inlet hole and a liquid outlet hole of the biochip, various biological reagents are enabled to flow into the biochip to react, the upper cover is hollow in structure, and an objective lens is fixed on an optical platform in the middle of the upper cover to realize microscopic imaging function. The whole chip table is fixed on a two-dimensional motion platform and can perform XY plane scanning motion.
However, in the above-mentioned chip table, the upper surface of the hot plate of the refrigerating sheet assembly is a reference surface, and the chip is placed on the refrigerating sheet assembly, so that the temperature control process of heating and refrigerating is very easy to generate a height change in the Z direction for the chip due to thermal expansion and cold contraction of the structure, and the objective lens must be required to focus in the Z direction at all times, which is disadvantageous for microscopic imaging.
In addition, in the chip table, the long Y-axis stroke and the avoidance of the objective lens by the opening at the rear end of the upper cover of the chip table are required, so that the chip can be taken and placed by a user, and the structure is complex.
Therefore, the present invention aims to realize accurate positioning of the biochip in XYZ directions. Because the upper locating plate is used for locating and is also a chip locating reference surface, in the temperature control process of heating and refrigerating of the refrigerating sheet assembly, the whole refrigerating sheet assembly can sink towards the Z direction under the action of thermal expansion and cold contraction, at the moment, the chip detection surface basically keeps unchanged in the Z direction, the deformation influence of thermal expansion and cold contraction during temperature control is greatly reduced, the objective lens is not used for focusing in the Z direction, and the time is shortened. And the chip table adopts a bin inlet and outlet device, so that the high-precision Y-axis travel is reduced, the device space is further reduced, and the complexity and cost of the system are reduced.
Disclosure of Invention
The invention aims to provide a chip table positioning device which can realize accurate positioning in the XYZ axis direction in the biochip detection process, and reduces the complexity and cost of a system by adopting a bin inlet and outlet unit.
In order to achieve the above object, the present invention provides a die pad positioning device, comprising: the chip tray comprises a positioning plate 2, a base 3, a chip tray 4, a Z-axis direction positioning unit and an XY plane positioning unit;
the positioning plate 2 is fixedly arranged below the Y-axis moving plate 1, and the Y-axis moving plate 1 is used for positioning the positioning plate 2;
the chip tray 4 is positioned between the positioning plate 2 and the base 3 and is used for placing chips 5;
the Z-axis direction positioning unit drives the chip 5 to move in the Z-axis direction, and the XY plane positioning unit drives the chip 5 to move in the XY plane direction;
the Z-axis direction positioning unit and the XY plane positioning unit share the same power unit.
In some embodiments, the system further comprises a chip in-out bin unit;
when the chip is taken out of the bin, the chip tray 4 extends out of the positioning device and is used for taking and placing the chip 5;
in the case of a warehouse entry, the chip 5 is located below the positioning plate 2.
In some embodiments, the chip access unit comprises:
a frame 11 for accommodating the chip tray 4, wherein a guide groove 6 is arranged on the inner side of the frame 11 along the direction of entering and exiting the bin;
a first motor 10 and a conveying mechanism for conveying the chip tray 4 along the guide slot 6 between an out-bin position and an in-bin position.
In some embodiments, the first motor 10 is fixed on the frame 11 through the motor fixing seat 9; the conveying mechanism comprises a gear 7 and a rack 8, the gear 7 is arranged on an output shaft of a first motor 10, and the rack 8 is arranged on the chip tray 4; the chip tray 4 is provided with a guide rail 41 which is matched with the guide groove 6 to slide; when the first motor 10 rotates, the gear 7 is driven to rotate, and the rack 8 drives the chip tray 4 to move along the guide groove 6.
In some embodiments, the Z-axis direction positioning unit includes:
the refrigerating sheet assembly 12 is fixedly connected to the base 3 through the left slider 20 and the right slider 22, and is used for heating/refrigerating the chip 5, controlling the temperature and supporting the chip 5 to move along the Z-axis direction;
and the slide block guide rails 17 are arranged on two sides of the frame 11 and are used for being matched and connected with the left slide block 20 and the right slide block 22 in a sliding manner.
In some embodiments, the refrigeration unit 12 is provided with a plurality of holes, and the holes are fixedly connected to the base 3 through pins cooperatively disposed on corresponding positions of the left slider 20 and the right slider 22, and elastic elements are disposed on the pins.
In some specific embodiments, the XY plane positioning unit includes:
a plurality of positioning holes 51 provided on the chip 5; a plurality of positioning pins 52 provided on the lower surface of the positioning plate 2 and corresponding to the plurality of positioning holes 51; when the refrigerating sheet assembly 12 supports the chip 5 to move towards the positioning plate 2 along the Z-axis direction, the positioning hole 51 is inserted into the positioning pin 52;
push pins 16 rotatably connected to the base 3, and push pin grooves 161 are provided on the chip 5; when the cooling fin assembly 12 supports the chip 5 to move toward the positioning plate 2 in the Z-axis direction, the push pins 16 push the chip 5 in the push pin grooves 161 so that the positioning holes 51 thereof are aligned toward the positioning pins 52.
In some embodiments, the rotating shaft 18 of the push pin 16 is fixed on the base 3, a round hole is formed in the middle of the push pin 16 and can rotate around the rotating shaft 18, one end of the push pin 16 is a spherical structure 31 and can slide along the guide plate 19, the guide plate 19 is fixed on the frame, the bottom of the other end of the push pin 16 is provided with the tension spring 15 and is connected to the base 3 through the tension spring 15, and the guide plate 19 is of a variable-section curved shape and is fixed on the frame 11.
In some embodiments, the power unit is mounted on a lifting and lowering fixing seat 29, and the lifting and lowering fixing seat 29 is fixedly connected below the frame 11;
the power unit includes:
the second motor 23 is fixedly arranged on the lifting fixing seat 29 through a motor mounting seat 24;
the lifting chute plate 21 is in sliding connection with the base 3, and the base 3 is driven to move in the Z-axis direction by the rotation of the second motor 23.
In some embodiments, the output shaft of the second motor 23 is connected to a screw 28 through a coupling 25; a nut 27 is arranged on the screw rod 28, and the nut 27 is fixedly connected to the lifting chute plate 21; the lifting chute plate 21 is provided with a chute inclined hole 30, and the chute inclined hole 30 is in sliding connection with a cylindrical shaft on the base 3;
when the second motor 23 rotates, the screw rod 28 is driven to axially and linearly move, and the nut 27 drives the lifting chute plate 21 to axially and linearly move, and the lifting chute plate 21 pushes the base 3 to move along the Z-axis direction through the chute inclined hole 30.
In summary, the present invention provides a positioning device for a chip table, which includes a positioning plate 2, a base 3, a chip tray 4, a Z-axis direction positioning unit and an XY-plane positioning unit; the Z-axis direction positioning unit drives the chip 5 to move in the Z-axis direction, and the XY plane positioning unit drives the chip 5 to move on the XY plane; the Z-axis direction positioning unit and the XY plane positioning unit share the same power unit.
The technical scheme of the invention has the following beneficial technical effects:
1. the positioning device adopts a Z-axis direction positioning unit and an XY plane positioning unit to realize the accurate positioning of the biochip in the XYZ direction. Because the upper locating plate is used for locating and is also a chip locating reference surface, in the temperature control process of heating and refrigerating of the refrigerating sheet assembly, the whole refrigerating sheet assembly can sink towards the Z direction under the action of thermal expansion and cold contraction, at the moment, the chip detection surface basically keeps unchanged in the Z direction, the deformation influence of thermal expansion and cold contraction during temperature control is greatly reduced, the objective lens is not used for focusing in the Z direction, and the time is shortened.
2. The Z-axis direction positioning unit and the XY plane positioning unit of the positioning device share the same power unit, so that the number of parts is reduced, and the manufacturing cost is reduced.
3. The chip table adopts the bin inlet and outlet device, reduces the high-precision Y-axis travel, further reduces the device space and reduces the complexity and the cost of the system.
Drawings
FIG. 1 is a schematic view of a positioning device of the present invention in an out-of-position configuration;
FIG. 2 is a schematic view of the positioning device of the present invention in a position of entry;
FIG. 3 is a schematic view of the structure of the Z-axis positioning unit of the present invention;
fig. 4 is a schematic structural view of an XY plane positioning unit of the present invention;
fig. 5 is a schematic view of the power unit of the positioning device of the present invention.
Reference numerals:
1: a Y-axis motion plate; 2: a positioning plate; 3: a base; 4: a tray; 41: a guide rail; 5: a chip; 51: positioning holes; 52: a positioning pin; 6: a guide groove; 7: a gear; 8: a rack; 9: a motor fixing seat; 10: a first motor; 11: a frame; 12: a refrigeration sheet assembly; 121: a positioning block; 14: a spring; 15: a tension spring; 16: pushing pins; 161: a pin pushing groove; 17: a slider guide rail; 18: a rotating shaft; 19: a guide plate; 20: a left slider; 21: lifting the chute plate; 22: a right slider; 23: a second motor; 24: a motor mounting seat; 25: a coupling; 26: a coupling mounting base; 27: a nut; 28: a screw rod; 29: lifting the fixing seat; 30: chute inclined holes; 31: a spherical structure; 32: columnar structure.
Detailed Description
The objects, technical solutions and advantages of the present invention will become more apparent by the following detailed description of the present invention with reference to the accompanying drawings. It should be understood that the description is only illustrative and is not intended to limit the scope of the invention. In addition, in the following description, descriptions of well-known structures and techniques are omitted so as not to unnecessarily obscure the present invention.
The chip table is hung below a Y-axis motion plate of a two-dimensional motion platform. The locating plate of the device is directly fixed with the Y-axis moving plate, the plane of the locating plate, which is in contact with the chip, is a reference plane, and the precision requirement of the chip after clamping can be realized only by ensuring the flatness of the reference plane of the locating plate and the parallelism of the locating plate and the two-dimensional moving shaft.
Detailed description as shown in fig. 1-3, a positioning device for a chip table provided by the present invention includes: the device comprises a Y-axis motion plate 1, a positioning plate 2, a base 3, a chip tray 4, a Z-axis direction positioning unit and an XY plane positioning unit. The positioning plate 2 is fixedly arranged below the Y-axis motion plate 1 and is used for positioning a reference surface of the chip. A chip tray 4 is located between the positioning plate 2 and the base 3 for placing chips 5. The Z-axis direction positioning unit drives the chip (5) to move in the Z-axis direction, and the XY plane positioning unit drives the chip (5) to move in the XY plane direction; the Z-axis direction positioning unit and the XY plane positioning unit share the same power unit.
As shown in fig. 1, the whole structure of the chip table positioning device is hoisted under the two-dimensional motion platform, namely, the positioning plate 2 is hoisted and fixed under the Y-axis motion plate 1. The positioning device base 3 is at the lowest position, and the tray 4 is at the outermost end for a user to take and place the biochip 5.
The positioning device further comprises a chip feeding and discharging unit, the chip feeding and discharging function can be achieved by adopting the positioning device, as shown in fig. 1 and 2, the chip discharging position is shown in fig. 1, and the chip feeding position is shown in fig. 2, so that the function of conveniently taking and placing chips is achieved.
Specifically, as shown in fig. 2, the chip in-out bin unit includes: a frame 11 for accommodating the chip tray 4, wherein a guide groove 6 is arranged on the inner side of the frame 11 along the direction of entering and exiting the bin; a first motor 10 and a conveying mechanism for conveying the chip tray 4 along the guide slot 6 between the out-bin and the in-bin positions. The first motor 10 is fixed on the frame 11 through a motor fixing seat 9; the conveying mechanism comprises a gear 7 and a rack 8, the gear 7 is arranged on an output shaft of the first motor 10, and the rack 8 is arranged on the chip tray 4; the chip tray 4 is provided with a guide rail 41 which slides in cooperation with the guide groove 6. When the first motor 10 rotates, the gear 7 is driven to rotate, the gear 7 drives the rack 8 to move, and the rack 8 drives the chip tray 4 to move along the guide groove 6 through the guide rail 41.
When the chip feeding and discharging unit is adopted, the tray stretches out of the positioning device in the discharging position and is used for taking and placing chips, and the tray is provided with the chip shell contour sinking groove and the guide groove, so that a user can conveniently take and place the chips. The bottom of the tray is provided with a rack or belt structure, so that the tray can move in and out directions. When the chip is in the warehouse-in and warehouse-out unit, the chip is positioned below the positioning plate, the tray is provided with the hollow slotted hole, the refrigerating sheet component 12 moves upwards in the Z-axis direction, and the chip is supported to move through the hollow slotted hole of the tray. The tray power source is a gear motor. The tray has guide rails on both sides and can slide horizontally along the guide slots of the frame.
The chip table positioning device is mainly divided into two parts, namely a Z-axis direction positioning unit for realizing the Z-axis positioning of a chip; and secondly, an XY plane positioning unit realizes the XY direction positioning of the chip through a multipoint positioning and pushing device. The two parts can be linked to realize the positioning function of the chip in the XYZ direction. The Z-axis and XY plane positioning units can be executed by sharing one power device.
Specifically, as shown in fig. 3, the Z-axis direction positioning unit includes: the refrigerating sheet assembly 12 is fixedly connected to the base 3 through the left slider 20 and the right slider 22, and the refrigerating sheet assembly 12 is used for heating/refrigerating the chip 5 to control the temperature of the chip and is used for supporting the chip 5 to move along the Z-axis direction; and a slider guide 17 provided at both sides of the frame 11 for mating sliding connection with the left slider 20 and the right slider 22 such that the left slider 20 and the right slider 22 can move in the Z-axis direction along the slider guide 17.
The refrigerating sheet assembly 12 is provided with a plurality of holes which are fixedly connected to the base 3 through pins which are arranged at corresponding positions of the left slider 20 and the right slider 22 in a matching manner, and elastic elements are arranged on the pins. In a preferred embodiment, the refrigeration cassette assembly 12 is quadrilateral with four corners extending outwardly with a locating block 121, each locating block 121 having an aperture therein; the left slide block 20 and the right slide block 22 are respectively provided with two slide blocks, and each slide block is provided with a pin; the holes on the positioning block 121 are in one-to-one correspondence with pins, so that the refrigerating sheet assembly 12 is connected to the left and right sliding blocks 20 and 22 through the pins and fixed on the base 3.
Further, the pin is provided with an elastic element for separating the left and right sliding blocks from the refrigerating sheet assembly and providing supporting force for the refrigerating sheet assembly. The elastic element can be specifically selected as a spring or a rubber pad, as shown in fig. 3, when the chip 5 is rigidly contacted with the upper positioning plate, the four springs 14 keep pre-pressure, so that the reference surface of the upper positioning plate is contacted with the chip plane to keep constant force, the risk of crushing the chip is also fully avoided, meanwhile, the whole refrigeration piece assembly can sink towards the Z-axis direction due to the effect of thermal expansion and cold contraction in the temperature control process of the refrigeration piece assembly, and the spring or the rubber pad on the column is deformed to play a role of buffering.
By adopting the Z-axis direction positioning unit, the refrigerating sheet assembly drives the chip to move along the Z-axis direction, so that the plane of the chip is completely contacted with the reference surface of the upper positioning plate. The refrigerating sheet component is arranged on the base through the left and right sliding blocks, and the base is laterally provided with a sliding block guide rail which is matched with the left and right sliding blocks so as to realize Z-axis direction movement.
Specifically, as shown in fig. 1 and 4, the XY plane positioning unit includes: a plurality of positioning holes 51 provided on the chip 5; a plurality of positioning pins 52 provided on the lower surface of the positioning plate 2 and corresponding to the plurality of positioning holes 51; when the cooling plate assembly 12 supports the chip 5 to move towards the positioning plate 2 along the Z-axis direction, the positioning hole 51 is inserted into the positioning pin 52; push pins 16 rotatably connected to the base 3, and the chip 5 is provided with push pin grooves 161; when the cooling fin assembly 12 holds up the chip 5 to move toward the positioning plate 2 in the Z-axis direction, the push pins 16 push the chip 5 in the push pin grooves 161 to move in the plane of the XY plane, aligning the positioning holes 51 toward the positioning pins 52.
The specific structure of the push pin 16 is shown in fig. 3, the rotating shaft 18 is fixed on the base 3, a round hole is formed in the middle of the push pin 16 and can rotate around the rotating shaft 18, one end of the push pin 16 is of a spherical structure 31 and can slide along the guide plate 19, the guide plate 19 is fixed on the frame, the bottom of the other end of the push pin 16 is provided with the tension spring 15 and is connected to the base 3 through the tension spring 15, and the guide plate 19 is of a variable-section curved surface shape and is fixed on the frame 11. When the base 3 moves in the Z-axis direction, the columnar structure 32 at the other end of the push pin 16 can push the chip 5 to be aligned with the positioning pin on the XY plane, so that the XY plane positioning function is realized, and the specific implementation mode is shown in the cross-sectional view of the chip and the upper positioning plate in FIG. 4.
As shown in fig. 4, in the process of Z-direction positioning, three-point positioning and pushing the chip 5 upwards, the cooling plate assembly 12 supports the chip 5, and three positioning holes 51 are formed in the casing at two right-angle sides of the chip 5, and three positioning pins 52 of the upper positioning plate 2 gradually pass through the casing, as shown by the dotted line box in the figure. Initially, the positioning holes 51 on the two right-angle sides of the chip 5 do not completely contact the three positioning pins 52 of the upper positioning plate 2, and as the push pins 16 move in the arrow direction shown in fig. 4 due to the linkage structure during the lifting, the push pins 16 push the chip 5 housing during the movement to align the chip 5 with the three positioning pins 52 of the upper positioning plate 2. With the adoption of the structure, the pushing device can realize the positioning function of the chip on the XY plane. The linkage structure simultaneously realizes the functions of positioning the chip in the Z-axis direction and three-point positioning on the XY plane.
The Z-axis direction positioning device and the XY plane positioning device can share a set of power unit. As shown in fig. 5, fig. 5 is a rear view of the chip precise positioning power device. The power unit is mounted on a lifting fixing seat 29, and the lifting fixing seat 29 is fixedly connected below the frame 11. The power unit includes: the second motor 23 is fixedly arranged on the lifting fixing seat 29 through a motor mounting seat 24; the lifting chute plate 21 is in sliding connection with the base 3, and the base 3 is driven to move in the Z-axis direction by the rotation of the second motor 23. An output shaft of the second motor 23 is connected with a screw rod 28 through a coupler 25, and the screw rod 28 is arranged on a lifting fixed seat 29 through a coupler mounting seat 26; the screw rod 28 is provided with a nut 27, and the nut 27 is fixedly connected to the lifting chute plate 21, so that the lifting chute plate 21 moves along the axial direction of the screw rod 28; the lifting chute plate 21 is provided with a chute inclined hole 30, and the chute inclined hole 30 is in sliding connection with a cylindrical shaft on the base 3. When the second motor 23 rotates, the screw rod 28 is driven to rotate, the screw rod rotates to realize axial linear motion of the nut, the nut 27 drives the lifting chute plate 21 to axially linearly move, and the lifting chute plate 21 pushes the base 3 to move along the Z-axis direction through the chute inclined hole 30. The base 3 is fixedly connected with the left slide block 20 and the right slide block 22, the left slide block 20 and the right slide block 22 are respectively connected with the guide rail slide blocks 17 on two sides of the frame, and a sliding slot hole of the lifting sliding groove plate 21 is in sliding connection with a cylindrical shaft of the base 3, so that the Z-shaped upward and downward movement of the base 3 can be pushed when the lifting sliding groove plate 21 moves along the axial direction of the screw rod 28. By adopting the structure, the reinforcement function can be further realized, and enough Z-direction power is provided.
Preferably, the second motor 23 is a gear motor.
The working process of the chip table positioning device provided by the invention is as follows: rotating a first motor, wherein the first motor drives a gear and a rack to move, so that the tray is positioned at a delivery position, and a biochip is placed into a sink on the tray; reversely rotating the first motor to enable the tray to return to the warehouse-in position; the second motor is rotated, the second motor drives the screw rod to rotate through the coupler and drives the nut to do axis linear motion, the nut drives the lifting chute plate to do axis linear motion at the same time, and the lifting chute plate drives the base to move in the Z-axis direction through the sliding of the chute inclined hole and the cylinder shaft; the base supports the refrigerating sheet assembly to move upwards together, so that the chip is rigidly contacted with the upper positioning plate, the spring keeps pre-pressure at the moment, the plane of the chip is contacted with the datum plane of the upper positioning plate to keep constant force, and the risk of crushing the chip is avoided; at the moment, the whole refrigerating sheet assembly sinks downwards towards the Z axis due to the heat expansion and cold contraction effects in the temperature control process, and the spring deformation plays a role in buffering to prevent the refrigerating sheet assembly from sinking, so that the stability of the chip in the Z axis direction is ensured, and the height change cannot be generated from time to time; in the upward movement process of the chip, the pin pushing structure pushes the chip to move in the XY plane, so that the positioning holes on the chip are aligned to the positioning pins on the lower surface of the positioning plate, and finally the positioning pins are inserted into the positioning holes, thereby achieving the accurate positioning of the chip on the XY plane.
In summary, the invention provides a positioning device for a chip table, which comprises a Y-axis motion plate, a positioning plate, a base, a chip tray, a Z-axis direction positioning unit and an XY plane positioning unit; the Z-axis direction positioning unit drives the chip to move in the Z-axis direction, and the XY plane positioning unit drives the chip to move in the XY plane direction; the Z-axis direction positioning unit and the XY plane positioning unit share the same power unit.
The chip table positioning device adopts the Z-axis direction positioning unit and the XY plane positioning unit to realize the accurate positioning of the biochip in the XYZ direction. Because the upper locating plate is used for locating and is also a chip locating reference surface, in the temperature control process of heating and refrigerating of the refrigerating sheet assembly, the whole refrigerating sheet assembly can sink towards the Z direction under the action of thermal expansion and cold contraction, at the moment, the chip detection surface basically keeps unchanged in the Z direction, the deformation influence of thermal expansion and cold contraction during temperature control is greatly reduced, the objective lens is not used for focusing in the Z direction, and the time is shortened. The Z-axis direction positioning unit and the XY plane positioning unit of the positioning device share the same power unit, so that the number of parts is reduced, and the manufacturing cost is reduced. The chip table positioning device adopts the bin inlet and outlet device, reduces the high-precision Y-axis travel, further reduces the space of the device and reduces the complexity and the cost of the system.
It is to be understood that the above-described embodiments of the present invention are merely illustrative of or explanation of the principles of the present invention and are in no way limiting of the invention. Accordingly, any modification, equivalent replacement, improvement, etc. made without departing from the spirit and scope of the present invention should be included in the scope of the present invention. Furthermore, the appended claims are intended to cover all such changes and modifications that fall within the scope and boundary of the appended claims, or equivalents of such scope and boundary.
Claims (8)
1. A die pad positioning device, comprising: the chip tray comprises a positioning plate (2), a base (3), a chip tray (4), a Z-axis direction positioning unit and an XY plane positioning unit;
the positioning plate (2) is fixedly arranged below the Y-axis moving plate (1), and the Y-axis moving plate (1) is used for positioning the positioning plate (2);
the chip tray (4) is positioned between the positioning plate (2) and the base (3) and is used for placing chips (5);
the Z-axis direction positioning unit drives the chip (5) to move in the Z-axis direction, and the XY plane positioning unit drives the chip (5) to move in the XY plane direction;
the Z-axis direction positioning unit and the XY plane positioning unit share the same power unit;
the Z-axis direction positioning unit includes:
the refrigerating sheet assembly (12) is fixedly connected to the base (3) through the left sliding block (20) and the right sliding block (22), is used for heating/refrigerating the chip (5), controlling the temperature and is used for supporting the chip (5) to move along the Z-axis direction;
the slide block guide rails (17) are arranged on two sides of the frame (11) and are used for being matched and connected with the left slide block (20) and the right slide block (22) in a sliding manner;
the XY plane positioning unit includes:
a plurality of positioning holes (51) provided on the chip (5); a plurality of positioning pins (52) which are arranged on the lower surface of the positioning plate (2) and are arranged corresponding to the plurality of positioning holes (51); when the refrigerating sheet assembly (12) supports the chip (5) to move towards the positioning plate (2) along the Z-axis direction, the positioning hole (51) is inserted into the positioning pin (52);
a push pin (16) rotatably connected to the base (3), and a push pin groove (161) is formed in the chip (5); when the refrigerating sheet assembly (12) supports the chip (5) to move towards the positioning plate (2) along the Z-axis direction, the pushing pin (16) pushes the chip (5) in the pushing pin groove (161) to align the positioning hole (51) towards the positioning pin (52).
2. The die table positioning device of claim 1, further comprising a die in-out unit;
when the chip tray (4) extends out of the positioning device in the unloading position, the chip tray is used for taking and placing chips (5);
when the bin is in the storage space, the chip (5) is positioned below the positioning plate (2).
3. The die table positioning apparatus of claim 2, wherein the die access unit comprises:
the frame (11) is used for accommodating the chip tray (4), and a guide groove (6) is formed in the inner side of the frame (11) along the direction of entering and exiting the bin;
the chip tray (4) is conveyed between the discharging position and the feeding position along the guide groove (6) by the first motor (10) and the conveying mechanism.
4. A die table positioning device according to claim 3, characterized in that the first motor (10) is fixed to the frame (11) by means of a motor fixing seat (9); the conveying mechanism comprises a gear (7) and a rack (8), the gear (7) is arranged on an output shaft of a first motor (10), and the rack (8) is arranged on the chip tray (4); a guide rail (41) which is matched with the guide groove (6) to slide is arranged on the chip tray (4); when the first motor (10) rotates, the gear (7) is driven to rotate, and the rack (8) drives the chip tray (4) to move along the guide groove (6).
5. The chip station positioning device according to claim 1, wherein the cooling fin assembly (12) is provided with a plurality of holes, the holes are fixedly connected to the base (3) through pins which are cooperatively arranged at corresponding positions of the left slider (20) and the right slider (22), and elastic elements are arranged on the pins.
6. The die table positioning device according to claim 1, wherein the rotating shaft (18) of the push pin (16) is fixed on the base (3), a round hole is formed in the middle of the push pin (16) and can rotate around the rotating shaft (18), one end of the push pin (16) is of a spherical structure (31) and can slide along the guide plate (19), the guide plate (19) is fixed on the frame (11), the tension spring (15) is mounted at the bottom of the other end of the push pin (16), the push pin is connected to the base (3) through the tension spring (15), and the guide plate (19) is of a variable-section curved shape and is fixed on the frame (11).
7. The die table positioning device according to claim 6, wherein the power unit is mounted on a lifting fixing seat (29), and the lifting fixing seat (29) is fixedly connected below the frame (11);
the power unit includes:
the second motor (23) is fixedly arranged on the lifting fixing seat (29) through a motor mounting seat (24);
and the lifting chute plate (21) is in sliding connection with the base (3), and the base (3) is driven to move in the Z-axis direction by the rotation of the second motor (23).
8. The die table positioning device according to claim 7, characterized in that the output shaft of the second motor (23) is connected with a screw (28) through a coupling (25); a nut (27) is arranged on the screw rod (28), and the nut (27) is fixedly connected to the lifting chute plate (21); a chute inclined hole (30) is formed in the lifting chute plate (21), and the chute inclined hole (30) is in sliding connection with a cylindrical shaft on the base (3);
when the second motor (23) rotates, the screw rod (28) is driven to axially and linearly move, the nut (27) drives the lifting chute plate (21) to axially and linearly move, and the lifting chute plate (21) pushes the base (3) to move along the Z-axis direction through the chute inclined hole (30).
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| CN201811616855.1A CN109612996B (en) | 2018-12-27 | 2018-12-27 | Chip table positioning device |
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| CN201811616855.1A CN109612996B (en) | 2018-12-27 | 2018-12-27 | Chip table positioning device |
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| CN109612996A CN109612996A (en) | 2019-04-12 |
| CN109612996B true CN109612996B (en) | 2024-02-13 |
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|---|---|---|---|---|
| CN111579766B (en) * | 2020-05-25 | 2021-06-11 | 成都微康生物科技有限公司 | Disc-type microfluidic fluorescence immunoassay analyzer and immunoassay item testing method |
| CN114247493B (en) * | 2020-10-20 | 2023-06-27 | 深圳铭毅智造科技有限公司 | Chip fixing device for chemical reaction |
| CN112518403B (en) * | 2020-11-26 | 2022-09-16 | 上海航天设备制造总厂有限公司 | Clamping device and clamping method for large component |
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| CN115552249A (en) * | 2021-04-29 | 2022-12-30 | 京东方科技集团股份有限公司 | Warehouse in and out structure of analysis device, analysis device and analysis system |
| CN114672884A (en) * | 2022-03-28 | 2022-06-28 | 北京寻因生物科技有限公司 | Warehouse-in and warehouse-out component and single cell library preparation system |
| CN117302942A (en) * | 2022-06-24 | 2023-12-29 | 深圳拜尔洛克生物技术有限公司 | Biochip mobile device |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1558217A (en) * | 2004-02-02 | 2004-12-29 | 北京航空航天大学 | Automatic alignment apparatus for plastic microflow control chip |
| CN201145728Y (en) * | 2007-11-27 | 2008-11-05 | 比亚迪股份有限公司 | Apparatus for testing chip |
| CN102010817A (en) * | 2010-08-06 | 2011-04-13 | 博奥生物有限公司 | Chip automatic loading device of microarray chip scanner |
| CN103367208A (en) * | 2013-07-02 | 2013-10-23 | 华中科技大学 | Back bonding platform for superchip |
| CN104903697A (en) * | 2012-12-26 | 2015-09-09 | 文塔纳医疗系统公司 | Automated specimen processing systems and methods of aligning and transporting specimen-bearing microscope slides |
| WO2016111374A1 (en) * | 2015-01-09 | 2016-07-14 | Tokyo Electron Limited | Joint apparatus, joint system, and joint method |
| CN105772120A (en) * | 2016-03-07 | 2016-07-20 | 北京同方生物芯片技术有限公司 | Batched bonding packaging method for polymeric biochips and positioning device |
| CN207594546U (en) * | 2017-11-10 | 2018-07-10 | 东信和平科技股份有限公司 | A kind of automatic positioning equipment |
| CN109022274A (en) * | 2017-06-08 | 2018-12-18 | 北京万泰生物药业股份有限公司 | Micro-fluidic chip, chip steerable system, micro fluidic device and method for extracting nucleic acid |
| CN210180926U (en) * | 2018-12-27 | 2020-03-24 | 赛纳生物科技(北京)有限公司 | Chip platform positioner |
-
2018
- 2018-12-27 CN CN201811616855.1A patent/CN109612996B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1558217A (en) * | 2004-02-02 | 2004-12-29 | 北京航空航天大学 | Automatic alignment apparatus for plastic microflow control chip |
| CN201145728Y (en) * | 2007-11-27 | 2008-11-05 | 比亚迪股份有限公司 | Apparatus for testing chip |
| CN102010817A (en) * | 2010-08-06 | 2011-04-13 | 博奥生物有限公司 | Chip automatic loading device of microarray chip scanner |
| CN104903697A (en) * | 2012-12-26 | 2015-09-09 | 文塔纳医疗系统公司 | Automated specimen processing systems and methods of aligning and transporting specimen-bearing microscope slides |
| CN103367208A (en) * | 2013-07-02 | 2013-10-23 | 华中科技大学 | Back bonding platform for superchip |
| WO2016111374A1 (en) * | 2015-01-09 | 2016-07-14 | Tokyo Electron Limited | Joint apparatus, joint system, and joint method |
| CN105772120A (en) * | 2016-03-07 | 2016-07-20 | 北京同方生物芯片技术有限公司 | Batched bonding packaging method for polymeric biochips and positioning device |
| CN109022274A (en) * | 2017-06-08 | 2018-12-18 | 北京万泰生物药业股份有限公司 | Micro-fluidic chip, chip steerable system, micro fluidic device and method for extracting nucleic acid |
| CN207594546U (en) * | 2017-11-10 | 2018-07-10 | 东信和平科技股份有限公司 | A kind of automatic positioning equipment |
| CN210180926U (en) * | 2018-12-27 | 2020-03-24 | 赛纳生物科技(北京)有限公司 | Chip platform positioner |
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