CN109602721B

CN109602721B - Ganoderma lucidum whole plant essence soft capsule for expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor

Info

Publication number: CN109602721B
Application number: CN201910056237.4A
Authority: CN
Inventors: 尤流水
Original assignee: Hainan Xiancao Nanzhi Biotechnology Co ltd
Current assignee: Hainan Xiancao Nanzhi Biotechnology Co ltd
Priority date: 2019-01-22
Filing date: 2019-01-22
Publication date: 2021-04-02
Anticipated expiration: 2039-01-22
Also published as: CN109602721A

Abstract

The invention discloses a lucid ganoderma whole herb essence soft capsule for expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor, which comprises the following components in parts by weight: 60-70 parts of ganoderma lucidum extract, 0.2-0.7 part of ginkgo leaf extract, 0.2-0.5 part of semen allii tuberosi extract, 6-8 parts of radix puerariae powder, 1-2 parts of acerola powder, 2-3 parts of wall-broken ganoderma lucidum spore powder, 5-8 parts of ganoderma lucidum spore oil, 1-2 parts of soybean lecithin, 2-3 parts of beeswax, 2-5 parts of soybean oil, 1-3 parts of gelatin and 3-6 parts of glycerol. The soft capsule can obviously reduce the contents of glutamic-pyruvic transaminase, glutamic-oxalacetic transaminase, triglyceride and hepatic malondialdehyde in blood serum of an alcohol model mouse, improve the content of glutathione in hepatic tissue, obviously improve the white cell count of a radiation mouse, has the tumor inhibition rate of 35-76% on H22 tumor-bearing mice, and is a health food with obvious functions of expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor.

Description

Ganoderma lucidum whole plant essence soft capsule for expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor

Technical Field

The invention relates to a ganoderma lucidum whole plant essence soft capsule for expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor, belonging to the technical field of health-care food.

Background

Ganoderma lucidum is a medicinal and edible fungus, has rich pharmacological components, mainly comprises ganoderan, Ganoderma lucidum polypeptide, triterpenes and microelements, etc., has the effects of preventing various diseases, resisting cancer, enhancing human immunity, etc., so various health products taking Ganoderma lucidum as the main raw material are popular.

Chinese patent with application number CN201310278742.6 discloses a compound soft capsule of Ganoderma lucidum fine powder and a preparation method thereof, which comprises 1-300 parts of Ganoderma lucidum fine powder, 1-50 parts of lycopene, 1-50 parts of grifola frondosa polysaccharide and 1-500 parts of safflower seed oil. The soft capsule can cover the uncomfortable taste of contents, effectively improve the stability of the lycopene and the safflower seed oil, facilitate the ingestion and the complete absorption of nutritional health-care components, fully exert the effects of resisting inflammation, easing pain, reducing toxicity, promoting wound repair, regulating immunity, inhibiting tumor, resisting cancer, hypertension, hyperlipidemia and cardiovascular diseases, delaying aging, improving liver function, balancing and regulating organisms and the like, but still need to be further improved in the health-care effects of resisting radiation, resisting tumor and the like.

Disclosure of Invention

Aiming at the defects in the prior art, the invention provides a ganoderma lucidum whole plant essence soft capsule which can expel toxin, protect liver, improve radiation resistance and inhibit tumor.

The technical scheme adopted by the invention is as follows:

a ganoderma lucidum whole plant essence soft capsule for expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor comprises the following components in parts by weight: 60-70 parts of ganoderma lucidum extract, 0.2-0.7 part of ginkgo leaf extract, 0.2-0.5 part of semen allii tuberosi extract, 6-8 parts of radix puerariae powder, 1-2 parts of acerola cherry powder, 2-3 parts of wall-broken ganoderma lucidum spore powder, 5-8 parts of ganoderma lucidum spore oil, 1-2 parts of soybean lecithin, 2-3 parts of beeswax, 2-5 parts of soybean oil, 1-3 parts of gelatin and 3-6 parts of glycerol.

Preferably, the ganoderma lucidum whole plant essence soft capsule for expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor comprises the following components in parts by weight: 70 parts of ganoderma lucidum extract, 0.7 part of ginkgo leaf extract, 0.5 part of Chinese chive seed extract, 8 parts of kudzu root powder, 2 parts of acerola cherry fruit powder, 3 parts of wall-broken ganoderma lucidum spore powder, 8 parts of ganoderma lucidum spore oil, 2 parts of soybean lecithin, 3 parts of beeswax, 5 parts of soybean oil, 3 parts of gelatin and 6 parts of glycerol.

Preferably, the ginkgo biloba extract is prepared by the following method: cleaning ginkgo leaves, adding 1-2 times of water, adjusting the pH value to 3-4, soaking for 20-30 min at 70-80 ℃, taking out the ginkgo leaves, drying, crushing, adding an ethanol solution with the mass concentration of 60-70%, leaching for 30-60 min at 70-80 ℃, filtering, concentrating the filtrate to 20-30% of the original volume to obtain a concentrate, adding water into the concentrate according to the material-to-liquid ratio of 1 (1-3), adjusting the pH value to 5-6, soaking for 30-45 min at 50-55 ℃, filtering, concentrating and drying the filtrate to obtain the ginkgo leaf extract.

Preferably, the semen allii tuberosi extract is prepared by the following method:

1) crushing the Chinese chives seeds, mixing the Chinese chives seeds, water and yeast according to the mass ratio of 1 (0.6-0.7) to (0.02-0.05), fermenting for 3-8 days at room temperature in a sealing manner, and drying in vacuum until the water content is less than or equal to 4% to obtain pretreated Chinese chives seed powder;

2) according to the material-liquid ratio of 1 (3-5), performing reflux extraction on the preprocessed semen allii tuberosi powder for 1-3 times by using ethanol with the mass concentration of 60-70%, performing reflux extraction for 1-1.5 h each time, filtering, combining filtrates, concentrating the filtrate under reduced pressure to the relative density of 1.15-1.25, and recovering ethanol to obtain a thick extract; and (3) freeze-drying the thick extract for 1-2 hours at the temperature of-10 to-15 ℃ to obtain the semen allii tuberosi extract.

The invention also provides a preparation method of the ganoderma lucidum whole plant essence soft capsule for expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor, which comprises the following preparation steps:

1) preparing glue solution: firstly, adding water into gelatin for soaking the gelatin to swell, adding water into glycerol for mixing and heating to 40-50 ℃, then adding the swollen gelatin into the glycerol, heating to 70-80 ℃, stirring and decocting for 1-2 hours, and concentrating under reduced pressure until the water content is less than 35% to obtain a glue solution;

2) preparation of the contents: uniformly mixing soybean oil, beeswax and the semen allii tuberosi extract, heating and stirring for 30-45 min at 80-85 ℃, then cooling to 5-10 ℃, adding soybean lecithin, uniformly stirring, adding the ganoderma lucidum extract and the ganoderma lucidum spore oil at 34-45 ℃, mixing and stirring for 20-30 min, adding acerola cherry powder and pueraria powder, uniformly mixing, adding the ginkgo leaf extract, grinding and homogenizing by a colloid mill, standing for 30-60 min at 5-10 ℃, then mixing with a glue solution, and pressing into a soft capsule; wherein the pressing conditions comprise a gluing temperature of 55-75 ℃, a spraying temperature of 45-55 ℃ and a humidity of 45-55%;

3) shaping the pressed soft capsule at the temperature of 25-30 ℃ and the relative humidity of 35-40% for 2-4 h, washing the pill, and finally drying for 18-24 h under the conditions that the temperature is 30-40 ℃ and the humidity is less than or equal to 35%.

Preferably, the ganoderma lucidum whole plant essence soft capsule for expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor comprises the following preparation steps:

1) preparing glue solution: firstly, adding water into gelatin for soaking to swell the gelatin, adding water into glycerol for mixing and heating to 50 ℃, then adding the swollen gelatin into the glycerol, heating to 80 ℃, stirring and decocting for 2 hours, and concentrating under reduced pressure until the water content is less than 35% to obtain a gelatin solution;

2) preparation of the contents: mixing soybean oil, Cera flava and semen Allii Tuberosi extract, heating and stirring at 85 deg.C for 45min, cooling to 10 deg.C, adding soybean lecithin, stirring, adding Ganoderma extract and Ganoderma spore oil at 45 deg.C, mixing and stirring for 30min, adding acerola cherry fruit powder and radix Puerariae powder, mixing, adding folium Ginkgo extract, grinding with colloid mill, homogenizing, standing at 10 deg.C for 60min, mixing with glue solution, and making into soft capsule; wherein the pressing conditions are that the gluing temperature is 75 ℃, the spraying temperature is 55 ℃, and the humidity is 55%;

3) shaping the pressed soft capsule at 30 deg.C and relative humidity of 40% for 4 hr, washing, and drying at 40 deg.C and humidity of less than or equal to 35% for 24 hr.

Compared with the prior art, the invention has the beneficial effects that:

the soft capsule can obviously reduce the activities of glutamic-pyruvic transaminase (ALT) and glutamic-oxalacetic transaminase (AST) of blood serum of an alcohol model mouse, the content of Triglyceride (TG) and the content of hepatic malondialdehyde, and improve the content of hepatic glutathione, which shows that the soft capsule has obvious protection effect on liver injury induced by alcohol.

The soft capsule can obviously improve the white blood cell count of a radiated mouse, and shows that the soft capsule prepared by the invention has a certain radiation resistance effect and the effect is obviously superior to that of a comparative example.

The tumor inhibition rate of the soft capsule reaches 35-76%, which shows that the soft capsule has a certain anti-tumor effect.

In conclusion, the health food with obvious functions of expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor is prepared by the synergistic effect of the components.

Detailed Description

The present invention will be described in further detail with reference to the following embodiments.

The experimental methods used in the examples of the present invention are all conventional methods unless otherwise specified.

The ganoderma lucidum extract is ganoderma lucidum extract powder obtained by the conventional process steps of drying ganoderma lucidum sporocarp, extracting with alcohol, concentrating in vacuum, spray drying and the like, and mainly comprises ganoderma lucidum triterpene compounds and ganoderma lucidum polysaccharide.

Example 1

A ganoderma lucidum whole plant essence soft capsule for expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor comprises the following components in parts by weight: 60 parts of ganoderma lucidum extract, 0.2 part of ginkgo leaf extract, 0.2 part of semen allii tuberosi extract, 6 parts of kudzu root powder, 1 part of acerola cherry powder, 2 parts of wall-broken ganoderma lucidum spore powder, 5 parts of ganoderma lucidum spore oil, 1 part of soybean lecithin, 2 parts of beeswax, 2 parts of soybean oil, 1 part of gelatin and 3 parts of glycerol.

The ginkgo leaf extract is prepared by the following method: cleaning folium Ginkgo, drying, pulverizing, adding 60% ethanol solution, extracting at 70 deg.C for 30min, filtering, concentrating the filtrate to 20% of the original volume to obtain concentrate, and drying to obtain folium Ginkgo extract.

The semen allii tuberosi extract is prepared by the following method: pulverizing semen Allii Tuberosi, extracting with 60% ethanol at a material-to-liquid ratio of 1:3 under reflux for 3 times, each time for 1 hr, filtering, mixing filtrates, concentrating the filtrate under reduced pressure to relative density of 1.15, and recovering ethanol to obtain soft extract; freeze drying the thick extract at-10 deg.C for 1 hr to obtain semen Allii Tuberosi extract.

The preparation method of the ganoderma lucidum whole plant essence soft capsule for expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor comprises the following preparation steps:

1) preparing glue solution: firstly, adding water into gelatin for soaking to swell the gelatin, adding water into glycerol for mixing and heating to 40 ℃, then adding the swollen gelatin into the glycerol, heating to 70 ℃, stirring and decocting for 1h, and concentrating under reduced pressure until the water content is less than 35% to obtain a gelatin solution;

2) preparation of the contents: mixing soybean oil, Cera flava, semen Allii Tuberosi extract, soybean lecithin, Ganoderma extract, Ganoderma spore oil, acerola cherry fruit powder, radix Puerariae powder and folium Ginkgo extract, grinding with colloid mill, homogenizing, mixing with glue solution, and making into soft capsule; wherein the pressing conditions are that the gluing temperature is 55 ℃, the spraying temperature is 45 ℃ and the humidity is 45%;

3) shaping the pressed soft capsule at 25 deg.C and 35% relative humidity for 2 hr, washing, and drying at 30 deg.C and humidity no more than 35% for 18 hr.

Example 2

The difference between the example 2 and the example 1 is that the contents of the components are as follows:

70 parts of ganoderma lucidum extract, 0.7 part of ginkgo leaf extract, 0.5 part of Chinese chive seed extract, 8 parts of kudzu root powder, 2 parts of acerola cherry fruit powder, 3 parts of wall-broken ganoderma lucidum spore powder, 8 parts of ganoderma lucidum spore oil, 2 parts of soybean lecithin, 3 parts of beeswax, 5 parts of soybean oil, 3 parts of gelatin and 6 parts of glycerol.

Example 3

Example 3 differs from example 2 in that,

the ginkgo leaf extract is prepared by the following method: cleaning folium Ginkgo, adding 1 volume of water, adjusting pH to 3, soaking at 70 deg.C for 20min, taking out folium Ginkgo, drying, pulverizing, adding 60% ethanol solution, extracting at 70 deg.C for 30min, filtering, concentrating the filtrate to 20% of the original volume to obtain concentrate, adding water into the concentrate according to the material-liquid ratio of 1:1, adjusting pH to 5, soaking at 50 deg.C for 30min, filtering, concentrating the filtrate, and drying to obtain folium Ginkgo extract.

The semen allii tuberosi extract is prepared by the following method:

1) crushing the semen allii tuberosi, mixing the semen allii tuberosi, water and yeast according to the mass ratio of 1:0.6:0.02, sealing and fermenting for 3 days at room temperature, and performing vacuum drying until the water content is less than or equal to 4% to obtain pretreated semen allii tuberosi powder;

2) extracting the preprocessed semen Allii Tuberosi powder with 60% ethanol at a material-to-liquid ratio of 1:3 under reflux for 1 time, extracting under reflux for 1h, filtering, mixing filtrates, concentrating the filtrate under reduced pressure to relative density of 1.15, and recovering ethanol to obtain soft extract; freeze drying the thick extract at-10 deg.C for 1 hr to obtain semen Allii Tuberosi extract.

Example 4

Example 4 differs from example 3 in that,

the ginkgo leaf extract is prepared by the following method: cleaning folium Ginkgo, adding 2 times of water, adjusting pH to 4, soaking at 80 deg.C for 30min, taking out folium Ginkgo, drying, pulverizing, adding 70% ethanol solution, extracting at 80 deg.C for 60min, filtering, concentrating the filtrate to 30% of the original volume to obtain concentrate, adding water into the concentrate according to the material-liquid ratio of 1:3, adjusting pH to 6, soaking at 55 deg.C for 45min, filtering, concentrating the filtrate, and drying to obtain folium Ginkgo extract.

The semen allii tuberosi extract is prepared by the following method:

1) crushing the semen allii tuberosi, mixing the semen allii tuberosi, water and yeast according to the mass ratio of 1:0.7:0.05, sealing and fermenting for 3 days at room temperature, and performing vacuum drying until the water content is less than or equal to 4% to obtain pretreated semen allii tuberosi powder;

2) extracting the pretreated semen Allii Tuberosi powder with 70% ethanol at a ratio of 1:5 under reflux for 3 times, each time for 1.5 hr, filtering, mixing filtrates, concentrating the filtrate under reduced pressure to relative density of 1.25, and recovering ethanol to obtain soft extract; freeze drying the thick extract at-15 deg.C for 2 hr to obtain semen Allii Tuberosi extract.

Example 5

Example 5 differs from example 4 in that,

2) preparation of the contents: mixing soybean oil, Cera flava and semen Allii Tuberosi extract, heating at 80 deg.C under stirring for 30min, cooling to 5 deg.C, adding soybean lecithin, stirring, adding Ganoderma extract and Ganoderma spore oil at 34 deg.C, mixing, stirring for 20min, adding acerola cherry powder and radix Puerariae powder, mixing, adding folium Ginkgo extract, grinding with colloid mill, homogenizing, standing at 5 deg.C for 30min, mixing with glue solution, and making into soft capsule; wherein the pressing conditions are that the gluing temperature is 75 ℃, the spraying temperature is 45 ℃ and the humidity is 45%;

Example 6

Example 6 differs from example 5 in that,

the ganoderma lucidum whole plant essence soft capsule for expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor comprises the following preparation steps:

Comparative example 1

Comparative example 1 is different from example 1 in that,

the content of the soft capsule does not contain semen Allii Tuberosi extract, soybean lecithin, acerola cherry fruit powder, radix Puerariae powder and folium Ginkgo extract.

Comparative example 2

Comparative example 2 differs from example 1 in that,

a ganoderma lucidum whole plant essence soft capsule comprises the following components in parts by weight: 60 parts of ganoderma lucidum extract, 0.1 part of ginkgo leaf extract, 0.1 part of Chinese chive seed extract, 5 parts of kudzu root powder, 0.5 part of acerola cherry powder, 5 parts of wall-broken ganoderma lucidum spore powder, 10 parts of ganoderma lucidum spore oil, 3 parts of soybean lecithin, 5 parts of beeswax, 10 parts of soybean oil, 3 parts of gelatin and 6 parts of glycerol.

Comparative example 3

Comparative example 3 differs from example 1 in that the leek seed extract was replaced with an extract of lycium barbarum.

Test example 1: the protective effect of the soft capsule of the invention on liver injury

1. Test method

110 clean grade ICR mice with the weight of 22-25 g are randomly divided into 11 groups, 10 mice are used in each group, the samples of the examples 1-6 and the samples of the comparative examples 1-3 are respectively administered to the groups 1-9, the administration amount is 20mg/kg of body weight, the samples are intragastrically administered for 1 time every day for 30 days, and the groups 10 and 11 are a model group and a normal group. The normal group and the model group were simultaneously administered with an equal amount of physiological saline for intragastric administration.

2 hours after the last test sample administration, 20mL/kg of distilled water is given to a normal group, 20mL/kg of 50% ethanol is given to other groups by intragastric administration, blood is taken from femoral artery after 18 hours of fasting, and serum is separated to detect the activity of alanine Aminotransferase (ALT), aspartate Aminotransferase (AST) and the content of Triglyceride (TG); dissecting and collecting liver, collecting part of liver, preparing 30% liver homogenate with 0.9% sodium chloride, and collecting homogenate for measuring malondialdehyde (MDA-TBA colorimetry); the other part of liver is made into 10% liver homogenate by using an M reagent in a glutathione kit for measuring the content of the total glutathione.

2. Test results

Group of	ALT(IU/L)	AST(IU/L)	TG(mmol/g)	Malondialdehyde (nmol/g)	Glutathione (mu mol/g)
						Normal group	38±3.3	130±13.6	1.53±0.23	37.7±3.3	0.98±0.11
Model set	160±12.7	289±15.7	3.23±0.56	77.7±6.7	0.48±0.13
						Example 1	102±9.9	210±10.8	1.80±0.21	42.6±3.0	0.89±0.05
Example 2	100±8.0	197±10.0	1.89±0.17	37.9±2.17	0.90±0.12
						Example 3	88±5.8	160±7.0	1.67±0.12	30.9±1.22	0.92±0.13
Example 4	84±6.1	165±7.2	1.67±0.09	30.0±2.09	0.97±0.10
						Example 5	76±3.0	152±5.6	1.58±0.15	25.7±1.01	0.99±0.09
Example 6	63±3.6	150±5.5	1.55±0.22	20.9±1.23	0.96±0.17
						Comparative example 1	145±13.8	255±12.3	2.34±0.28	66.6±4.05	0.53±0.15
Comparative example 2	138±12.5	246±12.0	2.29±0.19	62.3±3.99	0.70±0.15
						Comparative example 3	125±10.0	240±13.9	2.11±0.35	69.0±1.86	0.62±0.21

Compared with the model group and the comparative example group, the example group can obviously reduce the serum glutamic-pyruvic transaminase (ALT), the glutamic-oxalacetic transaminase (AST) activity, the Triglyceride (TG) content and the hepatic tissue malondialdehyde content of the alcohol model mouse, improve the hepatic tissue glutathione content, and prompt that the sample of the example group has obvious protective effect on alcohol-induced hepatic injury.

Test example 2: the soft capsule of the invention has the radiation-resistant function

110 clean-grade Kunming mice with the weight of 28-32 g are randomly divided into 11 groups, 10 mice are used in each group, samples of examples 1-6 and comparative examples 1-3 are respectively administered to the 1 st-9 th groups, the administration amount is 20mg/kg of body weight, the tested samples are administered by intragastric gavage for 1 time every day for 34 days, and the 10 th and 11 th groups are a model group and a normal group. The normal group and the model group were simultaneously administered with an equal amount of physiological saline for intragastric administration.

Mice in the other groups received 5.5Gy after gavage for 1h on day 10, except for the normal group⁶⁰Co-gamma ray is irradiated to the whole body. The groups were bled from the orbit at day 3, day 10, day 17 and day 24 after irradiation, and the number of peripheral blood leukocytes in the mice was measured.

2. Test results

Model group mice in⁶⁰The white blood cell count was significantly lower than that of the normal group on days 3, 10, 17 and 24 after Co- γ irradiation; compared with the model group and the comparative example group, the white blood cell count of each group is obviously increased, which shows that the white blood cell count of the mice irradiated by each administration group gradually recovers and increases, and the soft capsule prepared by the invention has the radiation resistance effect.

Test example 3 antitumor Effect of the Soft Capsule of the present invention

1. The test method comprises the following steps:

molding: 4 weeks old mice were acclimatized for 3 days, each mouse was disinfected of skin at the right axilla, and inoculated with a suspension of H22 tumor cells (C ═ 1X 10)⁷mL), 0.2mL per inoculation. After 24 hours of molding, 10 groups were randomly divided, 10 specimens were administered to each group, 1 st to 9 th groups, respectively, the samples of examples 1 to 6 and comparative examples 1 to 3 at an administration amount of 20mg/kg body weight, and the test samples were administered by gavage 1 time per day for 15 days, with the 10 th group being a control group. The control group was also administered an equivalent amount of physiological saline for intragastric administration.

On the next day of drug withdrawal, each mouse was weighed and sacrificed, and the tumor mass was dissected off, weighed, and the tumor inhibition rate was calculated from the average tumor weight.

Tumor inhibition rate (%) (mean [ (control group average tumor weight-administration group average tumor weight)/control group average tumor weight ]. times.100%

2. And (3) test results:

group of	Body weight (g) before administration	Body weight (g) after administration	Tumor weight (g)	Tumor inhibition Rate (%)
					Control group	20.9±0.7	24.6±0.1	1.73±0.56	-
Example 1	20.4±0.2	25.2±0.2	1.50±0.21	35.6
					Example 2	20.3±0.1	25.7±0.3	1.49±0.17	40.3
Examples3	20.9±0.2	25.7±0.5	1.21±0.12	56.4
					Example 4	20.8±0.9	25.8±0.5	1.27±0.09	56.0
Example 5	20.9±0.1	26.3±0.2	1.08±0.15	62.4
					Example 6	21.5±0.3	28.5±0.1	0.90±0.22	76.9
Comparative example 1	20.7±0.5	24.6±0.1	1.74±0.28	13.8
					Comparative example 2	20.4±0.9	24.3±0.3	1.69±0.19	15.3
Comparative example 3	20.8±0.6	24.7±0.1	1.61±0.35	20.0

The results show that the tumor inhibition rate of the soft capsule reaches 35-76%, and the soft capsule has significant difference compared with a comparative example group and a control group; the soft capsule of the invention has certain inhibition effect on the tumor growth of H22 tumor-bearing mice.

The foregoing is a more detailed description of the present invention that is presented in conjunction with specific embodiments, and the practice of the invention is not to be considered limited to those descriptions. It will be apparent to those skilled in the art that a number of simple derivations or substitutions can be made without departing from the inventive concept.

Claims

1. A ganoderma lucidum whole plant essence soft capsule for expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor is characterized by comprising the following components in parts by weight: 60-70 parts of ganoderma lucidum extract, 0.2-0.7 part of ginkgo leaf extract, 0.2-0.5 part of semen allii tuberosi extract, 6-8 parts of radix puerariae powder, 1-2 parts of acerola powder, 2-3 parts of wall-broken ganoderma lucidum spore powder, 5-8 parts of ganoderma lucidum spore oil, 1-2 parts of soybean lecithin, 2-3 parts of beeswax, 2-5 parts of soybean oil, 1-3 parts of gelatin and 3-6 parts of glycerol;

the ginkgo leaf extract is prepared by the following method: cleaning ginkgo leaves, adding 1-2 times of water, adjusting the pH value to 3-4, soaking for 20-30 min at 70-80 ℃, taking out the ginkgo leaves, drying and crushing, adding an ethanol solution with the mass concentration of 60-70%, leaching for 30-60 min at 70-80 ℃, filtering, concentrating the filtrate to 20-30% of the original volume to obtain a concentrate, adding water into the concentrate according to the material-to-liquid ratio of 1 (1-3), adjusting the pH value to 5-6, soaking for 30-45 min at 50-55 ℃, filtering, concentrating and drying the filtrate to obtain a ginkgo leaf extract;

the semen allii tuberosi extract is prepared by the following method:

2) performing reflux extraction on the preprocessed semen allii tuberosi powder for 1-3 times by using ethanol with the mass concentration of 60-70% according to the material-liquid ratio of 1 (3-5), performing reflux extraction for 1-1.5 h each time, filtering, combining filtrates, concentrating the filtrate under reduced pressure to the relative density of 1.15-1.25, and recovering ethanol to obtain a thick extract; and (3) freeze-drying the thick extract for 1-2 hours at the temperature of-10 to-15 ℃ to obtain the semen allii tuberosi extract.

2. The soft capsule of ganoderma lucidum whole plant essence for expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor according to claim 1, which is characterized by comprising the following components in parts by weight: 70 parts of ganoderma lucidum extract, 0.7 part of ginkgo leaf extract, 0.5 part of Chinese chive seed extract, 8 parts of kudzu root powder, 2 parts of acerola cherry fruit powder, 3 parts of wall-broken ganoderma lucidum spore powder, 8 parts of ganoderma lucidum spore oil, 2 parts of soybean lecithin, 3 parts of beeswax, 5 parts of soybean oil, 3 parts of gelatin and 6 parts of glycerol.

3. The soft capsule of lucid ganoderma whole plant essence for expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor according to any one of claims 1-2, which is characterized by comprising the following preparation steps:

4. The soft capsule of ganoderma lucidum whole plant essence for expelling toxin, protecting liver, improving radiation resistance and inhibiting tumor according to claim 3, which is characterized by comprising the following preparation steps: