CN109602014A - 桃胶多糖包埋天然抗氧化剂组合物及其应用 - Google Patents
桃胶多糖包埋天然抗氧化剂组合物及其应用 Download PDFInfo
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- CN109602014A CN109602014A CN201811204764.7A CN201811204764A CN109602014A CN 109602014 A CN109602014 A CN 109602014A CN 201811204764 A CN201811204764 A CN 201811204764A CN 109602014 A CN109602014 A CN 109602014A
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- peach gum
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
本发明公开了一种桃胶多糖包埋天然抗氧化剂组合物及其应用,所述组合物可有效防止因单次大剂量饮酒导致的醉酒及醉酒后的相关机体健康危害。所述组合物按照下述步骤制得:在水溶液体系中,以桃胶多糖作为壁材微纳米化包埋天然抗氧化剂,制得所述组合物。优选的,所述组合物中,桃胶多糖的质量浓度不大于5%g/mL,最佳质量浓度为1%‑2.5%g/mL。本发明实施例通过桃胶多糖在胃肠道形成一道耐消化酶分解的保护屏障,防止或减少高浓度乙醇对胃肠粘膜的化学性损伤;通过桃胶多糖的微纳化包埋的天然抗氧化剂分子起到抑制乙醇代谢所致的氧化应激级联损伤,激活和增加体内乙醇脱氢酶、乙醛脱氢酶活性,促进乙醇代谢。
Description
技术领域
本发明涉及食品技术领域,特别涉及一种桃胶多糖包埋天然抗氧化剂组合物及其应用。
背景技术
目前,随着经济的发展,人们的物质生活日益丰富,各类酒精饮料充满消费市场,另一方面,由于中国酒文化的传承和流行,人们饮酒变得日益频繁,醉酒、酒精中毒、酒精肝等各种健康问题也随之而来,而如何预防醉酒成为健康饮酒的首要问题。
人饮酒后,乙醇在胃内吸收入血约占20%,约80%在小肠段吸收入血,进入人体内的乙醇除极少量未经代谢直接经由汗液和尿液的形式排出外,绝大部分乙醇需依次经过肝内的乙醇脱氢酶和乙醛脱氢酶催化分解。目前,食品领域用于解酒的主要是以葛根、枳椇子、甘草、蜂蜜等原料单独使用或配伍制成,其中部分产品显现出一定的乙醇脱氢酶或乙醛脱氢酶增效作用,从而加速机体代谢血中乙醇代谢分解。
在实现本发明的过程中,发明人发现现有技术至少存在以下问题:
食品领域用于解酒的产品对于一次性的大量饮酒导致的醉酒不能体现良好效果,并未达到实际意义上的预防醉酒的作用。
发明内容
为了解决现有技术的问题,本发明实施例提供了一种桃胶多糖包埋天然抗氧化剂组合物及其应用,所述组合物可有效防止因单次大剂量饮酒导致的醉酒及醉酒后的相关机体健康危害。所述技术方案如下:
一方面,本发明实施例提供了一种桃胶多糖包埋天然抗氧化剂组合物,所述组合物按照下述步骤制得:
在水溶液体系中,以桃胶多糖作为壁材微纳米化包埋天然抗氧化剂,制得所述组合物。
所述桃胶多糖是利用酸解法、超声波提取法、水提醇沉及Sevage去蛋白法等方式的至少一种从桃树或山桃树采收的原桃胶中提取获得。提取所得桃胶多糖特征在于其分子量在3万-600万,主要由阿拉伯糖、半乳糖、鼠李糖、甘露糖等单糖分子以β-糖苷键连接。其中分子量在10万-50万的桃胶多糖防醉酒应用效果最佳。优选的,所述组合物中,桃胶多糖的质量浓度不大于5%(g/mL)(桃胶多糖的质量除以组合物的体积),最佳质量浓度为1%-2.5%(g/mL)。
所述天然抗氧化剂为茶多酚及其衍生物、番茄红素、姜黄素、葛花黄酮、甘草黄酮、葛根黄酮、大豆异黄酮、高良姜黄酮、桑葚花青素、二氢杨梅素、白藜芦醇或虾青素中的至少一种。优选的,所述茶多酚及其衍生物为表没食子儿茶素没食子酸酯。
优选的,所述壁材还包括明胶或乳清蛋白。
优选的,所述以桃胶多糖作为壁材纳米化包埋天然抗氧化剂的方法为本领域公知的高压均质乳化法、高速剪切分散乳化法、复合凝聚法中的至少一种,使所述天然抗氧化剂均匀地分散、并以桃胶多糖及其他成膜组分(如明胶或乳清蛋白)为壁材形成微纳米级的稳定状态。
进一步优选的,所述壁材还包括明胶,所述以桃胶多糖和明胶作为壁材纳米化包埋天然抗氧化剂的方法为复合凝聚法,所述桃胶多糖和明胶的用量为(0.5-3):(0.5-3),如1:1。
另一方面,本发明实施例还提供了所述组合物在防醉酒产品中的应用。
桃胶是指蔷薇科植物桃Amygdalus persica L.或山桃Amygdalus davidiana(Carrière)de Vos ex Henry树皮因机械损伤或虫蛀破坏而分泌出来的树脂,是我国传统药食两用资源,具有和血,通淋,止痢之功效。可用于痢疾,石淋,糖尿病,血瘕,乳糜尿,腹痛的治疗。桃胶是一种杂多糖并与蛋白质复合,具有吸水溶胀及缓释的优良特性。现代食品化学分析研究证实,桃胶多糖主要是由L-阿拉伯糖、D-半乳糖、D-木糖、D-葡萄糖醛酸、L-鼠李糖等单糖分子组成,体外消化液模拟试验证明人体消化系统中的消化酶类不能催化桃胶多糖的降解。我国桃胶资源丰富,对桃胶进行高附加值的开发利用具有重要意义。到目前为止,现有技术尚未发现将桃胶多糖用于预防醉酒及解酒作用。
抗氧化剂是一类能帮助捕获并中和自由基,从而祛除自由基对人体损害的一类物质。抗氧化剂按来源分为人工合成与天然抗氧化剂。香辛料、中草药、茶叶、谷物及蔬菜食品是天然抗氧化剂的主要来源,其中多酚-黄酮类物质及类胡萝卜素类物质是天然抗氧化剂的主要化学构成。天然抗氧化剂能够起到清除活性氧自由基、增强体内抗氧化酶活性、阻断脂质过氧化链式反应及减少DNA损伤等多方面功能,对人体健康有重要意义。抗氧化剂用量应符合《食品安全国家标准-食品添加剂使用标准》最大限量标准。
本发明实施例提供的技术方案带来的有益效果是:
本发明实施例通过桃胶多糖在胃肠道形成一道耐消化酶分解的保护屏障,防止酒精饮料中的乙醇分子单次大剂量进入血液循环,防止或减少高浓度乙醇对胃肠粘膜的化学性损伤;同时,通过桃胶多糖的微纳化包埋的天然抗氧化剂分子起到抑制乙醇代谢所致的氧化应激级联损伤,激活和增加体内乙醇脱氢酶、乙醛脱氢酶活性,促进乙醇代谢。本发明实施例提供的所述组合物可有效防止因单次大剂量饮酒导致的醉酒及醉酒后的相关机体健康危害。
附图说明
为了更清楚地说明本发明实施例中的技术方案,下面将对实施例描述中所需要使用的附图作简单地介绍,显而易见地,下面描述中的附图仅仅是本发明的一些实施例,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据这些附图获得其他的附图。
图1是本发明实施例1提供的桃胶多糖对体外模拟胃肠道乙醇吸收的影响;
图2是醉酒实验小鼠典型胃粘膜外观对照图。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚,下面将结合附图对本发明实施方式作进一步地详细描述。
一方面,本发明实施例提供了一种桃胶多糖包埋天然抗氧化剂组合物,所述组合物按照下述步骤制得:
在水溶液体系中,以桃胶多糖作为壁材微纳米化包埋天然抗氧化剂,制得所述组合物。
所述桃胶多糖是利用酸解法、超声波提取法、水提醇沉及Sevage去蛋白法等方式的至少一种从桃树或山桃树采收的原桃胶中提取获得。提取所得桃胶多糖特征在于其分子量在3万-600万,主要由阿拉伯糖、半乳糖、鼠李糖、甘露糖等单糖分子以β-糖苷键连接。其中分子量在10万-50万的桃胶多糖防醉酒应用效果最佳。优选的,所述组合物中,桃胶多糖的质量浓度不大于5%(g/mL)(桃胶多糖的质量除以组合物的体积),最佳质量浓度为1%-2.5%(g/mL)。
所述天然抗氧化剂为茶多酚及其衍生物、番茄红素、姜黄素、葛花黄酮、甘草黄酮、葛根黄酮、大豆异黄酮、高良姜黄酮、桑葚花青素、二氢杨梅素、白藜芦醇或虾青素中的至少一种。优选的,所述茶多酚及其衍生物为表没食子儿茶素没食子酸酯。
优选的,所述壁材还包括明胶或乳清蛋白。
优选的,所述以桃胶多糖作为壁材纳米化包埋天然抗氧化剂的方法为本领域公知的高压均质乳化法、高速剪切分散乳化法、复合凝聚法中的至少一种,使所述天然抗氧化剂均匀地分散、并以桃胶多糖及其他成膜组分(如明胶或乳清蛋白)为壁材形成微纳米级的稳定状态。
进一步优选的,所述壁材还包括明胶,所述以桃胶多糖和明胶作为壁材纳米化包埋天然抗氧化剂的方法为复合凝聚法,所述桃胶多糖和明胶的用量为(0.5-3):(0.5-3),例如1:1。
另一方面,本发明实施例还提供了所述组合物在防醉酒产品中的应用。所述组合物用做防醉酒产品时,在饮酒前30min服用,剂量1~2ml/kg,如有必要可增加服用量。
本发明实施例提供的所述组合物可有效防止因单次大剂量饮酒导致的醉酒及醉酒后的相关机体健康危害。
本发明实施例所用原料药或辅料均可由市场购得。
先配好一定浓度的明胶和桃胶多糖水溶液,加入预先溶解的抗氧化剂。在15000-20000r/min下用高速分散剪切机高速均质乳化2-5min。用磁力搅拌器在40-45℃左右、转速500r/min搅拌,并用10%的醋酸溶液缓慢调节体系p H至4.0-4.5,维持搅拌约2小时,然后以冰水浴将体系降温至约10℃以终止凝聚过程,再用碱溶液将体系pH调回中性,抗氧化剂微纳米化情况用显微镜观察,评估其外观和粒径等指征。
所得组合物中抗氧化剂包埋于桃胶多糖/明胶形成的壁材中,形态多呈圆形,大小分散均匀且透明,粒径500nm-150μm之间。
实施例1
以桃胶多糖-明胶为壁材复合凝聚包埋表没食子儿茶素没食子酸酯的防醉酒组合物的制备
桃树来源的原桃胶依次经热水浸提、Sevage法脱蛋白、乙醇沉淀及干燥工艺环节获得桃胶多糖。液相色谱分析显示,桃胶多糖由甘露糖、鼠李糖、半乳糖醛酸、葡萄糖、半乳糖、木糖、阿拉伯糖等组成,摩尔比为0.7:1.6:2.4:1.3:32.9:28.6:22.5,半乳糖、阿拉伯糖和木糖是构成主链的主要单糖。红外光谱显示桃胶多糖具有β-糖苷键。
采用复合凝聚法制备桃胶多糖/明胶微胶囊化表没食子儿茶素没食子酸酯,即1000ml超纯水中加入桃胶多糖15g和明胶15g,维持约60℃加热并持续搅拌至完全溶解,加入表没食子儿茶素没食子酸酯0.4g,充分溶解后,高速剪切机分散乳化,而后以pH 4.0、搅拌速度为300rpm为参数复合凝聚2h,凝聚结束后调整pH至6.5~7即得防醉酒组合物约1000mL,所述组合物中,桃胶多糖的质量浓度为1.5%g/mL,抗氧化剂表没食子儿茶素没食子酸酯的用量为0.4g/mL组合物。
实施例2
桃胶多糖-明胶为壁材复合凝聚包埋番茄红素的防醉酒组合物的制备
制备工艺与实施例1基本一致,不同之处在于番茄红素添加量为0.04g/1000mL组合物。
实施例3
桃胶多糖-明胶为壁材复合凝聚包埋姜黄素的防醉酒组合物的制备
制备工艺与实施例1基本一致,不同之处在于姜黄素添加量为0.7g/1000mL组合物。
实施例4
桃胶多糖-明胶为壁材复合凝聚包埋甘草黄酮的防醉酒组合物的制备
制备工艺与实施例1基本一致,不同之处在于甘草黄酮添加量为0.2g/1000mL组合物。
以上实施例中抗氧化剂的用量不超过1g/mL组合物。
为了进一步表明本发明实施例提供的防醉酒组合物的性能,以实施例1~4中的组合物为例,对其进行试验,试验方法、试验数据及相关分析如下所示。
1、材料与方法
1.1动物
昆明小鼠,SPF级,25-28g,雄性,购自湖北省疾病预防控制中心,合格证号:SCXK(鄂)2015-0018。
1.2药物与试剂
阳性对照:力克保健液,辽宁力克制药有限公司;实施例1~4中制作的防醉酒组合物;食用乙醇溶液,配制成60%(v/v)浓度;其他试剂均为市售实验试剂。
2、方法
2.1体外模拟胃肠道乙醇吸收试验
以透析袋模拟胃肠道黏膜,在透析袋内加入人工胃液,将装有人工胃液的透析袋置于大烧杯中,并在大烧杯中加入生理盐水,通过将酒精溶液及不同浓度的桃胶多糖加入到透析袋内,定时取样检测烧杯内乙醇浓度,从而监测桃胶多糖对模拟机体胃肠道的酒精吸收的影响。乙醇浓度测定采用重铬酸钾还原法,检测反应液在610nm的吸光度,其中blank为空白对照组,PG为桃胶多糖。
2.2动物分组
正常组:给予生理盐水灌胃;
模型组:给予生理盐水灌胃;
阳性药组:给予力克保健液灌胃;
实施例1组:给予实施例1组合物灌胃;
实施例2组:给予实施例2组合物灌胃;
实施例3组:给予实施例3组合物灌胃;
实施例4组:给予实施例4组合物灌胃;
生理盐水及药物灌胃体积,按15mL/kg体重计算。
2.3小鼠解酒试验
昆明小鼠在SPF级动物房内适应性喂养1周,自由饮水进食。实验开始前禁食8h,选取小鼠称重标记后随机分组,分别设为正常组、模型组、阳性药组、实施例1~4组,每组各10只。预实验确定昆明小鼠致醉剂量(1.5ml/kg 60%v/v乙醇)。精确称量小鼠体重,按体重确定灌胃剂量,正常组和模型组给予生理盐水灌胃,其余各组依次灌胃不同剂量的受试药物。半小时后,除正常组外,各组按致醉量灌胃乙醇溶液(60%v/v),记录各组小鼠翻正反射消失及恢复的时间,3h后眼眶静脉取血,用于检测血清乙醇浓度,解刨小鼠,分离出小鼠胃部,观察小鼠胃粘膜损伤情况,分离小鼠肝组织用于生化指标检测。
2.4数据处理
数据采用方差分析,用多个实验组和一个模型组间均数的两两比较方法进行统计;对非正态或方差不齐的数据进行适当的变量转换,待满足正态或方差齐要求后,用转换后的数据进行统计;若变量转换后仍未达到正态或方差齐的目的,改用秩和检验进行统计。检验水平α=0.05。
3、实验结果
3.1图1所示为不同浓度桃胶多糖对体外模拟的胃肠道乙醇吸收的影响,可见,随着桃胶多糖浓度的增加,从透析袋内释放出乙醇的速度依次降低,表明桃胶多糖可在透析袋内侧形成屏障,包裹吸附乙醇分子,抑制乙醇分子扩散。
3.2动物实验防醉酒效果评价
防醉酒试验结果如表1所示。由表1可见,模型组小鼠的醉倒率为90%,各组未发现动物因醉酒死亡;与模型组比较,阳性组和各组合物组的醉倒率显著降低,且各组合物组略优于阳性药物组,各组合物组间差异不显著。
表1各组合物对昆明小鼠醉酒的效果
vs模型组,*P<0.05,**P<0.01。
各组小鼠血清乙醇浓度如表2所示,可见,模型组小鼠血清乙醇浓度显著升高,经阳性药物和各组合物组预处理后的小鼠血清乙醇含量显著下降,且各预处理组间未见显著差异。
表2各组合物对昆明小鼠血清乙醇含量的影响
vs模型组,*P<0.05,**P<0.01
3.2保护胃粘膜急性损伤评价
肉眼观察小鼠胃粘膜损伤情况,结果如图2所示。可见模型组小鼠胃粘膜有明显充血、糜烂并有局部溃疡。而经阳性药物和各组合物预处理的小鼠胃粘膜充血情况显著改善,基本未见溃疡,且各组合物的保护效果(如胃粘膜充血情况)要明显强于阳性药物组。
3.3护肝效果评价
分别测定了小鼠血清中丙二醛(MDA)含量及超氧化物歧化酶(SOD)活性,如表3所示,可见大剂量乙醇可致小鼠体内MDA集聚、抑制SOD活性,机体活性氧损伤明显加重,而经阳性药物或组合物预处理则能显著减少因乙醇导致的MDA积累,增强SOD活性加速机体清除乙醇代谢毒性产物。
表3各组合物对昆明小鼠血清MDA、SOD的影响
vs模型组,*P<0.05,**P<0.01
进一步地,对小鼠肝组织内乙醇脱氢酶(ADH)、乙醛脱氢酶(ALDH)含量进行了测定,发现阳性药物及各组合物能显著增加肝内ADH、ALDH合成,促进乙醇代谢分解。
表4各组合物对昆明小鼠肝组织ADH、ALDH的影响
vs模型组,*P<0.05,**P<0.01
以上所述仅为本发明的较佳实施例,并不用以限制本发明,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (9)
1.一种桃胶多糖包埋天然抗氧化剂组合物,其特征在于,所述组合物按照下述步骤制得:
在水溶液体系中,以桃胶多糖作为壁材微纳米化包埋天然抗氧化剂,制得所述组合物。
2.根据权利要求1所述的组合物,其特征在于,所述组合物中,所述桃胶多糖的质量浓度为1%-2.5%g/mL。
3.根据权利要求1所述的组合物,其特征在于,所述天然抗氧化剂为茶多酚及其衍生物、番茄红素、姜黄素、葛花黄酮、甘草黄酮、葛根黄酮、大豆异黄酮、高良姜黄酮、桑葚花青素、二氢杨梅素、白藜芦醇或虾青素中的至少一种。
4.根据权利要求3所述的组合物,其特征在于,所述茶多酚及其衍生物为表没食子儿茶素没食子酸酯。
5.根据权利要求1-3中任一项所述的组合物,其特征在于,所述壁材还包括明胶或乳清蛋白。
6.根据权利要求1-3中任一项所述的组合物,其特征在于,所述以桃胶多糖作为壁材纳米化包埋天然抗氧化剂的方法为高压均质乳化法、高速剪切分散乳化法、复合凝聚法中的至少一种。
7.根据权利要求6所述的组合物,其特征在于,所述壁材还包括明胶,所述以桃胶多糖和明胶作为壁材纳米化包埋天然抗氧化剂的方法为复合凝聚法,所述桃胶多糖和明胶的用量为(0.5-3):(0.5-3)。
8.根据权利要求7所述的组合物,其特征在于,所述复合凝聚法的具体步骤为:在超纯水中加入桃胶多糖和明胶,维持60℃加热并持续搅拌至完全溶解,加入天然抗氧化剂,充分溶解后,高速剪切机分散乳化,而后以pH 4.0、搅拌速度为300rpm为参数复合凝聚2h,凝聚结束后调整pH至6.5~7即得所述组合物。
9.权利要求1-8中任一项所述组合物在防醉酒产品中的应用。
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