CN109589389A - A kind of drug and preparation method thereof for treating leukaemia - Google Patents
A kind of drug and preparation method thereof for treating leukaemia Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of drugs and preparation method thereof for treating leukaemia, the drug of the treatment leukaemia is raw material by using the three Ten Herbs material such as Radix Salviae Miltiorrhizae, radix scrophulariae and carries out weight proportion appropriate, with Radix Salviae Miltiorrhizae, radix scrophulariae, Radix Codonopsis, Radix Notoginseng, Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Astragali, Poria cocos, fructus amomi, hawthorn, builds bent, Fructus Aurantii remodeling hemopoietic system；With vicious in kuh-seng, the coptis, mung bean, spina gleditsiae, folium isatidis, indigo naturalis, olibanum, myrrh, ox sulphur, red orpiment neutralizing blood；It is fallen with donkey-hide gelatin, colla carapacis et plastri testudinis, deer horn glue, iron, verdigris, lopseed, motherwort rehabilitation physiological tissue and organ, returns benign cycle；Detoxified with Radix Glycyrrhizae, and coordinating the drug actions of a prescription.By the four aspects mechanism of action, play the role for the treatment of leukaemia jointly.Data are shown: drug of the present invention is used to treat effective percentage 78% of leukaemia, obvious effective rate 69%, cure rate 63%, and good effect of the present invention, cure rate is high, low in cost, preparation method is simple, with wide application value.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, and in particular to a kind of drug and preparation method thereof for treating leukaemia.
Background technique
Leukaemia is a kind of candidate stem cell malignant clone disease.Clonal leukaemia cell because proliferation out of control, point
Change obstacle, apoptosis mechanism largely proliferation accumulation in marrow and other hematopoietic tissues such as to be obstructed, and infiltrates other non-hematopoietic tissues
And organ, while inhibiting normal hematopoiesis function.Clinical visible different degrees of anaemia, bleeding, infectious fever and liver, spleen, leaching
Fawn on enlargement and skeleton pain.It is reported that the disease incidence of China each department leukaemia accounts for the 6th in various tumours.By rise
The emergency of disease can be divided into leukemia.Acute leukemia cells differentiation is stuck in early stage, thin with original children early
Based on born of the same parents, disease is quickly grown, the course of disease several months.Chronic leukemia cell differentiation is preferable, based on inmature or mature cell, hair
Postpone slow, the course of disease several years.By sick cell series classification, the T and B of grain, single, red, macronucleus system including medullary system and Lymphatic System are thin
Born of the same parents system.Leukaemia is often clinically divided into lymphocytic leukemia, myelocytic leukemia, cell mixing leukaemia etc..Children and
The a lot of diseases of teenager's acute leukemia are hurried.Common onset symptoms include fever, progressive anaemia, significant hemorrhagic tendency
Or bone joint pain etc..The slow person of onset is in the majority with old and part Young patients, and the state of an illness is gradually in progress.In addition, small number of patients
It can twitch, blind, having a toothache, gum swelling, hydropericardium, double lower limb paraplegia etc. are onset symptoms.
About leukaemia, mainly have following a few class treatment methods at present: chemotherapy, targeted therapy, is exempted from radiotherapy
Epidemic disease treatment, stem cell transplantation etc..Although have certain therapeutic effect, need long-term treatment, side effect is big, and to patient with
The financial burden come is huge.Therefore, the Chinese medicine treatment leukemia medicament tool that development efficacy is good, cure rate is high, treatment cost is cheap
There is very positive realistic meaning.
Summary of the invention
In order to solve the above problems existing in the present technology, the present invention provides a kind of good effects, cure rate height, cost
Cheap, preparation method is simple, the drug for the treatment of leukaemia with application value and preparation method thereof.
The technical scheme adopted by the invention is as follows:
A kind of drug for treating leukaemia, raw material components include:
It is Radix Salviae Miltiorrhizae 24-36 parts by weight, radix scrophulariae 12-18 parts by weight, Radix Codonopsis 12-18 parts by weight, Radix Notoginseng 4.8-7.2 parts by weight, white
Art 12-18 parts by weight, Radix Angelicae Sinensis 8-12 parts by weight, Radix Astragali 12-18 parts by weight, Poria cocos 12-18 parts by weight, donkey-hide gelatin 4.8-7.2 weight
Part, colla carapacis et plastri testudinis 4.8-7.2 parts by weight, deer horn glue 4.8-7.2 parts by weight, fructus amomi 4.8-7.2 parts by weight, hawthorn 12-18 weight
Part builds bent 8-12 parts by weight, Fructus Aurantii 8-12 parts by weight, kuh-seng 12-18 parts by weight, coptis 8-12 parts by weight, mung bean 24-36 weight
Measure part, folium isatidis 8-12 parts by weight, indigo naturalis 8-12 parts by weight, olibanum 12-18 parts by weight, myrrh 12-18 parts by weight, ox sulphur
4.8-7.2 parts by weight, red orpiment 4.8-7.2 parts by weight, iron fall 8-12 parts by weight, verdigris 1.6-2.4 parts by weight, spina gleditsiae 24-36
Parts by weight, lopseed 12-18 parts by weight, motherwort 24-36 parts by weight, Radix Glycyrrhizae 12-18 parts by weight.
The raw material components of drug of the further preferably described treatment leukaemia include:
30 parts by weight of Radix Salviae Miltiorrhizae, 15 parts by weight of radix scrophulariae, 15 parts by weight of Radix Codonopsis, 6 parts by weight of Radix Notoginseng, 15 parts by weight of Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis
10 parts by weight, 15 parts by weight of Radix Astragali, 15 parts by weight of Poria cocos, 6 parts by weight of donkey-hide gelatin, 6 parts by weight of colla carapacis et plastri testudinis, 6 parts by weight of deer horn glue,
6 parts by weight of fructus amomi, 15 parts by weight of hawthorn build bent 10 parts by weight, 10 parts by weight of Fructus Aurantii, 15 parts by weight of kuh-seng, 10 weight of the coptis
Part, 30 parts by weight of mung bean, 10 parts by weight of folium isatidis, 10 parts by weight of indigo naturalis, 15 parts by weight of olibanum, 15 parts by weight of myrrh, ox sulphur 6
Parts by weight, 6 parts by weight of red orpiment, iron fall 10 parts by weight, 2 parts by weight of verdigris, 30 parts by weight of spina gleditsiae, 15 parts by weight of lopseed, benefit
30 parts by weight of Brittle Falsepimpernel Herb, 15 parts by weight of Radix Glycyrrhizae.
The drug is pill or paste.
The preparation method of the pill medicine, includes the following steps:
(1) each bulk pharmaceutical chemicals component is taken, wine toast processing is carried out, obtains wine toast medicinal material；
(2) step (1) the wine toast medicinal material is subjected to pulverization process, obtains each fine drug powder；
(3) each fine drug powder be sufficiently mixed uniformly, honey is added, be made pill to get.
In step (1), the concrete operations of the wine toast processing are as follows: alcohol is added in Xiang Suoshu bulk pharmaceutical chemicals, is successively soaked
Profit, frying after letting cool, obtain wine toast medicinal material.
The mass ratio of the bulk pharmaceutical chemicals and alcohol is 1:0.15-0.25.
The time for carrying out the infiltration is 0.5-2h.
The temperature for carrying out the frying is 100-200 DEG C, and the time for carrying out the frying is 0.5-1.5h.
The preparation method of the paste medicine, includes the following steps:
(1) each raw material component is taken, is sufficiently mixed uniformly, obtains hybrid medicine；
(2) in Xiang Suoshu hybrid medicine plus water is impregnated, after decocted, filtered, obtain decoction liquor；
(3) decoction liquor is subjected to heating concentration to get paste.
In step (2), the mass ratio of hybrid medicine and addition water is 1:2-4, and the time for carrying out the immersion is 1-
3h。
To facilitate the understanding of the present invention, below in the present invention raw material and drug effect be further elaborated.
Radix Salviae Miltiorrhizae, bitter, cold nature.Promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness and restlessness, cool blood to disappear carbuncle.For chest impediment and cardialgia, gastral cavity
Abdomen hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhea menostasis, sore swell and ache curative.
Radix scrophulariae, it is bitter, sweet, salty, it is cold in nature.Clearing heat and cooling blood, detoxicating and resolving a mass, Yin-nourishing and body fluid promoting.It joins the army point for heat, body heat night
Very, blood-head macular eruption, abscess of throat, carbuncle sore tumefacting virus, dry constipation of intestines.
Radix Codonopsis, it is sweet in flavor, it is mild-natured.Tonifying middle-Jiao and Qi, shengjin nourishing.For the deficiency of qi in middle-jiao, anorexia and loose stool, cough and asthma shortness of breath, saliva wound
It is thirsty, blood deficiency chlorosis, palpitation and dizziness.
Radix Notoginseng, sweet in flavor, slight bitter are warm-natured.Dissipating stasis and stanching bleeding, detumescence ding-tong.For spitting blood, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematochezia, metrorrhagia and metrostaxis,
Traumatic hemorrhage, chest and abdomen shouting pain, tumbling and swelling.
Rhizoma Atractylodis Macrocephalae, it is bitter, sweet, it is warm-natured.Air making-up and spleen enlivening, eliminate dampness and have diuretic effect, hidroschesis, miscarriage prevention.For deficiency-weakness of spleen-QI, anorexia and loose stool,
Phlegm retention oedema, exterior deficiency spontaneous perspiration, threatened abortion.
Radix Angelicae Sinensis, it is sweet in flavor, pungent, it is warm-natured.Replenishing and activating blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels.For blood deficiency chlorosis, dizziness palpitaition,
Irregular menstruation, amenorrhea and algomenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dry constipation of intestines.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine promoting blood circulation is logical
Through.For amenorrhea and algomenorrhea, rheumatic arthralgia, injury from falling down.
Radix Astragali, sweet in flavor, slightly warm in nature.Invigorating qi for consolidating superficies, tonifying Qi and lifting yang, promoting pus discharge and tissue regeneration, inducing diuresis for removing edema.For deficiency of vital energy and acking in strength, food
Few loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, from juice night sweat, blood deficiency chlorosis, negative subcutaneous ulcer is unrestrained swollen, deficiency of vital energy and edema, Heat Diabetes.
Poria cocos, it is sweet in flavor, light, it is mild-natured.Clearing damp and promoting diuresis, invigorating the spleen, calming heart.For edema and little urine, phlegm retention anti-dazzle nervous, spleen eating less,
Loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Donkey-hide gelatin, it is sweet in flavor, it is mild-natured.It tonifies the blood and arrest bleeding, nourishing Yin and moistening lung.For blood deficiency chlorosis, dizziness palpitaition, hematemesis and epistaxis, hematochezia
Metrorrhagia and metrostaxis, vexed insomnia, cough caused by dryness lack phlegm.
Colla carapacis et plastri testudinis is put down；It is sweet, salty.Enriching yin is enriched blood, hemostasis.For deficiency of Yin anemia, the hot hectic fever due to yin of labor is spitted blood, bleeding from five sense organs or subcutaneous tissue, dysphoria with smothery sensation
Palpitation with fear, lumbago due to the kidney deficiency, flaccidity of feet and knees, metrorrhagia and metrostaxis, leukorrhagia.
Deer horn glue, it is sweet in flavor, it is salty.Mend lean blood, miscarriage prevention hemostasis.For liver-kidney deficiency, asthenia of essence and blood, consumptive disease wins thin, dizziness
Tinnitus, soreness and weakness of waist and knees, impotence involuntary emission, fertility, threatened abortion, metrorrhagia and metrostaxis leukorrhagia are spitted blood, bleeding from five sense organs or subcutaneous tissue, hemoptysis, hematuria, bruise damage
Wound, negative subcutaneous ulcer sore.
Fructus amomi, acrid flavour are warm-natured.Dampness elimination appetizing, warming spleen and stopping diarrha, regulating the flow of vital energy and preventing miscarriage.For turbi damp obstructing in middle-JIAO, gastral cavity ruffian is not hungry, taste
The cold of insufficiency type, vomiting and diarrhea, hyperemesis gravidarum, threatened abortion.
Hawthorn, sour, sweet, slightly warm in nature.Promoting digestion and removing indigestion, promoting blood circulation to remove blood stasis.For meat stagnation, abdominal pain diarrhoea, the postpartum stasis of blood
Resistance, hernia pain.
Song is built, bitter is warm-natured.Reinforcing spleen to promote digestion, qi-regulating dampness elimination, inducing diaphoresis cure the wound and eat the feeling of stuffiness in chest, abdomen boils vomiting and diarrhoea, dysentery.
Fructus Aurantii, bitter, pungent, sour, cold nature.Regulating the flow of QI to ease the stomach, the stagnant dissipate-swelling of row.For the chest side of body stagnation of the circulation of vital energy, turgor pain, dyspepsia
Do not change, stops in phlegm retention, visceral organ ptosis.
Kuh-seng, bitter are cold in nature.Heat-clearing bath is wet, wind dispelling insecticide, diuresis.For damp-heat in lower-JIAO, leukorrhagia, pruritus vulvae, skin scabies
Itch, scabies, puckery pain of heat gonorrhea.
The coptis, bitter are cold in nature.Heat-clearing and damp-drying drug, purging fire for removing toxin.For damp and hot feeling of fullness, acid regurgitation, dysentery, jaundice, height are vomitted
Hot coma, heart-fire hyperactivity, dysphoria and insomnia, palpitation and uneasiness, blood-head tells nosebleed, hot eyes, toothache are quenched one's thirst, and carbuncle swells treat sore；Eczema is controlled outside,
Wet sore, purulent ear canal.
Mung bean, it is sweet in flavor, it is cool in nature.It is clearing heat and detoxicating, it relieves summer heat, Li Shui.Hot summer weather polydipsia is controlled, oedema rushes down benefit, erysipelas, carbuncle swells, solution
Medicine of a warm nature poison.
Folium isatidis, bitter are cold in nature.It is clearing heat and detoxicating, blood cooling and ecchymoses removing.For pyreticosis hyperpyrexia polydipsia；Coma；Macula；It spits blood；
Bleeding from five sense organs or subcutaneous tissue；Jaundice；Dysentery；Erysipelas；Sore throat；Aphtha；Mumps.
Indigo naturalis, taste is salty, cold in nature.It is clearing heat and detoxicating, blood cooling and ecchymoses removing, clearing liver-fire, arresting convulsion.For febrile virulent maculae, blood-head is spat
Nosebleed, pharyngalgia aphtha, pathogenic fire,toxin and furuncles, pectoralgia of coughing, blood-stained sputum, hot summer weather frightened epilepsy, convulsion.
Olibanum, acrid flavour, hardship are warm-natured.Promoting blood circulation and stopping pain, detumescence and promoting granulation.For dysmenorrhea amenorrhoea, gastral cavity pain, rheumatic arthralgia,
Injuries from falls as well, carbuncle swells sore.
Myrrh, bitter are mild-natured.Promoting blood circulation and stopping pain, detumescence and promoting granulation.For menostasis abdominal pain, gastral cavity pain, injuries from falls as well, carbuncle swells
Sore.
Ox sulphur, bitter are cool in nature.It is clearing heat and detoxicating, relieving convulsion and spasm, dissipating phlegm for resuscitation.It faints for excess heat convulsion, key closes coma, heat toxin
Sore.
Red orpiment, the crystalline solid of realgar possess the medical value similar with realgar in Chinese medicine treatment, have removing toxic substances desinsection,
Removing dampness and eliminating phlegm, the effect of preventing malaria.For treating carbuncle swells furunculosis, snakebite and bugbite, abdominal pain due to enterositosis, frightened epilepsy, malaria.
Iron is fallen, acrid flavour, cool in nature.Checking hyperfunction of the liver and relieving convulsion, removing toxic substances sore is enriched blood.For demented, febrile delirium, palpitation and being susceptible to fright, wind
Arthritis with fixed pain caused by dampness pain, sore swollen toxin, anaemia.
Verdigris, it is sour, puckery, bitter, it is cold in nature.Screen is moved back, rotten sore of dispelling, desinsection spits wind phlegm.For mesh screen, belepharitis ciliaris eye, carbuncle
Subcutaneous ulcer swelling and pain, nasal polyp, sore throat, noma, ulcer on the shank, stubborn dermatitis, anal fistula, wind phlegm stroke.
Spina gleditsiae, acrid flavour are warm-natured.Detumescence and poison retention, apocenosis, desinsection.For ulcer from the beginning of or purulence at not bursting；Scabies are controlled outside
Leprosy.
Lopseed, acrid flavour are warm-natured.Dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, eliminating stasis to subdue swelling, removing toxic substances analgesic.For rheumatic arthralgia, muscle
Bone contracture, the disturbance of lower legs due to pathogenic cold and dampness, lumbar strain, paralysis, amenorrhoea, eczema of scrotum, sore furuncle poison.
Motherwort, bitter, pungent, cold nature.Promoting blood circulation for regulating menstruation, inducing diuresis to remove edema are clearing heat and detoxicating.For irregular menstruation, dysmenorrhea warp
It closes, lochiorrhagia, edema and little urine, sore swollen toxin.
Radix Glycyrrhizae, it is sweet in flavor, it is mild-natured.It invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For taste
Weakness, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, stomach duct and abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong
Property.
The invention has the benefit that
It is of the present invention treatment leukaemia drug, by using Radix Salviae Miltiorrhizae, radix scrophulariae, Radix Codonopsis, Radix Notoginseng, Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis,
Radix Astragali, Poria cocos, donkey-hide gelatin, colla carapacis et plastri testudinis, deer horn glue, fructus amomi, hawthorn, build song, Fructus Aurantii, kuh-seng, the coptis, mung bean, folium isatidis, indigo naturalis,
Olibanum, myrrh, ox sulphur, red orpiment, iron are fallen, verdigris, spina gleditsiae, lopseed, motherwort, totally three Ten Herbs materials are raw material to Radix Glycyrrhizae
And weight proportion appropriate is carried out, with Radix Salviae Miltiorrhizae, radix scrophulariae, Radix Codonopsis, Radix Notoginseng, Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Astragali, Poria cocos, fructus amomi, hawthorn, build
Bent, Fructus Aurantii remolds hemopoietic system；With with cool blood effect kuh-seng, the coptis, mung bean, spina gleditsiae, folium isatidis, indigo naturalis, olibanum,
Myrrh, ox sulphur, red orpiment are dissolved vicious in blood；It is fallen with donkey-hide gelatin, colla carapacis et plastri testudinis, deer horn glue, iron, verdigris, lopseed, motherwort rehabilitation
Physiological tissue and organ return benign cycle；Detoxified with Radix Glycyrrhizae, and coordinating the drug actions of a prescription.By the four aspects mechanism of action, altogether
It is same to play the role for the treatment of leukaemia.This is because present inventor is by the discovery that studies for a long period of time, the cause of disease of leukaemia core
Mechanism is that hemopoietic system is encroached on, and cannot regenerate qualified blood, forms vicious circle so that physiological tissue and organ by
Further infringement forms obstinate disease.It follows that the key for the treatment of leukaemia is remodeling hemopoietic system, dissolves and disliked in blood
Poison, rehabilitation physiological tissue and organ, return benign cycle, are allowed to disease and people is gone to pacify.Data are shown: drug of the present invention is used for
Treat the effective percentage 78% of leukaemia, obvious effective rate 69%, cure rate 63%, good effect of the present invention, cure rate be high, it is low in cost,
Preparation method is simple, has wide application value.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, the described embodiment is only a part of the embodiment of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
1g is represented in following embodiment with 1 parts by weight.
Embodiment 1
The present embodiment provides a kind of pill for treating leukaemia, raw material components include:
24 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of radix scrophulariae, 12 parts by weight of Radix Codonopsis, 4.8 parts by weight of Radix Notoginseng, 12 parts by weight of Rhizoma Atractylodis Macrocephalae, when
Return 8 parts by weight, 12 parts by weight of Radix Astragali, 12 parts by weight of Poria cocos, 4.8 parts by weight of donkey-hide gelatin, 4.8 parts by weight of colla carapacis et plastri testudinis, deer horn glue 4.8
Parts by weight, 12 parts by weight of hawthorn, build bent 8 parts by weight, 8 parts by weight of Fructus Aurantii, 12 parts by weight of kuh-seng, the coptis 8 at 4.8 parts by weight of fructus amomi
Parts by weight, 24 parts by weight of mung bean, 8 parts by weight of folium isatidis, 8 parts by weight of indigo naturalis, 12 parts by weight of olibanum, 12 parts by weight of myrrh, ox sulphur
4.8 parts by weight, 4.8 parts by weight of red orpiment, iron fall 8 parts by weight, 1.6 parts by weight of verdigris, 24 parts by weight of spina gleditsiae, 12 weight of lopseed
Measure part, 24 parts by weight of motherwort, 12 parts by weight of Radix Glycyrrhizae.
Further, the present embodiment provides the preparation method of the pill of the treatment leukaemia, include the following steps:
(1) each bulk pharmaceutical chemicals component is taken, it is as follows to carry out wine toast processing respectively: being added into bulk pharmaceutical chemicals and accounts for 15% matter of bulk pharmaceutical chemicals
The alcohol of amount first carries out infiltration 0.5h, then in 100 DEG C of frying 1.5h, after letting cool, obtains wine toast medicinal material；
(2) step (1) the wine toast medicinal material is subjected to pulverization process, obtains each fine drug powder；
(3) each fine drug powder be sufficiently mixed uniformly, rape flower honey is added, the thin ball of 0.2g/ ball is made, i.e.,
For the pill of the treatment leukaemia.
Embodiment 2
The present embodiment provides a kind of pill for treating leukaemia, raw material components include:
36 parts by weight of Radix Salviae Miltiorrhizae, 18 parts by weight of radix scrophulariae, 18 parts by weight of Radix Codonopsis, 7.2 parts by weight of Radix Notoginseng, 18 parts by weight of Rhizoma Atractylodis Macrocephalae, when
Return 12 parts by weight, 18 parts by weight of Radix Astragali, 18 parts by weight of Poria cocos, 7.2 parts by weight of donkey-hide gelatin, 7.2 parts by weight of colla carapacis et plastri testudinis, deer horn glue 7.2
Parts by weight, 18 parts by weight of hawthorn, build bent 12 parts by weight, 12 parts by weight of Fructus Aurantii, 18 parts by weight of kuh-seng, Huang at 7.2 parts by weight of fructus amomi
Even 12 parts by weight, 36 parts by weight of mung bean, 12 parts by weight of folium isatidis, 12 parts by weight of indigo naturalis, 18 parts by weight of olibanum, 18 weight of myrrh
Part, 7.2 parts by weight of ox sulphur, 7.2 parts by weight of red orpiment, iron fall 12 parts by weight, 2.4 parts by weight of verdigris, 36 parts by weight of spina gleditsiae, thoroughly
Bone grass 18 parts by weight, 36 parts by weight of motherwort, 18 parts by weight of Radix Glycyrrhizae.
Further, the present embodiment provides the preparation method of the pill of the treatment leukaemia, include the following steps:
(1) each bulk pharmaceutical chemicals component is taken, it is as follows to carry out wine toast processing respectively: being added into bulk pharmaceutical chemicals and accounts for 25% matter of bulk pharmaceutical chemicals
The alcohol of amount first carries out infiltration 2h, then in 200 DEG C of frying 0.5h, after letting cool, obtains wine toast medicinal material；
(2) step (1) the wine toast medicinal material is subjected to pulverization process, obtains each fine drug powder；
(3) each fine drug powder be sufficiently mixed uniformly, rape flower honey is added, the thin ball of 0.2g/ ball is made, i.e.,
For the pill of the treatment leukaemia.
Embodiment 3
The present embodiment provides a kind of pill for treating leukaemia, raw material components include:
30 parts by weight of Radix Salviae Miltiorrhizae, 15 parts by weight of radix scrophulariae, 15 parts by weight of Radix Codonopsis, 6 parts by weight of Radix Notoginseng, 15 parts by weight of Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis
10 parts by weight, 15 parts by weight of Radix Astragali, 15 parts by weight of Poria cocos, 6 parts by weight of donkey-hide gelatin, 6 parts by weight of colla carapacis et plastri testudinis, 6 parts by weight of deer horn glue,
6 parts by weight of fructus amomi, 15 parts by weight of hawthorn build bent 10 parts by weight, 10 parts by weight of Fructus Aurantii, 15 parts by weight of kuh-seng, 10 weight of the coptis
Part, 30 parts by weight of mung bean, 10 parts by weight of folium isatidis, 10 parts by weight of indigo naturalis, 15 parts by weight of olibanum, 15 parts by weight of myrrh, ox sulphur 6
Parts by weight, 6 parts by weight of red orpiment, iron fall 10 parts by weight, 2 parts by weight of verdigris, 30 parts by weight of spina gleditsiae, 15 parts by weight of lopseed, benefit
30 parts by weight of Brittle Falsepimpernel Herb, 15 parts by weight of Radix Glycyrrhizae.
Further, the present embodiment provides the preparation method of the pill of the treatment leukaemia, include the following steps:
(1) each bulk pharmaceutical chemicals component is taken, it is as follows to carry out wine toast processing respectively: being added into bulk pharmaceutical chemicals and accounts for 20% matter of bulk pharmaceutical chemicals
The alcohol of amount first carries out infiltration 1.2h, then in 150 DEG C of frying 1h, after letting cool, obtains wine toast medicinal material；
(2) step (1) the wine toast medicinal material is subjected to pulverization process, obtains each fine drug powder；
(3) each fine drug powder be sufficiently mixed uniformly, rape flower honey is added, the thin ball of 0.2g/ ball is made, i.e.,
For the pill of the treatment leukaemia.
The instructions of taking of pill described in embodiment 1-3: adult each 9-12g takes medicine on an empty stomach sooner or later 2 times a day, takes
It is fed again after medicine 60-90min.Children's dosage halves.
Points for attention: 1, can not sexual intercourse during treating.2, medication cannot be interrupted.3, fasting white sugar, green onion, ginger, garlic etc.
The food of the anti-pharmacological property such as maror and white radishes, mung bean.It 4, should not be with other drugs with clothes.
Embodiment 4
The present embodiment provides a kind of paste for treating leukaemia, raw material components include:
24 parts by weight of Radix Salviae Miltiorrhizae, 12 parts by weight of radix scrophulariae, 12 parts by weight of Radix Codonopsis, 4.8 parts by weight of Radix Notoginseng, 12 parts by weight of Rhizoma Atractylodis Macrocephalae, when
Return 8 parts by weight, 12 parts by weight of Radix Astragali, 12 parts by weight of Poria cocos, 4.8 parts by weight of donkey-hide gelatin, 4.8 parts by weight of colla carapacis et plastri testudinis, deer horn glue 4.8
Parts by weight, 12 parts by weight of hawthorn, build bent 8 parts by weight, 8 parts by weight of Fructus Aurantii, 12 parts by weight of kuh-seng, the coptis 8 at 4.8 parts by weight of fructus amomi
Parts by weight, 24 parts by weight of mung bean, 8 parts by weight of folium isatidis, 8 parts by weight of indigo naturalis, 12 parts by weight of olibanum, 12 parts by weight of myrrh, ox sulphur
4.8 parts by weight, 4.8 parts by weight of red orpiment, iron fall 8 parts by weight, 1.6 parts by weight of verdigris, 24 parts by weight of spina gleditsiae, 12 weight of lopseed
Measure part, 24 parts by weight of motherwort, 12 parts by weight of Radix Glycyrrhizae.
Further, the present embodiment provides the preparation method of the paste of the treatment leukaemia, include the following steps:
(1) each raw material component is taken, is sufficiently mixed uniformly, obtains hybrid medicine；
(2) it in Xiang Suoshu hybrid medicine plus 2 times of quality water carry out immersion 3h, is first fried boiling 5min with high fire later, then with small
Fire decocts 90min, and filtering obtains decoction liquor；
(3) decoction liquor is carried out to heating at 40 DEG C and is concentrated into the 2/3 of original volume to get the treatment leukaemia
Paste.
Embodiment 5
The present embodiment provides a kind of paste for treating leukaemia, raw material components include:
36 parts by weight of Radix Salviae Miltiorrhizae, 18 parts by weight of radix scrophulariae, 18 parts by weight of Radix Codonopsis, 7.2 parts by weight of Radix Notoginseng, 18 parts by weight of Rhizoma Atractylodis Macrocephalae, when
Return 12 parts by weight, 18 parts by weight of Radix Astragali, 18 parts by weight of Poria cocos, 7.2 parts by weight of donkey-hide gelatin, 7.2 parts by weight of colla carapacis et plastri testudinis, deer horn glue 7.2
Parts by weight, 18 parts by weight of hawthorn, build bent 12 parts by weight, 12 parts by weight of Fructus Aurantii, 18 parts by weight of kuh-seng, Huang at 7.2 parts by weight of fructus amomi
Even 12 parts by weight, 36 parts by weight of mung bean, 12 parts by weight of folium isatidis, 12 parts by weight of indigo naturalis, 18 parts by weight of olibanum, 18 weight of myrrh
Part, 7.2 parts by weight of ox sulphur, 7.2 parts by weight of red orpiment, iron fall 12 parts by weight, 2.4 parts by weight of verdigris, 36 parts by weight of spina gleditsiae, thoroughly
Bone grass 18 parts by weight, 36 parts by weight of motherwort, 18 parts by weight of Radix Glycyrrhizae.
Further, the present embodiment provides the preparation method of the paste of the treatment leukaemia, include the following steps:
(1) each raw material component is taken, is sufficiently mixed uniformly, obtains hybrid medicine；
(2) it in Xiang Suoshu hybrid medicine plus 4 times of quality water carry out immersion 1h, is first fried boiling 5min with high fire later, then with small
Fire decocts 90min, and filtering obtains decoction liquor；
(3) decoction liquor is carried out to heating at 50 DEG C and is concentrated into the 2/3 of original volume to get the treatment leukaemia
Paste.
Embodiment 6
The present embodiment provides a kind of paste for treating leukaemia, raw material components include:
30 parts by weight of Radix Salviae Miltiorrhizae, 15 parts by weight of radix scrophulariae, 15 parts by weight of Radix Codonopsis, 6 parts by weight of Radix Notoginseng, 15 parts by weight of Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis
10 parts by weight, 15 parts by weight of Radix Astragali, 15 parts by weight of Poria cocos, 6 parts by weight of donkey-hide gelatin, 6 parts by weight of colla carapacis et plastri testudinis, 6 parts by weight of deer horn glue,
6 parts by weight of fructus amomi, 15 parts by weight of hawthorn build bent 10 parts by weight, 10 parts by weight of Fructus Aurantii, 15 parts by weight of kuh-seng, 10 weight of the coptis
Part, 30 parts by weight of mung bean, 10 parts by weight of folium isatidis, 10 parts by weight of indigo naturalis, 15 parts by weight of olibanum, 15 parts by weight of myrrh, ox sulphur 6
Parts by weight, 6 parts by weight of red orpiment, iron fall 10 parts by weight, 2 parts by weight of verdigris, 30 parts by weight of spina gleditsiae, 15 parts by weight of lopseed, benefit
30 parts by weight of Brittle Falsepimpernel Herb, 15 parts by weight of Radix Glycyrrhizae.
Further, the present embodiment provides the preparation method of the paste of the treatment leukaemia, include the following steps:
(1) each raw material component is taken, is sufficiently mixed uniformly, obtains hybrid medicine；
(2) it in Xiang Suoshu hybrid medicine plus 3 times of quality water carry out immersion 2h, is first fried boiling 5min with high fire later, then with small
Fire decocts 90min, and filtering obtains decoction liquor；
(3) decoction liquor is carried out to heating at 45 DEG C and is concentrated into the 2/3 of original volume to get the treatment leukaemia
Paste.
The instructions of taking of paste medicine described in embodiment 4-6: 2 times a day, each 120-150ml, the morning and evening is on an empty stomach by adult
Medication, medication are fed again after 60-90 minutes.Children's dosage halves.
Points for attention: 1, can not sexual intercourse during treating.2, medication cannot be interrupted.3, fasting white sugar, green onion, ginger, garlic etc.
The food of the anti-pharmacological property such as maror and white radishes, mung bean.It 4, should not be with other drugs with clothes.
Experimental example
The present inventor is by taking the observation of drug of the present invention to clinical 702 leukaemics, wherein effectively
547 people, effectively in effective 484 people, effective middle 442 people of clinical cure.
Application method: it is taken according to the above-mentioned instructions of taking of pill or paste.
Efficacy assessment standard:
It is effective: compare the treatment condition before treating or carried out early period, feels symptom and alleviated, matter of surviving
Amount makes moderate progress.
Effective: more similar patient, clinical manifestation pathology period are elongated, and life quality is obviously improved, and life extends 1 year
More than.
Clinical cure: various kinds physical examination index is normal, and life cycle 5 years or more.
It is specific as shown in table 1.
The therapeutic effect of table 1- drug of the present invention counts
| Therapeutic effect | Effectively | It is effective | Clinical cure |
| Number | 547 | 484 | 442 |
| Percentage | 78% | 69% | 63% |
As it can be seen from table 1 drug of the present invention is used to treat the effective percentage 78% of leukaemia, obvious effective rate 69% is controlled
More rate 63%, good effect, cure rate are high.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, appoints
What those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, answer
It is included within the scope of the present invention.Therefore, protection scope of the present invention should be with the scope of protection of the claims
It is quasi-.
Claims (10)
1. a kind of drug for treating leukaemia, which is characterized in that raw material components include:
Radix Salviae Miltiorrhizae 24-36 parts by weight, radix scrophulariae 12-18 parts by weight, Radix Codonopsis 12-18 parts by weight, Radix Notoginseng 4.8-7.2 parts by weight, Rhizoma Atractylodis Macrocephalae 12-
18 parts by weight, Radix Angelicae Sinensis 8-12 parts by weight, Radix Astragali 12-18 parts by weight, Poria cocos 12-18 parts by weight, donkey-hide gelatin 4.8-7.2 parts by weight, tortoise
First glue 4.8-7.2 parts by weight, fructus amomi 4.8-7.2 parts by weight, hawthorn 12-18 parts by weight, build song at deer horn glue 4.8-7.2 parts by weight
8-12 parts by weight, Fructus Aurantii 8-12 parts by weight, kuh-seng 12-18 parts by weight, coptis 8-12 parts by weight, mung bean 24-36 parts by weight, smalt
Leaf 8-12 parts by weight, indigo naturalis 8-12 parts by weight, olibanum 12-18 parts by weight, myrrh 12-18 parts by weight, ox sulphur 4.8-7.2 weight
Part, red orpiment 4.8-7.2 parts by weight, iron fall 8-12 parts by weight, verdigris 1.6-2.4 parts by weight, spina gleditsiae 24-36 parts by weight, deep
Careless 12-18 parts by weight, motherwort 24-36 parts by weight, Radix Glycyrrhizae 12-18 parts by weight.
2. the drug for the treatment of leukaemia according to claim 1, which is characterized in that raw material components include:
30 parts by weight of Radix Salviae Miltiorrhizae, 15 parts by weight of radix scrophulariae, 15 parts by weight of Radix Codonopsis, 6 parts by weight of Radix Notoginseng, 15 parts by weight of Rhizoma Atractylodis Macrocephalae, 10 weight of Radix Angelicae Sinensis
Measure part, 15 parts by weight of Radix Astragali, 15 parts by weight of Poria cocos, 6 parts by weight of donkey-hide gelatin, 6 parts by weight of colla carapacis et plastri testudinis, 6 parts by weight of deer horn glue, fructus amomi 6
Parts by weight, 15 parts by weight of hawthorn build bent 10 parts by weight, 10 parts by weight of Fructus Aurantii, 15 parts by weight of kuh-seng, 10 parts by weight of the coptis, mung bean
30 parts by weight, 10 parts by weight of folium isatidis, 10 parts by weight of indigo naturalis, 15 parts by weight of olibanum, 15 parts by weight of myrrh, 6 parts by weight of ox sulphur, hero
Smart 6 parts by weight, iron fall 10 parts by weight, 2 parts by weight of verdigris, 30 parts by weight of spina gleditsiae, 15 parts by weight of lopseed, 30 weight of motherwort
Part, 15 parts by weight of Radix Glycyrrhizae.
3. the drug for the treatment of leukaemia according to claim 1, which is characterized in that the drug is pill or paste.
4. the preparation method of pill medicine as claimed in claim 3, which comprises the steps of:
(1) each bulk pharmaceutical chemicals component is taken, wine toast processing is carried out, obtains wine toast medicinal material；
(2) step (1) the wine toast medicinal material is subjected to pulverization process, obtains each fine drug powder；
(3) each fine drug powder be sufficiently mixed uniformly, honey is added, be made pill to get.
5. the preparation method of pill medicine according to claim 4, which is characterized in that in step (1), the wine toast processing
Concrete operations are as follows: alcohol is added in Xiang Suoshu bulk pharmaceutical chemicals, successively infiltrated, frying, let cool after, obtain wine toast medicinal material.
6. the preparation method of pill medicine according to claim 5, which is characterized in that the quality of the bulk pharmaceutical chemicals and alcohol
The ratio between be 1:0.15-0.25.
7. the preparation method of pill medicine according to claim 5, which is characterized in that the time for carrying out the infiltration is
0.5-2h。
8. the preparation method of pill medicine according to claim 5, which is characterized in that the temperature for carrying out the frying is
100-200 DEG C, the time for carrying out the frying is 0.5-1.5h.
9. the preparation method of paste medicine according to claim 3, which comprises the steps of:
(1) each raw material component is taken, is sufficiently mixed uniformly, obtains hybrid medicine；
(2) in Xiang Suoshu hybrid medicine plus water is impregnated, after decocted, filtered, obtain decoction liquor；
(3) decoction liquor is subjected to heating concentration to get paste.
10. preparation method according to claim 9, which is characterized in that in step (2), the matter of hybrid medicine and addition water
The ratio between amount is 1:2-4, and the time for carrying out the immersion is 1-3h.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1157166A (en) * | 1996-01-25 | 1997-08-20 | 温顺明 | Xuefukang medicine |
| CN1493327A (en) * | 2003-09-28 | 2004-05-05 | 李维庆 | Chinese medicine for treating leucocythemia and its preparation method and application. |
-
2018
- 2018-12-18 CN CN201811552169.2A patent/CN109589389A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1157166A (en) * | 1996-01-25 | 1997-08-20 | 温顺明 | Xuefukang medicine |
| CN1493327A (en) * | 2003-09-28 | 2004-05-05 | 李维庆 | Chinese medicine for treating leucocythemia and its preparation method and application. |
Non-Patent Citations (3)
| Title |
|---|
| 杨松年 等: ""药用矿物的地质产状、性质、研究与展望"", 《地质与勘探》 * |
| 梁立新等: "益血生胶囊治疗急性白血病化疗后全血细胞减少症45例", 《辽宁中医杂志》 * |
| 郑丹丹等: "中医药治疗急性白血病的研究进展", 《医学综述》 * |
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