CN109589273A - Low irritant body cleanser composition - Google Patents
Low irritant body cleanser composition Download PDFInfo
- Publication number
- CN109589273A CN109589273A CN201710913723.4A CN201710913723A CN109589273A CN 109589273 A CN109589273 A CN 109589273A CN 201710913723 A CN201710913723 A CN 201710913723A CN 109589273 A CN109589273 A CN 109589273A
- Authority
- CN
- China
- Prior art keywords
- composition
- weight
- surfactant
- skin cleanser
- low irritant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
Abstract
The present invention relates to a kind of body cleanser compositions of low irritant, more specifically, it is related to a kind of including more than any one in the group being made of glutamate family anionic surfactant, both sexes phosphate-gallate series amphoteric surfactant and nonionic surfactant low irritant composition of skin cleanser.Composition of skin cleanser of the invention is excellent to the obvious low and foaming power of the stimulation degree of skin and eyes, by being thickened using water-soluble thickener, to equably keep the character of content, thus also have the effect of that dosage form stability is excellent under high temperature and low temperature.
Description
Technical field
The present invention relates to one kind can be suitable for sensitive and fragile infant's skin, stimulation minimum, and
And composition of skin cleanser (the Low irritant of the excellent in stability of foaming power and the content of different temperatures
personal cleansing composition having improved capacity for forming foam and
stability)。
Background technique
In order to remove the dust being adhered on skin or hair or pollution, synthetic surfactant such as anion, both sexes
Ion, nonionic or cationic surfactant are for various cleaning compositions such as shower cream, facial cleanser or shampoos.Not only such as
This, synthetic surfactant is extensive for the purpose of the cleaning for removing sebum caused by the skins such as scalp, face or body
Using.In addition, blistering and foaming stability for the more amount of cleaning compositions, need using sufficient surface-active
The cooperation and level of agent.
But as well known to the correlative technology field, synthetic surfactant has the tendency of stimulation skin and eyes.This
Outside, in the case where increasing the concentration of synthetic surfactant to clean and blister, have increase skin is tight, itch or
Pachylosis etc. is to the stimulation of skin and the tendency of Eye irritation.Requiring milder skin low irritant always as a result,
Composition of skin cleanser.
For the cleaning compositions of milder low irritant, at KR published patent the 10-2006-0093211st
It discloses by the sulfuric acid series anion surfactant of alkyl ethoxylated, or in sodium isethionate
(isethionate), sulfosuccinic acid (sulfosuccinate), acyl group sodium sulfonate (acyl taurate), acyl glutamic acid
Surfactants such as (acyl glutamate) are individually or mixed ingredient, or sour in glycine betaine (Betaine) and both sexes
The amphoteric surfactant of salt system (Amphoacetate series), or in alkyl polyglycoside
(alkylpolyglycoside), the nonionic surfactant of fatty acid alkanol amides etc., or in mixed ingredient, packet
Containing having the additive for alleviating effect of stimulation, so as to be relieved the liquid cleanser composition of skin irritatin.But institute
State the sulfuric acid series anion that liquid cleanser composition is the alkyl ethoxylated containing the stimulation for being known as having relatively strong
The composition of surfactant, therefore, stimulation remission effect are not obvious.
In addition, KR published patent the 10-2013-0088836th discloses and is included in by unethoxylated anion table
The surfactant selected in the group of face activating agent and at least one amphoteric surfactant composition, and by utilizing low molecule
Noncrosslinking acrylic copolymer is measured, there is relatively high transparency, generate relatively more bubble and low stimulation characteristic
Polymer.But the composition is containing irritating relatively strong alkylsurfuric acid series anion surfactant, also, in order to subtract
Pinprick, with the content for reducing surfactant, viscosity reduction, thus proper viscosity and utilization synthesis when in order to use
Polymer, therefore the effect for alleviating stimulation is not obvious.
Existing technical literature
Patent document
(patent document 0001) KR published patent the 10-2006-0093211st
(patent document 0002) KR published patent the 10-2013-0088836th
Summary of the invention
Therefore, the problem to be solved by the present invention is to provide a kind of without irritating relatively large sulfuric acid system surface-active
Agent, also, in the case where stimulating small and weakly acidic pH, the glutamate family anionic surfactant containing excellent in stability, both sexes
The composition of phosphate-gallate series amphoteric surfactant and nonionic surfactant.
In addition, the problem to be solved by the present invention is to provide a kind of additionally natural including being originated from the composition
Water-soluble thickener and keep usability excellent, and the weakly acidic low stimulation of foaming power and the excellent in stability of different temperatures
Composition of skin cleanser.
The present invention provides one kind and is included in by glutamate family anionic surfactant, both sexes phosphate-gallate series amophoteric surface active
The human body low irritant skin of more than one surfactants selected in the group of agent and nonionic surfactant composition is clear
Clean dose of composition.
The present inventor is in order to overcome the problem of the prior art, although being easy blistering and thickening to develop,
Sulfuric acid series anion surfactant without serious stimulation skin, foaming power and thickening degree are excellent and stimulate obvious low skin
Cleanser compositions have carried out making great efforts research.Finally, it is found that be included in by stimulate it is small and the weakly acidic pH under the conditions of it is steady
Qualitative excellent glutamate family anionic surfactant, both sexes phosphate-gallate series amphoteric surfactant and non-ionic surface active
The surfactant selected in the group of agent composition, also, the content of the total surfactant of composition of skin cleanser is subtracted
As low as 14% hereinafter, irritation is substantially reduced and foaming power is excellent so as to make.In addition, in the composition by being originated from day
Right water-soluble thickener is come in the case where thickening, it was found that even if the character of content is uniform under high temperature and low temperature
Ground is kept, and discovery stability is enhanced, so as to complete the present invention.
Hereinafter, each ingredient for constituting composition of skin cleanser of the invention is described in more details.
In the surfactant that the present invention uses, it may include by glutamate family anionic surfactant, both sexes second
Surface-active more than any one selected in the group of sour sodium amphoteric surfactant and nonionic surfactant composition
Agent.Preferably, composition of skin cleanser of the invention may include whole glutamate family anionic surfactants, both sexes hydrochlorate
It is amphoteric surfactant and nonionic surfactant.Composition of skin cleanser of the invention does not preferably include skin
The serious sulfuric acid system surfactant of skin irritation.
In the case where glutamate family anionic surfactant is used only in the composition, although foaming power is excellent,
There is the phenomenon that being precipitated at low temperature, and there is limitation on making stimulation alleviation.In addition, both sexes phosphate-gallate series two are used only
Property surfactant in the case where, make foaming power and stimulation alleviate on exist limitation.In addition, living non-ionic surface is used only
Property agent in the case where, although stimulation remission effect and excellent in stability at low temperature, foaming power is substantially reduced.Therefore, exist
The composition preferably include whole glutamate family anionic surfactants, both sexes sodium acetate amphoteric surfactant and
In the case where nonionic surfactant, foaming power is excellent, and skin irritatin is obviously reduced, also, the character with different temperatures
The effect of excellent in stability.
It include the glutamate family anionic surfactant, both sexes sodium acetate both sexes in the composition of skin cleanser
In the case where surfactant and nonionic surfactant, the weight ratio of each surfactant is 2~6:2~8:1~4
(glutamate family anionic surfactant: both sexes phosphate-gallate series amphoteric surfactant: nonionic surfactant).In the present invention
Composition of skin cleanser include weight ratio as described above the combination of surfactant in the case where, skin or Eye irritation
Degree reduces, and foaming power is excellent and the dosage form stability of different temperatures is obviously excellent.
In the present invention, the glutamate family anionic surfactant may include selected from by two hexanoyl glutamic acid
It is (Disodium Caproyl Glutamate), lauroyl glutamate disodium (Disodium lauroyl glutamate), hard
Acyl sodium glutamate (Disodium stearoyl glutamate), cocounut oil acyl disodium glutamate (Disodium cocoyl
Glutamate), sodium lauroyl glutamate (Sodium lauroyl glutamate), myristoyl glutamate sodium (Sodium
Myristoyl glutamate), phthalyl glutamic acid sodium (Sodium palmoyl glutamate), stearoyl paddy ammonia
Sour sodium (Sodium stearoyl glutamate), olive oleoyl sodium glutamate (Sodium olivoyl Glutamate), coconut palm
Oleoyl sodium glutamate (Sodium cocoyl glutamate), ferrous acid lauroyl glutamate (TEA-Lauroyl
Glutamate), iron mucoprotein glutamic acid (TEA-Cocoyl glutamate), lauroyl glutamate potassium (Potassium
Lauroyl glutamate), myristoyl glutamate potassium (Potassium myristoyl glutamate) and cocounut oil acyl
More than any one in the groups of compositions such as potassium glutamate (Potassium cocoyl glutamate), but it is not limited to this.
The glutamate family anionic surfactant is preferably used alone or is used in conjunction with two or more.The glutamate family
Anionic surfactant preferably uses sodium cocoyl glutamate.
In the present invention, the content of the glutamate family anionic surfactant may include using composition total weight as base
Standard accounts for 0.1 weight % to 10 weight %, preferably comprises from 1 weight % to 8 weight %, more preferably accounts for 2 weight % to 6 weights
Measure %.The content of the glutamate family surfactant is benchmark accounting less than 0.1 weight using composition of skin cleanser total weight
In the case where measuring %, foaming power and cleaning force can be reduced；In the case where greater than 10 weight %, has and content is precipitated at low temperature
And the tendency for reducing stability.
In the present invention, the both sexes phosphate-gallate series amphoteric surfactant may include selected from by lauryl both sexes sodium acetate
(Sodium lauroamphoacetate), cocoyl both sexes sodium acetate (Sodium coco amphoacetate), mango two
Property sodium acetate (Sodium mango amphoacetate), missible oil wood both sexes sodium acetate (Sodium shea butter
Amphoacetate), dessert almond both sexes sodium acetate (Sodium olive amphoacetate), olivine sodium sodium diacelate
(Sodium Sweet Almond amphoacetate), cupu oil both sexes sodium acetate (Sodium cocoa Butter
Amphoacetate), cottonseed both sexes sodium acetate (Sodium Cotton Seed amphoacetate), Morocco's nut both sexes
Sodium acetate (Sodium argan amphoacetate), lauroyl both sexes base diethyl acid disodium (Disodium
Lauroamphodiacetate), cocoyl both sexes acetic acid disodium (Disodium cocoamphoacetate) and cocounut oil acyl
One or more of groups of compositions such as both sexes base diethyl acid disodium (Disodium cocoamphodiacetate), but
It is not limited to this.The both sexes acetate amphoteric surfactant is preferably used alone or is used in conjunction with two or more.
The both sexes phosphate-gallate series amphoteric surfactant preferably uses cocoyl both sexes acetic acid disodium.
In the present invention, the content of the both sexes acetate amphoteric surfactant may include using composition total weight as base
Standard accounts for 0.1 weight % to 12 weight %, preferably comprises from 1 weight % to 10 weight %, more preferably accounts for 2 weight % to 8 weights
Measure %.The content of the both sexes acetate amphoteric surfactant is less than by benchmark accounting of composition of skin cleanser total weight
In the case where 0.1 weight %, the effect that stimulation is alleviated is not exhibited；In the case where greater than 12 weight %, have use feeling smooth
And the disadvantage for causing scavenging period long.
In the present invention, the nonionic surfactant may include alkyl polyglycoside system (Alkylpolyglucoside
Series), fatty acid alkanol amides system (Fatty acid alkanolamide series) or oxidation amine system surface-active
Agent etc. is then not particularly limited if can be used for the surfactant of common composition of skin cleanser.For example, institute
Stating alkyl polyglycoside system surfactant may include caprylyl glucosides (Caprylyl glucoside), caprylic/capric glucose
Glycosides (Caprylyl/capric glucoside), decyl glucoside (Decyl glucoside), lauryl glucoside
(Lauryl glucoside), myristyl glucoside (Myristyl glucoside), cetyl glucoside
(Cetearyl glucoside), cocoa glucoside (Coco-glucoside) or palm kernel/cocoa glucoside (Palm
Kernel/coco-glucoside) etc.；Fatty acid alkanol amides system surfactant may include lauramide MEA, coconut
Amide MEA, coconut oleoyl amine methyl MEA or coconut oleoyl amine DEA etc.；The oxidation amine system surfactant may include lauramide
Propyl amine oxide, cocamidopropyl propyl amide amine oxide, oleic acid amine (Korean are as follows:) or soybean acyl ammonia
Base propyl amine oxide (Korean are as follows:) etc..The non-ionic surface active
Agent preferably uses cocoa glucoside or coconut oleoyl amine methyl MEA.
In the present invention, the content of the nonionic surfactant may include that 0.01 is accounted on the basis of composition total weight
Weight % to 8 weight % preferably comprises from 0.1 weight % to 6 weight %, more preferably accounts for 1 weight % to 4 weight %.It is described
The content of nonionic surfactant using composition of skin cleanser total weight as benchmark accounting less than 0.01 weight % the case where
Under, do not exhibit the effect that stimulation is alleviated and the not effect of low-temperature stability；In the case where greater than 8 weight %, has and use
The disadvantage felt smooth and cause scavenging period long.
In the present invention, the content of the total surfactant of the composition of skin cleanser refers in the composition
The total weight percent for all surfaces activating agent that can contain.The total surfactant content of the composition of skin cleanser
It may include accounting for 2 weight % to 14 weight % on the basis of composition total weight, preferably comprise from 4 weight % to 12 weight %, more
6 weight % are preferably comprised to 10 weight %.The content of the total surfactant is using composition of skin cleanser total weight as base
In the case that quasi- accounting is less than 2 weight %, foaming power can reduce and be not easy to dosage form as natural water-soluble thickener is originated from
It stabilizes；In the case where 14 weight %, it is possible to increase stimulation.
In the present invention, the composition additionally includes water-soluble thickener, so as to be mentioned by thickening effect
High dosage form stability.The water-soluble thickener preferably using be originated from natural goods water-soluble thickener, such as selected from by
Xanthan gum, carragheen, locust bean gum, guar gum, tara gum, tamarind gum, Arabic gum, bassora gum, gum acacia, pectin
And more than any one in the group of the compositions such as agar, but it is not limited to this.The water-soluble thickener can be by preferably
It is used alone or uses with and two or more obtain desired thickening effect.
In the present invention, the content of the water-soluble thickener may include that 0.001 weight is accounted on the basis of composition total weight
% to 3 weight % is measured, 0.01 weight % to 2 weight % is preferably comprised from, more preferably accounts for 0.1 weight % to 1 weight %.It is described
The content of water-soluble thickener using composition of skin cleanser total weight as benchmark accounting less than 0.001 weight % in the case where,
Thickening effect is not exhibited；In the case where greater than 3 weight %, have causes mobility to reduce because viscosity is very high, to make
The problem of dissolubility reduces.
For composition of skin cleanser, as sensitive and infant in use, patch test is as reply
The method of the used test skin irritatin of the case where into eyes and the most widely applied.Although the method can be
Sample is directly applied to human body and observes the reaction on actual skin, so as to become the most clear of cutaneous safety
Method still for evaluating a large amount of sample, have difficulties, and when evaluating Eye irritation, there is limit
System.In addition, limit may be present when the irritation of skin and eyes to people is reacted in vitro test (in-vitro) method
System can carry out the HET-CAM test for being known as eye conjunctiva substitution test, thereby confirm that stimulation to overcome the limitation of reality
Property obvious low raw material and composition.
For composition of skin cleanser, on keeping the stability in visual aesthetical perception and dosage form, quilt
Dosage form turn to do not lead to the problem of precipitation with mutually separate it is critically important.It is low especially for the content of surfactant and including low stimulation
For the composition of property surfactant, using water-soluble thickener come when thickening, to the composition of different temperatures through when it is steady
It is qualitative to have an impact, therefore, when using water-soluble thickener to thicken, keep phase stability extremely important.
Composition of skin cleanser of the invention has the feature that not only at high temperature, but also does not also analyse at low temperature
It other materials and does not generate out and mutually separates and show fixed character.In the present invention, the high temperature can be 50 DEG C, and low temperature can
To be 0 DEG C.
In particular, confirmed in a specific embodiment of the invention, under low temperature and high temperature, by skin of the invention
Cleanser compositions take care of 4 weeks, do not generate yet precipitation phenomenon with mutually separate and be able to maintain transparent dosage form.
In addition, common composition of skin cleanser is in the case that viscosity is too small and dilute, due to mobility when in use
By force, loss amount is big, therefore there is inconvenience in use and economically；In the case that viscosity is excessive, use feeling is bad and because unhappy
Speed generates foam and there is inconvenience.But composition of skin cleanser of the invention as composition of skin cleanser have it is excellent
Different viscosity, to have the feature for improving ease of use.The viscosity of composition of skin cleanser of the invention, which refers to, utilizes 3
Axis (Spindle), Brookfield (Brookfield) viscosimeter, at 25 DEG C, with the sample of 12rpm measurement 60 seconds
Viscosity is come the viscosity that measures.Composition of skin cleanser of the invention can have the viscosity greater than 10ps, it is therefore preferred to have 10 to
The viscosity of 40ps more preferably has 10 to 30ps viscosity.The present inventor is by composition of skin cleanser with institute
Range of viscosities is stated come in the case where manufacturing, by testing come to having convenience when using to confirm, to confirmed energy
It is enough as the excellent composition of skin cleanser of usability come using.
Composition of skin cleanser of the invention, can in order to keep the basic physical property and quality as cleanser compositions
Additionally include can be usually used effectively in cleanser compositions selected from by amphoteric surfactant, moisturizer, pigment,
In the group of the compositions such as chelating agent, antioxidant, fungicide, preservative, pH adjusting agent, fragrance and dyestuff any one with
On.
In addition, composition of skin cleanser of the invention is applicable to a variety of doses of liquid, lotion, paste or gel etc.
Type, also, form is used as it, it can be used for scalp detergent, eyewash, shower cream, hand cleanser, shampoo, facial cleanser, liquid
Body cleaning material or balneation agent etc., but it is not limited to this.
On the basis of composition total weight, present invention preferably includes: glutamate family anionic surfactant accounts for 0.1 weight
Measure % to 10 weight %；Both sexes phosphate-gallate series amphoteric surfactant accounts for 0.1 weight % to 12 weight %；Nonionic surfactant
0.01 weight % is accounted for 8 weight %；And water-soluble thickener accounts for 0.001 to weight %, and provides the surfactant
Total content the low irritant composition of skin cleanser of 2 to 14 weight % is accounted on the basis of composition total weight.It is described to include
The combined composition of skin cleanser of certain content ingredient is obviously low to the stimulation degree of skin and eyes, and foaming power is excellent, and
And dosage form stability is also most excellent under high temperature and low temperature.
In addition, the present invention includes selected from by glutamate family anionic surfactant, both sexes phosphate-gallate series amophoteric surface active
More than any one in the group of agent and nonionic surfactant composition surfactant and water-soluble thickener, and
The total content for providing the surfactant accounts for the low irritant skin cleaning of 2 to 14 weight % on the basis of composition total weight
The manufacturing method of agent composition.The content of the ingredient added in the manufacturing method can in the composition of skin cleanser
Explanation in the content recorded add identical content.
Invention effect
Composition of skin cleanser of the invention is obviously low to the stimulation degree of skin and eyes, and foaming power is excellent, and benefit
It is thickened with water-soluble thickener, to keep the character of content uniform, thus having also has under high temperature and low temperature
The effect of excellent dosage form stability.
Specific embodiment
Hereinafter, will enumerate embodiment etc. in order to help understanding of the invention and be described in detail.But reality of the invention
Applying example can be deformed into various other forms, and the scope of the present invention can not be defined to following embodiments and explain.The present invention
Embodiment be in order to more fully illustrate to those skilled in the art the present invention and provide.
The manufacture of Production Example and embodiment
Using raw material shown in following table 1, Production Example 1-10 is manufactured respectively, is surveyed to implement eye conjunctiva stimulation
It tries (HET-CAM test).
[table 1]
Composition of skin cleanser has been manufactured according to each composition (unit: weight %) of following table 2 to 3.To following table 2 with
And 3 record embodiment and comparative example composition, irritation is had rated by HET-CAM test；Foaming power is with 5 points
Standard, foam number when using is investigated by quality evaluation.Estimation of stability is the high temperature 50 at 0 DEG C of low temperature
At DEG C, whether keeping 1 month simultaneously observes and is precipitated and mutually separates.Viscosity is to utilize 3 axis (Spindle), Brookfield
(Brookfield) viscosimeter determines the viscosity of 60 seconds samples with 12rpm at 25 DEG C.
[table 2]
[table 3]
Experimental example
(1) eye conjunctiva stimulation test (HET-CAM)
Raw material with 5% concentration, implemented in stoste reaction time method by composition of skin cleanser, as described in Table 4,
Divided into for 4 stages, result is as described in Table 5.
[table 4]
| [Q]Score | It stimulates very weak | It stimulates weak | It is irritating | Stimulation is strong |
| ≤ 0.8 (following) | ○ | |||
| 0.8<Q<1.2 | ○ | |||
| 1.2≤Q < 2.0 | ○ | |||
| 2.0≤(more than) | ○ |
2) foaming power is evaluated
Of the foaming power with 5 minute marks standard, by quality evaluation come the composition to embodiment and comparative example when in use
Bubble amount is investigated, and result is as shown in following table 5-7.
(3) estimation of stability
Whether estimation of stability is after keeping 1 month, to observe at 0 DEG C of low temperature, 50 DEG C of high temperature and be precipitated and mutually separate,
Its result is shown in table 6 and table 7.If not changing compared with when manufacture, then it represents that be O；If having subtle suspension, table
It is shown as △；If precipitating or precipitate are arrived in cognition, then it represents that be X.
(4) viscosity
According to each composition (unit: weight %) of the table 2 and table 3, under normal (room temperature), from plastic containers
The viscosity results of composition of skin cleanser are arrived.Viscosity is to utilize 3 axis (Spindle), Brookfield
(Brookfield) viscosimeter determines the viscosity of 60 seconds samples with 12rpm, result is in table 6 and table 7 at 25 DEG C
In show, indicate in the following manner.
10-40ps: suitably in use
Greater than 40ps: in use, viscosity is high
Less than 10ps: in use, viscosity is dilute
[table 5]
[table 6]
[table 7]
As shown in the table 5, in eye conjunctiva stimulation test, sulfuric acid series anion surfactant and glycine betaine system/sulphur
Base glycine betaine system amphoteric surfactant (Korean are as follows: ) stimulation
It is be evaluated as very high.
As shown in the table 6 and table 7, compared with comparative example 1 to 11, it can be seen that its eye conjunctiva stimulates test result, this
It is obvious low that the composition of skin cleanser (embodiment 1 to 9) of invention is be evaluated as stimulation, and foaming power is also excellent.In addition, low
Under warm (0 DEG C) and high temperature (50 DEG C), the character of content is also without being precipitated or mutually separating and fixedly kept, thus really
Dosage form stability of accepting is excellent.
Claims (13)
1. a kind of low irritant composition of skin cleanser, wherein including selected from by glutamate family anionic surfactant, two
Property phosphate-gallate series amphoteric surfactant and nonionic surfactant composition group in any one more than.
2. low irritant composition of skin cleanser according to claim 1, which is characterized in that
The composition includes glutamate family anionic surfactant, both sexes phosphate-gallate series amphoteric surfactant and nonionic
Surfactant.
3. low irritant composition of skin cleanser according to claim 1, which is characterized in that
In the composition, the total content of surfactant accounts for 2 weight % to 14 weight % on the basis of composition total weight.
4. low irritant composition of skin cleanser according to claim 2, which is characterized in that
The glutamate family anionic surfactant, both sexes phosphate-gallate series amphoteric surfactant and nonionic surfactant
Weight ratio be 2-6:2-8:1-4.
5. low irritant composition of skin cleanser according to claim 1, which is characterized in that
The glutamate family anionic surfactant accounts for 0.1 weight % to 10 weight % on the basis of composition total weight.
6. low irritant composition of skin cleanser according to claim 1, which is characterized in that
The both sexes phosphate-gallate series amphoteric surfactant accounts for 0.1 weight % to 12 weight % on the basis of composition total weight.
7. low irritant composition of skin cleanser according to claim 1, which is characterized in that
The nonionic surfactant accounts for 0.01 weight % to 8 weight % on the basis of composition total weight.
8. low irritant composition of skin cleanser according to claim 1, which is characterized in that
The composition further includes water-soluble thickener.
9. low irritant composition of skin cleanser according to claim 8, which is characterized in that
The composition includes the water-soluble thickener that 0.001 weight % to 3 weight % is accounted on the basis of composition total weight.
10. low irritant composition of skin cleanser according to claim 1, which is characterized in that
The viscosity of the composition is 10ps to 40ps.
11. low irritant composition of skin cleanser according to claim 1, which is characterized in that
The composition does not include sulfuric acid system surfactant.
12. a kind of low irritant composition of skin cleanser, wherein
On the basis of composition total weight, comprising:
Glutamate family anionic surfactant accounts for 0.1 weight % to 10 weight %；Both sexes phosphate-gallate series amphoteric surfactant accounts for
0.1 weight % to 12 weight %；Nonionic surfactant accounts for 0.01 weight % to 8 weight %；And water-soluble thickener accounts for
0.001 weight % to 3 weight %,
The total content of the surfactant accounts for 2 weight % to 14 weight % on the basis of composition total weight.
13. a kind of manufacturing method of low irritant composition of skin cleanser, wherein include:
Selected from by glutamate family anionic surfactant, both sexes phosphate-gallate series amphoteric surfactant and non-ionic surface active
More than any one in the group of agent composition surfactant and water-soluble thickener,
The total content of the surfactant accounts for 2 weight % to 14 weight % on the basis of composition total weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710913723.4A CN109589273A (en) | 2017-09-30 | 2017-09-30 | Low irritant body cleanser composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710913723.4A CN109589273A (en) | 2017-09-30 | 2017-09-30 | Low irritant body cleanser composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109589273A true CN109589273A (en) | 2019-04-09 |
Family
ID=65955577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710913723.4A Pending CN109589273A (en) | 2017-09-30 | 2017-09-30 | Low irritant body cleanser composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109589273A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1228804A (en) * | 1996-07-03 | 1999-09-15 | 普罗克特和甘保尔公司 | Cleansing compositions |
| CN1449735A (en) * | 2002-03-28 | 2003-10-22 | 莱雅公司 | Foam cosmetic composition for cleaning or dress taking off |
| US20110139170A1 (en) * | 2008-08-18 | 2011-06-16 | Thomas Hippe | Non-sulfate mild surfactant system for skin and hair cleaning |
| CN102958568A (en) * | 2010-06-24 | 2013-03-06 | 强生消费者公司 | Low-irritating, clear cleansing compositions with relatively low pH |
| CN102958569A (en) * | 2010-06-24 | 2013-03-06 | 强生消费者公司 | Low-irritating, clear cleansing compositions with relatively low PH |
-
2017
- 2017-09-30 CN CN201710913723.4A patent/CN109589273A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1228804A (en) * | 1996-07-03 | 1999-09-15 | 普罗克特和甘保尔公司 | Cleansing compositions |
| CN1449735A (en) * | 2002-03-28 | 2003-10-22 | 莱雅公司 | Foam cosmetic composition for cleaning or dress taking off |
| US20110139170A1 (en) * | 2008-08-18 | 2011-06-16 | Thomas Hippe | Non-sulfate mild surfactant system for skin and hair cleaning |
| CN102958568A (en) * | 2010-06-24 | 2013-03-06 | 强生消费者公司 | Low-irritating, clear cleansing compositions with relatively low pH |
| CN102958569A (en) * | 2010-06-24 | 2013-03-06 | 强生消费者公司 | Low-irritating, clear cleansing compositions with relatively low PH |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2605159T3 (en) | Structured compositions comprising betaine | |
| EP1468666B1 (en) | Hair shampoo composition | |
| US20090005460A1 (en) | Methods of making and using structured compositions comprising betaine | |
| RU2694893C2 (en) | Compositions containing ammonium alkanoate zwitterionate ester | |
| CN105902411A (en) | Cleansing foam and preparation method thereof | |
| CN101390816A (en) | Formulation of tea saponin shampoo and production technique thereof | |
| CN103505375B (en) | Liquid detergent composition | |
| KR20180108833A (en) | Personal hygiene compositions and methods of using such compositions | |
| JP4467712B2 (en) | Cleaning composition | |
| CN105853271A (en) | Personnel cleaning composition containing Tuwei rose flower extract | |
| CN107595735A (en) | A kind of amino acid cleansing breast containing folium artemisiae argyi and preparation method thereof | |
| WO2000061099A1 (en) | Aqueous cosmetic product which contains tartaric or citric acid esters of the alkyl polyglucose and an acidic active substance with preservative properties | |
| CN110215425A (en) | A kind of hair washing shower bubble | |
| DE60309121T2 (en) | Aqueous hair cleansing composition | |
| CN112891252A (en) | Mild itching-relieving bath composition and preparation method thereof | |
| CN113197790A (en) | Three-in-one amino acid water and color removing mousse and preparation method thereof | |
| KR102327219B1 (en) | Low irritant personal cleansing composition having improved capacity for forming foam and stability | |
| CN109589273A (en) | Low irritant body cleanser composition | |
| CN103509655B (en) | Non-pneumatic bubbling container fills liquid detergent | |
| CN106265110B (en) | Surfactant composition | |
| CN114366693A (en) | Shampoo shower gel for infants and children | |
| KR20110014915A (en) | Conditioning shampoo composition | |
| KR101999121B1 (en) | Low irritant personal cleansing composition having improved capacity for forming foam and stability | |
| CN107648061B (en) | Shampoo with dandruff removing, nourishing and pearly luster and preparation method thereof | |
| DE10034636A1 (en) | Mild aqueous cosmetics for hair and skin contain hydroxy-substituted di- or tri-carboxylic acid esters and fatty acid partial glycerides |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |