CN109568789A - Myocardial infarction or cerebral apoplexy first-aid apparatus - Google Patents
Myocardial infarction or cerebral apoplexy first-aid apparatus Download PDFInfo
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- CN109568789A CN109568789A CN201811202102.6A CN201811202102A CN109568789A CN 109568789 A CN109568789 A CN 109568789A CN 201811202102 A CN201811202102 A CN 201811202102A CN 109568789 A CN109568789 A CN 109568789A
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- myocardial infarction
- cerebral apoplexy
- aid apparatus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
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Abstract
The present invention provides a kind of myocardial infarction or cerebral apoplexy first-aid apparatus, and the fixation device of patient's abdomen navel peripheral region is fixed on including pain generation device and by the pain generation device.When patient shows myocardial infarction or brain soldier's symptom, patient abdomen clothing is started to expose skin of abdomen, then pain generation device is fixed on patient's abdomen navel peripheral region, nociception induction can be started and adapt to (NIC), to reduce infarct size, improve prognosis, for after the onset and emergency tender transport on the way, i.e., arrival hospital rescue before strive for valuable time.
Description
Technical field
The present invention relates to a kind of emergency medical articles in emergency circumstances used in myocardial infarction or cerebral apoplexy etc..
Background technique
Acute myocardial infarction AMI (AMI) and cerebral apoplexy are Etiologicals that is lethal in the world and disabling, and timely Reperfu- sion can
Effectively to reduce infarct size, improves patient survival and improve prognosis, be the standard treatment of acute myocardial infarction AMI.However,
Clinically, not in time due to reperfusion therapy, 25% patient can be further developed into after suffering from myocardial infarction (MI) for
Heart failure (HF), and 50% patient can be dead in 5 years.
1986, Murry etc. [1] first proposed ischemic preconditioning (IPC), they have found in canine model, are having
Transient ischemia/Reperfu- sion (I/R) symptom occurred before harmful ischaemic/Reperfu- sion (I/R) breaking-out, can reduce the heart
Flesh infarct size.IPC phenomenon is confirmed in multiple animal species, including dog, rat, pig, rabbit and mouse, and
It is also confirmed that in human patients [2-7], the document that sees reference [8].
Later, McClanahan etc. [9] was also confirmed that, even if the ischemic pre-adaptation at remote organ (such as kidney) stimulates
Also myocardial preservation can be activated.Some researches show that, after kidney, intestines, limbs, liver, skeletal muscle and cerebral ischemia occurs, remote ischemic
Pre-adaptation (RIPC) can activate myocardial preservation mechanism (document that sees reference [10])
Long-range pre-adaptation, which refers to apply during myocardial infarction (MI) breaking-out in distal end, adapts to sexual stimulus, result of study table
Bright, long-range pre-adaptation has protective effect and clinical value [11].However, all myocardial preservation strategies have its limitation.
The reason is that these strategies need to implement ischemic sexual stimulus to a certain organ, and clinically usually it is unable to satisfy this requirement.In addition,
Also very disappointing [12], they have great limitation and risk to the clinical test results of these methods, and hinder
The applications [13,14] of these methods clinically.
In fact, the release that sex factor is spread in ischemic pre-adaptation tissue (organ) is only the key [15-19] of RIPC, institute
These myocardial preservation " adaptation " phenomenons indicate myocardial preservation mechanism starting be from cardiac muscle adapt to net (containing particular medium
With cardiac muscle cell survive receptor) different points of penetration carry out, the point of penetration include NF- κ B, Stat3/5, protein kinase C,
Bradykinin and the channel mitoKATP.For example, peptide bradykinin is required in ischemic pre-adaptation and rear adaptation process
Substance [20,21], andDeng and Shoemaker etc. also confirm for the first time its during RIPC property of participation [22,
23]
2004, in the article that we deliver, we describe the myocardial preservation effects of operation on skin notch, together
When new term, i.e., long-range wound pre-adaptation (RPCT) have been named for this effect.In short, we demonstrate that abdomen navel peripheral region
Operative incision can cause myocardial preservation, to weaken secondary ischemic damage, while myocardial infarction area is reduced 80%
~85%.Different from IPC and RIPC institute, RPCT is without ischemic dependence but has very high protective effect.It is similar to RIPC,
RPCT requires complete nerve connection [24], under study for action, it has been found that carries out to the spinal cord (T7) of thoracic vertebrae Section 7 section level
Crosscutting to block protective effect but crosscutting without this effect to the progress of the spinal cord (C7) of cervical vertebra Section 7 section level, this illustrates its height
Position central nervous system (CNS) is not involved in this adjustment effect, but the integrality pair of the spinal segment between navel and heart
The adjusting of RPCT and conduction are required.And RPCT also has protective effect early and late as IPC.
The starting for being characterized in that its protective effect of RPCT and privileged site --- navel week two sides skin peripheral nerve stimulation
Related [24,25].
It was found that the nociception of skin and chemical stimulation and other pain can cause corresponding guarantor in follow-up study
Shield effect, the fact that being based on, we have proposed new term, i.e. nociception induction adapts to (NIC), it is more extensive to be used to refer to generation
Effect (by notch, chemistry or we will be seen that electrical method activation effectiveness).
Our research demonstrates the Related Mechanism that nociception induction adapts to (NIC), i.e. activation preabdomen is (close to T9-
Signal can be uploaded to the segment of T1-5 by skin damage receptor T10) from the neuromere of T9-10, then anti-through Dorsal Root
It penetrates arc mechanism (DRG) and is transmitted to heart, to generate the reverse property signal by heart affective neuron to heart.In heart,
Sensory nerve can discharge CGRP and P neuroactive substance, to cause the NE release from sympathetic nerve, and come from sensory nerve
Or the release [26] of the bradykinin of sympathetic nerve.NE and/or bradykinin to a certain extent can act on cardiac muscle cell's generation, together
When can activate PKC signal path, and then the activity of adjustment signal and end-effector, including the channel mitochondria KAXP [24,27].
It is adapted to by the cardiac muscle that triggering stomodaeal nervous system mediates, " the warning letter of the distal end cutaneous nerve of spinal cord conduction can be responded
Number ", to activate myocardial preservation.
Basic Research Results based on early period, electro photoluminescence activation abdomen sensory nerve --- skin electrocautery is utilized in we
(EA), come explore it is a kind of start NIC easy, noninvasive method.Meanwhile in experimenting, we find out that, is stimulated using capsaicine
The long-range electro photoluminescence of identical skin area can equally activate myocardial preservation, which has been obtained confirmation [24]).
The cardioprotection that is found to be of RPCT provides important treatment strategies from myocardium I/R damage, opens exploration and opens
The gate of dynamic myocardial preservation new model.Some in these modes are effective [28] in several animal models and human body.
Under study for action, it has been found that, abdomen sensory nerve is activated by electro photoluminescence, it, not only can be right after Lai Qidong NIC
Cardiac muscle generates protecting effect, equally has protecting effect to the prognosis of cerebral apoplexy.(research achievement waits delivering)
Bibliography
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7.L.K.Teoh,R.Grant,J.A.Hulf,W.B.Pugsley,D.M.Yellon.A comparison
between ischemic preconditioning,intermittent cross-clamp fibrillation and
cold crystalloid cardioplegia for myocardial protection during coronary
artery bypass graft surgery.Cardiovasc.Surg.,2002,10(3):251–255
8.G.Heusch.Cardioprotection:Chances and challenges of its translation
to the clinic.Lancet,2013,381(9861):166–175
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K.P.Gallagher.Brief renal occlusion and reperfusion reduces myocardial
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Summary of the invention
The object of the present invention is to provide a kind of myocardial infarction or cerebral apoplexy first-aid apparatuses, can obstruct in first time to cardiac muscle
Dead or patients with cerebral apoplexy provides treatment, receives professional treatment to large hospital for transhipment patient in next step and tries to gain time precious to one, from
And reduce the death rate of patient.
To achieve the above object, the technical solution adopted by the present invention is that:
A kind of myocardial infarction or cerebral apoplexy first-aid apparatus, it is characterized in that including pain generation device and by pain production
Generating apparatus is fixed on the fixation device of patient's abdomen navel peripheral region.
The myocardial infarction or cerebral apoplexy first-aid apparatus, in which: the fixed device is waistband.
The myocardial infarction or cerebral apoplexy first-aid apparatus, in which: the both ends of the waistband are by hasp, devil's felt or are
Rope mode is connected.
The myocardial infarction or cerebral apoplexy first-aid apparatus, in which: the waistband is flexible sealing ring.
The myocardial infarction or cerebral apoplexy first-aid apparatus, in which: the fixed device is adhesive plaster.
The myocardial infarction or cerebral apoplexy first-aid apparatus, in which: the pain generation device capsaicine.
The myocardial infarction or cerebral apoplexy first-aid apparatus, in which: the capsaicine other components that undope are either mixed
It is miscellaneous in gel.
The myocardial infarction or cerebral apoplexy first-aid apparatus, in which: the pain generation device is electrode plate.
The myocardial infarction or cerebral apoplexy first-aid apparatus, in which: the electrode plate can pass through power supply line and external electricity
Source connects, alternatively, the myocardial infarction or cerebral apoplexy first-aid apparatus, in which: the electrode plate is connected with battery, the battery
It is fixed in the fixed device.
The myocardial infarction or cerebral apoplexy first-aid apparatus, in which: the electrode plate can discharge 8-12V, 80-120Hz,
Pulse width is the electric current of 300-500ms.
Compared with prior art, the invention has the advantages that: when patient shows myocardial infarction or brain soldier's disease
When shape, patient abdomen clothing is started to expose skin of abdomen, pain generation device is then fixed on patient's abdomen navel peripheral region
Domain can start nociception induction and adapt to (NIC), to reduce infarct size, improve prognosis, for after the onset and emergency tender
It transports on the way, i.e., strives for valuable time before the rescue of arrival hospital.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of myocardial infarction of the present invention or cerebral apoplexy first-aid band；
Fig. 2 is the structural schematic diagram of myocardial infarction of the present invention or cerebral apoplexy emergency paste.
Description of symbols: waistband 1；Electrode plate 2；Power supply line 3；Adhesive plaster 4；Capsaicine 5；Gel 6.
Specific embodiment
Myocardial infarction provided by the invention or cerebral apoplexy first-aid apparatus, main includes pain generation device and by the pain
Sense generation device is fixed on the fixation device of patient's abdomen navel peripheral region.
As shown in Figure 1, being a kind of myocardial infarction provided by the invention or cerebral apoplexy first-aid band, the fixation device for including is one
The both ends of root waistband 1, waistband 1 can be connected by hasp, devil's felt or tether mode or waistband 1 is flexible closing
Circle, enables waistband 1 to be fastened in patient's waist；And the pain generation device is fixed on waistband 1 or in waistband 1
Electrode plate 2, the electrode plate 2 can be connected by power supply line 3 with commercial power socket (or emergency power supply, vehicle power supply), with
Obtain electric power；In addition, the electrode plate 2 can also be provided electric power by battery, and battery is directly anchored in waistband, in order to take
Band is moved with patient.
When patient shows myocardial infarction or brain soldier's symptom, patient abdomen clothing is started to expose skin of abdomen, so
Waistband 1 is fastened in the waist of patient afterwards, and electrode plate 2 is placed in corresponding patient's abdomen navel peripheral region, then by power supply line 3
It is connected to power outlet, turning on the switch makes electrode plate 2 discharge, and electrode plate 2 can discharge 10V, 100Hz, pulse width to patient
For the electric current of 400ms, nociception induction can be started and adapt to (NIC), to reduce infarct size, improve prognosis, to send out
After being ill and emergency tender transports on the way, i.e., strives for valuable time before the rescue of arrival hospital.
Please referred to shown in Fig. 2 again, be a kind of myocardial infarction provided by the invention or cerebral apoplexy emergency paste, it includes fixation
Device is adhesive plaster 4, and it includes pain generation device be the capsaicine 5 for being fixed on the adhesive surface side of adhesive plaster 4, the capsicum
Element 5 can undope other components, be also possible to be mingled in gel 6.
When patient shows myocardial infarction or brain soldier's symptom, patient abdomen clothing is started to expose skin of abdomen, so
It is attached to patient's abdomen navel peripheral region after emergency paste is torn protective film afterwards, nociception induction can be started and adapt to (NIC), from
And reduce infarct size, improve prognosis, for after the onset and emergency tender transports on the way, i.e., strive for before the rescue of arrival hospital it is valuable
Time.
Above-mentioned two embodiment can also be replaced mutually, such as electrode plate 2 is fixed with adhesive plaster 4, or capsaicine 5 is consolidated
It is scheduled on 1 inside of waistband, is all feasible embodiment.
It is verified by experimental study, the present invention can effectively improve the prognosis of myocardial infarction and cerebral apoplexy really, therefore
With extensive market prospects, there is the family of cardiovascular and cerebrovascular disease, there is family and the cardiovascular and cerebrovascular diseases group of people at high risk of old man, it is small-sized
First-aid station, emergency tender and outdoor sports can be equipped with such myocardial infarction cerebral apoplexy first-aid apparatus, can turn for next step
Fortune patient receives professional treatment to large hospital and tries to gain time precious to one, to reduce the death rate of patient.
Claims (10)
1. a kind of myocardial infarction or cerebral apoplexy first-aid apparatus, it is characterized in that including pain generation device and generating the pain
Device is fixed on the fixation device of patient's abdomen navel peripheral region.
2. myocardial infarction according to claim 1 or cerebral apoplexy first-aid apparatus, it is characterised in that: the fixed device is waist
Band.
3. myocardial infarction according to claim 2 or cerebral apoplexy first-aid apparatus, it is characterised in that: the both ends of the waistband are logical
Hasp, devil's felt or tether mode is crossed to be connected.
4. myocardial infarction according to claim 2 or cerebral apoplexy first-aid apparatus, it is characterised in that: the waistband is with bullet
The sealing ring of property.
5. myocardial infarction according to claim 1 or cerebral apoplexy first-aid apparatus, it is characterised in that: the fixed device is glue
Cloth.
6. myocardial infarction according to claim 1 or cerebral apoplexy first-aid apparatus, it is characterised in that: the pain generation device
Capsaicine.
7. myocardial infarction according to claim 6 or cerebral apoplexy first-aid apparatus, it is characterised in that: the capsaicine undopes
Other components are either mingled in gel.
8. myocardial infarction according to claim 1 or cerebral apoplexy first-aid apparatus, it is characterised in that: the pain generation device
It is electrode plate.
9. myocardial infarction according to claim 8 or cerebral apoplexy first-aid apparatus, it is characterised in that: the electrode plate can lead to
Power supply line is crossed to connect with external power supply；Alternatively, the electrode plate is connected with battery, the battery is fixed on the fixed device
It is interior.
10. myocardial infarction according to claim 8 or cerebral apoplexy first-aid apparatus, it is characterised in that: the electrode plate can
Discharge 8-12V, 80-120Hz, the electric current that pulse width is 300-500ms.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810730932 | 2018-07-05 | ||
| CN201810730932X | 2018-07-05 |
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|---|---|
| CN109568789A true CN109568789A (en) | 2019-04-05 |
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ID=65920113
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| CN201811202102.6A Pending CN109568789A (en) | 2018-07-05 | 2018-10-16 | Myocardial infarction or cerebral apoplexy first-aid apparatus |
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Citations (4)
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| CN204092847U (en) * | 2014-08-13 | 2015-01-14 | 上海交通大学 | A kind of distributed multi-channel nerve electric stimulation instrument |
| CN105726011A (en) * | 2016-01-26 | 2016-07-06 | 天津工业大学 | Health monitoring garment |
| CN107921237A (en) * | 2015-04-27 | 2018-04-17 | 反射医学公司 | Sympathetic nerve cardiopulmonary neural modulation system and method |
| US20200015698A1 (en) * | 2018-07-14 | 2020-01-16 | Wen-Pin Chou | First-Aid Device for Detecting Myocardial Infarction |
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2018
- 2018-10-16 CN CN201811202102.6A patent/CN109568789A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204092847U (en) * | 2014-08-13 | 2015-01-14 | 上海交通大学 | A kind of distributed multi-channel nerve electric stimulation instrument |
| CN107921237A (en) * | 2015-04-27 | 2018-04-17 | 反射医学公司 | Sympathetic nerve cardiopulmonary neural modulation system and method |
| CN105726011A (en) * | 2016-01-26 | 2016-07-06 | 天津工业大学 | Health monitoring garment |
| US20200015698A1 (en) * | 2018-07-14 | 2020-01-16 | Wen-Pin Chou | First-Aid Device for Detecting Myocardial Infarction |
Non-Patent Citations (1)
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