CN109568666A - Gd:Fe3O4@RA复合纳米分子用于脊髓神经损伤的修复及MRI造影方法 - Google Patents
Gd:Fe3O4@RA复合纳米分子用于脊髓神经损伤的修复及MRI造影方法 Download PDFInfo
- Publication number
- CN109568666A CN109568666A CN201811504784.6A CN201811504784A CN109568666A CN 109568666 A CN109568666 A CN 109568666A CN 201811504784 A CN201811504784 A CN 201811504784A CN 109568666 A CN109568666 A CN 109568666A
- Authority
- CN
- China
- Prior art keywords
- stem cell
- added
- nanoparticle
- rat
- neural stem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811504784.6A CN109568666B (zh) | 2018-12-10 | 2018-12-10 | Gd:Fe3O4@RA复合纳米分子用于脊髓神经损伤的修复及MRI造影方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811504784.6A CN109568666B (zh) | 2018-12-10 | 2018-12-10 | Gd:Fe3O4@RA复合纳米分子用于脊髓神经损伤的修复及MRI造影方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109568666A true CN109568666A (zh) | 2019-04-05 |
CN109568666B CN109568666B (zh) | 2021-02-02 |
Family
ID=65927940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811504784.6A Active CN109568666B (zh) | 2018-12-10 | 2018-12-10 | Gd:Fe3O4@RA复合纳米分子用于脊髓神经损伤的修复及MRI造影方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN109568666B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112426440A (zh) * | 2020-10-21 | 2021-03-02 | 浙江大学 | 一种干细胞制剂及其制备方法和应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102167813A (zh) * | 2011-01-19 | 2011-08-31 | 兰州大学 | 一种荧光示踪纳米磁共振成像造影剂 |
TW201515663A (zh) * | 2013-02-08 | 2015-05-01 | Univ Nat Cheng Kung | 核磁共振對比增強顯影劑 |
CN105288662A (zh) * | 2015-10-22 | 2016-02-03 | 湖北大学 | 一种t1-t2双模态mri造影剂及其制备方法和应用 |
US20180008730A1 (en) * | 2014-08-11 | 2018-01-11 | William Marsh Rice University | Multifunctional fluorescent and mri-active nanostructure |
-
2018
- 2018-12-10 CN CN201811504784.6A patent/CN109568666B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102167813A (zh) * | 2011-01-19 | 2011-08-31 | 兰州大学 | 一种荧光示踪纳米磁共振成像造影剂 |
TW201515663A (zh) * | 2013-02-08 | 2015-05-01 | Univ Nat Cheng Kung | 核磁共振對比增強顯影劑 |
US20180008730A1 (en) * | 2014-08-11 | 2018-01-11 | William Marsh Rice University | Multifunctional fluorescent and mri-active nanostructure |
CN105288662A (zh) * | 2015-10-22 | 2016-02-03 | 湖北大学 | 一种t1-t2双模态mri造影剂及其制备方法和应用 |
Non-Patent Citations (2)
Title |
---|
FENFEN LI等: "Core shell Fe3O4 Gd2O3 nanocubes as T1–T2 dual modal MRI contrast agents", 《THE ROYAL SOCIETY OF CHEMISTRY》 * |
赵冀安等: "β干扰素联合全反式维甲酸通过抑制JAK2/STAT3信号通路抑制HepG2人肝癌细胞增殖并促进其凋亡", 《细胞与分子免疫学杂志》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112426440A (zh) * | 2020-10-21 | 2021-03-02 | 浙江大学 | 一种干细胞制剂及其制备方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
CN109568666B (zh) | 2021-02-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN109536448A (zh) | 一种多功能负载维甲酸的钆参杂四氧化三铁复合纳米粒子 | |
Vaquero et al. | An approach to personalized cell therapy in chronic complete paraplegia: The Puerta de Hierro phase I/II clinical trial | |
CN109517794A (zh) | Gd:Fe3O4@RA纳米粒子诱导神经干细胞定向分化为神经元细胞的方法 | |
CN102413834B (zh) | 聚合月桂烯的组合物 | |
WO2011147967A1 (en) | Skeletal muscle regeneration using mesenchymal stem cells | |
CN113045528B (zh) | 一种金属-儿茶素复合纳米材料及其制备方法与应用 | |
RU2394593C2 (ru) | Имплантируемая нейроэндопротезная система, способ ее получения и способ проведения реконструктивной нейрохирургической операции | |
CN108753682A (zh) | 促内皮细胞成血管的外泌体活性制剂及其制备方法和应用 | |
CN102232970A (zh) | 一种治疗骨损伤细胞注射剂及其制备方法 | |
CN110179823A (zh) | 一种基于金属多酚配位的活细胞递送系统及其制备方法 | |
CN104212762B (zh) | 一种通过体外小分子诱导培养尿源性多潜能干细胞的方法 | |
CN110227163A (zh) | 一种外泌体载药体系及其在脊髓损伤修复中的应用 | |
CN104208704B (zh) | 一种pH敏感的碳纳米管靶向递药体系的制备方法 | |
CN109568666A (zh) | Gd:Fe3O4@RA复合纳米分子用于脊髓神经损伤的修复及MRI造影方法 | |
CN109568654A (zh) | 负载维甲酸的钆参杂四氧化三铁复合纳米粒子的制备方法 | |
Wang et al. | A bio-orthogonally functionalized chitosan scaffold with esterase-activatable release for nerve regeneration | |
CN108653732B (zh) | pH响应型四氧化三铁纳米粒及其制备方法与应用 | |
CN106310297B (zh) | 多功能高分子前药纳米递药系统及制备方法和用途 | |
CN102836429B (zh) | 修复受损组织的抗体靶向药物、给药方法及磁共振造影剂 | |
CN110237272A (zh) | 适用于mri/nir-ii的双模态肿瘤成像纳米探针、制备方法及应用 | |
CN113456587B (zh) | 一种靶向乳腺癌干细胞的谷胱甘肽响应型纳米药物载体制备及应用 | |
WO2020119174A1 (zh) | 一种多功能负载维甲酸的钆参杂四氧化三铁复合纳米粒子及其制备方法 | |
CN111281984B (zh) | 基于表面修饰的四氧化三铁磁性纳米探针及其制备和应用 | |
CN111920827B (zh) | 促组织愈合的复方缓释纳米粒的制备方法 | |
CN104623197A (zh) | 一种左归丸纳米微球缓释系统及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Guo Lingling Inventor after: Wang Guannan Inventor after: Jin Li Inventor after: Daichen Inventor after: Gao Haiyan Inventor after: Peng Jun Inventor before: Wang Guannan Inventor before: Jin Li Inventor before: Daichen Inventor before: Gao Haiyan Inventor before: Peng Jun |
|
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20210111 Address after: 121000 No. five, Section 2, Renmin Street, Guta District, Liaoning, Jinzhou Applicant after: The First Affiliated Hospital of Jinzhou Medical University Address before: 272067 No.133, Hehua Road, taibaihu New District, Jining City, Shandong Province Applicant before: JINING MEDICAL University |
|
GR01 | Patent grant | ||
GR01 | Patent grant |