CN109568561A - A kind of external application Chinese medicine agent for the treatment of of arthritis - Google Patents

A kind of external application Chinese medicine agent for the treatment of of arthritis Download PDF

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Publication number
CN109568561A
CN109568561A CN201910106407.5A CN201910106407A CN109568561A CN 109568561 A CN109568561 A CN 109568561A CN 201910106407 A CN201910106407 A CN 201910106407A CN 109568561 A CN109568561 A CN 109568561A
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parts
component
chinese medicine
treatment
external application
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任记红
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Liu Zhixing
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/58—Reptiles
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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Abstract

The present invention relates to tcm fields, treatment of arthritis medicine therapeutic effect is poor, slow effect aiming at the problem that, provide a kind of external application Chinese medicine agent for the treatment of of arthritis, the technical solution is as follows: including the first component and the second component, the mass parts ratio of the first component and the second component is 1:1-1.5；First component includes 120-160 parts of the component: Common St.Paulswort Herb of following mass fraction；10-20 parts of aconiti preparata,radix；10-15 parts of monkshood；10-17 parts of Radix Glycyrrhizae；30-35 parts of safflower；25-35 parts of caulis sinomenii；50-60 parts of caulis trachelospermi；55-62 parts of Caulis et Folium piperis；47-53 parts of rhizoma dioscoreae nipponicae；10-15 parts of radix achyranthis bidentatae；40-45 parts of ramulus cinnamomi；42-50 parts of herba taxilli；15-21 parts of ginger；Dry green pepper 55-63 parts, remaining is water and brown sugar；Second component includes the component of following mass fraction: 40-52 parts of zaocys dhumnade；15-20 parts of centipede；40-53 parts of scorpio；40-45 parts of ground bettle；10-15 parts of leech；15-23 parts of earthworm；40-52 parts of honeycomb, remaining is white wine.Resulting Chinese medicine is prepared by using above-mentioned medicinal material, there is effect significant in efficacy, quick to arthritis.

Description

A kind of external application Chinese medicine agent for the treatment of of arthritis
Technical field
The present invention relates to tcm fields, more specifically, it relates to a kind of external application Chinese medicine agent for the treatment of of arthritis.
Background technique
Arthritis refers to generation in human synovial and its surrounding tissue, by inflammation, infection, degeneration, wound or other factors Caused inflammatory disease can be divided into tens of kinds.Clinical relatively conventional arthritis has following several: osteoarthritis, rheumatic are closed Save inflammation, rheumatoid arthritis etc..
The method for the treatment of of arthritis has much at present, existing doctor trained in Western medicine medicament, also there is Chinese medicine medicament, and Chinese medicine medicament further includes interior Clothes and external application still the problem of either which kind of medicament, generally existing curative effect is poor, slow effect, therefore, still have and change Into space.
Summary of the invention
In view of the deficiencies of the prior art, the present invention intends to provide a kind of external application Chinese medicine for the treatment of of arthritis Agent has the advantages that curative effect is good, quick.
To achieve the above object, the present invention provides the following technical scheme that
A kind of external application Chinese medicine agent for the treatment of of arthritis, including the first component and the second component, first component and second The mass parts ratio of component is 1:1-1.5；
First component includes 120-160 parts of the component: Common St.Paulswort Herb of following mass fraction；10-20 parts of aconiti preparata,radix；Monkshood 10-15 parts；10-17 parts of Radix Glycyrrhizae；30-35 parts of safflower；25-35 parts of caulis sinomenii；50-60 parts of caulis trachelospermi；55-62 parts of Caulis et Folium piperis；It wears Dragon 45-53 parts of mountain；10-15 parts of radix achyranthis bidentatae；40-45 parts of ramulus cinnamomi；42-50 parts of herba taxilli；15-21 parts of ginger；Dry green pepper 55-63 parts, remaining For water and brown sugar；
Second component includes the component of following mass fraction: 40-52 parts of zaocys dhumnade；15-20 parts of centipede；Scorpio 40- 53 parts；40-45 parts of ground bettle；10-15 parts of leech；15-23 parts of earthworm；40-52 parts of honeycomb, remaining is white wine.
The present invention is further arranged to: first component includes the component: Common St.Paulswort Herb 145-155 of following mass fraction Part；13-15 parts of aconiti preparata,radix；14-15 parts of monkshood；13-16 parts of Radix Glycyrrhizae；30-32 parts of safflower；28-32 parts of caulis sinomenii；Caulis trachelospermi 54- 60 parts；58-61 parts of Caulis et Folium piperis；45-50 parts of rhizoma dioscoreae nipponicae；13-15 parts of radix achyranthis bidentatae；43-45 parts of ramulus cinnamomi；42-45 parts of herba taxilli；Ginger 18- 21 parts；Dry green pepper 58-60 parts, remaining is water and brown sugar；
Second component includes the component of following mass fraction: 40-45 parts of zaocys dhumnade；18-20 parts of centipede；Scorpio 40- 48 parts；43-45 parts of ground bettle；10-13 parts of leech；15-20 parts of earthworm；40-45 parts of honeycomb, remaining is white wine.
By adopting the above technical scheme, by using the external application Chinese medicine agent of the treatment of arthritis of the brewed formation of above-mentioned medicinal material, with Upper medicinal material has effects that dispelling rheumatism and relieving pain, blood circulation, removing blood stasis and acesodyne, meanwhile, zaocys dhumnade, centipede and scorpio etc. also have one Fixed toxicity is conducive to inhibit zaocys dhumnade, centipede and complete by the specific ratio cooperation of various medicinal materials mutually to act synergistically The toxicity of scorpion etc. makes it play the effect of dispelling rheumatism and relieving pain, is conducive to the therapeutic effect for improving Chinese medicine, so that the curative effect of Chinese medicine Significantly, quick, meanwhile, good curative effect is all had to various rheumatic and rheumatoids, scapulohumeral periarthritis and periostitis；In addition, in this Medicament is external application Chinese medicine agent, and only need to be applied to ailing place can treat arthritis, easy to operate, safe, quick, is suffered from Person need to only smear 5-10 days, that is, can produce the effect being clearly better.
The present invention is further arranged to: the mass parts ratio of first component and the second component is 1:1.
By adopting the above technical scheme, it is 1:1 by the mass parts ratio of the first component of control and the second component, is conducive to increase The drug effect of strong Chinese medicine, so that therapeutic effect is more obvious.
The present invention is further arranged to: the preparation method of the arthritic external application Chinese medicine agent the following steps are included:
S1, water removal in the first component or other each components other than white wine are put into fermentor in mass fraction ratio, It adds water and ferments 3 months with brown sugar；
S2, other each components in the second component in addition to white wine are put into steeping tank in mass fraction ratio, then plus Soaking in Chinese liquor 3 months；
S3, ratio of the resulting liquid by mass parts ratio for 1:1-1.5 will be impregnated in ferment in S1 resulting liquid and S2 Example mixing, is placed one month.
By adopting the above technical scheme, by fermenting and impregnating so that the essential ingredient in medicinal material is extracted into liquid, The drug effect for being conducive to improve Chinese medicine, so that the therapeutic effect of Chinese medicine is more preferable；Meanwhile through everfermentation and after impregnating, be conducive to Drug effect molecule forms nanoscale molecular, so that Chinese medicine is easier to infiltrate into ailing place when smearing, to be conducive in enhancing The curative effect of medicament, so that Chinese medicine takes effect faster, while it is easy to recur that illness is not allowed, and is conducive to the radical cure of illness；Second Component is mostly band toxicant, produces Chinese medicine by using the mode of soaking in Chinese liquor, white wine has certain disinfection and sterilization Function is conducive to inhibit its toxicity, so that its drug effect is stronger, while being conducive to keep the quality of Chinese medicine, obtains so that extracting Chinese medicine be not easy to be contaminated；In addition, placing one after extracting resulting liquid by the first component of mixing and the second component It month reuses, is conducive to being sufficiently mixed for the first component and the second component, thus be conducive to the drug effect of raising Chinese medicine, so that in The therapeutic effect of medicament is more preferable, takes effect faster.
The present invention is further arranged to: in first component water removal and brown sugar other than other each components summation and water Mass parts ratio with brown sugar is 3:6:1.
By adopting the above technical scheme, by control the first component in water removal and brown sugar other than other each components summation and The mass parts ratio of water and brown sugar is 3:6:1, so that the concentration for the fermentation liquid that brown sugar and water are formed is more suitable for the extraction of medicinal material, is made The effective component obtained in medicinal material is easier to be extracted, so that the effective component in Chinese medicine increases, and then is conducive to The drug effect of enhancing Chinese medicine takes effect faster so that the therapeutic effect of Chinese medicine is more preferable；Meanwhile by the way that brown sugar is added, brown sugar is also Conducive to the nutrient composition content improved in medicament.
The present invention is further arranged to: in the step S1 and step S2, fermentation and the temperature impregnated control 35 DEG C- 45℃。
By adopting the above technical scheme, the temperature condition fermented and impregnated by control is 35 DEG C -45 DEG C, so that in medicinal material Effective component is easier to be extracted, so that the active constituent content prepared in resulting Chinese medicine increases, so that in The drug effect of medicament is stronger, so that the more remarkable treatment effect of Chinese medicine, taking effect faster.
The present invention is further arranged to: in the step S2, the degree of the white wine for immersion is 60 ° -65 °.
The present invention is further arranged to: in the step S2, the degree of the white wine for immersion is 60 °.
It by adopting the above technical scheme, is 60 ° by controlling the degree of the white wine for impregnating, so that the concentration of white wine is more suitable In the extraction of medicinal material, so that the effective component in medicinal material is easier to be extracted, to be conducive to increase having in Chinese medicine Ingredient is imitated, so that the drug effect of Chinese medicine enhances, and then is conducive to enhance the therapeutic effect of Chinese medicine, so that Chinese medicine takes effect more Fastly.
The present invention is further arranged to: in the step S2, the white wine for immersion is liquor made from sorghum.
By adopting the above technical scheme, by using liquor made from sorghum as the white wine for impregnating medicinal material, liquor made from sorghum has splendid Antisepsis and permeability, be conducive to extend the holding time of Chinese medicine, meanwhile, the alcohol of liquor made from sorghum is easier to enter medicinal material Histocyte in, play dissolution, be conducive to improve leaching efficiency and leaching effect, so that the effective component in medicinal material is more It is easy to be extracted, so that the drug effect for being conducive to enhance Chinese medicine takes effect faster so that the therapeutic effect of Chinese medicine is more preferable.
In conclusion the invention has the following advantages:
1. extracting the effective component in medicinal material by using the mode of fermentation and soaking in Chinese liquor, be conducive to improve in Chinese medicine The purity of effective component, so that the therapeutic effect of Chinese medicine is more preferable, take effect faster so that the drug effect of Chinese medicine enhances；
2. extracting the effective component in medicinal material by way of fermenting with soaking in Chinese liquor, be conducive to the effective component in medicinal material Nanoscale molecular is formed, so that Chinese medicine is easier to infiltrate into ailing place when smearing, to be conducive to enhance the treatment of Chinese medicine Effect so that illness is not allowed easy to recur, is conducive to the radical cure of illness so that Chinese medicine takes effect faster；
3. this Chinese medicine is external application Chinese medicine agent, need to only be applied to ailing place can to rheumatism and rheumatoid arthritis into Row treatment, easy to operate, safe, quick, patient need to only smear 5-10 days, that is, can produce the effect being clearly better.
Specific embodiment
With reference to embodiments, invention is further described in detail.
Embodiment 1
A kind of external application Chinese medicine agent for the treatment of of arthritis, including the first component and the second component；
First component includes the component of following mass fraction:
Common St.Paulswort Herb 120g；Aconiti preparata,radix 10g；Monkshood 10g；Radix Glycyrrhizae 10g；Safflower 30g；Caulis sinomenii 25g；Caulis trachelospermi 50g；Heath Rattan 55g；Rhizoma dioscoreae nipponicae 45g；Radix achyranthis bidentatae 10g；Ramulus cinnamomi 40g；Herba taxilli 42g；Ginger 15g；Dry green pepper 55g；Water 1038g；Brown sugar 173g；
Second component includes the component of following mass fraction:
Zaocys dhumnade 40g；Centipede 15g；Scorpio 40g；Ground bettle 40g；Leech 10g；Earthworm 15g；Honeycomb 40g；White wine 1530g。
The external application Chinese medicine agent for the treatment of of arthritis the preparation method is as follows:
S1, in the fermenter Jia Ru Common St.Paulswort Herb 120g, aconiti preparata,radix 10g, monkshood 10g, Radix Glycyrrhizae 10g, safflower 30g, caulis sinomenii It is 25g, caulis trachelospermi 50g, Caulis et Folium piperis 55g, rhizoma dioscoreae nipponicae 45g, radix achyranthis bidentatae 10g, ramulus cinnamomi 40g, herba taxilli 42g, ginger 15g, dry green pepper 55g, red Sugared 173g, then 1038g water is poured into, sealed fermenter, controlling the temperature in fermentor is 35 DEG C, is fermented 3 months；
S2, in steeping tank be added zaocys dhumnade 40g, centipede 15g, scorpio 40g, ground bettle 40g, leech 10g, earthworm 15g, Honeycomb 40g, then 60 ° of white wine 1530g is poured into, sealed soak tank, controlling the temperature in steeping tank is 35 DEG C, is impregnated 3 months；
S3, solid medicinal material in fermentor and steeping tank is discarded, taken in the fermentation liquid 1kg and steeping tank in fermentor Extracting solution 1kg mixing, under room temperature item, the external application Chinese medicine agent to get treatment of arthritis in 1 month is placed in sealing.
Embodiment 2
A kind of external application Chinese medicine agent for the treatment of of arthritis, including the first component and the second component；
First component includes the component of following mass fraction:
Common St.Paulswort Herb 145g；Aconiti preparata,radix 13g；Monkshood 14g；Radix Glycyrrhizae 13g；Safflower 30g；Caulis sinomenii 28g；Caulis trachelospermi 54g；Heath Rattan 58g；Rhizoma dioscoreae nipponicae 45g；Radix achyranthis bidentatae 13g；Ramulus cinnamomi 43g；Herba taxilli 42g；Ginger 18g；Dry green pepper 58g；Water 1152g；Brown sugar 192g；
Second component includes the component of following mass fraction:
Zaocys dhumnade 40g；Centipede 18g；Scorpio 40g；Ground bettle 43g；Leech 10g；Earthworm 15g；Honeycomb 40g；White wine 2290g。
The external application Chinese medicine agent for the treatment of of arthritis the preparation method is as follows:
S1, in the fermenter Jia Ru Common St.Paulswort Herb 145g, aconiti preparata,radix 13g, monkshood 14g, Radix Glycyrrhizae 13g, safflower 30g, caulis sinomenii It is 28g, caulis trachelospermi 54g, Caulis et Folium piperis 58g, rhizoma dioscoreae nipponicae 45g, radix achyranthis bidentatae 13g, ramulus cinnamomi 43g, herba taxilli 42g, ginger 18g, dry green pepper 58g, red Sugared 192g, then 1152g water is poured into, sealed fermenter, controlling the temperature in fermentor is 37 DEG C, is fermented 3 months；
S2, in steeping tank be added zaocys dhumnade 40g, centipede 18g, scorpio 40g, ground bettle 43g, leech 10g, earthworm 15g, Honeycomb 40g, then 61 ° of white wine 2290g is poured into, sealed soak tank, controlling the temperature in steeping tank is 37 DEG C, is impregnated 3 months；
S3, solid medicinal material in fermentor and steeping tank is discarded, taken in the fermentation liquid 1kg and steeping tank in fermentor Extracting solution 1.3kg mixing, under room temperature item, the external application Chinese medicine agent to get treatment of arthritis in 1 month is placed in sealing.
Embodiment 3
A kind of external application Chinese medicine agent for the treatment of of arthritis, including the first component and the second component；
First component includes the component of following mass fraction:
Common St.Paulswort Herb 155g；Aconiti preparata,radix 15g；Monkshood 15g；Radix Glycyrrhizae 16g；Safflower 32g；Caulis sinomenii 32g；Caulis trachelospermi 60g；Heath Rattan 61g；Rhizoma dioscoreae nipponicae 50g；Radix achyranthis bidentatae 15g；Ramulus cinnamomi 45g；Herba taxilli 45g；Ginger 21g；Dry green pepper 60g；Water 1244g；Brown sugar 207g；
Second component includes the component of following mass fraction:
Zaocys dhumnade 45g；Centipede 20g；Scorpio 48g；Ground bettle 45g；Leech 13g；Earthworm 20g；Honeycomb 45g；White wine 2873.5g。
The external application Chinese medicine agent for the treatment of of arthritis the preparation method is as follows:
S1, in the fermenter Jia Ru Common St.Paulswort Herb 155g, aconiti preparata,radix 15g, monkshood 15g, Radix Glycyrrhizae 16g, safflower 32g, caulis sinomenii It is 32g, caulis trachelospermi 60g, Caulis et Folium piperis 61g, rhizoma dioscoreae nipponicae 50g, radix achyranthis bidentatae 15g, ramulus cinnamomi 45g, herba taxilli 45g, ginger 21g, dry green pepper 60g, red Sugared 207g, then 1244g water is poured into, sealed fermenter, controlling the temperature in fermentor is 39 DEG C, is fermented 3 months；
S2, in steeping tank be added zaocys dhumnade 45g, centipede 20g, scorpio 48g, ground bettle 45g, leech 13g, earthworm 20g, Honeycomb 45g, then 62 ° of white wine 2873.5g is poured into, sealed soak tank, controlling the temperature in steeping tank is 39 DEG C, is impregnated 3 months；
S3, solid medicinal material in fermentor and steeping tank is discarded, taken in the fermentation liquid 1kg and steeping tank in fermentor Extracting solution 1.5kg mixing, under room temperature item, the external application Chinese medicine agent to get treatment of arthritis in 1 month is placed in sealing.
Embodiment 4
A kind of external application Chinese medicine agent for the treatment of of arthritis, including the first component and the second component；
First component includes the component of following mass fraction:
Common St.Paulswort Herb 160g；Aconiti preparata,radix 20g；Monkshood 15g；Radix Glycyrrhizae 17g；Safflower 35g；Caulis sinomenii 35g；Caulis trachelospermi 60g；Heath Rattan 62g；Rhizoma dioscoreae nipponicae 53g；Radix achyranthis bidentatae 15g；Ramulus cinnamomi 45g；Herba taxilli 50g；Ginger 21g；Dry green pepper 63g；Water 814g；Brown sugar 163g；
Second component includes the component of following mass fraction:
Zaocys dhumnade 52g；Centipede 20g；Scorpio 53g；Ground bettle 45g；Leech 15g；Earthworm 23g；Honeycomb 52g；White wine 1368g。
The external application Chinese medicine agent for the treatment of of arthritis the preparation method is as follows:
S1, in the fermenter Jia Ru Common St.Paulswort Herb 160g, aconiti preparata,radix 20g, monkshood 15g, Radix Glycyrrhizae 17g, safflower 35g, caulis sinomenii It is 35g, caulis trachelospermi 60g, Caulis et Folium piperis 62g, rhizoma dioscoreae nipponicae 53g, radix achyranthis bidentatae 15g, ramulus cinnamomi 45g, herba taxilli 50g, ginger 21g, dry green pepper 63g, red Sugared 163g, then 814g water is poured into, sealed fermenter, controlling the temperature in fermentor is 41 DEG C, is fermented 3 months；
S2, in steeping tank be added zaocys dhumnade 52g, centipede 20g, scorpio 53g, ground bettle 45g, leech 15g, earthworm 23g, Honeycomb 52g, then 63 ° of white wine 1368g is poured into, sealed soak tank, controlling the temperature in steeping tank is 41 DEG C, is impregnated 3 months；
S3, solid medicinal material in fermentor and steeping tank is discarded, taken in the fermentation liquid 1kg and steeping tank in fermentor Extracting solution 1kg mixing, under room temperature item, the external application Chinese medicine agent to get treatment of arthritis in 1 month is placed in sealing.
Embodiment 5
A kind of external application Chinese medicine agent for the treatment of of arthritis, including the first component and the second component；
First component includes the component of following mass fraction:
Common St.Paulswort Herb 150g；Aconiti preparata,radix 15g；Monkshood 15g；Radix Glycyrrhizae 15g；Safflower 30g；Caulis sinomenii 30g；Caulis trachelospermi 60g；Heath Rattan 60g；Rhizoma dioscoreae nipponicae 45g；Radix achyranthis bidentatae 15g；Ramulus cinnamomi 45g；Herba taxilli 50g；Ginger 21g；Dry green pepper 63g；Water 1842g；Brown sugar 614g；
Second component includes the component of following mass fraction:
Zaocys dhumnade 52g；Centipede 20g；Scorpio 53g；Ground bettle 45g；Leech 15g；Earthworm 23g；Honeycomb 52g；White wine 2810g。
The external application Chinese medicine agent for the treatment of of arthritis the preparation method is as follows:
S1, in the fermenter Jia Ru Common St.Paulswort Herb 150g, aconiti preparata,radix 15g, monkshood 15g, Radix Glycyrrhizae 15g, safflower 30g, caulis sinomenii It is 30g, caulis trachelospermi 60g, Caulis et Folium piperis 60g, rhizoma dioscoreae nipponicae 45g, radix achyranthis bidentatae 15g, ramulus cinnamomi 45g, herba taxilli 50g, ginger 21g, dry green pepper 63g, red Sugared 614g, then 1842g water is poured into, sealed fermenter, controlling the temperature in fermentor is 45 DEG C, is fermented 3 months；
S2, in steeping tank be added zaocys dhumnade 52g, centipede 20g, scorpio 53g, ground bettle 45g, leech 15g, earthworm 23g, Honeycomb 52g, then 65 ° of white wine 2810g is poured into, sealed soak tank, controlling the temperature in steeping tank is 45 DEG C, is impregnated 3 months；
S3, solid medicinal material in fermentor and steeping tank is discarded, taken in the fermentation liquid 1kg and steeping tank in fermentor Extracting solution 1kg mixing, under room temperature item, the external application Chinese medicine agent to get treatment of arthritis in 1 month is placed in sealing.
Comparative example 1
A kind of external application Chinese medicine agent for the treatment of of arthritis, including the first component and the second component；
First component includes the component of following mass fraction:
Common St.Paulswort Herb 150g；Aconiti preparata,radix 15g；Monkshood 15g；Radix Glycyrrhizae 15g；Safflower 30g；Caulis sinomenii 30g；Caulis trachelospermi 60g；Heath Rattan 60g；Rhizoma dioscoreae nipponicae 45g；Radix achyranthis bidentatae 15g；Ramulus cinnamomi 45g；Herba taxilli 50g；Ginger 21g；Dry green pepper 63g；Water 1228g；Brown sugar 205g；
Second component includes the component of following mass fraction:
Zaocys dhumnade 52g；Centipede 20g；Scorpio 53g；Ground bettle 45g；Leech 15g；Earthworm 23g；Honeycomb 52g；White wine 763.5g。
The external application Chinese medicine agent for the treatment of of arthritis the preparation method is as follows:
S1, in the fermenter Jia Ru Common St.Paulswort Herb 150g, aconiti preparata,radix 15g, monkshood 15g, Radix Glycyrrhizae 15g, safflower 30g, caulis sinomenii It is 30g, caulis trachelospermi 60g, Caulis et Folium piperis 60g, rhizoma dioscoreae nipponicae 45g, radix achyranthis bidentatae 15g, ramulus cinnamomi 45g, herba taxilli 50g, ginger 21g, dry green pepper 63g, red Sugared 205g, then g water is poured into, sealed fermenter, controlling the temperature in fermentor is 45 DEG C, is fermented 3 months；
S2, in steeping tank be added zaocys dhumnade 52g, centipede 20g, scorpio 53g, ground bettle 45g, leech 15g, earthworm 23g, Honeycomb 52g, then 64 ° of white wine 763.5g is poured into, sealed soak tank, it is 45 DEG C that the temperature in steeping tank is sent out in control, impregnates 3 Month；
S3, solid medicinal material in fermentor and steeping tank is discarded, taken in the fermentation liquid 1kg and steeping tank in fermentor Extracting solution 1kg mixing, under room temperature item, the external application Chinese medicine agent to get treatment of arthritis in 1 month is placed in sealing.
Comparative example 2
A kind of external application Chinese medicine agent for the treatment of of arthritis, including the first component and the second component；
First component includes the component of following mass fraction:
Common St.Paulswort Herb 150g；Aconiti preparata,radix 15g；Monkshood 15g；Radix Glycyrrhizae 15g；Safflower 30g；Caulis sinomenii 30g；Caulis trachelospermi 60g；Heath Rattan 60g；Rhizoma dioscoreae nipponicae 45g；Radix achyranthis bidentatae 15g；Ramulus cinnamomi 45g；Herba taxilli 50g；Ginger 21g；Dry green pepper 63g；Water 1228g；Brown sugar 205g；
Second component includes the component of following mass fraction:
Zaocys dhumnade 52g；Centipede 20g；Scorpio 53g；Ground bettle 45g；Leech 15g；Earthworm 23g；Honeycomb 52g；White wine 3834g。
The external application Chinese medicine agent for the treatment of of arthritis the preparation method is as follows:
S1, in the fermenter Jia Ru Common St.Paulswort Herb 150g, aconiti preparata,radix 15g, monkshood 15g, Radix Glycyrrhizae 15g, safflower 30g, caulis sinomenii It is 30g, caulis trachelospermi 60g, Caulis et Folium piperis 60g, rhizoma dioscoreae nipponicae 45g, radix achyranthis bidentatae 15g, ramulus cinnamomi 45g, herba taxilli 50g, ginger 21g, dry green pepper 63g, red Sugared 205g, then 1228g water is poured into, sealed fermenter, controlling the temperature in fermentor is 45 DEG C, is fermented 3 months；
S2, in steeping tank be added zaocys dhumnade 52g, centipede 20g, scorpio 53g, ground bettle 45g, leech 15g, earthworm 23g, Honeycomb 52g, then 64 ° of white wine 3834g is poured into, sealed soak tank, controlling the temperature in steeping tank is 45 DEG C, is impregnated 3 months；
S3, solid medicinal material in fermentor and steeping tank is discarded, taken in the fermentation liquid 1kg and steeping tank in fermentor Extracting solution 1kg mixing, under room temperature item, the external application Chinese medicine agent to get treatment of arthritis in 1 month is placed in sealing.
Comparative example 3
A kind of external application Chinese medicine agent for the treatment of of arthritis, the component including following mass fraction:
Zaocys dhumnade 15g；Lion tail 20g；Pheretima 10g；Radix Angelicae Sinensis 5g；Radix Astragali 30g；Centipede 5g；Rhizoma dioscoreae nipponicae 20g；Bailey Myospalax Born 16g；Asarum 5g；Brewing grains white spirit 300g.
The external application Chinese medicine agent for the treatment of of arthritis the preparation method is as follows:
S1, stock: prepare the material medicine of following parts by weight meter: zaocys dhumnade 15g, lion tail 20g, pheretima 10g, Radix Angelicae Sinensis 5g, Radix Astragali 30g, centipede 5g, rhizoma dioscoreae nipponicae 20g, Bailey Myospalax Born 16g, asarum 5g, brewing grains white spirit 300g；
S2, encapsulation are brewed: the solid component in above-mentioned Chinese medicine material being fitted into container jointly, it is white to be subsequently poured into pure grain Wine impregnates 6-7 days, and at least stirring is primary daily, stirs 10-15 minutes every time so that white wine fully absorb drug it is effective at Point, closed preservation after having stirred；
S3, filtering: it is separated by filtration the external application Chinese medicine agent up to treatment of arthritis.
Experiment 1
100 patients are extracted, above embodiments is smeared in the arthritis sore spot of patient and comparative example prepares resulting medicine Agent generates heat after smearing 20min, records the arthralgia index of patient, and record patient and adhere to using the arthralgia after half a year Situation and recurrence rate (%).
The criterion of arthralgia index are as follows: without pain is 0 point；Mild pain can be endured, and releiving without medication is 1 Point；Severe pain, can not be releived using drug is 3 points.
Each embodiment and the detection data of comparative example are shown in Table 1.
Table 1
Can be obtained according to the data comparison of embodiment 1-3 in table 1, in the first component in embodiment 1-3 water removal and brown sugar with The summation and water of other outer each components and the mass parts ratio of brown sugar are 3:6:1, the first component and second in embodiment 1 The ratio of component is 1:1, and the ratio of the first component and the second component in embodiment 2 is 1:1.3, first group in embodiment 3 Dividing with the ratio of the second component is 1:1.5, and curative effect is better with embodiment 3 than embodiment 2 for the curative effect of embodiment 1, recurrence rate It is lower, illustrate through the ratio of the first component of control and the second component to be 1:1, is conducive to the drug effect for improving medicament, so that medicament It takes effect faster, therapeutic effect is more preferable, it is not easy to recur.
It can be obtained according to the data comparison of embodiment 1 in table 1, embodiment 4-5, embodiment 1, embodiment 4 and embodiment 5 The ratio of first component and the second component is 1:1, removed water in embodiment 1 and brown sugar other than other each components summation and water It is 3:6:1 with the mass parts ratio of brown sugar, the summation and water and brown sugar of other each components in embodiment 4 other than water removal and brown sugar Mass parts ratio be 4:5:1, the summation of other each components in embodiment 5 other than water removal and brown sugar and the quality of water and brown sugar Portion rate is 2:6:2, and the curative effect of embodiment 1 is more preferable than embodiment 4 and the curative effect of embodiment 5, and recurrence rate is lower, is illustrated logical The summation and water of other each components crossed other than control water removal and brown sugar and the mass parts ratio of brown sugar are 3:6:1, are conducive to mention The drug effect of high medicament, so that medicament takes effect faster, therapeutic effect is more preferable, it is not easy to recur.
It can be obtained according to the data comparison of embodiment 1-5 in table 1 and comparative example 1-2, be removed water in comparative example 1 and comparative example 2 It is 3:6:1 with the summation and water of other each components other than brown sugar and the mass parts ratio of brown sugar, first group in comparative example 1 Dividing with the ratio of the second component is 1:0.5, and the ratio of the first component and the second component in comparative example 2 is 1:2, and comparative example 1 Difference with the therapeutic effect of comparative example 2 than embodiment 1-5, illustrating mainly to rise improve pharmacodynamic feature is the first component and second The ratio of component illustrates through the ratio of the first component of control and the second component to be 1:1, is conducive to the drug effect for improving medicament, makes It obtains medicament to take effect faster, therapeutic effect is more preferable, it is not easy to recur.
It can be obtained according to the data comparison of embodiment 1-5 in table 1 and comparative example 3, embodiment 1-5 is using the ingredient in the present invention Proportion prepares medicament, and comparative example 3 prepares medicament using existing ingredient proportion, and the drug effect of embodiment 1-5 is more equal than comparative example 3 More preferably, illustrate that curative effect of medicine is more preferable, takes effect more using the external application Chinese medicine agent of ingredient proportion preparation treatment of arthritis of the invention Fastly, uneasy to recur.
The embodiment of present embodiment is presently preferred embodiments of the present invention, not limits protection of the invention according to this Range, therefore: the equivalence changes that all structures under this invention, shape, principle are done, should all be covered by protection scope of the present invention it It is interior.

Claims (9)

1. the external application Chinese medicine agent of a kind for the treatment of of arthritis, it is characterized in that: including the first component and the second component, first component Mass parts ratio with the second component is 1:1-1.5；
First component includes 120-160 parts of the component: Common St.Paulswort Herb of following mass fraction；10-20 parts of aconiti preparata,radix；Monkshood 10- 15 parts；10-17 parts of Radix Glycyrrhizae；30-35 parts of safflower；25-35 parts of caulis sinomenii；50-60 parts of caulis trachelospermi；55-62 parts of Caulis et Folium piperis；Rhizoma dioscoreae nipponicae 45-53 parts；10-15 parts of radix achyranthis bidentatae；40-45 parts of ramulus cinnamomi；42-50 parts of herba taxilli；15-21 parts of ginger；Dry green pepper 55-63 parts, remaining is water And brown sugar；
Second component includes the component of following mass fraction: 40-52 parts of zaocys dhumnade；15-20 parts of centipede；40-53 parts of scorpio； 40-45 parts of ground bettle；10-15 parts of leech；15-23 parts of earthworm；40-52 parts of honeycomb, remaining is white wine.
2. the external application Chinese medicine agent of a kind for the treatment of of arthritis according to claim 1, it is characterized in that: first component includes 145-155 parts of the component: Common St.Paulswort Herb of following mass fraction；13-15 parts of aconiti preparata,radix；14-15 parts of monkshood；13-16 parts of Radix Glycyrrhizae；Safflower 30-32 parts；28-32 parts of caulis sinomenii；54-60 parts of caulis trachelospermi；58-61 parts of Caulis et Folium piperis；45-50 parts of rhizoma dioscoreae nipponicae；13-15 parts of radix achyranthis bidentatae； 43-45 parts of ramulus cinnamomi；42-45 parts of herba taxilli；18-21 parts of ginger；Dry green pepper 58-60 parts, remaining is water and brown sugar；
Second component includes the component of following mass fraction: 40-45 parts of zaocys dhumnade；18-20 parts of centipede；40-48 parts of scorpio； 43-45 parts of ground bettle；10-13 parts of leech；15-20 parts of earthworm；40-45 parts of honeycomb, remaining is white wine.
3. the external application Chinese medicine agent of a kind for the treatment of of arthritis according to claim 1 to 2, it is characterized in that: described first group Dividing with the mass parts ratio of the second component is 1:1.
4. the external application Chinese medicine agent of a kind for the treatment of of arthritis according to claim 1 to 2, it is characterized in that: the arthritis External application Chinese medicine agent preparation method the following steps are included:
S1, water removal in the first component and other each components other than brown sugar are put into fermentor in mass fraction ratio, then plus Water and brown sugar ferment 3 months；
S2, other each components in the second component in addition to white wine are put into steeping tank in mass fraction ratio, then plus white wine It impregnates 3 months；
S3, will be impregnated in ferment in S1 resulting liquid and S2 resulting liquid in mass parts ratio be 1:1-1.5 ratio mix It closes, places one month.
5. the external application Chinese medicine agent of a kind for the treatment of of arthritis according to claim 4, it is characterized in that: being removed in first component The summation and water of other each components other than water and brown sugar and the mass parts ratio of brown sugar are 3:6:1.
6. the external application Chinese medicine agent of a kind for the treatment of of arthritis according to claim 4, it is characterized in that: the step S1 and step In S2, fermentation and the temperature impregnated are controlled at 35 DEG C -45 DEG C.
7. the external application Chinese medicine agent of a kind for the treatment of of arthritis according to claim 4, it is characterized in that: being used in the step S2 In immersion white wine degree be 60 ° -65 °.
8. the external application Chinese medicine agent of a kind for the treatment of of arthritis according to claim 7, it is characterized in that: being used in the step S2 In immersion white wine degree be 60 °.
9. the external application Chinese medicine agent of a kind for the treatment of of arthritis according to claim 4, it is characterized in that: being used in the step S2 In immersion white wine be liquor made from sorghum.
CN201910106407.5A 2019-02-02 2019-02-02 A kind of external application Chinese medicine agent for the treatment of of arthritis Pending CN109568561A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103830277A (en) * 2012-11-22 2014-06-04 马东升 Traditional Chinese medicine scorpion/zaocys dhumnade/centipede/Eupolyphaga/lumbricus wine for treating rheumatic arthritis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103830277A (en) * 2012-11-22 2014-06-04 马东升 Traditional Chinese medicine scorpion/zaocys dhumnade/centipede/Eupolyphaga/lumbricus wine for treating rheumatic arthritis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
作者无: "风湿止痛药酒", 《医学百科网》 *
唐瑛等: "中药复方敷擦外治类风湿性关节炎的用药规律研究", 《西部中医药》 *
郭齐等: "中医治疗类风湿性关节炎组方配伍规律探析", 《中国中医基础医学杂志》 *

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RJ01 Rejection of invention patent application after publication

Application publication date: 20190405

RJ01 Rejection of invention patent application after publication