CN109568282A - A kind of cud sustained-release tablet and preparation method containing acetylamino evericin - Google Patents
A kind of cud sustained-release tablet and preparation method containing acetylamino evericin Download PDFInfo
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- CN109568282A CN109568282A CN201811622230.6A CN201811622230A CN109568282A CN 109568282 A CN109568282 A CN 109568282A CN 201811622230 A CN201811622230 A CN 201811622230A CN 109568282 A CN109568282 A CN 109568282A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
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- Tropical Medicine & Parasitology (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A kind of cud sustained-release tablet containing acetylamino evericin, it is characterized by: the cud sustained-release tablet includes the component of following mass fraction: acetylamino evericin 0.5-20%, bulk erosion agent 1-5%, specific gravity regulator 10-70%, adhesive 1-20%, lubricant 0.1-1%, antioxidant 0.05-1.0%, filler 5-50%；The sum of mass percent of above-mentioned raw materials is 100%.The present invention is prepared using direct compression method, solves the complexity of production technology existing for conventional cud sustained release preparation, high expensive, the disadvantages of metal device of medicine-releasing system cannot take out, and medication effect is significantly improved, continuous drug release time was up to 90 days in cud for drug, and drug noresidue in milk increases the safety of cattle and sheep deep-processed food.
Description
Technical field
The present invention relates to a kind of cud sustained-release tablet and preparation method thereof containing acetylamino evericin, belongs to veterinary drug skill
Art field.
Background technique
In aquaculture, parasitic disease is the common disease of domestic animal.Due to the domestic animals such as ox, sheep daily with helminth cause of disease frequency
Numerous contact, greatly increases probability of illness.Helminth consumes Animal nutrition, increases aquaculture cost, reduces the price of deed, reduces life
Performance is produced, caused economic loss is often slow, recessive, huge.Each domestic animal has helminth parasitic, works as polypide
When infective dose is few, carcass is not fallen ill, but milk, meat, Wool yield can be made to reduce, and constitution decline, trunk and internal organ are discarded when butchering,
Other secondary viruses or bacteriosis etc. when weak.When polypide infective dose is larger, livestock nutrition is extremely low, can also cause
Large quantities of death.It is the main technique methods of current animal parasite disease prevention and treatment using the regular expelling parasite of chemicals.But due to family
Raise parasitic disease especially cattle and sheep Biocontrol of Gastrointestinal Nematodes have repeatedly, the characteristic of persistent infection, the control efficiency to have obtained,
It must repeated multiple times dispensing.Therefore, the controlled and sustained release preparation technique of development of new antiparasitic agent can significantly improve milk cow and support
The economic benefit grown.
Acetylamino evericin is a kind of macrolide antibiotics of the exploitation of Merck company, the U.S. in 1996, mainly
The nervous system of helminth is acted on, promotes γ-aminobutyric acid release, opens chloride channel, the excitement to muscle is prevented to pass
It passs, finally makes helminth paralysis lethal, have very strong killing effect to most nematodes and insect.It answers currently on the market
It is ivermectin with more broad-spectrum anti-parasite medicine, but its milk/blood system distribution coefficient is higher (1.1), is applied to lactation period milk
Ox needs discarded 35 days milk；28 days off-drug periods are needed applied to beef cattle.And acetylamino evericin milk/blood system is matched
Coefficient is low (0.17), is the currently the only broad-spectrum anti-parasite medicine that can be applied to all oxen and be not required to the off-drug period.
Currently, acetylamino evericin preparation is mainly pre-mixing agent, dashing agent and injection in the market, these dosage forms are equal
Belong to regular dosage form, the effective blood drug concentration duration is short, needs multiple dosing that can reach preferable control efficiency, is unfavorable for herding
The intensive culture of industry.Therefore, the long-acting dosage form for developing a kind of acetylamino evericin guarantees that it reaches in targeted tissue
Effective concentration simultaneously maintains the sufficiently long time very necessary.Such as ox, sheep cud sustained release preparation, curative effect of medication can be improved, subtract
Few times for spraying makes drug effect maintain the long period, prevent parasitic disease repeatedly, persistent infection, be to effectively prevent helminth
One of the important means of disease；In addition, cud sustained release agent specific gravity needs especially control, after guaranteeing medication, sustained release agent sinks to cattle and sheep
Stomach bottom, is not ruminated out, guarantees the sustained release of drug.
Summary of the invention
The present invention is directed to prior art problem, provides a kind of cud sustained-release tablet and its system containing acetylamino evericin
Preparation Method, the present invention are prepared using direct compression method, solve the complexity of production technology existing for conventional cud sustained release preparation,
The disadvantages of high expensive, the metal device of medicine-releasing system cannot take out, and medication effect is significantly improved, drug
Continuous drug release time was up to 90 days in cud, and drug noresidue in milk, increased the safety of cattle and sheep deep-processed food.
Technical problem of the present invention is solved with following technical solution:
A kind of cud sustained-release tablet containing acetylamino evericin, the cud sustained-release tablet include the group of following mass fraction
Point: acetylamino evericin 0.5-20%, bulk erosion agent 1-5%, specific gravity regulator 10-70%, adhesive 1-20%, lubricant
0.1-1%, antioxidant 0.05-1.0%, filler 5-50%；The sum of mass percent of above-mentioned raw materials is 100%.
The above-mentioned cud sustained-release tablet containing acetylamino evericin, the bulk erosion agent are cellulose and its derivative
One of object, polyvinyl alcohol, polyacrylic resin, high-grade aliphatic ester, higher aliphatic alcohol ester and hydrogenated vegetable oils are more
Kind.
The above-mentioned cud sustained-release tablet containing acetylamino evericin, affiliated specific gravity regulator are iron powder, copper powder, barite
One of powder, magnesia powder and heavy mountain flour are a variety of.
The above-mentioned cud sustained-release tablet containing acetylamino evericin, described adhesive are sodium carboxymethylcellulose, hydroxypropyl
One of ylmethyl cellulose and Arabic gum are a variety of.
The above-mentioned cud sustained-release tablet containing acetylamino evericin, the lubricant is magnesium stearate, zinc stearate, hard
One or more of resin acid aluminium and talcum powder.
The above-mentioned cud sustained-release tablet containing acetylamino evericin, the antioxidant are sodium hydrogensulfite, lay particular stress on Asia
One or both of sodium sulphate, sodium thiosulfate, Butylated Hydroxytoluene and propylgallate.
The above-mentioned cud sustained-release tablet containing acetylamino evericin, the filler are starch, dextrin, microcrystalline cellulose
One or both of element, Icing Sugar and calcium sulfate.
A kind of preparation method of the cud sustained-release tablet containing acetylamino evericin, includes the following steps:
A, the acetylamino evericin of formula ratio, antioxidant and bulk erosion agent are added to stirring and dissolving in wetting agent,
It is spare；
B, specific gravity regulator, filler and the adhesive of formula ratio are put into mixing machine and are uniformly mixed, then by the step a
The solution of preparation is added in mixing machine, is stirred evenly, and softwood is made；
C, the softwood of the step b preparation is pelletized through granulator, is then transferred in dryer, is dried, whole grain after drying, whole grain
The mix lubricant that formula ratio is added afterwards is uniform, obtains particle；
D, particle obtained by the step c is subjected to tabletting through one-shot strength tablet press machine, obtains cud sustained-release tablet.
The preparation method of the above-mentioned cud sustained-release tablet containing acetylamino evericin, the wetting agent in the step a are used
Amount is the 10-30% of the cud sustained-release tablet quality, and the wetting agent is one or both of water and ethyl alcohol.
The present invention, for main anthelmintic ingredient, and is used in compounding bulk erosion agent, adhesive etc. with acetylamino evericin
Ingredient prepares cud sustained release tablets using the method for strength tabletting using single-punch tablet press, tablet specific gravity is made to reach 2.5-3.0, mouth
Tablet is heavy after clothes stays in cud or reticulum bottom, will not be ruminated out by animal；Cud sustained-release tablet of the present invention is in cattle and sheep cud
In, it is slowly dissolved sustained-release matrix (bulk erosion agent) day by day and releases acetylamino
Avermectin anthelmintic drug plays effect into cud or reticulum by controlling rate of release (solubility) slow release drug
, controlled release is achieved the effect that by corroding for sustained-release matrix.Said preparation drug release time is long, can extended stationary periods discharged in cud
Anthelmintic drug, and constant blood concentration is maintained in vivo, avoid ill domestic animal from generating blood concentration because of frequent drug administration during treatment
" peak valley " phenomenon-take the photograph medicine uneven phenomenon.Cud sustained release tablets have the advantages that general preparation is no, can make after single administration
Animal is not in the entire production cycle by the infection of helminth, and convenient drug administration, bioavilability is high, can replace existing conventional agent
Type.
The preparation method of cud sustained-release tablet of the present invention is simple, effective, solves general cud preparation production technique complexity,
High expensive, and the disadvantages of the metal device of medicine-releasing system cannot take out, it is suitble to industrialized production, and production technology meets
GMP requirement.And drug continuous drug release time in cud is up to 90 days, and drug noresidue in milk, increases cattle and sheep etc.
The safety of domestic animal deep-processed food.
Specific embodiment
Cud sustained-release tablet of the present invention containing acetylamino evericin is the tablet of 19-50g/ piece, specific gravity 2.5-
3.0, stability test is carried out to it.
1, long-time stability
When long-time stability refer to that cud sustained release tablets are stored at room temperature, every physical and chemical parameter extends at any time and becomes
The degree of change.After stability test in 24 months, the items physical and chemical parameter such as appearance and content meets the requirements this cud sustained release tablets,
The indexs such as dissolution rate illustrate that long-time stability are good there is no variation.
2, heat storage stability
Cud sustained release tablets are sealed, is placed in 54 DEG C of insulating boxs and stores 14 days, the items physical and chemical parameter such as appearance and content meets
It is required that the indexs such as dissolution rate, there is no variation, content detection degrades in 5% range, meets the requirements.
3, light durability
The sealing sealing of cud sustained release tablets is placed under 1500 ± 500LX, light at room temperature shines 10d, samples in 1d, 3d, 5d, 10d.Knot
Fruit shows that every physical and chemical parameter such as this cud sustained release tablets appearance and content meets the requirements, and there is no becoming for the indexs such as dissolution rate
Change, shows that photostability is good.
The invention will be further described with reference to embodiments.
Embodiment 1
Cud sustained-release tablet containing acetylamino evericin includes the component of following mass fraction: acetylamino evericin
4%, blanc fixe 40%, ethyl cellulose 3%, sodium carboxymethylcellulose 5%, magnesium stearate 0.5%, Butylated Hydroxytoluene 0.1%,
Icing Sugar 47.4%.
Preparation process are as follows: a, the acetylamino evericin, Butylated Hydroxytoluene and ethyl cellulose of formula ratio are added
The stirring and dissolving in ethyl alcohol (ethanol consumption is the 10% of said components gross mass), it is spare；
B, the blanc fixe of formula ratio, Icing Sugar and sodium carboxymethylcellulose are put into mixing machine and are uniformly mixed, it then will be described
The solution of step a preparation is added in mixing machine, is stirred evenly, and softwood is made；
C, the softwood of the step b preparation is pelletized through granulator, is then transferred in dryer, is dried, whole grain after drying, whole grain
The magnesium stearate that formula ratio is added afterwards is uniformly mixed, and obtains particle；
D, particle obtained by the step c is subjected to tabletting through one-shot strength tablet press machine, obtains cud sustained-release tablet.
Embodiment 2
Cud sustained-release tablet containing acetylamino evericin includes the component of following mass fraction: acetylamino evericin
4%, magnesia powder 50%, ethyl cellulose 5%, sodium carboxymethylcellulose 10%, magnesium stearate 0.5%, propylgallate 0.2%,
Icing Sugar 30.3%.
Preparation process are as follows: a, the acetylamino evericin, propylgallate and ethyl cellulose of formula ratio are added
The stirring and dissolving in ethyl alcohol (ethanol consumption is the 10% of said components gross mass), it is spare；
B, the magnesia powder of formula ratio, Icing Sugar and sodium carboxymethylcellulose are put into mixing machine and are uniformly mixed, it then will be described
The solution of step a preparation is added in mixing machine, is stirred evenly, and softwood is made；
C, the softwood of the step b preparation is pelletized through granulator, is then transferred in dryer, is dried, whole grain after drying, whole grain
The magnesium stearate that formula ratio is added afterwards is uniformly mixed, and obtains particle；
D, particle obtained by the step c is subjected to tabletting through one-shot strength tablet press machine, obtains cud sustained-release tablet.
Embodiment 3
Cud sustained-release tablet containing acetylamino evericin includes the component of following mass fraction: acetylamino evericin
10%, blanc fixe 60%, polyvinyl alcohol 3%, hydroxypropyl methyl cellulose 10%, magnesium stearate 0.5%, propylgallate 0.2%,
Calcium sulfate 16.3%.
Preparation process are as follows: a, be added to the acetylamino evericin, propylgallate and polyvinyl alcohol of formula ratio
Stirring and dissolving in ethyl alcohol (ethanol consumption is the 10% of said components gross mass), it is spare；
B, the blanc fixe of formula ratio, calcium sulfate and hydroxypropyl methyl cellulose are put into mixing machine and are uniformly mixed, then will
The solution of the step a preparation is added in mixing machine, stirs evenly, softwood is made；
C, the softwood of the step b preparation is pelletized through granulator, is then transferred in dryer, is dried, whole grain after drying, whole grain
The magnesium stearate that formula ratio is added afterwards is uniformly mixed, and obtains particle；
D, particle obtained by the step c is subjected to tabletting through one-shot strength tablet press machine, obtains cud sustained-release tablet.
Embodiment 4
Cud sustained-release tablet containing acetylamino evericin includes the component of following mass fraction: acetylamino evericin
10%, iron powder 50%, polyacrylic resin 3%, Arabic gum 10%, talcum powder 0.5%, propylgallate 0.5%, Icing Sugar 26%.
Preparation process: a, the acetylamino evericin, propylgallate and polyacrylic resin of formula ratio are added
The stirring and dissolving in ethyl alcohol (ethanol consumption is the 10% of said components gross mass), it is spare；
B, the iron powder of formula ratio, Icing Sugar and Arabic gum are put into mixing machine and are uniformly mixed, then by step a preparation
Solution is added in mixing machine, is stirred evenly, and softwood is made；
C, the softwood of the step b preparation is pelletized through granulator, is then transferred in dryer, is dried, whole grain after drying, whole grain
The talcum powder that formula ratio is added afterwards is uniformly mixed, and obtains particle；
D, particle obtained by the step c is subjected to tabletting through one-shot strength tablet press machine, obtains cud sustained-release tablet.
Embodiment 5
Cud sustained-release tablet containing acetylamino evericin includes the component of following mass fraction: acetylamino evericin
10%, iron powder 50%, ethyl cellulose 5%, hydroxypropyl methyl cellulose 15%, talcum powder 1%, propylgallate 1%, Icing Sugar
18%。
Preparation process: a, the acetylamino evericin, propylgallate and ethyl cellulose of formula ratio are added to
Stirring and dissolving in ethyl alcohol (ethanol consumption is the 10% of said components gross mass), it is spare；
B, the iron powder of formula ratio, Icing Sugar and hydroxypropyl methyl cellulose are put into mixing machine and are uniformly mixed, then by the step
The solution of rapid a preparation is added in mixing machine, stirs evenly, softwood is made；
C, the softwood of the step b preparation is pelletized through granulator, is then transferred in dryer, is dried, whole grain after drying, whole grain
The talcum powder that formula ratio is added afterwards is uniformly mixed, and obtains particle；
D, particle obtained by the step c is subjected to tabletting through one-shot strength tablet press machine, obtains cud sustained-release tablet.Effect experiment
(1) pharmacodynamic test is carried out to epizoa in prevention Contents in Cows to cud sustained-release tablet of the present invention:
Test milk cow: test is carried out in Hebei Shijiazhuang cattle farm, and kind is holstein cow, and totally 80.It is randomly divided into sky
White control group and two groups of sustained release tablets group of the present invention, every group 40.
Test daily ration composition: test group and blank control group use same feeding and management method.Diet group becomes fine fodder,
Coarse fodder is corn silage.
Test method: blank control group is without using cud sustained-release tablet of the invention, also without using other anthelmintics；Test
Group uses cud sustained-release tablet of the invention, application method: according to requirements, every ox, each one, 90 days pre- for one
The anti-period；A situation arises for epizoa in observation, record test group and control group Contents in Cows during test, as a result such as table 1.
Test period: June in experimental period from 20 days -2016 March in 2015 18 end of day, last 90 days.
Ectoparasite disease control effect in 1 Contents in Cows of table
| Group | Total head number | It falls ill number (head) | Disease incidence |
| Control group | 40 | 13 | 32.5% |
| This sustained release tablets group | 40 | 2 | 5.0% |
By table 1, it can be concluded that, cud sustained release tablets of the present invention can effectively prevent the generation of ectoparasite disease in Contents in Cows, especially to line
There is preferable control efficiency to have many advantages, such as nontoxic, noresidue compared with other anthelmintics for parasitosis, body surface acariasis etc..
(2) expelling parasite cud sustained release tablets of the present invention treat Contents in Cows acariasis pharmacodynamic test
Test material: expelling parasite sustained release tablets, commercially available Doramectin injection fluid and ivermectin injection prepared by the present invention.
Test milk cow: test Hebei Shijiazhuang cattle farm carry out, totally 90 with degree of approximation acarid disease lotus this
Smooth milk cow.It is randomly divided into control group and test group, control group test group is divided into Doramectin injection fluid group, ivermectin injection
Group, test group be sustained release tablets group of the present invention, every group 30.
Test daily ration composition: test group and control group use same feeding and management method.Diet group becomes fine fodder, coarse fodder
For corn silage.
Test method: test group and control group treat acarid disease respectively, application method: are made according to respective operation instruction
With a drug treats a course for the treatment of.
Curative effect determinate standard: infected cattle symptom is observed after the 7th day, 14 days and treatment end 60 days after medication, according to judgement
Standard determines curative effect.Suffer from ox wound healing to cure；Itch is substantially reduced, surface of a wound range shorter, rub itch be reduced to effectively；Itch
It does not disappear, the surface of a wound is invalid without recession.Total effectively head number is equal to recovery from illness and effective head number summation.
Statistics and analysis is carried out to the result for the treatment of, specific as shown in Table 2-4:
Table 2 medication, 7 days treatment results
| Group | It falls ill number (head) | It cures number (head) | Significant figure (head) | Invalid number (head) | It is efficient |
| Doractin group | 30 | 27 | 2 | 1 | 96.7% |
| Ivermectin group | 30 | 23 | 4 | 3 | 90.0% |
| This sustained release tablets group | 30 | 25 | 3 | 2 | 93.3% |
Table 3 medication, 14 days treatment results
| Group | It falls ill number (head) | It cures number (head) | Significant figure (head) | Invalid number (head) | It is efficient |
| Doractin group | 30 | 29 | 1 | 0 | 100.0% |
| Ivermectin group | 30 | 27 | 2 | 1 | 96.7% |
| This sustained release tablets group | 30 | 28 | 2 | 0 | 100.0% |
4 medication of table terminates treatment results after 60 days
| Group | Milk cow (head) | It falls ill number (head) | Disease incidence |
| Doractin group | 30 | 13 | 43.3% |
| Ivermectin group | 30 | 15 | 50.0% |
| This sustained release tablets group | 30 | 1 | 3.3% |
Expelling parasite cud sustained release tablets of the present invention can quickly, effectively treat epizoa in Contents in Cows it can be seen from table 2-4 result
Disease, duration of efficacy is longer compared with other anthelmintics, compares other anthelmintics, does not remain in milk, improves milk cow
The foodsafety of deep processed product.
Claims (9)
1. a kind of cud sustained-release tablet containing acetylamino evericin, it is characterised in that: the cud sustained-release tablet includes such as
The component of lower mass fraction: acetylamino evericin 0.5-20%, bulk erosion agent 1-5%, specific gravity regulator 10-70%, bonding
Agent 1-20%, lubricant 0.1-1%, antioxidant 0.05-1.0%, filler 5-50%；The sum of mass percent of above-mentioned raw materials is
100%。
2. the cud sustained-release tablet according to claim 1 containing acetylamino evericin, it is characterised in that: the skeleton
Corrosion agent is cellulose and its derivates, polyvinyl alcohol, polyacrylic resin, high-grade aliphatic ester, higher aliphatic alcohol ester and hydrogen
Change one of plant oil or a variety of.
3. the cud sustained-release tablet according to claim 2 containing acetylamino evericin, it is characterised in that: affiliated specific gravity
Regulator is one of iron powder, copper powder, blanc fixe, magnesia powder and heavy mountain flour or a variety of.
4. the cud sustained-release tablet according to claim 3 containing acetylamino evericin, it is characterised in that: the bonding
Agent is one of sodium carboxymethylcellulose, hydroxypropyl methyl cellulose and Arabic gum or a variety of.
5. the cud sustained-release tablet according to claim 4 containing acetylamino evericin, it is characterised in that: the lubrication
Agent is one or more of magnesium stearate, zinc stearate, aluminum stearate and talcum powder.
6. the cud sustained-release tablet according to claim 7 containing acetylamino evericin, it is characterised in that: the antioxygen
Agent be one of sodium hydrogensulfite, Sodium Metabisulfite, sodium thiosulfate, Butylated Hydroxytoluene and propylgallate or
Two kinds.
7. the cud sustained-release tablet according to claim 6 containing acetylamino evericin, it is characterised in that: the filling
Agent is one or both of starch, dextrin, microcrystalline cellulose, Icing Sugar and calcium sulfate.
8. a kind of preparation side of such as cud sustained-release tablet of any of claims 1-7 containing acetylamino evericin
Method, which comprises the steps of:
A, the acetylamino evericin of formula ratio, antioxidant and bulk erosion agent are added to stirring and dissolving in wetting agent,
It is spare；
B, specific gravity regulator, filler and the adhesive of formula ratio are put into mixing machine and are uniformly mixed, then by the step a
The solution of preparation is added in mixing machine, is stirred evenly, and softwood is made；
C, the softwood of the step b preparation is pelletized through granulator, is then transferred in dryer, is dried, whole grain after drying, whole grain
The mix lubricant that formula ratio is added afterwards is uniform, obtains particle；
D, particle obtained by the step c is subjected to tabletting through one-shot strength tablet press machine, obtains cud sustained-release tablet.
9. the preparation method of the cud sustained-release tablet according to claim 8 containing acetylamino evericin, feature exist
In: the wetting agent dosage is the 10-30% of the cud sustained-release tablet quality, and the wetting agent is one of water and ethyl alcohol
Or two kinds.
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Address after: 052165 68 Ganjiang Road, Shijiazhuang economic and Technological Development Zone, Hebei Applicant after: Hebei Weiyuan Pharmaceutical Co., Ltd Address before: 052165 68 Ganjiang Road, Shijiazhuang economic and Technological Development Zone, Hebei Applicant before: HEBEI VEYONG ANIMAL PHARMACEUTICAL Co.,Ltd. |
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Application publication date: 20190405 |