CN109528876A - A kind of Chinese materia medica preparation and preparation method thereof promoting Cesarean esction wound healing - Google Patents
A kind of Chinese materia medica preparation and preparation method thereof promoting Cesarean esction wound healing Download PDFInfo
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- CN109528876A CN109528876A CN201811594455.5A CN201811594455A CN109528876A CN 109528876 A CN109528876 A CN 109528876A CN 201811594455 A CN201811594455 A CN 201811594455A CN 109528876 A CN109528876 A CN 109528876A
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Abstract
The invention belongs to technical field of traditional Chinese medicine preparation to be made more particularly to a kind of Chinese materia medica preparation for promoting Cesarean esction wound healing of pachyrhizus, Cortex Eucommiae, five skin wind, common anotis herb, Moschus, the coptis, honeysuckle, rhizome of chuanxiong, Radix Glycyrrhizae, ginseng, radix ampelopsis and dandelion.Drug of the invention is safe and reliable, all medicine phases and have promoting blood circulation and stopping pain, detumescence and promoting granulation and antiphlogistic antibacterial etc. and other effects, for promote caesarean birth wound healing have the characteristics that curative for effect, quick, cure rate is high, without side-effects, the treatment that can be used in terms of wound.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, it particularly relates to a kind of Chinese medicine for promoting Cesarean esction wound healing
Preparation and preparation method thereof.
Background technique
Caesarean operation is the common operation of gynemetrics, is the main method for saving difficult labour mother and baby's life, it can be effective
Ground reduces the death rate of puerpera and baby.But caesarean birth is abdominal after all, and there is wound infection and healing problems.Less serious case
Subcutaneous fat liquefaction and the infection of wound shallow-layer are suppurated, and severe one abdominal wound all splits, and uterine cavity infection and uterine incision split and make
At big bleeding, peritonitis, septicemia etc., more serious person jeopardizes patient vitals, and it is long to cause patient's hospital stays, has aggravated warp
Ji burden, affects the quality of life of patient.Therefore prevent surgery cut infection in the operation of caesarean birth, reduce operation concurrently
It is very important for the generation of disease and sequelae.
The surface of a wound of operative incision be by notch locally stress inflammatory reaction, Collagen, capillary and at fiber finer
Born of the same parents' hyperplasia, granulation tissue growth, connective tissue reparation and re-epithelilization and reach healing.Bad wound healing is to cut open palace
Produce postoperative relatively common complication, the reason of generation may with following factor in relation to: (1) stomach fat of puerpera is often
Compare plump, notch exposure duration is longer in cesarean section, is influenced oxygenolysis may to occur by mechanism anti-
It answers, so that blood itself is transported poor plump Adipose tissue Blood supply further occurrence obstacle, the phenomenon that liquefaction of fat occur, influence
Wound healing；(2) immunity of puerpera decline, tissue edema and anaemia etc. affect the blood fortune of the tissue of fat, delay
The healing of notch；(3) part puerpera is associated with gestational diabetes, and hyperglycemia is not only conducive to bacterial growth, but also is easy to lure
Hair tissue edema is unfavorable for the healing of notch.The undesirable postpartum recovery occurred not only bad for puerpera of wound healing, and shield
Suffer from the major reason of dispute generation.Therefore, reinforce particularly significant to the processing of Cesarean esction puerpera's postpartum notch.
For cesarean postoperate because its patient has a delicate constitution, notch obstinate is common symptom, and medical field is mainly at present
It is primary treatments by bactericidal antiphlogistic, mostly uses antibiotic and sulfa drug, this treatment method is only suitable for controlling for a phase
It treats, it is poor to the second stage of incision in treatment effect and very serious to the damage of skin, be not suitable for using, there are also using outer now
The topical application of drug, such as adhesive plaster, but their often not no functions of anti-inflammatory, and it is poor with the antiphlogistic antibacterial adaptability of Western medicine,
It is easy to cause surface healing internal still the inflammation the phenomenon that, leads to the notch obstinate of patient, be good or bad.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of Chinese materia medica preparation for promoting Cesarean esction wound healing and its preparation sides
Method, to solve phenomena such as cesarean scar obstinate leads to inflammation and.
The present invention solves above-mentioned technical problem by the following technical programs:
A kind of Chinese materia medica preparation promoting Cesarean esction wound healing, in parts by weight, by 12 ~ 18 parts of pachyrhizus, 10 ~ 18 parts of Cortex Eucommiae, five
4 ~ 8 parts of skin wind, 8 ~ 16 parts of common anotis herb, 3 ~ 7 parts of Moschus, 15 ~ 20 parts of the coptis, 4 ~ 8 parts of honeysuckle, 18 ~ 26 parts of rhizome of chuanxiong, Radix Glycyrrhizae 3 ~ 6
Part, 10 ~ 20 parts of ginseng, 12 ~ 20 parts of radix ampelopsis and 2 ~ 5 parts of dandelion are made.
Preferably, by 13 ~ 17 parts of pachyrhizus, 12 ~ 16 parts of Cortex Eucommiae, 5 ~ 7 parts of five skin wind, 10 ~ 14 parts of common anotis herb, 4 ~ 6 parts of Moschus,
16 ~ 19 parts of the coptis, 5 ~ 7 parts of honeysuckle, 20 ~ 24 parts of rhizome of chuanxiong, 4 ~ 5 parts of Radix Glycyrrhizae, 12 ~ 18 parts of ginseng, 14 ~ 18 parts of radix ampelopsis and Pu are public
3 ~ 4 parts of English are made.
It is highly preferred that by 15 parts of pachyrhizus, 14 parts of Cortex Eucommiae, 6 parts of five skin wind, 12 parts of common anotis herb, 4.5 parts of Moschus, the coptis 17.5
Part, 6 parts of honeysuckle, 22 parts of rhizome of chuanxiong, 4.5 parts of Radix Glycyrrhizae, 15 parts of ginseng, 16 parts of radix ampelopsis and 3.5 parts of dandelion are made.
It is described promote Cesarean esction wound healing Chinese materia medica preparation preparation method the following steps are included:
(1) when pachyrhizus, Cortex Eucommiae, common anotis herb, Moschus, the coptis, rhizome of chuanxiong, Radix Glycyrrhizae, radix ampelopsis, dandelion first being used one section of distilled water immersion
Between after, heating boil extraction, extract in three times, it is spare to obtain filtrate for combined extract；
(2) ginseng, five skin wind, honeysuckle are respectively dried, then are ground into 100 ~ 200 targeted fine powders respectively, it is spare to obtain fine powder；
(3) by fine powder made from filtrate made from step (1) and step (2) be sufficiently mixed uniformly to get.
In the step (1), pachyrhizus, Cortex Eucommiae, common anotis herb, Moschus, the coptis, rhizome of chuanxiong, Radix Glycyrrhizae, radix ampelopsis, dandelion are first used
12 ~ 14 times of 2 ~ 3h of distilled water immersion, then 2.5 ~ 3.5h of extraction is boiled in heating, and filter residue is carried out second extraction, adds filter residue 6 by filtering
After 2 ~ 3h of extraction is boiled in ~ 9 times of water heating, filter residue is carried out third time extraction by filtering, and 5 ~ 8 times of water heating of filter residue is added to boil extraction
It is filtered after 1.5 ~ 2h, merges the extracting solution extracted three times, it is spare to obtain filtrate.
In the step (2), it is 4 ~ 7% that ginseng, five skin wind, honeysuckle, which are respectively dried to moisture content,.
The medicinal part of the pachyrhizus using pachyrhizus rattan.
The medicinal part of the five skins wind is the stem and leaf of five skin wind.
The dandelion medicinal part is the root of dandelion.
Application of the Chinese materia medica preparation in terms for the treatment of wound.
Ginseng has effects that reinforce vital energy, veins takes off admittedly, reinforce the spleen to benefit the lung, shengjin nourishing, tranquilize the mind and promote the intelligence.
Radix ampelopsis also known as mountainous region melon, wild sweet potato, V. amurensis seedling, Bai Gen, five pawl rattans, Tu core, are the dry of vitaceae radix ampelopsis
Dry root tuber, radix ampelopsis are distributed mainly on the ground such as North China, northeast, East China, Central-South and Shaanxi, Ningxia, Sichuan, spring, the excavation of two season of autumn, remove
Silt and radicula are removed, vertical valve or inclined tab is cut into, dries and Chinese medicine is made.Radix ampelopsis is used as medicine, and has clearing heat and detoxicating, carbuncle that disappears dissipating bind, myogenic
Sore.Main sore swollen toxin；Scrofula；Scald；Wet sore；A kind of malaria；Frightened epilepsy；Bloody flux；Intestines wind；Anal fistula；Leukorrhea；Traumatic injury；Wound goes out
Blood.
Dandelion also known as chrysanthemum seedling, dandelion, chrysanthemum youth, the wooden Chinese yam, slurry is very thin, mend patch, milk or bitter Mu etc..
Herbaceos perennial, leaf fall ovum shape lanceolar, fall lanceolar or long round shape lanceolar, scape 1 is isometric or slightly with leaf to several
It is long.Achene falls ovum shape lanceolar, crineous.The month at florescence 4-9, the fruiting period 5-10 month.It is distributed in extensively, North China, Central China, East China, east
Many places in the area Bei Deng, spring, summer, Qiu Sanji, field, roadside, hillside and Around the house have dandelion growth；Manually
Cultivate the unit or personal also increasing of dandelion.Dandelion have Detoxicating food-poisoning, dissipate stagnant gas, change heat toxin, disappear dislike swollen, tuberculosis,
The effect for the treatment of swollen, black beard and hair, strengthening the bone.White sauce: it applies and dislikes thorn, dermatitis contacta sore, that is, be cured." modern medicine also studied confirmation, Pu
Public English has very high medical value.A variety of Triterpenoidss contained by its root are taraxasterol, taraxerol, dandelion hardship
Element and caffeic acid, synanthrin, pectin；Herb contains inositol, asparagine, amaroid, saponin, resin, synanthrin, pectin, choline；Flower
Containing flavaxanthin, vitamin B 2 etc..Dandelion is double to staphylococcus aureus resistance bacterial strain, hemolytic streptococcus and pneumonia
Coccus, meningococcus, corynebacterium diphtheriae, pseudomonas aeruginosa, proteus, typhoid bacillus, shigella dysenteriae etc. have certain sterilization
Effect.
Rhizome of chuanxiong be Umbelliferae, Ligusticum perennial herb, it is 40-60 centimetres high.Rhizome is flourishing, forms irregular nodositas
Fist shape agglomerate, a kind of Chinese medicinal plant are usually used in rhizome hyoscine, and function promote breath and open depression dispels pathogenic wind and remove dampness, and promoting blood circulation and stopping pain controls headache
Revolve the diseases such as dizzy, costalgia abdomen pain, menostasis, difficult labour, ulcer sores.It is mainly cultivated in the ground such as Sichuan, Yunnan, Guizhou, Guangxi, Hubei.
Radix Glycyrrhizae also known as Glycyrrhiza Uralensis are a kind of help Chinese herbal medicines.Medicinal part is root and rhizome, and Medicinal Materials Characters root is in circle
Cylindricality, long 25~100cm, 0.6~3.5cm of diameter.Natural breeding, stem is tall and straight upright, and gas is micro- sweet and special.Major function is clear
Thermal detoxification, expelling phlegm and arresting coughing, stomach duct and abdomen etc..Radix Glycyrrhizae also has the function of coordinating the drug actions of a prescription.
Honeysuckle is just extensive and famous with its medical value since ancient times.Its effect is mainly clearing heat and detoxicating, cures mainly temperature
Sick fever, toxic-heat and blood stasis, ulcer serious case of furuncle etc..Modern study proves that honeysuckle contains the pharmacological activity such as chlorogenic acid, cyanidenon glycosides
Ingredient has the various pathogens such as hemolytic streptococcus, Staphylococcus aureus and infection of the upper respiratory tract Causative virus etc. stronger
Restraint, in addition can also strengthen immunity, Robust speaker feature, protect liver, antitumor, anti-inflammatory, antipyretic, hemostasis (blood coagulation), inhibition enteron aisle suction
Receive cholesterol etc..
The coptis, herbaceos perennial belong to Ranunculaceae Coptis in place of happiness cools, is wet.Rhizome yellow, normal branch are close
Raw majority fibrous root.Leaf whole base is raw；The long 5-12(-16 of petiole) cm；Blade heavily fortified point papery, ovate triangle, wide to reach 10cm, 3 totally cleave；
Central sliver has thin handle, and ovate diamond shape, long 3-8cm, wide 2-4cm, the anxious point in top, there are sharp sawtooth, the coptis in pinniform drastic crack, edge
It is a kind of conventional Chinese medicine.Antibacterial Function of Coptis: the double balls of staphylococcus aureus, hemolytic streptococcus, pneumococcus, meningitis
Bacterium, shigella dysenteriae, bacillus anthracis etc..Antivirus action: inhibit influenza virus, hepatitis B etc..Antiprotozoan effect: external to inhibit
Amoeba, Trichomonas vaginalis, trypanosome.
Pachyrhizus is also known as Fructus Fici tikouae, Entada phaseoloides, native melon etc., belongs to Moraceae, is stem, the leaf of moraceae plants pachyrhizus.Perennial fallen leaves
Liana, entirety tool lotion.Aerial root palpus shape, seeks connections in tree above or on stone.Stem is cylindrical or slightly flat, and sepia, branch is more, and memorandum is swollen
Greatly.Single leaf alternate；Petiole is 1~2 centimetre long；2, stipule, taper, apex point, full edge；Blade ovate, ovate oblong or length
Ellipse, is about 3~6 centimetres, 2~4 centimetres wide, apex blunt point, and edge has a wavy sawtooth, basal circular or heart-shaped, above
Green, have bristle, below thin, vein hairiness.Hypanthodium；Flower unisexuality, most, male and female flowering is born in cryptomere meat inflorescence
In support；Receptacle of inflorescence oblate spheroid, bronzing are born in and crawl on branch and there be not Yu Tuzhong partly.Follicarpium is small.4~May of florescence.It is born in low-relief terrain
Sparse woods, hillside or field side, roadside.It is distributed the ground such as Hunan, Hubei, Guizhou, Sichuan, Yunnan.Pachyrhizus can be used as medicine, and have heat-clearing,
The effect of dampness removing, promoting blood circulation, removing toxic substances.It can control cough due to wind-heat evil, dysentery, oedema, jaundice, rheumatalgia pain, hemorrhoid hemorrhage, menostasis, leukorrhagia,
Children's indigestion, nameless sores or boils.
Cortex Eucommiae also known as bakelite, the as dry bark of Eucommiaceae plant Cortex Eucommiae are the rare tonic herbs of China.Its is sweet in flavor,
It is warm-natured.Tonify the liver and kidney, strengthen muscles and bones, coordinating Chong and Conception Vessels, strengthen meridian and miscarriage prevention the effect of.Pain in waist and lower extremities caused by kidney-yang deficiency or acid can be treated
Soft inability, born of the same parents' tire caused by liver- qi invasion is not solid, the wet equal diseases of itching of scrotum.
Five skin wind Chinese names: snake contains potentilla chinensis, and alias: snake contains, cairo morningglory root or leaf, five skin wind, five leather and furs, a kind of grass of Potentilla
This plant.Five skin wind main roots are short, and lateral root is grown thickly such as palpus shape.Stem is most, elongated, slightly crawls, has the thin,tough silk shape hair of sparsely grow.Basal leaf tool
Long handle, stem leaf is smaller, and handle is short；Palmately compound leaf；Leaflet 3~5, oval or narrow obovate is 2~4 centimetres long, wide by 0.5~1.7
Centimetre, apex is perfectly round or blunt point, base portion wedge shape, and edge upper part has a rough sawn tooth, lower part full edge, be bordering on above it is hairless, below between arteries and veins
There is thin,tough silk shape hair；The wealthy lanceolar of stipule, base portion is in conjunction with petiole.Spend small, the coniform cyme of Cheng Dingsheng；Sepal 5, ovate is draped over one's shoulders
There is a little hair at aciculiform, calycule 5, near line shape, the back side.Function: heat-clearing arresting convulsion；Preventing malaria；It is relieving cough and reducing sputum；Removing toxic substances promoting blood circulation.The major functions: high
Hot infantile convulsion；Malaria；Cough with lung heat；Pertussis；Dysentery；Sore furuncle poison；Abscess of throat；Acute toothache；Shingles zoster；Hot eyes is swollen
Bitterly；Worm snake bite；Rheumatic numbness；Traumatic injury；Irregular menstruation；Traumatic hemorrhage.Usage and dosage: ecological environment: growth Yushan Hill
Slope or wetland.Resource distribution: national most area is distributed.
Common anotis herb is the herb of madder wort Patrinia scaniosaefolia Auricled Hedyotis Herb.It is distributed in the province such as Guangdong, Yunnan, Guizhou.It is dissipated with heat-clearing
The effect of stasis of blood, anti-inflammatory synthetism.It is usually used in hepatitis, treating rheumatic ostealgia, acute conjunctivitis is envious swollen.It is used for nameless sores or boils outside, fractures,
Traumatic hemorrhage.Upright draft is 60-80 centimetres high；The nearly Dan Sheng of stem, lower cylindrical shape, micro- top is in square column type, dredges villosity.
Leaf has short handle to life, and film quality, long round shape lanceolar is 4.5-7.5 centimetres long, 1-2 centimetres wide, and both ends are blunt or slightly short point, edge tool
Cristula, above hairless or scattered micro- pubescence, it is all hairless below in addition to vein has short bristle；6, the every side of lateral vein, it is extremely very thin,
It is obvious on blade two sides, with middle arteries upward stretching at an acute angle；Stipule is 3-4 millimeters long, and top splits into 2-4 bristle.Spend 4
Number, closely without stalk, several, intensively at small head, are then lined up the compound cyme of basidixed again, there is long total bennet；The long 1.5-3 of calyx
Millimeter, hairless, calyx pipe is spherical, and limb sliver is small, angular；Corolla white, infundibulate, by bristle, corolla lobe is blunt for throat；Stamen
It is outer with the prominent hat pipe of style.Capsule is oblate, and cracking is 2 carps when mature, and carp abdomen is directly split, and inside has seed number grain.Flower
Month phase 7-8.
Moschus also known as: when the door, navel are fragrant, musk deer navel is fragrant, four tastes are smelly, smelly son, cured son, fragrant navel.Moschus is the navel of male musk deer
The secretion of glandular sac between genitals is in granular form or blocky after dry, has special fragrance, there is bitter taste, can be made
Fragrance can also be used as medicine.It is central nervous excitation agent, external application can ease pain, reduce swelling.Moschus mainly contains moisture 22.56%, ash content
3.62% (wherein containing potassium, sodium, calcium, magnesium, iron, chlorine, sulfate radical, phosphate anion etc.), oxygenatedchemicals (wherein contains ammonium carbonate
1.15%, the ammonia 1.89% in ammonium salt, urea 0.40%, amino acid nitrogen 1.07%, nitrogen pool 9.15%), cholesterine 2.19%, crude fibre
0.59%, fatty acid 5.15%, muskone 1.2%.Moschus principle active component is muskone.It was once used in Niuhuang Pills, storax
In the products such as ball, Xihuang pills, Shexiang Baoxin Pills, Pien Tze Huang, Yunnan Baiyao, Liushen Pills.
In formula of the invention, ginseng have reinforce vital energy, veins takes off admittedly, reinforce the spleen to benefit the lung, shengjin nourishing, tranquilize the mind and promote the intelligence
Effect；Radix ampelopsis has effects that clearing heat and detoxicating, carbuncle that disappears dissipating bind, myogenic sore；Rhizome of chuanxiong has promote breath and open depression, dispels pathogenic wind and remove dampness, invigorates blood circulation
The effect of analgesic；Pachyrhizus has the effect of heat-clearing, dampness removing, promoting blood circulation, removing toxic substances, and ginseng, pachyrhizus, radix ampelopsis and 4 taste medicine of rhizome of chuanxiong are monarch
Medicine, the effect of playing inrigorating qi and promoting blood circulation, shengjin nourishing, expelling pus and promoting granulation jointly.
The most easy secondary infection of the trauma skin surface of a wound, control infection are the treatment most important tasks of skin trauma.Of the invention
In Chinese medicine preparation, dandelion has Detoxicating food-poisoning, dissipates stagnant gas, changes heat toxin, disappearing and dislike swollen, tuberculosis, treat swollen, black beard and hair, the function to strengthen the bone
Effect, in addition dandelion is to staphylococcus aureus resistance bacterial strain, hemolytic streptococcus and Diplococcus pneumopniae, meningococcus, white
Larynx bacillus, pseudomonas aeruginosa, proteus, typhoid bacillus, shigella dysenteriae etc. have certain bactericidal effect.Honeysuckle is to hemolytic
The various pathogens such as streptococcus, Staphylococcus aureus and infection of the upper respiratory tract Causative virus etc. have stronger restraint, in addition also
Can strengthen immunity, Robust speaker feature, protect liver, antitumor, anti-inflammatory, antipyretic, hemostasis (blood coagulation), inhibit intestinal absorption cholesterol etc..It is yellow
Connect antibacterial action: staphylococcus aureus, hemolytic streptococcus, pneumococcus, diplococcus meningitidis, shigella dysenteriae, anthrax bar
Antivirus action: bacterium etc. inhibits influenza virus, hepatitis B etc..Antiprotozoan effect: inhibit Amoeba, vagina drop in vitro
Worm, trypanosome.Dandelion, honeysuckle and coptis compatible use can play the function of collaboration enhancing bactericidal.Its is anti-infective
Effect is suitable with antibiotic, and dandelion, honeysuckle and coptis compatible use, anti-infection effect are single use one of which
Or 4 ~ 5 times of any two kinds of anti-infection effects.
Cortex Eucommiae, five skin wind, common anotis herb and Moschus compatible use, can not only promote the quick healing of wound, moreover it is possible to rise
To anti-inflammatory, detumescence, hemostasis, analgesic and other effects, preventing from scar after cicatrizing a wound.
Radix Glycyrrhizae primarily serves the effect of coordinating the drug actions of a prescription.
The beneficial effects of the present invention are: firstly, the present invention makes by using dandelion, honeysuckle and coptis compatibility
With, significantly enhance the synergistic effect of 3 taste medicines so that drug anti-infection effect obtained be single use it is one of or any
4 ~ 5 times of two kinds of anti-infection effects；Secondly, Cortex Eucommiae, five skin wind, common anotis herb and Moschus compatible use, can not only promote to hurt
The quick healing of mouth, moreover it is possible to play anti-inflammatory, detumescence, hemostasis, analgesic and other effects, preventing from scar after cicatrizing a wound；Again, this hair
It is bright use ginseng, pachyrhizus, radix ampelopsis and 4 taste medicine of rhizome of chuanxiong for monarch drug in a prescription, inrigorating qi and promoting blood circulation, shengjin nourishing, expelling pus and promoting granulation are played jointly
Effect significantly increases the therapeutic effect to notch；Finally, drug of the invention is safe and reliable, all medicine phases and there is promoting blood circulation to stop
Bitterly, detumescence and promoting granulation and antiphlogistic antibacterial etc. and other effects, for promoting caesarean birth wound healing that there is curative for effect, quick, healing
The features such as rate is high, without side-effects, the cure rate of 6d reaches as high as 100%, and is hardly visible scar.
Specific embodiment
In order to facilitate the understanding of those skilled in the art, below in conjunction with embodiment, the present invention will be further described.
Embodiment is only to the invention for example, not being limitation of the invention, the step of not illustrating in embodiment
It is prior art, is not described in detail herein.
Embodiment one
Raw material:
Pachyrhizus 12kg, Cortex Eucommiae 10kg, five skin wind 4kg, common anotis herb 8kg, Moschus 3kg, coptis 15kg, honeysuckle 4kg, rhizome of chuanxiong
18kg, Radix Glycyrrhizae 3kg, ginseng 10kg, radix ampelopsis 12kg and dandelion 2kg.
Preparation method:
(1) pachyrhizus, Cortex Eucommiae, common anotis herb, Moschus, the coptis, rhizome of chuanxiong, Radix Glycyrrhizae, radix ampelopsis, dandelion are first used into 12 times of distilled water immersions
2h, then heating, which is boiled, extracts 2.5h, and filter residue is carried out second extraction by filtering, after adding 6 times of water heating of filter residue to boil extraction 2h, mistake
Filter residue is carried out third time extraction by filter, is filtered after adding 5 times of water heating of filter residue to boil extraction 1.5h, is merged the extraction extracted three times
It is spare to obtain filtrate for liquid；
(2) ginseng, five skin wind, honeysuckle are respectively dried to moisture content is 4%, then is ground into 100 targeted fine powders respectively, is obtained
It is spare to obtain fine powder；
(3) by fine powder made from filtrate made from step (1) and step (2) be sufficiently mixed uniformly to get.
The medicinal part of the pachyrhizus using pachyrhizus rattan.
The medicinal part of the five skins wind is the stem and leaf of five skin wind.
The dandelion medicinal part is the root of dandelion.
Embodiment two
Raw material:
Pachyrhizus 18kg, Cortex Eucommiae 18kg, five skin wind 8kg, common anotis herb 16kg, Moschus 7kg, coptis 20kg, honeysuckle 8kg, rhizome of chuanxiong
26kg, Radix Glycyrrhizae 6kg, ginseng 20kg, radix ampelopsis 20kg and dandelion 5kg.
Preparation method:
Pachyrhizus, Cortex Eucommiae, common anotis herb, Moschus, the coptis, rhizome of chuanxiong, Radix Glycyrrhizae, radix ampelopsis, dandelion are first used into 14 times of distilled water immersion 3h, connect
Heating boil and extract 3.5h, filter residue is carried out second extraction by filtering, and after adding 9 times of water heating of filter residue to boil and extract 3h, filtering will
Filter residue carries out third time extraction, filters after adding 8 times of water heating of filter residue to boil extraction 2h, merges the extracting solution extracted three times, must filter
Liquid is spare；
It is 7% that ginseng, five skin wind, honeysuckle, which are respectively dried to moisture content, then is ground into 200 targeted fine powders respectively, is obtained thin
Powder is spare；
By fine powder made from filtrate made from step (1) and step (2) be sufficiently mixed uniformly to get.
The medicinal part of the pachyrhizus using pachyrhizus rattan.
The medicinal part of the five skins wind is the stem and leaf of five skin wind.
The dandelion medicinal part is the root of dandelion.
Embodiment three
Raw material:
Pachyrhizus 13kg, Cortex Eucommiae 12kg, five skin wind 5kg, common anotis herb 10kg, Moschus 4kg, coptis 16kg, honeysuckle 5kg, rhizome of chuanxiong
20kg, Radix Glycyrrhizae 4kg, ginseng 12kg, radix ampelopsis 14kg and dandelion 3kg.
Preparation method:
(1) pachyrhizus, Cortex Eucommiae, common anotis herb, Moschus, the coptis, rhizome of chuanxiong, Radix Glycyrrhizae, radix ampelopsis, dandelion are first used into 13 times of distilled water immersions
2.5h, then heating, which is boiled, extracts 3h, and filter residue is carried out second extraction by filtering, after adding 7 times of water heating of filter residue to boil extraction 2.5h,
Filter residue is carried out third time extraction by filtering, is filtered after adding 6 times of water heating of filter residue to boil extraction 1.8h, is merged the extraction extracted three times
It is spare to obtain filtrate for liquid；
(2) ginseng, five skin wind, honeysuckle are respectively dried to moisture content is 5%, then is ground into 180 targeted fine powders respectively, is obtained
It is spare to obtain fine powder；
(3) by fine powder made from filtrate made from step (1) and step (2) be sufficiently mixed uniformly to get.
The medicinal part of the pachyrhizus using pachyrhizus rattan.
The medicinal part of the five skins wind is the stem and leaf of five skin wind.
The dandelion medicinal part is the root of dandelion.
Example IV
Raw material:
Pachyrhizus 17kg, Cortex Eucommiae 16kg, five skin wind 7kg, common anotis herb 14kg, Moschus 6kg, coptis 19kg, honeysuckle 7kg, rhizome of chuanxiong
24kg, Radix Glycyrrhizae 5kg, ginseng 18kg, 14 ~ 18kg of radix ampelopsis and dandelion 4kg.
Preparation method:
(1) pachyrhizus, Cortex Eucommiae, common anotis herb, Moschus, the coptis, rhizome of chuanxiong, Radix Glycyrrhizae, radix ampelopsis, dandelion are first used into 13 times of distilled water immersions
2.5h, then heating, which is boiled, extracts 3h, and filter residue is carried out second extraction by filtering, after adding 8 times of water heating of filter residue to boil extraction 2.5h,
Filter residue is carried out third time extraction by filtering, is filtered after adding 6 times of water heating of filter residue to boil extraction 1.8h, is merged the extraction extracted three times
It is spare to obtain filtrate for liquid；
(2) ginseng, five skin wind, honeysuckle are respectively dried to moisture content is 6%, then is ground into 180 targeted fine powders respectively, is obtained
It is spare to obtain fine powder；
(3) by fine powder made from filtrate made from step (1) and step (2) be sufficiently mixed uniformly to get.
The medicinal part of the pachyrhizus using pachyrhizus rattan.
The medicinal part of the five skins wind is the stem and leaf of five skin wind.
The dandelion medicinal part is the root of dandelion.
Embodiment five
Raw material:
Pachyrhizus 15kg, Cortex Eucommiae 14kg, five skin wind 6kg, common anotis herb 12kg, Moschus 4.5kg, coptis 17.5kg, honeysuckle 6kg, river
Vault 22kg, Radix Glycyrrhizae 4.5kg, ginseng 15kg, radix ampelopsis 16kg and dandelion 3.5kg.
Preparation method:
(1) pachyrhizus, Cortex Eucommiae, common anotis herb, Moschus, the coptis, rhizome of chuanxiong, Radix Glycyrrhizae, radix ampelopsis, dandelion are first used into 13 times of distilled water immersions
2.5h, then heating, which is boiled, extracts 3h, and filter residue is carried out second extraction by filtering, after adding 7 times of water heating of filter residue to boil extraction 2.5h,
Filter residue is carried out third time extraction by filtering, is filtered after adding 6 times of water heating of filter residue to boil extraction 1.8h, is merged the extraction extracted three times
It is spare to obtain filtrate for liquid；
(2) ginseng, five skin wind, honeysuckle are respectively dried to moisture content is 5%, then is ground into 180 targeted fine powders respectively, is obtained
It is spare to obtain fine powder；
(3) by fine powder made from filtrate made from step (1) and step (2) be sufficiently mixed uniformly to get.
The medicinal part of the pachyrhizus using pachyrhizus rattan.
The medicinal part of the five skins wind is the stem and leaf of five skin wind.
The dandelion medicinal part is the root of dandelion.
The present invention is further illustrated below by way of test.These tests include that the safety of Chinese materia medica preparation of the present invention is commented
Estimate, clinical observation on the therapeutic effect test etc..
Test example one: skin allergy test
Selection cavy 45, half male and half female, 270 ± 15g of weight.Back two sides coat, area 3cm are removed with depilatory agent before experiment
It is not damaged that determination is observed after × 3cm, 20h.By treated, cavy is randomly divided into three groups, every group 15.First group to tested material
(Chinese materia medica preparation prepared by the present invention), second group of blank control (the not matrix of drug containing), third group positive controls (1%
2,4- dinitro-chloro-benzene solution), then respectively at 0h, for 24 hours, 48h, 72h observation evaluation skin allergy situation.
As the result is shown: tested group and each 15 guinea pig skins of blank control group do not occur erythema and oedema, positive controls
There is erythema after the tested area's self-excitation administration 1h of animal skin, 6h is most obvious, gradually subsides for 24 hours, and erythema still reluctantly may be used after 72h
See, sensitization rate is up to 100%.Do not occur erythema in 72h after the tested area's self-excitation administration of tested group of guinea pig skin and oedema is formed, with
Blank control group compares indifference, illustrates that Chinese materia medica preparation of the present invention not will lead to cutaneous anaphylaxis.
Test example two: skin sensibiligen test
Adult healthy white rabbit 9 are selected, before administration, removes animal backbone two sides coat, area about 140cm 2, 20h
As a child observation skin situations such as whether there is or not red and swollen, damages, there is similar situation and be not easy to continue to test.The production of damaged skin: really
After determining epilating area skin situation without exception, with warm water cleaning, iodophor disinfection draws " # " word with aseptic syringe needle and using oozing of blood as degree
Damaged skin.Intact skin and damaged skin white rabbit are handled respectively using Chinese materia medica preparation and bare substrate.It is removed afterwards with warm water for 24 hours
Tested material, observation, then smears identical tested material, continuous 7d.And after last coating 1h, for 24 hours, 48h, 72h, daily observation is simultaneously
Record the variation of the weight, skin, hair, eye and mucous membrane of animal, breathing, central nervous system, four limbs it is movable and other
Poisoning manifestations.
As the result is shown: in multiple dosing experiment, from 1h to the 7th day entry rabbit weight, skin, hair, eye and mucous membrane,
The movable variation of four limbs.As a result Chinese materia medica preparation experimental group and bare substrate control group and blank control group are said without significant difference
Bright Chinese materia medica preparation of the present invention is to the equal non-toxic reaction of complete and damaged skin.
Test example three: wound healing situation
1, data and method
The foundation of 1.1 scalpel backs scuffing mouse model: healthy mice 70 are taken, 18~22g of weight.All mouse anesthesias
Back part depilation 3cm × 2cm.Back of mice area 1cm × 1cm, depth 1cm are scratched using scalpel, sufficiently exposes the surface of a wound, selection
Back scratches mouse model 60, is randomly divided into 4 groups, every group 15.
1.2 grouping administrations and index determining: all groups are administered according to following dosage regimens: control group: applying give birth to outside
Manage salt water；1 group of test group: Chinese materia medica preparation prepared by external application embodiment 1；2 groups of test group: Chinese medicine system prepared by external application embodiment 2
Agent；3 groups of test group: Chinese materia medica preparation prepared by external application embodiment 5.According to 1g preparation/mouse dosage, phase is applied outside every 8h
The drug or preparation answered, template is affixed on surface of a wound description surface of a wound figure by daily 14:00 after scuffing, and paper is converted into wound again
Face area.And using the 1st day surface of a wound area as initial surface of a wound area,
1st day, 3 days, the healing areas of 6 days surface of a wound are compared with initial surface of a wound area, calculate the 3rd day, 6 days wound healings
Rate, healing rate=(initial surface of a wound area-do not heal surface of a wound area)/initial surface of a wound area × 100%.
2, experimental result
Influence of the Chinese materia medica preparation of the present invention of table 1 to wounds in mice healing state is scratched
| Group | 3d Wound healing rate (%) | 6d Wound healing rate (%) |
| Control group | 12.83 | 19.51 |
| Test group 1 | 80.39 | 92.67 |
| Test group 2 | 83.99 | 93.81 |
| Test group 3 | 89.15 | 98.79 |
Test result shows: compared with the control group, the healing rate of the Chinese materia medica preparation of preparation of the embodiment of the present invention is higher, this surface sheet
The drug that the Chinese materia medica preparation of invention preparation can be used as treatment skin trauma uses.The healing rate of Chinese materia medica preparation of the present invention mentions significantly
Height, healing time shorten.
Claims (10)
1. a kind of Chinese materia medica preparation for promoting Cesarean esction wound healing, it is characterised in that: in parts by weight, by 12 ~ 18 parts of pachyrhizus, Du
Secondary 10 ~ 18 parts, 4 ~ 8 parts of five skin wind, 8 ~ 16 parts of common anotis herb, 3 ~ 7 parts of Moschus, 15 ~ 20 parts of the coptis, 4 ~ 8 parts of honeysuckle, rhizome of chuanxiong 18 ~
26 parts, 3 ~ 6 parts of Radix Glycyrrhizae, 10 ~ 20 parts of ginseng, 12 ~ 20 parts of radix ampelopsis and 2 ~ 5 parts of dandelion are made.
2. as described in claim 1 promote Cesarean esction wound healing Chinese materia medica preparation, it is characterised in that: by 13 ~ 17 parts of pachyrhizus,
12 ~ 16 parts of Cortex Eucommiae, 5 ~ 7 parts of five skin wind, 10 ~ 14 parts of common anotis herb, 4 ~ 6 parts of Moschus, 16 ~ 19 parts of the coptis, 5 ~ 7 parts of honeysuckle, rhizome of chuanxiong
20 ~ 24 parts, 4 ~ 5 parts of Radix Glycyrrhizae, 12 ~ 18 parts of ginseng, 14 ~ 18 parts of radix ampelopsis and 3 ~ 4 parts of dandelion are made.
3. promoting the Chinese materia medica preparation of Cesarean esction wound healing as described in claim 1, it is characterised in that: by 15 parts of pachyrhizus, Du
Secondary 14 parts, 6 parts of five skin wind, 12 parts of common anotis herb, 4.5 parts of Moschus, 17.5 parts of the coptis, 6 parts of honeysuckle, 22 parts of rhizome of chuanxiong, Radix Glycyrrhizae 4.5
Part, 15 parts of ginseng, 16 parts of radix ampelopsis and 3.5 parts of dandelion are made.
4. the Chinese materia medica preparation of the promotion Cesarean esction wound healing as described in claim 1 ~ 3 any one, it is characterised in that: described
The medicinal part of pachyrhizus using pachyrhizus rattan.
5. the Chinese materia medica preparation of the promotion Cesarean esction wound healing as described in claim 1 ~ 3 any one, it is characterised in that: described
The medicinal part of five skin wind is the stem and leaf of five skin wind.
6. the Chinese materia medica preparation of the promotion Cesarean esction wound healing as described in claim 1 ~ 3 any one, it is characterised in that: described
Dandelion medicinal part is the root of dandelion.
7. the preparation method of the Chinese materia medica preparation of the promotion Cesarean esction wound healing as described in claim 1 ~ 3 any one, special
Sign is: the following steps are included:
(1) when pachyrhizus, Cortex Eucommiae, common anotis herb, Moschus, the coptis, rhizome of chuanxiong, Radix Glycyrrhizae, radix ampelopsis, dandelion first being used one section of distilled water immersion
Between after, heating boil extraction, extract in three times, it is spare to obtain filtrate for combined extract；
(2) ginseng, five skin wind, honeysuckle are respectively dried, then are ground into 100 ~ 200 targeted fine powders respectively, it is spare to obtain fine powder；
(3) by fine powder made from filtrate made from step (1) and step (2) be sufficiently mixed uniformly to get.
8. promoting the preparation method of the Chinese materia medica preparation of Cesarean esction wound healing as claimed in claim 7, it is characterised in that: described
In step (1), pachyrhizus, Cortex Eucommiae, common anotis herb, Moschus, the coptis, rhizome of chuanxiong, Radix Glycyrrhizae, radix ampelopsis, dandelion are first used into 12 ~ 14 times of distilled water
2 ~ 3h is impregnated, then 2.5 ~ 3.5h of extraction is boiled in heating, and filter residue is carried out second extraction by filtering, and 6 ~ 9 times of water heating of filter residue is added to boil
After 2 ~ 3h is extracted in boiling, filter residue is carried out third time extraction by filtering, is filtered after adding 5 ~ 8 times of water heating of filter residue to boil 1.5 ~ 2h of extraction,
Merge the extracting solution extracted three times, it is spare to obtain filtrate.
9. promoting the preparation method of the Chinese materia medica preparation of Cesarean esction wound healing as claimed in claim 7, it is characterised in that: described
In step (2), it is 4 ~ 7% that ginseng, five skin wind, honeysuckle, which are respectively dried to moisture content,.
10. the Chinese materia medica preparation of the promotion Cesarean esction wound healing as described in claim 1 ~ 9 any one, it is characterised in that: institute
State application of the Chinese materia medica preparation in terms for the treatment of wound.
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