CN109513117A - Easily easily from the Inner irradiation device taken out in vivo - Google Patents

Easily easily from the Inner irradiation device taken out in vivo Download PDF

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Publication number
CN109513117A
CN109513117A CN201811113381.9A CN201811113381A CN109513117A CN 109513117 A CN109513117 A CN 109513117A CN 201811113381 A CN201811113381 A CN 201811113381A CN 109513117 A CN109513117 A CN 109513117A
Authority
CN
China
Prior art keywords
radioactive source
connecting rod
medical
medical material
alloy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201811113381.9A
Other languages
Chinese (zh)
Inventor
阎尔坤
白红升
白鹏飞
李鹏飞
张海健
沈明哲
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TIANJIN SAIDE BIOLOGICAL PHARMACEUTICAL CO Ltd
Original Assignee
TIANJIN SAIDE BIOLOGICAL PHARMACEUTICAL CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TIANJIN SAIDE BIOLOGICAL PHARMACEUTICAL CO Ltd filed Critical TIANJIN SAIDE BIOLOGICAL PHARMACEUTICAL CO Ltd
Priority to CN201811113381.9A priority Critical patent/CN109513117A/en
Publication of CN109513117A publication Critical patent/CN109513117A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1014Intracavitary radiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1007Arrangements or means for the introduction of sources into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019Sources therefor
    • A61N2005/1022Generators, e.g. X-ray tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092Details
    • A61N2005/1098Enhancing the effect of the particle by an injected agent or implanted device

Abstract

The invention discloses easily easily from the Inner irradiation device taken out in vivo, including radioactive source, the radioactive source is that reeded cylinder is arranged in both ends of the surface, and an end or two ends for medical material connecting rod is fixedly connected with groove, and the quantity of connecting rod is 1 more than radioactive source.Operation of the present invention is easy, and operating time is short;It realizes accurate positioning of the radioactive source in tumour, avoids the variation for influencing source positions because of organ activity;Falling off or migrating for radioactive source is avoided, side effect, good effect are reduced;After treatment, taking-up radioactive source can be facilitated, noresidue reduces the unnecessary irradiation of normal tissue, reduces side reaction;It keeps organ complete and function perfects.

Description

Easily easily from the Inner irradiation device taken out in vivo
Technical field
The invention belongs to the field of medical instrument technology, are related to a kind of easy easily from the Inner irradiation device taken out in vivo.
Background technique
Malignant tumour, which has become, a kind of seriously threatens human health and common multiple disease.Currently, radiotherapy becomes One of the three big main means for treating tumour.When radiotherapy mainly penetrates tissue using ray, normal tissue and tumour Cell controls difference biological respinse mechanism caused by radioactive ray the growth and proliferation for the treatment of tumour cell.With operative treatment It is compared with chemotherapy, radiotherapy can retain the function of treated organ, and treatment side effect is small, can effectively ensure that patient is cured Life quality afterwards.
Radioactive prospecting instrument tumour is subjected to internal radiotherapy, also known as brachytherapy is percutaneous or art in lead to Implant needle or implanting device are crossed by a certain number of radioactive source implantation tumours position, the ray issued using radioactive source is for a long time to swollen The irradiation of oncocyte, killing or kill tumour cell, to achieve the purpose that treatment.The treatment technology is widely using various The implanted treatment of entity tumor, achieves good therapeutic effect.It is excellent that this method has that curative effect is high, easy to operate and wound is small etc. Point.But there is also some disadvantages for this method (radioactivity Implantation in Treating), as influenced after (1) implantation because of organ activity Source positions and arrangement cause dosage distribution to change, influence therapeutic effect;(2) falling off or migrate there are radioactive source;(3) Radioactive source stays in the body, and is not easy to take out from internal after treatment, to patient at heart or body brings certain burden;(4) clinical Operate relative complex, operating time is long.These disadvantages show in the treatment of head and neck neoplasm, superficial tumor and breast cancer etc. Become apparent from.
Summary of the invention
The purpose of the present invention is overcoming the prior art, one kind is provided and is mainly used for treating hand, foot, ear, tongue, nose The shallower tumour such as chamber, incidence, mammary gland, easy to operate, structure is simple, good effect, easily easily puts out of in vivo take out Treat device.
Technical solution of the present invention is summarized as follows:
Easily easily from the Inner irradiation device taken out in vivo, including radioactive source 2, radioactive source is that both ends of the surface setting is reeded Cylinder, an end or two ends for medical material connecting rod 1 are fixedly connected with groove, and the quantity of connecting rod 1 is than radioactive source 2 More 1.
The length of medical material connecting rod 1 is 5mm~500mm, and the medical material connecting rod (1) is solid hopkinson bar or hollow Bar, the diameter of solid hopkinson bar are 0.1mm~1.9mm, and the outer diameter of hollow stem is 0.1mm~1.9mm.
Radioactive source (2) length is 1mm~10mm, and diameter is 0.3mm~2mm.
Medical material is gold, silver, platinum, tantalum, niobium, zirconium, medical stainless steel, medical titanium, medical titanium alloy, Co-Cr-Mo conjunction Gold, gathers Co-Ni-Cr-Mo alloy, niti-shaped memorial alloy, polyether-polyurethane, polytetrafluoroethylene (PTFE), silicon rubber, polyester, nylon Methyl methacrylate, polyvinyl chloride, polyethylene, polypropylene, polystyrene, polyvinyl alcohol, poly(aryl ether ketone) or nonabsorable seam Zygonema.
The number of connecting rod (1) is 2-16.
It is fixedly connected as welding, is glued or rivets.
The end of connecting rod 1 and fixing clamp, snak link or button are flexibly connected.
The invention has the benefit that
(1) easy to operate, operating time is short;
(2) it realizes accurate positioning of the radioactive source in tumour, avoids the variation for influencing source positions because of organ activity;
(3) falling off or migrating for radioactive source is avoided, side effect, good effect are reduced;
(4) after treating, taking-up radioactive source can be facilitated, noresidue reduces the unnecessary irradiation of normal tissue, reduces pair Reaction;It keeps organ complete and function perfects.
Detailed description of the invention
Fig. 1 is easy easily from the Inner irradiation schematic device taken out in vivo.
Fig. 2 is 2 structural schematic diagram of radioactive source.
Fig. 3 is connecting rod and radioactive source connection schematic diagram.
Fig. 4 is the structural schematic diagram of snak link.
Fig. 5 is the structural schematic diagram of fixing clamp.
Fig. 6 is the implanting result schematic diagram for the internal radiotherapy device that the present invention easily can be taken off.
Specific embodiment
The present invention will be further described below with reference to the drawings.
Easily easily from the Inner irradiation device (see Fig. 1, Fig. 2 and Fig. 3) taken out in vivo, including radioactive source 2, radioactive source two End face is arranged reeded cylinder, and an end of medical material connecting rod 1 is fixedly connected or medical with the groove of radioactive source Two ends of material connecting rod 1 are fixedly connected with a respective groove for two radioactive sources respectively, are concatenated into medical material company Extension bar 1- radioactive source 2 is the structure of repetitive unit, and the quantity of connecting rod 1 is than radioactive source more than 21.
The preferred 15mm of the length of medical material connecting rod 1, can also select the arbitrary number in 5mm~500mm, such as 5mm, 10mm, 20mm, 30mm, 100mm, 150mm, 300mm, 500mm etc..
The medical material connecting rod (1) is solid hopkinson bar or hollow stem, and the preferred 0.6mm of the diameter of solid hopkinson bar can also be It is selected in 0.1mm~1.9mm, such as: 0.1mm, 0.3mm, 0.5mm, 1.2mm, 1.9mm etc..
The preferred 0.6mm of the outer diameter of hollow stem, can also select in 0.1mm~1.9mm, such as: 0.1mm, 0.3mm, 0.5mm, 1.2mm, 1.9mm etc..
Radioactive source (2) preferred 5.1mm of length, can also select the arbitrary number in 1mm~10mm, such as 1mm, 3mm, 6mm, 8mm, 10mm etc..Diameter is preferably 0.8mm, can also select the arbitrary number in 0.3mm~2mm, such as 0.3mm, 0.5mm, 0.6mm, 1.3mm, 1.5mm, 2mm etc..
Medical material is preferred: niti-shaped memorial alloy, can also select: gold, silver, platinum, tantalum, niobium, zirconium, 316L are medical stainless Steel, 304 medical stainless steels, commercial pure titanium, medical TC4 titanium alloy, Ti-15Mo titanium alloy, TNTZ alloy, Ti2448, Co-Cr- Mo alloy, Co-Ni-Cr-Mo alloy, food-grade polyether-polyurethane, food-grade polytetrafluoroethylene (PTFE), silicon rubber, polyester, nylon, food Grade polymethyl methacrylate, polyvinyl chloride, polyethylene, polypropylene, polystyrene, polyvinyl alcohol, poly(aryl ether ketone) or can not Absorbable suture line.
The number of connecting rod 1 is 2-16.
It is fixedly connected with preferred weld, it can also be using splicing or riveting.
Radioactive source 2 is iodine-125, palladium -103, Radium-224, cesium-131, Iridium-192 source, ytterbium -169, phosphorus -32 and Yttrium-90.It is preferred that For iodine-125, palladium -103, Radium-224, cesium-131.
1 middle part of connecting rod is circle perpendicular to the section configuration of long axis, oval, rectangle or other geometry polygons, but In view of the impression and applicability of patient, section of the present invention is preferably circular.
The end (one end not being connected with radioactive source) of connecting rod 1 and fixing clamp, snak link or button are flexibly connected.
The fixing clamp being flexibly connected with the end of connecting rod 1, snak link or button are commercially available.Including different geometries, In view of the applicability present invention uses snak link.
The operation that radioactive source is connect with medical material connecting rod is as follows:
The groove of the end of connecting rod and radioactive source is welded together by welding.
Easily easily from the use of the internal radiotherapy device (abbreviation radiotheraphy device) taken out in vivo (for treat hand, foot, The shallower tumour such as ear, tongue, nasal cavity, incidence, mammary gland):
Quantity and the position that radiotheraphy device is placed needed for determining according to patient tumors size, see Fig. 6, radiotheraphy device are placed in In implant needle or implanting device, after passing through tumour and skin with implant needle or implanting device, radiotheraphy device is released with push rod, passes through pulling The position of the connecting rod adjustment radioactive source of radiotheraphy device, extracts implant needle or implanting device out, with fixing clamp (can also with snak link or Button) the exposed both ends in extracutaneous connecting rod 1 are fixed, carry out radiotherapy.After treatment end, the fixing clamp of one end is removed (snak link or button), pulls out radiotheraphy device from the other end.
The above content is illustrate the specific embodiment party, and it cannot be said that of the invention to what the present invention was done in conjunction with the embodiments Formula is only limitted to these explanations.For general technical staff of the technical field of the invention, present inventive concept is not being departed from Under the premise of, several simple deductions and transformation can also be made, all shall be regarded as belonging to protection scope of the present invention.

Claims (7)

1. easily easily from the Inner irradiation device taken out in vivo, including radioactive source (2), it is characterized in that the radioactive source is both ends of the surface Reeded cylinder is set, and an end or two ends for medical material connecting rod (1) is fixedly connected with groove, connecting rod (1) quantity is than radioactive source (2) mostly 1.
2. the apparatus according to claim 1, it is characterized in that the length of the medical material connecting rod 1 is 5mm~500mm, The medical material connecting rod (1) is solid hopkinson bar or hollow stem, and the diameter of solid hopkinson bar is 0.1mm~1.9mm, the outer diameter of hollow stem For 0.1mm~1.9mm.
3. the apparatus according to claim 1, it is characterized in that the radioactive source (2) length is 1mm~10mm, diameter is 0.3mm~2mm.
4. the apparatus according to claim 1, it is characterized in that the medical material be gold, silver, platinum, tantalum, niobium, zirconium, it is medical not Become rusty steel, medical titanium, medical titanium alloy, Co-Cr-Mo alloy, Co-Ni-Cr-Mo alloy, niti-shaped memorial alloy, the poly- ammonia of polyethers Ester, polytetrafluoroethylene (PTFE), silicon rubber, polyester, nylon, polymethyl methacrylate, polyvinyl chloride, polyethylene, polypropylene, polyphenyl second Alkene, polyvinyl alcohol, poly(aryl ether ketone) or nonabsorable suture.
5. the apparatus according to claim 1, it is characterized in that the number of the connecting rod (1) is 2-16.
6. the apparatus according to claim 1, it is characterized in that described be fixedly connected as welding, be glued or rivet.
7. device described in one of -6 according to claim 1, it is characterized in that end and fixing clamp in the connecting rod (1), bullet Spring button or button are flexibly connected.
CN201811113381.9A 2018-09-25 2018-09-25 Easily easily from the Inner irradiation device taken out in vivo Pending CN109513117A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811113381.9A CN109513117A (en) 2018-09-25 2018-09-25 Easily easily from the Inner irradiation device taken out in vivo

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811113381.9A CN109513117A (en) 2018-09-25 2018-09-25 Easily easily from the Inner irradiation device taken out in vivo

Publications (1)

Publication Number Publication Date
CN109513117A true CN109513117A (en) 2019-03-26

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050113629A1 (en) * 2003-11-20 2005-05-26 Proxima Therapeutics Brachytherapy method and applicator for treatment of metastatic lesions in a load bearing region
CN1761500A (en) * 2003-03-17 2006-04-19 医疗物理有限公司 Products and methods for brachytherapy
CN101804238A (en) * 2009-02-17 2010-08-18 张福君 Radioactive particle chain connected by controllable and fast degradable magnesium and magnesium alloy
CN205729967U (en) * 2016-04-11 2016-11-30 王娟 A kind of radioactive particle chain

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1761500A (en) * 2003-03-17 2006-04-19 医疗物理有限公司 Products and methods for brachytherapy
US20050113629A1 (en) * 2003-11-20 2005-05-26 Proxima Therapeutics Brachytherapy method and applicator for treatment of metastatic lesions in a load bearing region
CN101804238A (en) * 2009-02-17 2010-08-18 张福君 Radioactive particle chain connected by controllable and fast degradable magnesium and magnesium alloy
CN205729967U (en) * 2016-04-11 2016-11-30 王娟 A kind of radioactive particle chain

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Application publication date: 20190326