CN109511736A - A kind of probiotic beverage and preparation method thereof with protection liver function - Google Patents
A kind of probiotic beverage and preparation method thereof with protection liver function Download PDFInfo
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- 239000006041 probiotic Substances 0.000 title claims abstract description 23
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 23
- 235000013361 beverage Nutrition 0.000 title claims abstract description 18
- 230000000529 probiotic effect Effects 0.000 title claims abstract description 18
- 230000003908 liver function Effects 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000000843 powder Substances 0.000 claims abstract description 98
- 241000894006 Bacteria Species 0.000 claims abstract description 45
- 241000901050 Bifidobacterium animalis subsp. lactis Species 0.000 claims abstract description 30
- 240000001046 Lactobacillus acidophilus Species 0.000 claims abstract description 27
- 244000199866 Lactobacillus casei Species 0.000 claims abstract description 27
- 241000193171 Clostridium butyricum Species 0.000 claims abstract description 17
- 235000013312 flour Nutrition 0.000 claims abstract description 16
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 14
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims abstract description 13
- 229920001202 Inulin Polymers 0.000 claims abstract description 13
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 13
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 13
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 13
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims abstract description 13
- 229940029339 inulin Drugs 0.000 claims abstract description 13
- 229960001375 lactose Drugs 0.000 claims abstract description 13
- 239000008101 lactose Substances 0.000 claims abstract description 13
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 13
- 235000020185 raw untreated milk Nutrition 0.000 claims abstract description 10
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 7
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 7
- 239000011718 vitamin C Substances 0.000 claims abstract description 7
- 239000004615 ingredient Substances 0.000 claims abstract description 6
- 235000013336 milk Nutrition 0.000 claims abstract description 5
- 239000008267 milk Substances 0.000 claims abstract description 5
- 210000004080 milk Anatomy 0.000 claims abstract description 5
- 238000011081 inoculation Methods 0.000 claims description 25
- 235000004879 dioscorea Nutrition 0.000 claims description 15
- 239000001963 growth medium Substances 0.000 claims description 15
- 230000001954 sterilising effect Effects 0.000 claims description 15
- 239000003814 drug Substances 0.000 claims description 13
- 239000000463 material Substances 0.000 claims description 11
- 239000000047 product Substances 0.000 claims description 11
- 238000000855 fermentation Methods 0.000 claims description 10
- 239000012467 final product Substances 0.000 claims description 10
- 229940009289 bifidobacterium lactis Drugs 0.000 claims description 9
- 229940079593 drug Drugs 0.000 claims description 7
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims description 6
- 235000013958 Lactobacillus casei Nutrition 0.000 claims description 6
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims description 6
- 229940017800 lactobacillus casei Drugs 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 235000002722 Dioscorea batatas Nutrition 0.000 claims description 5
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims description 5
- 240000001811 Dioscorea oppositifolia Species 0.000 claims description 5
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims description 5
- YTAHJIFKAKIKAV-XNMGPUDCSA-N [(1R)-3-morpholin-4-yl-1-phenylpropyl] N-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]carbamate Chemical compound O=C1[C@H](N=C(C2=C(N1)C=CC=C2)C1=CC=CC=C1)NC(O[C@H](CCN1CCOCC1)C1=CC=CC=C1)=O YTAHJIFKAKIKAV-XNMGPUDCSA-N 0.000 claims description 5
- 239000000498 cooling water Substances 0.000 claims description 5
- 230000008030 elimination Effects 0.000 claims description 5
- 238000003379 elimination reaction Methods 0.000 claims description 5
- 230000004151 fermentation Effects 0.000 claims description 5
- 238000004108 freeze drying Methods 0.000 claims description 5
- 238000000265 homogenisation Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 238000000386 microscopy Methods 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- 230000003068 static effect Effects 0.000 claims description 5
- 235000015099 wheat brans Nutrition 0.000 claims description 5
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 241000193403 Clostridium Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
- 230000001580 bacterial effect Effects 0.000 abstract description 2
- 238000001816 cooling Methods 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract 1
- 208000010706 fatty liver disease Diseases 0.000 description 9
- 208000004930 Fatty Liver Diseases 0.000 description 7
- 206010019708 Hepatic steatosis Diseases 0.000 description 7
- 231100000240 steatosis hepatitis Toxicity 0.000 description 7
- 230000000968 intestinal effect Effects 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 201000010099 disease Diseases 0.000 description 3
- 230000000711 cancerogenic effect Effects 0.000 description 2
- 231100000315 carcinogenic Toxicity 0.000 description 2
- 231100000284 endotoxic Toxicity 0.000 description 2
- 230000002346 endotoxic effect Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 210000004347 intestinal mucosa Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 208000007082 Alcoholic Fatty Liver Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010006956 Calcium deficiency Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010016262 Fatty liver alcoholic Diseases 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 208000026594 alcoholic fatty liver disease Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- -1 butyric acid Chemical class 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 230000008944 intestinal immunity Effects 0.000 description 1
- 244000000074 intestinal pathogen Species 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 235000021391 short chain fatty acids Nutrition 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
- A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/1307—Milk products or derivatives; Fruit or vegetable juices; Sugars, sugar alcohols, sweeteners; Oligosaccharides; Organic acids or salts thereof or acidifying agents; Flavours, dyes or pigments; Inert or aerosol gases; Carbonation methods
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/1315—Non-milk proteins or fats; Seeds, pulses, cereals or soja; Fatty acids, phospholipids, mono- or diglycerides or derivatives therefrom; Egg products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/1322—Inorganic compounds; Minerals, including organic salts thereof, oligo-elements; Amino-acids, peptides, protein-hydrolysates or derivatives; Nucleic acids or derivatives; Yeast extract or autolysate; Vitamins; Antibiotics; Bacteriocins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/113—Acidophilus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/125—Casei
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/531—Lactis
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The invention belongs to probiotic beverage fields, more particularly to a kind of probiotic beverage and preparation method thereof with protection liver function, ingredient including following weight proportion: 10-40 parts of clostridium butyricum bacterium powder, 10-40 parts of lactobacillus acidophilus bacterium powder, 10-40 parts of Lactobacillus casei bacterium powder, 10-40 parts of bifidobacterium lactis bacterium powder, 1-11 parts of vitamin C, 24-34 parts of oligofructose, 2-12 parts of maltodextrin, 2-12 parts of lactose, 5-15 parts of inulin, 100-120 parts of raw milk, 2-5 parts of wheatfeed, 2-5 parts of yam flour, the present invention will be by probiotics bacterial powder and vitamin C, oligofructose and maltodextrin, lactose and inulin are added in mixed milk liquor, fermented cooling finished product, bacterium powder prescription is rigorous, compatibility science, it is significant in efficacy, it can both symptoms and root causes , liver-protective effect is played rapidly and fundamentally.
Description
Technical field
The invention belongs to probiotic beverage fields, and in particular to it is a kind of with protection liver function probiotic beverage and its
Preparation method.
Background technique
Probiotic beverage currently on the market is varied, and emphasis is also different, such as the height of calcium deficiency crowd
Calcium milk and beneficial bacterium milk etc. for constipation crowd.With the raising and the accelerating rhythm of life of people's quality of life, mistake
The living habits such as amount drinks, stays up late, diet is irregular can all damage liver, and fatty liver disease is viral as being only second to
The second largest hepatopathy of hepatitis, is just seriously threatening the health of compatriots.Fatty liver is a kind of common clinical picture, rather than a kind of independence
Disease.The common cause of disease has: obesity fatty liver, alcoholic fatty liver, dystrophic fatty liver, diabetic fatty liver,
Drug fatty liver, quick weight-lossing fatty liver, Chinese medicine and Western medicine can not all meet this requirement simultaneously at present, and doctor trained in Western medicine cannot be marked
Originally simultaneous to control, side effect is obvious, and the Chinese medicine course for the treatment of is longer, is extremely difficult to good result in a short time.The prior art also occurs some auxiliary
The dietotherapy mode of drug therapy is helped, but exists mostly ineffective and single cannot lean on dietotherapy.In view of the secondary work of poison of drug
With the prior art urgently needs to study can liver-protective probiotic beverage using dietotherapy.
Summary of the invention
In order to solve shortcomings and deficiencies of the prior art, the present invention provides a kind of probiotics drink with protection liver function
Material and preparation method thereof, the present invention will add probiotics bacterial powder and vitamin C, oligofructose and maltodextrin, lactose and inulin
Enter into mixed milk liquor, fermented cooling finished product, bacterium powder prescription is rigorous, and compatibility science, significant in efficacy, energy table sheet is simultaneous
It controls, plays liver-protective effect rapidly and fundamentally.
It is to solve technical solution used by its technical problem:
A kind of probiotic beverage with protection liver function, the ingredient including following weight proportion: clostridium butyricum bacterium powder 10-40
Part, 10-40 parts of lactobacillus acidophilus bacterium powder, 10-40 parts of Lactobacillus casei bacterium powder, 10-40 parts of bifidobacterium lactis bacterium powder, vitamin
C1-11 parts, 24-34 parts of oligofructose, 2-12 parts of maltodextrin, 2-12 parts of lactose, 5-15 parts of inulin, raw milk 100-120
Part, 2-5 parts of wheatfeed, 2-5 parts of yam flour.
The preparation method of the above-mentioned probiotic beverage with protection liver function, comprising the following steps:
A, strain is selected: selection clostridium butyricum strain；
B, the production of hybrid seeds: selecting sterile environment, and strain transfer needle is taken out and is put into 500 milliliters of triangular flasks equipped with culture medium,
Then it seals bottleneck to be put into incubator, 37 DEG C of the temperature of incubator, static gas wave refrigerator 12 hours；
C, it sterilizes: 100 liters of fermentors being subjected to empty elimination bacterium, culture medium is then placed in and sterilizes, 121 degrees Celsius of sterilising temp
More than, pressure inside the tank 0.12MPa, continuing 20min sterilizing terminates, and temperature in tank is then down to 37 DEG C with cooling water, tank internal pressure
Power is down to 0.01MPa；
D, it is inoculated with: the seed in incubator being put into desinfection chamber first and is sampled microscopy, is inoculated with, unscrew inoculation mouth sealing
Lid leads to filtrated air in 100 liters of tanks, guarantees that pressure inside the tank will not be zero, is placed on inoculation mouth with inoculation flame ring, lights fire
After flame circle, inoculation lid is fully opened, then triangular flask is placed on above flame ring, triangular flask is opened, seed is poured into tank,
After will inoculation lid tighten, into tank lead to filtrated air, pressure inside the tank to 0.06MPa stop, progress pressure maintaining, temperature holding 37
DEG C, 0.06 MPa of pressure, speed of agitator is adjusted to 60r/min, cultivates 12 hours；
E, culture transferring: step b is carried out to 1000 liters of fermentors, the strain in 100 liters of fermentor is then passed through into the pipeline of sterilizing
It moving in the fermentor that 1000 liters prepare culture medium, temperature is kept for 37 DEG C, and 0.06 MPa of pressure, speed of agitator is adjusted to 60r/min,
It cultivates 12 hours, side viable count is sampled after growth is good in 1000 liters of fermentors；
F, be centrifuged: bacterium solution is rotated clockwise by centrifuge, centrifuge speed for 16000r/min, carries out bacterium solution separation, is completed
After take out bacterium mud；
G, it is lyophilized: bacterium mud being placed in the plate layer of freeze dryer, freeze-drying operation is carried out, -45 DEG C of temperature of freeze dryer rear lane is taken out
Vacuum；
H, bacterium powder bacterium powder: is obtained after crushing；
I, lactobacillus acidophilus bacterium powder processed, Lactobacillus casei bacterium powder and bifidobacterium lactis bacterium powder: by lactobacillus acidophilus, Lactobacillus casei
Step b to step h is repeated with bifidobacterium lactis, obtains lactobacillus acidophilus bacterium powder, Lactobacillus casei bacterium powder and bifidobacterium lactis bacterium
Powder；
J, wheatfeed processed: wheat bran is ground into powder, and crosses 200 meshes to obtain the final product；
K, yam flour processed: Chinese yam being shredded, is ground into powder, and crosses 200 meshes to obtain the final product；
L, wheatfeed is made in step j and step k and yam flour is added in raw milk, be uniformly mixed, be then preheating to 50 DEG C,
It carries out homogeneous and obtains mixed material, homogenization pressure is 18 Mpa -20Mpa；Then by the mixed material after homogeneous be placed in 90 DEG C-
It carries out disinfection 120 seconds, is cooled to obtained mixed liquor after 33 DEG C at 95 DEG C；
M, finished product: by clostridium butyricum bacterium powder, lactobacillus acidophilus bacterium powder, Lactobacillus casei bacterium powder, bifidobacterium lactis bacterium powder and Wei Sheng
Plain C, oligofructose, maltodextrin, lactose and inulin are matched according to the drug weight and are configured, and are added to made from step l and are mixed
It closes in liquid, is uniformly mixed post-fermentation 12 hours, terminate fermentation, cool to 10 DEG C, finished product.
The effect of various probiotics of the invention is as follows:
Clostridium butyricum: also known as Miyarisan, clostridium butyricum, it can produce the short chain fatty acids such as butyric acid, be gut epithelium
The Major Nutrient substance of histiocytic regeneration and reparation, repairs impaired intestinal mucosa, and promote the production of beneficial bacterium in enteron aisle,
Inhibit beneficial bacterium breeding；
Lactobacillus acidophilus: one of people and animal intestinal tract normal flora inhibit harmful bacteria growth, promote intestinal beneficial bacterium growth, adjust
The intestinal microecology system of whole disorder；
Lactobacillus casei: enhancing host accelerates to remove intestinal pathogens, control to the nonspecific resistance of microbial pathogens
Enteric flora disturbance and enhancing enteron aisle permeability are treated, is played and is adjusted intestinal flora balance, human consumption is promoted to absorb；
Bifidobacterium lactis: bifidobacterium lactis cell can adsorb the carcinogenic and mutagenic matter in food, to protect body thin
Damage of the born of the same parents from these carcinogens.Bifidobacterium lactis can inhibit many spoilage organisms of enteron aisle by adjusting normal intestinal flora
Growth, to reduce the carcinogenic generation of some intestines source property.The harmful bacteria of human body intestinal canal, which generates and discharges endotoxin, enters blood
In, damage will cause to liver.Bifidobacterium lactis preparation can inhibit to generate endotoxic harmful bacteria quantity, thus to liver
Patient plays good therapeutic effect.
The beneficial effects of the present invention are: the present invention is compared with existing simple Chinese medicine, Western medicine and probiotics in the market,
Not only enteron aisle, which can have been improved, inherently improves human body constitution, but also can adjust the intestinal microecology system of disorder rapidly, directly repairs
Impaired intestinal mucosa again improves intestinal immunity, inhibits to generate endotoxic harmful bacteria quantity, treating both manifestation and root cause of disease.Fundamentally
Alleviation fatty liver is played, and has liver-protective curative effect.
Specific embodiment
Embodiment 1:
A kind of probiotic beverage with protection liver function, the ingredient including following weight proportion: 10 parts of clostridium butyricum bacterium powder,
10 parts of lactobacillus acidophilus bacterium powder, 10 parts of Lactobacillus casei bacterium powder, 10 parts of bifidobacterium lactis bacterium powder, 1 part of vitamin C, oligofructose
24 parts, 2 parts of maltodextrin, 2 parts of lactose, 5 parts of inulin, 100 parts of raw milk, 2 parts of wheatfeed, 2 parts of yam flour.
The preparation method of the above-mentioned probiotic beverage with protection liver function, comprising the following steps:
A, strain is selected: selection clostridium butyricum strain；
B, the production of hybrid seeds: selecting sterile environment, and strain transfer needle is taken out and is put into 500 milliliters of triangular flasks equipped with culture medium,
Then it seals bottleneck to be put into incubator, 37 DEG C of the temperature of incubator, static gas wave refrigerator 12 hours；
C, it sterilizes: 100 liters of fermentors being subjected to empty elimination bacterium, culture medium is then placed in and sterilizes, 121 degrees Celsius of sterilising temp
More than, pressure inside the tank 0.12MPa, continuing 20min sterilizing terminates, and temperature in tank is then down to 37 DEG C with cooling water, tank internal pressure
Power is down to 0.01MPa；
D, it is inoculated with: the seed in incubator being put into desinfection chamber first and is sampled microscopy, is inoculated with, unscrew inoculation mouth sealing
Lid leads to filtrated air in 100 liters of tanks, guarantees that pressure inside the tank will not be zero, is placed on inoculation mouth with inoculation flame ring, lights fire
After flame circle, inoculation lid is fully opened, then triangular flask is placed on above flame ring, triangular flask is opened, seed is poured into tank,
After will inoculation lid tighten, into tank lead to filtrated air, pressure inside the tank to 0.06MPa stop, progress pressure maintaining, temperature holding 37
DEG C, 0.06 MPa of pressure, speed of agitator is adjusted to 60r/min, cultivates 12 hours；
E, culture transferring: step b is carried out to 1000 liters of fermentors, the strain in 100 liters of fermentor is then passed through into the pipeline of sterilizing
It moving in the fermentor that 1000 liters prepare culture medium, temperature is kept for 37 DEG C, and 0.06 MPa of pressure, speed of agitator is adjusted to 60r/min,
It cultivates 12 hours, side viable count is sampled after growth is good in 1000 liters of fermentors；
F, be centrifuged: bacterium solution is rotated clockwise by centrifuge, centrifuge speed for 16000r/min, carries out bacterium solution separation, is completed
After take out bacterium mud；
G, it is lyophilized: bacterium mud being placed in the plate layer of freeze dryer, freeze-drying operation is carried out, -45 DEG C of temperature of freeze dryer rear lane is taken out
Vacuum；
H, bacterium powder bacterium powder: is obtained after crushing；
I, lactobacillus acidophilus bacterium powder processed, Lactobacillus casei bacterium powder and bifidobacterium lactis bacterium powder: by lactobacillus acidophilus, Lactobacillus casei
Step b to step h is repeated with bifidobacterium lactis, obtains lactobacillus acidophilus bacterium powder, Lactobacillus casei bacterium powder and bifidobacterium lactis bacterium
Powder；
J, wheatfeed processed: wheat bran is ground into powder, and crosses 200 meshes to obtain the final product；
K, yam flour processed: Chinese yam being shredded, is ground into powder, and crosses 200 meshes to obtain the final product；
L, wheatfeed is made in step j and step k and yam flour is added in raw milk, be uniformly mixed, be then preheating to 50 DEG C,
It carries out homogeneous and obtains mixed material, homogenization pressure is 18 Mpa；Then the mixed material after homogeneous is placed at 90 DEG C and is disappeared
Poison 120 seconds cools to obtained mixed liquor after 33 DEG C；
M, finished product: by clostridium butyricum bacterium powder, lactobacillus acidophilus bacterium powder, Lactobacillus casei bacterium powder, bifidobacterium lactis bacterium powder and Wei Sheng
Plain C, oligofructose, maltodextrin, lactose and inulin are matched according to the drug weight and are configured, and are added to made from step l and are mixed
It closes in liquid, is uniformly mixed post-fermentation 12 hours, terminate fermentation, cool to 10 DEG C, finished product.
Embodiment 2:
A kind of probiotic beverage with protection liver function, the ingredient including following weight proportion: 40 parts of clostridium butyricum bacterium powder,
40 parts of lactobacillus acidophilus bacterium powder, 40 parts of Lactobacillus casei bacterium powder, 40 parts of bifidobacterium lactis bacterium powder, 11 parts of vitamin C, oligofructose
34 parts, 12 parts of maltodextrin, 12 parts of lactose, 15 parts of inulin, 120 parts of raw milk, 5 parts of wheatfeed, 5 parts of yam flour.
The preparation method of the above-mentioned probiotic beverage with protection liver function, comprising the following steps:
A, strain is selected: selection clostridium butyricum strain；
B, the production of hybrid seeds: selecting sterile environment, and strain transfer needle is taken out and is put into 500 milliliters of triangular flasks equipped with culture medium,
Then it seals bottleneck to be put into incubator, 37 DEG C of the temperature of incubator, static gas wave refrigerator 12 hours；
C, it sterilizes: 100 liters of fermentors being subjected to empty elimination bacterium, culture medium is then placed in and sterilizes, 121 degrees Celsius of sterilising temp
More than, pressure inside the tank 0.12MPa, continuing 20min sterilizing terminates, and temperature in tank is then down to 37 DEG C with cooling water, tank internal pressure
Power is down to 0.01MPa；
D, it is inoculated with: the seed in incubator being put into desinfection chamber first and is sampled microscopy, is inoculated with, unscrew inoculation mouth sealing
Lid leads to filtrated air in 100 liters of tanks, guarantees that pressure inside the tank will not be zero, is placed on inoculation mouth with inoculation flame ring, lights fire
After flame circle, inoculation lid is fully opened, then triangular flask is placed on above flame ring, triangular flask is opened, seed is poured into tank,
After will inoculation lid tighten, into tank lead to filtrated air, pressure inside the tank to 0.06MPa stop, progress pressure maintaining, temperature holding 37
DEG C, 0.06 MPa of pressure, speed of agitator is adjusted to 60r/min, cultivates 12 hours；
E, culture transferring: step b is carried out to 1000 liters of fermentors, the strain in 100 liters of fermentor is then passed through into the pipeline of sterilizing
It moving in the fermentor that 1000 liters prepare culture medium, temperature is kept for 37 DEG C, and 0.06 MPa of pressure, speed of agitator is adjusted to 60r/min,
It cultivates 12 hours, side viable count is sampled after growth is good in 1000 liters of fermentors；
F, be centrifuged: bacterium solution is rotated clockwise by centrifuge, centrifuge speed for 16000r/min, carries out bacterium solution separation, is completed
After take out bacterium mud；
G, it is lyophilized: bacterium mud being placed in the plate layer of freeze dryer, freeze-drying operation is carried out, -45 DEG C of temperature of freeze dryer rear lane is taken out
Vacuum；
H, bacterium powder bacterium powder: is obtained after crushing；
I, lactobacillus acidophilus bacterium powder processed, Lactobacillus casei bacterium powder and bifidobacterium lactis bacterium powder: by lactobacillus acidophilus, Lactobacillus casei
Step b to step h is repeated with bifidobacterium lactis, obtains lactobacillus acidophilus bacterium powder, Lactobacillus casei bacterium powder and bifidobacterium lactis bacterium
Powder；
J, wheatfeed processed: wheat bran is ground into powder, and crosses 200 meshes to obtain the final product；
K, yam flour processed: Chinese yam being shredded, is ground into powder, and crosses 200 meshes to obtain the final product；
L, wheatfeed is made in step j and step k and yam flour is added in raw milk, be uniformly mixed, be then preheating to 50 DEG C,
It carries out homogeneous and obtains mixed material, homogenization pressure 20Mpa；Then by the mixed material after homogeneous be placed at 90 DEG C -95 DEG C into
Row disinfection 120 seconds cools to obtained mixed liquor after 33 DEG C；
M, finished product: by clostridium butyricum bacterium powder, lactobacillus acidophilus bacterium powder, Lactobacillus casei bacterium powder, bifidobacterium lactis bacterium powder and Wei Sheng
Plain C, oligofructose, maltodextrin, lactose and inulin are matched according to the drug weight and are configured, and are added to made from step l and are mixed
It closes in liquid, is uniformly mixed post-fermentation 12 hours, terminate fermentation, cool to 10 DEG C, finished product.
Embodiment 3:
A kind of probiotic beverage with protection liver function, the ingredient including following weight proportion: 25 parts of clostridium butyricum bacterium powder,
25 parts of lactobacillus acidophilus bacterium powder, 25 parts of Lactobacillus casei bacterium powder, 25 parts of bifidobacterium lactis bacterium powder, 6 parts of vitamin C, oligofructose
29 parts, 7 parts of maltodextrin, 7 parts of lactose, 10 parts of inulin, 110 parts of raw milk, 3.5 parts of wheatfeed, 3.5 parts of yam flour.
The preparation method of the above-mentioned probiotic beverage with protection liver function, comprising the following steps:
A, strain is selected: selection clostridium butyricum strain；
B, the production of hybrid seeds: selecting sterile environment, and strain transfer needle is taken out and is put into 500 milliliters of triangular flasks equipped with culture medium,
Then it seals bottleneck to be put into incubator, 37 DEG C of the temperature of incubator, static gas wave refrigerator 12 hours；
C, it sterilizes: 100 liters of fermentors being subjected to empty elimination bacterium, culture medium is then placed in and sterilizes, 121 degrees Celsius of sterilising temp
More than, pressure inside the tank 0.12MPa, continuing 20min sterilizing terminates, and temperature in tank is then down to 37 DEG C with cooling water, tank internal pressure
Power is down to 0.01MPa；
D, it is inoculated with: the seed in incubator being put into desinfection chamber first and is sampled microscopy, is inoculated with, unscrew inoculation mouth sealing
Lid leads to filtrated air in 100 liters of tanks, guarantees that pressure inside the tank will not be zero, is placed on inoculation mouth with inoculation flame ring, lights fire
After flame circle, inoculation lid is fully opened, then triangular flask is placed on above flame ring, triangular flask is opened, seed is poured into tank,
After will inoculation lid tighten, into tank lead to filtrated air, pressure inside the tank to 0.06MPa stop, progress pressure maintaining, temperature holding 37
DEG C, 0.06 MPa of pressure, speed of agitator is adjusted to 60r/min, cultivates 12 hours；
E, culture transferring: step b is carried out to 1000 liters of fermentors, the strain in 100 liters of fermentor is then passed through into the pipeline of sterilizing
It moving in the fermentor that 1000 liters prepare culture medium, temperature is kept for 37 DEG C, and 0.06 MPa of pressure, speed of agitator is adjusted to 60r/min,
It cultivates 12 hours, side viable count is sampled after growth is good in 1000 liters of fermentors；
F, be centrifuged: bacterium solution is rotated clockwise by centrifuge, centrifuge speed for 16000r/min, carries out bacterium solution separation, is completed
After take out bacterium mud；
G, it is lyophilized: bacterium mud being placed in the plate layer of freeze dryer, freeze-drying operation is carried out, -45 DEG C of temperature of freeze dryer rear lane is taken out
Vacuum；
H, bacterium powder bacterium powder: is obtained after crushing；
I, lactobacillus acidophilus bacterium powder processed, Lactobacillus casei bacterium powder and bifidobacterium lactis bacterium powder: by lactobacillus acidophilus, Lactobacillus casei
Step b to step h is repeated with bifidobacterium lactis, obtains lactobacillus acidophilus bacterium powder, Lactobacillus casei bacterium powder and bifidobacterium lactis bacterium
Powder；
J, wheatfeed processed: wheat bran is ground into powder, and crosses 200 meshes to obtain the final product；
K, yam flour processed: Chinese yam being shredded, is ground into powder, and crosses 200 meshes to obtain the final product；
L, wheatfeed is made in step j and step k and yam flour is added in raw milk, be uniformly mixed, be then preheating to 50 DEG C,
It carries out homogeneous and obtains mixed material, homogenization pressure 19Mpa；Then by the mixed material after homogeneous be placed at 90 DEG C -95 DEG C into
Row disinfection 120 seconds cools to obtained mixed liquor after 33 DEG C；
M, finished product: by clostridium butyricum bacterium powder, lactobacillus acidophilus bacterium powder, Lactobacillus casei bacterium powder, bifidobacterium lactis bacterium powder and Wei Sheng
Plain C, oligofructose, maltodextrin, lactose and inulin are matched according to the drug weight and are configured, and are added to made from step l and are mixed
It closes in liquid, is uniformly mixed post-fermentation 12 hours, terminate fermentation, cool to 10 DEG C, finished product.
Claims (2)
1. a kind of probiotic beverage with protection liver function, which is characterized in that the ingredient including following weight proportion: butyric acid
10-40 parts of clostridium bacterium powder, 10-40 parts of lactobacillus acidophilus bacterium powder, 10-40 parts of Lactobacillus casei bacterium powder, bifidobacterium lactis bacterium powder 10-
40 parts, 1-11 parts of vitamin C, 24-34 parts of oligofructose, 2-12 parts of maltodextrin, 2-12 parts of lactose, 5-15 parts of inulin, it is fresh
100-120 parts of milk, 2-5 parts of wheatfeed, 2-5 parts of yam flour.
2. a kind of preparation method of the probiotic beverage with protection liver function, which comprises the following steps:
A, strain is selected: selection clostridium butyricum strain；
B, the production of hybrid seeds: selecting sterile environment, and strain transfer needle is taken out and is put into 500 milliliters of triangular flasks equipped with culture medium,
Then it seals bottleneck to be put into incubator, 37 DEG C of the temperature of incubator, static gas wave refrigerator 12 hours；
C, it sterilizes: 100 liters of fermentors being subjected to empty elimination bacterium, culture medium is then placed in and sterilizes, 121 degrees Celsius of sterilising temp
More than, pressure inside the tank 0.12MPa, continuing 20min sterilizing terminates, and temperature in tank is then down to 37 DEG C with cooling water, tank internal pressure
Power is down to 0.01MPa；
D, it is inoculated with: the seed in incubator being put into desinfection chamber first and is sampled microscopy, is inoculated with, unscrew inoculation mouth sealing
Lid leads to filtrated air in 100 liters of tanks, guarantees that pressure inside the tank will not be zero, is placed on inoculation mouth with inoculation flame ring, lights fire
After flame circle, inoculation lid is fully opened, then triangular flask is placed on above flame ring, triangular flask is opened, seed is poured into tank,
After will inoculation lid tighten, into tank lead to filtrated air, pressure inside the tank to 0.06MPa stop, progress pressure maintaining, temperature holding 37
DEG C, 0.06 MPa of pressure, speed of agitator is adjusted to 60r/min, cultivates 12 hours；
E, culture transferring: step b is carried out to 1000 liters of fermentors, the strain in 100 liters of fermentor is then passed through into the pipeline of sterilizing
It moving in the fermentor that 1000 liters prepare culture medium, temperature is kept for 37 DEG C, and 0.06 MPa of pressure, speed of agitator is adjusted to 60r/min,
It cultivates 12 hours, side viable count is sampled after growth is good in 1000 liters of fermentors；
F, be centrifuged: bacterium solution is rotated clockwise by centrifuge, centrifuge speed for 16000r/min, carries out bacterium solution separation, is completed
After take out bacterium mud；
G, it is lyophilized: bacterium mud being placed in the plate layer of freeze dryer, freeze-drying operation is carried out, -45 DEG C of temperature of freeze dryer rear lane is taken out
Vacuum；
H, bacterium powder bacterium powder: is obtained after crushing；
I, lactobacillus acidophilus bacterium powder processed, Lactobacillus casei bacterium powder and bifidobacterium lactis bacterium powder: by lactobacillus acidophilus, Lactobacillus casei
Step b to step h is repeated with bifidobacterium lactis, obtains lactobacillus acidophilus bacterium powder, Lactobacillus casei bacterium powder and bifidobacterium lactis bacterium
Powder；
J, wheatfeed processed: wheat bran is ground into powder, and crosses 200 meshes to obtain the final product；
K, yam flour processed: Chinese yam being shredded, is ground into powder, and crosses 200 meshes to obtain the final product；
L, wheatfeed is made in step j and step k and yam flour is added in raw milk, be uniformly mixed, be then preheating to 50 DEG C,
It carries out homogeneous and obtains mixed material, homogenization pressure is 18 Mpa -20Mpa；Then by the mixed material after homogeneous be placed in 90 DEG C-
It carries out disinfection 120 seconds, is cooled to obtained mixed liquor after 33 DEG C at 95 DEG C；
M, finished product: by clostridium butyricum bacterium powder, lactobacillus acidophilus bacterium powder, Lactobacillus casei bacterium powder, bifidobacterium lactis bacterium powder and Wei Sheng
Plain C, oligofructose, maltodextrin, lactose and inulin are matched according to the drug weight and are configured, and are added to made from step l and are mixed
It closes in liquid, is uniformly mixed post-fermentation 12 hours, terminate fermentation, cool to 10 DEG C, finished product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112493488A (en) * | 2020-11-30 | 2021-03-16 | 青岛康益生物科技有限公司 | Compound probiotic preparation with effects of preventing and inhibiting tumors and preparation method thereof |
| CN113575973A (en) * | 2021-07-28 | 2021-11-02 | 武汉英纽林生物科技有限公司 | Composition for protecting liver of diabetic and preparation method thereof |
| TWI769644B (en) * | 2020-12-30 | 2022-07-01 | 陳俊宏 | Composite composition of clostridium butyricum, yeast and enzyme, oral composite including the same and application on liver protection |
-
2018
- 2018-09-25 CN CN201811112858.1A patent/CN109511736A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112493488A (en) * | 2020-11-30 | 2021-03-16 | 青岛康益生物科技有限公司 | Compound probiotic preparation with effects of preventing and inhibiting tumors and preparation method thereof |
| TWI769644B (en) * | 2020-12-30 | 2022-07-01 | 陳俊宏 | Composite composition of clostridium butyricum, yeast and enzyme, oral composite including the same and application on liver protection |
| CN113575973A (en) * | 2021-07-28 | 2021-11-02 | 武汉英纽林生物科技有限公司 | Composition for protecting liver of diabetic and preparation method thereof |
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Application publication date: 20190326 |